Antipyretic Effects of Dipyrone Versus Ibuprofen Versus

Antipyretic Effects of Dipyrone Versus Ibuprofen Versus

Antipyretic Effects of Dipyrone Versus Ibuprofen Versus Acetaminophen in Children: Re... Page 1 of 2
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Antipyretic Effects of Dipyrone Versus
Ibuprofen Versus Acetaminophen in
Children: Results of a Multinational,
Randomized, Modified Double-Blind Study
Anthony Wong, MD
Hospital de Clínicas, University of São Paulo, Brazil; Children's Institute,
Department of Medicine, University of São Paulo, Av. Dr. Eneas Carvalho de
Aguiar 647, 05403-900, São no consensus on whether fever, Paulo, Brazil
Andres Sibbald, MD
Hospital Britânico, Argentina
Fernando Ferrero, MD
Hospital de Niños “Pedro Elizalde,” Argentina
Mauricio Plager, MD
Hospital de Niños “Ricardo Gutierrez,” Argentina
Maria Elena Santolaya, MD
Hospital Luis Calvo Mackenna, Chile
Anna Maria Escobar, MD
Hospital de Clínicas, University of São Paulo, Brazil
Sandra Campos, MD
Hospital São Paulo, Brazil
Sergio Barragán, MD
Hospital Regional “Lic. Adolfo Lápez Mateos,” Mexico
Maximiliano De León González, MD
Hospital Juarez de Mexico, Mexico
http://cpj.sagepub.com/content/40/6/313.abstract
6/15/2011
Antipyretic Effects of Dipyrone Versus Ibuprofen Versus Acetaminophen in Children: Re... Page 2 of 2
Gustavo Lf Kesselring, MD
Aventis Pharma, Brazil
Fever Pediatric Study Group
Abstract
This study compared the antipyretic effectiveness of acetaminophen, ibuprofen, and
dipyrone in young children with fever. The results were based on a modified doubleblind, randomized, multinational trial that evaluated 628 febrile children, aged 6 months
to 6 year. All three drugs lowered temperature in the 555 patients completing the study.
Temperature normalization rates in the ibuprofen and dipyrone groups (78% and 82%,
respectively) were significantly higher than the acetaminophen group (68%, P=0.004).
After 4 to 6 hours, mean temperature in the dipyrone group was significantly lower than
the other groups, demonstrating longer temperature normalization with dipyrone. All
three drugs showed comparable tolerability profiles.
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http://cpj.sagepub.com/content/40/6/313.abstract
6/15/2011