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Apresentação do PowerPoint - Springer Static Content Server
PEGylation of SPIONs by polycondensation reactions: A new strategy to improve colloidal stability in biological media Journal of Nanoparticle Research Wesley Renato Viali1, Eloiza da Silva Nunes1, Caio Carvalho dos Santos1, Sebastião William da Silva2 , Fermin Herrera Aragón2; José Antonio Huamaní Coaquira2, Paulo César Morais2,3, Miguel Jafelicci Júnior1* 1 Laboratório de Materiais Magnéticos e Coloides, Departamento de Físico-química, Instituto de Química, Universidade Estadual Paulista, Araraquara, SP, 14801-970, Brazil 2 Instituto de Física, Núcleo de Física Aplicada, Universidade de Brasília, Brasília, DF, 70910-900, Brazil 3 Department of Control Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China. *Corresponding Author: [email protected] ; Fone: +55 16 3301-9651 Raman Intensity (u.a) 200 670 713 315 385 400 506 600 -1 Wavenumber (cm ) 800 Fig. S1 Raman Spectra of Mag-1000 using a 632.8 nm laser Fig. S2 HR-TEM micrograph of Mag-PEG1000 sample 160 Number of Particles a b 120 80 40 0 20 nm 2 4 6 8 10 Particle diameter (nm) 12 100 Number of Particles c 20 nm 80 d 60 40 20 0 2 4 6 8 Particle diameter (nm) Fig. S3 a TEM micrograph of Mag-cit sample; b particle size histogram of Mag-cit sample; c TEM micrograph of Mag-PEG200 sample; d particle size histogram Mag-PEG200 sample 10 Fig. S4 a 13C NMR spectra and; b DRIFTS of PEG-citrate co-polymer synthesized in the absence of SPIONs. PEG Mw 1000 Fig. S5 Dependence of the stability factor, W, on the NaCl concentration at pH = 7 for Mag-citrate (–●–) and Mag-PEG200 (–■–) Fig S6 Hydrodynamic diameter as a function of time at MgCl2 concentrations ranging from 0.01 to 1.0 mol L-1 (pH = 7.0): a Mag-PEG400; b Mag-PEG600; c Mag-PEG1000; d Mag-PEG3350 Fig S7 Data relating to Mag-PEG 1000 synthesized in the absence of citric acid (control). a Hydrodynamic diameter versus pH at 0.002 mol L-1 NaCl; b Hydrodynamic diameter versus time at pH = 7.0 a b Fig S8 Surface-modified SPIONs, Mag-cit and Mag-PEG (polymer Mw 200, 400, 600, 1000 and 3350), dispersed in DMEM containing 10% of foetal bovine serum. a right after preparation; b after 20 days
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