Programação do XVI Congresso da SBBC e 10th International

Transcrição

July 25th- 28th, 2012
Rio de Janeiro, Brazil
1
Contents
www.sbbc.org.br
Scientific Content
Welcome to ICCB 2012
SBBC Council and Committees
ICCB 10th Annual Meeting Supporters
Meeting at a Glance
Pre-Meeting Educational Activities
Wednesday Program
Thursday Program
Friday Program
Saturday Program
Travel Awards
General Information
Meeting Registration
Meeting Policies
Meeting resources
Transportation and Hotel Map
General Travel Information
Important phone numbers
RioCentro Convention Center Attendee Resources
RioCentro Convention Center Floor Plans
Exhibitors
Exhibitor Listings
Exhibit Hall Floor Plan
Poster Information
Poster sessions and assignment
Presentation instructions
Poster title list
Authors
Author Index
2
Welcome!
Welcome to the heart of biomedical sciences! As important as the function of cells
for life, cell biology is at the center stage of science nowadays, either through the
promises in therapy strategies and biotechnology or through the development of new
tools and concepts, not to forget its importance and influence on science education.
The program is dense, explores the many aspects of this fascinating area, and
counts on the contribution from internationally recognized experts. We would like to
express our sincere gratitude to invited speakers, guests, participants, exhibitors and the
staff working to the different committees. This is also a great opportunity to thank the
Brazilian Society for Cell Biology (SBBC) and the International Federation of Cell Biology
(IFCB) for the partnership, and the different government agencies and institutions that
contributed for both organizational and financial aspects, especially FIOCRUZ.
The ICCB2012 is a happy and timely coincidence between the International
Congress on Cell Biology and the Congress of the Brazilian Society for Cell Biology, which
was detected and worked out in 2004. By that time, SBBC hosted the Ibero-American
Congress of Cell Biology (CIABIC) in Campinas, and it became clear that integration of
Latin America should be strongly encouraged for the following years. In practical terms,
ICCB2012 will gather more than 2000 participants, which is twice as large as SBBC biennial
meetings.
ICCB2012 is one of the sixty nine international events taking place in Rio in 2012,
and the city will host the World Soccer Cup in 2014 and Olympic Games in 2016. All this
only reinforces the vibrating environment that we will be in for the next four days.
We hope that by putting this meeting together we will be able to contribute to the
discussion and definition of Cell Biology for the next years and moreover, we intend to
create a forum to highlight the importance of science development in a nation whose
origin roots up the hills in the Wonderful City and increases the pathways and
connections for its integration regionally. Have a great ICCB and enjoy your stay in Rio!
Hernandes F Carvalho and Patricia Gama
Co-Chairs ICCB 2012
3
th
th
10 ICCB and 16 SBBC Meetings
Co-Organizers
The Brazilian Society for Cell Biology (SBBC)
EXECUTIVE COMMITTEE
President
Vice-President
Directors
Secretary
Treasurer
Wilson Savino - Fiocruz, Rio de Janeiro
Vilma R Martins – Hospital A C Camargo, São Paulo
Marimélia Porcionatto - UNIFESP, São Paulo
Patrícia Gama - USP, São Paulo
Flavia A C Gomes - UFRJ, Rio de Janeiro
Irene Yan - USP, São Paulo
Marinilce F Santos - USP, São Paulo
The International Federation for Cell Biology (IFCB)
President
Denys Wheatley - Aberdeen, Scotland, UK
Vice-President
Cheng-Wen Wu - NHRI, Taiwan
Secretary General Hernandes F Carvalho - UNICAMP, Brazil
Executive organization
Av. das Américas 3500 – Bl. Hong Kong 3000 - Sl. 405
Le Monde Office - Barra da Tijuca - RJ - 22640-102
Tel.: 55 21 3326-3320 Fax: 55 21 2437-1483
www.interevent.com.br
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Organizing Committee
Co-Chairs
Hernandes F Carvalho (State University of Campinas)
International Federation for Cell Biology IFCB
Patrícia Gama (University of São Paulo)
Brazilian Society for Cell Biology SBBC
Brazilian Committee
Estela Bevilacqua (University of São Paulo)
Flávia Gomes (Federal University of Rio de Janeiro)
Irene Yan (University of São Paulo)
Marinilce F Santos (University of São Paulo)
Marimélia Porcionatto (Federal University of São Paulo)
Milton Moraes (FIOCRUZ)
Thereza Christina Barja-Fidalgo (University of Rio de Janeiro)
International Contacts
Europe: Anne Eichmann (College de France, France; Yale University, USA)
US: Bechara Kachar (NIDCD, NIH, USA)
Latin America: Gabriel Rabinovitch (Buenos Aires University, Argentina)
Asia: Ken Wen Wu (NHRI, Taiwan)
Australia: James Armitage (Monash University, Australia)
Scientific Committee
Bechara Kachar
Betina Malnic
Carla Collares
Carlos Ramos
Célia Regina Garcia
Celuta Sales Alviano
Cláudia Mermelstein
Claudio Simon
Constance Oliver
Edna Kimura
Emer Suavinho Ferro
Enilza Espreafico
Estela Bevilacqua
Fábio Papes
Fernando Costa e Silva Filho
Flávia CA Gomes
Glaucia Santelli
Gustavo Amarante Mendes
Hernandes F Carvalho
Hugo Armelin
Irene Yan
Ivarne Tersariol
Jorg Kobarg
José Garcia Abreu
José Mauro Granjeiro
José Xavier Neto
Klaus Hartfelder
Luiz Renato França
Manoel Costa
Mari Sogayar
Maria Célia Jamur
Maria Isabel Cano
Marimélia Porcionatto
Marinilce F Santos
Marlene Benchimol
Mirian Jasulionis
Nadja Souza-Pinto
Paolo Meda
Patrícia Bozza
Patrícia Gama
Renata Pasqualini
Ricardo Guellerman
Roger Chammas
Ruy Jaeger
Sang Won Han
Sérgio Schenckman
Silvana Allodi
Vilma R Martins
Vivaldo Moura Neto
Wadih Arap
Wanderley de Souza
Wilma Kempinas
Wilson Savino
5
The organizers gratefully acknowledge the
Financial Support
FCW
Fundação
Conrado
Wessel
Institutional Support
6
The organizers gratefully acknowledge Exhibitors and Sponsors
Fairport
Biolince
INFABIC- INCT
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Program at a Glance
July 25th (Wednesday)
Room #
201
Cell Migration
Marcelo Lamers
09h00- 10h30
202
204
205
Image J
Cell culture as
Transcriptional
A public domain alternative model
regulation &
for image
for animal
transcriptome
processing and experimentation
analyses
analysis
Silvya S MariaKlaus Hartfelder
Ruy Jaeger
Engler &
Silvia Berlanga
10h30- 10h45
12h00
12h15
Plant Cell
Biology
Adriana S
Hemerly
207
208
209
212
Neurobiology
signaling and
plasticity in glial
cells
Flávia Gomes
Advanced
Microscopy
Manoel Costa
Muscle cell
differentiation
Claudia
Mermelstein &
Cécile GauthierRouviere
(SBBC & French
Society for Cell
Biology)
Cellular and
molecular
tools for
invertebrate
models
Silvana
Allodi
Neurobiology
signaling in glial
cells
Advanced
Microscopy
Muscle cell
differentiation
Cellular and
molecular
tools for
invertebrate
models
Cooffe Break
Cell Migration
10h45- 12h15
Courses
206
Image J analysis
Cell culture as
alternative model
for animal
experimentation
Transcriptional
regulation &
transcriptome
analyses
Plant Cell
Biology
Exhibits open
Lunch
8
12h30
Room #
12h30- 14h00
14h00-15h00
201
202
204
Special Interest Activities
205
206
Round Table:
Publishing in Cell
Biology
Roger Chammas
12h45-14h45
SBBC Workshop:
Can universities
help schools?
Marimélia
Porcionatto
L #1
L #2
Claudio Joazeiro
Daria M-Rosen
Neurodegeneration Metabolic stress
L #3
Mark Ellisman
Frontiers in
Microscopy
Imaging
L #4
Y Shav-Tal
Single gene
tracking
17h30
17h30
12h45-14h45
Can universities
help schools?
L #5
Célia R Garcia
Host Parasite
Interaction:
Malaria
208
209
12h45-14h45
IFCB Workshop:
Scientific Writing
Denys Wheatley
12h45-17h00
Workshop:
Creative Cell
Biology in
schools
Luiz Anastacio
Alves
12h45-14h45
IFCB Workshop:
Scientific Writing
12h45-17h00
Workshop:
Creative Cell
Biology in
schools
Coffee Break
15h00
15h30-17h00
207
Symp #1
Prions
Jerson Lima e Silva
Symp #2
Symp #3
Symp #4
Programs,
Gene Therapy
Cell Biology and
Genes, and
Martin Bonamino
Reproduction
Homeostasis
Luiz Renato
José Xavier Neto
França
Symp #5
Host Parasite
Interaction
Wanderley de
Souza
12h45-17h00
Workshop:
Creative Cell
Biology in
schools
Exhibits close
Opening Ceremony (Main Hall)
Keynote Conference
Elaine Fuchs
9
July 26th (Thursday)
Room #
201
202
204
205
207
208
Symp #6
Membrane biology
José Garcia Abreu
Symp #7
Signaling in
Development
Ricardo G P Ramos
Symp #8
Epithelial
Proliferation &
Differentiation
Mari Sogayar
Symp #9
Immune Cell
Biology
Wilson Savino
Symp #10
Cell Biology and
Education
Bruce Alberts &
Cynthia Jensen
(American Society
for Cell Biology &
IFCB)
Symp #11
Glia Club
Vivaldo Moura
Neto & Bernardo
Castellano
08h45 - 10h15
10h00
Exhibits open
Break
Keynote Conference (Main Hall)
Douglas Green
10h15
10h45- 11h45
11h45-13h45
Room #
12h15-13h45
13h00-14h00
Room #
14h00-15h00
Pavillion 5 (1st and 2nd floors) / 1st Poster Session
Poster Presentation 11h45-12h45 even nrs
Poster presentation 12h45-13h45 odd nrs
201
202
Special Symp
Selected abstracts
(Professionals)
Special Symp
Selected abstracts
(Graduate students)
Exhibitors - technical conferences
205
GE Healthcare
Bruce Alberts
Room # 204
IFCB General Assembly
207
Nikon
208
Life Technologies
10
Room #
15h15-16h15
201
202
204
205
207
L #6
Juan Bonifacino
Polarized Sorting in
neurons
L #7
Anne Eichman
Guidance of
vascular patterning
L #8
Hans Clevers
Intestinal stem cell
L #9
Mauro Pavão
Targeting proteinglycan interactions
L #10
Alejandro Schinder
Neurobiology
Coffee Break
16h15-16h45
16h45-18h15
208
Symp #12
Protein Folding and
Assembly
Carlos Ramos
Symp #13
Vascular Cell
Biology
Robson Monteiro
Symp #14
Cell Cycle control
mechanisms
Hugo Armelin &
Patrícia Gama
Symp #15
Migration and
Regeneration
Fernando Costa e
Silva Filho
Symp #16
Inflammation
Patricia Bozza
Symp #17
Glia
Flávia Gomes
207
208
Exhibits close
Ruslan Medzhitov
18h00
18h30-19h30
July 27th (Friday)
Room #
201
Symp #18
Cancer therapy
Jorg Kobarg
08h45 - 10h15
10h00
10h15
10h45- 11h45
11h45-13h45
202
204
Symp #19
Symp #20
Regulators of
Tissue Regeneration
neural transmission
Juan Larrain
Vilma Martins &
Roy Larson
205
Symp #21
Metabolic
Programming
James Armitage
Symp # 22
Symp #23
Mitochondria
Cytotoxicity
Nadja Souza-Pinto Sandra Azevedo &
& Enilza Espreafico Tamara Lah Turnsec
Exhibits open
Break
Daniel St Johnston
Pavillion 5 (1st and 2nd floors) / 2nd Poster session
Poster Presentation 11h45-12h45 even nrs
Poster presentation 12h45-13h45 odd nrs
Room # 204
SBBC General Assembly
11
Room #
12h15-13h45
201
202
Special Symp
Selected abstracts
(Undergraduate
students)
Special Symp
Selected abstracts
(Graduate students)
Exhibitors - technical conferences
205
Carl Zeiss
13h00-14h00
Room #
Room #
14h15-15h15
201
202
204
L #11
Miriam Jasiulionis
Epigenetics and
malignant
transformation
L #12
Stefan Linder
Podosomes,
microtubules and
motor proteins
L #13
Marcelo Morales
Bone-marrow stem
cell therapy
Symp #24
Cancer
Renata Pasqualini
17h30-18h30
18h00
208
Roche
205
207
208
Symp #27
Maternal interface
Estela Bevilacqua
Symp #28
Cells as biosensors
Glaucia Santelli &
Paulo Saldiva
Special Symp
Oral Presentations
(Extra Session)
Coffee Break
15h15-15h45
15h45-17h15
207
BD
Symp #25
Cell motility
James Sellers
Symp # 26
RNA regulation
Jean Pierre Perrault
(Canadian Cell
Biology Society) &
Carla C Oliveira
Jennifer Lippincott-Schwartz
Exhibits close
12
July 28th (Saturday)
9h00
Room #
9h00-10h00
Exhibits open
201
202
204
205
L# 14
Rick Horwitz
Mechanosensing
through myosin II
L# 15
Stephen Doxsey
Mitotic
centrosomes in
asymmetric events
L# 16
Andrzej Bartke
Growth hormone
and Aging
L #17
Sérgio Ferreira
Neurodegenerative
disorders
Coffee Break
10h00
10h30-12h00
Symp # 29
MMPs and TIMPs
Ruy Jaeger
Symp #30
Telomeres
Maria Isabel Cano
Symp #31
Cancer Stemness
Ken Wu
(Taiwan Society for
Cell and Molecular
Biology)
12h00
Exhibits close
Lunch
12h00
Room #
13h00
14h15- 15h15
15h15-15h45
Symp #32
Unconventional
organelles
Marlene Benchimol
201
202
204
L #18
Peter Friedl
Cell migration
L# 19
Xavier Belles
MicroRNAs and
metamorphosis
L #20
Rafael Linden
Prions
Closing conference (Main Hall)
Richard Hynes
Closing remarks (Main Hall)
13
GENERAL INFORMATION
ATTENDEE AND EXHIBITOR REGISTRATION
Wednesday, July 25th
7h30-17h30
Thursday, July 26th
8h00-18h00
Friday July 27th
8h00-17h00
Saturday July 28th
8h00-16h00
SBBC MEETING MANAGEMENT/BUSINESS OFFICE
Registration counter and Exhibition Hall
14h00- 17h00
MEDIA DESK & VIP ROOM- 2nd floor Room 210
8h00- 17h00
BADGES/REPLACEMENT POLICY
Meeting badges must be worn at all times while in RioCentro Convention Center. Children
over the age of 12 must wear a badge. There is a R$ 30,00 charge for lost or misplaced
badges. Photo identification will be required for replacement. To avoid these charges,
please remember to bring your meeting badge and materials with you.
CAMERAS
Cameras and other recording devices are prohibited in Poster Sessions.
DRINKING AND SMOKING POLICIES
The SBBC and IFCB encourage responsible drinking for those drinking alcohol. Coffee and
water will be offered at Coffee breaks. Alcoholic beverages are allowed only in specific
areas. According to Rio de Janeiro State Law 5.517 it is prohibited to smoke in any area at
any public area, including the Convention Center.
Food Court
A Food Court will be available during meeting hours and will be organized with different
restaurants.
EXHIBIT HALL HOURS
Wednesday
Thursday and Friday
Saturday
12h00- 17h30
10h00-18h00
9h00- 13h00
14
GROUND TRANSPORTATION
In Rio de Janeiro, public transportation includes buses, subway and trains. Ticket costs
around R$ 3,00. An integrated special ticket (bilhete único) can be used both in buses and
subway. A special bus service runs from the Airports (Galeão and Santos Dumont) to
specific sites in the city. For more information: www.rioonibus.com
https://www.cartaoriocard.com.br/scrcpr/ For bus routes check:
http://www.vadeonibus.com.br/vadeonibus/index.php
Taxis are yellow in Rio de Janeiro, and there are two other companies working as red and
blue.
There will be a bus service to and from Riocentro, see the map below.
LOST AND FOUND AND MESSAGE CENTER
Please contact Registration Desk for lost and found. Messages for invited speakers and/or
attendees should be left at ICCB registration desk.
POSTER SESSIONS
Poster Sessions will be held at 1st and 2nd floors (Room 203) and will be organized according
to the different areas (informed below).
Poster Session I: Thursday, July 26th
Poster Session II: Friday, July 27th
Author presentation for both sessions:
11h45- 12h45 even numbers
12h45-13h45- odd numbers
Poster numbers will identify the boards. Tapes and hangers should be brought to the area
by presenters. The Organizing Committee will not provide these items and will not collect
and keep Posters that are left on the Boards.
SAFETY AND SECURITY
Rio de Janeiro is a large city and care should be taken as in any other huge city. We are
committed to make the necessary efforts to ensure a safe, productive and nice event for
everyone. Please remember to take off your badge when exiting the Convention Center.
Please be aware of your surroundings at all times. For emergencies while in RioCentro,
contact a uniformed security officer. For emergencies while in your hotel, please follow the
specific instructions.
WEATHER
July monthly highs average 25o C, lows average 15o C. It is usually a dry season in Rio de
Janeiro.
15
Transportation and hotels
Two differents Routes will be serving the Congress.
Transportation System
Routes
Blue Route: from Barra da Tijuca Beach
Stops
Praia Linda, Windsor Barra, Sheraton Barra
and Casa del Mar
Red Route: From Avenida das
Américas
Barra First and Bourbon Residence
Guests staying at the hotels: Paradiso All Suites, Transamérica Barra and Royalty Barra must take
the Blue Route transportation.
Departures to Rio Centro (Blue Route and Red Route)
July 25th
Beetween 07:15 | 07:30
Between 12:00 | 12:15
July 26th
Between 07:30 | 07:45
Between 09:00 | 09:15
July 27th
Between 07:30 | 07:45
Between 09:00 | 09:15
July 28th
Between 08:00 | 08:15
Between 09:30 | 09:45
Between 16:30 | 16:45
Return from Rio Centro (Blue Route and Red Route)
July 25th and July 26th
19:45
July 27th
18:45
July 28th
15:45 (*)
(*) On this day, there will be transportation departuring from Rio Centro to the Internacional
Airport (Galeão) and Santos Dumont Airport, in this order.
A free bus will be running from Barra Shopping (BS) to Riocentro (RC) and back at hourly
schedule (starting at 12h30 at BS on July 25th and 8h00 (BS) on the
following days). For more information contact the registration desk.
16
More on travelling information
BARRA DA TIJUCA
Barra da Tijuca is Rio´s most modern living complex and community; sophisticated, vibrant and
offering innumerable attractions such as fine bars and restaurants serving world class cuisine, airconditioned shopping malls featuring world famous fashions and designers labels, theme parks,
ecological reserves and sports of all types. Only 15 km from Ipanema Beach and 18 km from
Copacabana this part of the city is on continued expansion and is becoming Rio’s business and
economic center extended by miles of an outrageous virgin beach. While in Rio don’t miss the
opportunity to discover the city.
PASSPORT & VISAS
Passports are required for all foreigners. Brazil’s visa requirements are based upon reciprocity. If
your home country requires a visa for Brazilian travelers, you will need one for your visit. Additional
information can be obtained from the nearest Brazilian Embassy or Consulate. Your passport
expiration date should be at least six months from the date of your arrival. For more information,
please visit http://www.passportsandvisas.com/visas/brazil-visa-faq.asp
HEALTH
There are no compulsory health requirements for entry into Brazil. We suggest that you contact
your local Consulate for current advice. Please note that if you are entering Brazil via Colombia,
Equador or Peru, you will be required to provide a current yellow fever vaccination certificate for
immigration purposes.
MEDICAL AND INSURANCE SERVICES
Rio de Janeiro and Brazil have a number of internationally respected hospitals, clinics and doctors,
but treatment is costly, so visitors are strongly advised to take out medical trip insurance.
The Congress Organization is not liable for any health problems, personal accidents, lost baggage or
cancellation of travel arrangements, flights, etc. We recommend that participants provide their
own insurance policies.
FOOD & DRINKS
The most common dishes feature various meats, rice and the ubiquitous Brazilian black beans
(feijão), while restaurants many times offer all-you-can-eat barbecues and buffets.
Many kinds of alcoholic drinks are available, including excellent lager style beers such as Antarctica,
Brahma, Cerpa and Skol. The most popular local beverage is Cachaça, most commonly served as
'Caipirinha' with slices of lime or lemon. There are no restrictions on licensing hours. Soft drinks
include Guarana (a carbonated cola-like drink, made from the Amazon fruit, guarana) and many
varieties of fruit juices (sucos). Brazilian coffee tends to be served less strong than Italian coffee, so
if stronger coffee is desired, request express coffee (café expresso). If you would like to avoid sugar
in juices or coffee, you should specifically request that it not be added.
FOREIGN EXCHANGE
The Brazilian monetary unit is the Real (R$). Exchange rates are published daily in the newspaper.
Cash and traveler checks, especially US Dollars (USD), can be exchanged at most banks, exchange
houses and major hotels.
• Bank notes (paper money) are in denominations of R$ 100, R$ 50, R$ 10, R$ 5, R$ 1.
• Coins are 1.00 real, 50 centavos (cents), 25 centavos, 10 centavos and 5 centavos.
• Banking Hours - 10:00-16:00 Monday to Friday.
17
TIPPING
In most restaurants and bars, a 10% service fee is added to the bill. More sophisticated places may
add 15%. If service is not included, it will be stated at the bottom of the bill: “Serviço não incluído.”
Airport and hotel porters: the R$ is equivalent to the USD of $1.00 per suitcase. Hotels: Hotels
generally include any service charge on the bill. Restaurants: Tips are discretionary, but often found
on the final bills as a "suggestion." In Brazil, a typical tip remains 10%. Taxis: Tips are not expected
by taxi drivers although most passengers will round the fare up if satisfied with the service
SOME LAST ADVICES TO ENJOY RIO
Below, are a few general recommendations to help you enjoy a safe and relaxing trip to Rio de
Janeiro:
Never leave your luggage unattended or with a stranger and please be aware that some may
attempt to create a distraction to divert your attention from your belongings.
The sun in Brazil can be more direct and stronger - extra precautions are necessary
Be aware of dangerous undertows; stay near other bathers and observe the warning flags. Do not
go to the beach at night. Avoid wearing expensive jewellery or watches, carry limited amounts of
cash and keep your passport and other important travel documents at your hotel. When not in use,
it is advised that you carry your camera in your pocket and as a precaution, be sure to carry your
bag in front of you.
IMPORTANT PHONE NUMBERS
Brazil code:
55
Rio de Janeiro code
21
Police
190
Emergency and Fireman
193
Internacional Airport
0800999099
Domestic Airport (Santos Dumont)
0800244646
Riocentro
3035 9100
18
Meeting will be held at RioCentro Convention Center
Av Salvador Allende 6555, Barra da Tijuca, Rio de Janeiro, RJ, 22780-160 Brazil
Google maps
At Riocentro ICCB is at Pavillion 5
You are here
Pavillion 5
19
Pavillion 5 1st floor
Exhibitors
Ambriex
AOTEC
BD Biosciences
Biogen
Biolince
Biometrix
Carl Zeiss
Fairport
FUNPECPeprotec
GE Healthcare
INFABIC- INCT
Inopat
John Wiley
Life
Technologies
Lonza
Merck Millipore
Nikon
Nobilis Tur
Nova Analítica
Olympus
Perkin Elmer
Promega
Roche
SBBC
SBS Livraria
Sigma
Spectrun
Pavillion 5 2nd Floor
20
Pre-meeting activities
SBBC Educational program
Workshop “Experiencing Biology”
June 23rd, 2012
Escola Estadual Leda Guimarães Natal (Parelheiros, São Paulo, SP)
Coordination: Profa Dra Marimélia Porcionatto (UNIFESP)
Advanced Optical Microscopy Course
July 16th- 20th
Universidade Federal do Rio de Janeiro, UFRJ
Coordination: Prof Dr Manoel Luis Costa
Wednesday, July 25
 Courses
9h00- 12h15 (Coffee Break 10h30- 10h45)
Room 201
Cell Migration
Marcelo Lamers, Peter Friedl, Alan Horwitz
Room 202
Image J: A public domain for image processing and analysis
Ruy Jaeger
Room 204
Cell culture as alternative model for animal experimentation
Silvya Stuchi Maria-Engler, Silvia Berlanga
Room 205
Transcriptional regulation & transcriptome analyses
Klaus Hartfelder
Room 206
Plant Cell Biology
Adriana Silva Hemerly, Marcelo Dornelas
Room 207
Neurobiology signaling and plasticity in glial cells
Flávia Gomes, Arturo Ortega, Ricardo A Melo Reis, Adan Aguirre, Marcelo Santiago
Room 208
Advanced Microscopy
Manoel Costa, Clarissa Henry, John Murray, João Menezes
Room 209
Muscle cell differentiation
Cláudia Mermelstein, Cécile Gauthier-Rouviere (SBBC & SFBC)
Room 212
Cellular and molecular tools for invertebrate models
Silvana Allodi, Cintia M Barros, Dib Ammar, Rodrigo Fonseca, Juliana Américo
12h00 – Exhibits open
21
 Round Table and Workshops
12h30- 14h00
Room 201
Special Interest Subgroup
Round Table: Publishing in Cell Biology
Chair Roger Chammas
Bruce Alberts, Fiona Watt
12h45- 14h45
Room 206
SBBC Workshop: Can universities help schools?
Marimélia Porcionatto
Room 208
IFCB Workshop: Scientific Writing
Denys Wheatley
12h45- 17h00
Room 209
Workshop: Creative Cell Biology in schools
Luiz Anastácio Alves, Flávia Lima, Daniela Uziel Rozental
 Lectures
14h00- 15h00
Room 201
L# 1
Claudio Joazeiro
The Scripps Research Institute, La Jolla, USA
The ribosome-associated E3 ubiquitin ligase, Listerin (Ltn1), is
implicated in neurodegeneration and mediates a novel pathway of
protein quality control
Chair: Marilene H Lopes
Room 202
L# 2
Daria Mochly-Rosen
Stanford University, USA
Excessive mitochondrial fission mediated by PKC and by Drp1
activation; new targets for neuroprotection
Chair: Déborah Schechman
Room 204
L# 3
Mark Ellisman
University of California San Diego, USA
New approaches for correlated LM and 3D EM applied to
MULTISCALE CHALLENGES: Bridging Gaps in Knowledge and
Understanding
Chair: Marcia Attias
22
Room 205
L# 4
Yaron Shav-Tal
Bar-Ilan University, Ramat Gan, Israel
Dynamics of gene expression in real-time measured on single
genes in single living cells
Chair: Jean Pierre-Perreault
Room 207
L#5
Célia Regina Garcia
Universidade de São Paulo, Brasil
PfCBF transcription factor, a new player for signal
transduction in melatonin-pathways in malaria parasites
Chair: Sérgio Schenkman
15h00- Coffee Break
 Symposia and Special Interest Subgroups
15h30- 17h00
Room 201
Symp #1 Special Subgroup
Prion protein in physiology and pathology
Chair: Jerson Silva
Vilma Martins
Hospital A.C. Camargo, São Paulo, Brasil
Neurodegeneration and cancer: a crosstalk between prion protein and its ligand
STI1
David Harris
Boston University School of Medicine, Boston, USA
Neurotoxic Activities of PrPC in Prion and Alzheimer’s Diseases
Jerson Silva
Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
Room 202
Programs, Genes and Homeostasis
Chair: José Xavier Neto
Michael Schubert
Université de Lyon, France
Retinoic acid signaling in development and evolution
Kleber Franchini
LNLS, Campinas, Brazil
José Xavier Neto
LNLS, Campinas, Brasil
Ancient programs of gene expression in development and homeostasis
23
Room 204
Gene Therapy
Chair: Martin Bonamino
Luigi Naldini
Director, San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Italy
A Hematopoietic Stem Cell (HSC) Specific microRNA Gives Novel Insights into the
Regulation of HSC Homeostasis and Allows Safer HSC-based Gene Therapy
Rafael Linden
Universidade Federal do Rio de Janeiro, Brazil
Fundamentals of a novel approach to gene therapy of glaucoma
Martin Bonamino
Instituto Nacional de Cancer, Rio de Janeiro, Brazil
Conditional models for Chimeric Antigen Receptor (CAR) based activation of T
lymphocytes
Room 205
Cell Biology & Reproduction
Chair: Luiz Renato França
Richard Sharpe
University of Edinburgh, UK
Fetal testis differentiation and function, its regulation and its disorders
Maria Christina Werneck Avellar
Universidade Federal de São Paulo, Brazil
Antimicrobial Proteins Secreted by the Epididymis
Luiz Renato França
UFMG, Belo Horizonte, Brazil
Spermatogonial stem cell niche in vertebrates
Room 207
Host Parasite Interaction
Chair: Wanderley de Souza
Wanderley de Souza
Universidade Federal do Rio de Janeiro (UFRJ), Brazil
Introductory notes
Sérgio Schenkman
Universidade Federal de São Paulo (UNIFESP), Brazil
Dephosphorylation of eIF5A is Required for Translation Arrest at the Stationary
Growth Phase of Trypanosoma cruzi
Kiaran Kirk
The Australian National University, Canberra, Australia
Ion Regulation in the Malaria Parasite: The Target of a New Generation of
Antimalarials
Michel Rabinovitch
Universidade Federal de São Paulo (UNIFESP), Brazil
Why coinfect cells with non-viral pathogens?
24
 Keynote Conference
17h30 Opening Cerimony
Main Hall
Opening Conference
Elaine Fuchs
The Rockefeller University, New York, USA
Skin Stem Cells in Homeostasis, Wound Repair and Cancer
Chair: Estela Bevilacqua
Thursday, July 26
 Symposia
8h45- 10h15
Room 201
Symp #6
Membrane Biology
Chair: José Garcia Abreu
Christophe Lamaze
Institut Curie, Paris, France
Membrane Dynamics and Mechanics of Signaling: Role of Caveolae
Derek Toomre
Yale University School of Medicine, USA
Studying spatial control of exocytosis at the nanoscale in living cells
José Garcia Abreu
Universidade Federal do Rio Janeiro, Brazil
New inhibitory Wnt/β-catenin mechanisms affecting embryonic head formation
Room 202
Symp #7
Signaling in Development
Chair: Ricardo Guellerman Pinheiro Ramos
Roeland Nusse
Wnt Signaling, Stem Cells and Tissue Repair
Olivier Pourquié
Institut de genétique et biologie moleculaire et celulaire, INSERM, France
Formation of the Vertebrate Body Axis
Matthew Scott
Hedgehog Signaling in Development and Disease
Room 204
Symp #8
Epithelial proliferation and differentiation
Chair: Mari Sogayar
Fiona Watt
CRUK Cambridge Research Institute, Li Ka Shing Centre, UK
Intrinsic And Extrinsic Regulation Of Epidermal Stem Cell Fate
25
João Viola
Program of Cellular Biology, Instituto Nacional de Câncer (INCA), Rio de Janeiro, RJ,
Brazil.
Differential roles for NFAT transcription factor isoforms in cell transformation
Mari Sogayar
Department of Biochemistry, Chemistry Institute, University of São Paulo, São
Paulo, Brazil
Room 205
Symp #9
Immune Cell Biology
Chair: Wilson Savino
Flávio Salazar Onfraya
University of Chile
Immunological and Clinical Outcomes of a New DC-Based Vaccine
Augustin G Zapata
Faculty of Biology, Complutense University, Spain
Eph/ephrin-mediated interactions govern functional maturation of developing
thymocytes in the thymic epitelial 3D network
Wilson Savino
Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil
Room 207
Symp #10
Cell Biology and Education (ASCB & IFCB Symposium)
Chairs: Bruce Alberts and Cynthia Jensen
Cynthia Jensen
University of Auckland, New Zealand
Cell Biology and Education
Marlene Behchimol
Universidade Santa Úrsula and Fundação CECIERJ, Rio de Janeiro, Brasil
Teaching at Distance: Interactive Multimedia of the Cell Biology of
Trypanosoma cruzi
Kiaran Kirk
The Australian National University, Canberra, Australia
Engaging undergraduate students in research
Room 208
Symp #11
Glia Club
Chairs: Vivaldo Moura Neto and Bernardo Castellano
Arthur Butt
University of Portsmouth, U.K.
GSK3β is a profound negative regulator of oligodendrocyte differentiation and
myelination
Geoff Pilkington
University of Portsmouth, UK
Role of cancer stem cells in adult and paediatric brain neoplasms: hoax or holy
grail?
Tamara Lah Turnsec
National Institute of Biology, Ljubljana, Slovenia
Mesenchymal Stem Cells lower proliferation and invasion of Glioblastoma cells,
exploiting the Immune Response Mediating Chemokines
26
Bernardo Castellano
Universidade Autonoma de Barcelona
Effects of CNS-targeted Il-6 or Il-10 production on microglial activation and
motor neuron degeneration after facial nerve axotomy
10h00 – Exhibits open
10h15- 10h45 – Break
10h45- 11h45
Main Hall
Douglas Green
St. Jude Children's Research Hospital, USA
Cell death
Chair: Wilson Savino
st
 1 Poster Session
11h45- 12h45
Pavillion 5 (1st and 2nd floors) Poster Presentation - even numbers
12h45- 13h45
Pavillion 5 (1st and 2nd floors) Poster Presentation - odd numbers
11h45 – IFCB General Assembly – Room 204
 Symposia- Selected Abstracts
12h15- 13h45
Room 201
Special Symposium Professional selected abstracts
Hiroshi Hosoya,Hiroshima University
Hinrich P Hansen University Clinic Cologne, Köln, Germany
Simone Vargas da Silva, Universidade do Estado do Rio de Janeiro
Danielle Pereira Cavalcanti, Inmetro
Patricia V. Burgos, Universidad Austral de Chile
Chairs: Maria Inês Borella, Flávia Lima and Graciela Dutari
27
Room 202
Special Symposium Graduate students selected abstracts- Session I
Andrew Oliveira Silva, Universidade Federal do Rio Grande do Sul
Gabriela Nana Colaneri, Universidade Federal de São Paulo, UNIFESP
Priscila Teles de Tolêdo Bernardes, UFMG
Luciana Pescatore, FM USP
Diego Pinheiro Aguiar, ICB, UFRJ
Chair: James Armitage, Sérgio L Felisbino
 Exhibitors Technical Conferences and Activities
13h00- 14h00
Room 205
GE Healthcare
Room 207
Nikon
Room 208
Life Technologies
14h00- 15h00
Main Hall
Bruce Alberts
University of California, San Francisco, USA
Science, Biology, and the World’s Future
Chairs: Wanderley de Souza and Denys Wheatley
 Lectures
15h15- 16h15
Room 201
L# 6
Juan Bonifacino
National Institutes of Health, Bethesda, USA
Signal-Adaptor Interactions that Mediate Polarized Sorting in
Neurons
Chair: Luis Lamberti Silva
Room 202
L# 7
Anne Eichmann
Yale University, New Haven, USA
Guidance of vascular patterning: lessons from the nervous
system
Chair: Luiz Eurico Nasciutti
Room 204
L# 8
Hans Clevers
University Medical Centre Utrecht, Utrecht, the Netherlands
Lgr5 Stem Cells in self-renewal and cancer
Chair: Vivaldo Moura Neto
28
Room 205
L# 9
Mauro Pavão
Universidade Federal do Rio de Janeiro, Brasil
Targeting protein-glycan interactions at cell surface during EMT
and hematogeneous metastasis: consequences on tumor
invasion and metastasis
Chair: Marimélia Porcionatto
Room 207
L# 10
Alejandro Schinder
Leloir Institute, Buenos Aires, Argentina
Adult-born neurons contribute to information processing in the
dentate gyrus
Chair: Flávia Gomes
16h15- 16h45 – Coffee Break
 Symposia
16h45- 18h15
Room 201
Symp #12
Protein Folding and Assembly
Chair: Carlos Ramos
Douglas M Cyr
UNC-Chapel Hill, USA
Mechanisms for folding corrector action in rescue of mutant CFTR from
premature degradation by ER Quality Control
Alberto Macario
Istituto Euro- Mediterraneo di Scienza et Tecnologia, Palermo, Italy
Chaperonopathies: Impact on protein folding and beyond
Francisco Laurindo
University of São Paulo, Brazil
Redox Processes Associated with Physicological Protein Folding and Endoplasmic
Reticulum Stress
Room 202
Symp #13
Vascular cell biology
Chair: Robson Monteiro
Joseph H McCarty
University of Texas, Houston, USA
Cell Adhesion and Signaling Pathways in Neurovascular Developmen
Jean Leon Thomas
Brain and Spinal Cord Institute, Paris, France
Vascular growth factor signaling in neurogenesis
Robson Monteiro
Institute of Medical Biochemistry, UFRJ, Brazil
Tumor-Derived Microvesicles and their Role in Cancer Progression
29
Room 204
Symp #14
Cell cycle control mechanisms
Chairs: Hugo Armelin and Patricia Gama
Leslie I Gold
New York University
Stabilizing nuclear p27kip1 with Skp2/Cks1 E3 ligase inhibitors as a potential
therapeutic intervention for endometrial cancer and other cancers
Michele Pagano
New York University, USA
Cyclin F-mediated degradation of RRM2 (Ribonucleotide Reductase family
member 2) controls genome integrity and DNA repair
Guido Lenz
Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
Resveratrol and Temozolomide co-treatment induces mitotic catatrophe and
senescence in glioma cells through modulation of mitotic regulators
Room 205
Symp #15
Migration and regeneration
Chair: Fernando Costa e Silva Filho
Mark Ginsberg
University of California, San Diego, USA
Inside- out integrin signaling
Tatiana Coelho-Sampaio
UFRJ, Rio de Janeiro, Brasil
Human-laminin mediates axonal regeneration promoted by human adipose
tissue-derived stromal cells after spinal cord injury in rats
Fernando Costa e Silva Filho
UFRJ, Rio de Janeiro, Brasil
A mechanochenical cross-talking between eukaryotic cells and their surroundings
instruct cells on what they have to do
Room 207
Symp #16
Inflammation
Chair: Patrícia Bozza
Niels O S Câmara
University of Sao Paulo, Brazil
The intimate link between fibrosis and inflammatory response
Richard Bucala
How a Parasite MIF Suppresses T cell Immunity and Influenced the Evolution of
Macrophage Responsivenes
Patrícia Bozza
Instituto Oswaldo Cruz, FIOCRUZ, Brazil
Room 208
Symp #17
Glia
Chair: Flavia A C Gomes
Arturo Ortega
Cinvestav-IPN, México DF, Mexico
GLAST/EAAT1 induces Glutamine release through SNAT3 in cultured chick
cerebellar Bergmann glial cells
30
Frank Pfrieger
University of Strasbourg, France
Understanding Neuron-Glia Interactions: Models Matter
Adan Aguirre
Stony Brook University, USA
NG2+ glial cells participate in normal brain physiology and thedevelopment of
depressive-like behaviors
18h00 – Exhibits close
18h30- 19h30
Main Hall
Ruslan Medzhitov
Inflammation: Physiology, Pathology and Evolution
Chair: Patricia Bozza
Friday, July 27
 Symposia
8h45- 10h15
Room 201
Symp #18
Perspectives in cancer therapies
Chair: Jörg Kobarg
Atanasio Pandiella
Universidad de Salamanca, Spain
Deciphering Neuregulin-HER signaling in breast cancer
Jörg Kobarg
Centro Nacional de Pesquisa em Energia e Materiais, Campinas, Brasil
Prospecting and testing new molecular target proteins for cancer therapy:
integrating systems and structural biology
Room 202
Symp #19
Regulators of neural transmission
Chairs: Vilma Martins and Roy Larson
Jeremy M Henley
University of Bristol
Regulation of neuronal function and dysfunction by protein SUMOylation
Christina Joselevitch
Gain control in the outer retina
Martin Cammarota
Instituto de Pesquisas Biomédicas, PUCRS, Porto Alegre, Brazil
31
Room 204
Symp #20
Tissue Regeneration
Chair: Juan Larrain
Ken Poss
HHMI, Duke University Medical Center, Durham, USA
Cellular and molecular mechanisms of zebrafish heart regeneration
José Garcia-Arrarás
University of Puerto Rico
Cellular and molecular mechanisms of intestinal regeneration in echinoderms
Juan Larrain
Pontificia Universidad Catolica de Chile
Spinal cord regeneration in Xenopus
Room 205
Symp #21
Metabolic Programming
Chair: James A Armitage
Patricia Lisboa
State University of Rio de Janeiro, Brazil
Smoking in the postnatal life and future obesity: the nicotine role on the
endocrine dysfunctions
Licio Velloso
University of Campinas, Brazil
Diet-induced hypothalamic inflammation in obesity
James A Armitage
Monash University, Victoria, Australia
Maternal obesity, diabetes or high fat intake in pregnancy: Are they all
independent risk factors for metabolic syndrome in her offspring?
Room 207
Symp #22
Mitochondria
Chairs and Speakers: Enilza Espreafico and Nadja Souza-Pinto
Nadja Souza-Pinto
Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo,
SP, Brazil
Mitochondrial BER activities maintain mtDNA stability and mitochondrial
function
Alicia Kowaltowski
Universidade de São Paulo, Brazil
Dietary interventions, mitochondria, oxidants and lifespan
Enilza Espreafico
Universidade de São Paulo, Ribeirão Preto, Brazil
Evidence implicating KIAA0090/CG2943 in mitochondrial function
Room 208
Symp #23
Cytotoxicity
Brazilian-Slovenian Meeting
Chairs: Sandra Azevedo and Tamara Lah Turnsec
Bojan Sedmak
National Institute of Biology, Ljubljana, Slovenia
Cyclic cyanopeptides influence cytoskeleton organization in glial cells
32
Gregor Anderluh
University of Ljubljana, Slovenia
Equinatoxin effects on cellular membranes
10h00- Exhibits open
10h15- 10h45- Break
10h45- 11h45
Main Hall
nd
2
Daniel St Johnston
University of Cambridge, UK
Polarizing perpendicular axes in Drosophila
Chair: Irene Yan
Poster Session
11h45- 12h45
Pavillion 5 (1st and 2nd floors) Poster Presentation - even numbers
12h45- 13h45
Pavillion 5 (1st and 2nd floor)
Poster Presentation - odd numbers
11h45 – SBBC General Assembly – Room 204
 Symposia- Selected Abstracts
12h15- 13h45
Room 201
Special Symposium Undergrad students selected abstracts
Wesley Luiz Barros da Silva, Fluminense Federal University
Luana De Santana Bottas, Biosciences, University of São Paulo, São Paulo, Brazil.
Lucas Antonio Duarte Nicolau, UFPI
Brenno Vinícius Martins Henrique, University of Brasília
Flavio Augusto Rocha Barbosa, Universidade Federal de Santa Catarina
Chairs: Ivarne Tersariol, Regina Goldenberg
33
Room 202
Special Symposium Graduate students selected abstracts
María Eugenia Sabatino, Universidad Nacional de Córdoba, Argentina
Eugenio Damaceno Hottz, IOC, Fiocruz
Manuela Weitkunat, Max Planck Institute of Biochemistry
Clarissa Xavier Resende Valim, FMRP, USP
Rebeca Piatniczka Iglesia, ICB, Universidade de São Paulo, Brasil
Chairs: Christina Barja-Fidalgo, Paola Casanello, Giselle Zenker Justo
 Exhibitors Technical Conferences and Activities
13h00- 14h00
Room 205
Carl Zeiss
Room 207
BD
Room 208
Roche
 Lectures
14h15- 15h15
Room 201
L# 11
Miriam Jasiulionis
Ontogeny and Epigenetics Laboratory, Pharmacology
Department, Universidade Federal de São Paulo, São Paulo,
Brazil
Epigenetic alterations: Linking sustained stress to
melanocyte malignant transformation
Chair: James Armitage
Room 202
L# 12
Stefan Linder
University Medical Center Eppendorf, Hamburg
Regulation of macrophage podosomes by microtubules and
motor proteins
Chair: Fernando Costa e Silva Filho
Room 204
L# 13
Marcelo Morales
Instituto de Biofísica Carlos Chagas Filho, Universidade Federal
do Rio de Janeiro, UFRJ, Rio de Janeiro, Brasil
Bone marrow-derived stem cell therapy attenuates lung silicosis
and lung fibrosis
Chair: Ken Wu
34
 Symposia
15h45- 17h15
Room 201
Symp #24
Cancer
Chair: Renata Pasqualini
Webster Cavenee
University of California San Diego, USA
Tumor Cell to Tumor Cell Interaction Drives Cancer Heterogeneity
Wadih Arap
The University of Texas, M D Anderson Cancer Center, USA
Targeting Adipose Tissue to Prevent Cancer Progression
Renata Pasqualini
Integration of in Vivo Phage Display & Targeted nanotechnology and Moleculargenetic Imaging
Room 202
Symp #25
Cell motility
Chair: James Sellers
Paul Selvin
University of Illinois, USA
Single Molecule Fluorescence and Optical Trapping Applied to Molecular Motors:
Two can do it better than one.
Marie-France Carlier
Cytoskeleton Dynamics and Motility group, Gif-sur-Yvette, France
Microfluidics pushes forward microscopy analysis of actin dynamics
James Sellers
National Institutes of Health, Bethesda, USA
A Tale of Two Tails: The Regulation of Myosin-5a and Myosin-7a
Room 204
Symp #26
RNA regulation
Canadian Cell Biology Society
Chairs and Speakers: Jean-Pierre Perreault and Carla Columbano
Richard B Pearson
University of Melbourne, Australia
Inhibition of RNA Polymerase I as a Strategy to Treat Cancer
Carla Columbano Oliveira
Universidade de São Paulo, Brasil
Identification of proteins regulating the RNA exosome
Jean-Pierre Perreault
Université de Sherbrooke, Canada
Impact of G-quadruplex structures on the human transcriptome
Room 205
Symp #27
Maternal interface
Chair: Estela Bevilacqua
Felipe Vadillo-Ortega
Universidad Nacional de Mexico (UNAM), Mexico
35
Paola Casanello
Faculty of Medicine, Pontificea Universidad Católica de Chile, Chile
The placenta as an early marker of genomic, proteomic and epigenetic changes
involved in vascular diseases
Graciela Panzetta
Universidad Nacional de Córdoba, Argentina
Expression and function of PSG, StarD7 and KLF6 genes in human trophoblast
cells
Room 207
Symp #28
Cells as biosensors
Chairs: Paulo Saldiva and Glaucia Santelli
Cecília Verônica Nunez
Instituto Nacional de Pesquisas da Amazônia, Manaus, Amazonas, Brazil
Cytotoxic indole alkaloids isolated from Duroia macrophylla (Rubiaceae)
Paulo Saldiva
Cellular responses to ambient levels of air pollution
Glaucia Santelli
Cell-fiber interactions: effects on cell biology
Room 208
Special Symposium – Extra Session
Bárbara Hissa de Carvalho Vieira Couto, Universidade Federal de Minas Gerais, Brasil
Ana Lúcia Vargas Arigony Corte, Universidade Federal do Rio Grande do Sul, Brasil
Daniel Moreira Silva, Universidade Federal de Uberlândia, Brasil
Raphael Silveira Vidal, Universidade Federal do Rio de Janeiro, Brasil
Eduardo Cremonese Filippi Chiela, Universidade Federal do Rio Grande do Sul
Samyra Maria dos Santos Nassif Lacerda, Universidade Federal de Minas Gerais
Chair: Marimelia Porcionatto
17h30- 18h30
Main Hall
Kennedy Shriver NICHHD, NIH, Bethesda, MD 20892
Navigating the cellular landscape with new optical probes,
imaging strategies and technical innovations
Chair: Nadja Souza-Pinto
18h00- Exhibits close
36
Saturday, July 28
 Lectures
9h00- 10h00
Room 201
L# 14
Rick Horwitz
Department of Cell Biology, University of Virginia School of
Medicine
Mechanosensing Through Myosin II: From Migration to Learning
and Memory
Chair: Christina Barja-Fidalgo
Room 202
L# 15
Stephen Doxsey
University of Massachusetts Medical School
Emerging roles of mitotic centrosomes in asymmetric events
and cilia disorders
Chair: Glaucia M M Santelli
Room 204
L# 16
Andrzej Bartke
Department of Internal Medicine, Southern Illinois University
School of Medicine, Springfield, Illinois, USA
Growth Hormone and Aging; Benefits of Endocrine Defects
Chair: Luiz Renato França
Room 205
L# 17
Sérgio Teixeira Ferreira
Institute of Biomedical Sciences, Federal University of Rio de
Janeiro, Brazil
Synapse failure induced by Alzheimer's toxic Aβ oligomers
Chair: Bernardo Castellano
 Symposia
10h30- 12h00
Room 201
Symp #29
MMPs and TIMPs
Chair: Ruy Jaeger
Stanley Zucker
Membrane Type I- Matrix Metalloproteinase (MMP14): A Multifaceted Cell
Surface Protease in Cancer
Rama Khokha
University of Western Ontario, Canada
37
Vincent Lagente
UMR991 INSERM/Université de Rennes 1, France
Role of matrix metalloproteinases and inflammasome pathway in the
development of airway inflammation and fibrosis
Room 202
Symp #30
Telomeres
Chair: Maria Isabel Cano
Maria Teresa Teixeira
Institut de Biologie Physico-Chimique, France
Saccharomyces cerevisiae as a model for the study of telomere-mediated
replicative senescence
Rodrigo Calado
Universidade de São Paulo, Ribeirão Preto, Brazil
Telomere dysfunction in human disease
Maria Isabel Cano
UNESP, Botucatu, Brazil
Searching for a CST-like complex at Leishmania spp. telomeres
Room 204
Symp #31
Cancer Stemness
Taiwan CB Society
Chair: Ken Wen Wu
Tariq Enver
University College London, UK
Ken Wen Wu
National Yang-Ming University, Taipei, Taiwan
SOX2 promotes lung cancer stemness by inducing EGFR and BCL2L1 expression
Room 205
Symp #32
Unconventional organelles
Chair: Marlene Benchimol
Martin Embley
Newcastle University, UK
Reductive evolution and the minimal mitochondria of microsporidian parasites
Kildare Miranda
Federal University of Rio de Janeiro, Brazil
Dynamic control of the contractile vacuole complex and acidocalcisomes and
their functional role in the mechanisms of regulatory volume decrease in
Trypanosomatid parasites
Ulysses Casado Lins
Federal University of Rio de Janeiro, Brazil
Cell biology of magnetotactic bacteria and their organelles: the magnetosomes
Marlene Benchimol
Universidade Santa Úrsula, Rio de Janeiro, Brazil
An unconventional organelle: the hydrogenosome
38
 Lectures
14h15- 15h15
Room 201
L# 18
Peter Friedl
Radboud University Nijmegen Medical Centre, The
Netherlands
Collective cancer invasion, tissue guidance, and plasticity of
therapy response
Chair: Marinilce F Santos
Room 202
L# 19
Xavier Belles
Institute of Evolutionary Biology (CSIC-UPF), Barcelona
Regulation of insect metamorphosis and the role of microRNAs.
Nepenthe teams up with Psyche
Chair: Klaus Hartfelder
Room 204
L# 20
Rafael Linden
UFRJ, Rio de Janeiro, Brazil
The prion protein as a prototypical cell surface scaffold protein
Chair: Vilma Martins
14h15- 15h15
Main Hall
Richard Hynes
MIT, Cambridge, USA
Extrinsic influences on tumor progression - platelets and
extracellular matrix
Chair: Hernandes F Carvalho
15h15- Main Hall- Closing Remarks
39
Travel Awards
Scientific Committee
Flavia C A Gomes (Federal University of Rio de Janeiro)
Milton Moraes (FIOCRUZ)
Hernandes de Carvalho (State University of Campinas)
Coordination: Amanda Araujo (Interevent)
Selected Students
Affiliation
Country
Adny H. Silva
Amado Quintar
Andrés Nilson Caniuguir Ortega
Anita Mayara Feitosa Santos
Bernardo Javier Krause Leyton
Carla Evelyn Coimbra Nunez
Eder Carlos Schmidt
Everton de Brito Oliveira Costa
Universidade Federal de Santa Catarina (UFSC)
Universidad de Córdoba
Perinatology Research Laboratory (PRL)
Universidade Federal do Ceará (UFC)
Perinatology Research Laboratory (PRL)
Universidade Estadual de Campinas (UNICAMP)
Centro Regional de Hemoterapia de Ribeirão
Preto
EMBRAPA / CENARGEN
Centre de Recherche en Oncologie biologique et
Oncopharmacologie
Hiroshima University
Universidad Nacional de Córdoba
Universidade Federal de São Paulo (UNIFESP)
Life and Health Sciences Research Institute
(ICVS), School of Health Sciences, University of
Minho
Institute of Molecular and Cell Biology
Universidade Federal do Pará (UFPA)
Universidade Federal do Pernambuco (UFPE)
Universidade Federal do Ceará (UFC)
Universidade Federal do Rio Grande (FURG)
Brazil
Argentina
Chile
Brazil
Chile
Brazil
Brazil
Brazil
Flavio Augusto Rocha Barbosa
Graziella Anselmo Joanitti
Luciana Pescatore Alves
Makiko Morita
María Eugenia Sabatino
Mariana Cristina Cabral Silva
Olga Catarina Lopes Martinho
Patrícia Renck Nunes
Paula Cristina Rodrigues Frade
Paulo Euzébio Cabral Filho
Priscila Briseno Frota
Renata Ottes Vasconcelos
Brazil
Brazil
France
Japan
Argentina
Brazil
Portugal
Singapore
Brazil
Brazil
Brazil
Brazil
40
Keynote Conferences- Abstracts
Skin Stem Cells in Homeostasis, Wound Repair and Cancer
Cell death
Elaine Fuchs
Howard Hughes Medical Institute, The Rockefeller University,
New York, NY, USA 10065
Douglas Green
St. Jude Children's Research Hospital, USA
Embryonic skin begins as a single layer of unspecified epithelial
cells. During development, these cells receive external cues to
undergo a series of morphogenetic events which culminate in
the production of a stratified epidermis replete with hair follicles,
sebaceous glands and sweat glands. Postnatally, each of these
tissues undergoes self-renewal which requires stem cells. We’ve
demonstrated that there are distinct populations of resident
stem cells within epithelial tissues. How these cells develop and
how they balance self-renewal and differentiation is of
fundamental importance to our understanding of normal tissue
maintenance and wound repair, and to elucidate how the
balance of growth and differentiation goes awry in cancers,
particularly squamous cell carcinomas, among the most
prevalent and life-threatening of human cancers. Using skin as
our paradigm, we’ve been dissecting how extrinsic signaling to
stem sets off a cascade of changes in transcription that governs
the activation of stem cells during tissue development,
homeostasis, hair cycling and tumorigenesis. Our findings have
provided us with new insights into our understanding of the
process of stem cell activation, and in so doing have revealed
mechanisms which are also deregulated in a variety of different
human cancers. In this talk, I will review some of our studies that
implicate a complicated cross-talk between stem cells and their
niche microenvironment, and how these communication
circuitries change in normal homeostasis and wound repair and
in tumor progression.
Science, Biology, and the World’s Future
Inflammation: Physiology, Pathology and Evolution
Bruce Alberts
Professor Emeritus of Biochemistry and Biophysics, University of
California, San Francisco; Editor-in-chief, Science magazine;
United States Science Envoy
Ruslan Medzhitov, Ph.D.
David W. Wallace Professor of Immunobiology
Investigator, Howard Hughes Medical Institute
Yale University School of Medicine
New Haven, CT USA
There are many exciting challenges ahead for biologists. Living
organisms are so complicated that we will need new methods of
analysis to achieve any deep understanding of their molecular
mechanisms. For example, even when we have determined each
of the hundreds of different molecular interactions that create
the actin cytoskeletal system, and know the three-dimensional
structures and rate constants for the formation and disassembly
of each of its possible sub-complexes, the challenge of
computing the outcomes will remain. In the same sense, most of
the interesting properties of cells and organisms are “emergent
properties”, resulting from a large network of interactions that
have non-intuitive outcomes.
More broadly, the knowledge and the problem-solving skills of
scientists are critical for every nation – no matter how rich or
poor. Thus, for example, science has produced a deep
understanding of the natural world that often enables an
accurate prediction of the consequences of current actions on
the future. In addition, every society needs the values of
science: honesty, generosity, and an insistence on evidence
while respecting all ideas and opinions regardless of their source
of origin. To spread such values, science education needs to be
redefined at all levels, with much less emphasis on the
memorization of science facts and terms. Instead, we should be
providing empowering experiences in problem-solving that take
advantage of the curiosity that children bring to school and
increase a student’s understanding of the world. Closely related
changes in the introductory science courses in college,
emphasizing “science as a way of knowing,” are the key to
driving these reforms.
Inflammation is an adaptive response to noxious conditions that
disrupt tissue homeostasis. The inflammatory response alters
the functional state of target tissues and organs aiming to
eliminate the inflammatory inducers and to restore homeostasis.
This unavoidably occurs at the expense of normal tissue function
thereby creating a potential for pathological alterations. In
addition, inflammatory control mechanisms are generally
antagonistic to the homeostatic control mechanisms. Therefore,
the inflammatory response presents a fundamental trade-off
between host protection and inflammatory pathology. This
trade-off was optimized under environmental conditions that are
no longer present for most modern human populations and was
shaped by evolutionary priorities that are no longer relevant for
most humans suffering from inflammatory diseases.
Understanding the evolutionary and physiological roots of the
inflammatory response will help to develop prophylactic and
therapeutic better strategies for the prevention and treatment
of modern human diseases.
41
Polarizing perpendicular axes in Drosophila
Daniel St Johnston
The Gurdon Institute, University of Cambridge, UK
Almost all cells in a multicellular organism must be polarized to
perform their normal functions, while a loss of polarity is a
hallmark of cancer. Work over the last decade has revealed that
a conserved set of polarity (PAR) proteins define complementary
cortical domains in all polarized cell-types examined so far. How
these complementary domains are established is much less well
understood, however, with the exception of the C. elegans
zygote. We have analyzed how the similar PAR domains form in
the Drosophila oocyte to define the anterior–posterior axis (AP)
of the embryo. Our results reveal that the oocyte is polarized by
a different mechanism from the C. elegans zygote that also
appears to operate in epithelial cells. Nevertheless, the
organizing principles that underlie polarity seem to be
conserved.
The dorsal-ventral (DV) axis is also defined by the polarized
organization of the oocyte, in this case by the movement of the
nucleus from the posterior cortex of the oocyte to its
anterior/lateral border. Although the movement of the oocyte
nucleus was thought to depend on the prior establishment of AP
polarity, we have isolated a mutant that separates these two
processes. More importantly, live imaging reveals a novel
mechanism of nuclear movement. This reveals that the oocyte
has two parallel polarity systems and leads to a revised view of
how orthogonal AP and DV axes form.
Navigating the cellular landscape with new optical probes,
imaging strategies and technical innovations
Eugene Kennedy Shriver National Institute of Child Health and
Human Development, National Institutes of Health, Bethesda,
MD 20892
Emerging visualization technologies are playing an increasingly
important role in the study of numerous aspects of cell biology,
capturing processes at the level of whole organisms down to
single molecules. Recent developments in probes, techniques,
microscopes and quantification are dramatically expanding the
areas of productive imaging. Photoactivatable fluorescent
proteins (PA-FPs) have been particular fruitful in this regard.
They become bright and visible upon being exposed to a pulse of
UV light. This allows selected populations of proteins to be pulselabeled and tracked over time. Used for in cellulo pulse chase
experiments, the PA-FPs have helped clarify mechanisms for
biogenesis, targeting, and maintenance of organelles as separate
identities within cells. PA-FPs have further permitted the
development of single molecule-based superresolution (SR)
imaging, which dramatically improves the spatial resolution of
light microscopy by over an order of magnitude (~10-20 nm
resolution). Involving the controlled activation and sampling of
sparse subsets of photoconvertible fluorescent molecules, single
molecule SR imaging offers exciting possibilities for obtaining
molecule scale information on biological events occurring at
variable time scales. Here, I discuss the new fluorescent imaging
techniques and the ways they are helping researchers navigate
through the cell to unravel long-standing biological questions.
Extrinsic influences on tumor progression - platelets and
extracellular matrix
Richard Hynes
Howard Hughes Medical Institute, Koch Institute, MIT,
Cambridge, MA 02139, USA. [email protected]
Intrinsic changes in tumor cells contribute to metastatic
potential, but influences from the surrounding environment also
play important roles.
We have shown that platelets actively promote invasive and
malignant behavior of tumor cells by activating signal
transduction pathways (TGF- /SMAD and NF B) within the
tumor cells and enhancing invasive behavior, extravasation and
metastasis. Platelets form aggregates around tumor cells that
also recruit leukocytes, which further enhance malignancy.
Alterations in extracellular matrix (ECM) occur during normal
development and in pathologies such as fibrosis, skeletal
diseases and cancer. Despite clear indications that tumor ECM
and its interactions with cells play important roles in tumor
progression, we do not have a good picture of ECM composition,
origins and functions in tumors. One reason lies in the
biochemical properties of ECM proteins (large size, insolubility,
cross-linking, etc.) that render attempts to characterize ECM
composition very challenging.
We have developed proteomics-based methods coupled with
bioinformatic definition of the “matrisome” (ECM and ECMassociated proteins) to analyze the protein composition of tissue
extracellular matrices. We have characterized the ECMs of
normal tissues and of non-metastatic and metastatic tumors. We
have applied this approach to understand the origins of tumor
ECM and shown that both tumor cells and stromal cells
contribute to significant changes in the ECMs of tumors of
differing metastatic potential. We have begun to apply this
approach to human patient material to characterize the ECM
composition of tumors of varying prognosis with the goal of
developing ECM signatures that may be of diagnostic and/or
prognostic value.
42
Lectures- Abstracts
L#1
The ribosome-associated E3 ubiquitin ligase, Listerin (Ltn1), is
implicated in neurodegeneration and mediates a novel
pathway of protein quality control
Claudio Joazeiro
The Scripps Research Institute, La Jolla, CA
mRNA lacking stop codons ('non-stop mRNA') can arise from
errors in gene expression, and encode aberrant proteins whose
accumulation could be deleterious to cellular function. In
bacteria, these 'non-stop proteins' become co-translationally
tagged with a peptide encoded by ssrA/tmRNA (transfermessenger RNA), which signals their degradation by energydependent proteases. How eukaryotic cells eliminate non-stop
proteins remained unknown. We have recently reported that
the S. cerevisiae Ltn1 RING-domain-type E3 ubiquitin ligase acts
in the quality control of non-stop proteins (Bengtson & Joazeiro
2010. Nature 467:470-3). The Ltn1-mediated process is
mechanistically distinct but conceptually analogous to that
performed by ssrA: Ltn1 is predominantly associated with
ribosomes, and marks nascent non-stop proteins with ubiquitin
to signal their proteasomal degradation. Ltn1-mediated
ubiquitylation of non-stop proteins seems to be triggered by
their stalling in ribosomes on translation through the poly(A)
tail. The biological relevance of this process is underscored by
the finding that loss of Ltn1 function confers sensitivity to stress
caused by increased non-stop protein production. We speculate
that defective protein quality control may underlie the
neurodegenerative phenotype that results from mutation of the
mouse Ltn1 homologue, Listerin. In my talk, I will review these
data and will present recent findings and further
characterization of the Listerin/Ltn1 pathway.
L#2
Excessive mitochondrial fission mediated by PKC and by Drp1
activation; new targets for neuroprotection
Daria Mochly-Rosen1, Marie-Helene1 Distanik and Xin Qi1.2
1
Department of Chemical and Systems Biology, Stanford
University School of Medicine, Stanford, CA, USA. 2Current
address: Department of Physiology, Center for Mitochondrial
Diseases, Case Western Reserve University School of Medicine,
Cleveland, OH, USA
Neuronal cell death in a number of neurological disorders is
associated with aberrant mitochondrial dynamics and
mitochondrial degeneration. However, the triggers for this
mitochondrial dysregulation are not known. We found that
activation of  protein kinase C (PKC) induced aberrant
mitochondrial fragmentation and impaired mitochondrial
function in neurons in an in vivo rat model of hypertensive
encephalopathy. We found that PKC directly bound to Drp1, a
major mitochondrial fission protein, and phosphorylated it at
Ser 579, thus increasing mitochondrial fragmentation.
Importantly, inhibition of PKC, using a selective PKC inhibitor
peptide that we have designed, reduced impaired
mitochondrial fission and conferred neuronal protection in
models of hypertensive encephalopathy. We also found that
this PKC inhibitor reduced mitochondrial dysfunction in
models of Parkinsonism. Together, we show that PKC
activation dysregulates the mitochondrial fission machinery and
increases ROS production, thus contributing to at least two
neurological pathologies by increasing mitochondrial fission,
fragmentation and dysfunction. Since PKC may be critical for
other cellular functions, we next focused on generating an
inhibitor of Drp1 interaction with Fis1. Applying a rationally
designed approach, we identified P110, a peptide inhibitor of
Drp1/Fis1 interaction, and show that this peptide is highly
effective and selective in inhibiting aberrant mitochondrial
fission in neurons and cell death induced by neurotoxins, such
as those associated with Parkinsonism. Therefore, we suggest
that inhibitors of aberrant mitochondrial fission might be useful
for treatment of human diseases in which dysregulation of
mitochondrial dynamics occurs.
43
L#3
New approaches for correlated LM and 3D EM applied to
MULTISCALE CHALLENGES: Bridging Gaps in Knowledge and
Understanding
Mark H. Ellisman, Ph.D.,
Professor of Neurosciences and Bioengineering; Director, the
National Center for Microscopy and Imaging Research (NCMIR)
(http://www.ncmir.ucsd.edu/) UCSD.
A grand goal in cell biology is to understand how the interplay
of structural, chemical and electrical signals in and between
cells gives rise to tissue properties, especially for complex
tissues like nervous systems. New technologies are hastening
progress as biologists make use of an increasingly powerful
arsenal of tools and technologies for obtaining data, from the
level of molecules to whole organs, and at the same time
engage in the arduous and challenging process of adapting and
assembling data at all scales of resolution and across disciplines
into computerized databases. This talk will highlight projects in
which development and application of new contrasting
methods and imaging tools have allowed us to observe
otherwise hidden relationships between cellular, subcellular
and molecular constituents of cells, including those of nervous
systems. New chemistries for carrying out correlated light and
electron microscopy will be described, as well as recent
advances in large-scale high-resolution 3D reconstruction with
LM, TEM and SEM based methods. Examples of next
generation cell-centric image libraries and web-based
multiscale information exploration environments for sharing
and exploring these data will also be described.
L#4
Dynamics of gene expression in real-time measured on single
genes in single living cells
Yaron Shav-Tal
The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan
University, Ramat Gan, Israel
How can the transcriptional output of a gene be measured in a
living cell? One approach is to measure transcriptional kinetics
on multiple-copy gene-arrays by quantifying the rates at which
fluorescently tagged mRNA is produced. This technique can
provide accurate rates of transcription elongation in vivo.
Another system allows the detection of transcriptional gene
activity from a single gene, thereby providing the ability to
analyze the kinetics of gene expression at the single allele level.
This analysis can discern between endogenous and overexpressed states of a gene, and provide spatial and temporal
information on transcription throughout the cell cycle.
44
L#5
PfCBF transcription factor, a new player for signal transduction
in melatonin-pathways in malaria parasites
L#6
Signal-Adaptor Interactions that Mediate Polarized Sorting in
Neurons
Wania Rezende Lima, Miriam Moraes and Célia R. S. Garcia
Departamento de Fisiologia, Instituto de Biociências,
Universidade de São Paulo – São Paulo- Brasil
Ginny G. Farías, Loreto Cuitino, Xiaoli Guo, Xuefeng Ren, Rafael
Mattera and Juan S. Bonifacino
Cell Biology and Metabolism Program, Eunice Kennedy Shriver
National Institute of Child Health and Human Development,
National Institutes of Health, Bethesda, Maryland, USA
The signal transduction pathways controlling malaria parasite
development remain largely unexplored. It is now accepted that
Plasmodium senses the environment and exploits calcium and
cAMP signalling pathways to modulate cellular functions. We
want to understand how the molecular machinery for signalling
transduction is put in action in Plasmodium, how second
messengers are generated and if they play a role in the cell
cycle. We have reported that potentially important signaling
molecules from the host cell, the Red Blood Cell (RBCs) such as
ATP modulates Plasmodium falciparum progression within RBCs
through the rise of cytosolic Ca2+. We have used a cell-permeant
form of caged-IP3 to investigate the cytosolic IP3 levels under
physiological conditions in infected RBCs co-loaded with both
the cell-permeant caged-IP3 and Fluo4-AM. UV flash photolysis
of caged-IP3 under these conditions elicited a rapid and
transient increase in intracellular Ca2+ in RBCs infected with P.
falciparum. Thereby providing a direct evidence that a classical
PLC-dependent intracellular Ca2+ release pathway operates in P.
falciparum infected RBCs. We provided the first direct evidence
that the host hormone melatonin elicits a rise in intracellular IP3
levels in the malaria parasite. We have also found that the
Plasmodium kinase PfPK7 is central in the downstream
mechanism for synchronizing the parasite as a P. falciparum
clone unable to express PfPK7 does not respond to melatonin.
Taken together these data implicate that melatonin activates
Phospholipase C (PLC) to generate IP3 and open ER-localized IP3sensitive Ca2+ channels in P. falciparum
In our search for the molecular effectors of second messenger
signaling in P. falciparum we have search for the role of the
PfCBF. The CBF family of transcription factors are involved in
the regulation of cell cycle of many eukaryotic genes. The
molecular and functional characterization of transcription
factors in P. falciparum are yet poorly studied. In order to
determine the protein and mRNA expression levels of intraerythrocytic PfCBF, western-blot and qRT-PCR were performed.
To localize the CBF protein distribution in the parasite, confocal
microscopy and subcellular fractionation were carried out. The
effect cAMP on PfCBF gene and protein expression during intraerythrocytic development of the malaria parasites was followed
by qRT-PCR and western blot analysis. PfCBF is expressed
throughout the intra-erythrocytic stages but is greatly
detectable at the schizont stage at both the mRNA and protein
levels.
In conclusion, We suggest that PfCBF may have an integral role
in parasite melatonin responses and the subsequent parasite
development. Then progress in understanding the function of
PfCBF transcription factor in the context of the melatonin
response is likely to provide a better knowledge of the parasite
biology.
Neurons are anatomically and functionally polarized cells that
conduct nerve impulses in a vectorial fashion. Impulses are
received by dendrites, propagated through the soma, and
eventually transmitted to other cells by axons. The plasma
membrane of each of these neuronal domains has a distinct
protein composition, but the mechanisms responsible for this
differential distribution of plasma membrane proteins remain
poorly understood. By analogy to other protein sorting
processes, we hypothesized that biosynthetic delivery of
transmembrane proteins to different neuronal domains could
be mediated by interaction of sorting signals in the cargo
proteins with adaptor proteins that are components of protein
coats. Indeed, we found that a tyrosine-based sorting signal in
the cytosolic domain of the transferrin receptor (TfR) mediates
sorting of this protein to the somatodendritic domain in both
hippocampal and cortical neurons. This signal binds to the
mu1A subunit of the clathrin-associated, heterotetrameric
adaptor protein 1 (AP-1) complex. Overexpression of a
dominant-negative mu1A mutant incapable of binding signals,
or RNAi-mediated depletion of another subunit of the AP-1
complex, gamma-adaptin, resulted in missorting of the TfR to
the axon. Various microscopic techniques revealed that sorting
occurs at AP-1-coated areas of the TGN through exclusion of the
TfR from transport carriers bound for the axon. These findings
demonstrate that interactions of sorting signals with AP-1
mediate clathrin-dependent sorting of the TfR and other cargos
to the neuronal somatodendritic domain. Together with recent
observations in other polarized cell types, our findings support
the notion that AP-1 is a global regulator of polarized sorting.
45
L#7
Guidance of vascular patterning: lessons from the nervous
system
Anne Eichmann
Centre Interdisciplinaire de Recherche en Biologie (CIRB),
Collège de France, Paris, France, Cardiovascular Research
Center, Yale University School of Medicine, 300 George Street,
New Haven, CT 06510-3221, USA
Anatomical parallels between the nervous and the vascular
system are readily apparent in peripheral body tissues, where
blood vessels and nerves ramify throughout nearly all domains
of the body and are usually aligned. Alignment of nerves and
blood vessels allows the establishment of a physical relationship
between them, as larger nerves are vascularized by vasa
nervorum to ensure their oxygen and nutriment supply, while
arteries are innervated by autonomic nerve fibers that control
vascular tone. To orchestrate the formation of their highly
branched, exquisitely wired networks, nerves and blood vessels
have developed shared cellular and molecular principles.
L#8
Lgr5 Stem Cells in self-renewal and cancer
Hans Clevers
Hubrecht Institute, Royal Netherlands Academy of Arts and
Sciences & University Medical Centre Utrecht, Uppsalalaan 8,
3584 CT Utrecht, the Netherlands
The intestinal epithelium is the most rapidly self-renewing
mammalian tissue. Lgr5 is a gene transcribed in cycling, crypt
base columnar cells at the crypt base. Using lineage tracing
experiments the Lgr5+ve cells were identified as the stem cells of
the intestinal epithelium. Furthermore, Lgr5+ve stem cells can
initiate ever-expanding organoids in vitro. The Lgr5+ve stem cell
hierarchy of differentiation is maintained in these organoids.
Thus, intestinal crypt-villus units can be built from a single stem
cell in the absence of a non-epithelial cellular niche.
Although, Lgr5 stem cells persist life-long, crypts drift toward
clonality quickly. The cellular dynamics are consistent with a
model in which the stem cells divide symmetrically, and
stochastically adopt stem or transient amplifying cell fates after
cell division.
Lgr5 stem cells are interspersed between differentiated Paneth
cells, which produce all essential signals for stem-cell
maintenance. Co-culturing of sorted stem cells with Paneth cells
dramatically improves organoid formation. Genetic removal of
Paneth cells in vivo results in the concomitant loss of Lgr5 stem
cells.
Intestinal cancer is initiated by Wnt pathway-activating
mutations in genes such as APC. Deletion of APC in stem cells,
but not in other crypt cells results in neoplasia, identifying the
stem cell as the cell-of-origin of adenomas. Moreover, a stem
cell/progenitor cell hierarchy is maintained in stem cell-derived
adenomas, lending support to the “cancer stem cell”-concept.
46
L#9
Targeting protein-glycan interactions at cell surface during
EMT and hematogeneous metastasis: consequences on tumor
invasion and metastasis
Mauro S. G. Pavao, Eliene O. Kozlowski and Felipe C. O. B.
Teixeira
Instituto de Bioquímica Médica, Universidade Federal do Rio de
Janeiro (UFRJ), Rio de Janeiro, Brasil
Two critical moments of carcinoma invasion and metastasis are
the epithelial to mesenchymal transition (EMT), which occurs in
the primary tumor and the hematogeneous metastasis, which
occurs in the vascular system. Stromal growth factors and cell
sulfate heparan sulfate proteoglycans (HSPG) are key mediators
of EMT, whereas tumor cell surface glycans and P-selectin on
activated platelets are essential for hematogeneous metastasis.
Cell surface HSPG are co-receptors for the binding of several
growth factors to their receptors involved in EMT and tumor
dissemination. Two families of HSPGs carry the majority of the
heparan sulfate on cells: glypicans and syndecans.
Hematogeneous metastasis of cancer cells is a cascade of
events involving the intravasation of tumor cells into the
bloodstream, evasion of innate immune surveillance, adhesion
to vascular endothelium of distant organs and colonization of
tissues. During this process, the interaction of tumor cell
surface glycans and platelet P-selectin creates complexes that
allows tumor cells to evade the immune defenses and
eventually colonize distant organs. Previous work from our lab
suggest that the unique glycosaminoglycans from marine
invertebrates may attenuate the response of tumor cells to
growth factor–mediated EMT in the primary tumor and Pselectin-mediated formation of tumor cell-platelet complex
during hematogeneous metastasis. As a consequence, tumor
cell dissemination can be drastically reduced.
L#10
Adult-born neurons contribute to information processing in
the dentate gyrus
Alejandro F. Schinder
Laboratory of Neuronal Plasticity, Leloir Institute (IIBBACONICET), Buenos Aires
The adult dentate gyrus generates new granule cells (GCs) that
develop over several weeks and integrate into the preexisting
network. While adult hippocampal neurogenesis has been
implicated in learning and memory, the specific role of new GCs
remains unclear. Is it solely the continuous addition of new
neurons to the network what is important, or are there unique
functional properties only attributable to new GCs that are
relevant to information processing? While developing,
immature GCs display elevated intrinsic excitability, reduced
GABAergic inhibition and a capacity to undergo activitydependent synaptic potentiation. Such high intrinsic excitability
would potentially allow immature GCs to be activated by
entorhinal afferents in spite of their low density of
glutamatergic inputs. It has thus recently been hypothesized
that immature GCs might be critical to hippocampal function.
We have recently examined whether immature adult-born
neurons contribute to information encoding. Combining
calcium imaging and electrophysiology in acute slices we found
that weak afferent activity recruits few mature GCs while
activating a substantial proportion of the immature neurons.
These different activation thresholds are dictated by an
enhanced excitation/inhibition balance that is transiently
expressed in immature GCs. In addition, immature GCs exhibit
low input specificity that switches with time towards a highly
specific responsiveness. Therefore, activity patterns entering
the dentate gyrus can undergo differential decoding by a
heterogeneous population of GCs originated at different times.
47
L#11
Epigenetic alterations: Linking sustained stress to melanocyte
malignant transformation
L#12
Regulation of macrophage podosomes by microtubules and
motor proteins
Miriam Galvonas Jasiulionis
Ontogeny and Epigenetics Laboratory, Pharmacology
Department, Universidade Federal de São Paulo, São Paulo,
Brazil
Stefan Linder
University Medical Center Eppendorf, Hamburg
As other tumor types, both genetic and epigenetic alterations
seem to contribute to melanoma genesis. Consistent evidences
have suggested the key role of epigenetic marks in the genesis
of pathologies induced by chronic stress. Increased levels of
reactive oxygen species (ROS), caused for example by chronic
inflammation, aging or UV radiation, might be responsible for
abnormal epigenetic marks, which might significantly
contribute to melanoma development. In this way, the study of
the relationship among sustained stress, aberrant epigenetic
marks and melanocyte malignant transformation may help to
comprehend the mechanisms involved in melanoma genesis
and, also, open new avenues to the development of new
therapeutic strategies. Our laboratory established a murine
model of melanocyte malignant transformation associated with
sustained stress conditions. Progressive morphological and
molecular alterations, which lead to the acquisition of
malignant phenotype, were observed after submitting nontumorigenic melanocytes to sequential cycles of anchorage
blockade. In this way, pre-malignant melanocytes
corresponding to intermediate phases of malignant
transformation (1C, 2C, 3C and 4C), and different melanoma
cell lines, both non-metastatic (4C3- and 4C11-) and metastatic
(4C3+, 4C11+, Tm1 e Tm5), were obtained from the nontumorigenic melanocyte lineage melan-a. Data from our group
demonstrated that melan-a anchorage blockade results in
oxidative stress and that increased levels of superoxide anion
are related to global DNA hypermethylation and increased
levels of Dnmt1 protein observed in this condition. We have
been studied molecular mechanisms underlying alterations of
epigenetic marks by ROS and the impact of this modulation on
melanocyte malignant transformation.
Podosomes are actin-based matrix contacts in a variety of cell
types, most notably monocytic cells, and are characterized by
their ability to lyse extracellular matrix material. Besides their
dependence on actin regulation, podosomes are also contacted
by microtubule plus ends and are influenced by microtubuledependent transport processes.
This talk will highlight the role of microtubules and motor
proteins in the regulation of podosome turnover and podosomal
matrix degradation in primary human macrophages. A particular
focus will be on the role of kinesin motors and the transport of
the matrix metalloproteinase MT1-MMP. A further topic will be
the differential regulation of podosome subpopulations, and
especially the influence of the actomyosin system in podosome
turnover.
48
L#13
Bone marrow-derived stem cell therapy attenuates lung
silicosis and lung fibrosis
L#14
Mechanosensing Through Myosin II:
Learning and Memory
Marcelo Morales
Instituto de Biofísica Carlos Chagas Filho, Universidade Federal
do Rio de Janeiro, UFRJ, Rio de Janeiro, Brasil
Rick Horwitz, Miguel Vicente-Manzanares, Lingfeng Chen,
Jennifer Hodges, Karen Litwa, Kris Kubow, and Alexia Bachir
Department of Cell Biology, University of Virginia School of
Medicine
Silicosis is an occupational disease produced by the deposition
of silica particles in the lungs, which causes respiratory failure
due to a fibrotic reaction. There is no effective treatment for
silicosis, other than the cessation of the causative exposure.
We showed in animal models of silicosis that bone marrow
stem cell therapy is efficient to prevent the development of
granulomas and attenuates the inflammatory process. In
patients we reported the time course of lung perfusion
scintigraphy of five patients with silicosis treated with
intrabronchial instillation of autologous bone marrow derived
mononuclear cells through bronchoscopy and this procedure
showed to be safe with benefits to the lungs. These results
open the opportunity for further studies in patients and
possible use of this new technology for the treatment of lung
silicosis.
From Migration to
Myosin II (MII) generates and interprets mechanical cues and
thereby participates in a signaling loop that regulates diverse
cellular processes. In cell migration, MII is a downstream target
of Rho GTPases and major regulator of protrusion, adhesion,
and polarity. We have recently identified new modes of MII
regulation - novel tyrosine phosphorylation sites in the
regulatory light chain and a cluster of phosphorylation sites in
the tail region of the heavy chain - that modify its contractile
and bundling properties. Most migration studies have utilized
αvβ3 or α5β1 integrins, which serve as receptors for vitronectin
and fibronectin. We have now extended this to other cell types
and integrins. On the one hand myosin II plays an analogous
role in the organization of dendritic spines and the postsynaptic
density in hippocampal neurons during their development and
response to stimulation. On the other, its role is greatly
diminished in cells using the α6β1 or αLβ2 integrins. In these
cells, the apparent affinity between integrin and its ECM leads to
a novel molecular fluxing of integrins in adhesions. This results
in reduced force transmission to the substrate, enhanced
signaling, and increased directional migration.
For cells
migrating in 3D, the role of MII is modulated by the organization
of the surrounding matrix resulting in the characteristic
adhesion profiles observed in 3D. Finally, the effect of MII on
adhesions is being studied using correlation microscopy and
cryoEM.
49
L#15
Emerging roles of mitotic centrosomes in asymmetric events
and cilia disorders
Stephen Doxey
University of Massachusetts Medical School , Department
Program in Molecular Medicine University of Massachusetts
Medical School 373 Plantation Street Worcester MA 01605
Mitosis is a fundamental process required for cell proliferation
in all multicellular organisms. Much has been learned about
the underpinnings of this process over the last century, but
new and unexpected insights continue to be uncovered. Here
we describe two novel and unanticipated findings associated
with mitosis. The first is the unexpected identification of
mitotic functions for proteins long known to function in cilia
formation and ciliopathies. We show that the cilia proteins
IFT88, IFT20 and IFT57 play a crucial role in the organization of
spindle poles. Their depletion disrupts astral microtubules and
misorients spindles. This has important implications for
cystogenesis that accompanies ciliopathies. A second study
shows that the midbody, a singular organelle formed between
dividing daughter cells, is inherited by one daughter cell rather
than being lost as a remnant or residual body as previously
believed. Midbodies are inherited asymmetrically by the
daughter cell with the older centrosome. Disruption of the
older centrosome randomizes midbody inheritance. Midbodies
accumulate in stem cells and cancer ‘stem cells’ but not in
normal or differentiating cells. In differentiating cells midbodies
are degraded by receptor-mediated autophagy; stem cells and
cancer stem cells evade autophagic degradation. Midbody
enrichment by blocking degradation enhances reprogramming
to induced pluripotent stem cells and increases in vitro
tumorigenicity of cancer cells. These results reveal unexpected
post-mitotic roles for midbodies in stem cells and cancer ‘stem
cells’.
L#16
Growth hormone and aging; benefits of endocrine defects
Andrzej Bartke
Department of Internal Medicine, Southern Illinois University
School of Medicine, Springfield, Illinois, USA
Growth hormone (GH) levels progressively decline after reaching
maximal levels in early adulthood and it was suspected that this
decline may represent one of the causes of aging. Surprisingly,
mice with mutations that cause GH deficiency and mice with
targeted deletion of GH receptors live much longer than their
normal siblings and exhibit symptoms of delayed aging.
Extended longevity of these mutants is associated with reduced
growth and adult body size, improved maintenance of
pluripotent bone marrow stem cells, reduced incidence of
cancer, increased fibroblast resistance to various cytotoxic
stressors and various metabolic changes. Circulating levels of
insulin and glucose are reduced and insulin sensitivity measured
by insulin tolerance tests is enhanced. In GH receptor deleted
(GHRKO) mice improved whole animal insulin sensitivity has
been related to increased levels and phosphorylation of hepatic
insulin receptors and reduced inhibitory (Serine 307)
phosphorylation of IRS-1. mTOR signaling likely contributes to
this change in IRS-1 phosphorylation. Results of surgical
removal of intraabdominal adipose tissue indicate that
adiponectin secreted by these fat depots enhances insulin
sensitivity of long-lived GH-related mutants. Metabolic shifts in
GH-deficient and GH-resistant mice also include increased
oxygen consumption and reduced respiratory quotient, implying
increased reliance on lipids as metabolic fuel. In sum,
suppression of GH signals slows aging in mice by multiple
mechanisms. Supported by NIA.
50
L#17
Synapse failure induced by Alzheimer's toxic Aβ oligomers
Sérgio Teixeira Ferreira
Biomedical Sciences Institute, Federal University of Rio de
Janeiro (UFRJ), Rio de Janeiro, Brazil
More than one hundred years after its original description, the
mechanisms leading to memory loss and progressive cognitive
impairment in Alzheimer’s disease (AD) remain controversial.
Considerable evidence accumulated during the past decade
implicates soluble oligomers of the amyloid-β peptide (Aβ),
which accumulate in the brains of AD patients, as the proximal
toxins that attack neurons and cause synapse failure
culminating with memory impairment. This presentation will
focus on mechanisms by which Aβ oligomers (AβOs) attack
synapses and negatively impact the function of neuronal
receptors important for synaptic plasticity. We recently
showed that AβOs cause aberrant activation of NMDA
receptors, which triggers dysregulation of intracellular Ca2+
levels, neuronal oxidative stress and receptor internalization.
Similarly, AβOs induce removal of AMPA receptors from
synapses. Along with changes in pre-synaptic neurotransmitter
vesicle release, combined removal of NMDA and AMPA
receptors from synapses may be part of the mechanism by
which AβOs inhibit synaptic plasticity. We also demonstrated
that NMDA receptors play a key role in the binding of Aβ
oligomers to a neuronal receptor complex that putatively
comprises additional protein components, among which the
cellular prion protein. Finally, our recent work has shown that
A Os inhibit neuronal insulin signaling, essential for neuronal
survival, synaptic plasticity and memory formation. Elucidation
of molecular/cellular mechanisms underlying the deleterious
impact of AβOs on synapses may illuminate the development
of novel therapeutic approaches to combat memory loss in AD.
Key words: synaptotoxicity, amyloid- , memory loss
L#18
Collective cancer invasion, tissue guidance, and plasticity of
therapy response
Peter Friedl1,2
1 Radboud University Nijmegen Medical Centre, Nijmegen, The
Netherlands and
2 The University of Texas, MD Anderson Cancer Center,
Houston, TX, USA
The tumor microenvironment contributes to cancer invasion,
growth and survival with impact on tumor response to therapy.
We here employ intravital infrared multiphoton imaging for the
multi-parameter visualization of cancer invasion, guidance by
the tumor stroma, and therapy response. The data show
predominantly collective cancer cell into the host stroma at
speeds of up to 200 µm per day. Invasion resulted from nondestructive contact-guidance type migration exploiting
preformed tracks of multi-interface topography, including 1D,
2D and 3D dimensionalities, but was independent of β1 and β3
integrin-mediated mechanotransduction. Collective invasion
was coupled to altered survival capability, withstanding highdose radiotherapy and forming a resistance niche for
subsequent relapse of the disease. Albeit invasion was integrinindependent, invasion-associated radioresistance was sensitive
to the β1/β3 integrin targeting by RNAi or antiantibody treatment, resulting in anoikis induction and regression
of both, tumor lesion and invasion strands. In conclusion,
collective invasion is an important invasion mode in solid tumors
that receive integrin signals from the tissue microenvironment
for acquiring an altered phenotype and improved survival.
51
L#19
Regulation of insect metamorphosis and the role of
microRNAs. Nepenthe teams up with Psyche
Xavier Bellés
Institute of Evolutionary Biology (CSIC-UPF), Barcelona
E-mail: [email protected]
Insect metamorphosis has fascinated mankind since the time of
Aristotle, some two thousand years ago. But it was not until
the decade of 1930 that the studies of Vincent B. Wigglesworth
showed that insect metamorphosis is regulated by two
hormones: the molting hormone, which induces the successive
molts, and the juvenile hormone, which maintains the juvenile
character of them. Then, a number of transcription factors act
as mediators of these hormones, as well as a number of target
genes that codify for proteins, giving the shape and behaviour
of a juvenile or an adult stage. Working on the cockroach
Blattella germanica, we found that microRNAs, which are RNAs
of ca. 22 nucleotides that play a repressing action on mRNA,
have a key role in metamorphosis. We silenced the expression
of dicer-1 (a ribonuclease that mediates the maturation of
microRNAs) in the last nymphal instar and the cockroaches,
instead of molting to the adult stage, transformed into
supernumerary nymphs. We presume that there are
microRNAs that repress the expression of genes that maintain
the juvenile status quo (like Nepenthe, the drug of
forgetfulness of the Greeks). This leads to a change of genetic
program, from juvenile to adult and, within the latter, there
must be other microRNAs that modulate and refine the
expression of genes that give rise to the adult animal, thus
making it all right (like Psyche, the Greek symbol of
transformation and new life).
L#20
The prion protein as a prototypical cell surface scaffold protein.
Rafael Linden
Instituto de Biofísica da UFRJ, Rio de Janeiro, Brazil.
Based on multiple interaction partners and pleiotropic signaling
properties, we proposed the hypothesis that the prion protein
(PrPC) is a cell surface scaffold protein, that serves as a dynamic
platform for the assembly of signaling modules involved in
widespread systemic functions. Our recent work is focused on 3
topics: (a) identification and validation of additional molecular
interactions of PrPC; (b) structural evidence for allosteric
function of PrPC; (c) functional properties and dysfunction of
PrPC beyond the nervous system. A phage display screen,
together with evidence from PrPC-null mice, implicate several
neurotransmitter receptors and/or transporters in PrPCdependent signaling; Biophysical techniques showed that
interaction of PrPC with its ligand hop/STI1 entails reciprocal
structural remodeling, and strongly suggest allosteric effects
that may be involved in the propagation of signals through PrPCmediated multiprotein complexes; Beyond the nervous system,
we found that both peripheral inflammation and behavioral
stress modulate the content of PrPC at the plasma membrane of
neutrophils, with consequences upon peroxide-dependent
cytotoxicity towards vascular endothelial cells. Our studies add
to the understanding of both allosteric properties of the prion
protein and systemic control of its expression and function. The
data are consistent with the scaffold hypothesis that explains
the multiple roles of the prion protein in physiology and
pathology, and further suggest that PrPC may be relevant for
clinically observed associations of stress and anxiety with either
the severity or the progression of various degenerative/
noncommunicable diseases.
(Supported by CNPq, FAPERJ, CAPES, FAPESP)
52
Symposia- Abstracts
Symp#1 Prion protein in physiology and pathology
Chair Jerson Silva
Jerson Silva
Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil
Introductory notes
Neurodegeneration and Cancer: a Crosstalk Between Prion Protein and its Ligand STI1
Vilma R. Martins
Hospital A.C. Camargo, International Center for Research, Sao Paulo, Brazil
C
Prion protein (PrP ) is a highly abundant protein in the central nervous system. It’s misfolding is associated with fatal
C
neurodegenerative illnesses named prion diseases. PrP is known to bind to a number of extracellular or membrane
proteins triggering specific signals that modulate diverse cellular functions. One of these ligands is Stress Inducible protein
C
1 (STI1) whose interaction with PrP promotes neuronal survival, differentiation, neural progenitor/stem self-renewal and
C
memory formation. On the other hand, PrP transduces neurotoxic signals upon binding to A oligomers, the toxic
C
components in Alzheimer’s disease (AD). Our group has been exploring how the toxic signals triggered by PrP - A
oligomers can be impaired by STI1. The results point that at least in vitro the toxicity of A oligomers can be reverted by
C
C
recombinant STI1. Remarkable, PrP was described to participate in tumoral processes. Our results show that both PrP
and STI1 are highly expressed in human glioblastomas (GBM) and their expression is associated with increased tumor
C
proliferation and decreased patient’s survival. In cell culture of GBM and in animal models the inhibition of PrP -STI1
C
binding was able to inhibit the proliferation and also to increase animal survival. Therefore, the complex PrP -STI1 is an
important therapeutic target in AD and in GBM.
C
Neurotoxic Activities of PrP in Prion and Alzheimer’s Diseases
David A. Harris, Brian Fluharty, Jessie A. Turnbaugh, Tania Massignan, Ursula
Unterberger, and Emiliano Biasini
Dept. of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA
C
There is evidence that alterations in the normal physiological activity of PrP contribute to prion-induced neurotoxicity,
and may also play a role in Alzheimer’s disease. This mechanism has been difficult to investigate, however, because the
C
normal function of PrP has remained obscure, and there are no assays available to measure it. We have found that cells
expressing deletions or disease-associated point mutations in the conserved, central region of PrP exhibit spontaneous
ionic currents that are likely due to unconventional channels or pores formed by the mutant PrP molecules themselves.
These currents predispose neurons to excitotoxic death induced by endogenous, glutamatergic synaptic input. Current
activity depends on the presence of a polybasic amino acid segment at the N-terminus (residues 23-31) that may serve as
a tethered protein transduction domain capable of transiently permeabilizing the plasma membrane. The sequence
C
domains of PrP that are important for current activity are also critical for binding of oligomeric forms of the Alzheimer’s
C
Aβ peptide, suggesting that PrP may play a general role in mediating neurotoxicity in several neurodegenerative diseases,
perhaps via abnormal activity of ion channels.
53
Symp#2 Programs, Genes and Homeostasis
Chair José Xavier Neto
Ancient Programs of Gene Expression in Development and Homeostasis
José Xavier Neto
The origins of vertebrate cardiac chambers among the simpler peristaltic pumps of invertebrate chordates are not
understood. Peristaltic pumps operate by contractions that originate in the outside of a muscular conduit to squeeze its
contents inside. Although versatile and adaptable, peristaltic pumps are limited by poor inflow-to-outflow coordination,
often manifested by backflow, loss of fluid energy by distension, reflection and reversion. By breaking down circulatory
work into dedicated inflow (reservoirs or atria) and outflow modules (pumps or ventricles), chambered hearts eliminated
the inflow-to-outflow interference displayed by peristaltic pumps. This chambered mode of operation evolved only in
vertebrates and in mollusks, which are animals that display simple tubular peristaltic pumps during early phases of their
ontogenies, suggesting that chambered pumps evolved from ancestral peristaltic pumps. In amniotes such as mice and
chicken, cardiac progenitors are divided by differential RA signalling into two broad anterior and posterior domains that
will later give to outflow (ventricles and outflow tract) and inflow (sinus venosa and atria) cardiac tissues. This patterning
mechanism has been modeled in a two-step process. Early specification signals are first conveyed by paracrine diffusion of
the morphogen retinoic acid (RA) from posterior mesoderm towards posterior cardiac progenitors. Late determination
signals are communicated by autocrine RA signaling setup by a caudal to rostral wave of raldh2 (aldh1a2), a gene
encoding the main RA synthetic enzyme, which transiently confers posterior cardiac precursors with the ability to
synthesize their own RA.
Retinoic Acid Signaling in Development and Evolution
Michael Schubert
Institut de Génomique Fonctionnelle de Lyon (UMR 5242 du CNRS, Ecole Normale Supérieure de Lyon, Université Claude
Bernard Lyon 1), Université de Lyon, 46 allée d’Italie, 69364 Lyon Cedex 07, France.
E-mail: [email protected]
Extensive research carried out in the course of the last 100 years has established that retinoids, which constitute a group
of fat-soluble morphogens related to retinol (vitamin A), play crucial roles in early development, organogenesis, tissue
homeostasis, proliferation, differentiation, and apoptosis. In vertebrates, most, but not all, retinoid functions are
mediated by retinoic acid (RA) binding to heterodimers of two nuclear receptors: retinoic acid receptor (RAR) and retinoid
X receptor (RXR). Retinoid signaling was long thought to be vertebrate-specific, but developmental studies in invertebrate
chordates have revealed roles for retinoids conserved in all chordates. Outside chordates, however, evidence for
functional roles of retinoids and of the RAR/RXR heterodimer remains scarce, although recent bioinformatic analyses have
revealed that genes involved in retinoid signaling are present in the genomes of a variety of metazoan animals, including
echinoderms (sea urchins) and lophotrochozoans (annelids and mollusks). These in silico results suggest that the retinoid
pathway might have already been present in Urbilateria, the last common ancestor of protostomes and deuterostomes.
To obtain insights into the diversification of the retinoid signaling cascade during morphological and genomic evolution,
we have been using both developmental biology and bioinformatic approaches. We have thus addressed the question of
the evolutionary origins of the retinoid signaling pathway and studied the molecular hierarchy controlled by retinoid
signaling and its changes during evolution, with particular focus on the diversification of chordates. Altogether, our
analyses have provided new insights into the origin and functional elaboration of the retinoid signaling pathway in the
course of evolution.
Kleber Franchini
54
Symp#3 Gene Therapy
Chair Martin Bonamino
Gene Therapy of Limb Ischemia with GM-CSF
Sang Won Han
Department of Biophysics, Federal University of São Paulo, São Paulo, Brazil
Peripheral arterial diseases (PAD) affect about 1000 per million every year and about 200 of them suffer limb
amputations. The PAD incidence increases in the case of diabetic patients and people with more than 60 years. Therefore,
PAD has a high socio-economic and medical impact today. Approximately half of critical limb ischemic patients can be
treated by vascular surgery, but the remainder depends mainly on the velocity of adaptation of the existing collateral
vessels, a process known as arteriogenesis.
Several growth factors, cytokines and proteases are required for arteriogenesis, which is the process of remodeling preexistent vessels during the ischemia. The monocytes, attracted by the presence of tumor necrosis
factor-α and monocyte chemoattractant protein-1 at the inflammatory sites, are the main producers of factors for
arteriogenesis. The time and concentration of the factors required to complete arteriogenesis varies in each case of PAD,
consequently the action of the activated monocytes may not be enough to resolve the ischemic problem. One way to
prolong the life of monocytes is by inhibiting apoptosis by granulocyte-colony-stimulating factor (GM-CSF), which is a
hematopoietic-stimulator that enhances the survival, proliferation and rate of differentiation of hematopoietic cells.
In my presentation, therapeutic effects of GM-CSF in limb ischemia by gene therapy will be presented and discussed.
A Hematopoietic Stem Cell (HSC) Specific microRNA Gives Novel Insights into the Regulation of HSC Homeostasis and
Allows Safer HSC-based Gene Therapy
1,2
1,2
1
3
3
3
Bernhard Gentner , Alice Giustacchini , Ilaria Visigalli , Eric Lechman , Peter van Galen , Hidefumi Hiramatsu , Francesco
1,2
1
1,2
3
1
1,2
Boccalatte , Massimo Saini , Silvia Ungari , John E Dick , Alessandra Biffi and Luigi Naldini .
1
2
San Raffaele Telethon Institute for Gene Therapy; Vita-Salute San Raffaele University, San Raffaele Scientific Institute,
3
Milan, Italy; Division of Stem Cell and Developmental Biology, University of Toronto, Toronto, Ontario
We report that miR-126, a microRNA preferentially expressed in Hematopoietic Stem Cells (HSC) among the
hematopoietic lineage, plays a pivotal role in restraining cell cycle progression of HSC in vitro and in vivo. miR-126
knockdown expanded functional mouse and human HSC in vivo, without HSC exhaustion. Conversely, enforced miR-126
expression increased the fraction of phenotypic HSC in G0. miR-126 control of proliferation is attributable, in part, to
attenuation of signal transduction by the PI3K/AKT/GSK3β axis. We propose that miR-126 establishes a threshold for HSC
activation and provides negative feedback aiding the return of stimulated HSC to quiescence. Our results establish that
the HSC quiescence/activation equilibrium is regulated by miRNAs in a mechanism conserved between mouse and human.
The discovery of HSC-specific microRNAs also prompted us to design novel vectors for HSC-mediated gene therapy with
enhanced efficacy and safety. By adding miR-126 target sequences (miRT) to a vector cassette, miR-126 activity was
harnessed to negatively regulate transgene expression in HSC and target expression to differentiated hematopoietic cells.
These HSC-off vectors allow delivering a transgene into HSC without affecting its proteome, while achieving sustained
multi-lineage expression in the progeny. The utility of this new vector was demonstrated for the gene therapy of Krabbe
disease in the mouse model. miR-126 regulated vectors overcame hematopoietic toxicity associated to unregulated
galactocerebrosidase (GALC) expression in HSC, while delivering substantial amounts of GALC enzyme in the nervous
system with improved survival of the affected mice.
Conditional models for Chimeric Antigen Receptor (CAR) based activation of T lymphocytes
Martin Bonamino
Instituto Nacional de Cancer – Rio de Janeiro – Brazil
The modification of T lymphocytes with Chimeric Antigen Receptors (CARs) represents a promising strategy for combined
adoptive T cell based immune-gene therapy of cancer. Current CAR molecules are constructed fusing an immunoglobulinderived Fab-based antigen recognition domain in the scFv configuration, a transmembrane domain and signaling domains
promoting T cell activation. Clinical trials based on this strategy have reported impressive hematological responses for
leukemia and lymphomas for CARs designed against CD19, CD20 or CD30 antigens.
One potential limitation of this strategy is the off-target effects observed when target antigens are expressed in healthy
tissues. To circumvent this limitation we are considering conditional activation based on two CARs in a way that only the
correct antigen combination induces complete T cell activation. This strategy has the potential to expand the panel of
CAR-targeted antigens, narrowing T cell responses based on CAR mediated antigen recognition and increasing the safety
of CAR-based immune-gene therapies.
55
Symp#4 Cell Biology & Reproduction
Chair Luiz Renato França
Spermatogonial Stem Cell Niche in Vertebrates
Luiz R França
Luiz Renato França,Paulo HA Campos Júnior, Guilherme MJ Costa, Samyra SMSN Lacerda, Gleide F Avelar, Alana L Sousa,
*Marie-Claude Hofmann
Laboratory of Cellular Biology, Dept. of Morphology, ICB/UFMG, Belo Horizonte, MG, Brazil. *MD Anderson Cancer Center,
Dept. of Endocrine Neoplasia and Hormonal Disorders, Houston, TX, USA (email: [email protected])
Spermatogonial stem cells (SSCs) are located in a particular environment called the “niche” that is controlled by the
basement membrane, key testis somatic cells, and factors originating from the vascular network. Although crucial for SSC
physiology, the niche is still poorly understood, particularly in non-model vertebrates where the testis cytoarchitecture
+
could provide important cues for niche components and regulation. Recently, we demonstrated that Aund GFRA1 cells
present preferential location (nearby blood vessels) in vertebrate species other than mouse and rat, such as zebrafish,
bullfrog, turtle and horse. Additionally, we observed that peccaries present a peculiar Leydig cell (LC) distribution,
whereby these cells situate around lobes of seminiferous tubules. Since the role of LCs as a niche component is not yet
clearly elucidated, this feature makes the peccary an interesting model for investigating the SSC niche. Subsequently, we
+
observed that in peccaries, ~93% of Aundspermatogonia are GFRA1 and that these cells are preferentially located adjacent
to the interstitium without LCs. Moreover, the expression of CSF-1 was observed in LCs and peritubular myoid cells (PMCs)
+
while its receptor was present in LCs and in GFRA1 Aund. In summary, besides reinforcing the fundamental role of Sertoli
cells in GDNF-GFRA1 signaling for SSC self-renewal in vertebrates, our data suggest that the mechanisms involved in SSC
physiology may be conserved in vertebrates. However, our peccary findings indicate that, contrary to PMCs, LCs might
play a minor role in the SSC niche/physiology and that LCs are probably involved in the differentiation of Aund toward type
A1 spermatogonia.
Fetal Testis Differentiation and Function, its Regulation and its Disorders
Richard M Sharpe, Rod Mitchell, Afshan Dean, Karen Kilcoyne, Sophie Platts, Ashley Boyle, Sheila Macpherson, Chris
McKinnell, Richard Anderson, Sander van den Driesche
MRC Centre for Reproductive Health, The Queen’s Medical Research Institute, University of Edinburgh, UK (contact:
[email protected])
Differentiation of the testis represents the first step along the pathway to becoming a male. Understanding of the
processes that regulate testis differentiation have added importance because there is increasing evidence that the
commonest disorders of human male reproductive health may largely stem form this period in life. Thus the testicular
dysgenesis syndrome (TDS) hypothesis proposes that subnormal ‘set-up’ of the fetal testis/cell types leads to subnormal
function (especially of the fetal Leydig cells) which, in turn, leads to male reproductive disorders that manifest at birth
(cryptorchidism, hypospadias, micropenis) or in adulthood (low sperm count, low-normal testosterone, testis germ cell
cancer). Direct evaluation of this hypothesis in humans is difficult, so we have used a rat model of TDS (fetal exposure to
dibutyl phthalate; DBP) to help elucidate key mechanisms and cell-cell relationships in the fetal testis, disruption of which
leads to TDS disorders. These have helped identify the masculinisation programming window (MPW) within which
testosterone production by fetal Leydig cells is critical for determining normality and ultimate adult size of all male
reproductive organs; deficiency in testosterone production in the MPW determines risk of later TDS disorders and can be
‘measured’ retrospectively by anogenital distance (AGD). Our studies show that DBP-induced focal dysgenesis
(malformation of seminiferous cords, intratubular Leydig cells, mis-specification of somatic cells) is closely interlinked with
deficiency in testosterone production in the MPW, even though the dysgenesis manifests after the MPW. The mechanisms
and factors involved, insofar as they are understood, will be discussed.
Antimicrobial Proteins Secreted by the Epididymis
Maria Christina W. Avellar
Section of Experimental Endocrinology, Department of Pharmacology, Universidade Federal de São Paulo – Escola Paulista
de Medicina (UNIFESP-EPM), São Paulo, SP, 04044-020, Brazil.
This presentation will focus on the expression and regulation of naturally occurring antimicrobial proteins secreted by the
epididymis. Aspects of the pattern of expression of mRNA and protein for selected genes, highlighting isoforms expressed
by the beta-defensin SPAG11B gene, in the adult tissue and during development of the rat epididymis will be discussed.
The effects of androgens, luminal fluid, glucocorticoids and exposure to in vivo bacterial products on their expression and
immunolocalization will be also presented. Financial Support: FAPESP, CNPq, CAPES and Fogarty International Center
(subcontract UNIFESP-EPM/University of North Carolina at Chapel Hill, USA). Email: [email protected].
56
Symp#5 Host Parasite Interaction
Chair Wanderley de Souza
Wanderley de Souza
Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil
Introductory Notes
Dephosphorylation of eIF5A is Required for Translation Arrest at the Stationary Growth Phase of Trypanosoma cruzi
Chung, J.*; Rocha, A. A.*, Tonelli, R. R.;,Castilho, B. A., and Sérgio Schenkman.
Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de São Paulo, São Paulo, Brazil
* Both authors contributed equally
The protein known as eukaryotic initiation factor 5A (eIF5A) has an elusive role in the translation elongation. It has a unique and
essential hypusine modification on a conserved lysine residue in most eukaryotes. In addition, this protein is modified by
phosphorylations with unknown functions. Here we found that a phosphorylated state of eIF5A from Trypanosoma cruzi (TceIF5A),
the protozoan that causes Chagas’ disease, predominates in exponentially growing cells and extensive dephosphorylation occurs in
cells reaching the stationary growth phase. The phosphorylation was shown to occur mainly at Ser 2, then at Ser 47, homologous to
yeast eIF5A. In addition, a novel phosphorylation site was identified at Tyr 21. In exponential cells, TceIF5A is partially associated with
polysomes, compatible with its function as an elongation factor and become relatively enriched in polysomal fractions at stationary at
stationary phase. TceIF5A overexpression increases the rate of cell proliferation, protein synthesis, and the relative amount of
polysomes. When Ser 2 is replaced by Asp, but not by Ala, in the overexpressors, the cells still show an increased protein synthesis
and growth rate. However, the presence of Asp causes cell damage when cultures reach the stationary phase. Wild type, or Ala, but
not Asp replacing Ser 2 forms of TceIF5A causes protein synthesis arrest and are enriched in polysomal content at the stationary
phase. We conclude that dephosphorylation of eIF5A has a key role in arresting the protein synthesis under unfavorable conditions,
indicating that eIF5A phosphorylation/dephosphorylation might control its association with polysomes during translation elongation.
Ion Regulation in the Malaria Parasite: The Target of a New Generation of Antimalarials
Kiaran Kirk
Research School of Biology, The Australian National University, Canberra, ACT, 0200, Australia
The intraerythrocytic malaria parasite induces novel channels in the membrane of its host erythrocyte. These channels mediate the
uptake of essential nutrients but, at the same time, allow a net influx of Na+ ions, resulting in an elevated Na+ concentration in the
host cell compartment. The intraerythrocytic malaria parasite itself maintains an intracellular Na+ concentration some ten-fold less
than that in its host cell, extruding Na+ via a Na+-ATPase on its plasma membrane. Bioinformatic analysis of the genome of the human
malaria parasite Plasmodium falciparum reveals that the most likely candidate for the parasite’s Na+ ATPase is a protein known as
PfATP4.
The spiroindolones are a new class of compound that inhibit the in vitro growth of the human malaria parasite, Plasmodium
falciparum, at nanomolar concentrations. One of the spiroindolones is now in Phase IIa clinical trials, and is the first molecule with a
novel mechanism of action to enter Phase IIa studies for malaria in the last 20 years. Prolonged exposure of P. falciparum parasites to
sub-lethal concentrations of spiroindolones leads to the emergence of spiroindolone-resistant parasites, with the resistance
attributable to mutations in PfATP4. In this talk I will introduce the cell physiology of the intracellular malaria parasite and present
evidence that the spiroindolones exert their antimalarial effect by inhibiting Na+ extrusion via PfATP4, thereby disrupting Na+
regulation in the intracellular parasite.
Why coinfect cells with non-viral pathogens?
Michel Rabinovitch
Universidade Federal de São Paulo – Escola Paulista de Medicina, Departamento de Microbiologia, Imunologia e Parasitologia, São
Paulo, Brazil e-mail: [email protected]
Coinfection of E. coli bacteria with mutant bacteriophages in the 1940s spurred the development of molecular virology. Beginning in
the 1960s, virologists, among them alumni of the CSHL Phage Course, coinfected mammalian cells with virus mutants, strains or
species and developed the basic procedures and concepts of viral genetics. The AIDS pandemic of the 1980s begot cell coinfections of
HIV and non-viral pathogens. In the 1990s, impressive horizontal gene exchanges were detected between pathogens sheltered in
free-living protozoa. In contrast, there are few reports–briefly reviewed in the presentation-of mammalian cells coinfected with
bacteria or protozoa. Initially, the model permitted the targeting of pathogens to intracellular compartments they normally don’t
occupy, thanks to C. burnetii’s exceptionally large and hospitable parasitophorous vacuoles. Vacuolar colocalization will probably be
rare in the world of coinfections. We believe that coinfection, apart from its ludic quality, may uncover unexpected, and hopefully
interesting, interactions involving (for instance), antagonism via secreted toxins or antibiotics, competition for cell derived nutrients,
quorum sensing effects, exploitable modulation of host cell gene expression and transduction cascades. We thus argue that
coinfection with non-viral-pathogens could provide an added tool for mono-infection-entrenched cellular microbiologists. However,
whereas mono-infections may reflect a dialogue – by proxy - between two genomes, the neo-coinfector may be confronted with a
livelier dialogue involving three – genomes, besides the potential participation of a fourth, the host cell mitochondrial genome. One
problem remains: given the number of available microorganisms, how is one to select the most promising pair for coinfection?
57
Symp#6 Membrane Biology
Chair José Garcia Abreu
New Inhibitory Wnt/β-catenin Mechanisms Affecting Embryonic Head Formation
Jose Garcia Abreu, PhD.
Instituto de Ciencias Biomédicas – Universidade Federal do Rio Janeiro. Rio de Janeiro – Brazil.
The establishment of vertebrate embryonic axes involves a series of cellular and molecular events right after
fertilization. In the frog embryo the dorsal ventral axis relies on accumulation of dorsal beta-catenin which together
with Nieuwkoop center set the dorsal organizer, also known as Spemann Organizer. Upon the onset of gastrulation a
number of secreted factors act dorsally preventing dorsal fate from ventral signals. At the same time cells from the
prechordal plate endomesoderm secrete inhibitors of ventro-lateral Wnt signals setting up the antero-posterior axis.
Therefore, Wnt/beta-catenin signaling plays major role in the establishment and patterning of embryonic axis. Here,
we present a new Wnt-beta-catenin inhibitor, expressed in the Spemann Organizer which is essential for proper head
formation. We also present data on how cholestero-rich membrane microdomains interfere with the morphogentic
fields in the head organizer, the pre-chordal plate.
Support: FAPERJ, CNPQ and CAPES.
Membrane Dynamics and Mechanics of Signaling: Role of Caveolae
Sinha, B., D. Koster, R. Ruez, P. Gonnord, M. Bastiani, D. Abankwa, R.V. Stan, G. Butler-Browne, B. Vedie, L. Johannes,
N. Morone, R.G. Parton, G. Raposo, P. Sens, C. Lamaze, and P. Nassoy. 2011. Cells respond to mechanical stress by
rapid disassembly of caveolae. Cell. 144:402-13.
Nassoy, P., and Christophe Lamaze. Stressing caveolae new role in cell mechanics. Trends Cell Biol. in press
Institut Curie, Paris, France
The functions of caveolae, the characteristic plasma membrane invaginations, has long remained debated. The
particular abundance of caveolae in endothelial and muscle cells cells, which respectively experience shear stress and
stretching, led us to investigate the role of caveolae in membrane-mediated mechanical response. Acute mechanical
stress induced by osmotic swelling or by uniaxial stretching results in a rapid disappearance of caveolae, in a reduced
caveolin/Cavin1 interaction, and in an increase of free caveolins at the plasma membrane. Tether-pulling force
measurements in cells and in plasma membrane spheres demonstrate that caveola flattening and disassembly is the
primary actin- and ATP-independent cell response that buffers membrane tension surges during mechanical stress.
Conversely, stress release leads to complete caveola reassembly in an actin- and ATP-dependent process. We further
show that mechanosensing through caveolae in endothelial cells involves the Jak/Stat signaling pathway. Caveolae are
therefore mechanosensors and mechanotransducers which constitute a physiological membrane reservoir that quickly
accommodates sudden and acute mechanical stresses.
Studying Spatial Control of Exocytosis at the Nanoscale in Living Cells
Derek Toomre
Yale University School of Medicine, USA
Cells spatially control exocytosis to control a range of biological function – from cell division, migration, invasion and
the formation of specialized structures such as the primary cilium. Loss of this spatial-temporal control can lead to
diseases including cancer, diabetes, and polycystic kidney disease. This seminar will focus firstly on new superresolution ‘nanoscopes’ and their power to visualize subcellular processes with incredible detail. I will then show how
it to query and even optogenetically manipulate the very last steps of exocystosis, vesicle tethering and fusion. As case
studies, I will show how this approach has given new insight and lead to new concept in cytokinesis, cell migration, and
insulin-mediated trafficking of Glut4 in adipocytes. For examples, in adipocytes we see two membrane trafficking
pathways to the surface and a regulation by insulin on the expansion of the fusion pore. Challenges and potentials of
these new nanoscopes, with special emphasis to membrane traffic, will be discussed.
58
Symp#7 Signaling in development
Chair Ricardo Guelerman Pinheiro Ramos
Ricardo Guelerman Pinheiro Ramos
University of São Paulo, Ribeirão Preto, Brazil
Introductory notes
Wnt Signaling, Stem Cells and Tissue Repair
Roel Nusse, Howard Hughes Medical Institute, Department of Developmental Biology, Lorry I. Lokey Stem Cell
Research Building. Stanford
Work from many laboratories has shown that Wnt signals are essential for the control over stem cells. A right balance
between the number of stem and differentiated cells is essential for the proper function of organs. Locally acting
signals, including Wnts, are important to maintain this balance in a spatially organized manner and these signals are
key to understanding the regulation of growth. How this is achieved is far from clear and is the subject of studies in our
lab, both in vivo and in cell culture. In vivo, a particular question we address is how physiological changes, such as
those occurring during hormonal stimuli, injury or programmed tissue degeneration have an impact on the selfrenewal signals and on stem cell biology. Current research includes: 1) Identifying and tracing Wnt-responsive stem
cells in tissues; 2) mapping cis-acting transcriptional control elements (enhancers) that control Wnt gene expression in
normal and injured tissues; 3) the use of active Wnt proteins to maintain stem cells (including embryonic stem cells) in
cell culture; 4) presenting Wnt protein in a vectorial manner to stem cells to direct asymmetric cell division.
Formation of the Vertebrate Body Axis
Olivier Pourquié
Institut de genétique et biologie moleculaire et celulaire, INSERM, France
Hedgehog Signaling in Development and Disease
Matthew Scott
Departments of Developmental Biology, Genetics, and Bioengineering, Howard Hughes Medical Institute, Clark Center
West Wing W252, 318 Campus Drive, Stanford University School of Medicine, Stanford, California 94305-5439
Phone 650-725-7680 Fax (650) 725-2952
Hedgehog (Hh) signaling is important for the development of most organs and tissues. Damage to Hh signal
transduction components causes birth defects and cancer. We have been exploring four areas of Hedgehog signaling:
transduction in primary cilia, roles of Neuropilin proteins, identification of direct Hh target genes in the cerebellum and
medulloblastomas (MBs), and mutations in MB tumor genomes. Neuropilins 1 and 2 (Nrp1, 2) are transmembrane
proteins with roles in axon guidance and vascular endothelial growth factor (VEGF) signaling. We found that they are
important positive regulators of Hh signal transduction. Nrps are expressed at times and locations of active Hh signal
transduction during mouse development. We show that Nrps mediate Hh transduction between activated
Smoothened (Smo) protein and the negative regulator Suppressor of Fused (SuFu). Nrp1 transcription is induced by
Hh signaling and Nrp1 over-expression increases maximal Hh target gene activation, indicating the existence of a
positive feedback circuit. We are testing the importance of Nrps for growth of MB cells. Nrps act upstream of Gli
proteins, transcription factors that directly control Hh target gene transcription. We have identified direct targets of
Gli1 in normal mouse cerebellum development and in MBs, and found that Gli1 is located at some common genes in
the two cell types as well as many locations unique to each cell type. To understand better the properties of MB
tumor cells we are determining exome sequences of human and mouse tumors.
59
Symp#8 Epithelial proliferation and differentiation
Chair Mari Sogayar
Mari Sogayar
Department of Biochemistry, Chemistry Institute, University of São Paulo, São Paulo, Brazil
Introductory notes and talk
Intrinsic And Extrinsic Regulation Of Epidermal Stem Cell Fate
Fiona M Watt
CRUK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
When an epidermal stem cell divides its progeny can either remain stem cells or undergo terminal differentiation.
These cell fate decisions are controlled both by intrinsic mechanisms and by external signals from the local
microenvironment or niche. Interactions between epidermal stem cells and the niche are reciprocal, since stem cells
are capable of remodelling their environment. My lab is investigating the interplay between specific intrinsic and
extrinsic signals in regulating stem cell fate in adult epidermis. We find that both in vitro and in vivo approaches are
informative and conclude that the way that a stem cell behaves is to a large extent determined by extrinsic signals.
Wellcome Trust Centre for Stem Cell Research , University of Cambridge (CSCR), and the other in Cancer Research UK
Cambridge Research Institute (CRI)
Differential roles for NFAT transcription factor isoforms in cell transformation
João Viola
Program of Cellular Biology, Instituto Nacional de Câncer (INCA), Rio de Janeiro, RJ, Brazil.
The nuclear factor of activated T cells (NFAT) family of transcription factors are inducible proteins that play a key role
in gene expression. The NFAT family is composed of four calcium-responsive proteins (NFAT1-4). Each NFAT gene may
be alternatively spliced into two or more isoforms that differ at the N- and/or C-termini, although the core of the DBD
and NHR regions remain conserved. Once NFAT is activated, these proteins can bind to their target promoter elements
and activate the transcription of specific responsive genes, either alone or in combination with other nuclear partners.
Regardless of their widely known cytokine gene expression properties, NFAT transcription factors have been shown to
regulate other genes related to cell cycle progression, cell differentiation and apoptosis, unraveling a broader role for
these proteins in normal cell physiology. Recent studies suggest that the NFAT family of transcription factors plays a
much broader role in cell proliferation and apoptosis, and their contributions to tumorigenesis are becoming clearer.
Here, we demonstrate that three of NFAT proteins (NFAT1 and NFAT2 - and -isoforms) induce distinct phenotypes
in NIH3T3 cells and the differential roles for NFAT family members are partially mapped to the transactivation domains
(TAD) located at the N- and C-terminal end of these proteins. In fact, our results suggest that NFAT1 and NFAT2 isoform act as tumor suppressor genes, mainly by inducing cell death and cell cycle arrest, whereas NFAT2 -isoform
act as an oncogene, by protecting cells from apoptosis. Finally, our results support distinct roles for the different
isoforms of NFAT transcription factors in cell transformation.
Financial Support: ICGEB, INCT-Cancer, FAPERJ, CNPq and CAPES.
Contact: [email protected]
60
Symp#9 Immune Cell Biology
Chair Wilson Savino
Wilson Savino
Introductory notes and talk
Immunological and Clinical Outcomes of a New DC-Based Vaccine
Flavio Salazar-Onfray and Mercedes López
1
Millennium Nucleus on Immunology and Immunotherapy, Faculty of Medicine, University of Chile.
We developed an original method for production of therapeutic dendritic-like cells named Tumor Antigen Presenting
®
Cells (TAPCells ) using an allogeneic melanoma-derived cell lysate (TRIMEL) as activation factor and antigen provider.
TAPCells-based immunotherapy induced T cell-mediated immune responses and improved long-term survival of stage
IV patients in studies involving more than 100 individuals (López et al. 2009, J Clin Oncol; Aguilera et al. 2011, Clin
Cancer Res). Importantly, 61% of tested patients (58 out of 94) showed a Delayed Type Hypersensitivity (DTH) reaction
against TRIMEL indicating the development of anti-tumor immunological memory that correlates with prolonged
patient survival. The in vitro analysis of TRIMEL showed that it contains damage associated molecular patterns such as
HMBG-1 protein, induced by heat shock, capable to improve, through TLR4, the DC maturation and antigen crosspresentation. In fact, a TLR4 polymorphism correlates with patient clinical outcome. DTH response against TRIMEL was
associated with prolonged survival of the stage IV responder melanoma patients (DTH +; 35 months) compared to the
non-responders (DTH -; 11 months). Furthermore, we observed that DC-vaccination resulted in a three-fold augment
of Th1 cell population releasing IFN-γ and a two-fold increase of Th17 lymphocyte population capable to produce IL-17
in the PBL of DTH+ patients respect to DTH- ones. Antibodies against melanoma antigens can be detected in the sera
from several vaccinated patients, althougth no correlation with clinical responses could be established. Taken
together, our results indicate that TAPCells immunization resulted in two different pattern of response associated to
the immunological and clinical outcome. Our study may contribute to the better understanding of clinical
immunological responses produced by DC-vaccines and to the development of improved DC-based vaccines.
Supported by Fondecyt 1090238 and 1090243.
Eph/ephrin-mediated Interactions Govern Functional Maturation of Developing Thymocytes in the Thymic Epitelial
3D Network
1
2
1
1
2
1
Agustín G Zapata , Juan J Muñoz , David Alfaro , Javier Gª Ceca , Teresa Cejalvo , Esther Trobajas , Sara Montero
(1) Department of Cell Biology, Faculty of Biology, (2) Centre for Cytometry and Fluorescence Microscopy,
Complutense University, 28040 Madrid, Spain
1
The thymus is a primary lymphoid organ in which a 3D epithelial network supports the functional maturation of
lymphoid progenitors into T lymphocytes. The process is highly dependent on the migration of developing thymocytes
to the adequate thymic niche in which thymic epithelial cell (TEC)-thymocyte interactions are critical. In the current
presentation we report the role played in these processes by Eph and ephrins, a large family of receptors and ligands,
respectively involved in the organogenenesis and homeostasis of numerous tisssues, regulating cellular
attachment/detachment. They are extensively expressed in the thymus, partially govern colonization of lymphoid
progenitors and their migration throughout thymic parenchyma and their lack deeply affects not only T-cell maturation
but also correct organization of thymic epithelial network, reflecting the relevance of these molecules in the
thymocyte-TEC interactions that largely modulate the biology of thymus
61
Symp#10 Cell Biology and Education
ASCB & IFCB Symposium
Chairs Bruce Alberts and Cynthia Jensen
Cell Biology and Education
Jensen, C.G.
Department of Anatomy with Radiology
University of Auckland, Auckland, New Zealand
Although Cell Biologists have a wide range of research interests, they all have a common interest in teaching cell and
molecular biology to undergraduate and postgraduate students and in training masters and PhD students and
postdoctoral fellows in research techniques. The speakers and discussants at this symposium will describe a variety of
methods of teaching and training in cell biology, including descriptions of special courses and distance teaching. There
will be an opportunity for discussion, and questions and comments from the audience will be encouraged.
Teaching at Distance: Interactive Multimedia of the Cell Biology of Trypanosoma cruzi
1, 2
2
1,4
3, 4
Benchimol, M. , Teixeira, D.E. , Crepaldi, P.H. ; De Souza, W.
1
Universidade Santa Úrsula, Rio de Janeiro, RJ, Brasil
2
Fundação CECIERJ, Rio de Janeiro, RJ, Brasil.
3
Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Brasil
4
INMETRO, Rio de Janeiro, RJ, Brasil
CECIERJ is a state public foundation focused in education. It includes the CEDERJ arm, which is specialized in teaching
at distance as university. Our group has developed an intense work producing multimedia material to undergraduate
students in Biology. The aim of this work was to develop educational materials in the graphical version using threedimensional (3D) animations, to visualize the morphology, dynamic processes and basic knowledge of the Cell Biology
as a whole and here, in special of Trypanosoma cruzi, the causative agent of Chagas´ disease. Parasitic protozoa are
important agents of human and veterinary diseases not only in Brazil but also all over the world. The life cycle of these
protozoa is presented in different levels of education, from fundamental school to graduation level. Videos and
animations include: cell division, endocytosis and flagellar beating; the interaction of the parasite with a vertebrate
host cell and the behavior of this protozoan in the digestive tract of the invertebrate host. Thus, this material could: (1)
facilitate the cell biology of parasites learning and teaching, (2) provide good material which can be used by several
people at different levels, such as lectures, classes, research, thesis, etc.
Supported by CNPq, FAPERJ and CECIERJ
Engaging Undergraduate Students in Research
Kiaran Kirk
Research School of Biology, The Australian National University, Canberra, ACT, 0200, Australia
There are many benefits to be gained from engaging high-achieving students in ‘real research’ from as early as possible
in their undergraduate career. At the Australian National University we offer students the opportunity to do
laboratory-based ‘Biology Research Projects’ that count as courses towards their Science degree. We have also
introduced a research-focused (and highly-selected) degree, the ‘Bachelor of Philosophy’, in which a quarter of the
courses taken over a three year period are in the form of research projects. Our experience with this mode of teaching
will be discussed.
62
Symp#11 Glia Club
Chairs Bernardo Castellano and Vivaldo Moura Neto
GSK3β is a Profound Negative Regulator of Oligodendrocyte Differentiation and Myelination
Arthur M. Butt, Andrea Rivera and Kasum Azim
Institute of Biomedical and Biomolecular Sciences, University of Portsmouth, U.K.
Oligodendrocytes are the myelinating cells of the central nervous system and are the primary targets of tissue destruction in the
demyelinating disease multiple sclerosis. The enzyme GSK3β is a target of many receptor-mediated signalling pathways that regulate the
differentiation of from their precursors (OPCs). We have examined this using a range of small molecular inhibitors of GSK3β in the mouse
brain. Inhibition of GSK3β stimulates the generation of OPCs from neural precursor cells (NPCs) in the subventricular zone (SVZ), involving the
canonical Wnt-β-catenin signalling pathway. Significantly, inhibition of GSK3β also dramatically stimulates oligodendrocyte differentiation and
myelination. A key finding is that GSK3β inhibition has equivalent effects in the adult and stimulates the regeneration of oligodendrocytes and
remyelination following demyelination in the adult forebrain. Using a genome wide microarray approach, we find that GSK3β inhibition
regulates oligodendrocyte generation via multiple positive and negative regulatory signalling pathways. GSK3β inhibition significantly upregulated Sox10 and Olig2, key positive regulators of oligodendrocyte differentiation, and down-regulated the Wnt and Notch signalling
pathways, together with helix-loop-helix ID (inhibitor of differentiation), which are dominant negative regulators of oligodendrocyte
differentiation. This study identifies novel functions for GSK3β as a profound negative regulator of oligodendrocytes at all stages of their
differentiation in vivo. Moreover, our findings indicated that GSK3β signalling pathways contributed to inefficient regeneration of
oligodendrocytes and myelin repair in demyelination.
Role of Cancer Stem Cells in Adult and Paediatric Brain Neoplasms: Hoax or Holy Grail?
Professor Geoffrey J Pilkington BSc PhD CBiol FSB FRCPath
Professor of Cellular and Molecular Neuro-oncology, University of Portsmouth, St Michael’s Building, White Swan Road Portsmouth PO1 2DT
UK
In the 1970s stem cell-like populations were described in ethylnitrosourea-induced rat glioma and hypothesised as the origin of such tumours.
These were located around blood vessels and degenerating neurones, sub-ependymally, at the lateral ventricles. More recently cancer stem
cells (CSCs), reported largely on their expression of CD133, gathered considerable interest in adult and paediatric brain tumours. Initial
observations that the CD133+ population were the initiators of brain tumours, based upon their ability to produce tumours in xenograft
models while CD133- failed to do so have, however, been challenged. The value of CD133 (Prominin-1) has therefore been questioned but the
function of CD133 or its possible link with processes underlying tumour development and progression remains obscure. Adult glioblastoma
biopsies yield only 1-5% CSCs based upon CD133 immunostaining. We described a low passage paediatric glioblastoma culture where over
40% of the cells express CD133 and, if transferred to neural basal medium under hypoxic conditions, this elevated to >95% CD133+. Magnetic
bead immunoseparated CD133+ and CD133- were used for genetic profiling, adhesion, invasion, and proliferation assays in response to
nuclear- and mitochondrially-acting pro-apoptotic agents. We also investigated the significance of CD133 glycosylation and influence of oxygen
on such glycosylation. Whether or not CD133 is a marker of CSCs in brain tumours remains controversial but it may be of significance to the
biology of paediatric brain neoplasms and requires further investigation both in vitro and in tissue sections. Hoax? certainly not, but CD133
must be put into context and, while the Holy Grail issue remains unresolved, this is an area of intense interest in unravelling the mysteries of
tumour biology.
Mesenchymal Stem Cells lower proliferation and invasion of Glioblastoma cells, exploiting the Immune Response Mediating Chemokines
Tamara T. Lah, Motaln H1 , Gruden K2, Hren M2, Primon M1 and Schichor Ch3
1.
Department of Genetic Toxicology and Cancer Biology, National Institute of Biology, Ljubljana, Slovenia. 2 Department of Biotechnology and
Systems Biology, National Institute of Biology, Ljubljana, Slovenia. 3 Klinikum Großhadern, Ludwig-Maximilians-Universität, München,
Germany.
Human mesenchymal stem cells (hMSC) are gaining the forefront position in therapies for curing several diseases. The majority of them is
focused on the improvements in the regenerative medicine, whereas only limited number of studies is addressing the potential use of hMSC
for anti-cancer therapy, although the findings in several different cancer models are suggesting they could be developed into efficient cellbased therapeutics.
Considering recent in vivo and in vitro reports on hMSCs growth inhibitory effect on most malignant brain tumor – glioblastoma multiforme
(GBM) we focused here on the cellular processes responsible for this inhibitory effect, such as cell proliferation, invasion and senescence
which we confirmed in several GBM lines. We performed whole genome mRNA analysis and cytokine profiling of both, the hMSC and the U87MG GBM cells grown in co-cultures. We found that several chemokines may account either for the decrease of both, proliferation and invasion
of U87-MG, as well as for induced MSCs proliferation and invasion when the two cells were grown in the indirect co-cultures. CCL2/MCP-1 was
collectively identified as one of the few most significantly up-regulated chemokine responsible for hMSC and U87-MG paracrine signaling and
we functionally confirmed its role in GBM cell invasion in vitro.
In conclusion, our results indicate the CCL2/MCP1 to be the key player of paracrine MSC/glioma cell interactions. Several other gene/protein
putative markers were identified to take part in hMSC/glioma cell communication for the first time. Together with CCL2/MCP-1 those markers
could be utilized in future, as target genes for cell-based anticancer therapy.
Effects of cns-targeted il-6 or il-10 production on microglial activation and motor neuron degeneration after facial nerve
axotomy
B. Castellano1, N. Villacampa1, B. Almolda1, I.L. Campbell2 and B. González1
1Department of Cell Biology, Physiology and Immunology, Institute of Neurosciences. Universitat Autònoma de Barcelona, Spain. 2School of
Molecular Bioscience, University of Sydney, Sydney, NSW 2006, Australia
Interleukin-6 (IL-6) and Interleukin-10 (IL-10) are key cytokines with an important role in the regulation of the inflammatory and immune
responses. In the central nervous system (CNS), increased expression of both IL-6 and IL-10 occurs in a wide range of pathological conditions.
Meanwhile IL-6 has been usually recognized as a cytokine with a dual role acting as a pro-inflammatory or anti-inflammatory signal inducing glial
activation while IL-10 is mainly involved counteracting the inflammatory response and immune reactions. The objective of the present study was
to evaluate the effects of local production of either IL-6 or IL-10 in the microglial response, lymphocyte infiltration and neuronal degeneration
induced by transection of the facial nerve, a sterile neuronal injury model. Facial nerve axotomy (FNA) was performed in transgenic mice with
astrocyte-targeted production of either IL-6 (GFAP-IL6Tg) or IL-10 (GFAP-IL10Tg) and their corresponding wild-type (WT) littermates. The
analysis was performed by histology, immunohistochemistry and flow cytometry at different time points, ranging from 3 to 42 days post-lesion.
Our observations clearly indicate that GFAP targeted expression of either IL-6 or IL-10 exerts a direct impact on the pattern of microglial
activation and neuronal degeneration/survival or axotomized motor neurons. As will be discussed, changes observed in the expression of
different molecules such as Iba1, CD11b, CD16/32, MHC class II and some integrins like osteopontin and their receptors (CD44 and 5) may be
involved in the differential glial activation pattern and lymphocyte recruitment producing a specific outcome of facial nerve axotomy.
Supportedby Ministerio de Ciencia e Innovación (BFU2008-04407/BFI) (BFU2011-27400) and NH&MRC grant 632754
63
Symp#12 Protein Folding and Assembly
Chair Carlos Ramos
Protein Folding and Assembly
Carlos Ramos
Chemistry Institute, UNICAMP, Campinas, Brazil
Protein folding and assembly have strong biotechnological and medical relevance, and understanding how proteins fold into their
native structures has long been a major goal for researchers aiming to predict structure from the primary amino acid sequence.
Protein homeostasis is relevant for several cellular processes, such as aging, neurodegenerative diseases, evolutionary processes, and
synaptic plasticity. Although failure to reach or maintain the correct folded structure leads to serious consequences, under normal
circumstances aberrant proteins become eliminated. A correct balance between folding and the degradation of misfolded proteins is
maintained by a basic cellular phenomenon known as protein quality control (PQC). This correct balance is critical for cell viability,
particularly when considering macromolecular crowding in the intracellular environment. In this environment, improper associations
between partially unfolded proteins are enhanced, and mechanisms that prevent incorrect folding or help to eliminate irreversible
aggregates that may be harmful to cells are necessary. The resulting misfolded proteins may be degraded by proteases or repaired by
chaperones, but proteins that escape PQC will probably aggregate. In this symposium speakers will discuss recent advances in our
knowledge of how proteins fold and assembly inside the cell.
Mechanisms for folding corrector action in rescue of mutant CFTR from premature degradation by ER Quality Control
Douglas M. Cyr
Department of Cell Biology, School of Medicine, UNC-Chapel Hill, Chapel Hill, NC, 27599
CF patients inherit a variety of mutations that cause folding defects in CFTR, which lead to its recognition for premature degradation
by Hsp70 dependent E3 ubiquitin ligases (RMA1 and CHIP) on the cytoplasmic face of the ER. The folding defects in ΔF508-CFTR, as
well as defects in other rare mutants, are correctable, but the mechanism of action for folding correctors is unknown. ΔF508 occurs
in nucleotide binding domain 1 (NBD1) and blocks Cl- channel assembly by hindering interactions of NBD1 with intracellular loops
exposed by MSD1 and MSD2. Therefore, correction of folding defects in ΔF508-CFTR requires assembly to a conformation to permits
escape form multiple ERQC machines and may require repair of more than one folding defect. This talk we describe current
knowledge about the mechanism for recognition of misfolded CFTR by ERQC machines and present information on the mechanism
for folding corrector action in treatment of CF. Prospects for treatment ΔF508 homozytotes and compound heterozygotes with
different combinations of folding correctors will be discussed.
This work is supported by grants from the National Institutes of Health and the North American Cystic Fibrosis Foundation.
Chaperonopathies: Impact on protein folding and beyond
Alberto J. L. Macario, a,b and Everly Conway de Macarioa
a
Department of Microbiology and Immunology, School of Medicine, University of Maryland at Baltimore, and IMET, Baltimore, MD,
USA; bIstituto Euro-Mediterraneo di Scienza et Tecnologia (IEMEST), Palermo, Italy.
Chaperonology encompasses the study of molecular chaperones and heat-shock proteins in all their aspects, normal and abnormal;
physiological and pathological, including medico-clinical; biochemical; molecular biological; genetic; and biological. A subfield of
Chaperonology deals with the chaperonopathies, i.e., diseases in which chaperones play a pathogenic role, participating in the
mechanism of disease as etiologic-pathogenic factors. These diseases can be classified as any other in the Medical textbooks,
considering genetic features, molecular mechanism, age of onset, clinical manifestations and course, response to treatment, and so
on. Some are genetic and hereditary while others are acquired and not transmissible, the former are due, for example, to mutations
in a chaperone gene, whereas the latter are due, for example, to post-translational modifications of the chaperone protein molecule.
Since this is a new field, only recently defined within Medicine and that is not treated in most textbooks of Medicine or Pathology, the
presentation will consist of an introductory overview. Various types of genetic and acquired chaperonopathies will be briefly
discussed, considering that malfunctioning chaperones affect not only protein homeostasis (i.e., the canonical role of chaperones) but
alto other unrelated cellular functions, pertaining for example, to cancer and autoimmune diseases. Some of these are classified as
chaperonopathies by mistake or collaborationism. In them, one or more molecular chaperone, even if normal, actively favors disease,
e.g., certain types of cancer require chaperones for cell growth and dissemination; in this context, data on Hsp60 chaperone
migrations in cancer will be described. Acknowledgment: AJLM was partially supported by IEMEST. e-mail:
[email protected]
REDOX PROCESSES ASSOCIATED WITH PHYSIOLOGICAL PROTEIN FOLDING AND ENDOPLASMIC RETICULUM STRESS
Francisco R. M. Laurindo
Vascular Biology Laboratory, Heart Institute(Incor), University of São Paulo School of Medicine.
Protein folding at the endoplasmic reticulum(ER) lumen involves chaperone-assisted folding, glycosylation and disulfide bond introduction, the later
consisting in the transfer of oxidizing equivalents to cysteine thiols at their correct location in nascent proteins. The main effectors of disulfide bond
introduction are protein disulfide isomerase(s), particularly PDIA1 (PDI). ER-based PDI is an abundantly expressed thioredoxin superfamily
oxidoreductase displaying many interactions with redox and nonredox proteins and several post-translational modifications. PDI family contains >20
members with some apparent complementary actions. PDI has oxidoreductase, isomerase and chaperone effects, the latter not directly dependent on
its thiols. PDI is a converging hub for pathways of disulfide bond introduction into ER-processed proteins, via hydrogen peroxide-generating mechanisms
involving the ER flavooxidase Ero1α, as well as hydrogen peroxide-consuming reactions involving peroxiredoxin IV and novel peroxidases Gpx7/8. A
situation in which ER-dependent reactive oxygen species (ROS) generation is increased in many cell types is ER stress. PDI is a candidate pathway for
coupling ER stress to ROS generation. Emerging information suggests a convergence between PDI and Nox family NADPH oxidases. In vascular smooth
muscle cells, PDI silencing prevents Nox responses to angiotensin-II and inhibits Akt phosphorylation in vascular cells. Also PDI is required for Nox1/ROSdependent vascular smooth muscle cell migration through pathways involving small GTPases Rac1 and RhoA, while PDI silencing promotes cytoskeletal
disruption. PDI overexpression spontaneously enhances Nox activation and expression. During acute ER stress in smooth muscle cells, silencing of either
Nox4 or PDI abolishes ROS generation, while PDI silencing enhances apoptosis. During sustained ER stress, ROS generation correlates with increased
apoptosis, but does not induce cell death. At the cell surface, PDI mediates redox-dependent adhesion, coagulation/thrombosis, immune functions and
virus internalization. The route of PDI externalization remains elusive. Thus, such multiple effects renders PDI(s) putative redox cell signaling adaptors of
broader significance. Altogether, redox pathways associated with (patho)physiological protein folding are prime candidate reg ulators of cellular redox
status in many diseases (Research supported by: FAPESP, CNPq/INCT Redoxoma).
64
Symp#13 Vascular cell biology
Chair Robson Monteiro
Tumor-Derived Microvesicles and their Role in Cancer Progression
Robson Q. Monteiro
Institute of Medical Biochemistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
Shedding of phosphatidylserine (PS)-containing microvesicles (MVs) by cancer cells have been correlated with several pro-tumoral
responses. In addition, the procoagulant properties of MVs suggest their involvement in the establishment of cancer-associated
prothrombotic states. Comparison of MVs produced by a non-tumorigenic melanocyte-derived cell line (melan-A) with its
tumorigenic melanoma counterpart, Tm1, showed an increased rate of MVs production upon malignant transformation. Moreover,
tumor-derived MVs displayed increased levels of the clotting initiator protein, tissue factor (TF). As a result, Tm1 but not melan-aderived MVs accelerated thrombosis in vivo. Analysis of plasma obtained from melanoma-bearing mice showed the presence of MVs
with a similar procoagulant pattern as compared to Tm1 MVs produced in vitro. Remarkably, flow-cytometric analysis demonstrated
that 60% of ex-vivo MVs are TF-positive and carry the melanoma-associated antigen, demonstrating its tumor origin. These data
reinforce the possible involvement of tumor-derived MVs in the establishment of cancer-associated hypercoagulant states, indicating
an important role for TF in this process. Since MVs may horizontally transfer their cargo between different cells, we further
investigated the exchange of TF-bearing MVs between human breast cancer cell lines with different aggressiveness potential.
Incubation of low aggressive MCF-7 cells with MVs from the aggressive cell line, MDA-MB-231, rendered a significant gain of TF
activity. This phenomenon was not observed upon pretreatment of MVs with an anti-TF neutralizing antibody or annexin V, which
blocks PS sites on MVs surface. These data indicate that TF-bearing MVs can be transferred between different populations of cancer
cells, and thus may contribute to the propagation of a TF-related aggressive phenotype among heterogeneous cell subsets present in
the tumor microenvironment.
This study was supported by the Brazilian agencies CNPq and FAPERJ.
Cell Adhesion and Signaling Pathways in Neurovascular Development
Joseph H. McCarty
Department of Cancer Biology, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas, 77030,
U.S.A.
The mammalian central nervous system contains billions of neurons and glia that are interlaced with an elaborate network of blood
vessels comprised of endothelial cells, pericytes and vascular basement membranes. During development blood vessels grow and
sprout along a pre-formed latticework of glial cells; however, the mechanisms by which glial cells control central nervous system
neovascularization remain enigmatic. We have used Cre-lox strategies in mice to demonstrate that αvβ8 integrin expressed in glial
cells is essential for neovascularization of the developing central nervous system. Cell type-specific inactivation of αv or β8 integrin
gene expression in radial glia using a Nestin-Cre transgene leads to the development of hemorrhagic blood vessels that form
glomeruloid-like tufts in the embryonic brain and the neonatal retina. These pathologies correlate with diminished activation of latent
TGFβs, which are extracellular matrix-bound protein ligands for αvβ8 integrin. Genetic ablation of canonical TGFβ receptors Alk5 or
TGFβR2 in vascular endothelial cells during embryogenesis result in brain vascular pathologies that are identical to those in integrin
conditional knockout mice. Furthermore, tamoxifen-inducible inactivation of TGFβ receptor signaling in retinal endothelial cells also
leads to defective angiogenesis and intraretinal hemorrhage. Collectively, our data demonstrate that αvβ8 integrin and TGFβ
receptors are components of a paracrine signaling axis that links glial cells to endothelial cells during central nervous system vascular
development.
Vascular growth factor signaling in neurogenesis
Jean-Léon Thomas#, Anne Eichmann*
Departments of Neurology# and Cardiovascular Medicine*, Yale School of Medicine, New Haven, CT, USA
#
Brain and Spinal Cord Institute, Paris, France
In the adult mammalian brain, the potential to generate new neurons is restricted to a limited number of sites called neurogenic
niches, which are localized in the subventricular zone (SVZ) lining the cerebral ventricles and in the dentate gyrus (DG) of the
hippocampus. Injury of brain tissue resulting from trauma or pathologies activates neurogenesis in these niches, attesting to an
endogenous repair potential that is generally not sufficient to allow a complete rescue. To enhance this endogenous neurogenic
response without negative side effects, it is crucial to characterize the mechanisms which are active in neurogenic niches.
Functionally, members of the vascular endothelial growth factor (VEGF) family stimulate adult neurogenesis and neuronal plasticity,
opening potential approaches for repair of neurodegenerative diseases. However, it has been unclear whether VEGFs stimulate
neurogenesis directly via VEGF receptors (VEGFRs) expressed by neural cells, or indirectly via the release of growth factors from
angiogenic capillaries. We have reported that the lymphangiogenic growth factor VEGF-C is expressed by neural cells and provides
trophic support to neural progenitor cells during brain development (Le Bras, Nat Neurosci, 2006). Here, we will discuss our latest
findings on its receptor VEGFR-3, which is expressed by adult NSCs, and is critical for adult neurogenesis by acting directly in NSCs and
niche astrocytes, but not endothelial cells (Calvo, Genes Dev., 2011).
65
Symp#14 Cell cycle control mechanisms
Chairs Patricia Gama and Hugo Aguirre Armelin
Stabilizing nuclear p27kip1 with Skp2/Cks1 E3 ligase inhibitors as a potential therapeutic intervention for endometrial cancer and
other cancers
Savvas C. Pavlides, Lily Wu, Kuang-Tzu Huang, Stepahnie V. Blank, Khushbakhat Mittal, Timothy Cardozo, and Leslie I. Gold
School of Medicine, New York University, USA
The cell cycle is precisely regulated via the ubiquitin-proteasome system (UPS) by three substrate-specific E3 ubiquitin ligases, APCCdc20, APC-Cdh1, and SCF-Skp2/Cks1. Inhibitors of specific E3 ligases that degrade proteins involved in cell cycle arrest are significant
targets to block for cancer therapy and a significant improvement over currently used non-specific proteasome inhibitors. The cyclindependent kinase inhibitor, p27kip1 (p27), is important for cell cycle arrest in G1. SCF-Skp2/Cks1 ubiquitylates nuclear p27 targeting it
for degradation thereby causing cell cycle progression. In turn, APC-Cdh1 signals Skp2 and Cks1 degradation, maintaining abundant
levels of p27 for cell cycle arrest. We show perpetual degradation of p27 by the UPS in type I endometrial carcinoma (ECA), an
estrogen (E2)-induced cancer. Using normal human primary endometrial epithelial cells (EECs), we demonstrate that E2 induces
MAPK-Erk2-driven ubiquitin-mediated degradation of p27 by its phosphorylation at T187, required for its degradation by SCFSkp2/Cks1. Also, E2 decreases APC-Cdh1 to increase Skp2 and Cks1 levels for p27 degradation. We propose that E2-induced
degradation is involved in the pathogenesis of ECA because knocking-down Skp2 completely blocks E2-induced p27 degradation and
growth stimulation. Conversely, progesterone (Pg) and TGF-β, both inhibitors of EEC growth, markedly increase p27 by increasing
Cdh1 thereby causing destruction of Skp2/Cks1 leaving p27 intact. Accordingly, separately knocking-down Cdh1 and TGF-β obviate
both Pg- and TGF-β-induced stabilization of nuclear p27 and completely blocks their ability to inhibit growth. These studies suggest
that preventing p27 degradation is a rational therapeutic strategy for the treatment of type I ECA. Indeed, small molecule inhibitors
of Skp2 E3ligase activity (Skp2E3LIs) shown in silico to block p27 binding to Skp2-Cks1, inhibit both E2-induced proliferation and
degradation of p27 in an ECA cell line and in primary ECA cells. Significant progress has been made in vitro showing lack of toxicity
and that certain Skp2E3LIs specifically block nuclear degradation of p27 where it can inhibit Cdk1 for cell cycle arrest. Skp2E3LIs
provide tools for understanding the role of the UPS in p27-mediated cell cycle regulation and as a novel approach to treating ECA and
many other cancers with inverse levels between p27 and Skp2.
Cyclin F-mediated degradation of RRM2 (Ribonucleotide Reductase family member 2) controls genome integrity and DNA repair
Vincenzo D’Angiolella1, Valerio Donato1, Frances M. Forrester1, Yeon-Tae Jeong1, Claudia Pellacani1, Yasusei Kudo1,2, Anita Saraf3,
Laurence Florens3, Michael P. Washburn3,4, and Michele Pagano1,5
1
Department of Pathology, NYU Cancer Institute, New York University School of Medicine, 522 First Avenue, SRB 1107, New York, NY
10016, USA. 2Department of Oral Molecular Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School,
Tokushima, Japan. 3The Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA. 4Department of
Pathology and Laboratory Medicine, The University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, Kansas 66160,
USA. 5Howard Hughes Medical Institute
F-box proteins are the substrate recognition subunits of SCF ubiquitin ligase complexes. The F-box protein family obtained its name
from Cyclin F (also known as Fbxo1), in which the F-box motif was first described. Cyclin F is localized both to the centrosomes and
the nucleus. At the centrosomes, Cyclin F targets CP110 for proteasomal degradation during G2 to limit centrosome duplication to
once per cell cycle. Instead, the nuclear function of Cyclin F remains elusive. Using purifications and mass spectrometry, we
identified RRM2 (the ribonucleotide reductase family member 2) as a new interactor of the F-box protein Cyclin F. Ribonucleotide
reductase (RNR) catalyzes the conversion of ribonucleotides to the deoxyribonucleotides (dNTPs) that are necessary for replicative
and repair DNA synthesis. Because of this fundamental function, RNR is among the most well-conserved (from prokaryotes to
eukaryotes) and highly-regulated enzymes. Indeed, an unbalanced and/or increased dNTP pools produce a hypermutator phenotype,
and decreased dNTP levels interfere with proper DNA replication and repair. We found that, during G2, following CDK-mediated
phosphorylation of Thr33, RRM2 is degraded via SCFCyclin F to maintain balanced dNTP pools and genome stability. After DNA damage,
Cyclin F is downregulated in an ATR-dependent manner to allow accumulation of RRM2. Defective elimination of Cyclin F delays DNA
repair and sensitizes cells to DNA damage, a phenotype that is reverted by expressing a non-degradable RRM2 mutant. In summary,
we have identified a novel biochemical pathway that controls the abundance of dNTPs and ensures efficient DNA repair in response
to genotoxic stress.
Resveratrol and Temozolomide co-treatment induces mitotic catatrophe and senescence in glioma cells through modulation of
mitotic regulators
Eduardo C. Filippi-Chiela and Guido Lenz*
Department of Biophysics and Center of Biotechnology,
Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Email: [email protected] Phone: 55 51 33087613
Blockage of the cell cycle is an important strategy in cancer therapeutics. On the other hand, forcing mitosis in cells with high levels of
DNA damage may also be a good strategy, since it may induce mitotic catastrophe (MC) and senescence. Temozolomide (TMZ), the
primary therapy used in gliomas, causes DNA damage and G2 arrest. Resveratrol (Rsv) presents additive toxicity with TMZ in several
glioma cells in vitro and in vivo, but the mechanism of additive toxicity is not clear, which is the aim of the present work. Rsv
abrogated the TMZ-induced G2 arrest when added together, but not after TMZ. Rsv potentiated the increase in TMZ-induced
gammaH2AX, but not ATM and Chk2. Abrogation of TMZ-induced cell cycle arrest by Rsv involved a reduction of cyclin D,
pWee1(S642) and of the Wee1 target site, pCdc2(Y15) and increase of cyclin B. This suggests a state of forced passage through G2
checkpoint despite large DNA damage, a scenario typical of MC. In order to quantify MC and senescence, we developed a quantitative
method called nuclear morphometric analysis (NMA). Indeed, after acute treatment with Rsv+TMZ, the proportion of cells with high
nuclear irregularity increased from 5 to 28% in 48h. Seven days later, a large induction of senescence and reduction in clonogenicity
was observed. In conclusion, presence of Rsv forced damaged cells treated with TMZ through mitosis due to a reduction of Wee1 and
pCdc2(Y15), leading to MC and senescence. Funding: CNPQ and FAPERGS. No conflict of interest.
66
Symp#15 Migration and Regeneration
Chair Fernando Costa e Silva Filho
A mechanochenical cross-talking between eukaryotic cells and their surroundings instruct cells on what they have to
do
1*
2
1
1,3
Fernando Costa e Silva Filho , Nathan Bessa Viana , Lilian de Mello Gil , and Débora Barreiros Petrópolis
1,2
1
2
3
UFRJ- Instituto de Biofísica Carlos Chagas Filho and Instituto de Física (Brazil), Institute Pasteur (France),
1,3
and INCT- Instituto Nacional de Pesquisa Translacional em Saúde e Ambiente da Região Amazonica (Brazil)
Collagen I (COL) is abundant in the extracellular matrix (ECM) of most of studied animal tissues and one of the most
widely-used scaffolds for three-dimensional (3D) cell culture and tissue engineering applications, which is partly
derived from the ability of purified COL monomers to self-assemble into stable, 3D gels at physiological pH. The fiber
diameter, pore size, and bulk elasticity of reconstituted COL gels can be tuned within modest ranges by changing COL
concentration, ionic strength, pH, and the temperature of gelation. The last in turn begins with the entropy-driven
nucleation of triple-helical COL monomers into small aggregates, which subsequently self-assemble into thin filaments
that laterally crosslink into the well known COL fibers. A 3D COL matrix is then formed via non-covalent entanglement
of the fibers. As a consequence of this entanglement, reconstituted COL networks or meshes typically exhibit nonaffine mechanical properties which means applied stresses are dissipated non-uniformly throughout meshes via
sliding, slipping, bending, and bucking of individual COL fibers. Given such 3D COL properties which partially mimic the
mechanical configuration of naturally occurring ECM we have been used COL meshes under different mechanical
configurations to explore further the responsiveness of some protozoa and mammalian cells to the mechanics of their
surroundings. Trophozoitic forms of the parasitic protozoan E. histolytica (HM1:IMSS) and human osteoblasts (HOB)
are cells we have elected to investigate the mechanisms underlying the interaction between eukaryotes and each one
of 2D (biofilms) and 3D (meshes) COL setups by using biophysical, biochemical, structural and ultrastructural methods
as well as optical tweezers. Altogether, the resulting data we have obtained clearly show that the early response of a
protozoan and a mammalian cell to a same mechanochemical environment is quite different: while HM1:IMSS cells
tend to use COL fibers as migration tracks, HOB cells tend to remodel the mesh at high extent following invasion.
Inside-out integrin signaling
Mark Ginsberg
University of California, San Diego, Department of Medicine, La Jolla, CA
Integrin activation contributes to leukocyte trafficking, cell migration and extracellular matrix assembly. Deletion of
talin or point mutations in talin or integrins that disrupt their interaction led to profound defects in integrin
activation. We reconstructed integrin activation in vitro and found that that talin binding is sufficient for activation.
Talin interaction with phospholipids is required for its capacity to activate integrins. Nanodiscs bearing a single lipidembedded integrin and revealed that talin activates unclustered integrins leading to molecular extension in the
absence of force or other membrane proteins. Rap1 small GTPases are important in activation of integrins and we
report that they interact with RIAM (Rap-interacting Adaptor Molecule) to promote talin-dependent activation. RIAM
connects the membrane targeting sequences in Ras GTPases to talin, thereby recruiting talin to the plasma membrane
and activating integrins. A minimized 50 residue Rap-RIAM module, containing the talin binding site of RIAM joined to
the membrane-targeting sequence of Rap1A is sufficient to target talin to the plasma membrane and to mediate
activation in the absence of Rap1 activity. The structure of the αIIbβ3 transmembrane domain (TMD) reveals how talin
binding can disrupt the αβ TMD complex and lead to the long range conformational change that results in integrin
activation. These studies define the molecular mechanisms whereby talin activates integrins and establish a signaling
roadmap between agonist stimulation and integrin activation.
Human-laminin mediates axonal regeneration promoted by human adipose tissue-derived stromal cells after spinal
cord injury in rats
Tatiana Coelho Sampaio
Universidade Federal do Rio de Janeiro, Instituto de Ciências Biomédicas, Departamento de Histologia e Embriologia,
Rio de Janeiro, Brasil
Adipose tissue is a convenient source of adult mesenchymal cells for regenerative therapies. We injected human
adipose tissue-derived stromal cells (hADSC) after acute spinal cord injury in immunocompetent rats and found that
they promoted extensive morphological and functional recuperation. In contrast to controls, treated animals
presented 1) clusters of neural precursors in the spinal parenchyma, 2) blood vessels with double basement
membranes and 3) abundant deposition of laminin of human origin at the lesion site and spinal midline. These effects
did not occur upon treatment with conditioned medium, but did occur after injection of hADSC into the non-injured
cord. Fibers positive for 5-HT, Beta III tubulin or GAP-43 were visible in the tissue surrounding the cystic cavity in close
association with laminin. We propose that laminin is the main effector of hADSC-induced axonal regeneration and that
it acts by increasing the amount of local neural precursors.
67
Symp#16 Inflammation
Chair Patrícia Bozza
Patrícia Bozza
Introductory notes
The intimate link between fibrosis and inflammatory response
Niels Olsen Saraiva Camara
Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, São Paulo, Brazil
Toll-like receptors (TLRs) are an innate family of receptors that can sense tissue damage and orchestrate a cascade of
inflammation. Recent reports have shown reduced fibrosis in TLR4-deficient mice. TLR2 and TLR4 signal via the
intracellular adaptor molecule MyD88, although only few studies implicated a role for MyD88 in fibrosis. TLRs
modulate the immune system through the production of different cytokines and influence fibrosis. In fact, fibrosis is
strongly linked with the development of a Th2-biased response (involving IL4, IL5 and IL13). Macrophages are
considered to play a pivotal role in the development of fibrosis. Recent studies raise the possibility that the effector
phenotype of the recruited macrophages, rather than their presence, determines the extent of renal parenchymal
injury. Macrophages are classified in distinct subpopulations according to their response to innate or adaptive immune
signals. The term “classically activated” has been used to designate the effector macrophages that are produced
during cell-mediated immune responses. Such macrophages are also designated M1 macrophages and express iNOS,
CXCL9, CCR7, CXCL11, IL12 and IFNγ. On the other hand, one of the first innate signals released during tissue injury is
thought to be IL4, an inducer of “alternatively activated” or M2 macrophages. Since collagen deposition is a hallmark
of all chronic diseases, preceded by the development of sterile inflammation, which can be modulated by the presence
of cytokines, here, we present data that MyD88-depend pathway could be involved in sensing these tissue alterations
and in favoring a Th2-prone pro-fibrotic immune response.
How a Parasite MIF Suppresses T cell Immunity and Influenced the Evolution of Macrophage Responsiveness
Rick Bucala MD PhD, Yale University, New Haven, CT.
The inability to acquire protective immunity against Plasmodia is the chief obstacle to malaria control, and an
inadequate T cell response may contribute to persistent blood stage infection. We observed that high levels of
inflammatory cytokines inhibit Plasmodium-specific memory T cell development and result in fewer protective
memory T cells. The Plasmodium ortholog of macrophage migration inhibitory factor (MIF), which is produced during
infection, is associated with inflammatory sequelae in human malaria and induces high levels of pro-inflammatory
cytokine expression. Using a genetically targeted strain of P. berghei, the Plasmodium MIF (PMIF) mediated increase in
inflammatory cytokine expression was found to promote T cell apoptosis, resulting in fewer antigen-experienced CD4 T
cells that become memory cells. CD4 T cells activated in the presence of PMIF fail to produce robust anti-malaria recall
responses during a secondary challenge infection and are unable to control parasitemia. These results indicate that
Plasmodia modulate the adaptive immune response and interfere with the generation of malaria-specific memory CD4
T cells, thereby facilitating parasite persistence and transmission. The immunoregulatory function of PMIF may
account for its expression across all Plasmodium spp., its evolutionary conservation in protozoan and helminthic
parasites, and the prevalence of low expression MIF alleles in many human populations. Targeting PMIF may be a
useful approach for augmenting natural host immunity and for producing more effective vaccines.
68
Symp#17 Glia
Chair Flávia Carvalho Alcântara Gomes
GLAST/EAAT1 induces Glutamine release through SNAT3 in cultured chick cerebellar Bergmann glial cells
1
2
Angelina Rodriguez and Arturo Ortega
1
2
Facultad de Química, Universidad Autónoma de Querétaro, Querétaro, Mexico., Departamento de Genética y
Biología Molecular, Cinvestav-IPN, México DF, Mexico.
Glutamate is the main excitatory neurotransmitter in the vertebrate brain. Once released, its extracellular levels are
tightly regulated through the action of a family of sodium-dependent glutamate/aspartate transporters profusely
expressed in glial cells. Once internalized into the glial compartment, it is metabolized by glutamine synthetase to
glutamine and released to the synaptic space through sodium-dependent neutral amino acid carriers of the N System.
Glutamine is then taken up by neurons via System A transporters completing the so-called glutamate/glutamine
shuttle.
Although this neuronal/glial coupling was described decades ago, it has only been recently that the biochemical
framework that supports this shuttle has begun to be elucidated. Using the established model of cultured cerebellar
Bergmann glia cells from chick cerebellum, we characterized the functional and physical coupling of glutamate uptake
and glutamine release. A time-dependent glutamate transporter-induced glutamine release could be demonstrated.
Furthermore, D-aspartate, a specific glutamate transporter ligand, was capable to enhance the coimmunoprecipitation of the glutamate and glutamine transporters, whereas glutamine tended to reduce this
association. Our results clearly pointout that glial cells that enwrap glutamatergic synapses act as sensors of neuronal
activity and through their contribution to the neurotransmitter recycling, could well the rate-limiting step of
glutamatergic synaptic function.
Understanding Neuron-Glia Interactions: Models Matter
Frank W. Pfrieger
Institute of Cellular and Integrative Neurosciences, CNRS UPR 3212, University of Strasbourg, Strasbourg, France
Brain development and function depend on interactions of neurons and different type of glial cells. Within the last
years, we have developed new experimental approaches that allow to study these interactions in vitro and in vivo,
with a focus on the retina. In my presentation, I will summarize our results, which indicate contributions of astroglial
cells to synapse development, neuronal volume regulation and cholesterol homeostasis in the brain.
Adan Aguirre
Department of Pharmacological Sciences, 442 Center for Molecular Medicine, Stony Brook University, , Stony Brook,
NY 11794-5140
69
Symp#18 Perspectives in cancer therapies
Chair Jörg Kobarg
Prospecting and testing new molecular target proteins for cancer therapy: integrating systems and structural
biology”
Jörg Kobarg, PhD
LNBio-Laboratório Nacional de Biociências, CNPEM-Centro Nacional de Pesquisa em Energia e Materiais
Rua Giuseppe Máximo Scolfaro 10.000 Campinas-SP, Brasil, CEP 13083-970 F: 0055-19-3512-1125
Starting from identified cancer related proteins or candidate proteins we explore and integrate several techniques and
approaches ranging from structural biology, micro array, proteomics, protein interactome to cellular and molecular
functional characterization, in order to obtain information on the mechanisms underlying the dysfunction of these
proteins in cancer and to envision new modes of interference aiming at the target specific therapeutic intervention in
cancer. Distinct aspects of this approach are exemplified by three different proteins or groups of proteins currently
under investigation: 1. FEZ1 as a kinesin associated transport adaptor protein that when over-expressed can lead to
the formation of so called “flower-like nuclei“, a hall mark of certain aggressive sub-types of leukemia. 2. Il-7 Receptor
Cys insertion mutations that lead to aberrant receptor homo-dimerization and constitutive activation , growth and
survival of lymphocytes and to tumor formation in the mice model. 3. The 11 human members of the family of NIMA
(Never in mitosis gene A)-related serine/threonine kinases (Neks) have cell cycle-related functions, were recently
described as related to pathologies, particularly cancer, and present promissing chemotherapeutic targets. In order to
understand better the cellular functions of human Nek kinases we performed yeast two-hybrid assays using Nek1, 6, 7
and 9 as baits to identify their protein interaction partners. Similar studies are currently ongoing for Nek 3, 4, 5, 10 and
11. We will present a general overview of our results and their implications for these protein kinases functions in the
context of tumorigenesis.
Modern optical techniques for diagnostic and treatment of cancer and microorganisms
Vanderlei S. Bagnato
Instituto de Física de São Carlos, Universidade de São Paulo, São Carlos, Brazil
Solving health problems with photonics techniques is attractive due to its more selective and fast response, minimally
or non-invasive procedure, and potential low cost instrumentation. These characteristics are especially relevant for
emergent economy countries, where health care is still deficient for large amount of population. Brazil shows a diverse
situation along its large territory: it is possible to find the best medicine with the highest technology available and well
educated personnel, but also a poor health care or even the lack of one. Diagnostics and treatment techniques that are
effective, low cost, and that requires simple instrumentation may be good solutions for improving health care. This
presentation will start with the main principles involved in photonics for live science and present the status of
development for applications in cancer diagnostic and treatmne as well as microbial control.
Deciphering Neuregulin-HER signaling in breast cancer
Atanasio Pandiella
Centro de Investigación del Cancer. CSIC-Universidad de Salamanca, Spain.
The ErbB/HER receptors and their ligands play important roles in animal physiology, and their deregulation has been
linked to diseases such as cancer. Activation of the HER receptors may occur by different mechanisms, including ligand
binding, receptor overexpression, or molecular alterations. In breast cancer, one of the HER family recptors, termed
HER2, is overexpressed in tumors of 20% of patients, and this has led to the development of therapies against HER2
which are now routinely used in the breast cancer clinic. While assessment of the levels of HER receptors in breast
cancer has been extensively analyzed, the role of their ligands has been less well studied. We have explored the
expression of Neuregulins (NRGs), a subgroup of HER ligands, in breast cancer samples. We observed frequent
expression of these ligands, and such expression was linked to metastatic dissemination and poor clinical outcome,
indicating that targeting this ligand system may be therapeutically beneficial. For this reason, we have started a
program to identify how the NRG-HER signaling system controls the proliferation of breast cancer cells. Genomic as
well as proteomic strategies have allowed us to identify novel signaling intermediates of the NRG-HER system. Using
biochemical, genetic, cell biological techniques, as well as xenografted mice, we have elucidated the participation of
these novel signaling intermediates in NRG-stimulated proliferative responses in breast cancer cells. Pharmacological
action on some of these intermediates allowed us to evaluate the potential therapeutic value of their targeting in
breast cancer.
70
Symp#19 Regulators of neural transmission
Chairs Vilma R Martins and Roy Larson
Regulation of neuronal function and dysfunction by protein SUMOylation
Jeremy M. Henley
University of Bristol
The post-translational modification SUMOylation is a major regulator of protein function that plays an important role
in a wide range of cellular processes. SUMOylation involves the covalent attachment of a member of the small
ubiquitin-like modifier (SUMO) family of proteins to lysine residues in specific target proteins via an enzymatic cascade
analogous to, but distinct from, the ubiquitination pathway. The implications for neuronal protein SUMOylation are
far-reaching in both normal cell function and in neurological and neurodegenerative diseases. I will discuss aspects of
our work attempting to identify and functionally characterise SUMO substrates; elucidate the molecular mechanisms
regulating, and consequences of, substrate SUMOylation and deSUMOylation; determine the activity-dependence of
SUMO and SUMO-specific protease trafficking to synapses; and define how SUMOylation regulates synaptic
transmission under basal, stimulated and pathological conditions.
Gain control in the outer retina
1,2
1
Joselevitch, C. , Kamermans, M.
1 - Retinal Signal Processing, The Netherlands Institute for Neuroscience; The Netherlands.
2 - Department of Experimental Psychology, Universidade de São Paulo, Brazil.
Gain control mechanisms are present at all retinal layers. They are especially important for cells that receive mixedinput from rods and cones, in order to avoid premature saturation as light levels increase. Here we describe a
mechanism at work in the goldfish retina that modulates the effectiveness of the rod-bipolar cell synapse. Voltageclamp recordings of mixed-input ON bipolar cells in retinal slices show that a voltage-gated current is activated during
the light-induced depolarization at scotopic levels. The activation of this current effectively diminishes the amplitude
of the bipolar cell rod-driven light response and makes it faster and more transient with increasing light intensity. This
+
+
effect can be abolished by the K channel blocker TEA, which indicates that the voltage-gated current is mediated by K
+
ions. Mathematical simulations with NEURON suggest that the K channels are most likely concentrated at the
dendritic tips of mixed-input ON bipolar cells, close to the site of glutamate release by photoreceptors. Since the
magnitude of activation of such channels depends directly on the amplitude of the light response, they control the
gain of the rod bipolar cell synapse and speed up synaptic transmission as light levels increase and rod responses
themselves inactivate slowly.
Protein synthesis and memory processing
Martin Cammarota
Instituto de Pesquisas Biomédicas, PUCRS, Porto Alegre, Brazil
71
Symp#20 Tissue Regeneration
Chair Juan Larrain
Spinal cord regeneration in Xenopus
1
1
1,
1
2
1
Rosana Muñoz , Dasfne Lee-Liu Mauricio Moreno , Gabriela Edwards , Leonardo I. Almonacid , Victor Tapia , Karina
1
2
1
Tapia , Francisco Melo , Juan Larrain
1
Center for Aging and Regeneration and Millenium Nucleus in Regenerative Biology, Department of Cell and Molecular
2
Biology, Pontificia Universidad Catolica de Chile; Molecular Bioinformatics Laboratory, Millennium Institute on
Immunology and Immunotherapy, Department of Molecular Genetics and Microbiology, Pontificia Universidad
Catolica de Chile.
Xenopus tadpoles are able to regenerate the spinal cord (SC) after injury, although this capacity is lost when they reach
metamorphosis. The cellular and molecular mechanisms that explain this differential SC regeneration ability have not
been unveiled (or are not completely understood). Thus, a deep comparison between the regenerative capacities in
these two stages of Xenopus life cycle might be crucial to establish why SC regeneration is lost during metamorphosis.
+
We have found that spinal cord transection activates proliferation of Sox2 cells from the ependymal layer in
+
regenerative but not in non-regenerative stages. At 6 days post transection (dpt) Sox2 cells fill the gap between the
spinal cord stumps and provide a surface for axonal regeneration.To deepen this analysis, we propose that the
differences in regeneration capacity can be explained at least at the level of gene expression. Thus, we aim to identify
a group of SC transcripts that are permissive and another non-permissive for regeneration. To demonstrate this we
performed a high-throughput analysis of the SC transcriptome (RNA-Seq) after injury (transection) in different stages.
So far, we have found that more than 4000 transcripts show differential expression when comparing regenerative and
non-regenerative stages. We have successfully validated these differences in a group of them using qRT-PCR. And
importantly, gene ontology enrichment analyses show that genes belonging to the biological processes ‘cell cycle’ and
‘immune response’ are differentially regulated after spinal cord injury, amongst others. Considering these preliminary
results we suggest that the differences in SC regeneration capacities in Xenopus could be explained at least by a
differential expression of cell cycle and immune response genes.
Cellular and Molecular Mechanisms of Zebrafish Heart Regeneration
Ken Poss
HHMI, Duke University Medical Center, Durham, USA
Cellular and molecular mechanisms of intestinal regeneration in echinoderms
Jose E. García-Arrarás
University of Puerto Rico
In recent years we have seen a growing interest in determining the cellular and molecular mechanisms involved in the
process of organ regeneration. This process comprises a sequence of temporal and spatial events that interact to give
rise to a new organ. We have studied the regeneration of the digestive tract using as a model system the sea cucumber
Holothuria glaberrima. This echinoderm, like many other holothurians, has the capacity to regenerate most of its
digestive tract following its loss. We have shown that the new intestinal primordium is a blastema-like structure that
forms as the mesenterial cells undergo a series of changes that include dedifferentiation, proliferation and apoptosis.
These cells undergo changes at the molecular level, expressing molecular markers not normally found in the normal
mesentery. Among the molecular markers that appear to be over-expressed within the epithelial cells during the
formation of the intestinal rudiment are those associated with signalling pathways such as Wnt 9 and BMP1/TLD, with
the control of cellular proliferation and cell death such as TCTP, survivin, and mortalin and with the ubiquitinproteasome system. The drastic changes observed in the expression profile of the epithelial component suggest that
these cells are the key players in the regeneration process and provide a target to further explore their role in organ
regeneration. Thus, as we unravel the cellular and molecular mechanisms associated with intestinal regeneration in
echinoderms we provide a much-needed insight into the basic biological processes involved in organ regeneration.
Funded by NIH (1SC1GM084770), NSF (IOS-0842870) and the University of Puerto Rico
72
Symp#21 Metabolic programming
Chair James Armitage
Maternal obesity, diabetes or high fat intake in pregnancy: Are they all independent risk factors for metabolic
syndrome in her offspring?
James A Armitage
Department of Anatomy and Developmental Biology
Monash University, Victoria, Australia
In many societies across the globe, more than half of the women of reproductive age are overweight or obese.
Maternal obesity and diabetes in pregnancy have long been recognised as risk factors for adverse pregnancy
outcomes, including emergency caesarean section, shoulder dystocia and perinatal complications.
More recently we have also come to appreciate the fact that maternal obesity or diabetes may also programme
metabolic, cardiovascular and renal dysfunction in her offspring. Our studies in diabetic mice show that maternal
hyperglycaemia programmes abnormal fetal growth and a reduction in kidney development, which occurs from the
earliest time points of kidney development and may result in lifelong alterations in renal function.
In addition to the obesity epidemic, humans across the globe are consuming diets very high in fats and oils, particularly
saturated fatty acids. At present it is not known whether consumption of a high fat diet is sufficient to programme
metabolic cardiovascular or renal disease in the offspring.
We developed a rodent model to better understand the role of maternal fat intake in pregnancy without the confound
of maternal obesity and show that high saturated fat intake in pregnancy and suckling programmes offspring
hypertension and altered renal function independent of maternal or offspring obesity. The mechanisms underlying this
programming may relate to placental fatty acid transfer and cytokine production in late gestation.
In conclusion, maternal diabetes and excessive maternal saturated fatty acid intake can programme alterations in
kidney development and function independent of maternal obesity. Given the preponderance for high saturated fat
intake, and the increasing prevalence of diabetes in women of reproductive age, these findings offer strong evidence
for moderation of fat intake in pregnancy and careful management of hyperglycaemia in pregnant women.
SMOKING IN THE POSTNATAL LIFE AND FUTURE OBESITY: the nicotine role on the endocrine dysfunctions.
Patricia Cristina Lisboa
Laboratory of Endocrine Physiology, Department of Physiological Sciences, Biology Institute, State University of Rio de
Janeiro, RJ.
Around 40% of children worldwide are exposed to tobacco smoke at home. Children born from smoking mothers
present several developmental impairment. Environmental changes in a critical window of development, such as
gestation or lactation, can cause permanent alterations in the metabolism, leading to disease at adulthood; a
phenomenon called programming or developmental plasticity, which is based on epigenetic alterations (DNA
methylation and histone acetylation) that change the pattern of expression of several genes involved with the
metabolism regulation. A histone deacetylase, Sirt1 is inhibited by nicotine and can play an importante role in the
developmental plasticity. Obesity is a global epidemic and it has been shown an association of maternal smoking with
the development of obesity in childhood. However, little is known about the early and late effects of the tobacco in
neonatal life upon adiposity and endocrine function. We studied two models of programming related to smoking that
produced animals with higher cardiovascular risk and endocrine dysfunction during development: maternal nicotine
exposure (i) and maternal cigarette smoke exposure (ii), both only during lactation. We evidenced a relationship
between hyperleptinemia in offspring whose mothers were exposed to nicotine during lactation with the further
development of leptin and insulin resistance as well as thyroid and adrenal dysfunctions in adulthood. Thus, an
environment free of smoke during lactation is essential to improve health outcomes in adult life, reducing the risk for
future diseases. The knowledge about the pathophysiological mechanisms involved in maternal smoking can give new
insight concerning therapeutic strategies for obesity.
Diet-induced hypothalamic inflammation in obesity
Licio A. Velloso
University of Campinas, Brazil
Obesity results from the failure of the homeostatic control of caloric intake and energy expenditure. Most of this
control is exerted by a complex network of hypothalamic neurons that integrate hormone, nutrient and neuronal
signals involved in the sensing and responsiveness to the fluctuations of the body energy stores. Data obtained in the
latest fifteen years have placed hypothalamic dysfunction in a central position in the pathogenesis of obesity. Here, we
will review the seminal work that have contributed to our current knowledge of the mechanisms involved in the
control of food intake and thermogenesis and also the implications of hypothalamic dysfunction in the development of
obesity. We will present data from both experimental and human studies showing that saturated fats present in the
western diet can activate hypothalamic inflammation which results in the defective control of energy homeostasis.
73
Symp#22 Mitochondria
Chairs Enilza Espreafico and Nadja Souza-Pinto
Evidence implicating KIAA0090/CG2943 in mitochondrial function
ENILZA M ESPREAFICO, RODRIGO R SILVA, CARLOS A COUTO LIMA, ROBERTO A. MOLINA, JOSANE F SOUSA, MILENE M
LOPES, MAIARO C MACHADO, LUCAS ANHEZINI, RICARDO GP RAMOS
Departamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirão Preto,
Universidade de São Paulo, 14049-900 - Ribeirão Preto, SP, Brasil
Human KIAA0090 is an evolutionarily conserved and ubiquitously expressed gene that maps to a chromosomal region (1p36.13) with
frequent aberrations in cancer. It is a complex gene with cDNA sequences in databases supporting the occurrence of more than 20
alternative transcripts. The RefSeq transcript is predicted to encode a 993 aa transmembrane protein whose S. cerevisiae ortholog
(EMC1) was recently proposed to function on transmembrane protein folding in the endoplasmic reticulum (ER). Deletion of the gene
in yeast and C. elegans leads to slow growth and a number of interactors involved in multiple pathways, including cell cycle, secretory
pathway, UPR, ERAD, ion transport, cytoskeleton, transcription factors, and mitochondrial electron transfer, have been detected. We
found KIAA0090 to be upregulated in melanoma cells and nevi. Expression of EGFP-tagged proteins in mammalian cells showed
pronounced apoptotic cell death and involved alterations in mitochondria and ER. KIAA0090 knockdown also led to an increase of cell
death rates in melanoma cells. The endogenous protein was primarily localized either to mitochondria or Golgi, depending whether
the antibody used was to the N- or C-terminal regions. The results shown here corroborate many genetic interactions found in yeast,
but suggest that KIAA0090 protein has a broader subcellular localization and function than the one proposed for its yeast
counterpart. To decipher the role of this gene in development, we are beginning to conduct functional studies on the Drosophila
melanogaster KIAA0090 ortholog, CG2943. Driving an RNAi targeting CG2943 mRNA to skeletal muscle led to high rates of pupal
lethality and generated offsprings unable to fly and with severe deficiency of locomotion. Ultrastructural analyses of muscle fibers are
currently being performed to gain insights into the structural basis that accounts for the observed phenotype.
Financial Support: FAPESP, CNPq, DECIT, CAPES, FAEPA
Mitochondrial BER activities maintain mtDNA stability and mitochondrial function
Nadja Souza-Pinto
Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, SP, Brazil
The mammalian mitochondrial DNA (mtDNA) codes for 13 polypeptides, all essential components of the electron transfer chain.
Mutations and deletions of the mtDNA lead to mitochondrial dysfunction, which cause several human syndromes and have been
implicated in common, multi-factorial diseases such as cancer and neurodegeneration. The mtDNA is closely associated with the inner
mitochondrial membrane, where reactive oxygen species are generated as byproducts of normal oxidative metabolism. Thus,
mitochondria rely on DNA repair pathways to maintain mtDNA stability. Among those, the base excision repair has been extensively
characterized in mammalian mitochondrial. Mitochondrial BER (mtBER) involves 5 enzymatic steps, catalyzed by isoforms of the
enzymes involved in nuclear BER, which have been biochemically characterized. However, its regulation is still unclear. We
hypothesized that mtBER activity is modulated by proteins interactions, in a fashion akin to the modulation of nuclear BER. Using in
vitro assays to measure each BER step independently, we have identified two proteins which strongly affect mtBER activity. The
repair factor CSB (mutated in Cockayne Syndrome) is involved in maintaining mtBER activities anchored to the inner mitochondrial
membrane, where the mtDNA is located, and thus, favors mtDNA repair efficiency. On the other hand, the nucleoid protein TFAM
(Mitochondrial transcription factor A) binds to damaged DNA, diminishing the accesses of repair enzymes. TFAM binding to DNA is
modulated by p53, allowing the damage to be accessed by the BER enzymes. We propose a model in which CSB, TFAM, p53, and
others, yet unidentified proteins, modulate mtBER activity in response to stress.
Dietary interventions, mitochondria, oxidants and lifespan
Alicia J. Kowaltowski
Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, SP, Brazil
Mitochondrial energy metabolism and mitochondrially-derived oxidants have, for many years, been recognized as central toward the
effects of aging. Calorie restriction (CR) enhances animal lifespan and prevents age-related diseases, including neurological decline.
Recent evidence suggests a mechanism involved in CR-induced lifespan extension is NO●-stimulated mitochondrial biogenesis. We
examine here the effects of CR on brain mitochondrial content. CR increased eNOS and nNOS and the content of mitochondrial
proteins in the brain. We established an in vitro system to study the neurological effects of CR using serum extracted from animals on
this diet. In cultured neurons, CR serum enhanced nNOS expression and increased nitrite levels (a NO● product). CR serum also
enhanced the levels of cytochrome c oxidase and increased citrate synthase activity and respiratory rates. CR serum effects were
inhibited by L-NAME and mimicked by the NO● donor SNAP. Furthermore, both CR sera and SNAP were capable of improving
neuronal survival. Since eNOS is the main source of NO● involved in mitochondrial biogenesis, we investigated the mechanism of NOS
activation by treating vascular cells with serum from CR rats and found increased Akt and eNOS phosphorylation, in addition to
enhanced nitrite release. Inhibiting Akt phosphorylation or immunoprecipitating adiponectin (found in high quantities in CR serum)
completely prevented the increment in nitrite release and eNOS activation. Overall, we demonstrate that adiponectin in the serum
from CR animals increases NO• signaling by activating the insulin pathway, resulting in enhanced mitochondrial biogenesis and
neuronal survival.
Supported by FAPESP, CNPq and INCT/NAP Redoxoma
74
Symp#23 Cytotoxicity -Brazilian-Slovenian Meeting
Chairs Sandra Azevedo and Tamara Lah Turnsec
Tamara Lah Turnsec
Department of Genetic Toxicology and Cancer Biology, National Institute of Biology, Ljubljana, Slovenia.
Cancer initiation and promotion is caused by a number of substances of artificial as well as natural origin that perturb normal cell
metabolism and in the first case also effect gene structure and expression by direct or indirect effects on cell nuclei. Genetic
toxicology is the field that describes ad study such events and when these are initiated by environmentally released substances, the
ecotoxicology may explain its effect is origin, distribution and metabolism as well as the effects on different organisms, including
humans.
In this session all these are combined, leading us from ecotoxicology, associated with water organisms that release a number of
toxins into their environment. Being of structurally very diverse families and sizes (from small peptides of unusual structure, that
would not be degraded by host proteases (but rather inhibit them) to larger oligomeric protein structures forming pores in the cell
membranes. These toxic substances may have differential effects, both on the same and other species in their environment.
After overcoming the cell defence and resistance mechanisms, the toxins either cause autophagy, senescence or apoptosis via a
number of pathways, which may lead either to cell death or transformation, which primed the cells with the potency to tumour
progression. By the same token, a number of toxins are also being testing for their effect on eradicating cancer cells and recently
also cancer stem cells. The problem here, especially in the case of cancer stem cells. The latter in particular have developed a
number of resistance mechanisms. This being overcome by an appropriate combination of toxins with other strategies to specifically
attack cancer cells, offer new strategy in cancer treatment that may lead to improved efects at least in certain cancer strategies.
Also, as cancer tissue is composed of a variety of tumour and normal - stromal cells, the effects on these, as well as on their
interactions need to be considered in the future.
Cyclic cyanopeptides influence cytoskeleton organization in glial cells
Bojan Sedmak
National Institute of Biology, Ljubljana, Department of Genetic Toxicology and Cancer Biology, Večna pot 111, 1000 Ljubljana,
Slovenia, EU
Three basic ways of interaction are possible after cell exposure to biologically active substances; interaction with membrane
receptors, membrane insertion and cell entrance. The acute toxicity and cytotoxicity of the best known cyanopeptide microcystin
(MC) is primarily due to its ability to enter mammalian cells misusing the organic anion-transporting polypeptide system. Strong
protein phosphatase inhibitory activity is believed to be the mechanism by which MC destroys liver cells and consecutively the target
organ. In terms of genotoxicity brain cells suffer the most damage implying the possibility of MC passage through the blood brain
barrier. In addition to MCs bloom forming cyanobacteria produce a variety of other non-hepatotoxic cyclic cyanopeptides similar in
origin structure and activity in considerable amount.
Our experiments are focused to normal NHA and tumour derived U87 astrocytes to introduce cyanopeptides as research tools and
feasible lead substances in pharmacology. We have monitored the influence of cyclic cyanopeptides on both morphological and
genetic level. The effects on cell morphology were studied by pursuing the changes in intermediate filament (IF) organization. The
target were two IF’s, glial fibrillary protein expressed in many astrocyte cell lines and nestin expressed by many cell types during
development and does not persist into adulthood. Epifluorescent and confocal microscopy were used to pursue the morphological
changes while the expression of genes controlling the intracellular scaffolding’s biogenesis, organization, polymerization and
depolymerization of MF, MT, IF as well as the cytoskeletal regulatory genes, relevant ARF and RHO G-protein members and their
regulatory factors was assessed with RT2ProfilerTMPCR Array.
Equinatoxin effects on cellular membranes
1 Miša Mojca Cajnko, 1 Maja Marušič, 2 Biserka Bakrač, 1 Simon Caserman, 1,2 Gregor Anderluh
1 National Institute of Chemistry, Ljubljana, Slovenia
2 Department of Biology, Biotechnical Faculty, University of Ljubljana, Slovenia
Disruption of cellular membranes is a very efficient way to alter cellular function and, hence, pore-forming toxins are one of the most
important groups of natural toxins. The most studied pore forming toxins are bacterial virulence factors. Actinoporins are efficient
pore-forming toxins produced by sea anemones. They exclusively form pores in membranes that contain sphingomyelin. They are an
important example of so-called alpha-helical pore-forming toxins, since the final conductive pathway is formed by amphipatic alphahelices. The pore formation is a multistep process that involves recognition of the membrane sphingomyelin, firm binding to the
membrane accompanied with the transfer of the N-terminal region to the lipid-water interface and final pore formation after
oligomerization of several monomers. We have recently shown that equinatoxin II (EqtII), the most studied representative of
actinoporins, specifically binds SM, but not other lipids, and described molecular mechanism of SM recognition. By using EqtII as a
molecular probe we show that sphingomyelin in the Golgi apparatus is exposed to the cytosol of the cell. Due to its unique features,
EqtII was also used to study sphingomyelin distribution in the plasma membrane. EqtII binding was accompanied by extensive plasma
membrane reorganization into microscopic domains that resemble coalesced lipid rafts. Pore formation enabled entry of calcium ions
in the cell, which was followed in number of responses such as hydrolysis of phosphatidylinositol 4,5-bisphosphate, plasma
membrane blebbing, actin cytoskeleton reorganization, and inhibition of endocytosis. In Caco2 epithelial cells EqtII was found to
decrease transepithelial electrical resistance. It seems that plasma membrane reorganisation is, at least in part, a killing strategy of
actinoporins.
75
Symp#24 Cancer
Chair Renata Pasqualini
Integration of in Vivo Phage Display & Targeted nanotechnology and Molecular-genetic Imaging
Renata Pasqualini, Ph.D.
Our group has previously reported the design, generation, and construction of AAV/phage (termed AAVP) particles (Hajitou et al.
2006, Hajitou et al. 2007, Soghomonyan et al. 2007) for targeted molecular-genetic imaging. These hybrid vectors containing
prokaryotic and eukaryotic cis-genomic elements have the potential to integrate ligand-directed targeting and molecular-genetic
imaging. In a related line of research, we have used labeled, targeted peptide motifs themselves as imaging tools (Yao et al. 2005,
Marchiò et al. 2004, Arap et al. 2004, Zurita et al. 2004, Cardó-Vila et al. 2003, Chen et al. 2003, Mintz et al. 2003). In pilot
experiments, AAVP-based molecular-genetic imaging appears to be superior in side-by-side comparison to standard imaging because
it provides prediction of therapeutic response in addition to only monitoring (Hajitou et al., PNAS, 2008). Thus, we plan to focus
primarily on the development of AAVP-based molecular-genetic imaging approaches. Finally, we have also designed and developed
nanotechnology-based (i.e., bottom-up self-assembled) biocompatible networks of phage-gold as nano-molecular sensors and
reporters (Souza et al. 2006a, Souza et al. 2006b). This new methodology will be incorporated and will likely prove to be quite
synergistic with AAVP (Souza et al. 2011). Here we used prototypes of this new class of targeted hybrid vectors for therapy and for
molecular-genetic imaging, in conjunction to the discovery of new ligand motifs that target human tumor endothelium. AAVP-based
anti-vascular cancer therapy by targeted TNF in pet dogs with native tumors has also been successful (Paoloni et al. 2009). Ultimately
to generate an “imaging transcriptome” for human tumors. The incorporation of transcriptional targeting (through tissue-specific or
radiation-induced promoters) to ligand-directed AAVP-targeting may enable one to determine a gene (or set of genes) status without
tissue biopsy.
Tumor Cell to Tumor Cell Interaction Drives Cancer Heterogeneity
Webster K. Cavenee
Ludwig Institute for Cancer Research, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0660 USA
Most efforts to understand the consequences of large-scale genomic mining of data from human tumors have focused on their cellintrinsic activities both in vitro and in vivo. Because of this, targeted therapeutic approaches have primarily been directed at features
of individual tumor cells and their intrinsic mutations. For example, we have for more than a decade functionally dissected the
amplification and mutation of the epidermal growth factor receptor gene (EGFR), that results in the common and oncogenic EGFRvIII
(ΔEGFR) variant, a signature pathogenetic event in glioblastoma, the most common intracranial tumor. These analyses have allowed
us to develop both small molecule- and antibody-based therapeutics that are now in clinical trials.
Paradoxically, despite its greater intrinsic biological activity than wildtype EGFR (wtEGFR), only a minority of cancer cells in primary
tumors possesses the hallmark ΔEGFR lesion, while the remainder expresses wtEGFR. We hypothesized that the ΔEGFR-expressing
subpopulation has an extrinsic activity that provides enhanced tumorigenicity to the entire tumor cell population, perhaps through a
paracrine mechanism. Using a combination of mixed tumor engraftments and biochemical analysis of paracrine factors and signaling
pathways activation, we determined that human glioma tissues, glioma cell lines, glioma stem cells and primary mouse astrocytes,
that express ΔEGFR each secrete IL-6 and/or LIF cytokines. This then prompts a novel interaction between the receptor that is
common to these cytokines, gp130, and wtEGFR in neighboring cells that express amplified levels of EGFR, resulting in co-receptor
activation and tumor growth enhancement. Ablating IL-6, LIF or gp130 uncouples this cellular cross-talk and potently attenuates
tumor growth enhancement.
These findings demonstrate that the heterogeneity that characterizes GBM, and perhaps other tumors with this feature, does not
occur stochastically. Instead, it results from both intrinsic and extrinsic activities of driver mutations and can be an actively
maintained feature. This illuminates for the first time a heterotypic cancer cell interaction of potential therapeutic significance.
Targeting Adipose Tissue to Prevent Cancer Progression
Wadih Arap, M.D., Ph.D.
Human obesity is a leading cause of morbidity and mortality and a financial burden worldwide. Despite efforts in past decades, very
few drugs have been developed for the treatment of obese patients. The paradigm of obesity treatment currently relies on CNS
and/or peripheral metabolic mechanisms to suppress appetite and elevate energy expenditure, or inhibition of fat absorption. Only
two Food FDA-approved drugs for weight loss are currently available in the United States (phentermine and orlistat); most
unfortunately, placebo-subtracted weight losses are small and concerns over side effects limit their use, hence the great therapeutic
challenge. Here we evaluated and validated a new conceptual approach against obesity: targeted induction of apoptosis in blood
vessels supplying white adipose tissue (WAT). Our group is a pioneer in this area and has previously designed and has recently
established adipotide as a prototype in a new class of drugs that target the vascular endothelium of white fat in pre-clinical models of
obese rodents and obese non-human primates. We have chosen to pursue a pilot application of adipotide as a strategy to overcome
the obesity-related tumor-promoting effects of obesity in the context of human prostate cancer progression and recurrence.
Notably, we have received “safe-to-proceed status” from the FDA for the IND application of adipotide; as such, the start of the firstin-human clinical trial in obese prostate cancer patients is imminent. Our Specific Aims are: (i) To define the metabolic and oncologic
consequences of targeted treatment with adipotide in obese men with prostate cancer. (ii) To lead optimize adipotide derivatives
and dose-limiting toxicity in rodents and non-human primates. In the short-term, imaging guided studies will enable the rapid
translation and drug lead optimization of adipotide and will provide the clinical foundation for approval of an entirely new approach
against human obesity. In the long-term, a successful innovative therapy such as adipotide against human obesity would truly be
transformative with immense public health impact against not only obesity but also against associated patient co-morbidities
including diabetes, metabolic syndrome, arterial hypertension, atherosclerosis, and cancer.
76
Symp#25 Cell motility
Chair James Sellers
A Tale of Two Tails: The Regulation of Myosin-5a and Myosin-7a
James R. Sellers
National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892 USA
Myosins are a superfamily of molecular motors that can be subdivided into more than 35 classes. Myosins have
undergone structural and functional adaptations to perform many duties inside cells and in many cases the activity of
the myosin is tightly regulated. In this talk I will discuss the structure, function and regulation of two myosins, mouse
myosin-5a and Drosophila myosin-7a. Myosin-5a is a processive cargo transporter in cells which helps move organelles
from one point to another, whereas myosin-7a appears to be active in areas of very high actin density such as
stereocelia and other actin bundles. In humans, mutations in myosin-7a lead to deafness and blindness. The enzymatic
activities of both of these myosins are regulated in vitro through head-tail interactions, but the molecular details of
these interactions are very different. Myosin-5a is a dimeric motor and the presence of both heads is important to the
regulation, whereas myosin-7a is monomeric. Each myosin has at least one binding partner that is sufficient to activate
the myosin from its off state. For myosin-5a this binding partner is termed melanophilin which also interacts with
Rab27a to form a tripartite complex that connects the melanosome to actin filaments. We discovered a novel protein
in Drosophila that interacts with myosin-7a to activate its activity. The details of the regulation of these two myosins
will be discussed.
Single Molecule Fluorescence and Optical Trapping Applied to Molecular Motors: Two can do it better than one.
Paul Selvin
Mindy Tonks Hoffman, Ben H. Blehm, Paul R. Selvin, University of Illinois, Urbana-Champaign
Kinesin and dynein are molecular motors that move in opposite directions on a microtubule. They often act on the
same cargo, causing the cargo to frequently switch direction. Whether this back-and-forth motion results from a
coordinating complex or from a tug-of-war between the two motors is currently unknown. We have applied single
molecule fluorescence to determine that they are undergoing a synergistic tug-of-war. By synergistic, we mean that
the combination of the two motors is able to bypass roadblocks along the microtubule. Furthermore, using an in vivo
optical trap, and by comparing directional stall forces in vivo and in vitro, we found when cargo is going in the positive
microtubule direction, kinesin and dynein are pulling, with the dynein walking backwards. The net stall force equals
the stall force of kinesin (≈ 7 pN) minus the stall forces of the number of dyneins (1.1 pN x ND, where ND, = 0 to 6).
When moving in the negative microtubule direction, the stall force is just equal to a multiple of dynein’s stall force (1.1
pN x ND), implying that kinesin has fallen off the microtubule.
Microfluidics pushes forward microscopy analysis of actin dynamics
1
1
1
2
Marie-France Carlier , Antoine Jégou , Guillaume Romet-Lemonne , Thomas Niedermayer and Reinhard Lipowsky
1
Cytoskeleton Dynamics and Motility group, CNRS UPR 3280, 91198 Gif-sur-Yvette France
2
Theory and Biosystems, Max Planck Institute of Colloids and Interfaces, Potsdam Germany
2
Cycles of site-directed actin polymerization and depolymerization, associated with ATP hydolysis, drive a large number
of motile processes in eukaryotic cells. The study of actin dynamics and its control by regulatory proteins has mainly
relied, for 30 years, on bulk solution kinetic measurements in which the behavior of many filaments is averaged.
Recently, individual filament dynamics have been approached using Total Internal Reflection Fluorescence (TIRF)
microscopy. The latter method uniquely allows analysis of fluctuations in length of filaments or their processive
assembly by formins, but suffers from artifacts resulting from the need to immobilize filaments on a coverslip, the lack
of spatial and temporal resolution and tedious image analysis. To overcome these problems, we have implemented
microfluidics in the TIRF method. Two issues have been addressed at the scale of single filaments. First, by switching
rapidly filaments from polymerizing to depolymerizing conditions, analysis of nucleotide dependent disassembly rate
demonstrates that the slow release of Pi following rapid cleavage of ATP on a single filament assembling from ATP-Gactin occurs via a random mechanism. Second, we show that the reported abrupt switches to very slow filament
depolymerization, attributed to the structural stabilization of filaments upon ageing (Kue and Mitchison, PNAS 2008,
Science 2009) are actual pauses in depolymerization, caused by stochastic formation of photo-induced,
immunodetectable covalent actin dimers within the filaments. Statistic analysis of the frequency of pauses shows that
pauses represent the slow dissociation of actin dimers. Further developments of microfluidics in the study of actin
dynamics will be discussed.
77
Symp#26 RNA regulation - Canadian Society for Cell Biology
Chairs and speakers Jean Pierre Perrault and Carla Columbano
Impact of G-quadruplex structures on the human transcriptome
Jean-Pierre Perreault and Jean-Denis Beaudoin
Groupe ARN/RNA group, Département de biochimie, Faculté de médecine et des sciences de la santé, Université de Sherbrooke,
Sherbrooke, QC, J1H 5N4, Canada ([email protected])
Given that greater than 90% of the human genome is expressed, it is logical to assume that post-transcriptional regulatory
mechanisms must be the primary means of controlling the flow of information from mRNA to protein. Guanine-rich nucleic acid
sequences can fold into non-canonical, four stranded helical structures called G-quadruplexes. Initially, we have developped a robust
approach that includes in silico, in vitro and in cellulo experiments permitting an in-depth evaluation of the global impact of Gquadruplexes as translational repressors. Briefly, sequences including potential G-quadruplexes were selected within 9 distinct genes
encoding proteins involved in various biological processes. Six of these sequences were observed to fold into G-quadruplex structures
in vitro, all of which exhibited translational inhibition in cellulo when linked to a reporter gene. In addition, the impact of single
nucleotide polymorphism was shown to be important in the formation of G-quadruplexes located within the 5’-untranslated region of
an mRNA. Subsequently, the same approach was applied in order to study to evaluate the presence of G-quadruplex structures within
human 3'-UTRs. Specifically, two potential G-quadruplex sequences located in the 3'-UTR of the low density lipoprotein receptorrelated protein 5 (LRP5) gene and the fragile X mental retardation autosomal homolog 1 (FXR1) gene were chaarcterized. Both of
these G-quadruplex structures increases by 2-fold the gene expression of a reporter gene by stimulating the polyadenylation of its
mRNA throughout an alternative site located downstream of the canonical site of their corresponding 3'-UTR. Sequence analysis, site
directed mutagenesis, miRNA regulation network analysis and G-quadruplex ligand experiments were performed to define rules
governing this phenomenon. In light of these results, we suggest that 3'-UTR G-quadruplexes can regulate alternative polyadenylation
sites, leading to the expression of shorter transcripts, and can interfer with the miRNA regulatory network of a specific mRNA. In light
of these results, the G-quadruplexes represent a class of RNA motif that is broadly distributed in the cellular transcriptome and have
important impact on mRNA species.
Identification of proteins regulating the RNA exosome
Carla Columbano Oliveira
Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo
In eukaryotes, many posttranscriptional processing events are necessary for the synthesis of mature RNAs. mRNAs, tRNAs, rRNAs,
snRNAs and snoRNAs are processed through several steps that involve specific reactions between RNA and proteins. In fact, most
cellular RNAs are associated with proteins, forming ribonucleoprotein complexes (RNPs), which participate in different aspects of
gene expression.
The main focus of our laboratory has been the study of the posttranscriptional control of gene expression through the functional and
structural characterization of proteins that regulate processing of different types of RNA. We will show the identification and
functional characterization of Saccharomyces cerevisiae proteins that interact with and regulate the RNA exosome, a protein complex
involved in processing and degradation of all types of RNA. Nop53p and Nop8p are nucleolar proteins involved in the maturation of
the large ribosomal subunit and regulate the RNA exosome during this process in different ways. While Nop53p activates the
exosome, Nop8p inhibits it. These observations led to the hypothesis that the interactions between different proteins and the
exosome are responsible for directing the complex to its substrates, and for controlling its activity.
Inhibition of RNA Polymerase I as a Strategy to Treat Cancer
Megan J. Bywater1, Katherine M. Hannan1, Gretchen Poortinga1, Joanna C. Chan1, Elaine Sanij1, Nadine Hein1, Carleen Cullinane1,
Denis Drygin2, William G. Rice2, Ricky W. Johnstone1,3, Grant A. McArthur1,3, Ross D. Hannan1,3 and Richard B. Pearson1,3.
1
Division of Cancer Research, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Vic, Australia; 2Cylene
Pharmaceuticals Inc., 5820 Nancy Ridge Drive, San Diego, CA 92121, USA; 3Sir Peter MacCallum Department of Oncology, University
of Melbourne, Melbourne Australia.
Morphologic abnormalities of the nucleolus, the site of transcription of the ribosomal genes (rDNA) by RNA Polymerase I (Pol I), have
been recognized as diagnostic for cancer for more then a century. Furthermore, accelerated ribosome biogenesis is invariably
associated with malignant transformation. Nevertheless, a critical, unresolved question has been whether the accelerated ribosome
biogenesis responsible for the nucleolar changes is required for maintenance of the malignant phenotype.
Here we show that the PI3K/AKT pathway, deregulated in a high proportion of human tumours, is a critical regulator of ribosome
biogenesis. Constitutively active AKT is sufficient to drive rRNA synthesis, ribosome biogenesis and cell growth. Furthermore, AKT
cooperates with c-MYC to activate rRNA synthesis and ribosome biogenesis identifying the AKT/mTORC1/MYC network as a master
controller of cell growth. Consistent with this concept, AKT activity is required for maximal activation of rRNA synthesis and tumour
formation in the E-Myc mouse model of Burkitt’s lymphoma (1). Our findings raise the exciting possibility that malignant diseases
characterized by unrestrained cellular growth may be vulnerable to therapeutic strategies that target ribosome biogenesis.
To directly test this hypothesis, we used genetic manipulation and a novel selective small molecule inhibitor of Pol I transcription (CX5461) (2), to provide the first definitive evidence that accelerated rDNA transcription and nucleolar integrity are necessary for
oncogenic activity in hematologic tumour cells. Further, we show that Pol I transcription can be targeted in vivo to therapeutically
treat tumors in both genetically engineered and xenograft models of lymphoma and leukemia through the non-genotoxic activation
of p53-dependent apoptosis, while sparing normal cells of hematological lineages. Thus, selective inhibition of Pol I transcription, a so
called ‘”house keeping” process, can serve as a novel therapeutic strategy for the treatment of cancer (3).
(1) Chan J.C, et al (2011) Science Signaling 4 (188), ra56, (2) Drygin, D et al., (2011) Cancer Res, 71(4):1418-3
(3) Bywater, M.J. et al (2012) Cancer Cell (accepted for publication)
78
Symp#27 Maternal interface
Chair Estela Bevilacqua
Felipe Vadillo-Ortega
Universidad Nacional de Mexico (UNAM), Mexico
The placenta as an early marker of genomic, proteomic and epigenetic changes involved in vascular diseases
Paola Casanello, Krause B, Caniuguir A, Muñoz E, Carrasco I.
Faculty of Medicine Pontificia Universidad Católica de Chile
Fetal programming resulting from disturbed intrauterine growth induces permanent physiological alterations that
increase the risk of developing cardiometabolic diseases in the adulthood. Most of the support for this notion has
come from animal models, and correlations between neonatal data and adult health in humans. Interestingly, human
placenta seems to represent a good source for the study of this process. There is convincing data showing that
macroscopic placental characteristics as well as molecular and epigenetic markers in the placenta at term predict adult
cardiometabolic risk. We have studied the effect of hypoxia on vascular function and endothelial physiology in
placentae from intrauterine growth restriction (IUGR) fetuses. These studies have shown that endothelial cells from
IUGR placentae (IUGR-EC) present altered expression patterns at transcriptional and proteomic levels, similar to those
observed in normal EC exposed to hypoxia, confirmed the idea that endothelial dysfunction can be programmed in
utero In fact, IUGR-EC present altered expression of eNOS, CAT-1 and arginase-2, which correlate with altered NOSdependent vascular relaxation. Moreover, the altered expression of eNOS in IUGR-EC is associated to specific changes
in the DNA methylation status at NOS3 promoter. Interestingly, eNOS expression in IUGR-EC can be reprogrammed
preventing the heritance of DNA-methylation patterns by transient silencing of DNMT1. All these data highlight the
applicability of placental studies in order to predict future health risk in humans, however further efforts are necessary
to validate the implications of these seminal findings and how these could represent the vascular alterations that take
place in the fetus.
Supported by FONDECYT-1120928, CONICYT Anillos ACT-73, AT24100107(Chile). EM & BK hold CONICYT PhD grants.
Expression and function of PSG, StarD7 and KLF6 genes in human trophoblast cells
Graciela M Panzetta-Dutari., Racca AC., Camolotto S., Ridano ME., Flores-Martin J., Rena V. & Genti-Raimondi S.
CIBICI-CONICET. Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas. Universidad Nacional de
Córdoba. Ciudad Universitaria. Córdoba. Argentina.
Placenta is intimately related to fetal and maternal health. Villous cytrophoblasts (CTB) differentiate by fusion to form
the syncytiotrophoblast (STB) layer characterized by a high metabolic and biosynthetic activity. Human pregnancyspecific glycoproteins (PSG) are the major STB secreted proteins at term, and low PSG levels have been associated with
complicated pregnancies. Steroidogenic acute regulatory protein-related lipid transfer domain containing 7 (StarD7)
has a wide-spread expression in trophoblastic tissues with highest levels in choriocarcinoma cells, and KLF6 knockout
mice exhibit impaired placental development. In order to further elucidate gene expression control and function of
these proteins in placental biology, we performed microscopy, qRT-PCR, western-blot, transfection, siRNA, DNAprotein interaction and immunoprecipitation assays, among others, in human trofoblastic cell models. We found that
PSGs are early differentiation markers whose expression precedes that of hCG and cell fusion. PSG promoter
activation involves regulation by Sp1, KLF6, acetylation/ deacetylation balance and 5`proximal sequences. Remarkably,
KLF6 peaks early during the syncytialization process, transactivates PSG and hCG genes, and KLF6 down-regulation
inhibits CTB fusion, suggesting it is an essential regulator of trophoblast differentiation. StarD7 expression is regulated
by SF-1 and Wnt--catenin signaling which might have important implications in phospholipid uptake and transport
contributing to trophoblast development. Finally, as an increased risk of pregnancy alterations has been reported in
women chronically exposed to pesticides, we investigated chlorpyrifos effect on trophoblast cells. Exposures to
concentrations which did not alter cell viability and fusion modified KLF6, hCG, GCM1, ABCG2, and P-gp but not PSG
and StarD7 gene expression. These studies have provided a better understanding about the molecular players involved
in trophoblast cell biology and hence in pregnancy maintenance. This study was conducted with the ethics approval
from the Human Studies Local Committee. It was supported by CONICET, FONCyT, MinCyT of Córdoba and SECyT-UNC
Listing of authors Panzetta-Dutari GM., [email protected]; Racca AC., [email protected]; Camolotto S.,
[email protected]; Ridano ME., [email protected]; Flores-Martin J., [email protected]; Rena V.,
[email protected]; Genti-Raimondi S., [email protected]
Haya de la Torre y Medina Allende. Ciudad Universitaria. X5000HUA Córdoba, Argentina,
79
Symp #28 Cells as biosensors
Chairs Glaucia M Machado Santelli and Paulo Saldiva
Cytotoxic indole alkaloids isolated from Duroia macrophylla (Rubiaceae).
Cecilia Veronica Nunez1*, Marne Carvalho de Vasconcellos2, Vincent Roumy3, Sevser Sahpaz3, François Bailleul3, Thierry Hennebelle3.
1
Laboratório de Bioprospecção e Biotecnologia, Coordenação de Tecnologia e Inovação, Instituto Nacional de Pesquisas da Amazônia,
Aleixo, Manaus, Amazonas, 69060-001, Brazil;
2
Faculdade de Ciências Farmacêuticas, Universidade Federal do Amazonas – UFAM, Rua Alexandre Amorim, 330, Aparecida, Manaus,
Amazonas, 69010-330, Brazil;
3
Laboratoire de Pharmacognosie, EA 4481, Université de Lille 2 – Droit e Santé, 59006, Lille, France.
Duroia macrophylla Huber is a native plant species of the Amazon region. It is known as cabeça-de-urubú, apuruí or puruí-grande-damata but no medicinal use is described for it. In our research group bioprospection programm, we collected several Rubiaceae plant
species, prepare organic and aqueous extracts and assayed to several activities. D. macrophylla extracts were first assayed against
Artemia salina, to determine their toxicity. The methanolic leaf extracts was toxic against A. salina, with a LD50 of 40.00 µg/mL. Then,
the methanolic leaf extract was fractionated and 4 alkaloids were isolated: two new roxburguine indole alkaloids plus two other
known ones. All isolated substances were essayed on tumor cell lines and the new alkaloid 4 showed a cytotoxic activity against HL60
(human leukemia), APC02 (human gastric adenocarcinoma) and B16F10 (murine melanoma) tumor cell lines (IC 50 values of 2.28
µg/mL, 5.08 µg/mL and 5.11 µg/mL, respectively) and a cytotoxicity of 7.8 µg/mL on normal cell line NHI3T3 (fibroblast murine). The
alkaloids assayed did not cause membrane disruption in mouse erythrocytes. This is the first chemical study on this species. Our
findings showed that Amazonian plant species can contain new active substances, even if they do not have popular use.
Acknowledgments: CT-Agro/CNPq, PPBio/CNPq, FAPEAM, INCT - CENBAM/CNPq.
Cell-fiber interactions: effects on cell biology
Glaucia Maria Machado-Santelli
([email protected]) Department of Cell and Developmental Biology Institute of Biomedical Sciences - University of São Paulo,
Brazil
Particle toxicology main subject is to understand their cytotoxic and genotoxic mechanisms. Initial studies focused on the evaluation
of particles parameters after inhalation such as the diameter, length and biopersistence led to the association of asbestos exposure
with several health problems including lung cancer and mesothelioma. The low biopersistence of chrysotile, causing it to disintegrate
and become shorter in the lungs, is the main structural features that lead the chrysotile being less pathogenic than the amphiboles.
This safety has been controversial since in vitro chrysotile-associated genotoxic potential has been demonstrated. We evaluated the
induction of micronucleated, poliploid and multinucleated cells in chrysotile exposed cultured cells. These in vitro studies show that
fibers interfere with mitoses and cytokinesis progression leading to multinucleated and polyploid cells. Cell cycle progression is
impaired by fibers and multipolar mitosis may be consequence of fiber induced centrosomic amplification. The cell fate was followed
by pulse-time microscopy, allowing us to establish how the chrysotile treatment acts on cell cycle progression and its possible
relation with other types of fibers.
Cellular responses to ambient levels of air pollution
Paulo Saldiva
([email protected]) Department of Pathology Faculty of Medicine – University of São Paulo, Brazil
The widespread use of fossil fuels has been associated to marked alterations in our environmental. Global climate changes and local
air pollutants are known to cause adverse health effects in humans. The use of cells as biosensors of adverse effects have provided
valuable information for the process of evaluating environmental risk associated to air pollution. Respiratory epithelium,
endothelium, placental trophoblast, cells of seminiferous tubules, endometrium, and cells of reproductive organs of higher plants
have been extensively used to detect, quantify and explore the mechanisms of pollution induced injury, disclosing new perspectives
to the process of pollution control, aimed to preserve human health. Effects of air contaminants such as endocrine disruption,
cardiovascular damage, cancer induction and promotion and persistent inflammation, have been characterized using cellular systems
or in vivo toxicological approaches. In this context, biomonitoring of air pollution is nowadays as important as the classical chemical
characterization of the concentration of environmental toxics, opening new areas of research in cell biology.
80
Symp#29 MMPs and TIMPs
Chairs Ruy Jaeger
Membrane Type I- Matrix Metalloproteinase (MMP14): A Multifaceted Cell Surface Protease in Cancer
Stanley Zucker
MMP14, an intrinsic plasma membrane proteinase, plays a critical role in digesting basement membrane and
extracellular matrices and in inducing cancer cell migration, thereby promoting cancer invasion and metastasis. We
and others have demonstrated that MMP14 is highly expressed in most human cancers and correlates with poor
clinical outcome. We have evaluated the role of MMP14 in converting quiescent tumor initiating cells (TICs) to
metastatic cancer cells. Our studies of the hemopexin (PEX) domain of MMP14 have shown that of the 4 outermost
blades, strands I and IV are essential fo cell migration. Peptides mimicking these outermost strands reduced cancer
cell migration and angiogenesis in vitro and lung metastasis in vivo. We next examined the effect of cellular hypoxia on
MMP14 function in TICs. SK-3rd TICs, isolated by passage of human breast cancer cells in immunodeficient mice,
display enhanced lung metastases. Surprisingly, under normoxic conditions, SK-3rd cells displayed minimal increase in
cancer invasion. However, when cultured under hypoxic conditions, a dramatic increase in cell invasiveness in 3D
collagen gels was demonstrated, which coincided with increased localization of MMP14 at the cell surface. These data
suggest that induction of TIC invasion during hypoxia is caused by enhanced trafficking of MMP14 from the trans Golgi
network to the plasma membrane. MMP14 also induces the generation of reactive oxygen species in cancer cells,
leading to enhanced cancer aggressiveness. Our most recent studies incriminated tumor growth factor-beta as a key
intermediary in MMP14 cell signaling in cancer progression.
Rama Khokha
University Western Ontario, Toronto, Canada
Role of matrix metalloproteinases and inflammasome pathway in the development of airway inflammation and
fibrosis
Vincent Lagente
UMR991 INSERM/Université de Rennes 1, Faculté de Pharmacie,
2 avenue du Prof Léon Bernard, 35043 Rennes cedex, France
Matrix metalloproteinases (MMPs) are a major group of proteases known to regulate the turn-over of extracellular
matrix and so they are suggested to be important in the process of lung disease associated with tissue remodelling.
Pulmonary fibrosis has an aggressive course and is usually fatal for an average of three to six years after the onset of
symptoms. Pulmonary fibrosis is associated with deposition of extracellular matrix (ECM) components mainly collagen
in the lung interstitium. The excessive airway remodeling as a result of an imbalance in the equilibrium of the normal
processes of synthesis and degradation of extracellular matrix components could be in favor of anti-protease
treatments. We previously demonstrated a significant inhibition of bleomycin-induced pulmonary fibrosis in mice by
the MMP inhibitor batimastat. We also reported a correlation of the differences in collagen deposition in the lungs of
bleomycin-treated mice with a reduced molar pro-MMP-9/TIMP-1 ratio in broncholaveolar lavage fluid, beginning as
early as the inflammatory events at day 1 after bleomycin administration. The differences in TIMP-1 level, particularly
at early events after bleomycin administration, suggest that early altered regulation of matrix turnover may be
involved in the further development of bleomycin-induced pulmonary fibrosis. We also demonstrated that
Inflammasome-NLRP3 pathway associated with the IL-1R/MyD88 signaling is required in the bleomycin-induced
increased TIMP-1 level and pulmonary fibrosis in mice. Finally, these observations emphasize those effective therapies
for these disorders must be given early in the natural history of the disease, prior to the development of tissue
remodeling and fibrosis.
81
Symp #30 Telomeres
Chair Maria Isabel Cano
Saccharomyces cerevisiae as a model for the study of telomere-mediated replicative senescence
Maria Teresa Teixeira
Emilie Fallet, Pascale Jolivet, Julien Soudet, Zhou Xu, Kamar Serhal and Maria Teresa Teixeira
Institut de Biologie Physico-Chimique, FRE3354 CNRS/UPMC Biologie Moléculaire et Cellulaire des Eucaryotes - 13 rue
Pierre et Marie Curie, 75005 Paris, France ; ERC-STG-2010 D-END
In the absence of telomere length maintenance, telomeres shorten progressively with every replication cycle due to
the DNA-end replication problem. This leads to a permanent cell cycle arrest called replicative senescence. In humans,
this process is involved in the aging of certain organs and in suppression of cancer. Telomeres can be re-elongated by
telomerase or more rarely by homologous recombination (HR) in cells that proliferate indefinitely such as unicellular
eukaryotes, stem cells and cancer cells of multicellular eukaryotes. In telomerase-deficient yeast cells, replicative
senescence is defined as an arrest in G2/M after 60-80 generations as telomeres shorten 2-4 nt/cell division. Our
analysis of the DNA-end replication problem formally demonstrate that telomere shortening occurs during the
synthesis of the leading strand and depends on the length of the 3’-protruding end of chromosomes. Together with
the study of factors that regulate the resection and the synthesis of the 5’ strand, our data support a precise molecular
model of the DNA replication of telomeres. Senescence in yeast depends on the DNA damage checkpoints, similar to
other eukaryotes. A mathematical modeling of the distribution of telomere length and analysis of meiotic products
suggests that the shortest telomere in a cell may have a determinant role in the onset of senescence. Accordingly, the
DNA damage checkpoints recognize a very short telomere in senescent cells, triggering a replication fork regression
and sister chromatid HR. We propose that these pathways counteract the telomere shortening rate allowing a few
additional cell divisions before definitive arrest
Telomere dysfunction in human disease
Rodrigo Calado
University of São Paulo, Ribeirão Preto, Brazil
Telomeres and telomere repair are basic molecular features of cells possessing linear DNA chromosomes and defects
in them result in various diseases. Severe deficiencies result in dyskeratosis congenita, a congenital aplastic anemia
with associated mucocutaneous abnormalities. Mutations in TERT, the catalytic component, and TERC, the RNA
template, can behave as risk factors for the development of bone marrow failure, pulmonary fibrosis, and hepatic
cirrhosis. Both penetrance and organ specificity are variable and not well understood. Chromosome instability is a
result of critical shortening of telomeres and cancer.
Searching for a CST-like complex at Leishmania spp. telomeres
Maria Isabel Cano
Instituto de Biociências, Depto. de Genética, UNESP-Botucatu, São Paulo-Brazil, 18618-970, [email protected]
In most eukaryotes telomere binding proteins play crucial roles by interacting with several other regulators to ensure
proper telomere maintenance and to form high order complexes. The CST complex, mainly formed by RPA-like
proteins, is being considered a second telomere capping mode occurring from budding yeast to higher eukaryotes.
The role of CST in chromosome-end protection couples the conventional replication machinery and telomere
functions and highlights the complexity of the end- protection process. Leishmania spp. telomeres are composed by
TTAGGG repeats which are maintained by telomerase. The basic Leishmania telomeric complex is formed by the
proteins RPA-1 and Rbp38, which bind in vitro and in vivo, with high affinity to the G-rich telomeric strand, and by the
TRF orthologue representing a shelterin component of this protozoan. Using a large scale search on the tri-tryps
database we were able to confirm that the Leishmania spp. genome, like other trypanosomatids, lacks all of the
conserved telomere-end-binding proteins found in other eukaryotes, such as the key components of the CST (e.g.
CDC13 and CTC) and the shelterin (POT1) complexes. Thus, we speculate that the Leishmania RPA-1 homologue may
play the same roles as POT1/CDC13 at parasite telomeres. In this report we used different approaches to show that
RPA-1 interacts with both Rbp38 and with telomerase. And also that the putative Leishmania CST-like complex meets
the TRF orthologue by physical interactions between Rbp38 and TRF. We speculate whether these protein interactions
reflect the entire telomeric complex or the presence of functionally distinct subcomplexes at parasite telomeres.
Supported by: FAPESP, CNPq
82
Symp#31 Cancer Stemness -Taiwan Cell Biology Society
Chair Ken Wu
Tariq Enver
Stem Cell Laboratory, UCL Cancer Institute, University College London, London, UK
Relapses after therapy-induced complete clinical remissions remain the most significant challenge in cancer therapy. This suggests
that a proportion of cancer cells at presentation, escape therapy and persist during remission. These cells presumably are the source
of relapse. Why are these cells chemoresistant? We argue that the answer lies in a combination of genetic and epigenetic
heterogeneity acting to some degree at the level of 'cancer stem' or 'tumour propagating' cells. We have obtained evidence in
support of this conceptual framework for cancer resistance in the context or childhood ALL, the commonest cancer of children. Our
results encourage a re-positioning of the cancer stem cell concept as it relates to disease in patients.
SOX2 promotes lung cancer stemness by inducing EGFR and BCL2L1 expression
Cheng-Wen Wu
Institute of Biomedical Sciences, Academia Sinica; and Program in Molecular Medicine, National Yang-Ming University, Taipei,
Taiwan, ROC.
Tumor cells have long been observed to share several biological characteristics with normal stem/progenitor cells; however, the
molecular mechanisms eliciting cancer stemness features in tumors remain elusive. SOX2 is a key regulator for maintaining stemness
properties in lung progenitor cells. Here we report the discovery and involvement of SOX2 in the development of lung cancer
stemness. SOX2 expression was associated with poor prognosis of lung cancer patients. SOX2 was expressed in a subclass of lung
cancer cells, the self-renewal and proliferation of which was dependent on SOX2 signaling. SOX2 induced EGFR expression via binding
to the EGFR promoter, and EGFR activation further upregulated SOX2 levels, forming a positive feedback loop. SOX2 overexpression
promoted chemoresistance, and SOX2 silencing perturbed mitochondrial integrity with marked apoptosis and autophagy. SOX2
induced BCL2L1 expression through binding its promoter. Ectopic BCL2L1 expression rescued SOX2 silencing–induced apoptosis,
autophagy, and mitochondrial abnormality. SOX2 overexpression induced tumor formation, and SOX2 knockdown attenuated tumor
growth in a xenograft mouse model. SOX2, EGFR and BCL2L1 expression was significantly correlated in primary lung tumors. These
data support the critical role of SOX2 in the development of lung cancer stemness via activation of EGFR and BCL2L1 signaling .
TBA
83
Symp#32 Unconventional organelles
Chair Marlene Benchimol
Reductive evolution and the minimal mitochondria of microsporidian parasites
Martin Embley
Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University, UK NE24HH
Microsporidians are important human pathogens causing chronic diarrhoea in children and the elderly, and infecting
immunocompromised patients, including those with HIV/AIDS. In addition to their medical importance, microsporidians have
become models for understanding cellular and genomic reduction in eukaryotes. The adoption of an obligate intracellular lifestyle
has allowed them to lose metabolic pathways and to simplify the structures and functions of cellular organelles. In my talk I will
discuss how such reductive evolution has affected the proteome and functions of their minimal mitochondria – now widely referred
to as mitosomes, and why, despite their reduced nature mitosomes are still essential for parasite viability.
An unconventional organelle: the hydrogenosome
Marlene Benchimol
Universidade Santa Úrsula, Laboratório de Ultraestrutura Celular - Rio de Janeiro - Brazil
Hydrogenosomes are spherical or slightly elongated organelles found in non-mitochondrial organisms. Like mitochondria
hydrogenosomes: (1) are surrounded by two closely apposed membranes and present a granular matrix: (2) divide in three different
ways: segmentation, partition and the heart form; (3) they may divide at any phase of the cell cycle; (4) produce ATP; (5) participate
in the metabolism of pyruvate formed during glycolysis; (6) present a relationship with the endoplasmic reticulum; (7) incorporate
calcium; (8) import proteins post-translationally; (9) present cardiolipin. However, there are differences, such as: (1) absence of
genetic material, at least in trichomonas; (2) lack a respiratory chain and cytochromes; (3) absence of the F0- F1 ATPase; (4) absence of
the tricarboxylic acid cycle; (5) lack of oxidative phosphorylation; (6) presence of peripheral vesicles. Hydrogenosomes are considered
an excellent drug target since their metabolic pathway is distinct from those found in mitochondria and thus medicines directed to
these organelles will probably not affect the host-cell. The main drug used against trichomonads is metronidazole, although other
drugs such as β-Lapachone, colchicine, Taxol, nocodazole, griseofulvin, cytochalasins, hydroxyurea, among others, have been used in
trichomonad studies, showing: (1) flagella internalization forming pseudocyst; (2) dysfunctional hydrogenosomes; (3)
hydrogenosomes with abnormal sizes and shapes and with an electron dense deposit called nucleoid; (4) intense autophagy in which
hydrogenosomes are removed and further digested in lysosomes.
Dynamic control of the contractile vacuole complex and acidocalcisomes and their functional role in the mechanisms of regulatory
volume decrease in Trypanosomatid parasites
Kildare Miranda1
Wendell Girard-Dias1, Wanderley de Souza1 and Roberto Docampo2 , 1Biophysics Institute, Federal University of Rio de Janeiro, 2
University of Georgia
Understanding mechanisms involved in osmoregulation control in protozoan parasites has been a challenge for many research
groups. Among these mechanisms, a cyclic AMP (cAMP) signaling pathway has been shown to play a key role in osmoregulation,
through a mechanism that involves the activation of an unusual organelle named the contractile vacuole complex (CVC). In
Trypanosoma cruzi, the CVC is formed by a central vacuole surrounded by interconnected tubules that undergo dynamic changes
upon osmotic stress and interacts with acidocalcisomes, whose structural organization, chemical properties and physiological activity
may also vary upon events of osmotic stress. Biochemical and molecular data have shown that the sequence of events that take
place in cells submitted to hyposmotic stress leads to an increase in cAMP levels, stimulating the traffic of an aquaporin from
acidocalcisomes to the CVC through a fusion mechanism. Acidocalcisomes contain basic amino acids and high levels of cations and
polyphosphate, a content that once released within the contractile vacuole, leads to an increase in the osmotic pressure towards the
lumen of the organelle, stimulating water transport into the CVC. Functional analysis of mutant parasites that overexpress enzymes
involved in the control of cAMP levels showed alterations in the regulatory volume decrease (RVD), a large and functional CVC and
were more efficient in volume recovery. Taken together, our data show dynamic changes in the osmoregulatory system of T. cruzi,
governed by signaling events that involve a unique mechanism of interaction of the CVC with acidocalcisomal components.
Cell biology of magnetotactic bacteria and their organelles: the magnetosomes
Ulysses Lins
Instituto de Microbiologia, UFRJ, Centro de Ciências da Saúde, Bloco I, Avenida Carlos Chagas Filho, 373 - 21941-902, Rio de Janeiro,
RJ, Brasil
Historically prokaryotes have been described as simple cells with organization principles distantly related to the more complex
eukaryotic cells. Recent advances in understanding the cell biology and molecular mechanisms underlying the ultrastructural
organization of bacterial cells have modified the traditional views used to distinguish eukaryotic from prokaryotic cells. The
complexity of prokaryotic cells and their similarities to eukaryotes is highlighted by the discovery of cytoskeleton elements in bacteria
and further by the description of membranous organelles with specialized functions in a number of prokaryotic species. One of these
organelles, the magnetosome, consists of a nanometer-sized magnetic crystal which is formed in the bacterial cell cytoplasm inside a
bilayer lipid vesicle containing a unique set of proteins. The magnetosomes are organized as chains within the cell and are
surrounded by a distinct cytoskeletal network of filaments. Bacteria that produce magnetosomes are called magnetotactic bacteria
because of their ability to orientate and navigate along magnetic field lines which is a consequence of the magnetic moment
generated by the chains of magnetosomes. The specific proteins expressed by the cell in the magnetosome membrane modulate the
biomineralization of the magnetic crystals within the magnetosome vesicle. Consequently, the controlled biomineralization process
that takes place in magnetosomes produce magnetic crystals with unique morphologies that is dependent on the magnetotactic
bacterial species.
84
Poster Sessions
July 26th (Thursday)
Cell Biology
Cell Biology and Inflammation
Cell Biology in Education
Cell Cycle and Proliferation
Cell Differentiation
Cell Therapy
Cells as Biosensors
Cytoskeleton
Developmental Biology
Epigenetics
Gene Therapy
Host Parasite Interaction
Methods in Cell Biology
Plant Cell Biology
Plasma Membrane and Organelles
Proteolysis
Stem Cells
Board ID
A1-A122
C1-C118
E1-E12
F-1-F27
H1-H19
K1-K16
L1-L7
M1-M13
N1-N51
O1-O18
Q1-Q5
R1-R75
S1-S30
U1-U41
V1-V10
X1-X10
Z1-Z42
Floor
1
1
2
2
1
2
2
2
2
2
2
2
1
2
1
2
2
July 27th (Friday)
Cell Biology and Cancer
Cell Biology and Reproduction
Cell Death
Cell Migration
Cell Signaling
Extracellular Matrix
Neurobiology
Board ID
B1-B252
D1-D140
G1-G39
I1-I13
J1-J48
P1-P37
T1-T85
Floor
1
2
2
2
1
2
2
85
Presentation guidelines
Poster Sessions will be held at 1st and 2nd floors (Room 203) and will be organized according
to the different areas. Please check your Board ID above.
Poster Session I: Thursday, July 26th
Set up: Wednesday 15h00- 17h00 and Thursday 9h00- 9h30
Tear down: until 15h30
Poster Session II: Friday, July 27th
Set up: Thursday 16h30 -18h00 and Friday 9h00- 9h30
Tear down: 16h00- 16h30
Author presentation hour for both sessions:
11h45- 12h45 even numbers
12h45-13h45- odd numbers
Poster numbers will identify the boards. Tapes and hangers should be brought to the area
by presenters. The Organizing Committee will not provide these items and will not collect
and keep Posters that are left on the Boards.
We will invite our speakers to select and nominate three best posters according to their
expertise. Winners and prizes will be announced during the closing cerimony
86
A – Cell Biology
A1-A122
A-1
EARLY WEANING AFFECTS CORTICOSTERONE LEVELS, CBG
BINDING CAPACITY AND GLUCOCORTICOID RECEPTOR IN THE GASTRIC MUCOSA
OF RATS DURING POSTNATAL DEVELOPMENT. HELOISA GHIZONI, PRISCILA
MOREIRA FIGUEIREDO, MARIE-PIERRE MOISAN, LUCIANA HARUMI OSAKI, CRUZ
ALBERTO MENDOZA RIGONATI, PATRÍCIA GAMA
A-2
NORMAL AND REGENERATION BONE TISSUE ANALYSIS: USE OF
FOURIER TRANSFORMED SPECTROSCOPY INFRARED (FTIR) FOR IN SITU
MOLECULAR IDENTIFICATION. TACIANA D. MAGRINI, HERCULANO S. MARTINHO,
ANA AMÉLIA RODRIGUES, NILZA BATISTA, WILLIAM D. BELANGERO, ARNALDO R.
SANTOS JR
A-3
A NOVEL LEISHMANIA AMAZONENSIS PROTEIN WICH INTERACTS
HIGHLY SPECIFICALLY WITH THE G-RICH TELOMERIC STRAND. VINICIUS SANTANA
NUNES, MARIBEL FERNÁNDEZ FERNÁNDEZ, CRISTINA BRAGA DE BRITO LIRA,
MARIA ISABEL NOGUEIRA CANO
A-4
AN EVALUATION OF CHONDROCYTES MORPHOLOGY AND GENE
EXPRESSION ON SUPERHYDROPHILIC VERTICALLY-ALIGNED MULTI-WALLED
CARBON NANOTUBES FILMS. ELIANE ANTONIOLI, ANDERSON O. LOBO, DANIELLA
Z. BUCCI, MARIO FERRETTI, MOISÉS COHEN, EVALDO J. CORAT, VLADIMIR J.
TRAVA-AIROLDI
A-5
ALTERED EXPRESSION OF LEPTIN AND GHRELIN IN THYMUS OF
ALOXAN-INDUCED DIABETIC MICE. CAROLINA FRANCELIN, IEDA GENISELI, LIANA
VERINAUD
A-6
ANALYSIS OF WNT PATHWAY COMPONENTS IN AN
EXPERIMENTAL MODEL OF ENDOMETRIOSIS. RÔMULO MEDINA DE MATTOS,
PAULA RODRIGUES PEREIRA, FÁBIO HECHT CASTRO MEDEIROS, DENISE PIRES DE
CARVALHO, LUCIANA BUENO FERREIRA, ETEL RODRIGUES PEREIRA GIMBA, FELIPE
LEITE DE OLIVEIRA, LEANDRO MIRANDA ALVES, LUIZ EURICO NASCIUTTI
A-7
INFLUENCE OF BIOMODULATION IN CELL CULTURE GIRARDIA
TIGRINA (PLATYHELMINTHES, TRICLADIDA). KARLA ANDRESSA RUIZ LOPES,
ROBERTA CARICATTO BERNARDO PINTO, NÁDIA MARIA RODRIGUES DE CAMPOS
VELHO, CRISTINA PACHECO SOARES
A-8
ACTION OF SULFATED GALACTANS FROM RED ALGAE HYPNEA
MUSCIFORMIS ON HEMOSTASIS, CELL PROLIFERATION AND CYCLE CELL
PROGRESSION. MONIQUE GABRIELA DAS CHAGAS FAUSTINO ALVES, CELINA
MARIA PINTO GUERRA DORE, KAHENA DE QUEVEDO FLORENTIN, LUIZA S.E.P.
WILL, THUANE DE SOUZA PINHEIRO, HUGO ALEXANDRE DE OLIVEIRA ROCHA,
EDDA LISBOA LEITE
A-9
EFFECT OF RESISTANCE TRAINING ON BLOOD PRESSURE, ARTERIAL
MORPHOLOGY AND VEGF PROTEIN EXPRESSION ON L-NAME HYPERTENSIVE
RATS. ANNE CAROLLINE VERÍSSIMO DOS SANTOS, AYSLAN JORGE SANTOS DE
ARAUJO, KARINE DOS SANTOS SOUZA, MARLÚCIA BASTOS AIRES, EMERSON
TICONA FIORETTO, VALTER JOVINIANO DE SANTANA-FILHO, MARCIO ROBERTO
VIANA DOS SANTOS
A - 10
INTERACTION CELL-CHRYSOTILE IN TWO DIFFERENT CELL LINES: A
MORPHOLOGICAL APPROACH. LUANA RIBEIRO RICARDI, BEATRIZ DE ARAUJO
CORTEZ, PAULA REZENDE-TEIXEIRA, GLÁUCIA MARIA MACHADO-SANTELLI
A - 11
α-A2BP1 MARKS P-BODIES CONTAINING REPRESSOR/DECCAPING
MRNP COMPLEXES DEVOID OF GW182 IN DROSOPHILA S2 CELLS. GUSTAVO
BORGES PEREIRA, MARIANA SANTOS DE QUEIROZ, DEISE CRISTINA POLETO
SCAGLIA, MARIA LUISA PAÇÓ-LARSON
A - 12
NITRIC OXIDE PRODUCTION BY ASCIDIAN HEMOCYTES AFTER
HEAVY METALS EXPOSURE. DANIELLY DA FONTE CARVALHO MARTINS, LAURA
CARRIELLO EMRICH, SILVANA ALLODI, RODRIGO NUNES DA FONSECA, CINTIA
MONTEIRO DE BARROS
A - 13
GILL NA+/K+-ATPASE ACTIVITY AND HISTOLOGICAL CHANGES OF
FISH BATHYGOBIUS SOPORATOR (GOBIIDAE) DURING ACCLIMATION TO
DIFFERENT SALINITIES AND TIMES. CLÁUDIO A. PIECHNIK, LUCÉLIA DONATTI,
MARIA ROSA D. PEDREIRO, PRISCILA KREBSBACH, HELENA G. KAWALL
A - 14
DECREASE OF THE ATAXIN-2 LEVELS SPECIFICALLY IN THE FAT
BODY INTERFERES WITH GROWTH AND SURVIVAL OF DROSOPHILA. MURILO
CARLOS BIZAM VIANNA, DEISE CRISTINA POLETO, PAULA FERNANDA GOMES,
MARIA LUISA PAÇÓ-LARSON
A - 15
DROSOPHILA ATAXIN-2 RELOCATES TO STRESS GRANULES IN
RESPONSE TO THERMAL OR OXIDATIVE STRESS. PAULA FERNANDA GOMES, DEISE
CRISTINA POLETO-SCAGLIA, MARIA LUISA PAÇÓ-LARSON
A - 16
ASSESSING THE DIFFERENTIATION OF QUAIL TRUNK NEURAL
CREST CELLS ON A 3D ENVIRONMENT.. FLAVIO AUGUSTO ROCHA BARBOSA, ANA
RAMOS HRYB, ANDRÉA GONÇALVES TRENTIN, GIORDANO WOSGRAU CALLONI
A - 17
INFLUENCE OF THE VITAMIN C AND HESPERIDIN ON THE EFFECTS
OF EXCESSIVE SUCROSE INTAKE IN RATS: A STUDY ABOUT BLOOD GLUCOSE,
MEMORY, AND DNA DAMAGE IN BLOOD AND HIPPOCAMPAL CELLS. CAMILA
MAI, PATRÍCIA MOLZ, FERNANDA FLEIG ZENKNER, DEIVIS DE CAMPOS, JOEL
HENRIQUE ELLWANGER, PAULA FENGLER, LUIZA MÜLLER, DANIEL PRÁ, SILVIA
ISABEL RECH FRANKE
A - 18
SPERM MORPHOLOGY IN MICRATHYRIA HESPERIS RIS, 1911
(ODONATA, ANISOPTERA). ANA PAULA DE ALMEIDA CAIXEIRO, LUIZ FERNANDO
GOMES, CLÁUDIA VÂNIA MIRANDA DE OLIVEIRA, JOSÉ LINO-NETO
A - 19
MORPHOLOGY OF THE PERICARDIAL NEPHROCYTES IN TERMITES
(INSECTA, ISOPTERA). ANA MARIA COSTA LEONARDO, LARA TEIXEIRA LARANJO,
VANELIZE JANEI, IVES HAIFIG
A - 20
PRESENILIN 2 REGULATES THE DEGRADATION OF RBP-JK PROTEIN
VIA P38 MITOGEN-ACTIVATED PROTEIN KINASE: DEGRADATION OF RBP-JK
INVOLVES BOTH PROTEASOME AND LYSOSOME. SU-MAN KIM, MI-YEON KIM,
EUN-JUNG ANN, JUNG-SOON MO, JI-HYE YOON, HEE-SAE PARK
A - 21
LEVELS OF ABSORPTION AND MORPHOLOGICAL ASPECTS IN FETAL
BONE OF WISTAR RATS TREATED WITH ACETATE LEAD. IURE CARVALHO DE
SOUZA, ANA PATRÍCIA SANTOS DE OLIVEIRA, RICARDO SCHER, WALDECY DE
LUCCA JUNIOR, KÁTIA MICHELLE DOS ANJOS BOMFIM, LINCOLN VÍTOR SANTOS,
VÍCTOR SANTANA SANTOS, JOSÉ ARNALDO VASCONCELOS PALMEIRA, FRANCISCO
PRADO REIS, CARLOS ALEXANDRE BORGES GARCIA, VERA LÚCIA CORRÊA FEITOSA
A - 22
LEVELS OF ABSORPTION AND MORPHOLOGICAL ASPECTS IN FETAL
SKIN OF WISTAR RATS TREATED WITH LEAD ACETATE. ANA PATRÍCIA SANTOS DE
OLIVEIRA, IURE CARVALHO DE SOUZA, RICARDO SCHER, WALDECY DE LUCCA
JUNIOR, CARLOS ALEXANDRE BORGES GARCIA, KÁTIA MICHELLE DOS ANJOS
BOMFIM, LINCOLN VÍTOR SANTOS, VÍCTOR SANTANA SANTOS, JOSÉ ARNALDO
VASCONCELOS PALMEIRA, FRANCISCO PRADO REIS, VERA LÚCIA CORRÊA FEITOSA
A - 23
MONOMERIC RECOMBINANT ARTINM ACTIVATES MAST CELLS
AND BINDS TO CALRETICULIN ON THE MAST CELL SURFACE. VALÉRIA CINTRA
BARBOSA LORENZI, MARIA CRISTINA ROQUE ANTUNES BARREIRA, MARIA CÉLILA
JAMUR, CONSTANCE OLIVER
A - 24
GANGLIOSIDE DEFICIENT MAST CELLS DO NOT EXPRESS GALECTIN1. VIVIAN MARINO MAZUCATO, ADRIANA MARIA MARIANO SILVEIRA E SOUZA,
MARCELA GIMENEZ, JOSE CESAR ROSA, LUIS LAMBERTI PINTO DA SILVA, MARIA
CELIA JAMUR, CONSTANCE OLIVER
A - 25
A NEW PHOSPHORYLATION SITE IN ALPHA-TUBULIN SUGGESTS
THAT PHOSPHORYLATION MAY BE IMPORTANT TO STABILIZE MICROTUBULES
DURING CELL DIVISION. MARIANA LEMOS DUARTE, MUNIRA MUHAMMAD ABDEL
BAQUI, HELIO MIRANDA COSTA-JUNIOR, DENISE APARECIDA BERTI, JULIO CESAR
BATISTA FERREIRA, TIAGO JOSÉ PASCHOAL SOBREIRA, MARIE-HÉLÈNE DISATNIK,
DARIA MOCHLY-ROSEN, PAULO SÉRGIO LOPES DE OLIVEIRA, DEBORAH
SCHECHTMAN
A - 26
IDENTIFICATION AND CHARACTERIZATION OF THE INTERACTION
BETWEEN THE KINASE CELL CYCLE REGULATOR KIS AND THE PROLIFERATION
MARKER CATS. ISABELLA BARBUTTI GONÇALVES, JOÃO AGOSTINHO MACHADONETO, ADRIANA S. S. DUARTE, FERNANDA SOARES NIEMANN, SARA TERESINHA
OLALLA SAAD, LETICIA FRÖHLICH ARCHANGELO
A - 27
A2BP1 IS PRESENT IN MRNP GRANULES CONTAINING THE RNA
HELICASE ME31B IN DROSOPHILA EYE DISC AND OVARIAN NURSE CELLS.
MARIANA SANTOS DE QUEIROZ, MAYARA TERRA VILLELA VIEIRA, GUSTAVO
BORGES PEREIRA, DEISE CRISTINA POLETO SCAGLIA, MARIA LUISA PAÇÓ LARSON
A - 28
GALECTIN-3 IS IMPORTANT FOR MAST CELLS MIGRATION. VANINA
DANUZA TOSO, MARIA RITA DE CÁSSIA CAMPOS, DEVANDIR ANTÔNIO DE SOUZA
JÚNIOR, MARCELO DIAS BARIFFI, MARIA CRISTINA ROQUE ANTUNES BARREIRA,
CONSTANCE OLIVER, MARIA CÉLIA JAMUR
A - 29
ANALYSIS OF INTRACELLULAR TRAFFIC MEDIATED BY RAB
PROTEINS IN HIPPOCAMPUS BEFORE PROTEIN AGGREGATION RELATED TO
NEURODEGENERATION. THAIANY QUEVEDO MELO, MERARI F. R. FERRARI
A - 30
COMBINED ACTION OF THE GROWTH HORMONE AND INSULINLIKE GROWTH FACTOR-1 ON THYMOCYTES IN VITRO. MARVIN PAULO LINS, IANA
MAYANE MENDES NICÁCIO VIANA, LARISSA FERNANDA ARAÚJO VIEIRA, SALETE
SMANIOTTO
A - 31
AEROBIC TRAINING ENHANCES THE REGENERATION PROCESS
AFTER MUSCLE ATROPHIC STIMULUS. RAQUEL SANTILONE BERTAGLIA, IVAN JOSÉ
VECHETTI-JUNIOR, PAULO HENRIQUE DO PRADO, HENRIQUE BORGATTO DE
ALMEIDA DIAS, ROBSON FRANCISCO CARVALHO, MAELI DAL PAI SILVA
A - 32
CYTOTOXICITY IN PRE-DIABETES. PATRÍCIA MOLZ, CAMILA
SCHREINER PEREIRA, MORGANA TONET MENDONÇA, THIAGO ALEY BRITES DE
FREITAS, SHARBEL WEIDNER MALUF, JORGE ANDRÉ HORTA, DANIEL PRÁ, SILVIA
ISABEL RECH FRANKE
87
A - 33
MECHANISMS INVOLVED IN THE GASTROPROTECTION INDUCED
BY EUGENIA DYSENTERICA DC (MYRTACEAE) LEAF EXTRACT IN MICE. LIGIA
CAROLINA DA SILVA PRADO, ANGÉLICA MARTINS MOREIRA MUNDIM, CAMILA
RODRIGUES FERRAZ, HUDSON ARMANDO NUNES CANABRAVA, LUIZ BORGES
BISPO-DA-SILVA
A - 34
UNDERSTANDING HEPARAN SULFATE /HEPARIN BIOSYNTHESIS.
CARINA MUCCIOLO MELO, MARIA APARECIDA PINHAL
A - 35
STUDYING
THE
INTERACTIONS
BETWEEN
LEISHMANIA
AMAZONENSIS TTAGGG REPEAT BINDING FACTOR (LATRF) AND ITS POSSIBLE
PARTNERS. JOÃO AUGUSTO RIBEIRO, DOUGLAS DIEZ GONÇALVES, ARINA MARINA
PEREZ, PAULO VINÍCIUS DA MATA MADEIRA, MARCELO SANTOS DA SILVA, MARIA
ISABEL NOGUEIRA CANO
A - 51
MORPHOLOGICAL CHARACTERIZATION OF THE EPIDERMIS OF THE
NEOTROPICAL CATFISH PIMELODELLA CF. LATERISTRIGA LICHTENSTEIN, 1823
(OSTARIOPHYSI: SILURIFORMES). KARINA MANCINI, EDUARDO MEDEIROS
DAMASCENO, LUIZ FERNANDO DUBOC, JULIANA CASTRO MONTEIRO
A - 52
EFFECTS OF YERBA MATÉ (ILEX PARAGUARIENSIS) ON ADIPOSE
TISSUE OF RATS PROGRAMMED BY EARLY WEANING. NATÁLIA DA SILVA LIMA,
ANA PAULA SANTOS DA SILVA DE OLIVEIRA, VANESSA S. TAVARES RODRIGUES,
ANDREA KAEZER, EGBERTO GASPAR DE MOURA, ELAINE DE OLIVEIRA, PATRICIA
CRISTINA LISBOA
A - 53
ENTAMOEBA HISTOLYTICA IS ABLE TO INTERNALIZE AND DEGRADE
TRYPOMASTIGOTES OF T. CRUZI G AND CL STRAINS. FLÁVIA ALVES MARTINS,
ADELE AUD RODRIGUES, MARIA APARECIDA GOMES, CLAUDIO VIEIRA DA SILVA
A - 36
IDENTIFICATION OF CANDIDATE TRANSCRIPTION FACTORS FOR
THE REGULATION OF RAT VENTRAL PROSTATE GLAND RESPONSE TO ANDROGEN
DEPRIVATION AND HIGH DOSE 17BETA-ESTRADIOL ADMINISTRATION. RAFAELA
DA ROSA RIBEIRO, RAMON OLIVEIRA VIDAL, HERNADES F. CARVALHO
A - 54
AGE EFFECTS ON CHROMATIN SUPRA-ORGANIZATION OF
CORTICAL NEURONS FROM MICE. HENRIQUE FERREIRA RODRIGUES, TAFAREL
ANDRADE DE SOUZA, FLAVIA GERELLI GHIRALDINI, MARCELO EMILIO BELETTI,
MARIA LUIZA SILVEIRA MELLO, ALBERTO DA SILVA MORAES
A - 37
AEROBIC TRAINING HAS ANTI ATROPHY BENEFICIAL AND CARDIAC
REMODELING EFFECTS IN RATS WITH HEART FAILURE. WARLEN PEREIRA
PIEDADE, RODRIGO WAGNER ALVES DE SOUZA, LUANA CAMPOS SOARES, DIJON
HENRIQUE SALOMÉ CAMPOS, PAULA AIELLO TOMÉ DE SOUZA, ANTONIO CARLOS
CICOGNA, MAELI DAL-PAI-SILVA
A - 55
EXPRESSION AND FUNCTION OF PSG, STARD7 AND KLF6 GENES IN
HUMAN TROPHOBLAST CELLS. PANZETTA-DUTARI GM, RACCA AC., CAMOLOTTO
S., RIDANO ME., FLORES-MARTIN J., RENA V., GENTI-RAIMONDI S
A - 38
AMPHOTERICIN B INDUCES APOPTOSIS ON A CELL LINE OF
HEPATIC STELLATE CELLS. CAROLINA URIBE CRUZ, FERNANDA OLIVEIRA DOS
SANTOS, NELSON ALEXANDDRE KRETZMANN, THEMIS REVERBEL DA SILVEIRA,
URSULA MATTE
A - 39
EFFECT
OF
POSACONAZOLE
ON
THREE-DIMENSIONAL
CARDIOMYOCYTES CULTURE DURING TRYPANOSOMA CRUZI INFECTION WITH
EMPHASIS IN EXTRACELLULAR MATRIX PROTEINS AND GAP JUNCTIONS. LÍNDICE
MITIE NISIMURA, PATRÍCIA MELLO FERRÃO, LAURA LACERDA COELHO, LUCIANA
RIBEIRO GARZONI
A - 40
LUEHEA INFUSION OINTMENT IMPROVES WOUNDED EPIDERMAL
TISSUE HEALING IN WISTAR RATS. PAULO CÉSAR FERREIRA DOS SANTOS, TATIANA
MORDENTE CLEMENTE, FABRÍCIO CASTRO MACHADO, FERNANDA MIYAGAKI
SHOYAMA, CLAUDIO VIEIRA DA SILVA
A - 41
LIVER HISTOLOGY OF THE THREE TELEOST SPECIES CAPTURED IN
THE ITAPECERICA RIVER, DIVINÓPOLIS, MG, BRAZIL. REGIANNE FERREIRA SILVA,
CAMILA FERREIRA SALES, MARILIA GABRIELA C AMARAL, HEDER J. RIBEIRO, ROSY I.
MACIEL AZAMBUJA RIBEIRO, FABRICIO FLÁVIO THEOPHILO DOMINGOS, RALPH
GRUPPI THOMÉ, HÉLIO BATISTA DOS SANTOS
A - 42
MASTER SWITCH REGULATORY GENES INVOLVED WITH PROSTATE
GLAND REMODELING AFTER CASTRATION. UMAR NISHAN, DANILO MARCHETE
DAMAS DE SOUZA, GUILHERME OLIVEIRA BARBOSA, HERNANDES F. CARVALHO
A - 43
PLANTS EXTRACTS AND HUMAN PLATELETS MODULATE MAST
CELLS POPULATION IN SKIN WOUND HEALING. LUCIANA XAVIER PEREIRA, RAÍSSA
DE OLIVEIRA AQUINO SCHÜFFNER, PATRÍCIA PEREIRA SILVA, HÉLIO BATISTA
SANTOS, RALPH GRUPPI THOMÉ, HÉLIO CHIARINI GARCIA, ROSSANA CORREA
NETTO DE MELO, ROSY IARA MACIEL DE AZAMBUJA RIBEIRO, GLEYDES GAMBOGI
PARREIRA
A - 44
TOPICAL ANTIMICROBIAL ACTIVITY OF OLEIC AND LINOLEIC ACIDS
IN WOUNDS. MAYSA BRAGA BARROS SILVA, GILSON MASAHIRO MURATA, RUI
CURI, ANDREA MARIA SPESSOTO, ELAINE HATANAKA
A - 45
FEZ1 PROTEIN-PROTEIN INTERACTION NETWORK GIVING CLUES
TO CELLULAR PROCESSES: THE AUTOPHAGY MACHINERY IN NEUROGENESIS AND
LEUKEMIA. ARIANE DA SILVA FURLAN, MARCOS RODRIGO ALBORGHETTI, DEIVID
LUCAS DOS SANTOSMIGUELETI, JÚLIO CÉSAR SILVA, IRIS CONCEPCION LINARES DE
TORRIANI, HOZANA ANDRADE CASTILLO, JOSE XAVIER NETO, JORG KOBARG
A - 46
2D-DIGE ANALYSES IN PROTEIN EXPRESSION IN HUMAN
UMBILICAL VEIN ENDOTHELIAL CELLS: THE EFFECT OF HYPOXIA IN VITRO AND IN
UTERO. ANDRÉS CANIUGUIR, BERNARDO KRAUSE, ERNESTO MUÑOZ, PAOLA
CASANELLO
A - 47
STREPTOMYCIN EFFECTS IN STRETCH-ACTIVATED CHANNEL
PROTEIN TRPC1 LEVELS AND MYONECROSIS OF MDX MICE. CINTIA YURI
MATSUMURA, ANA PAULA TIEMI TANIGUTI, LETÍCIA MONTANHOLI APOLINÁRIO,
HUMBERTO SANTO NETO, MARIA JULIA MARQUES
A - 48
MIDGUT OF THE DIPLOPOD UROSTREPTUS ATROBRUNNEUS:
STRUCTURE, FUNCTION AND REDEFINITION OF HEPATIC CELLS. CRISTINA
MOREIRA DE SOUSA, ALDINEI GONÇALVES JUNIOR, CARMEM SILVIA FONTANETTI,
MONIKA IAMONTE
A - 49
DIFFERENTIAL EFFECTS OF CHEMOATTRACTANTS ON MAST CELL
RECRUITMENT. MARIA RITA DE CÁSSIA CAMPOS, CONSTANCE OLIVER, MARIA
CELIA JAMUR
A - 50
RESERVE AND URATE STORAGE IN THE FAT BODY CELLS DURING
SOLDIER DIFFERENTIATION IN THE TERMITE HETEROTERMES TENUIS (ISOPTERA,
RHINOTERMITIDAE). LARA TEIXEIRA LARANJO, ANA MARIA COSTA LEONARDO
A - 56
CYTOCHEMISTRY OF CLUB CELLS IN THE EPIDERMIS OF THE
CATFISH PIMELODELLA CF. LATERISTRIGA LICHTENSTEIN, 1823 (OSTARIOPHYSI:
SILURIFORMES). LUIZ FERNANDO DUBOC, JULIANA CASTRO MONTEIRO, KARINA
CARVALHO MANCINI, EDUARDO MEDEIROS DAMASCENO
A - 57
ULTRASTRUCTURE OF CLUB CELLS IN THE EPIDERMIS OF THE
NEOTROPICAL CATFISH PIMELODELLA CF. LATERISTRIGA LICHTENSTEIN, 1823
(OSTARIOPHYSI: SILURIFORMES. EDUARDO MEDEIROS DAMASCENO, LUIZ
FERNANDO DUBOC, JULIANA CASTRO MONTEIRO, KARINA CARVALHO MANCINI
A - 58
TREATMENT WITH VOCHYSIA SP (VOCHYSIACEAE) EXTRACT IN
STREPTOZOTOCIN-INDUCED DIABETIC RATS ATTENUATED GLYCEMIA WITHOUT
ALTERING MORPHOLOGY OF HEPATIC TISSUE. IZABELA BARBOSA MORAES,
CAMILLA MANZAN MARTINS, NEIRE MOURA DE GOUVEIA, LUCIANA KAREN
CALÁBRIA, KAREN RENATA NAKAMURA HIRAKI, ALBERTO DA SILVA MORAES,
FOUED SALMEN ESPINDOLA
A - 59
STRATEGIES FOR IMMOBILIZATION OF MESENCHYMAL STEM
CELLS USING SUPER-HYDROPHILIC VERTICALLY ALIGNED CARBON NANOTUBES
AND DISPERSED MAGNETICALLY ORIENTED CARBON NANOTUBES. ALESSANDRO
EUSTAQUIO CAMPOS GRANATO, LAYLA TESTA GALINDO, TAÍS ADELITA BARROS,
MARCELLA BRAGA DA COSTA REIS, PIERO BAGNARESI, LILIAN SIQUEIRA,
ANDERSON DE OLIVEIRA LOBO, MARIMÉLIA PORCIONATTO
A - 60
MEDIUM-TERM TREATMENT WITH CYCLOSPORIN A AND
HETEROPTERYS TOMENTOSA, INVESTIGATED IN HEPATIC TISSUE OF WISTAR
RATS. KARINE DE MOURA FREITAS, MARIA APARECIDA DA SILVA DIAMANTE,
JACQUELINE MERIELLEN DE ALMEIDA, NAYARA RUDECK COCK, MARÇAL
HENRIQUE AMICI JORGE, MARY ANNE HEIDI DOLDER
A - 61
CLONING, EXPRESSION AND BIOLOGICAL CHARACTERIZATION OF
A NOVEL PHOSPHOLIPASE-D FROM BROWN SPIDER (LOXOSCELES INTERMEDIA)
VENOM. GABRIEL OTTO MEISSNER, LARISSA VUITIKA, DILZA TREVIZAN SILVA,
LUIZA HELENA GRESMKI, OLGA MEIRI CHAIM, MATHEUS REGIS BELISÁRIO,
ADRIANO MARCELO MORGON, SILVIO SANCHES VEIGA
A - 62
EFFECT OF ACARBOSE AND PHASEOLAMINE TREATMENTS ABOUT
LIVER MORPHOLOGY IN STREPTOZOTOCIN-INDUCED DIABETIC RATS. CAMILLA
MANZAN MARTINS, IZABELA BARBOSA MORAES, KAREN RENATA NAKAMURA
HIRAKI, NEIRE MOURA GOUVEIA, LUCIANA KAREN CALÁBRIA, FOUED SALMEN
ESPINDOLA
A - 63
MELATONIN EFFECTS IN PROSTATE HISTOPHYSIOLOGY OF
PREPUBERTAL RATS SUBJECTED TO SHORT TERM DIABETES. MARINA
GUIMARÃES GOBBO, GUILHERME HENRIQUE TAMARINDO, VIVIANE SANCHES
MASITÉLI, CAROLINA FRANDSEN PEREIRA COSTA, SEBASTIÃO ROBERTO TABOGA,
REJANE MAIRA GÓES
A - 64
TOXICITY IN LIVER OF FISH SPECIES OREOCHROMIS NILOTICUS
(CICHLIDAE) EXPOSED TO NICL2. AMANDA ALFONSO BATISTA, CINTYA A
CHRISTOFOLETTI, CARMEM S. FONTANETTI
A - 65
EFFECT OF VOCHYSIA SP. EXTRACT ON THE MORPHOMETRY OF
THE PAROTID GLAND IN STREPTOZOTOCIN-INDUCED DIABETIC RATS. DOUGLAS
CARVALHO CAIXETA, FRANCYELLE BORGES ROSA DE MOURA, ALICE VIEIRA DA
COSTA, LUCIANA KAREN CALÁBRIA, MARCELO EMÍLIO BELETTI, FOUED SALMEN
ESPINDOLA
A - 66
IN SILICO ANALYSIS OF BINDING PEPTIDES TO CELL SURFACE FROM
STAPHYLOCOCCUS AUREUS. FERNANDO VIEIRA RODRIGUES, EMÍLIA REZENDE
VAZ, CAROLINE FERNANDES REIS, LÉA DUARTE DA SILVA MORAES, YARA CRISTINA
DE PAIVA MAIA, CARLOS UEIRA VIEIRA, LUIZ RICARDO GOULART, TATIANA
AMABILE DE CAMPOS
A - 67
HISTOLOGY AND HISTOCHEMICAL CHARACTERIZATION OF THE
STOMACH STRUCTURE OF ANTARCTIC FISH NOTOTHENIA ROSSII (RICHARDSON,
1844) UNDER CONDITIONS OF THERMAL STRESS. PRISCILA KREBSBACH, AXEL H.
R. COFRÉ, CINTIA MACHADO, MARIA ROSA D. PEDREIRO, FLÁVIA B. V. SILVA,
88
TÂNIA ZALESKI, LUCIANA B. CETTINA, MARIANA FORGATI, CLÁUDIO A. PIECHNIK,
LUCÉLIA DONATTI
A - 68
ASSESSMENT OF SUBCHRONIC ORAL TOXICITY OF ETHANOLIC
EXTRACT OF MAYTENUS ILICIFOLIA MART. EX REISSEK. IN MALE AND FEMALE
WISTAR RATS. SILVANE SOUZA ROMAN, CARLA GIANE LOSS, TAÍS REGINA
FIORENTIN, FABIOLA REGINA BREDA, GABRIELA GUBERT, MORGANA PISTORE,
JANAINA VIEIRA BELUSSO, MICHELA BIANCHI DE MELLO, ARNO ERNESTO
HOFMANN JUNIOR
A - 69
INVESTIGATION OF NTPDASE-2 ROLE IN CELL ADHESION,
PROLIFERATION AND MIGRATION. FRANCIELE CRISTINA KIPPER, DARLAN
CONTERNO MINUSSI, GUIDO LENZ, MÁRCIA ROSÂNGELA WINK
A - 70
THE CHARACTER PROTEIN OF PROSTATE GERBIL: MALE INTACT
AND FEMALE RECEIVED SUPPLEMENTATION OF TESTOSTERONE. PEDRO
HENRIQUE GARCIA SOBRINHO, ANA PAULA DA SILVA PEREZ, FÁTIMA PEREIRA DE
SOUZA, SEBASTIÃO ROBERTO TABOGA
A - 71
ENDOPLASMIC RETICULUM STRESS IS AN EVOLVING FEATURE OF
AORTIC DISEASE IN HETEROZYGOUS MARFAN SYNDROME MICE, WHILE NOT
ACCOUNTED FOR BY FIBRILLIN-1 MUTATION ITSELF. THAYNA MEIRELLES SANTOS,
MARIA CAROLINA GUIDO, VICTOR DEBBAS, LYGIA DA VEIGA PEREIRA, FRANCISCO
RAFAEL MARTINS LAURINDO
A - 72
BIOCOMPATIBILITY EVALUATION OF SOLID LIPID NANOPARTICLES
TOWARD MOUSE EMBRYO FIBROBLASTS AND ERITHROCYTES. ADNY HENRIQUE
SILVA, CARINE DAL PIZZOL, FABÍOLA B. FILIPPIN-MONTEIRO, ÂNGELA M. DE
CAMPOS, TÂNIA B.CRECZYNSKI-PASA
A - 73
ARREST OF CYTOPLASMIC STREAMING INDUCES ALGAL
PROLIFERATION IN GREEN PARAMECIA. HIROSHI HOSOYA, EIJI HIRAKI, KOYO
TETSUKAWA, YOSHIHIKO YAMASHIN, TOSHIYUKI TAKAHASHI, KOZUE HAMAO
A - 74
NITRIC OXIDE PRODUCTION BY HEMOCYTES OF THE ASCIDIAN
PHALLUSIA NIGRA. LAURA CARRIELLO EMRICH, DANIELLY DA FONTE CARVALHO
MARTINS, RODRIGO NUNES DA FONSECA, SILVANA ALLODI, CINTIA MONTEIRO DE
BARROS
A - 75
DIPHOSPHORYLATED MYOSIN II REGULATORY LIGHT CHAIN
LOCALIZES TO THE MIDZONE WITHOUT ITS HEAVY CHAIN DURING CYTOKINESIS.
TOMO KONDO, KEIJU KAMIJO, KOZUE HAMAO, HIROSHI HOSOYA
A - 85
MAINTENANCE OF BIOCHEMICAL PROPERTIES OF CHONDROCYTES
IN VITRO UNDERGOING CHONDROGENIC MEDIUM RICH IN FACTOR. RICARDO
SCHMID BOMFIM, CAMILA BASILE CARBALLO
A - 86
RECOMBINANT PHOSPHOLIPASE-D FROM BROWN SPIDER VENOM
(LOXOSCELES GENUS) INDUCES CYTOSOLIC CALCIUM INFLUX AND DEGRADATION
OF PLASMA MEMBRANE PHOSPHOLIPIDS OF B16-F10 CELLS. ANA CAROLINA
MARTINS WILLE, DANIELLE CHAVES MOREIRA, MARIANA G. MAGNONI, THIAGO
LOPES DE MARI, LUIZA HELENA GREMSKI, OLGA MEIRI CHAIM, ANDREA SENFF
RIBEIRO, SILVIO SANCHES VEIGA
A - 87
DOUBLE STRAND BREAK REPAIR PROTEINS IDENTIFICATION IN
MAMMALIAN MITOCHONDRIA. VALQUIRIA TIAGO DOS SANTOS, NADJA
CRISTHINA DE SOUZA PINTO
A - 88
THE PRESENCE OF THE SYMBIOTIC BACTERIUM INFLUENCES THE
O2 CONSUMPTION IN ITS HOST CELL, ANGOMONAS DEANEI. ALLAN CÉZAR DE
AZEVEDO MARTINS, ANA CAROLINA LOYOLA MACHADO, ANTÔNIO GALINA,
LUCIANE CIAPINA, LUIZ GONZAGA, ANA TEREZA RIBEIRO VASCONCELOS,
WANDERLEY DE SOUZA, MARCELO EINICKER LAMAS, MARIA CRISTINA MACHADO
MOTTA
A - 89
THE TETRASPANIN CD63 IS HIGHLY EXPRESSED BY SECRETORY
GRANULES IN HUMAN BLOOD EOSINOPHILS. LÍVIA ANDRESSA SILVA DO CARMO,
KÁTIA BATISTA DO AMARAL, ANN M. DVORAK, PETER F. WELLER, ROSSANA
CORREA NETTO DE MELO
A - 90
THE INFLUENCE OF THE SYMBIOTIC BACTERIUM ON RESPIRATION
OF HOST TRYPANOSOMATIDS STRIGOMONAS CULICIS. ANA CAROLINA LOYOLA
MACHADO, DALLAN CÉZAR DE AZEVEDO MARTINS, ANTÔNIO GALINA FILHO,
WANDERLEY DE SOUZA, MARIA CRISTINA MACHADO MOTTA
A - 91
AGE–RELATED CHANGES IN LIVER MORPHOLOGY: COULD
HETEROPTERYS TOMENTOSA ALLEVIATE THESE CHANGES? MARIA APARECIDA DA
SILVA DIAMANTE, FABRICIA DE SOUZA PREDES, ANA MILENA HERRERA, JULIANA
DE CASTRO MONTEIRO, MARY ANNE HEIDI DOLDER
A - 92
HISTOPATHOLOGICAL CHANGES IN THE ANTARCTIC FISH
NOTOTHENIA CORIICEPS AND NOTOTHENIA ROSSII COLLECTED IN KING GEORGE
ISLAND, ANTARCTIC PENINSULA. MARIA ROSA DMENGEON PEDREIRO, FLÁVIA
SANT`ANNA RIOS, CINTIA MACHADO, PRISCILA KREBSBACH, CLÁUDIO ADRIANO
PIECHNIK, TANIA ZALESKI, MARIANA FORGATI, LUCIANA BADELUK CETTINA,
EDSON RODRIGUES, LUCÉLIA DONATTI
A - 76
COMPARATIVE HISTOLOGY OF THE SPLEEN OF THREE TELEOST
SPECIES CAPTURED IN THE ITAPECERICA RIVER, DIVINÓPOLIS, MG, BRAZIL.
MARILIA GABRIELA C AMARAL, REGIANNE FERREIRA SILVA, CAMILA FERREIRA
SALES, HEDER J. RIBEIRO, ROSY I. MACIEL AZAMBUJA RIBEIRO, FABRICIO FLÁVIO
THEOPHILO DOMINGOS, RALPH GRUPPI THOMÉ, HÉLIO BATISTA DOS SANTOS
A - 93
TC95 A HYBRID MOLECULE ON LEISHMANIA AMAZONENSIS: NEW
CELLULAR TARGETS. JOSEANE LIMA PRADO GODINHO, K. GEORGIKOPOULOU, T.
CALOGEROPOULOU, WANDERLEY DE SOUZA, JULIANY COLA FERNANDES
RODRIGUES
A - 77
USING A CACO-2 CELL CULTURE MODEL FOR DRUG PERMEATION.
JULIANNA HENRIQUES DA SILVA, VIVIANE LIONE, RITA DE CASSIA ASCENÇÃO
BARROS, CARLOS RANGEL RODRIGUES, HELENA CARLA CASTRO, VALERIA P.
SOUSA, LUCIO MENDES CABRAL, LUIZ EURICO NASCIUTTI
A - 94
BIOLOGY OF CIRCULATING ENDOTHELIAL PROGENITOR CELLS IN
THE CONTEXT OF OBESITY IN ADOLESCENTS. BRUNO DIAZ PAREDES, ELIETE
BOUSKELA, LUIZ GUILHERME KRAEMER DE AGUIAR, VERÔNICA MORANDI,
MARCELA FERREIRA MARQUES
A - 78
NOREPINEPHRINE DEPRESSES THE NITRIC OXIDE PRODUCTION IN
THE ASCIDIAN PHALLUSIA NIGRA HEMOCYTES. ANDRESSA DE ABREU MELLO,
SILVANA ALLODI, CINTIA MONTEIRO DE BARROS
A - 95
ULTRASTRUCTURAL AND CYTOGENETIC CHARACTERIZATION OF
SOME ASPECTS OF SPERMATOGENESIS OF ZAPRIONUS INDIANUS AND
ZAPRIONUS SEPSOIDES. LETÍCIA DO NASCIMENTO ANDRADE DE ALMEIDA REGO,
ROSANA SILISTINO DE SOUZA, MARIA TERCÍLIA VILELA DE AZEREDO OLIVEIRA,
LILIAN MADI-RAVAZZI
A - 79
PURINERGIC RECEPTORS ARE INVOLVED IN THE ACTIVATION OF
MACROPHAGES BY URIC ACID CRYSTALS THROUGH THE NLRP3-INFLAMMASOME
PATHWAY. THOMAS GICQUEL, TATIANA VICTONI, ALAIN FAUTREL, FLORENCE
GLEONNEC, CARINE LAMBERT, CARINE LAMBERT, ISABELLE COUILLIN, ELISABETH
BOICHOT, VINCENT LAGENTE
A - 80
ADDITIVE EFFECT OF CIGARETTE SMOKE EXTRACT (CSE) AND
LIPOLYSACCHARIDE (LPS) ON PROINFLAMMATORY CYTOKINE RELEASE
THROUGH ACTIVATION OF JAK/STAT PATHWAYS IN HUMAN AIRWAY EPITHELIAL
CELLS. TATIANA VICTONI, MANUELLA LANZETTI, FLORENCE GLEONNEC, LUCIE
BEAUTRAIS, SAMUEL S. VALENÇA, LUIS CRISTOVÃO PORTO, ELISABETH BOICHOT,
VINCENT LAGENTE
A - 81
EFFECTS OF TREATMENTS WITH DIFFERENT ULTRASOUND FIELDS
IN SKELETAL MUSCLE CELL CULTURES. VIVIANE M. ABRUNHOSA, CAROLINA
PONTES SOARES, RODRIGO COSTA-FELIX, MANOEL COSTA, CLAUDIA
MERMELSTEIN
A - 82
EFFECTS OF ANTIFUNGAL ON SPOROTHRIX SCHENCKII. LUANA
PEREIRA BORBA DOS SANTOS, KELLY ISHIDA, LEILA MARIA LOPES BEZERRA, SONIA
ROZENTAL
A - 83
LIPID DROPLETS INDUCTION IN MURINE MACROPHAGES WITH
MICE SERUM: POSSIBLE PROTEINACEOUS NATURE OF THE INDUCTION FACTOR.
THIAGO TORRES DE AGUIAR, LAURA AZEREDO MIRANDA MOTA, SÉRGIO
HENRIQUE SEABRA, PATRÍCIA TORRES BOZZA, GEÓRGIA CORREA ATELLA, RENATO
AUGUSTO DAMATTA
A - 84
HIGH-FAT DIET ENRICHED WITH FISH OIL DECREASES LYMPHOCYTE
ACTIVATION IN MICE. HELOÍSA HELENA DE OLIVEIRA ALVES, CESAR MIGUEL
MOMESSO, JARLEI FIAMONCINI, KIM GUIMARÃES CAÇULA, MARIA FERNANDA
CURY-BOAVENTURA, SANDRO MASSAO HIRABARA, RUI CURI, RENATA GORJÃO
A - 96
EVIDENCES OF DEGRANULATION IN HOLOTHURIA
SPHERULOCYTES. PATRICIA LACOUTH, MÁRCIO REIS CUSTÓDIO
GRISEA
A - 97
CELLULAR RESPONSE OF SKIN FIBROBLAST TO LEISHMANIA
(LEISHMANIA) AMAZONENSIS INFECTION. CAMILA GUERRA SILVA, ROGER
MAGNO MACEDO SILVA, CARINA DE LIMA PEREIRA DOS SANTOS, VANESSA
ALVARO DINIZ, SUZANA CÔRTE-REAL
A - 98
ADENOHYPOPHYSEAL CELLS IN ADULTS OF SALMINUS
BRASILIENSIS (TELESOSTEI, CHARACIFORMES): A HISTOCHEMYCAL AND
IMUNOHISTOCHEMYCAL STUDY. LÁZARO WENDER OLIVEIRA DE JESUS, CHAYRRA
CHERRADE GOMES, GISELE CRISTIANE DE MELO DIAS, SARA ZAGO GOMES, CRUZ
ALBERTO MENDOZA RIGONATI, MARIA INÊS BORELLA
A - 99
EVALUATION OF BME26 CELLS RESISTANCE TO HYDROGEN
PEROXIDE INDUCED STRESS. BÁRBARA PITTA DELLA NOCE, JORGE LUIS RIBEIRO,
RENATO AUGUSTO DAMATTA, CARLOS LOGULLO
A - 100
INSIGHTS ABOUT FIBROCYTES PARTICIPATION IN THE IMMUNE
RESPONSE OF LEISHMANIASIS. CARINA DE LIMA PEREIRA DOS SANTOS, THAISA
VIEIRA, VANESSA ALVARO DINIZ, CAMILA GUERRA SILVA, ROGER MAGNO
MACEDO SILVA, JORGE JOSÉ DE CARVALHO, SUZANA CÔRTE-REAL
A - 101
THE ROLE OF HISTONE H4 IN THE TRYPANOSOMA CRUZI
CHROMATIN. THIAGO CESAR PRATA RAMOS, BRUNO DOS SANTOS PASCOALINO,
SHEILA CRISTINA NARDELLI, SERGIO SCHENKMAN
A - 102
CELLULAR REDISTRIBUTION OF A PROTEIN KINASE INVOLVED IN
TRANSLATION CONTROL DURING DIFFERENTIATION OF TRYPANOSOMA CRUZI.
LEONARDO DA SILVA AUGUSTO, NILMAR SILVIO MORETTI, SERGIO SCHENKMAN
A - 103
ICK PEPTIDE FROM LOXOSCELES INTERMEDIA VENOMOUS GLAND:
CLONING, EXPRESSION AND PRODUCTION OF POLYCLONAL ANTIBODIES.
89
FERNANDO HITOMI MATSUBARA, EDUARDO SOARES CONSTANTINO LOPES,
GABRIEL OTTO MEISSNER, VALÉRIA PEREIRA FERRER, LUIZA HELENA GREMSKI,
ANDREA SENFF RIBEIRO, OLGA MEIRI CHAIM, SILVIO SANCHES VEIGA
A - 104
STUDY OF THE VENTRAL PROSTATE EMBRYOGENESIS IN
MONGOLIAN GERBIL. BRUNO DOMINGOS AZEVEDO SANCHES, MANOEL
FRANCISCO BIANCARDI, LUIZ ROBERTO FALLEIROS-JR, FERNANDA CRISTINA
ALCANTARA DOS SANTOS, SEBASTIÃO ROBERTO TABOGA
A - 105
TGFB EFFECT IN NUCLEAR TRANSLOCATION OF CLUSTERIN IN
RWPE-1 TRANSFECTED WITH A CLU-GFP CLONE AND ITS IMMUNOLOCALIZATION
IN DU145 AND PC3 CELLS. FABIANA KUHNE, GUSTAVO DE MAGALHÃES ALMEIDA,
HERNANDES F CARVALHO
A - 106
THYROID HORMONE (T3) MODULATES THE ENTERIC GLIA. ANA
CARINA BON FRAUCHES OLIVEIRA, SUZANA ASSAD KAHN, ANA LÚCIA TAVARES
GOMES, PATRÍCIA CASTELUCCI, VIVALDO MOURA NETO
A - 107
RODLET CELLS IN GILL EPITHELIUM OF CURIMBA (PROCHILODUS
ARGENTEUS): ULTRASTRUCTURE AND S100 IMMUNOREACTIVITY. MARCELA
SANTOS PROCÓPIO, HEDER JOSÉ RIBEIRO, SAMYRA MARIA DOS SANTOS NASSIF
LACERDA, PATRÍCIA MASSARA MARTINELLI, JOSÉ DIAS CORRÊA JUNIOR
A - 108
HISTOCHEMICAL AND BIOCHEMICAL IDENTIFICATION OF THE
GLYCOCONJUGATE TYPE IN SECRETION OF THE PAROTOID GLAND OF A
BRAZILIAN TOAD (RHINELLA ICTERICA). JULIANE SIQUEIRA FRANCISCO, ELIENE
OLIVEIRA KOZLOWSKI DE FARIAS, MAURO SÉRGIO GOLÇALVES PAVÃO, LYCIA DE
BRITO GITIRANA
A - 109
5-HYDROXY-2-HYDROXYMETHYL-PYRONE
(HMP)
AS
MACROPHAGE ACTIVATOR. ANA PAULA DRUMMOND RODRIGUES, LUIS
HENRIQUE SEABRA DE FARIAS, ALBERDAN SILVA SANTOS, JOSÉ LUIZ MARTINS DO
NASCIMENTO, EDILENE OLIVEIRA DA SILVA
A - 110
EVALUATION OF LEISHMANICIDAL ACTIVITY OF RHIZOPHORA
MANGLE ON LEISHMANIA MAJOR. KRISIA EMANUELLE FERREIRA DA SILVA,
ERWELLY BARROS DE OLIVEIRA, MARLLON ALEX NASCIMENTO SANTANA, PAULO
HENRIQUE CAVALCANTI DE ARAÚJO, ANTÔNIO FERNANDO MORAIS DE OLIVEIRA,
PALOMA LYS DE MEDEIROS, ELIETE CAVALCANTI DA SILVA, JEYMESSON RAPHAEL
CARDOSO VIEIRA
A - 111
EFFECTS OF 5-HYDROXY-2-HYDROXYMETHYL-GAMMA-PYRONE
(HMP), A SECONDARY METABOLITE OBTAINED FROM ASPERGILLUS FUNGI, ON
HUMAN NEUTROPHILS. PAULA CRISTINA RODRIGUES FRADE, JOSINEIDE PANTOJA
DA COSTA, ANA PAULA DRUMMOND RODRIGUES, LUIS HENRIQUE SEABRA
FARIAS, BRUNO JOSÉ MARTINS DA SILVA, RAQUEL RAICK PEREIRA DA SILVA,
AMANDA ANASTÁCIA PINTO HAGE, CAROLINE MARTINS ALMEIDA, ALBERDAN
SILVA SANTOS, EDILENE OLIVEIRA DA SILVA
A - 112
RST-NEPH PROTEIN FAMILY IN CHICK EMBRYOS. MARA SILVIA
ALEXANDRE COSTA, FELIPE MONTELEONE VIECELI, LUANA CRISTINA AMISTA, JOSÉ
EDUARDO BARONEZA, MAIARO CABRAL ROSA MACHADO, IRENE YAN, RICARDO
GUELERMAN PINHEIRO RAMOS
A - 113
EFFECTS OF 5-HYDROXY-2-HYDROXYMETHYL--PYRONE (HMP) IN
FILAMENTOUS FUNGAL CURVULARIA PALLESCENS. JORGE AUGUSTO LEÃO
PEREIRA, ANA PAULA DRUMMOND RODRIGUES, DAVI MARCOS DE SOUZA
OLIVEIRA, ALBERDAN SILVA SANTOS, EDILENE OLIVEIRA DA SILVA
A - 114
DIFFERENTIATION OF HUMAN MONOCYTES IN VITRO BY 5HYDROXY-2-HYDROXYMETHYL-GAMMA-PYRONE (HMP), A BIOPRODUCT
OBTAINED FROM ASPERGILLUS FUNGI. JOSINEIDE PANTOJA DA COSTA, PAULA
CRISTINA RODRIGUES FRADE, ANA PAULA DRUMMOND RODRIGUES, BRUNO JOSÉ
MARTINS DA SILVA, ALBERDAN SILVA SANTOS, EDILENE OLIVEIRA DA SILVA
A - 115
DELETERIOUS EFFECTS OF WATER-SOLUBLE FRACTION (WSF) OF
PETROLEUM ON BEIJUPIRÁ (RACHYCENTRON CANADUM): HISTOLOGICAL
EVALUATION. KARINA FERNANDES REZENDE, LÍGIA MARIA SALVO, JULIANA
CRISTINA TEIXEIRA DE MORAES, DIVINOMAR SEVERINO, JOSÉ ROBERTO
MACHADO CUNHA DA SILVA
A - 116
ANALYSIS OF LIPID DROPLETS IN LEISHMANIA (VIANNIA)
BRAZILIENSIS PROMASTIGOTES IN THE EARLY STATIONARY PHASE OF THE
GROWTH. AMANDA ANASTÁCIA PINTO HAGE, NUCCIA N. T. DE CICCO, GEORGIA C.
ATELLA, RAQUEL RAICK PEREIRA DA SILVA, BRUNO JOSÉ MARTINS SILVA, PAULA
CRISTINA R. FRADE, ANA PAULA DRUMMOND RODRIGUES, EDILENE OLIVEIRA DA
SILVA
A - 117
Α6Β1 INTEGRIN IS RELEVANT IN THE FORMATION AND SURVIVAL
OF DIFFERENTIATED 3D ACINI OF SALIVARY GLANDS CELLS: IMPLICATIONS IN
SJÖGREN’S SYNDROME. HERY ANDRÉS URRA ZÚÑIGA, DENISSE SEPULVEDA, JUAN
CORTES, VERONICA BAHAMONDES, ISABEL CASTRO, MARIA JOSE BARRERA,
SERGIO AGUILERA, CLAUDIO MOLINA, CECILIA LEYTON, CECILIA ALLENDE, SERGIO
GONZALEZ, MARÍA JULIETA GONZÁLEZ
A - 118
FURTHER STUDIES OF THE IN SITU CELL STRUCTURE OF CELLS AND
TISSUES WITH THE ATOMIC FORCE MICROSCOPE. MARÍA DE LOURDES SEGURAVALDEZ, GEORGINA ALVAREZ-FERNÁNDEZ, ALMA ZAMORA-CURA, ASIER GARCÍA
SENOSIAIN, LOURDES TERESA AGREDANO-MORENO, LUIS FELIPE JIMÉNEZ-GARCÍA
A - 119
DISTRIBUTION OF AMINOPEPTIDASES IN SUBCELLULAR
FRACTIONS OF ADIPOCYTES FROM ABDOMINAL FAT IN MONOSODIUM
GLUTAMATE OBESITY. RAFAELA FADONI ALPONTI, PAULO FLAVIO SILVEIRA
A - 120
MELANOPSIN ACTIVATES CLOCK GENES IN ZEBRAFISH CELLS.
BRUNO CESAR RIBEIRO RAMOS, MARIA NATHÁLIA DE CARVALHO MAGALHÃES
MORAES, LEONARDO HENRIQUE RIBEIRO GRACIANI DE LIMA, ANA MARIA DE
LAURO CASTRUCCI
A - 121
HISTOPATHOLOGICAL CHANGES IN THE GILLS OF ARAPAIMA
GIGAS AFTER BATHS IN FORMALDEHYDE SOLUTION. JOSÉ CARLOS NUNES
RAULINO, SANNY MARIA DE ANDRADE-PORTO, LUCIANA ARRUDA DINÓLA DE
OLIVEIRA, JOSE CELSO DE OLIVEIRA MALTA
A - 122
MUCOUS CELLS IN GILLS OF ARAPAIMA GIGAS EXPOSED TO WHITE
AND BLACK WATERS AND ITS INFLUENCE ON FISH HOMEOSTASIS. JOSÉ CARLOS
NUNES RAULINO, JANILSON MORAES SERUDO, ELIZABETH GUSMÃO AFFONSO,
OSCAR TADEU FERREIRA DA COSTA, WALLICE LUIZ PAXIÚBA DUNCAN, MARISA
NARCISO FERNANDES, CLEVERSON AGNER RAMOS
B – Cell Biology and
Cancer
B1-B252
B-1
NUCLEAR CALCIUM BUFFERING SENSITIZES HUMAN SQUAMOUS
CELL CARCINOMA TO X-RAYS USING HEAD AND NECK RADIOTHERAPY
PROTOCOL. LÍDIA MARIA DE ANDRADE, JONY MARQUES GERALDO, OSVALDO
XAVIER GONÇALVES, MIGUEL TORRES TEIXEIRA LEITE, ANDERSON MIRANDA
CATARINA, ADRIANA FRANCO PAES LEME, SAMI YOOKO, CARLOS RENATO
MACHADO, MATHEUS ANDRADE RAJÃO, RODRIGO RIBEIRO RESENDE, CARLA
JEANE AGUIAR, ELAINE MARIA DE SOUZA FAGUNDES, CARLOS LEOMAR ZANI,
OLINDO ASSIS MARTINS FILHO, MARIA DE FÁTIMA LEITE
B-2
EVALUATION OF GENOTOXICITY OF SOLANUM LYCOCARPUM
AQUEOUS EXTRACTS UTILIZING ALLIUM CEPA TEST-SYSTEM. VIVIANE MOREIRA
DE LIMA, JÉSSICA TAMARA DOS SANTOS, JENNIFER VIEIRA GOMES, MARIANA DA
SILVA DE MELLO, PATRÍCIA FAMPA, HÉLCIO RESENDE BORBA
B-3
ASSOCIATION BNP LEVEL WITH CARDIAC DAMAGES INDUCED BY
IONIZING RADIATION AND CHEMOTHERAPY DRUGS. VERA MARIA ARAÚJO DE
CAMPOS, CAMILA SALATA, CHERLEY BORBA VIEIRA DE ANDRADE, SAMARA
CRISTINA FERREIRA MACHADO, ADENILSON DE SOUZA DA FONSECA, ANA LUCIA
ROSA NASCIMENTO, JORGE JOSÉ DE CARVALHO, CARLOS EDUARDO VELOSO DE
ALMEIDA
B-4
TRICHOSTATIN A, A HISTONE DEACETYLASE INHIBITOR, AFFECTS
GLIOMA TUMORSPHERES FORMATION AND GROWTH. FELIPE DE ALMEIDA SASSI,
ANA LUCIA ABUJAMRA, RAFAEL ROESLER
B-5
SUPPRESSION OF CLAUDIN-7 EXPRESSION PROMOTES CELL
PROLIFERATION AND DISRUPTS CELL-MATRIX INTERACTIONS IN HUMAN LUNG
CANCER CELLS. ZHE LU, QUN LU, LEI DING, YAN-HUA CHEN
B-6
MODULATION OF CANONICAL WNT SIGNALING PATHWAY
DURING EXPERIMENTAL ORAL CARCINOGENESIS. JULIANA GONÇALVES
CARVALHO, JULIANA NOGUTI, CAROLINA PRADO DE FRANÇA CARVALHO,
MARCELLO FRANCO, CELINA TIZUKO FUJIYAMA OSHIMA, DANIEL ARAKI RIBEIRO
B-7
SCREENING OF PLANTS EXTRACTS OF CERRADO IN NOT CLINICAL
ASSAYS FOR ANTITUMOR ACTIVITY. CAMILA RAQUEL RODRIGUES BARBOSA,
HELOÍSA HELENA MARQUES OLIVEIRA, LUCIANA MARIA SILVA, VERA LÚCIA DE
ALMEIDA, CAROLINA PAULA DE SOUZA MOREIRA
B-8
PRELIMINARY STUDIES
OF PROSTATE TUMOR CELLS
INTERACTIONS WITH BRAIN MICROENVIRONMENT. ELIANE GOUVEA DE
OLIVEIRA, ANTONIO PALUMBO JUNIOR, CELIA YELIMAR PALMERO, LEANDRO
MIRANDA-ALVES, CHRISTINA MAEDA TAKIYA, VIVALDO MOURA-NETO, LUIZ
EURICO NASCIUTTI
B-9
RAF KINASE INHIBITOR (RKIP) DEPLETION IS ASSOCIATED WITH
CERVICAL CANCER AGGRESSIVENESS. OLGA CATARINA LOPES MARTINHO, FILIPE
PINTO, SARA GRANJA, VERA MIRANDA-GONÇALVES, MARISE A.R. MOREIRA, LUIS
F.J. RIBEIRO, CELSO DI LORETO, MARSHA R. ROSNER, ADHEMAR LONGATTO-FILHO,
RUI MANUEL REIS
B - 10
IDENTIFICATION OF NOVEL POTENTIAL PREDICTIVE TARGETS TO
ANTI-ANGIOGENIC THERAPY RESPONSE IN GLIOBLASTOMAS. OLGA CATARINA
LOPES MARTINHO, VERA MIRANDA-GONÇALVES, RUI MANUEL REIS
B - 11
IMMUNOHISTOCHEMICAL EXPRESSION OF BETA-CATENIN, WNT-1
AND C-MYC IN BASAL CELL ADENOMAS FROM SALIVARY GLAND. JOÃO PAULO
SILVA SERVATO, ADRIANO MOTA LOYOLA, ANA LÚCIA AMARAL EISENBERG,
FERNANDO LUIZ DIAS, PAULO ROGÉRIO DE FARIA, SÉRGIO VITORINO CARDOSO
B - 12
CITOTOXICITY BY SELENIUM IN LUNG ADENOCARCINOMA CELLS.
LUDMILLA REGINA DE SOUZA DAVID, MAYARA SIMONELLY COSTA DOS SANTOS,
MARÍLIA CRISTINA ROSA DA COSTA, LUIS ALEXANDRE MUEHLMANN, RICARDO
BENTES DE AZEVEDO, SÔNIA NAIR BÁO
90
B - 13
ANTITUMORAL POTENTIAL ABILITY OF EXTRACELLULAR ATP
AGAINST LEUKEMIC STEM CELLS. ANTONIO CARLOS RIBEIRO FILHO, EDGAR
JULIAN PAREDES GAMERO, CHRISTIANO MARCELO VAZ BARBOSA, AMANDA
NOGUEIRA PEDRO
B - 14
CARDIAC ALTERATIONS INDUCED BY DOCETAXEL AND
CYCLOPHOSPHAMIDE. VERA MARIA ARAÚJO DE CAMPOS, SAMARA CRISTINA
FERREIRA-MACHADO, CAMILA SALATA, CAMILA SALATA, NAZARETH NOVAES
ROCHA, CARLOS ALBERTO MANDARIM-DE-LACERDA, CARLOS EDUARDO
DEALMEIDA
B -15
CELL DEATH INDUCED BY RHODIUM (II) CITRATE LOADED
MAGNETIC NANOPARTICLES IN BREAST CANCER CELLS. NATALIA LEMOS CHAVES,
JOSÉ RAIMUNDO CORRÊA, MARCELLA LEMOS BRETAS, APARECIDO RIBEIRO DE
SOUZA, SÔNIA NAIR BÁO
B -16
LOW-INTENSITY INFRARED LASER EXPOSURE ALTERS EXPRESSION
OF DNA REPAIR GENES. ADENILSON DE SOUZA DA FONSECA, VERA MARIA
ARAÚJO DE CAMPOS, SAMARA CRISTINA FERREIRA-MACHADO, ANTÔNIO
AUGUSTO DE FREITAS PEREGRINO, CARLOS EDUARDO VELOSO DE ALMEIDA,
ANDRÉ LUIZ MENCALHA, MAURO GELLER, FLÁVIA DE PAOLI
B -17
CASPASE-3 ACTIVATION AND INCREASED PROCOLLAGEN TYPE I IN
RADIATION HEART INDUCED LATE EFFECTS. SAMARA CRISTINA FERREIRAMACHADO, CAMILA SALATA, NAZARETH DE NOVAES ROCHA, ALEXANDRE FELIPE
SILVA CORRÊA, SUZANA CÔRTE-REAL FARIA, VERA MARIA ARAÚJO DE CAMPOS,
CHERLEY BORBA VIEIRA DE ANDRADE, ANTÔNIO AUGUSTO DE FREITAS
PEREGRINO, ADENILSON DE SOUZA DA FONSECA, FLÁVIA DE PAOLI, CARLOS
EDUARDO DEALMEIDA
B - 18
ACTIVATED WNT SIGNALING PATHWAY IS NOT INFLUENCED BY
ABSENCE OF GALECTIN-3 IN MICE DURING TONGUE MALIGNANT
TRANSFORMATION. MARCUS VINÍCIUS RODRIGUES DE SOUZA, MONICA LUIZA
CAMARGOS LOPES, WANDERSON DE ALMEIDA RAMOS, ROGER CHAMMAS,
JULIANA MOREIRA DE ALMEIDA SANT’ANA, DANIELLA FERNANDES MENDONÇA,
ADRIANO MOTA LOYOLA, SÉRGIO VITORINO CARDOSO, PAULO ROGÉRIO DE FARIA
B - 19
ESTABLISHMENT OF PRIMARY GLIOBLASTOMA CELL CULTURES
FOR NEW TREATMENT APPROACHES SCREENING. RENATO JOSÉ DA SILVA
OLIVEIRA, OLGA MARTINHO, CARLOS CLARA, JOSÉ REYNALDO ALMEIDA, RUI
MANUEL REIS
B - 20
DNA REPAIR ENZYMES ON PLASMIDS EXPOSED TO LOW-INTENSITY
INFRARED LASER. KEILA DA SILVA CANUTO, ROBERTA DA SILVA MARCIANO, LUIZ
PHELIPPE DA SILVA SERGIO, OSCAR ROBERTO GUIMARÃES, GIOVANNI AUGUSTO
CASTANHEIRA POLIGNANO, MAURO GELLER, FLAVIA DE PAOLI, ADENILSON DE
SOUZA DA FONSECA
B - 21
CELLULAR BEHAVIOR OF PROSTATE CANCER IN AN
INFLAMMATORY MICROENVIRONMENT. AMADO ALFREDO QUINTAR, CAROLINA
LEIMGRUBER, MARIANA MACCIONI, ANDREAS DOLL, CRISTINA ALICIA
MALDONADO
B - 22
ANTITUMOR EFFECT OF RHODIUM(II) CITRATE-LOADED MAGNETIC
NANOPARTICLES IN MICE BEARING BREAST CANCER. SÔNIA NAIR BÁO, ANA
LUISA MIRANDA VILELA, RICARDO GUIRELLI SIMÕES DE OLIVEIRA, LUÍS AUGUSTO
M. TELLES, SÔNIA NAIR BÁO
B - 23
RESVERATROL AND QUERCETIN INDUCE SENESCENCE-LIKE
GROWTH ARREST IN GLIOMA CELLS BY INCREASING DNA DAMAGE. LAUREN
LUCIA ZAMIN, EDUARDO C. FILIPPI-CHIELA, ALESSANDRA PELEGRINI, CHRISTIANNE
SALBEGO, GUIDO LENZ
B -24
ANALYSIS OF THE CYTOTOXIC POTENTIAL OF JUÇARA EXTRACTS
(EUTERPE OLERACEA MART.) IN HUMAN MALIGNANT CELLS. DULCELENA
FERREIRA SILVA, MARIA DO DESTERRO SOARES BRANDÃO NASCIMENTO, FLÁVIA
CASTELLO BRANCO VIDAL, JOSÉ ANDRÉS MORGADO DÍAZ, SIMONE FERNANDES,
PRISCILA DANTAS, DÉBORA SANTOS, MARIA CÉLIA PIRES COSTA, WALBERT EDSON
MUNIZ FILHO, ROBERTO SOARES DE MOURA
B - 25
MYOSIN II EXPRESSION AND REGULATION ON ORAL SQUAMOUS
CELL CARCINOMA. OTÁVIO FRANCISCO GOMES DIAS, BERNARDO SALIM SILVEIRA,
ALESSANDRA MAGNUSSON, ISABEL DA SILVA LAUXEN, MANOEL SANT'ANA FILHO,
MARCELO LAZZARON LAMERS
B - 26
FINASTERIDE TREATMENT DOWNREGULATES FIBRONECTININDUCED MMP-2 AND MMP-9 ACTIVITIES IN HUMAN PROSTATIC EPITHELIAL
CELLS. ANDREI MOROZ, FLAVIA KARINA DELELLA, ELENICE DEFFUNE, SÉRGIO LUIS
FELISBINO
B - 27
IN VITRO ANTITUMOR ACTIVITY OF EXTRACTS FROM ENDOPHYTIC
FUNGI ASSOCIATED WITH CLUSIA SP. ANTONIO CESAR CORRÊA SILVA FILHO, LUIZ
HENRIQUE ROSA, LUCIANA MARIA SILVA
B - 28
CYTOTOXIC ACTIVITY OF PYRANONAPHTHOQUINONES AGAINST
TWO DIFFERENT LEUKEMIA CELL LINES. PATRÍCIA CRISTINA RODRIGUES, SABRINA
BAPTISTA FERREIRA, VITOR FRANCISCO FERREIRA, FLORIANO PAES SILVA JUNIOR
B - 29
INTRACELLULAR OXIDATIVE STRESS IS ASSOCIATED WITH NONSMALL CELL LUNG CANCER HUMAN CELL LINES AGGRESSIVENESS. FERNANDA
STAPENHORST FRANÇA, LEONARDO LISBOA MOTTA, JULIANE BORBA MINOTTO,
MATHEUS BECKER FREITAS, GUILHERME ANTÔNIO BEHR, ALFEU ZANOTTO-FILHO,
MELISSA MEDEIROS MARKOSKI, JOSÉ CLÁUDIO FONSECA MOREIRA, FÁBIO KLAMT
B - 30
SUPEROXIDE ANION MODULATES DNMT1 LEVELS VIA
RAS/MEK/ERK
PATHWAY
DURING
MELANOCYTE
MALIGNANT
TRANSFORMATION ASSOCIATED WITH SUSTAINED STRESS CONDITION.
FERNANDA MOLOGNONI, FABIANA HENRIQUES MACHADO DE MELO, TIAGO
FRANCO DE OLIVEIRA, ANA PAULA DE MELO LOUREIRO, MIRIAM GALVONAS
JASIULIONIS
B - 31
LOW-INTENSITY RED LASER DEACRESES SURVIVAL OF PLASMIDS IN
ESCHERICHIA COLI PROFICIENT AND DEFICIENT ON DNA REPAIR CELLS. ROBERTA
DA SILVA MARCIANO, LUIZ PHILIPPE DA SILVA SERGIO, OSCAR ROBERTO
GUIMARÃES, GIOVANNI AUGUSTO CASTANHEIRA POLIGNANO, MAURO GELLER,
FLAVIA DE PAOLI, ADENILSON DE SOUZA DA FONSECA
B - 32
HPV INFECTION CORRELATION IN THE PATHOGENESIS OF
CERVICAL CANCER. KEILA ALVES DA SILVA, SORAYA LOBATO, ANNAMARIA
RAVARA VAGO
B - 33
IN VITRO ANTITUMOR ACTIVITY OF SYNTHETIC SCHIFF BASES IN
HUMAN CELL LINES. MARIANA DE PAULA LAZAROTTI, JOSIANE BARBOSA PIEDADE,
CLEITON MOREIRA DA SILVA, LEANDRO NUNES SAMPAIO, ANGELO DE FÁTIMA,
LUCIANA MARIA SILVA
B - 34
CYTOTOXICITY OF SYNTHETIC ANALOGS OF VISCOSALINE AND
THEONELLADIN C. JULIANA REY CANUTO SANT”ANA PEREIRA, ALINE BRITO DE
LIMA, GUSTAVO HENRIQUE RIBEIRO VIANA, LUCIANA MARIA SILVA, FERNANDO DE
PILLA VAROTTI
B - 35
THE ROLE OF GPC3 IN CELL PROLIFERATION IN CELL LINES OF
RENAL CARCINOMA. MARINA CURADO VALSECHI, ANA BEATRIZ BORTOLOZO DE
OLIVEIRA, MARÍLIA DE FREITAS CALMON, PAULA RAHAL
B - 36
BIOLOGICAL EFFECTS OF MAGNETIC NANOPARTICLES: STUDIES IN
VITRO AND IN VIVO FOR POTENTIAL STRATEGIES IN ORAL CARCINOMA. NATALIA
MARIA CANDIDO, MARILIA DE FREITAS CALMON, ARYANE TOFANELLO SOUZA,
SEBASTIÃO ROBERTO TABOGA, JOSÉ GERALDO NERY, PAULA RAHAL
B - 37
ANTI-MRP1 ACTIVITY OF 3B-ACETYL TORMENTIC ACID, A
PENTACICLIC TRITERPENE FROM CECROPIA LYRATILOBA. GLEICE DA GRAÇA
ROCHA, RODRIGO RODRIGUES DE OLIVEIRA, MARIA A.C. KAPLAN, CERLI ROCHA
GATTASS
B - 38
ANTITUMOR ACTIVITY OF POMOLIC ACID IN GLIOBLASTOMA
MULTIFORME CELL LINE. LÍVIA PAES TAVARES PACHECO GUIMARÃES, CERLI
ROCHA GATTASS
B - 39
EPITHELIAL-MESENCHYMAL TRANSITION IN CERVIX CARCINOMA:
DONWREGULATION OF E-CADHERIN IN INVASION FRONT. PRISCILA SAMARA
SARAN, SILVIA VANESSA LOURENÇO, CLÁUDIA MALHEIROS COUTINHO-CAMILLO,
FERNANDO AUGUSTO SOARES
B - 40
TUMORSPHERE GROWTH AND CANCER STEM CELL POPULATION
ARE REDUCED BY EXTRACELLULAR ATP IN GLIOBLASTOMA CELLS. PÍTIA FLORES
LEDUR, EMILLY SCHLEE VILLODRE, GUIDO LENZ
B - 41
ANTI-INFLAMMATORY PROTEIN ANNEXIN-1 AND FORMYL PEPTIDE
RECEPTOR-2 AS THERAPEUTIC TARGETS FOR HUMAN LARYNX CANCER. THAÍS
SANTANA GASTARDELO, LUCAS RIBEIRO DE AZEVEDO, FLÁVIA CRISTINA
RODRIGUES LISONI, BIANCA DA CUNHA RODRIGUES, ELOIZA HELENA SILVA
TAJARA, SÉRGIO LUIS RAPOSO, JOSÉ VICTOR MANIGLIA, PATRÍCIA MALUF CURY,
SONIA MARIA OLIANI
B - 42
EVALUATION OF LANGERHANS CELLS DENSITY AND HPV
INFECTION IN CERVICAL SQUAMOUS INTRAEPITHELIAL LESIONS AND INVASIVE
CANCER. DANIELE DE SOUZA CAMARGOS, ALEXANDRE TAFURI, PAULA ÁVILA
FERNANDES, MARCELO VIDIGAL CALLIARI, MARCOS XAVIER SILVA, ANNAMARIA
RAVARA VAGO
B - 43
CELLULAR
PRION-HEAT-SHOCK
ORGANIZING
PROTEIN
INTERACTION AS A NOVEL THERAPEUTIC TARGET FOR GLIOBLASTOMAS. LOPES,
M.H, QUEIROZ-HAZARBASSANOV N.G.T, RODRIGUES, B. R., SANTOS, T. G., CUNHA
I.W., OBA-SHINJO, S.M, MARIE, S.K.N., MARTINS, V.R.
B - 44
COMPARATIVE ANTITUMOR EFFECT OF DIGITALIS ON CERVIX AND
COLON CANCER CELL LINES. SAYONARAH CARVALHO ROCHA, LUIZA DAL-RIOS
NEVES, MARCO TULIO CORREA PESSOA, SILMARA LUCIA GREGO ALVES, ISABELLA
VIANA SILVA, LUCIANA MARIA DA SILVA, JOSÉ AUGUSTO FP VILLAR, FABIO VIEIRA
DOS SANTOS, FERNANDO DE PILLA VAROTTI, LEANDRO AUGUSTO BARBOSA
B - 45
THE INFLUENCE OF O-GLCNACYLATION IN THE MOTILITY OF
ALVEOLAR EPHITHELIAL CANCER CELLS. JOANA LAUREANO DONADIO, ANA CLARA
BRANDÃO MEDINA DOLHER SOUZA, PATRÍCIA DE CARVALHO CRUZ, LEONARDO
FREIRE-DE-LIMA, ADRIANE REGINA TODESCHINI, WAGNER BARBOSA DIAS
B - 46
GENETICS OF GLIOMA-ROLE OF A RNA BINDING PROTEIN IN
MALIGNANCY. KUMAR SOMASUNDARAM
B - 47
ANTINEOPLASTIC EFFECT OF TWO DIFFERENT APPROACHES OF
LQB-118 ADMINISTRATION IN MURINE MELANOMA MODEL. EDUARDO
SALUSTIANO JESUS DOS SANTOS, GABRIEL GONÇALVES DA SILVA SANTOS,
MATHEUS LOURENÇO DUMAS, ALCIDES JOSÉ MONTEIRO DA SILVA, PAULO
ROBERTO RIBEIRO COSTA, VIVIAN MARY BARRAL DODD RUMJANEK
91
B -48
LECTIN OBTAINED OF CAULIFLOWER (BRASSICA OLERACEA VAR.
BOTRITYS) INHIBITS PROLIFERATION OF CELL LINEAGE OF BREAST CANCER.
MONISE VIANA ABRANCHES, LORENA NACIF MARÇAL, NATÁLIA CRISTINA SANTOS
COSTA, SÍLVIA ALMEIDA CARDOSO, SÉRGIO OLIVEIRA DE PAULA, LEANDRO LICURSI
DE OLIVEIRA
B - 49
EFFECT OF EPIGENETIC DRUGS IN ANTI-HORMONAL TREATMENT
OF BREAST TUMOR CELL LINES. DANIELA FILIPPINI IERARDI, GIMENA AGUIAR,
MIRIAM GALVONAS JASIULIONIS
B - 50
SURVIVAL PROGENY DERIVED FROM IRRADIATED PARENTAL
COLORECTAL CANCER CELLS: MORFOLOGICAL AND FUNCTIONAL ANALYSIS.
PRISCILA GUIMARÃES DE MARCONDES, LÍLIAN GONÇALVES BASTOS, JOSÉ ANDRÉS
MORGADO DÌAZ
B - 51
ANALYSIS OF CLASSIC CADHERINS EXPRESSION IN A MURINE
MELANOMA MODEL. LORENA NACIF MARÇAL, ROSEMAIRY LUCIANE MENDES,
MARCELO LOBATO MARTINS, ADILSON ARIZA ZACARO
B - 52
RETINOBLASTOMA (RB) PROTEIN KNOCK-DOWN INCREASES
APOPTOSIS AND REDUCES ACID VESICLES FORMATION IN GLIOBLASTOMA
ETOPOSIDE TREATED CELLS. DEBORAH BIASOLI, SUZANA ASSAD KHAN, TAIS
AZEVEDO, VIVALDO MOURA-NETO, HELENA LOBO BORGES
B - 53
TRANSGLUTAMINASE 2 ACTIVATES BOTH CASPASE-DEPENDENT
AND CASPASE-INDEPENDENT APOPTOTIC CELL DEATH VIA CALPAIN/BAX
SIGNALING PATHWAY IN RESPONSE TO PHOTODYNAMIC THERAPY. JE-OK YOO,
YOUNG-CHEOL LIM, YOUNG-MYEONG KIM, KWON SOO HA
B - 54
MINICHROMOSOME MAINTENANCE 7 PROTEIN IS A RELIABLE
BIOLOGICAL MARKER FOR HUMAN CERVICAL PROGRESSIVE DISEASE. SORAYA
LOBATO, ALEXANDRE TAFURI, PAULA ÁVILA FERNANDES, MARCELO VIDIGAL
CALIARI, MARCOS XAVIER SILVA, MARCELO ANTÔNIO PASCOAL XAVIER,
ANNAMARIA RAVARA VAGO
B - 55
IMMUNOMODULATORY AND ANTINEOPLASTIC EFFECT OF LQB118, A PTEROCARPANOQUINONE, IN VIVO. VIVIAN MARY BARRAL DODD
RUMJANEK, EDUARDO SALUSTIANO JESUS DOS SANTOS, ALCIDES JOSE MONTEIRO
DA SILVA, PAULO ROBERTO RIBEIRO COSTA, VIVIAN MARY BARRAL DODD
RUMJANEK
B - 56
TARGETING METNASE TO ENHANCE CHEMOTHERAPY. ANDREI
LEITÃO, ELIZABETH A. WILLIAMSON, LEAH DAMIANI, CHELIN HU, HELEN
HATHAWAY, TUDOR I. OPREA, LARRY SKLAR, MONTASER SHAHEEN, JULIE
BAUMAN, WEI WANG, JAC A. NICKOLOFF, SUK-HEE LEE, ROBERT HROMAS
B - 57
THE ROLE OF GLUTAMINASE-INTERACTING PROTEIN AND LIVERTYPE GLUTAMINASE ASSOCIATION ON CELL REDOX HOMEOSTASIS. ROBERTA
CASAGRANDE SAEZ, KALIANDRA DE ALMEIDA GONÇALVES, SANDRA MARTHA
GOMES DIAS
B - 58
VEGFR-3 EXPRESSION IN CERVICAL CARCINOMA AS A BIOMARKER
OF TUMOR RESPONSE TO RADIOCHEMOTHERAPY. IOANA-CARMEN BRIE,
VIORICA NAGY, NICOLAE TODOR, RARES BUIGA, OVIDIU BALACESCU, LUMINITA
LELUTIU, CLAUDIA ORDEANU, EVA FISCHER-FODOR
B - 59
CALLUNA VULGARIS INDUCES APOPTOSIS AND INHIBITS INVASION
IN A431 HIGHLY METASTATIC EPIDERMOID CARCINOMA CELL LINE. MARIA
PERDE-SCHREPLER, EVA FISCHER FODOR, CORINA TATOMIR, TIBOR KRAUSZ, CALIN
PRECUP
B - 60
EFFECT OF THE COMPOUND A2CN ON THE CYTOTOXITY IN
LEUKEMIC CELL LINES. CAIO CÉSAR BARBOSA BOMFIM, GLÁUCIA VERÍSSIMO
FAHEINA MARTINS, BRUNA BRAGA DANTAS, ALETHÉIA LACERDA DA SILVEIRA,
CLAUDIO GABRIEL LIMA JUNIOR, MÁRIO LUIZ ARAUJO DE ALMEIDA
VASCONCELLOS, DEMETRIUS ANTONIO MACHADO DE ARAÚJO
B - 61
IDENTIFICATION OF NOVEL MOLECULAR MARKERS IN HUMAN
GLIOBLASTOMA WITH THERAPEUTIC POTENTIAL. LAURA BEATRIZ DA SILVA
CARDEAL, ALINNE LE FOSSE, JUSSARA MICHALOSKI, RAFAEL MALAGOLI, RICARDO
JOSE GIORDANO
B -66
LYCOPENE AND BETA-CAROTENE INDUCE GROWTH-INHIBITORY
AND PROAPOPTOTIC EFFECTS ON PITUITARY TUMOR CELLS. NATÁLIA FERREIRA
HADDAD, ANDERSON JUNGER TEODORO, FELIPE LEITE DE OLIVEIRA, NATHÁLIA
SOARES, RÔMULO MEDINA DE MATTOS, RÔMULO DEZONNE, FLÁVIA C.
ALCÂNTARA GOMES, MÔNICA ROBERTO GADELHA, LUIZ EURICO NASCIUTTI,
LEANDRO MIRANDA-ALVES
B - 67
EFFECT FROM A POLYSACHARIDE FROM SARGASSUM VULGARE IN
ENDOTHELIAL AND TUMORAL CELL LINES: A NEW STRATEGY FOR ANTITUMOR
AND ANTIANGIOGENIC. CELINA MARIA PINTO GUERRA DORE, MONIQUE
GABRIELA DAS CHAGAS FAUSTINO ALVES, TIAGO GOMES COSTA, MARÍLIA SILVA
DO NASCIMENTO, HUGO WESCLEY BARROS ALMEIDA, ALMINO AFONSO DE
OLIVEIRA PAIVA, LUCIANA GUIMARÃES ALVESFILGUEIRA, EDDA LISBOA LEITE
B - 68
EGF MODULATES CLAUDIN EXPRESSION INCREASING THE
TUMORIGENIC POTENTIAL IN COLORECTAL CANCER CELLS. NATALIA FORTUNATO
DE MIRANDA, WALDEMIR FERNANDES DE SOUZA, BRUNO KAUFMANN ROBBS,
JOÃO PAULO DE BIASO VIOLA, JOSÉ ANDRÉS MORGADO DÍAZ
B - 69
SHH
SIGNALING
PATHWAY
IN
MODULATING
GBM
PROLIFERATION. TANIA CRISTINA LEITE DE SAMPAIO E SPOHR, INGRID
ROSENBURG CORDEIRO, JOSÉ MARQUES BRITO NETO, VIVALDO MOURA NETO
B - 70
DIFFERENTIALLY EXPRESSED STEM CELL MARKERS IN BREAST
CANCER STEM CELLS. ALINE RAMOS MAIA LOBBA, MARIA FERNANDA FORNI, ANA
CLAUDIA OLIVEIRA CARREIRA, MARI CLEIDE SOGAYAR
B - 71
ROLES OF NUP98 IN GENE EXPRESSION REGULATION AND ITS
LINKS TO CARCINOGENESIS. JULIANA S. CAPITANIO, RICHARD W. WOZNIAK
B - 72
IN VITRO ANTICANCER ACTIVITY OF N-GLYCAN BIOSYNTHESIS
INHIBITORS IN COLORECTAL CANCER CELLS. CARLOS ALBERTO FREIRE NETO,
JULIO CESAR MADUREIRA DE FREITAS JUNIOR, JOSÉ ANDRES MORGADO-DÍAZ
B - 73
SEX HORMONES EFFECTS ON ADAMTS-1 LEVELS IN NORMAL AND
TUMORAL BREAST CELLS. SUÉLY VIEIRA DA SILVA, SHEILA CRISTINA ROSAS DE
ARGÔLO, EMERSON SANTOS, VANESSA MORAIS FREITAS
B - 74
LAMININ-DERIVED PEPTIDES C16 AND AG73 REGULATE
EXPRESSION LEVELS OF SPOCK-1 AND MT1-MMP IN BREAST CANCER CELLS.
BASILIO SMUCZEK, EMERSON DE SOUZA SANTOS, VANESSA M. DE FREITAS, RUY
GASTALDONI JAEGER
B - 75
IDENTIFICATION OF CRUDE EXTRACT MOLECULES FROM BEANS
INVOLVED IN SKIN CANCER PREVENTION. GRAZIELLA ANSELMO JOANITTI,
EDUARDO FERNANDES BARBOSA, LUCIANO PAULINO SILVA, RICARDO BENTES
AZEVEDO, SONIA MARIA DE FREITAS
B - 76
PTEN OVEREXPRESSION REVERTS THE MALIGNANT PHENOTYPE OF
COLORECTAL CANCER CELLS IN AN EVENT MEDIATED BY THE WNT/B-CATENIN
PATHWAY. WALLACE MARTINS DE ARAÚJO, PEDRO DANIEL SILVA DE MORAES,
BRUNO KAUFMANN ROBBS, JOÃO PAULO DE BIASO VIOLA, JOSÉ ANDRES
MORGADO-DÍAZ
B - 77
EFFECTS OF HCG AND DERIVETED-ANGIOTENSIN PEPTIDES ON CELL
VIABILITY AND APOPTOSIS IN TUMORAL (MCF-7) AND NORMAL (MCF10A)
EPITHELIAL BREAST CELLS. CORREA-NORONHA, SAA, NORONHA, SMR,
ROZENCHAN, PB, BERNARDO, W, SHIMUTA, SI, NAKAIE, CR, GEBRIM, LH, NAZARIO,
ACP, SILVA, IDCG
B - 78
ATYPICAL FUNCTIONS OF THE CELL CYCLE INHIBITOR
P21WAF1/CIP1: A POSSIBLE ROLE IN SURVIVAL OF MELANOMA CELLS. GABRIELA
NANA COLANERI, ADRIANA TAVEIRA DA CRUZ, ROBERTA SESSA STILHANO, SANG
WON HAN, MIRIAM GALVONAS JASIULIONIS
B - 79
LPA INDUCES CELL PROLIFERATION THROUGH A RHO-ROCK
SIGNALING IN HCT-116 CELLS. RUBEM JOSÉ PERES MOREIRA, FERNANDA LEVE,
JOSÉ ANDRÉS MORGADO-DÍAZ
B - 80
STEPS TOWARD NOVEL ANTI-VEGF THERAPEUTIC AGENTS.
JUSSARA MICHALOSKI SOUZA, RICARDO JOSÉ GIORDANO
B - 62
A CASE OF DISSEMINATED NEOPLASIA IN MANGROVE OYSTERS
CRASSOSTREA GASAR. NATANAEL DANTAS FARIAS, FERNANDO RAMOS
QUEIROGA, HELENE HÉGARET, PHILIPPE SOUDANT, LUIS FERNANDO MARQUES
SANTOS, PATRÍCIA MIRELLA DA SILVA SCARDUA
B - 81
DIFFERENTIAL PROTEINS EXPRESSION IN CANCER CELL LINES
SKBR3 AND MCF-7 BY 17 BETA-ESTRADIOL (E2), ICI 182,780 AND G1. MILENE
SCHMIDT LUNA, ANDRÉIA DE SOUZA, CINTIA SCUCUGLIA HELUANY, CATARINA
SEGRETI PORTO, NORMA YAMANOUYE
B - 63
MORPHOLOGICAL FEATURES OF THE MELANOMA B16F10 AND
B16F0 CELL LINES AND TUMORS. JULIANNA MARIA DA CUNHA DE OLIVEIRA
SANTOS, EULÓGIO CARLOS CARVALHO, FÁBIO LOPES OLIVARES, WILLIAM
RODRIGUES FREITAS, LAYLA JANAÍNA HISSA BORGES, MILTON KANASHIRO, LUIS
OTTONIEL LATORRE, CAMILA CRUZ RIBEIRO, ARNOLDO ROCHA FAÇANHA
B - 82
APOPTOSIS INDUCTION BY PHORBOL ESTER-RESPONSIVE PKC
ISOFORMS IN HUMAN EMBRYONIC KIDNEY CELL LINES (HEK 293) DISPLAYING A
RAS-DEPENDENT MALIGNANT PHENOTYPE. JULIANA GALVÃO DA SILVA, HUGO
AGUIRRE ARMELIN
B - 64
IN VITRO STUDY OF ASSOCIATION OF NATURAL COMPOUNDS AND
CHEMOTHERAPY. AMANDA VALLE PINHATTI, ANA ABUJAMRA, FRANCISCO
MAIKON CORRÊA DE BARROS, CAROLINE FARIAS BRUNETTO, GILBERTO
SCHWARTSMANN, GILSANE VON POSER
B - 65
CYTOPLASMIC DISTRIBUTION OF KAISO IN BLAST CRISIS OF
CHRONIC MYELOID LEUKEMIA. GREYCE CHRISTINE LISBOA BUENO, JAIME COFRE,
PIETRO LENTZ MARTINS CANTÚ, JOÃO RICARDO LACERDA DE MENEZES, ELIANA
ABDELHAY, LUCIANA PIZZATTI
B - 83
THE EFFECT IN VITRO OF ANTI-INFLAMMATORY PROTEIN ANNEXIN
A1 ON TUBULOGENESIS AND CELL ADHESION. JÉSSICA ZANI LACERDA, THAÍS
SANTANA GASTARDELO, CARINE CRISTIANE DREWES, SANDRA HELENA POLISELLI
FARSKY, SONIA MARIA OLIANI
B - 84
EVALUATION OF CELL ADHESION IN BREAST AND LARYNGEAL
CANCER CELLS WITH PHOTODYNAMIC THERAPY. GEISA NOGUEIRA SALLES,
JULIANA MACEDO COSTA COUCEIRO, CRISTINA PACHECO SOARES
92
B - 85
CONDITIONED MEDIA FROM EPITHELIAL OVARIAN CANCER CELL
LINES CHRONICALLY EXPOSED TO CISPLATIN IS CAPABLE OF INDUCING
APOPTOSIS IN NAIVE CELLS. ALICE LASCHUK HERLINGER, CELSO CARUSO NEVES,
LETICIA BATISTA AZEVEDO RANGEL
B - 86
SUPER-EXPRESSION OF RAS AND SILENCE OF SYNDECAN-4 IS
RELATED WITH TUMORIGENESIS. RENAN PELLUZZI CAVALHEIRO, THAIS RUEGGER
JARROUGE-BOUÇAS, RODRIGO IPPOLITO BOUÇAS, GABRIEL LOPES ARGELLO
CUNHA, VIVIEN JANE COULSON-THOMAS, TARSIS GESTEIRA FERREIRA, EDUARDO
HENRIQUE CUNHA DE FARIAS, MARCELO ANDRADE DE LIMA, EDVALDO DA SILVA
TRINDADE, EDGAR JULIAN PAREDES-GAMERO, JULIANA LUPORINI DREYFUSS,
CARLA CRISTINA LOPES DE AZEVEDO, HELENA BONCIANI NADER
LÍVIA CARVALHO FERREIRA, JULIANA RAMOS LOPES, MARINA GOBBE MOSCHETTA,
DEBORA AP. PIRES DE CAMPOS ZUCCARI
B - 102
TESTING PHAGE CLONES FOR IMPROVE THYROID CANCER
DIAGNOSTIC. CAROLINA FERNANDES REIS, PATRICIA TIEME FUJIMURA, FABIANA
DE ALMEIDA ARAÚJO SANTOS, JOÃO PAULO BORGES, CARLOS UEIRA VIEIRA, LUIZ
RICARDO GOULART, LAURA STERIAN WARD
B - 103
POTENTIAL PROGNOSTIC VALUE OF CA 15-3 IN MAMMARY
CANCER. GABRIELA BOTTARO GELALETI, CAMILA LEONEL, MARINA GOBBE
MOSCHETTA, BRUNA VICTORASSO JARDIM, LARISSA BAZELA MASCHIO, LÍVIA
CARVALHO FERREIRA, JULIANA RAMOS LOPES, THAIZ FERRAZ BORIN, NAIANE DO
NASCIMENTO GONÇALVES, DEBORA APARECIDA PIRES DE CAMPOS ZUCCARI
B - 87
ATP - INDUCED CELL DEATH BY P2X7 RECEPTOR IN HUMAN
CERVICAL CARCINOMA CELL LINE. PAOLA DE ANDRADE MELLO, EDUARDO C.
FILIPPI-CHIELA, ALINE BECKENKAMP, DANIELLE SANTANA BERTODO, JESSICA
NASCIMENTO, LUCIANA N. CALIL, EMERSON CASALI, ALESSANDRA NEJAR BRUNO,
JULIANO PACCEZ, LUIZ FERNANDO ZERBINI, MÁRCIA R. WINK, GUIDO LENZ,
ANDRÉIA BUFFON
B - 104
PROLIFERATIVE EFFECTS OF POD1/TCF21 TRANSCRIPTION FACTOR
IN HUMAN ADRENOCORTICAL TUMOR CELL CULTURES. MONICA MALHEIROS
FRANÇA, MARIZA GERDULO SANTOS, BRUNO FERRAZ DE SOUZA, ANTONIO M.
LERARIO, MARIA CANDIDA FRAGOSO, ANA CLAUDIA LATRONICO, BERENICE B.
MENDONÇA, CLAUDIMARA FERINI PACICCO LOTFI
B - 88
PROGRESSION OF HUMAN GLIOBLASTOMA IN THE BRAIN
PARENCHYMA FROM IMMUNOCOMPETENT MICE. CELINA GARCIA DA FONSECA,
LUIZ HENRIQUE MEDEIROS GERALDO, LUIZ GUSTAVO DUBOIS, FERNANDA TOVARMOLL, JOÃO MENEZES, VIVALDO MOURA NETO, FLAVIA REGINA SOUZA LIMA
B - 105
EFFECTS OF BRAZILIAN PALM TREE EXTRACT ON ACTH-SECRETING
MOUSE PITUITARY TUMOR CELLS. FLÁVIA MOSCARDINI, NATALIA FERREIRA
HADDAD, MARIA APARECIDA DE OLIVEIRA DOMINGOS, LÚCIO MENDES CABRAL,
LEANDRO MIRANDA-ALVES, LUIZ EURICO NASCIUTTI
B - 89
HUMAN GLIOBLASTOMA CANCER STEM CELLS ARE SENSITIVE TO
DOXORUBICIN AND TEMOZOLOMIDE. EMILLY SCHLEE VILLODRE, PATRÍCIA
LUCIANA DA COSTA LOPEZ, GUIDO LENZ
B - 106
ROLE OF CANCER STEM CELLS IN GLIOBLASTOMA INVASION OF IN
THE BRAIN PARENCHYMA. FERNANDO DOS SANTOS ASSUNÇÃO, GABRIELA BASILE
CARBALLO, GRASIELLA MARIA VENTURA MATIOSZEK, CHARLES VARGAS LOPES,
CAROLINE MOREIRA, CELINA GARCIA, HERVÉ CHNEIWEISS, ROGERIO ARENA
PANIZZUTTI, SUZANA ASSAD KAHN, VIVALDO MOURA NETO
B - 90
THE ROLE OF P53 IN THE TUMOR-MICROENVIRONMENT
INTERACTION. MORGANA FERREIRA SOBRINHO, DEBORAH BIASOLI, DYANNA
GALAXE DE MATOS, VIVALDO MOURA NETO, HELENA LOBO BORGES, FLAVIA
REGINA SOUZA LIMA
B - 91
BAUHINIA FORFICATA LECTIN (BFL) INDUCES MITOCHONDRIAL
CELL DEATH AND INTEGRIN-MEDIATED ANTI-ADHESION ON MCF-7 HUMAN
BREAST CANCER CELLS. MARIANA CRISTINA CABRAL SILVA, CLÁUDIA ALESSANDRA
ANDRADE DE PAULA, JOANA GASPERAZZO FERREIRA, EDGAR JULIAN PAREDESGAMERO, RODRIGO DA SILVA FERREIRA, MISAKO UEMURA SAMPAIO, MARIA
TEREZA DOS SANTOS CORREIA, MARIA LUIZA VILELA OLIVA
B - 92
MOLECULAR MARKER ANALYSIS IN HEAD AND NECK SQUAMOUS
CELL CARCINOMA. ELAINE STUR, ELDAMÁRIA DE VARGAS WOLFGRAMM, LIDIANE
PIGNATON AGOSTINI, LUCAS LIMA MAIA, LYVIA NEVES REBELLO ALVES, IÚRI
DRUMOND LOURO
B - 93
INCIDENCE OF HUMAN PAPILOMAVIRUS IN HEAD AND NECK
SQUAMOUS CELL CARCINOMA IN ESPIRITO SANTO, BRASIL. LIDIANE PIGNATON
AGOSTINI, MARIANA PENHA DE NADAI SARTORI, ELAINE STUR, ELDAMÁRIA DE
VARGAS WOLFGRAM, IÚRI DRUMOND LOURO
B - 94
PROTECTIVE ACTION IN NORMAL CELLS AND APOPTOSIS IN
HUMAN LIVER CANCER CELLS BY THE PHYLLANTHUS NIRURI DRY EXTRACT.
HUGO GONÇALO GUEDES, JÉSSICA AQUINO VILAÇA, ANA LUIZA CABRAL DE SÁ,
AURIGENA ANTUNES DE ARAÚJO, GERLANE COELHO BERNARDO GUERRA,
RAIMUNDO FERNANDES DE ARAÚJO JÚNIOR
B - 107
C-MYC EXPRESSION IN DYSPLASIAS AND CARCINOMAS
DEVELOPED IN THE TONGUE FROM GALECTIN-3-DEFICIENT AND WILD-TYPE MICE
CHALLENGED BY 4NQO. GUSTAVO JOSÉ DE MORAIS GONÇALVES, WANDERSON
DE ALMEIDA RAMOS, ROGER CHAMMAS, ADRIANO MOTA LOYOLA, SERGIO
VITORINO CARDOSO, PAULO ROGÉRIO DE FARIA
B - 108
DIFFERENTIAL EXPRESSION AND ACTIVITY OF THE CD26/DPPIV IN
HUMAN CERVICAL CARCINOMA CELLS. ALINE BECKENKAMP, DANIELLE BERTODO
SANTANA, JÉSSICA NASCIMENTO, CAROLINE GUERRA MARANGON, JULIANO
PACCEZ, LUIZ FERNANDO ZERBINI, MÁRCIA ROSÂNGELA WINK, ALESSANDRA
NEJAR BRUNO, ANDRÉIA BUFFON
B - 109
PHOSPHATIDIC ACID INCREASED BY LPP INHIBITION INDUCES
LIGAND-INDEPENDENT EGFR ENDOCYTOSIS INVOLVING ACTIVATION OF MAPKS.
CLAUDIA METZ, JUAN JUNG, CAROLINA OTERO, ANDREA SOZA, ALFONSO
GONZÁLEZ
B - 110
REGULATION OF FOCAL ADHESION KINASE ACTIVITY IN ORAL
SQUAMOUS CELL CARCINOMA. BERNARDO SALIM SILVEIRA, OTAVIO FRANCISCO
GOMES DIAS, ALESSANDRA MAGNUSSON, ISABEL DA SILVA LAUXEN, MANOEL
SANT’ANA FILHO, MARCELO LAZZARON LAMERS
B - 111
PHYLLANTHUS NIRURI EXTRACTS AND CISPLATIN HAVE GROWTH
INHIBITORY EFFECTS ON CANCER CELL LINES. JESSICA AQUINO VILAÇA,
RAIMUNDO FERNANDES DE ARAÚJO JÚNIOR
B - 95
PROGNOSTIC EVALUATION OF S100A4 AND P53 IN CERVICAL
CANCER CELLS. JÉSSICA NASCIMENTO, REGINA BIASIBETTI, PATRÍCIA NARDIN,
ALINE BECKENKAMP, DANIELLE BERTODO SANTANA, ALESSANDRA NEJAR BRUNO,
LUCIANE CALIL, MARIA ISABEL A. EDELWEISS, CARLOS ALBERTO GONÇALVES,
ANDRÉIA BUFFON
B - 112
MECHANISMS OF FGF2 TOXICITY IN RAS-DRIVEN MALIGNANT
CELLS: CELL DIVISION BLOCKAGE AND PROTEOTOXIC STRESS. MATHEUS
HENRIQUE DOS SANTOS DIAS, FÁBIO NAKANO, CECÍLIA SELLA FONSECA, ANDRÉ
ZELANIS PALITOT PEREIRA, SOLANGE MARIA DE TOLEDO SERRANO, HUGO
AGUIRRE ARMELIN
B - 96
ROLE OF DLG5 IN PROSTATE CANCER PROGRESSION. LUCIA
TOMIYAMA, TAKUHITO SEZAKI, KAZUMITSU UEDA, NORIYUKI KIOKA
B - 113
EGF PROMOTES CELL MIGRATION IN LUNG CANCER CELL LINES.
CAMILA LAUAND, PAULA REZENDE TEIXEIRA, EVANDRO LUÍS DE OLIVEIRA NIERO,
GLÁUCIA MARIA MACHADO SANTELLI
B - 97
THE ROLE OF LYSOPHOSPHATIDIC ACID IN THE MICROGLIAGLIOBLASTOMA INTERACTION. RACKELE FERREIRA DO AMARAL, TANIA CRISTINA
LEITE DE SAMPAIO E SPOHR, FABIO DE ALMEIDA MENDES, VIVALDO MOURA
NETO, FLAVIA REGINA SOUZA LIMA
B - 98
INTERACTION OF TWO DISINTEGRINS WITH BREAST TUMOR CELLS.
ARACELI CRISTINA DURANTE, LÍVIA MARA SANTOS, HERNANDES FAUSTINO DE
CARVALHO, EDWARD SHAW, CHARLOTTE LEDBETTER OWNBY, HELOÍSA SOBREIRO
SELISTRE-DE-ARAÚJO
B - 99
MOLECULAR CLONING AND EXPRESSION OF ALTERNAGIN-C, A
DISINTEGRIN FROM RHINOCEROPHIS ALTERNATUS VENOM. LIVIA MARA
SANTOS, VERÔNICA ASSALIN ZORGETTO, MÔNICA ROSAS DA COSTA IEMMA,
ARACELI CRISTINA DURANTE, DULCE HELENA FERREIRA DE SOUZA, HELOISA
SOBREIRO SELISTRE DE ARAÚJO
B - 100
EVALUATION OF BREAST CANCER CELL LINES VIABILITY IN
RESPONSE TO TREATMENT WITH MELATONIN. JULIANA RAMOS LOPES, BRUNA
VICTORASSO JARDIM, LARISSA BAZELA MASCHIO, THAIZ FERRAZ BORIN, LÍVIA
CARVALHO FERREIRA, NAIANE DO NASCIMENTO GONÇALVES, CAMILA LEONEL,
MARINA GOBBE MOSCHETTA, GABRIELA BOTTARO GELALETI, DEBORA AP. PIRES
DE CAMPOS ZUCCARI
B - 101
GSH AND GSH-PX EXPRESSION IN PRIMARY CULTURE CELL OF
CANINE MAMMARY TUMORS AFTER EXPOSURE TO DOXORUBICIN. CAMILA
LEONEL DA SILVA, GABRIELA BOTTARO GELALETI, BRUNA VICTORASSO JARDIM,
B - 114
THE
SELECTION
OF
TUBULOGENESIS-DEFECTIVE/HIGHLY
PROLIFERATIVE ENDOTHELIAL CELLS BY TENASCIN-C IN THE EXTRACELLULAR
MATRIX OF GLIOMA CELLS INVOLVES THE OPPOSITE MODULATION OF PKCALPHA AND DELTA ISOFORMS. ALINE OLIVEIRA DA SILVA, TERCIA RODRIGUES
ALVES, VIVALDO MOURA NETO, VERÔNICA MARIA MORANDI DA SILVA
B - 115
SEX HORMONES INFLUENCE ADAMTS PROTEASE LEVELS IN
OVARIAN TUMOR CELLS. MAÍRA DE ASSIS LIMA, VANESSA MORAIS FREITAS
B - 116
THE EXPRESSION OF STAT3 IN THE NUCLEUS IS ASSOCIATED WITH
PROLIFERATION IN GLIOBLASTOMA MULTIFORME. BRUNA ROZ RODRIGUES,
MARILENE HOHMUTH LOPES, ISABELA WERNECK DA CUNHA, VILMA REGINA
MARTINS
B - 117
NF-KB COORDINATES EPITHELIAL-MESENCHYMAL TRANSITION
PROPERTIES IN BREAST CANCER CELLS. BRUNO RICARDO BARRETO PIRES, ANDRE
LUIZ MENCALHA, AMANDA DE MORAES MAIA, ELIANA SAUL FURQUIM WERNECK
ABDELHAY
B - 118
MODULATION OF ENDOTHELIAL CELLS BY HUMAN TUMOR
MICROENVIRONMENT: A ROLE FOR SYNTHETIC ANALOGUES OF LIPOXINS.
ANDREZA MAIA VIEIRA, EDWARD HELAL NETO, CAMILA CASTRO FIGUEIREDO,
THEREZA CHRISTINA BARJA-FIDALGO, IOLANDA M. FIERRO, VERÔNICA MARIA
MORANDI DA SILVA
93
B - 119
MALIGNANT HODGKIN CELLS RELEASE CD30 ON MICROVESICLES
TO FACILITATE CROSSTALK WITH CD30L ON DISTANT IMMUNE CELLS OF THE
TUMOR MICROENVIRONMENT, IN VITRO. HINRICH P HANSEN, ELKE POGGE-VONSTRANDMANN, ADRIANA F PAES LEME, HANNA M ENGELS, VIJAYA L SIMHADRI,
MARIA DAMS, ROLF SCHUBERT, FABIO QUONDAMATTEO
B - 120
CELL PROLIFERATION EVALUATION OF THE CUTANEOUS
SQUAMOUS CELL CARCINOMA IN MICE AFTER PHOTODYNAMIC THERAPY. ANA
PAULA DA SILVA, FRANCISCO JAVIER HERNANDEZ BLAZQUEZ, DIVINOMAR
SEVERINO, MAURICIO DA SILVA BAPTISTA, BRUNO COGLIATI, MARIA LÚCIA
ZAIDAN DAGLI, ELISANGELA DOS ANJOS SILVA, CAMILA LIMA NEVES, JOSÉ
ROBERTO MACHADO CUNHA DA SILVA
B - 121
EVALUATION OF PRENEOPLASTIC LESIONS AND CELL
PROLIFERATION IN EXPERIMENTAL HEPATOCARCINOGENESIS DEVELOPED IN
CIRRHOTIC MICROENVIRONMENT. TANIA CRISTINA LIMA, CINTIA MARIA
MONTEIRO DE ARAUJO, VENANCIO AVANCINI FERREIRA ALVES, MARIA LUCIA
ZAIDAN DAGLI, BRUNO COGLIATI, FRANCISCO JAVIER HERNANDEZ BLAZQUEZ,
JOSE ROBERTO MACHADO CUNHA DA SILVA
B - 122
THE ROLE OF FMNL1 IN LEUKEMOGENESIS. PATRICIA MARIA
BERGAMO FAVARO, JOAO AGOSTINHO MACHADO NETO, MARIANA LAZARINI,
FABIOLA TRAINA, MATHEUS RODRIGUES LOPES, ELVIRA INFANTE, ANNE RIDLEY,
FERNANDO FERREIRA COSTA, SARA OLALLA-SAAD
B - 123
QUERCETIN: POSSIBLE EFFECT ANTI-MDR IN ERYTHROLEUKEMIA
HUMAN CELL LINES. MAIARA BERNARDES MARQUES, REGINA COIMBRA ROLA,
ANA PAULA DE SOUZA VOTTO
GONÇALVES, JULIANO DOMIRACI PACCEZ, LUIZ ZERBINI, SILVYA STUCHI MARIA
ENGLER, ANDRÉIA BUFFON, MÁRCIA ROSÂNGELA WINK
B - 136
ENTEROLOBIUM CONTORTISILIQUUM TRYPSIN INHIBITOR (ECTI), A
PLANT PROTEINASE INHIBITOR, DECREASES IN VITRO CELL ADHESION AND
INVASION BY INHIBITION OF SRC-FAK SIGNALING PATHWAYS. CLÁUDIA
ALESSANDRA ANDRADE DE PAULA, VIVIEN JANE COULSON-THOMAS, JOANA
GASPERAZZO FERREIRA, PALOMA KOREHISA MAZA, ERIKA SUZUKI, ADRIANA MITI
NAKAHATA, HELENA BONCIANI NADER, MISAKO UEMURA SAMPAIO, MARIA LUIZA
VILELA OLIVA
B - 137
EXPRESSION OF HPSE1 BY PROSTATE CELL LINES AND ITS
CONTRIBUTION TO TUMOR MICROENVIRONMENT. TAIZE MACHADO AUGUSTO,
ANA MILENA HERRERA, HERNANDES F CARVALHO
B - 138
XENOGRAPHIC TUMOR GROWTH USING LNCAP PROSTATE
CANCER CELL LINE IN IMMUNE COMPETENT MICE. ANA MILENA HERRERA
TORRES, TAIZE MACHADO AUGUSTO, HERNANDES F CARVALHO
B - 139
FUCAN B FROM BROWN SEAWEED SPATOGLOSSUM SCHRÖEDERI
AFFECTS VIABILITY OF DIFFERENT CANCER CELL LINEAGES AND INHIBITS
ANGIOGENESIS. LEONARDO THIAGO DUARTE BARRETO NOBRE, ARTHUR
ANTHUNES JÁCOME VIDAL, JAILMA ALMEIDA LIMA, RENAN PELLUZZI
CAVALHEIRO, EDUARDO HENRIQUE CUNHA DE FARIAS, EDGAR JULIAN PAREDES
GAMERO, HELENA BONCIANI NADER, HUGO ALEXANDRE DE OLIVEIRA ROCHA
B - 140
SURVIVIN AND XIAP EXPRESSION MODULATION IS ASSOCIATED
TO DOCETAXEL-INDUCED CELL DEATH IN BREAST CANCER CELLS. DEBORAH
DELBUE DA SILVA, GABRIELA NESTAL DE MORAES, RAQUEL CIUVALSCHI MAIA
B - 124
ANTIPROLIFERATIVE ACTIVITY OF LIPIDIC EXTRACTS OF MARINE
MICROALGAE ON A MELANOMA CELL LINE: PARTICIPATION OF OMEGA-3 PUFA?
RENATA OTTES VASCONCELOS, MICHELE MORAES DE SOUZA, ELIANA BADIALE
FURLONG, PAULO CESAR OLIVEIRA VERGNE DE ABREU, MILENE MEDEIROS DE
MORAES, JULIANA RAMOS GONZALEZ, ANA PAULA DE SOUZA VOTTO, GILMA
SANTOS TRINDADE
B - 141
ACTION OF HEAT SHOCK PROTEINS IN THERAPY PHOTODYNAMIC
CELLS IN PROSTATE CANCER. ERIANE ELLER DE SIQUEIRA, JULIANA FREIRES
MANGOLIN, ANDREZA CRISTINA DE SIQUEIRA SILVA, NEWTON SOARES DA SILVA,
CRISTINA PACHECO SOARES
B - 125
LAMININ-DERIVED PEPTIDE C16 INDUCES INVASION AND
INVADOPODIA FORMATION IN ORAL SQUAMOUS CELL CARCINOMA AND
FIBROSARCOMA CELLS. ADRIANE SOUSA DE SIQUEIRA, MONIQUE PEREIRA PINTO,
MÁRIO COSTA CRUZ, VANESSA MORAIS FREITAS, RUY GASTALDONI JAEGER
B - 142
GENOTOXICITY ASSESSMENT OF PHOTODYNAMIC THERAPY WITH
CHLORO-ALUMINUM
PHTHALOCYANINE
AND
CHLORO-ALUMINUM
PHTHALOCYANINE IN DIFFERENT CELL LINES. ANDREZA CRISTINA DE SIQUEIRA
SILVA, ERIANE ELLER DE SIQUEIRA, JULIANA FREIRES MANGOLIN, NEWTON
SOARES DA SILVA, ANTONIO CLÁUDIO TEDESCO, ANDREZA RIBEIRO SIMIONI,
CRISTINA PACHECO SOARES
B - 126
INHIBITION OF HEDGEHOG PATHWAY IN LEUKEMIC CELL LINEAGE
RESULTS IN CELL CYCLE ARREST, DECREASE IN PROLIFERATION AND CLONOGENIC
ABILITY WITHOUT INDUCED APOPTOSIS. JULIANA M XAVIER, SARA TEREZINHA
OLALLA SAAD
B -127
TUMOR METABOLITES MODULATE THE INTERACTION OF
ENDOTHELIAL PROGENITOR CELLS AND MATURE ENDOTHELIAL CELLS: ROLE OF
MATRIX METALLOPROTEASES AND AKT SIGNALING PATHWAY. FERNANDA
RODRIGUES LANZANA FERREIRA, VERÔNICA MORANDI, CAMILA CASTRO
FIGUEIREDO
B - 128
EFFECTS OF FLAVONOIDS ON GLIOBLASTOMA CELLS. JULIANA
MOREIRA SOARES, ANTONIO GOMES SOARES, VIVALDO MOURA NETO, LUCIANA
FERREIRA ROMÃO
B - 129
PARTIAL CHARACTERIZATION AND EVALUATION OF ANTITUMOR
POTENTIAL OF AN L-AMINO ACID OXIDASE OBTAINED OF BOTHROPS
JARARACUSSU. NATALIA CRISTINA SANTOS COSTA, MONISE VIANA ABRANCHES,
LORENA NACIF MARÇAL, GRACIELLE RODRIGUES PEREIRA, HELIOMAR CAZELLI DE
OLIVEIRA FILHO, RENATO NEVES FEIO, SÉRGIO OLIVEIRA DE PAULA, LEANDRO
LICURSI DE OLIVEIRA
B - 130
VINCRISTINE AND CHRYSOTILE INDUCE MULTIPOLAR MITOSIS IN
LUNG CANCER CELLS BY DIFFERENT MECHANISMS. BEATRIZ DE ARAUJO CORTEZ,
LUANA RIBEIRO RICARDI, GLAUCIA MARIA MACHADO SANTELLI
B - 131
INHIBITION OF THE V-TYPE H+-ATPASE AFFECTS THE APOPTOSIS,
MIGRATION AND INVASION CAPACITIES OF MELANOMA CELL LINES. GILDEÍDE
APARECIDA COSTA, BRUNNA XAVIER MARTINS, DANIELE SEIPEL DA SILVA, ANDREA
VETÖ ARNHOLDT, ANNA LVOVNA OKOROKOVA-FAÇANHA, ARNOLDO ROCHA
FAÇANHA.
B - 132
CHARACTERIZATION OF THE EXPRESSION OF NA+, K+-ATPASE
SUBUNITS IN HUMAN BREAST CANCER CELLS. MELINA ALMEIDA DIAS, MÁRCIA
ALVES MARQUES CAPELLA, ANÍBAL GIL LOPES
B - 133
EFFECT OF S-NITROSOGLUTATHIONE ON 5-FLUOROURACIL
INDUCED EXPERIMENTAL ORAL MUCOSITIS AND THE IMPACT OF ORAL
MUCOSITIS ON BACTERIAL FLORA OF HAMSTERS. MARIA ADRIANA SKEFF DE
PAULA MIRANDA, ANA PAULA VIEIRA COLOMBO, CARINA MACIEL DA SILVABOGHOSSIAN, CÍNTIA DE MELO BRAGA, MATHEUS MARTINS CAVALCANTE,
VIVALDO MOURA NETO, RENATA FERREIRA DE CARVALHO LEITÃO
B - 134
CELL
MIGRATION
IN
T-CELL
LYMPHOBLASTIC
LEUKEMIA/LYMPHOMA: THE ROLE OF THE SPHINGOSINE-1-PHOSFATE RECEPTOR
1. CAROLINA VALENÇA MESSIAS RACHID, JULIA PEREIRA LEMOS, WILSON SAVINO,
DANIELLA ARÊAS MENDES-DA-CRUZ
B - 135
THE HUMAN METASTATIC MELANOMA CELL LINE, SKMEL147,
PRESENTS A DIFFERENT NUCLEOTIDE DEGRADATION PROFILE IN COMPARISON
TO MELANOCYTES. CAROLINE GUERRA MARANGON, JÉSSICA MIETHICKI DA SILVA
B - 143
STUDY OF CANCER STEM CELLS IN INFLAMMATION ASSOCIATED
COLORECTAL CANCER USING THE AOM-DSS MODEL. DYANNA GALAXE DE
MATOS, CLAUDIO BERNARDAZZI, LUCAS LOBIANCO DE MATHEO, ANA CAROLINA
DUDENHOEFFER CARNEIRO, HEITOR SIFFERT PEREIRA DE SOUZA, ROSSANA COLLA
SOLETTI, HELENA LOBO BORGES
B - 144
QUANTITATIVE PROTEOME EXPRESSION ANALYSIS OF HUMAN
BREAST CANCER CELL LINES T47D AND MCF-7. DENISE DE ABREU PEREIRA,
VANESSA SANDIM SIQUEIRA, ANNELIESE FORTUNA DE AZEVEDO FREIRE DA
COSTA, ARACI DA ROCHA RONDON, ANA LÚCIA DE OLIVEIRA CARVALHO, MARIA
ISABEL DORIA ROSSI, DÁRIO ELUAN KALUME, RUSSOLINA BENEDETA ZINGALI
B - 145
EXTRACT PLANT FROM D.PICTA: A POTENTIAL ANTIPROLIFERATIVE
AGAINST TUMOR CELLS. CECÍLIO PURCINO DA SILVA SOUZA NETO, ANA CLARA
QUEIROZ
B - 146
ANTI-TUMORAL AND ANTI-ANGIOGENIC EFFECTS OF FUCSULF-I, A
SULFATED FUCAN FROM LYTECHINUS VARIEGATUS. VIVIANE WALLERSTEIN
MIGNONE DANTAS, ELIENE KOZLOWSKI, MAURO PAVÃO, PAULO MOURÃO,
CAMILA CASTRO FIGUEIREDO, VERÔNICA MORANDI
B - 147
EVALUATION OF THE CELL VIABILITY FROM FEMALE CANCER CELL
LINES AFTER TREATMENT WITH DIFFERENT FRACTIONS OF B. ARTICULATA.
GABRIEL FERNANDES SILVEIRA, SCHERON RATHKE GIUBEL, KETLEN DA SILVEIRA
MORAES, CRISTIANE BERNARDES DE OLIVEIRA, GRACE GOSMANN, ANDRÉIA
BUFFON, ALESSANDRA NEJAR BRUNO
B - 148
PATTERNS OF PROTEOGLYCANS EXPRESSION IN CACO-2 AND
HCT116 COLORECTAL CANCER CELLS INDUCED BY VIOLACEIN. GRACE RICHTER
MOYSÉS, CAROLINA MELONI VICENTE, LENY TOMA, HELENA BONCIANI NADER,
GISELLE ZENKER JUSTO
B - 149
THE ROLE OF CELLULAR REDOX POTENTIAL AND THE
EFFECTIVENESS OF CHEMOTHERAPY IN NON SMALL CELL LUNG CANCER.
VALESKA AGUIAR DE OLIVEIRA, LEONARDO LISBÔA DA MOTTA, FERNANDA
MARTINS LOPES, MARCO ANTÔNIO DE BASTIANI, FABIO KLAMT
B - 150
HIGH TUMORIGENIC CELLS IN HEAD AND NECK CANCER. ANA
LUÍSA HOMEM DE CARVALHO, LAURA DE CAMPOS HILDEBRAND, ISABEL DA SILVA
LAUXEN, CARLOS THADEU CERSKI, JACQUES EDUARDO NÖR, MANOEL SANT”ANA
FILHO
B - 151
IMMUNOLOCALIZATION
OF
TIMP-2
DURING
TUMOR
PROGRESSION AZOXYMETHANE INDUCED IN THE LARGE INTESTINE OF ADULT
RATS. JAIME RIBEIRO FREITAS, ELIAKIN ROBERTO DO CARMO, JESSICA DA SILVA,
KAMILA CAROLINE CAMARGO, LAÍS COSTA AYUB, PEDRO DUARTE NOVAES, CARLA
CRISTINE KANUNFRE, MARIA ALBERTINA DE MIRANDA SOARES, JOSÉ ROSA
GOMES
94
B - 152
INFLUENCE OF NUCLEOTIDE EXCISION REPAIR IN MITOXANTRONE
CITOTOXICITY. FRANCIELE FACCIO BUSATTO, JAQUELINE CESAR ROCHA, JENIFER
SAFFI
B - 153
DIFFERENTIAL EXPRESSION OF NTPDASES AND ECTO-5’NUCLEOTIDASE IN CERVICAL CARCINOMA CELLS. ALINE BECKENKAMP, DANIELLE
BERTODO SANTANA, CAROLINE GUERRA MARANGON, ALESSANDRA NEJAR
BRUNO, EMERSON ANDRÉ CASALI, LUCIANE NOAL CALIL, LUIZ FERNANDO ZERBINI,
JULIANO PACCEZ, GUIDO LENZ, MÁRCIA ROSÂNGELA WINK, ANDRÉIA BUFFON
B - 154
ABCB1 EFFECT ON ARSENIC TRIOXIDE RESISTANCE IN CHRONIC
MYELOID LEUKEMIA CELL LINES. RAPHAEL SILVEIRA VIDAL, NATHALIE HENRIQUES
SILVA CANEDO, VIVIAN MARY BARRAL DODD RUMJANEK, MARIA DA GLORIA DA
COSTA CARVALHO
B - 155
EVALUATION OF NMDA RECEPTOR EXPRESSION AND EFFECT OF
THE NMDAR ANTAGONISTS ON THE CELL VIABILITY OF CENTRAL NERVOUS
SYSTEM TUMORS. DÉBORA SCHOENFELD PRUSCH, CAROLINE BRUNETTO DE
FARIAS, GILBERTO SCHWARTSMANN, ANA LUCIA ABUJAMRA, RAFAEL ROESLER
B - 156
AUTOPHAGY ACTIVATION IN COLORECTAL CANCER CONTRIBUTE
TO THE TOLERANCE OF OXALIPLATIN UNDER ENERGY STRESS CONDITIONS.
DIANA LILIAN BORDIN, MICHELLE DE SOUZA LIMA LIMA, GUIDO LENZ, JOÃO
ANTONIO PEGAS HENRIQUES
B - 157
EFFECTS OF AN RGD-DISINTEGRIN IN BREAST CANCER. CARMEN
LUCIA SALLA PONTES, RADU O MINEA, STEVE SWENSON, FRANCIS MARKLAND JR,
HELOISA SOBREIRO SELISTRE DE ARAÚJO
B - 158
METASTATIC MELANOMA: NEW TARGETS FOR DIAGNOSIS AND
TREATMENT. RAUL FERRAZ ARRUDA, WILLIAM RODRIGUES FREITAS, MILTON
MASAHIKO KANASHIRO, NADIR FRANCISCA SANNT'ANNA, ARNOLDO ROCHA
FAÇANHA
B - 159
EXPRESSION AND FUNCTION OF THE CLOTTING INITIATOR
PROTEIN, TISSUE FACTOR, CORRELATE WITH CANCER STEM CELLS PHENOTYPE IN
HUMAN BREAST CANCER CELL LINES. ARACI MARIA DA ROCHA RONDON,
ANNELIESE FORTUNA DE AZEVEDO FREIRE DA COSTA, ANA PAULA DANTAS NUNES
DE BARROS, LUIZE GONÇALVES LIMA, ROBSON DE QUEIROZ MONTEIRO, MARIA
ISABEL DORIA ROSSI
B -160
CHEMICAL STUDIES AND EVALUATION OF BACCHARIS TRIMERA IN
CERVICAL CARCINOMA CELL LINE. OLIVEIRA CB, MACIEL ES, GIUBEL SR, MESQUITA
CB, COMUNELLO LN, SILVEIRA GF, BRUNO AN, BUFFON A, GOSMANN G
B - 161
STUDY OF REARRANGEMENTS BCR-ABL P190 AND P210 IN ADULT
ACUTE LYMPHOBLASTIC LEUKEMIA. RUI MILTON PATRÍCIO DA SILVA JÚNIOR,
JULIANA FERNANDA HOLANDA BEZERRA, AUDREY VIOLETA MARTINS DE
VASCONCELOS, TÂNIA MARIA ROCHA GUIMARÃES, WASHINGTON BATISTA NEVES,
FÁRIDA COELI DE BARROS CORREIA MELO, RAUL ANTÔNIO MORAIS MELO
B - 162
EPITHELIAL OVARIAN CANCER CELL LINE CLASSIFICATION MODEL
BASED ON MOLECULAR HETEROGENEITY AND CHEMOTHERAPY RESPONSE.
GUILHERME B FORTES, HAYNNA P KIMIE INADA, JOYCE L MORAES, CINTHYA
STERNBERG
B - 163
EVALUATION OF CELL PROLIFERATION IN CANINE MALIGNANT
MAMMARY TUMORS. CRISTINA MENDES PLIEGO, FRANCIELE BASSO FERNANDES
SILVA, JULIANA DA SILVA LEITE, MARCELA FREIRE VALLIM DE MELLO, GABRIELLA
CARVALHO MATTOS FERREIRA, MARIA DE LOURDES GONÇALVES FERREIRA, ANA
MARIA REIS FERREIRA
B - 164
EVALUATION OF PROGRAMMED CELL DEATH IN MAMMARY
CARCINOMAS OF FEMALE DOGS. FRANCIELE BASSO FERNANDES SILVA, CRISTINA
MENDES PLIEGO, JULIANA DA SILVA LEITE, MARCELA FREIRE VALLIM DE MELLO,
BETTINA CAMPOS BRITO CUNHA, MARIA DE LOURDES GONÇALVES FERREIRA, ANA
MARIA REIS FERREIRA
B - 165
MECHANISMS OF ACETYLEUGENOL NANOCAPSULES ON TOXICITY
OF MELANOMA CELLS. CARINE CRISTIANE DREWES, LUANA ALMEIDA FIEL,
ADRIANA R. POHLMANN, SÍLVIA S. GUTERRES, SANDRA HELENA P. FARSKY
B - 166
P53-DEFICIENT MELANOMA CELLS ARE MORE SENSITIVE TO THE
CYTOTOXIC EFFECTS OF UVB IRRADIATION: INVOLVEMENT OF DNA REPAIR
ACTIVATION PATHWAYS AND PEROXIDE PRODUCTION. GUILHERME FRANCISCO,
TAYNAH IBRAHIM PICOLO DAVID, BRYAN ERIC STRAUSS, ROGER CHAMMAS
B - 167
LAMININ-DERIVED PEPTIDES AG73 AND C16 REGULATE
MIGRATION AND INVASION OF A HUMAN PROSTATIC CARCINOMA CELL LINE.
ADRIANE SOUSA DE SIQUEIRA, TAÍZE M. AUGUSTO, HERNANDES F. CARVALHO,
RUY GASTALDONI JAEGER
B - 168
INFLUENCE
OF
THE
ADAMTS-1
BREAST
TUMOR
MICROENVIRONMENT. THAIOMARA ALVES SILVA, ADRIANE S. SIQUEIRA, MÁRIO
C. CRUZ, RUY G. JAEGER, VANESSA M. FREITAS
B - 169
VASCULAR
ENDOTHELIAL
GROWTH
FACTOR
936C/T
POLYMORPHISM IN BRAZILIAN PATIENTS WITH ORAL SQUAMOUS CELL
CARCINOMA (OSCC). JÚLIA SALLABERRY PINTO, FERNANDA NEDEL, TIAGO VEIRAS
COLLARES, FABIANA KÖMMLING SEIXAS, SANDRA BEATRIZ CHAVES TARQUINIO
B - 170
ECTO-ADENOSINE DEAMINASE CHARACTERIZATION ACTIVITY IN
HUMAN CERVICAL CARCINOMA CELLS. DANIELLE BERTODO SANTANA, ALINE
BECKENKAMP, JÉSSICA NASCIMENTO, ALESSANDRA NEJAR BRUNO, ANDRÉIA
BUFFON
B - 171
ATL-1, A SYNTHETIC ANALOG OF 15-EPI-LIPOXIN A4, MODULATES
KEY FUNCTION OF TUMOR-ASSOCIATED MACROPHAGE: A POTENTIAL ANTITUMORAL TOOL. NATÁLIA MESQUITA DE BRITO, RAFAEL LOUREIRO SIMÕES,
IOLANDA MARGHERITA FIERRO, THEREZA CHRISTINA BARJA FIDALGO
B - 172
ENHANCED ANTITUMOR EFFECTS OF 3,4-DIHYDROPYRIMIDINE
DERIVATIVES (DHPMS) ON HUMAN BREAST CANCER CELLS. BRUNA CÂNDIDO
GUIDO, LUCIANA M. RAMOS, CATHARINE C. NÓBREGA, BRENNO A. D. NETO, JOSÉ
R. CORRÊA
B - 173
CELLULAR RESPONSE ANALYSIS IN COLORECTAL CANCER AND
LUNG CANCER CELLS EXPOSED TO TREATMENT WITH PLATINUM AGENTS IN LOW
GLUCOSE CONDITIONS. MICHELLE DE SOUZA LIMA, DIANA LILIAN BORDIN, GUIDO
LENZ, JOÃO ANTÔNIO PEGAS HENRIQUES
B - 174
ANXA1 SUBCELLULAR LOCALIZATION AND CELL PROLIFERATION.
LARA VECCHI, LARISSA PRADO MAIA, BRUNA FRANÇA MATIAS, LUIZ RICARDO
GOULART FILHO
B - 175
IMMUNOHISTOCHEMICAL STUDY OF FIBROBLAST GROWTH
FACTOR-2 (FGF-2) IN MALIGNANT AND BENIGN SALIVARY GLAND TUMORS.
DÉBORA OLIVEIRA SANTOS, TAMIRIS SABRINA RODRIGUES, SERGIO VITORINO
CARDOSO, KAREN RENATA NAKAMURA HIRAKI
B - 176
SECRETOME: A RESERVOIR OF BIOACTIVE MOLECULES. REBECA
KAWAHARA, ANNELIZE Z.B. ARAGÃO, RAFAEL R. CANEVAROLO, GABRIELA V.
MEIRELLES, FERNANDO M. SIMABUCO, RONEI J. POPPI, ISADORA L. FLORES,
RICARDO D. COLETTA, NICHOLAS E. SHERMAN, ADRIANA F. PAES LEME
B - 177
ANALYSIS OF THE EFFECT OF CYCLOOXYGENASE ON THE
EXPRESSION AND ACTIVITY OF MULTIPLE DRUG RESISTANCE PROTEINS (MDRP)
IN HUMAN GLIOMA. FERNANDA DE OLIVEIRA SERACHI, ALISON COLQUHOUN
B - 178
ANALYSIS OF THE EFFECT OF PROSTAGLANDIN E2 AND IBUPROFEN
ON CELL NUMBER AND EXTRACELLULAR MATRIX SYNTHESIS IN U87MG AND
U251MG HUMAN GLIOMA CELL LINES. FABIO FEITOZA, ALISON COLQUHOUN
B - 179
FUNCTIONAL CHARACTERIZATION OF THE LEUKEMIC STEM CELL IN
THE ACUTE PROMIELOCYTIC LEUKEMIA. LUCIANA MARIA FONTANARI KRAUSE,
ALEXANDRE KRAUSE, HELDER HENRIQUE PAIVA, EDUARDO MAGALHÃES REGO
B - 180
EVALUATION OF THE CYTOTOXIC ACTIVITY OF NEW
NITROFURANTOIN DERIVATIVES. JEYCE KELLE FERREIRA DE ANDRADE, MARIA DO
DESTERRO RODRIGUES, LARISSA CARDOSO CORRÊA DE ARAÚJO, PAULO BRUNO
NORBERTO DA SILVA, DALCI JOSÉ BRONDANI, MANOEL ADRIÃO GOMES FILHO,
GARDENIA CARMEN GADELHA MILITÃO, TERESINHA GOLÇALVES DA SILVA
B - 181
THE ROLE OF CD73 IN THE PROGNOSIS OF HUMAN
MEDULOBLASTOMA CELL LINES. CAPPELLARI, A.R., DIETRICH, F., ROCKEMBACH,
L., CLARIMUNDO, V., BRAGANHOL, E., ABUJAMRA , A.L., ROESLER, R., HENNING,
U., BATTATASTINI, A.M.O.
B - 182
ACTION OF PHOTODYNAMIC THERAPY IN THE EXPRESSION OF
ADHESION PROTEINS. CAROLINA GENÚNCIO DA CUNHA MENEZES COSTA, KAREN
CRISTIANE MARTINEZ DE MORAES, NEWTON SOARES DA SILVA, CRISTINA
PACHECO SOARES
B - 183
ANALISYS GENETIC AND MICROSCOPIC OF FIBROPAPILLOMATOSIS
IN CHELONIA MYDAS. SAMARA MAFTOUM COSTA, CAROLINA GENÚNCIO DA
CUNHA MENEZES COSTA, CRISTINA PACHECO SOARES
B - 184
ROLE OF DERMCIDIN IN TOMORIGENESIS OF MELANOMAS.
BEATRIZ SANGIULIANO, MARCELA PEREZ, ALINE CADURIN, ANDREW AGUIAR, JOSÉ
BELIZÁRIO
B - 185
MODULATION OF ENDOTHELIAL CELL ADHESION AND
TUBULOGENESIS IN A MODEL OF GLIOMA CELLS SILENCED FOR TENASCIN-C (TNC) EXPRESSION. LAILA RIBEIRO FERNANDES, ADELAIDE CRISTINA DA SILVA
MONTEIRO, KELLI CRISTINA MICOCCI, ALINE OLIVEIRA DA SILVA, TERCIA
RODRIGUES ALVES, HELOISA SOBREIRO SELISTRE DE ARAUJO, VIVALDO MOURA
NETO, VERÔNICA MARIA MORANDI DA SILVA
B - 186
ALKALINE PHOSPHATASE EXPRESSION IN INTESTINAL EPITHELIUM
OF RATS INJECTED WITH AZOXYMETHANE. LAÍS COSTA AYUB, JAIME RIBEIRO
FREITAS, KAMILA CAROLINE CAMARGO, PEDRO DUARTE NOVAES, MARIA
ALBERTINA DE MIRANDA SOARES, CRISTINA LÚCIA SANT”ANA COSTA AYUB, NÁDIA
FAYEZ OMAR, JOSÉ ROSA GOMES
B - 187
CYTOTOXIC EFFECTS ON ORAL SQUAMOUS CELL CARCINOMA
(OSCC) INDUCED BY EXTRACTS FROM THE ARISTOLOCHIA GENUS. NAYARA
SANTOS DE MATOS, ANDREA BARRETTO MOTOYAMA
B - 188
EVALUATION OF THE ROLE OF CISPLATIN AS SENSITIZER TO TRAIL
IN BREAST CANCER CELL LINES. VIVIANE ALVES MONTEIRO, CARLOS GIL FERREIRA,
CINTHYA STERNBERG
B - 189
INVESTIGATION OF ANTITUMOR ACTIVITY OF 1,3-THIAZIN-2,4DIONES AGAINST MELANOMA CELLS. LAURA SARTORI ASSUNÇÃO, MISAEL
95
FERREIRA, FABIOLA FILIPPIN MONTEIRO, MARCUS MANDOLESI SÁ, TANIA BEATRIZ
CRECZYNSKI-PASA
B - 190
VIOLACEIN INDUCES SPECIFIC ALTERATIONS IN PROTEOGLYCANS
PROFILE IN CHRONIC MYELOID LEUKEMIAS. MARCELLY VALLE PALLADINO, MARIA
APARECIDA DA SILVA PINHAL, JULIANA LUPORINI DREYFUSS, ELSA YOKO
KOBAYASHI, HELENA BONCIANI NADER, GISELLE ZENKER JUSTO
B - 191
DUAL ROLE OF TGFBETA DURING COLORECTAL CANCER
PROGRESSION. PEDRO HENRIQUE SCHUMANN LIMA, MARCELO NEVES TANAKA,
BRUNO K. ROBBS, JOÃO PAULO DE BIASO VIOLA, JOSÉ ANDRÉS MORGADO-DÍAZ
B -192
INHIBITION OF MELANOMA CELL MIGRATION BY CINNAMIC ACID:
AN IN VITRO STUDY ANALI DEL MILAGROS BERNABE GARNIQUE, GLÁUCIA MARIA
MACHADO-SANTELLI, EVANDRO LUÍS DE OLIVEIRA NIERO
B - 193
SPARC/OSTEONECTIN EXPRESSION MEDIATES CHEMOSENSITIVITY
TO DOCETAXEL IN MCF-7 BREAST CANCER CELLS. ÚRSULA URIAS, MARIA
APARECIDA NAGAI
B - 194
CHARACTERIZATION OF TUMOR STEM CELLS IN HUMAN
GLIOBLASTOMA. ROSENILDE CARVALHO DE HOLANDA AFONSO, SUZANA ASSAD
KAHN, DENISE DA SILVEIRA LOBO, DIANA MATIAS, JANE CRISTINA DE OLIVEIRA
FARIA, LUCIANA FERREIRA ROMÃO, CELINA GARCIA DA FONSECA, GRASIELLA
MARIA VENTURA MATIOSZEK, ALINE MARIE FERNANDES, STEVENS REHEN, JORGE
MARCONDES DE SOUZA, VIVALDO MOURA NETO
B - 195
ASSOCIATION OF THYMIDYLATE SYNTHASE AND METHYLENETETRAHYDROFOLATE REDUCTASE POLYMORPHISMS IN PATIENTS WITH
ASTROCYTIC TUMORS IN A POPULATION OF NORTHERN BRAZIL. MARIANA DINIZ
ARAÚJO, WALLAX AUGUSTO SILVA FERREIRA, SYMARA RODRIGUES-ANTUNES,
MARICELE BAIA DOS SANTOS, JOSÉ REGINALDO NASCIMENTO BRITO, DOUGLAS
VASCONCELOS, NILSON PRAIA ANSELMO, ROMMEL MARIO RODRIGUEZ
BURBANO, MARIA LÚCIA HARADA, BÁRBARA DO NASCIMENTO BORGES
B - 196
EXPRESSION OF NEUROMEDIN B AND ITS AGONIST IN HUMAN
MEDULLOBLASTOMA. MARIANE DA CUNHA JAEGER, CAROLINA NOR, CAROLINE
BRUNETTO DE FARIAS, ANA LUCIA ABUJAMRA, GILBERTO SCHWARTSMANN,
ALGEMIR LUNARDI BRUNETTO, RAFAEL ROESLER
B - 197
COULD NARINGIN PROTECT THE LIVER OF WISTAR RATS
INOCULATED WITH WALKER 256 CARCINOSARCOMA? MARIA APARECIDA DA
SILVA DIAMANTE, CAMILA DE ANDRADE CAMARGO, FABRICIA DE SOUZA PREDES,
HIROSHI AOYAMA, MARY ANNE HEIDI DOLDER
B - 198
THE ROLE OF MTOR IN THE CISPLATIN RESISTANT PHENOTYPE IN
OVARIAN CANCER LINEAGE. TACIANE LADISLAU, DÉBORA SILVA, KLESIA PIROLA
MADEIRA, RENATA DALMASCHIO DALTOÉ, ALICE LASCHUK HERLINGER, IAN
VICTOR SILVA, LETICIA BATISTA AZEVEDO RANGEL
B - 199
CLINICOPATHOLOGICAL SIGNIFICANCE OF ADAMTS-1 AND
VERSICAN IN OVARY CANCER. JOSÉ ANTONIO ORELLANA TURRI, SUELI
NONOGAKI, MARCILEI BUIM, JOEMA FELIPE LIMA, CYNTHIA APARECIDA BUENO DE
TOLEDO OSÓRIO, FERNADO AUGUSTO SOARES, VANESSA MORAIS FREITAS
B - 200
MUTATIONAL STATUS OF THE TP53 GENE IN CANINE MAMMARY
TUMORS. THAMIRYS ALINE SILVA FARO, WALLAX AUGUSTO SILVA FERREIRA,
SUELLEN DA GAMA BARBOSA MONGER, LUCIEN ROBERTA VALENTE MIRANDA DE
AGUIRRA, WASHINGTON LUIZ ASSUNÇÃO PEREIRA, MARIA LÚCIA HARADA,
BÁRBARA DO NASCIMENTO BORGES
B - 201
IMPACT OF TUMOR-DERIVED EXTRACELLULAR MATRIX ON
ENDOTHELIAL CELL FUNCTIONS AND ITS ASSOCIATION WITH TUMORASSOCIATED ANGIOGENESIS. RENATA MACHADO BRANDÃO COSTA, EDWARD
HELAL NETO, ROBERTA FERREIRA GOMES SALDANHA DA GAMA, THEREZA
CHRISTINA BARJA-FIDALGO, VERÔNICA MARIA MORANDI DA SILVA
B - 202
ANTIPROLIFERATIVE
ACTIVITY
OF
NOVEL
3TRIFLUOR(OXO)PYRIMIDO[1,2-A]BENZIMIDAZOLES COMPOUNDS. CASSIANA
MACAGNAN VIAU, NATÁLIA LEGUISAMO, DÉBORA CORREA ESPIÑA, SIMONE
SCHNEIDER AMARAL, JENIFER SAFFI
B - 203
IN VITRO ANTIPROLIFERATIVE ACTIVITY OF (3Β,6Β,16ΒTRIHYDROXY-LUP-20(29)-ENE) TRITERPENE AGAINST BREAST CANCER CELLS.
CASSIANA MACAGNAN VIAU, NATÁLIA LEGUISAMO, DÉBORA CORREA ESPIÑA,
JENIFER SAFFI
B - 204
PARP INHIBITION EXERTS SYNERGISTIC EFFECT ON THE
CARDIOTOXICITY OF TOPOISOMERASE II INHIBITORS. ROBERTO MARQUES
DAMIANI, MARIANA LUZZATTO, BRUNA CASTILHOS, DINARA JAQUELINE MOURA,
JOÃO ANTONIO PÊGAS HENRIQUES, JENIFER SAFFI
B - 205
GENOTOXIC ACTIVITY OF EXTRACTS OF MARINE ALGAE FROM THE
COAST OF ALAGOAS – BRAZIL. BRUNNO HENRIQUE DA SILVA, ISA RAFAELLA
ROCHA BRITO, ÉLICA AMARA CECÍLIA GUEDES, ANTÔNIO EUZÉBIO GOULART
SANT’ANA, RENATO S. RODARTE
B - 206
CYTOTOXIC EFFECT OF THE ISATIN DERIVATES ON LEUKEMIC CELL
LINES. GLAUCIA VERÍSSIMO FAHEINA MARTINS, CAIO CÉSAR BARBOSA BOMFIM,
BRUNA BRAGA DANTAS, CLAUDIO GABRIEL L. JÚNIOR, MÁRIO L.A.A.
VASCONCELOS, DEMETRIUS A.M. ARAÚJO
B -207
ANALYSIS OF THE LEPTIN SIGNALING PATHWAY COMPONENTS OF
THYROID PAPILLARY CARCINOMA OF CHILDREN AND ADOLESCENTS BY
IMMUNOSTAINING. ARIO LUCIO CORDEIRO ARAUJO JUNIOR, VIVIANE YOUNESRAPOZO, NAYARA PEIXOTO-SILVA, ELAINE DE OLIVEIRA, PATRÍCIA CRISTINA
LISBOA, ROSSANA CORBO, MARCELLI GATTO, ALBANITA VIANA DE OLIVEIRA,
EGBERTO GASPAR DE MOURA
B - 208
APOPTOSIS INDUCTION BY A NEW DERIVATIVE OF
PODOPHYLLOTOXIN IN HL-60 CELLS. GLAUCIA VERÍSSIMO FAHEINA MARTINS,
ALETHÉIA LACERDA DA SILVEIRA, BRUNA BRAGA DANTAS, DEMETRIUS ANTONIO
MACHADO DE ARAÚJO
B -209
A NEW FAB INHIBITS CELL PROLIFERATION IN MCF7 BREAST
CARCINOMA CELLS. THAISE GONÇALVES ARAÚJO, CLÁUDIA MENDONÇA
RODRIGUES, BRUNA FRANÇA MATIAS, YARA C.PAIVA MAIA, ANGELA A.S. SENA,
CAROLINA FERNANDES REIS, CARLOS UEIRA VIEIRA, LUIZ RICARDO GOULART
B - 210
INDUCTION OF APOPTOSIS IN HUMAN LUNG ALVEOLAR
CARCINOMA EPITHELIAL CELLS (A549) BY THE METALLIC COMPLEX CISTETRAAMMINE(OXALATO)RUTHENIUM(III) DITHIONATE. ELISÂNGELA DE PAULA
SILVEIRA-LACERDA, FLÁVIA DE CASTRO PEREIRA, ALINY PEREIRA DE LIMA,
WANESSA CARVALHO PIRES, CESAR AUGUSTO SAM TIAGO VILANOVA-COSTA
B - 211
BREAST CANCER STEM CELL-LIKE PHENOTYPE OF A
SUBPOPULATION DERIVED FROM A LUMINAL CELL LINE. ANNELIESE FORTUNA DE
AZEVEDO FREIRE DA COSTA, ANA PAULA DANTAS NUNES DE BARROS, CAMILA
MARIA LONGO MACHADO, ARACI MARIA DA ROCHA RONDON, ANDREA
CORDOVIL PIRES, HÉLIO DOS SANTOS DUTRA, RADOVAN BOROJEVIC, ELIENE
OLIVEIRA KOZLOWSKI, MAURO SÉRGIO GONÇALVES PAVÃO, ROGER CHAMMAS,
MARIA ISABEL DORIA ROSSI
B - 212
UNDERSTANDING THE ROLE OF GENETIC INSTABILITY IN BASAL
CELL CARCINOGENESIS THROUGH ANALYSIS OF POLYMORPHIC REPETITIVE DNA
SEQUENCES. JULIANA S. CAPITANIO, MARCOS A. R. MARTINEZ, GUILHERME
FRANCISCO, CYRO FESTA-NETO, ITAMAR R. G. RUIZ
B - 213
IN VITRO ANTITUMOR ACTIVITY OF TRETINOIN-LOADED LIPIDCORE NANOCAPSULES ON HUMAN LUNG ADENOCARCINOMA EPITHELIAL CELL
LINE (A549). EDUARDA SCHULTZE, VIRGINIA YURGEL, KARINE RECH BEGNINI,
ALINE FERREIRA OURIQUE, RUY CARLOS RUVER BECK, STANISÇUAKI GUTERRES,
ADRIANA RAFFIN POHLMANN, FABIANA SEIXAS, TIAGO COLLARES
B - 214
MODULATION OF MELANIN SYNTHESIS BY PLATINUM COMPLEXES
(II) WITH HYDANTOIN DERIVATIVE AS A NOVEL ROUTE FOR CYTOTOXICITY IN
MELANOMA CELLS. FERNANDA BRANCO FILIPPIN, SUELY LINS GARDINO, MARIA
DO CARMO ALVES DE LIMA, IVAN DA ROCHA PITTA, SILVYA STUCHI MARIAENGLER
B - 215
B16F10 MELANOMA CELLS GROWN ON COLLAGEN MATRIX
EXHIBITED BEHAVIOR SIMILAR TO IN VIVO TUMOR. PAULA MEDEIROS SABINO,
BRUNO PIVA, BRUNO LOURENÇO DIAZ
B - 216
STRUCTURAL AND ULTRASTRUCTURAL DESCRIPTION OF THE
METAPLASIC AND NEOPLASIC PROCESSES IN RAT PROSTATE EPITHELIAL CELLS
AFTER SEX STEROIDS-INDUCED CARCINOGENESIS. JAQUELINE DE CARVALHO
RINALDI, HELOISA BORTOLIN BRUNO, LIVIA MARIA LACORTE, FLAVIA KARINA
DELELLA, LUIS ANTONIO JUSTULIN JUNIOR, SERGIO LUIS FELISBINO
B - 217
FREQUENCY OF HPV INFECTION IN HEAD AND NECK SQUAMOUS
CELL CARCINOMA AND ITS INFLUENCE IN CELL CYCLE RELATED PROTEINS TOP2A
AND MCM2. ANA CAROLINA LAUS, NAIARA CORRÊA NOGUEIRA DE SOUZA,
ADHEMAR LONGATTO FILHO, CRISTOVAM SCAPULATEMPO NETO, ANDRÉ LOPES
CARVALHO
B - 218
KNOCKDOWN OF XIAP COOPERATES WITH THE OVEREXPRESSION
OF P53 IN REDUCING CELL PROLIFERATION AND ENHANCING CELL DEATH IN
GLIOMAS. ANDREW OLIVEIRA SILVA, MICHELE HÜTTEN, PATRÍCIA LUCIANA DA
COSTA LOPEZ, GUIDO LENZ
B - 219
THE ROLE OF CELLULAR ADHESION STATE IN REGULATING
NUCLEAR AKT/PKB LOCALIZATION IN HUMAN MELANOMA CELL LINES
HARBORING DISTINCT ONCOGENC MUTATIONS. SARAH FRANCO FIGUEIRA,
RENATA PASCON, MARCELO AFONSO VALLIM, JOEL MACHADO JR.
B - 220
MICROARRAY ANALYSIS OF DIFFERENTIALLY EXPRESSED GENES IN
ADENOID CYSTIC CARCINOMA CELLS (CAC2) TREATED WITH LAMININ-DERIVED
PEPTIDES C16 OR AG73. MICAEL DE PAIVA OLIVEIRA, EMERSON S. SANTOS,
VANESSA M. FREITAS, BASILIO SMUCZEK, RUY G. JAEGER
B - 221
THE FLAVONOID ISOQUERCITRIN MODULATE PATHWAY WNT/ΒCATENIN THROUGH SPHINGOSINE KINASE IN HUMAN GLIOBLASTOMA CELLS IN
VITRO. FERNANDA MIRANDA, DÉBORA MALTA CERQUEIRA, RAFAEL LINDOSO,
MARCELO EINICKER-LAMAS, VIVALDO MOURA NETO, JOSÉ GARCIA ABREU
B - 222
PRPC AND HOP EXPRESSION AND SECRETION IN COLON AND
RECTUM TUMORS ARE ASSOCIATED WITH INVASION. TONIELLI CRISTINA SOUSA
DE LACERDA, MARCOS VINICIUS SALLES DIAS, CLEITON FAGUNDES MACHADO,
BRUNO COSTA SILVA, VILMA REGINA MARTINS
B - 223
EVALUATION OF THE CYTOTOXIC ACTIVITY OF NEW 4THIAZOLIDINONE. MARIA DO DESTERRO RODRIGUES, SANDRINE MARIA ARRUDA
DE LIMA, JEYCE KELLE FERREIRA DE ANDRADE, LARISSA CARDOSO CORRÊA DE
ARAÚJO, ERALDO ANTUNES GUIMARÃES NETO, JOSÉ GILDO DE LIMA, ALEXANDRE
96
JOSÉ DA SILVA GÓES, TERESINHA GONÇALVESDA SILVA, GARDENIA CARMEN
GADELHA MILITAO, SILENE CARNEIRO DO NASCIMENTO
AMARO DE MOURA, LUÍS HENRIQUE TOSHIHIRO SAKAMOTO, ANDREA BARRETTO
MOTOYAMA, FÁBIO PITTELLA SILVA
B - 224
MODULATION OF AUTOPHAGY PATHWAY GENE EXPRESSION
AFTER CROTAMINE TREATMENT OF TUMOR CELL LINE. MÁRCIA NEIVA, CAMILA
M YONAMINE, MARCELA B NERING, EDUARDO B OLIVEIRA, DANIELE Y SUNAGA,
MIRIAN A F HAYASHI
B - 241
EFFECT OF KIAA0090 KNOCKDOWN IN SOME ASPECTS OF
MELANOMA DEVELOPMENT, MAINTENANCE AND PROGRESSION. RODRIGO
RIBEIRO DA SILVA, CARLOS ANTONIO COUTO LIMA, ROBERTO AUGUSTO SILVA
MOLINA, NOEMI YASUKO OTSUKA, CIBELE CARDOSO, CRISTIANO GONÇALVES
PEREIRA, ENILZA MARIA ESPREAFICO
B - 225
AUXOTROPHIC RECOMBINANT BCG OVEREXPRESSING AG85B AS
AN ALTERNATIVE THERAPY FOR SUPERFICIAL BLADDER CANCER. KARINE RECH
BEGNINI, CAROLINE RIZZI, VINICIUS FARIAS CAMPOS, EDUARDA SCHULTZE,
VIRGINIA CAMPELLO YURGEL, TIAGO COLLARES, ODIR DELLAGOSTIN, FABIANA
KOMMLING SEIXAS
B - 242
EXPRESSION PROFILE OF SUPPRESSOR OF VARIEGATION (SUV)
GENE FAMILY IN BREAST CANCER CELL LINES. BRENNO VINÍCIUS MARTINS
HENRIQUE, CAROLINA AMARO DE MOURA, ANDREA BARRETO MOTOYAMA,
ROSÂNGELA VIEIRA DE ANDRADE, FÁBIO PITTELLA SILVA
B - 226
RUTHENIUM COMPLEX COORDENATED WITH LAPACHOL IS
CYTOTOXIC FOR DIFFERENT TUMOR CELL LINES AND INHIBITS TUMOR CELL
ADHESION. JULIANA UEMA RIBEIRO, MARÍLIA IMACULADA FRAZÃO BARBOSA,
MÁRCIA REGINA COMINETTI, ALZIR AZEVEDO BATISTA
B -2 43
KIAA0090, A NEW HUMAN GENE IS INVERSELY CORRELATED WITH
HER2 EXPRESSION AND ASSOCIATED WITH BREAST CANCER PROGRESSION.
ROBERTO AUGUSTO SILVA MOLINA, DANIEL TIEZZI, CIBELE CARDOSO, RODRIGO
RIBEIRO DA SILVA, NOEMI Y. OTSUKA, ENILZA MARIA ESPREAFICO
B - 227
EVALUATION OF GENOTOXIC EFFECTS IN LYMPHOCYTES OF MICE
FROM LEAF EXTRACTS ZIZIPHUS JOAZEIRO MARTIUS (RHAMNACEAE). ISA
RAFAELLA ROCHA BRITO, BRUNNO HENRIQUE DA SILVA, CLÁUDIA CAVALCANTE
DE MATOS RODARTE, ANTÔNIO EUZÉBIO GOULART SANT’ANA, RENATO S.
RODARTE
B - 244
CROSSTALK BETWEEN C6 GLIOMA CELLS AND MESENCHYMAL
STEM CELLS THROUGH SOLUBLE FACTORS AFFECTS THE PURINERGIC SYSTEM.
PAULA ANDREGHETTO BRACCO, SILVIA MULLER MOURA, GIOVANA RAVIZZONI
ONZI, LUANA DIMER HAINZENREDER, ADRIANO MARTIMBIANCO DE ASSIS, PEDRO
ROOSEVELT TORRES ROMÃO, MÁRCIA ROSÂNGELA WINK
B - 228
CONSTRUCTION OF A RECOMBINANT TAT-HA FUSOGENIC
MYOSIN-VA FRAGMENT COVERING THE BINDING MOTIF OF DLC2: EVALUATION
OF CELL PENETRATING AND PRO-APOPTOTIC PROPERTIES. ENILZA MARIA
ESPREAFICO, CLEIDSON DE PÁDUA ALVES, ENILZA MARIA ESPREAFICO
B - 245
THE NOVEL CYTOKINE PANDER/FAM3B AFFECTS CELL GROWTH
AND INHIBITS APOPTOSIS IN MDA-MB-231 BREAST TUMOR CELLS. LIBNAH LEAL,
IZABELA CALDEIRA, HUMBERTO MIGUEL GARAY MALPARTIDA
B - 229
EVALUATION OF CITOTOXIC ACTIVITY OF RHIZOPHORA MANGLE
ON HELA CELLS. MARLLON ALEX NASCIMENTO SANTANA, ELIANE ALVES
BANDEIRA DE CARVALHO, ERWELLY BARROS DE OLIVEIRA, KRÍSIA EMANUELLE
FERREIRA DA SILVA, PAULO HENRIQUE CAVALCANTI DE ARAÚJO, ELIETE
CAVALCANTI DA SILVA, ANTÔNIO FERNANDO MORAIS DE OLIVEIRA, JEYMESSON
RAPHAEL CARDOSO VIEIRA
B - 230
THE INFLUENCE OF A SELECTIVE INHIBITOR OF THE TYROSINE
PROTEIN KINASE ACTIVITY OF THE TRK FAMILY ON THE VIABILITY OF SH-SY5Y
HUMAN NEUROBLASTOMA CELLS. BÁRBARA KUNZLER SOUZA, CAROLINE
BRUNETTO DE FARIAS, GILBERTO SCHWARTSMANN, ALGEMIR LUNARDI
BRUNETTO, ANA LUCIA ABUJAMRA, RAFAEL ROESLER
B - 231
EFFECTS OF A GASTRIN-RELEASING PEPTIDE RECEPTOR
ANTAGONIST ON THE VIABILITY OF SH-SY5Y HUMAN NEUROBLASTOMA CELLS.
BÁRBARA KUNZLER SOUZA, CAROLINE BRUNETTO DE FARIAS, GILBERTO
SCHWARTSMANN, ALGEMIR LUNARDI BRUNETTO, ANA LUCIA ABUJAMRA, RAFAEL
ROESLER
B - 246
PROFILING OF DIFFERENTIALLY EXPRESSED APOPTOSIS-RELATED
GENES IN T47D BREAST CANCER CELLS TREATED WITH ANGIOTENSIN-(1-7).
CHERYL ALECRIM SANTOS, SILVANA APARECIDA ALVES CORREA DE NORONHA,
SAMUEL RIBEIRO DE NORONHA, SUMA IMURA SHIMUTA, CLOVIS RYUICHI NAKAIE,
ISMAEL DALE COTRIM GUERREIRO DA SILVA
B - 247
FUNCTIONAL CHARACTERIZATION OF A NOVEL GENE ASSOCIATED
WITH MELANOMA PROGRESSION AND BRAF V600E. CRISTIANO G PEREIRA,
RODRIGO R SILVA, CIBELE CARDOSO, ENILZA MARIA ESPREAFICO
B - 248
INVOLVEMENT OF MYOSIN-VA IN FOCAL ADHESION FORMATION
AND SURVIVAL UNDER SUBSTRATE DETACHMENT CONDITIONS. ANELISA
RAMÃO, CARMEN LUCIA SALLA PONTES, CLEIDSON PADUA ALVES, ENILZA MARIA
ESPREAFICO
B - 249
CHARACTERIZATION OF NEW MELANOMA-RESTRICTED GENES
ASSOCIATED WITH MAPK PATHWAY. CIBELE CARDOSO, CRISTIANO GONÇALVES
PEREIRA, RODRIGO RIBEIRO DA SILVA, ROBERTO AUGUSTO SILVA MOLINA,
GUILHERME AUGUSTO SILVA DOS SANTOS, EDUARDO MAGALHÃES REGO, ENILZA
MARIA ESPREAFICO
B - 232
EFFECT OF NOVEL RATIONALLY DESIGNED NAPHTOQUINONESDERIVED DRUGS ON LUNG CANCER CELL LINES. ALICE LASCHUK HERLINGER, IURI
CORDEIRO VALADAO, RENATA DALMASCHIO DALTOÉ, KLESIA PIROLA MADEIRA,
JOÃO FRANCISCO ALLOCHIO FILHO, LUCAS CUNHA DIAS DE REZENDE, MURILO
FANCHIOTTI CERRI, SARAH FERNANDES TEIXEIRA, PAULO CILAS MORAIS LYRA
JUNIOR, SANDRO JOSÉ GRECO, LETICIA BATISTA AZEVEDO RANGEL
B - 250
ANTI-FGF2 MONOCLONAL ANTIBODY AS AN IMAGING AND
ANTITUMOR APPROACH FOR MURINE MELANOMA B16-F10. RODRIGO BARBOSA
DE AGUIAR, CAROLINA BELLINI PARISE, ROGER CHAMMAS, JANE ZVEITER DE
MORAES
B - 233
CITOTOXIC EFFECTS OF ANTHRACYCLINES IN HUMAN FIBROBLASTS
DEFICIENT IN NUCLEOTIDE EXCISION REPAIR. LARISSA MILANO DE SOUZA,
TEMENOUGA NIKOLOVA GUESHEVA, GUIDO LENZ, JENIFER SAFFI
B - 251
CELL DEATH AND IN VIVO MELANOMA TUMOR GROWTH
REMISSION DETERMINED BY A SNAKE TOXIN WITH SPECIFICITY FOR ACTIVELY
PROLIFERATING CELLS. MIRIAN A F HAYASHI, FABIO D NASCIMENTO, LUCIE
SANCEY, ALEXANDRE PEREIRA, EDUARDO B OLIVEIRA, HELENA B NADER, IVARNE
LS TERSARIOL, JEAN-LUC COLL, IRINA KERKIS
B - 234
NEW BENZOTHIAZOLE INDUCES GENOTOXICITY IN GASTRIC
CANCER CELL LINE BUT NOT IN NORMAL CELLS. BRUNO MOREIRA SOARES,
LEILANE DE HOLANDA BARRETO, JORGE AMANDO BATISTA RAMOS, SIVANNE
BRAGA DE ALMEIDA, VITOR FRANCISCO FERREIRA, NOGUEIRA, A.F., AZEVEDO,
E.C., ROMMEL MARIO RODRIGUÉZ BURBANO, TATIANA VASCONCELOS, MARNE
CARVALHO DE VASCONCELLOS, RAQUEL CARVALHO MONTENEGRO
B - 235
STUDY THE INVOLVEMENT OF METAL PEPTIDASE PHEX IN
SQUAMOUS CELL CARCINOMA. RAQUEL LEÃO NEVES, DANIELA B. ZANATTA,
LARISSA P. COPPINI, BRYAN E. STRAUSS, JOÃO B. PESQUERO, FÁBIO D.
NASCIMENTO, IVARNE L. TERSARIOL, HELENA B. NADER, ADRIANA K. CARMONA,
NILANA M. T. BARROS
B - 236
IONIZING RADIATION INDUCES AKT PHOSPHORYLATION AND MIR210 EXPRESSION IN A RADIORESISTANT GLIOBLASTOMA CELL LINE. PAULA
SABBO BERNARDO, GISELLE PINTO DE FARIA, RAQUEL CIUVALSCHI MAIA
B - 237
UPREGULATION OF APE/REF-1 EXPRESSION INDUCED BY
ENDOPLASMIC RETICULUM STRESS. CLARISSA LEAL DE OLIVEIRA MELLO, LUCIANA
BARRETO CHIARINI
B - 238
EVALUATION OF THE CELLULAR RESPONSE OF SPECIES CEBUS
APELLA EXPOSED TO CARCINOGEN N-METHYL-N-NITROSOUREA (MNU) AND
TREATED WITH CANOVA®. DANIELLE CRISTINNE AZEVEDO FEIO, JOSÉ AUGUSTO
PEREIRA CARNEIRO MUNIZ, ROMMEL MÁRIO RODRIGUEZ BURBANO, LACY
CARDOSO DE BRITO JUNIOR, PATRÍCIA DANIELLE LIMA DE LIMA
B - 239
LIPID DROPLETS ARE SITES OF THE MTOR PATHWAY IN COLON
CANCER CELLS. NARAYANA FAZOLINI BASTOS, JOÃO PAULO DE BIASO VIOLA,
PATRÍCIA TORRES BOZZA, CLARISSA MENEZES MAYA-MONTEIRO
B - 240
EHMT1 AND EHMT2 METHYLTRANSFERASES EXPRESSION
ANALYSIS IN BREAST CANCER CELL LINES. MARTHA SILVA ESTRELA, CAROLINA
B - 252
MT1-MMP AS A MOLECULAR MARKER DURING THE FIRST STAGES
OF PROGRESSION OF THE COLON CANCER IN RATS. ELIAKIN ROBERTO DO
CARMO, ROSIANE CRISTINA ALVES, JAIME RIBEIRO FREITAS, JÉSSICA DA SILVA,
KAMILA CAROLINE CAMARGO, PEDRO DUARTE NOVAES, CARLA CRISTINE
KANUNFRE, MARIA ALBERTINA DE MIRANDA SOARES, JOSE ROSA GOMES
C – Cell Biology and
Inflammation
C1-C118
C-1
EFFECTS OF ANTI-CD3 MONOCLONAL ANTIBODY IN SALIVARY
GLANDS OF SPONTANEOUSLY DIABETIC MICE. EBER EMANUEL MAYORAL,
GABRIEL MORETTI DOMINGUES, ALAN TELLES FERRI, RAFAEL DIAS MANCIO,
FERNANDA ALVAREZ ROJAS, LUIS ANTONIO PERONI, EDMIR AMERICO LOURENÇO,
EDUARDO JOSE CALDEIRA
C-2
MELANOMACROPHAGES IN THE SPLEEN OF EUPEMPHIX
NATTERERI (ANURA: LEIUPERIDAE): RESPONSES TO LPS. LILIAN FRANCO-BELUSSI,
GABRIELA BARONI LEITE, JULIANE SILBERSCHIMDIT FREITAS, CLASSIUS DE
OLIVEIRA
C-3
FPR RECEPTOR MEDIATES THE ANTI-INFLAMMATORY ACTIONS OF
ANNEXIN A1 PROTEIN IN ENDOTOXIN-INDUCED UVEITIS. ANA PAULA GIROL,
CRISTIANE DAMAS GIL, SONIA MARIA OLIANI
97
C-4
DNA DAMAGE IN BLOOD OF THE COPD PATIENTS BY COMET
ASSAY. HELEN TAIS DA ROSA, ANDRÉA LÚCIA GONÇALVES DA SILVA, MARTIELE
BIZARRO, EDUARDA BENDER, PAULO RICARDO DA ROSA, CLARA FORRER
CHARLIER, MIRIAM SALVADOR, DINARA JAQUELINE MOURA, ANDRÉIA ROSANE DE
MOURA VALIM, NIKOLOVA TEMENOUGA GUECHEVA, JOÃO ANTONIO PEGAS
HENRIQUES
C-5
RU486 IMPROVES CUTANEOUS WOUND HEALING IN MICE
SUBMITTED TO PSYCHOLOGICAL STRESS. TAIS FONTOURA DE ALMEIDA, ANDRÉA
MONTE ALTO COSTA
C-6
MODULATION OF PROSTATE SMOOTH MUSCLE CELL RESPONSE TO
BACTERIAL LPS BY TESTOSTERONE. CAROLINA LEIMGRUBER, AMADO QUINTAR,
CRISTINA ALICIA MALDONADO
C-7
ANALYSIS OF THE INFLAMMATORY PROFILE IN TYPE 1 AND 2 IN
BLOOD AND LESIONS OF MOUSE INFECTED WITH AMERICAN CUTANEOUS
LEISHMANIASIS. FLÁVIA PERRIM DE MELO, FÁBIO RIBEIRO QUEIROZ, ANA
CRISTINA CARVALHO DE BOTELHO, JOSIANE BARBOSA PIEDADE, LUCIANA MARIA
SILVA
C-8
INFLUENCE
OF
CYCLOOXYGENASE-2
INHIBITION
ON
INTRAMEMBRANOUS AND ENDOCHONDRAL BONE GRAFTS INCORPORATION:
IMUNOHISTOCHEMISTRY ANALYSIS. CLÁUDIA CRISTINA BIGUETTI, EDUARDO
MORESCHI, LEANDRO DE ANDRADE HOLGADO, APARÍCIO FIUZA DE CARVALHO
DEKON, PAULO DOMINGOS RIBEIRO JUNIOR, MARIZA AKEMI MATSUMOTO
C - 22
SENSING ENDOPLASMIC RETICULUM STRESS BY PROTEIN KINASE
RNA-LIKE ENDOPLASMIC RETICULUM KINASE PROMOTES ADAPTIVE
MITOCHONDRIAL DNA BIOGENESIS AND CELL SURVIVAL VIA HEME OXYGENASE1/CARBON MONOXIDE ACTIVITY. HUN TAEG CHUNG, MIN ZHENG, SEUL-KI KIM,
YEONSOO JOE, SUNG HOON BACK
C - 23
INHIBITION OF ROCK PROMOTES RESOLUTION OF INFLAMMATION
BY ENHANCING NEUTROPHIL APOPTOSIS. RAYSSA MACIEL ATHAYDE, ALESANDRA
CORTE REIS, VANESSA PINHO DA SILVA, MAURO MARTINS TEIXEIRA
C - 24
NANOCOMPOSITE TREATMENT REDUCES THE SEVERITY OF THE
INFLAMMATORY RESPONSE ASSOCIATED WITH ACUTE GRAFT VERSUS HOST
DISEASE (GVHD) IN MICE. PRISCILA TELES DE TOLÊDO BERNARDES, BÁRBARA
MAXIMINO REZENDE, MARINA GOMES MIRANDA E CASTOR ROMERO, DANIELLE
SOUZA G, MAURÍCIO VELOSO BRANT PINHEIRO, VANESSA PINHO, MAURO
MARTINS TEIXEIRA
C - 25
EFFECTS OF HIGH-CARBOHYDRATE DIET IN THE INCREASED
EPIDIDYMAL ADIPOSE TISSUE AND THE RECRUITMENT OF INFLAMMATORY CELLS
IN MICE. PRISCILA TELES DE TOLÊDO BERNARDES, BÁRBARA MAXIMINO REZENDE,
MAURO MARTINS TEIXEIRA, VANESSA PINHO, ADALIENE VERSIANI MATOS
C - 26
ANNEXIN A1 PROMOTES RESOLUTION OF ACUTE INFLAMMATION
BY INDUCING NEUTROPHIL APOPTOSIS. JULIANA PRISCILA VAGO DA SILVA,
CAMILA RODRIGUES CHAVES NOGUEIRA, LUCIANA PÁDUA TAVARES, THAÍS ROLLA
DE CAUX, FREDERICO MARIANETTI SORIANI, FERNANDO LOPES, REMO DE CASTRO
RUSSO, VANESSA PINHO, MAURO MARTINS TEIXEIRA, LIRLÂNDIA PIRES DE SOUSA
C-9
INCREASE OF TRYPTASE MAST CELL LEADS TO DENERVATION IN
INFECTED INDIVIDUALS WITH AND WITHOUT CHAGASIC MEGAESOPHAGUS.
PATRÍCIA ROCHA MARTINS, RODOLFO DUARTE NASCIMENTO, JACQUELINE
GARCIA DUARTE, SHEILA ADAD, DÉBORA D’ÀVILA REIS
C - 27
EFFECTS OF THE SYMPATHETIC-PERIPHERAL CRH-HISTAMINE AXIS
IN THE IMMUNOLOGICAL FUNCTION OF MACROPHAGES. PATRÍCIA RENCK
NUNES, PAULO IVO HOMEM DE BITTENCOURT JÚNIOR
C - 10
TRAINING EFFECTS ON THE GOBLET CELLS NUMBER AND
INTESTINAL ALKALINE PHOSPHATASE EXPRESSION IN GMS OBESE RATS.JAIME
RIBEIRO FREITAS, MARIA ALBERTINA DE MIRANDA SOARES, NAYARA DE
CARVALHO LEITE, SABRINA GRASSIOLLI, JOSÉ ROSA GOMES
C - 28
DETRIMENTAL ROLE OF INTERLEUKIN-4 IN ACETAMINOPHENINDUCED ACUTE LIVER FAILURE. DANIELE ARAÚJO PIRES, PEDRO ELIAS MARQUES,
SYLVIA STELLA MARQUES, JAYANE LAÍS QUINTÃO, LINDSLEY FERREIRA GOMIDES,
GUSTAVO BATISTA MENEZES
C - 11
THE INFLUENCE OF PROTEIN MALNUTRITION ON THE IL-1Β
PRODUCTION BY MACROPHAGES STIMULATED WITH TNF-Α. DALILA CUNHA DE
OLIVEIRA, ALEXANDRA SIQUEIRA MELLO, JACKELINE SOARES OLIVEIRA BELTRAN,
ED WILSON DOS SANTOS, PRIMAVERA BORELLI, RICARDO AMBRÓSIO FOCK
C - 29
EVALUATION OF IMMUNOGENICITY OF THE CANDIDATE PHAGES
TO USE IN PHAGE THERAPY AND ANALYSIS OF CROSS-REACTION BY SPECIFIC
ANTIBODIES. ROBERTO SOUSA DIAS, VINÍCIUS DUARTE SILVA, FLÁVIA DE OLIVEIRA
SOUZA, LÍVIA CARNEIRO FIDÉLIS SILVA, LEANDRO LICURSI DE OLIVEIRA, EDUARDO
DE ALMEIDA MARQUES SILVA, CYNTHIA CANEDO SILVA, SÉRGIO OLIVEIRA DE
PAULA
C - 12
CAFFEIC ACID PHENETHYL ESTER (CAPE) IMPROVES THIRD-DEGREE
BURNS HEALING IN RATS. JEANINE SALLES DOS SANTOS, ANDRÉA MONTE-ALTO
COSTA
C - 13
NEUTROPHIL RECRUITMENT TO THE SKELETAL MUSCLE AFTER
EXERCISE TO FATIGUE IS ASSOCIATED TO PRODUCTION OF ROS. ALBENÁ NUNES
DA SILVA, PRISCILA TELES DE TOLEDO BERANARDES, BARBARA MAXIMINO
REZENDE, FERNANDO LOPES, MAURO MARTINS TEIXEIRA, VANESSA PINHO
C - 30
EFFECTS OF THE STIMULATION OF INFLAMMATION AND
TREATMENT WITH ANXA1 PROTEIN IN THE HUMAN RETINAL PIGMENT
EPITHELIAL CELLS. LAILA TONIOL CARDIN, NATHÁLIA MARTINS SONEHARA,
KALLYNE KIOKO MIMURA, LAÍS SOBRAL, ANDRÉIA MACHADO LEOPOLDINO, SONIA
MARIA OLIANI, FLÁVIA CRISTINA RODRIGUES LISONI
C - 14
LEPTIN EFFECTS ON LEUKOCYTES ON OBESE MICE. GLAUCIA SOUZA
ALMEIDA, SALLY LIECHOCKI, LOHANNA PALHINHA DO AMARAL, PATRICIA TORRES
BOZZA, CLARISSA M. MAYA-MONTEIRO
C - 31
OXIDIZED-LDL AND PARAOXONASE-1 IN THE ASSOCIATION
BETWEEN CORONARY ARTERY DISEASE AND SLEEP DISORDERED BREATHING.
FERNANDA SCHÄFER HACKENHAAR, DENIS MARTINEZ, TÁSSIA MACHADO
MEDEIROS, CRISTINI KLEIN, PAULO V.G. ALABARSE, MARA S. BENFATO
C - 15
CXCR2 AND FPR1 ACTIVATION STIMULATE NEUTROPHILMEDIATED INJURY DURING ACETAMINOPHEN-INDUCED ACUTE LIVER FAILURE.
PEDRO ELIAS MARQUES, SYLVIA STELLA AMARAL, DANIELE ARAUJO PIRES, LAURA
LOPES NOGUEIRA, MAURO MARTINS TEIXEIRA, GUSTAVO BATISTA MENEZES
C - 32
OBESITY AS AN ADDITIONAL COMPLICATION FACTOR IN SEPSIS
INDUCED PULMONARY INFLAMMATION. THAIS PINEDA FUNGARO, RICARDO
COSTA PETRONI, SUELEN JERÔNYMO SOUZA DE OLIVEIRA, DENISE FREDIANE
BARBEIRO, FRANCISCO GARCIA SORIANO, THAIS MARTINS DE LIMA-SALGADO
C - 16
ESTABLISHMENT
OF
THE
OPTIMAL
CONDITIONS
TO
DIFFERENTIATE THE HUMAN U937 CELLS INTO M1 OR M2 MACROPHAGES TO BE
USED AS IN VITRO EXPERIMENTAL MODEL FOR BIOMEDICAL STUDIES. MARCO
ANTÔNIO DE BASTIANI, MATHEUS BECKER FREITAS, LEONARDO LISBÔA DA
MOTTA, FERNANDA FRANÇA, FÁBIO KLAMT, MELISSA MARKOSKI, CAROLINA
BEATRIZ MÜLLER
C - 33
INFLAMMATORY CELLS PROFILE IN CARDIAC MUSCLE OF CALOMYS
CALLOSUS INFECTED WITH TRYPANOSOMA CRUZI IN THE CHRONIC PHASE OF
INFECTION. NOEMI NOSOMI TANIWAKI, VANESSA GALDENO FREITAS, CIBELE
RODELLA ALMEIDA, DEBORAH YAMAZAKI HUKUDA, MARIA CRISTINA RODRIGUES
MEDEIROS, ANGELA BATISTA GOMES DOS SANTOS
C - 17
EXPRESSION PATTERN OF PRO-INFLAMMATORY CYTOKINES IN
MSCS FROM GALLUS GALLUS. GABRIHEL STUMPF VIEGAS, RAQUEL CALLONI,
PATRICK TÜRCK, DIEGO BONATTO, ELVIRA CORDEIRO
C - 34
FEMALE MICE SHOW INCREASED LEUKOCYTE RECRUITMENT IN
ADIPOSE TISSUE THAN MALE MICE IN A FOOD ALLERGY MODEL. RAFAELA VAZ
SOUSA PEREIRA, NATHÁLIA VIEIRA BATISTA, ROBERTA CRISTELLI FONSECA, DENISE
ALVES PEREZ, DÉBORA MOREIRA ALVARENGA, DENISE CARMONA CARA
C - 18
INDUCTION OF EOSINOPHIL APOPTOSIS BY HYDROGEN PEROXIDE
PROMOTES THE RESOLUTION OF ALLERGIC INFLAMMATORY RESPONSE.
ALESANDRA CORTE REIS, RAYSSA MACIEL ATHAYDE, THIAGO VINICIUS ÁVILA,
JULIANA PRISCILA VAGO, MILENE ALVARENGA RACHID, MAURO MARTINS
TEIXEIRA1, VANESSA PINHO
C - 35
TEMPORAL
EVALUATION
OF
THE
METABOLIC
AND
IMMUNOLOGICAL CONSEQUENCES IN AN EXPERIMENTAL MODEL OF FOOD
ALLERGY. NATHÁLIA VIEIRA BATISTA, RAFAELA VAZ SOUSA PEREIRA, ROBERTA
CRISTELLI FONSECA, ADALIENE VERSIANI MATOS FERREIRA, DENISE CARMONA
CARA
C - 19
EVALUATION OF LACTOCOCCUS LACTIS SECRETING OR NOT HSP 65
TREATMENT AS STRATEGY OF FOOD ALLERGY IMMUNOMODULATION. DENISE
ALVES PEREZ, DÉBORA MOREIRA ALVARENGA, NATHÁLIA VIEIRA BATISTA,
RAFAELA VAZ DE SOUZA PEREIRA, ROBERTA CRISTELLI FONSECA, ANA CRISTINA
GOMES SANTOS, ANA MARIA CAETANO DE FARIA, ANDERSON MIYOSHI, GUSTAVO
BATISTA DE MENEZES, DENISE CARMONA CARA
C - 36
INFLUENCE OF PANCREATIC ACINAR CELL NECROSIS ON STELLATE
CELL PROLIFERATION IN VITRO. BURKHARD KRUEGER, KRISTINA GEISSLER
C - 20
EFFECTS OF CHLOROQUINE TREATMENT ON THE MOUSE IMMUNE
SYSTEM. RODOLFO THOMÉ, ALESSANDRO DOS SANTOS FARIAS, FÁBIO TRINDADE
MARANHÃO COSTA, LIANA VERINAUD
C - 37
PARTICIPATION OF PROINFLAMMATORY CYTOKINES AND CELL
MIGRATION IN THE ANTI-INFLAMMATORY EFFECTS OF A SULFATED
POLYSACCHARIDE FRACTION EXTRACTED FROM THE MARINE ALGAE GRACILARIA
CAUDATA IN MICE. LUCAS ANTONIO DUARTE NICOLAU., RENAN OLIVEIRA SILVA,
LARISSE TAVARES LUCETTI, ANA PAULA MACEDO SANTANA, ANDRE LUIZ DOS REIS
BARBOSA, KAROLINE SABÓIA ARAGÃO, RONALDO DE ALBUQUERQUE RIBEIRO,
MARCELLUS HENRIQUE LOIOLA PONTE DE SOUZA, JAND-VENES ROLIM MEDEIROS
C - 21
EFFECT OF LOW LEVEL LASER THERAPY ON THE VIABILITY OF
MACROPHAGES ACTIVATED WITH LPS. LUIZA GABRIELA BARROS, NADHIA HELENA
COSTA SOUZA, JANE PATRÍCIA DE MELO HAYASHI, RAQUEL AGNELLI MESQUITA
FERRARI, SANDRA KALIL BUSSADORI, KRISTIANNE PORTA SANTOS FERNANDES
C - 38
NITRIC OXIDE REDUCES ALENDRONATE-INDUCED GASTRIC
DAMAGE IN RATS: ROLE OF CYTOKINES AND OXIDATIVE STRESS. LUCAS ANTONIO
DUARTE NICOLAU., RENAN OLIVEIRA SILVA, NATÁLIA RODRIGUES D’ARC COSTA,
LARISSE TAVARES LUCETTI, ANDRE LUIZ DOS REIS BARBOSA, ANA PAULA MACEDO
98
SANTANA, KAROLINE SABÓIA ARAGÃO, RONALDO DE ALBUQUERQUE RIBEIRO,
MARCELLUS HENRIQUE LOIOLA PONTE DE SOUZA, JAND-VENES ROLIM MEDEIROS
C - 39
HOW DOES THE PLATELET-ACTIVATING FACTOR ACT IN FOOD
ALLERGY? ROBERTA CRISTELLI FONSECA, NATHÁLIA VIEIRA BATISTA, RAFAELA VAZ
SOUSA PEREIRA, DENISE ALVES PEREZ, DÉBORA MOREIRA ALVARENGA, VANESSA
PINHO, DENISE CARMONA CARA
C - 40
IMPROVEMENT OF SKIN WOUND HEALING BY PARENTERAL
INJECTION OF TOLERATED PROTEINS INTO ORALLY TOLERANT MICE. RAQUEL
ALVES COSTA, LIANA BIAJOLLI O. MATOS, GREGORY THOMAS KITTEN, NELSON
MONTEIRO VAZ, CLÁUDIA ROCHA CARVALHO
C - 41
EFFECTS OF LOW LEVEL LASER THERAPY ON THE CREATINE KINASE
ACTIVITY IN C2C12 CELLS. JEAN LUCAS PARPINELLI BARBOSA, MIKAELE TAVARES
SILVA, PAOLA PELEGRINELI ARTILHEIRO, KRISTIANNE PORTA SANTOS FERNANDES,
SANDRA KALIL BUSSADORI, RAQUEL AGNELLI MESQUITA-FERRARI
C - 42
MOLECULAR FEATURES OF ANEMIA AND OBESITY. THAÍS DA
FONTE FARIA, SIMONE VARGAS DA SILVA, THEREZA CHRISTINA BARJA FIDALGO,
MARTA CITELLI DOS REIS
C - 43
IMPROVEMENT OF SKIN WOUND HEALING BY PARENTERAL
INJECTION OF A REGULAR DIET COMPONENT (ZEIN). THIAGO CANTARUTI
ANSELMO, RAQUEL ALVES COSTA, NELSON MONTEIRO VAZ, CLAUDINEY
MELQUIADES RODRIGUES, KÊNIA SOARES DE SOUZA, CLAUDIA ROCHA CARVALHO
C - 44
ALPHA-MELANOCYTE
STIMULATING
HORMONE
REDUCE
INFLAMMATORY CELL COUNT AFTER EXCISIONAL CUTANEOUS WOUND. KÊNIA
SOARES DE SOUZA, GERALDO MAGELA DE AZEVEDO JUNIOR, RAQUEL ALVES
COSTA, CLAUDINEY MELQUIADES RODRIGUES, THIAGO CANTARUTI ANSELMO,
NELSON MONTEIRO VAZ, CLÁUDIA ROCHA CARVALHO
C - 45
TOLL LIKE RECEPTORS 2 AND 4 LEAD TO CARDIOMYOCYTE
HYPERTROPHY IN VITRO. FERNANDA GAISLER DA SILVA, MARCELA SORELLI
CARNEIRO RAMOS
C - 46
RENAL ISCHEMIA/REPERFUSION INDUCED CARDIAC HYPERTROPHY
IN MICE: INCREASED GENE EXPRESSION OF HSP 60 AND 70, TOLL-LIKE RECEPTOR
LIGANDS. MAYRA TRENTIN SONODA, MARCELA SORELLI CARNEIRO RAMOS
C - 47
EFFECTS OF OLEIC AND LINOLEIC ACIDS ON KERATINOCYTES.
GILSON MASAHIRO MURATA, RUI CURI, ELAINE HATANAKA
C - 48
IMPACT OF PERIODONTAL STATUS ON MUSCLE REPAIR PROCESS
OF SEDENTARY AND TRAINED WISTAR RATS. BÁRBARA CAPITANIO DE SOUZA,
MARCELO LAZZARON LAMERS, ALESSANDRA MAGNUSSON, MARCELO EKMAN
RIBAS, ANDRÉ LUIZ LOPES, BRUNO COSTA TEIXEIRA
C - 49
APOLIPOPROTEIN E COG 133 MIMETIC PEPTIDE ATTENUATES 5FLUOROURACIL-INDUCED INTESTINAL MUCOSITIS IN VITRO AND IN VIVO.
ORLEÂNCIO GOMES RIPARDO DE AZEVEDO, JARDLON ALBINO COSTA, CELINA
VIANA DE ARAÚJO, HERENE BARROS MIRANDA LUCENA, ROBERTO CÉSAR P. LIMAJÚNIOR, RENATO ANDRÉ C. OLIVEIRA, BRUNA CASTRO OLIVEIRA, MICHEL P. VITEK,
RICHARD L. GUERRANT, RONALDO ALBUQUERQUE RIBEIRO, DEYSI VIVIANA T.
WONG, TIÊ BEZERRA COSTA, SNJEZANA ZALA-MILATOVIC, REINALDO BARRETO
ORIÁ
C - 50
EFFECTS OF ZINC SUPPLEMENTATION ON GROWTH, INTESTINAL
BACTERIAL TRANSLOCATION, AND PRO-INFLAMMATORY CYTOKINES IN WISTAR
RATS CHALLENGED BY UNDERNUTRITION AND LACTOSE-INDUCED OSMOTIC
DIARRHEA. ANITA MAYARA FEITOSA SANTOS, CAMILA DE ALBUQUERQUE
ALMEIDA, PRISCILA BRISENO FROTA, SAID GONÇALVES DA CRUZ FONSECA, ÍTALO
LEITE FIGUEIREDO, KAROLINE SABOIA ARAGÃO, CARLOS EMANUEL C.
MAGALHÃES, CIBELE BARRETO MANO DE CARVALHO, REINALDO BARRETO ORIÁ
C - 51
INFLIXIMAB
ATTENUATES
BONE
RESORPTION
AND
INFLAMMATORY OSTEOLYSIS IN A MODEL OF EXPERIMENTAL PERIODONTITIS IN
WISTAR RATS. RAKEL DE CASTRO EVANGELISTA, DAVI DA CUNHA GONÇALVES,
ANITA MAYARA FEITOSA SANTOS, RAFAEL REIS DA SILVA, GERLY ANNE DE CASTRO
BRITO, RENATA DE CARVALHO LEITÃO, REINALDO BARRETO ORIÁ
C - 52
MACROPHAGE EFFECTS IN THE NEPHROTOXICITY PROCESS
CAUSED BY IMMUNOSUPPRESSANT CYCLOSPORINE A: EXPRESSIONS OF TNFALFA AND ANNEXIN A1. AYLA BLANCO POLTRONIERI, CARLA PATRÍCIA CARLOS,
EMMANUEL DE ALMEIDA BURDMANN, SONIA MARIA OLIANI
C - 53
A SNAKE VENOM SECRETED PHOSPHOLIPASE A2 CROSSTALKS
WITH INTRACELLULAR PHOSPHOLIPASES TO INDUCE MAST CELLS (MCS)
DEGRANULATION. MARLOS CORTEZ SAMPAIO, BRUNO LOMONTE, JOSÉ MARIA
GUTIERREZ, CATARINA TEIXEIRA
C - 54
EVALUATION OF MACROPHAGE INFILTRATION IN ADIPOSE TISSUE
OF EX-OBESE PATIENTS AND ROLE OF MESENCHYMAL STROMAL CELLS ON THE
IMMUNOPHENOTYPE OF MACROPHAGES. DAIANA VIEIRA LOPES, CESAR S.
CLÁUDIO-DA-SILVA, MARCELO C.A. SOUZA, MORENA P. DIAS, HÉLIO DOS SANTOS
DUTRA, RADOVAN BOROJEVIC, CHRISTINA MAEDA TAKIYA, M. ISABEL DORIA
ROSSI
C - 55
COMPARATIVE EFFECTS OF EPA AND DEFLAZACORT ON
DYSTROPHIN-DEFICIENT MUSCLE FIBERS OF THE MDX MICE. LETICIA
MONTANHOLI APOLINARIO, SAMARA CAMAÇARI DE CARVALHO, HUMBERTO
SANTO NETO, MARIA JULIA MARQUES
C - 56
EFFECT OF PHOTOBIOMODULATION USING DIFFERENT ENERGY
DENSITIES ON PROLIFERATION OF C2C12 SKELETAL MUSCLE CELLS DURING
DIFFERENTIATION PROCESS. MIKAELE TAVARES DA SILVA, JEAN LUCAS PARPINELLI
BARBOSA, PAOLA PELEGRINELI ARTILHEIRO, SANDRA KALIL BUSSADORI,
KRISTIANNE PORTA SANTOS FERNANDES, RAQUEL AGNELLI MESQUITA-FERRARI
C - 57
A PHOSPHOLIPASE A2 (CBR) ISOLATED FROM VENOM OF
CROTALUS DURISSUS RURUIMA INDUCES LIPID BODY (LB) FORMATION IN
MACROPHAGES. ANA EDUARDA ZULIM DE CARVALHO, KARINA CRISTINA
GIANNOTTI, ELBIO LEIGUEZ JUNIOR, MÁRCIO HIDEKI MATSUBARA, CONSUELO
LATORRE FORTES DIAS, MARIA CRISTINA DOS SANTOS, CATARINA TEIXEIRA
C - 58
EFFECT OF ACTIVATION ON THE VIABILITY OF J774
MACROPHAGES. JANE PATRICIA DE MELO HAYASHI, NADHIA HELENA COSTA
SOUZA, LUIZA GABRIELA BARROS, RAQUEL AGNELLI MESQUITA FERRARI, SANDRA
KALIL BUSSADORI, KRISTIANNE PORTA SANTOS FERNANDES
C - 59
LIPID BODIES FORMATION INDUCED BY A SNAKE VENOM
PHOSPHOLIPASE A2 (CB) IS RELATED TO INCREASED PGE2 BIOSYNTHESIS IN
MACROPHAGES. KARINA CRISTINA GIANNOTTI, ELBIO LEIGUEZ JUNIOR, NEIDE
GALVÃO DO NASCIMENTO, ANA EDUARDA ZULIM DE CARVALHO, CONSUELO
LATORRE FORTES-DIAS, RENATA HAGE, CATARINA TEIXEIRA
C - 60
EFFECTS OF EICOSAPENTAENOIC ACID (EPA) ON M1 AND M2
MACROPHAGE POPULATIONS IN SKELETAL MUSCLES OF THE MDX MICE.
SAMARA CAMAÇARI DE CARVALHO, LETÍCIA MONTANHOLI APOLINÁRIO,
HUMBERTO SANTO NETO, SELMA MARIA MICHELIN MATHEUS, MARIA JÚLIA
MARQUES
C - 61
THE DEVELOPMENT OF ENDOMETRIOTIC LESIONS IN
HETEROLOGOUS MODEL USING MICE THAT EXPRESS A GREEN FLUORESCENT
PROTEIN (GFP): ANALYSIS OF THE ANGIOGENESIS PROCESSES. JOÃO MARCOS
PEREIRA SANTOS, THAIS ANGELI GAMBA, KARINA CRISTINA RODRIGUEZ BAPTISTA,
ANTÔNIO PALUMBO, LEONARDO BOLDRINI, RÔMULO MEDINA MATOS, JAMILA
ALESSANDRA PERINI, LUIZ EURICO NASCIUTTI, DANIEL ESCORSIM MACHADO
C - 62
EFFECT OF LOW LEVEL LASER THERAPY ON THE PROLIFERATION OF
INFLAMMATORY MACROPHAGES. NADHIA HELENA COSTA SOUZA, LUIZA
GABRIELA BARROS, JANE PATRÍCIA DE MELO HAYASHI, RAQUEL AGNELLI
MESQUITA FERRARI, DANIELA DE FÁTIMA TEIXEIRA DA SILVA, SANDRA KALIL
BUSSADORI, KRISTIANNE PORTA SANTOS FERNANDES
C - 63
DEVELOPMENT OF IN VITRO ALTERNATIVE METHODS TO PREDICT
ALLERGENIC POTENTIAL OF CHEMICAL AGENTS. JANE ZVEITER DE MORAES,
VANESSA M. SÁ-ROCHA, JANE ZVEITER DE MORAES
C - 64
STUDY OF ANTI-INFLAMMATORY ACTIONS OF METHYL GALLATE.
TATIANA ALMEIDA PÁDUA, BIANCA SUELEN DA SILVA CRUZ DE ABREU, MARCIA
VIDAL DE CARVALHO, MARIA RAQUEL FIGUEREIDO, MARIA DAS GRAÇAS
HENRIQUES, ELAINE CRUZ ROSAS
C - 65
INCREMENT OF MAST CELLS, NEOVASCULARIZATION AND
ACTIVATION OF NFΚB IN THE ACHILLES TENDON OF RATS WITH EXPERIMENTAL
DIABETES. RODRIGO RIBEIRO DE OLIVEIRA, YURI RODRIGUES ROCHA, ALLYSSON
BRUNO RAPHAEL BRAGA, GERLY ANNE DE CASTRO BRITO, LUIZ EURICO NASCIUTTI
C - 66
AMYLOID FIBRILS INDUCE NEUTROPHIL EXTRACELLULAR TRAPS
(NETS) FORMATION BY HUMAN NEUTROPHILS AND ARE DIGESTED BY ELASTASE.
ANDERSON GUIMARÃES BAPTISTA COSTA, ESTEFÂNIA PEREIRA CARDOSO
AZEVEDO, GUILHERME TOREZANI, CAROLINA AZEREDO BRAGA, FERNANDO LUCAS
PALHANO, JEFFERY KELLY, ELVIRA SARAIVA, DEBORA FOGUEL
C - 67
ATTRACTING
CHEMOKINES
EXPRESSION
FOR
POLYMORPHONUCLEAR CELLS IN WHITE ADIPOSE TISSUE FROM CANCER
CACHEXIA RATS. FELIPE HENRIQUES, FELIPE FRANCO, PAMELA KNOB, KALTINAITE
BENETON, RODRIGO XAVIER, CLAUDIO SHIDA, ROGERIO SERTIÉ, SIDNEY PERES,
MIGUEL BATISTA JR
C - 68
BOTHROPIC TOXIN MODULATES INFLAMMATORY ANGIOGENESIS
IN MICE. PUEBLA CASSINI VIEIRA, AMANDA VIEIRA, SAULO ANTONIO GOMES
FILHO, SIMONE RAMOS DECONTE, FABIO DE OLIVEIRA, FERNANDA DE ASSIS
ARAÚJO
C - 69
ATLA, AN ASPIRIN-TRIGGERED LIPOXIN A4 SYNTHETIC ANALOG, IN
THE TREATMENT OF FIBROTIC EFFECTS OF BLEOMYCIN-INDUCED LUNG
DAMAGE. RAFAEL DE FREITAS GUILHERME, DEBORA GONÇALVES XISTO, PATRICIA
RIEKEN MACEDO ROCCO, IOLANDA MARGHERITA FIERRO, CLAUDIO DE AZEVEDO
CANETTI, CLAUDIA FARIAS BENJAMIM
C - 70
THE ROLE OF LAMININ POLYMER IN SPLENIC DENDRITIC CELLS.
LEANDRO LADISLAU ALVES, AMANDA REGINA DA FÉ, STEVEN L KUNKEL, THEREZA
CHRISTINA BARJA FIDALGO, WILSON SAVINO, CLAUDIA FARIAS BENJAMIM
C - 71
ANTI-INFLAMMATORY EFFECTS OF GALECTIN-1 PROTEIN ON
LIPOPOLYSACCHARIDE-CHALLENGED CULTURED HUMAN RETINAL PIGMENT
EPITHELIAL CELLS. NATHÁLIA MARTINS SONEHARA, LAILA TONIOL CARDIN,
CRISTIANE DAMAS GIL, SONIA MARIA OLIANI
C - 72
INVESTIGATION OF MAST CELL HETEROGENEITY AND EXPRESSION
OF ANTI-INFLAMMATORY PROTEIN ANNEXIN A1 IN ENDOMETRIOSIS. RUBENS DE
PAULA JUNIOR, POATAN DA SILVA PINOTI, ANTONIO HELIO OLIANI, DENISE
CRISTINA MOS VAZ, SOLANGE CORREA GARCIA P D”AVILA, SONIA MARIA OLIANI,
CRISTIANE DAMAS GIL
99
C - 73
EFECT OF STEROID AND NON-STEROID ANTI-INFLAMMATORY
COMPOUNDS ON S100B SECRETION IN PRIMARY ASTROCYTE CULTURES
EXPOSED OR NOT TO LPS. ELISA NEGRI, CAROLLINA FRAGA DA RÉ, FABIANA
GALLAND, MARIA CRISTINA GUERRA, MARINA CONCLI LEITE, CARLOS ALBERTO
GONÇALVES
C - 74
LOVASTATIN DECREASES NEUROINFLAMMATION AND PREVENTS
COGNITIVE IMPAIRMENT AFTER CEREBRAL MALARIA. PATRICIA ALVES REIS,
TATHIANY IGREJA DA SILVA, EDSON FERNANDES DE ASSIS, PATRICIA TORRES
BOZZA, FERNANDO AUGUSTO BOZZA, HUGO CAIRE DE CASTRO FARIA NETO
C - 75
UNRAVELING A NEW CELLULAR MECHANISM BEHIND
TRANSTHYRETIN-RELATED LEPTOMENINGEAL AMYLOIDOSIS USING AS MODEL A
HIGHLY UNSTABLE TRANSTHYRETIN MUTANT. ESTEFANIA PEREIRA CARDOSO
AZEVEDO, FERNANDO PALHANO, MORGANA SOBRINHO, LUCIANA ROMÃO,
FLÁVIA LIMA, VIVALDO MOURA NETO, DÉBORA FOGUEL
C - 76
SRC KINASE RELAYS INFLAMMATORY INFORMATION TO EXERT A
FINE-TUNED CONTROL OF MICROGLIA ACTIVATION. RENATO SOCODATO,
CAMILA CABRAL PORTUGAL, VIVIAN COREIXAS, ERICK CORREIA LOIOLA, FILIPA
DOMINGUES, ANA RAQUEL SANTIAGO, ROBERTO PAES DE CARVALHO, JOÃO B
RELVAS, FRANCISCO AMBRÓSIO
C - 77
LIPID-LADEN
MULTILOCULAR
CELLS:
DISTRIBUTION,
MORPHOLOGICAL AND PHENOTYPICAL CHARACTERIZATION OF A NEGLECTED
CELL COMPONENT IN THE THYMIC MICROENVIRONMENT OF AGING MICE.
LARISSA GUTMAN PARANHOS LANGHI, LEONARDO RODRIGUES DE ANDRADE,
RADOVAN BOROJEVIC, VALÉRIA DE MELLO COELHO
C - 78
SODIUM
VITAMIN
C
CO-TRANSPORTER-2
(SVCT-2)
INTERNALIZATION UNDER PRO-INFLAMMATORY CONDITIONS IS ASSOCIATED
WITH MICROGLIA ACTIVATION. CAMILA CABRAL PORTUGAL, RENATO SOCODATO,
VIVIAN COREIXAS, ERICK CORREIA LOIOLA, ANA RAQUEL SANTIAGO, ROBERTO
PAES DE CARVALHO, FRANCISCO AMBRÓSIO
C - 79
OBATOCLAX DECREASES NEUTROPHILS IN THE MODEL OF
ANTIGEN-INDUCED ARTHRITIS (AIA) IN MICE. WILLIAM ANTÔNIO GONÇALVES,
FERNANDO LOPES, MAURO MARTINS TEIXEIRA, VANESSA PINHO
C - 80
EXPRESSION OF PLIN2 AND FORMATION OF LIPID BODIES
INDUCED BY DISTINCT SPECIES OF BOTHROPS SNAKE VENOM IN LEUKOCYTES.
NEIDE GALVÃO DO NASCIMENTO, ELBIO LEIGUEZ, KARINA CRISTINA GIANNOTTI,
MARIANA VIANA, CATARINA TEIXEIRA
C - 81
LITHOTHAMNION MUELLERI: A RED ALGAE WHICH REDUCES THE
INFLAMMATORY RESPONSE ASSOCIATED WITH GRAFT-VERSUS-HOST DISEASE
WITHOUT IMPAIR THE BENEFICIAL RESPONSE OF GRAFT-VERSUS-LEUKEMIA.
BARBARA M. REZENDE, PRISCILA T. T. BERNARDES, CAROLINA B. RESENDE, LÍVIA
BARROSO, ROSA M. E. ARANTES, DANIELLE G. SOUZA, MAURO M. TEIXEIRA,
MARINA G. M. CASTOR, VANESSA PINHO
C - 82
BAP1 METALLOPROTEINASE STIMULATES B TYPE SYNOVIOCYTES
TO PRODUCE PGE2 AND REQUIRES COX-2 AND EP4 RECEPTORS TO THIS EFFECT.
MARIANA DO NASCIMENTO VIANA, CRISTINA MARIA FERNANDES, ELBIO LEIGUEZ
JUNIOR, MÁRCIO HIDEKI MATSUBARA, JOSE MARIA GUTIÉRREZ, CATARINA DE
FÁTIMA PEREIRA TEIXEIRA
C - 83
HIGHER ACTIVATED POPULATION OF T LYMPHOCYTES AND
DECREASED T REGULATORY CELL POPULATION IN DMD PATIENTS. LUCIANA
RODRIGUES CARVALHO BARROS, FERNANDA PINTO MARIZ, MARIANA FERREIRA
VEGAS, ALEXANDRA QUEIROZ PRUFER ARAUJO, MARCIA RIBEIRO, MARIA DO
CARMO SOARES CUNHA, WILSON SAVINO
C - 84
ANTI-INFLAMMATORY EFFECTS OF MAYTENUS ILICIFOLIA MART.
EX REISSEK IN SWISS MICE. JANAÍNA VIEIRA BELUSSO, FABÍOLA REGINA BREDA,
CARLA GIANE LOSS, ARNO ERNESTO HOFMANN JUNIOR, SILVANE SOUZA ROMAN
C - 85
ROLE OF CHEMOKINE RECEPTOR CCR4 AND REGULATORY T CELLS
IN WOUND HEALING IN MICE. JANAINA DE BARROS FIGUEIREDO, PAULA
ALVARENGA BORGES, ARIANE RENNÓ BROGLIATO, JANAINA LIMA GEORGII,
CYNTIA PECLI E SILVA, STEVEN L. KUNKEL, CLAUDIA FARIAS BENJAMIM
C - 86
INVOLVEMENT OF IMMUNE RESPONSE IN THE RENAL INJURY
INDUCED BY SEVERE SEPSIS IN MICE. AMANDA REGINA DA FÉ, LEANDRO
LADISLAU ALVES, CYNTIA PECLI E SILVA, RAFAEL DE FREITAS GUILHERME, STEVEN
L. KUNKEL, CLAUDIA FARIAS BENJAMIM, IOLANDA MARGHERITA FIERRO
C - 87
WOUND-HEALING ASSESSMENT OF RUTA GRAVEOLENS L.
(ARRUDA) EXTRACT IN WISTAR RAT SKIN. JANAÍNA VIEIRA BELUSSO, LUANA
RORIG GALLI, CAMILA ZANELLA, GABRIELA GIORDANA LORENZON ALVES,
ROGÉRIO LUIS CANSIAN, SILVANE SOUZA ROMAN
C - 88
PULMONARY FUNCTION, OXIDATIVE STRESS AND INFLAMMATORY
MARKERS IN LPS-INDUCED ACUTE LUNG INJURY: DIFFERENTIAL EFFECTS OF
ATORVASTATIN, PRAVASTATIN AND SIMVASTATIN. ADRIANA CORREA MELO,
LARISSA A. SILVA NETO, JACKSON N. ALVES, MARINA V. BARROSO, DENISE M.
CARDOSO, ALAN A. LOPES, RÔMULO PINTO, RENATA T. NESI, EDUARDO TAVARES
L. TRAJANO, GIOVANNA M. CARVALHO, WALTER ARAÚJO ZIN, LUIS CRISTÓVÃO
PORTO, SAMUEL SANTOS VALENCA
C - 89
THE ANTI-INFLAMMATORY ROLE OF ANNEXIN A1 PROTEIN IN
HUMAN RETINAL PIGMENT EPITHELIUM (ARPE-19) AFTER ENDOTOXEMIA.
KALLYNE KIOKO MIMURA, CRISTIANE DAMAS GIL, SONIA MARIA OLIANI
C - 90
IMPAIRMENT HEALING OF DIABETIC WOUNDS IS IMPROVED BY
ORAL ADMINISTRATION OF ANTIOXIDANTS. ANA FLÁVIA MARÇAL PESSOA,
JULIANA DA COSTA FLORIM, HOSANA G RODRIGUES, MARCELO L LAMERS, RUI
CURI, MARINILCE FAGUNDES DOS SANTOS
C - 91
CELL-CELL INTERACTIONS BETWEEN CHONDROCYTES AND
SYNOVIOCYTES LIKE CELLS. SAMYLLA MIRANDA MONTE, CAMILA BASILE
CARBALLO
C - 92
CELLULAR AND MOLECULAR MECHANISMS OF ANTIINFLAMMATORY EFFECT OF THE SIARESINOLIC ACID. ALMAIR FERREIRA DE
ARAÚJO, JAMYLLE NUNES DE SOUZA FERRO, ANDERSON MARQUES DE OLIVEIRA,
LÚCIA MARIA CONSERVA, EMILIANO DE OLIVEIRA BARRETO
C - 93
ANALYSIS OF RETINOBLASTOMA PHOSPHORYLATION AND
NUCLEAR Β-CATENIN ACCUMULATION HELPS THE DIFFERENTIAL DIAGNOSIS
BETWEEN CROHN’S DISEASE AND ULCERATIVE COLITIS. ROSSANA COLLA SOLETTI,
NATHASSYA ACCIOLY LINS VIDAL RODRIGUES, DEBORAH BIASOLI, VIVALDO
MOURA NETO, HEITOR SIFFERT PEREIRA DE SOUZA, HELENA LOBO BORGES
C - 94
PRO-INFLAMMATORY EFFECTS OF THE P2X7 RECEPTOR IN SEPSIS.
PATRICIA TEIXEIRA SANTANA, LUIZ EDUARDO BAGGIO SÁVIO, CLÁUDIA FARIA
BENJAMIM, CHRISTINA MAEDA TAKIYA, ROBSON COUTINHO SILVA
C - 95
INHIBITORY EFFECT OF CURINE ON EOSINOPHIL ACTIVATION AND
AIRWAY HYPER-RESPONSIVENESS. JAIME RIBEIRO FILHO, ADRIANA VIEIRA-DEABREU, ANDREA SURRAGE CALHEIROS, JULIANA ALVES AZEREDO, CELIDARQUE DA
SILVA DIAS, MÁRCIA REGINA PIUVEZAM, PATRÍCIA TORRES BOZZA
C - 96
STEM CELL FACTOR INDUCES PIECEMEAL DEGRANULATION IN
HUMAN EOSINOPHIL. KENNEDY BONJOUR DE OLIVEIRA FERREIRA, FELIPE FERRAZ
DIAS, ANN M. DVORAK, PETER F. WELLER, ROSSANA CORREA NETTO MELO
C - 97
INVOLVEMENT OF PPARGAMMA ON LIPID BODY FORMATION
AND HOST IMMUNE RESPONSE DURING INFECTION BY TRYPANOSOMA CRUZI.
LÍVIA TEIXEIRA, HELOÍSA D'ÁVILA, CÉLIO GERALDO FREIRE DE LIMA, ROSSANA
CORREA NETTO DE MELO, PATRÍCIA TORRES BOZZA
C - 98
IMPACT OF THE ABSENCE OF GALECTIN-3 ON THE COURSE OF
EXPERIMENTAL INFECTION WITH TRYPANOSOMA CRUZI. DANIELLE SILVA DOS
SANTOS, JULIANA BARRETO DE ALBUQUERQUE, LUIZ RICARDO BERBERT, LANDI
V.C. GUILLERMO, WILSON SAVINO, JULIANA DE MEIS, DÉA M. S. VILLA-VERDE
C - 99
HEMATOLOGICAL PARAMETERS OF CHICKENS TREATED WITH
NITRIC OXIDE INHIBITOR AND INFECTED WITH PLASMODIUM GALLINACEUM.
BARBARELLA DE MATOS MACCHI, FARLEN JOSÉ BEBBER MIRANDA, FERNANDA
SILVA DE SOUZA, EULÓGIO CARLOS QUEIROZ DE CARVALHO, ANTÔNIO PEIXOTO
ALBERNAZ, JOSÉ LUIZ MARTINS DO NASCIMENTO, RENATO AUGUSTO DAMATTA
C - 100
NEUROPROTECTIVE EFFECTS OF MELATONIN SYNTHESIZED BY
CEREBELLAR GRANULE CELLS CULTURES. DAIANE GIL FRANCO, ADRIESSA
APARECIDA DOS SANTOS, REGINA P. MARKUS
C - 101
ANTIOXIDANT AND CHEMICAL PROFILE OF BRAZILIAN PROPOLIS:
AN IN VITRO STUDY. ALAN DE AGUIAR LOPES, LARISSA ALEXSANDRA SILVA-NETO,
THIAGO DOS SANTOS FERREIRA, KARLA MARIA PEREIRA PIRES, MANUELLA
LANZETTI, RENATA TISCOSKI NESI, ARI MIRANDA SILVA, ANTONIO JORGE RIBEIRO
DA SILVA, SAMUEL DOS SANTOS VALENÇA, LUÍS CRISTÓVÃO DE MORAES SOBRINO
PÔRTO
C - 102
BLOCKAGE OF EXTRACELLULAR ATP/ADP SIGNALING REDUCES
ACETAMINOPHEN-INDUCED LIVER DAMAGE. JAYANE LAIS DIAS QUINTÃO, SYLVIA
STELLA AMARAL, PEDRO ELIAS MARQUES, DANIELE ARAÚJO PIRES, GUSTAVO
BATISTA MENEZES
C - 103
CARDIAC
HYPERTROPHY
INDUCED
RENAL
ISCHEMIA/REPERFUSION: GENE EXPRESSION ANALYSIS OF INFLAMMATORY
CELLS PROLIFERATION IN HEART TISSUE. KARINA KAORI NAKAMA, MARCELA
SORELLI CARNEIRO RAMOS
C - 104
A SNAKE VENOM SECRETED PHOSPHOLIPASE A2 INDUCES PPAR-Γ
AND –Β EXPRESSION AND ACTIVATION IN MACROPHAGES: IMPLICATION IN
PLIN2 PROTEIN EXPRESSION. ELBIO LEIGUEZ, KARINA CRISTINA GIANNOTTI, JOSÉ
MARIA GUTIÉRREZ, BRUNO LOMONTE, CATARINA TEIXEIRA
C - 105
AMYLOID-BETA PEPTIDE TRIGGERS NUCLEAR FACTOR KAPPA B
SIGNALING PATHWAY IN RAT PINEAL GLANDS. ERIKA CECON, PEDRO AUGUSTO
CARLOS MAGNO FERNANDES, EDUARDO KOJI TAMURA, REGINA PEKELMANN
MARKUS
C - 106
EVALUATION OF THE EFFECT OF PROPIONIBACTERIUM ACNES ON
THE SURVIVAL OF ANIMALS WITH LETHAL SEPSIS. SAMARA KELLY MENDONÇA DE
OLIVEIRA, JOSÉ BRUNO NUNES FERREIRA DA SILVA, LARISSA CARDOSO CORRÊA DE
ARAÚJO, JACIANA DOS SANTOS AGUIAR, TERESINHA GONÇALVES DA SILVA
C - 107
MECHANISMS INVOLVED IN LIPID BODY FORMATION AND
AUTOPHAGY DURING EXPERIMENTAL INFECTION BY MYCOBACTERIUM BOVIS
BCG IN MICE. HELOISA D`AVILA DA SILVA BIZARRO, NATÁLIA ROBERTA ROQUE,
ALINE APARECIDA ASSIS, DOUGLAS MOREIRA DE ARAÚJO, GABRIEL SANTOS CRUZ
RODRIGUES, SÍLVIA LUCENA LAGE, PATRÍCIA ELAINE ALMEIDA, ROSSANA. CORREA
NETTO MELO, HUGO C. CASTRO-FARIA-NETO, CLARISSA MAYA MONTEIRO,
PATRÍCIA TORRES BOZZA
100
C - 108
ROLE OF CAVEOLIN-1 IN THE REGULATION OF PRODUCTION OF
INFLAMMATORY MEDIATORS IN PERITONEAL MACROPHAGES.CECÍLIA JACQUES
GONÇALVES DE ALMEIDA, CAROLINA DA PAZ ZAMPIER, MICHAEL P. LISANTI,
PATRÍCIA T. BOZZA
D-5
TESTES MORPHOLOGY AND SPERMATOGENESIS IN TELCHIN LICUS
LICUS (LEPIDOPTERA: CASTNIIDAE) MONIQUE CAMPOS PEREIRA, DANIELA
CARVALHO DOS SANTOS, ELTON LUIZ SCUDELER, ANA SILVIA GIMENES GARCIA,
REINALDO JOSÉ DA SILVA
C - 109
EARLY AND LATE ACUTE LUNG INJURY AND ITS ASSOCIATION
WITH DISTAL ORGAN DAMAGE IN EXPERIMENTAL MALARIA. MARIANA
CONCEIÇÃO DE SOUZA, JOHNATAS DUTRA SILVA, TATIANA ALMEIDA PADUA, VERA
LUIZA CAPELOZZI, PATRICIA R. M. ROCCO, MARIA DAS GRAÇAS HENRIQUES
D-6
REPRODUCTIVE DEVELOPMENT OF THE MALE OFFSPRING FROM
RATS TREATED WITH CARBAMAZEPINE DURING PREGNANCY SAMARA URBAN DE
OLIVA, TAIZA STUMPP, SANDRA MARIA MIRAGLIA
C - 110
SNAKE VENOM TOXIN BMOOMP-ALFA-I INHIBITS ANGIOGENESIS
IN MURINE MODELS. SAULO ANTONIO GOMES FILHO, PUEBLA CASSINI VIEIRA,
SIMONE RAMOS DECONTE, AMANDA VIEIRA, FABIO DE OLIVEIRA, FERNANDA DE
ASSIS ARAÚJO
C - 111
NO AND IL-1Β PRODUCTION BY MURINE MACROPHAGES TREATED
WITH LECTINS CMOL AND WSMOL. LARISSA CARDOSO CORRÊA DE ARAÚJO,
JACIANA DOS SANTOS AGUIAR, MARIA DO DESTERRO RODRIGUES, JEYCE KELLE
FERREIRA DE ANDRADE, LUANA CASSANDRA BREITENBACH BARROSO COELHO,
TERESINHA GONÇALVES DA SILVA, PATRÍCIA MARIA GUEDES PAIVA
C - 112
DOWN-MODULATION OF ACTIVATED HUMAN NEUTROPHIL BY
LMW-FUCOIDAN. JOÃO ALFREDO DE MORAES, ANA CLARA FRONY, GENILSON
RODRIGUES, CATHERINE BOISSON-VIDAL, CHRISTINA BARJA-FIDALGO
C - 113
DIESEL PARTICLES (DEP) INDUCE MELATONIN SYNTHESIS BY
MACROPHAGES THROUGH NF-KB ACTIVATION. CLAUDIA EMANUELE CARVALHO
DE SOUSA, SANDRA MARCIA MUXEL, ALESSANDRA STRANIERI, MARIANGELA
MACCHIONE, PAULO HILARIO NASCIMENTO SALDIVA, REGINA PEKELMANN
MARKUS
C - 114
CHARACTERIZATION OF GENE EXPRESSION IN CD14+CD16-,
CD14+CD16+ AND CD14DIMCD16++ MONOCYTE SUBSETS IN OBESITY. MARIANA
RENOVATO MARTINS, ESTELLE DEVEVRE, ELISE DALMAS, JEAN-LUC BOUILLOT,
ARNAUD BASEDEVANT, WOLF-HERMAN FRIDMAN, THEREZA CHRISTINA BARJAFIDALGO, KARINE CLÉMENT, CATHERINE SAUTÈS-FRIDMAN, ISABELLE CREMER,
CHRISTINE POITOU
C - 115
EVALUATION OF THE EFFECT OF 5 AZA CYTIDINE ON THE WOUND
HEALING IN WISTAR RATS. FABIANA DE SOUZA GOMES, LÍCIO AUGUSTO VELLOSO,
CARLA EVELYN COIMBRA NUÑEZ, GABRIELA FREITAS PEREIRA DE SOUZA, MARIA
HELENA MELO LIMA, RAFAEL DE MORAES PEDRO, ELIANA PEREIRA DE ARAÚJO
C - 116
THE ROLE OF PURINERGIC P2X7 RECEPTORS IN MURINE SILICOSIS.
LEONARDO MONÇÃO RIBEIRO, PATRICIA TEIXEIRA SANTANA, RADOVAN
BOROJEVIC, CHRISTINA MAEDA TAKIYA, ROBSON COUTINHO SILVA
C - 117
INCREASED LEPTIN RESPONSE AND INHIBITION OF APOPTOSIS IN
THYMIC CELLS FROM YOUNG OFFSPRING SUBMITTED TO MATERNAL PROTEIN
DEPRIVATION DURING LACTATION. SIMONE VARGAS DA SILVA, CAROLINA
SALAMA, MARIANA RENOVATO MARTINS, EDWARD HELAL NETO, MARTA CITELLI,
WILSON SAVINO, CHRISTINA BARJA-FIDALGO
C - 118
SHORT- TERM TREATMENT WITH IL-10-PRODUCING LACTOCOCCUS
LACTIS REDUCES SYSTEMIC IL-17 BUT DO NOT IMPROVE THE CLINICAL SIGNALS
OF COLITIS.LUÍSA LEMOS DOS SANTOS, ANA CRISTINA GOMES-SANTOS, THAIS
GARCIA MOREIRA, BERNARDO COELHO HORTA, ANDERSON MIYOSHI, DENISE
CARMONA CARA, ANA MARIA CAETANO DE FARIA
D – Cell Biology and
Reproduction
D1-D140
D-1
STRUCTURAL AND ULTRASTRUCTURAL ANALYSIS OF THE
PLACENTA IN PREGNANT RATS FED WITH PROTEIN RESTRICTION DIET. HÉRCULES
JONAS REBELATO, MARCELO AUGUSTO MARRETTO ESQUISATTO, PAULO PINTO
JOAZEIRO, ROSANA CATISTI
D-2
HYPERTHERMIC STRESS AFFECTS SPERMATOGENESIS EUPEMPHIX
NATTERERI (ANURA: LEIUPERIDAE) GABRIELA BARONI LEITE, JULIANE
SILBERSCHIMDIT FREITAS, LIA RAQUEL SOUZA DOS SANTOS, LILIAN FRANCOBELUSSI, CLASSIUS DE OLIVEIRA
D-3
CHRONIC CAFFEINE INTAKE INCREASES ANDROGENIC STIMULI,
EPITHELIAL CELL PROLIFERATION AND HYPERPLASIA IN RAT VENTRAL PROSTATE
SÉRGIO LUIS FELISBINO, CAROLINA SAROBO, LIVIA MARIA LACORTE, MARCELA
MARTINS, JAQUELINE CARVALHO RINALDI, IVAN JOSÉ VERCHETTI JUNIOR, ANDREI
MOROZ, WELLERSON RODRIGO SCARANO, FLAVIA KARINA DELELLA
D-4
SPERMATOGENESIS IN EUPEMPHIX NATTERERI (ANURA:
LEIUPERIDAE): LATE RESPONSE TO LPS LARA SALGUEIRO DE GREGORIO, LILIAN
FRANCO-BELUSSI, GABRIELA BARONI LEITE, JULIANE SILBERSCHMIDT FREITAS,
CLASSIUS DE OLIVEIRA
D-7
EVALUATION OF THE EFFECTS OF ABLATION OF TESTOSTERONE IN
PROSTATIC
COMPLEX
OF
ARTIBEUS
PLANIROSTRIS
(CHIROPTERA:
PHYLLOSTOMIDAE). CINTIA CRISTINA ISICAWA PUGA, MATEUS RODRIGUES
BEGUELINI, FABIANE FERREIRA MARTINS, ELIANA MORIELLE VERSUTE, PATRICIA
SIMONE LEITE VILAMAIOR, SEBASTIÃO ROBERTO TABOGA
D-8
EFFECT OF CARNITINE AND OF ETOPOSIDE ON SPERMATOGONIAL
STEM/PROGENITOR CELLS OF RATS TREATED IN THE PREPUBERTAL PHASE.
FATIMA KAZUE OKADA, TAIZA STUMPP, SANDRA MARIA MIRAGLIA
D-9
COMPARATIVE STUDY OF BATS IN DORSAL PROSTATE
REPRESENTATIVES OF THE SUBFAMILIES: GLOSSOPHAGINAE, CAROLLINAE E
PHYLLOSTOMINAE (CHIROPTERA-PHYLLOSTOMIDAE)
FABIANE FERREIRA
MARTINS, CINTIA ISICAWA PUGA, MATEUS RODRIGUES BEGUELINI, PATRICIA
SIMONE LEITE VILAMAIOR, ELIANA MORIELLE-VERSUTE, SEBASTIÃO ROBERTO
TABOGA
D - 10
INVOLVEMENT OF ABCB1 AND ABCC1 PROTEINS IN SEA URCHIN
FERTILIZATION PROCESS. HELENA LIMA DA SILVA NETA, TALITTA DANTAS DE
ARRUDA, ELIS TORREZAN GONÇALVES RAMALHO NITÃO, LUIS FERNANDO
MARQUES-SANTOS
D - 11
GERM CELLS RECOVERY IN IRRADIATED RAT TESTIS AFTER
TREATMENT WITH ACYLINE - A GNRH ANTAGONIST - AND FLUTAMIDE – AN
ANDROGEN
RECEPTOR
ANTAGONIST
AMANDA
VASCONCELOS
DE
ALBUQUERQUE, MARVIN L. MEISTRICH, GUNAPALA SHETTY, FERNANDA F.R.C.L.
ALMEIDA, HÉLIO CHIARINI GARCIA
D - 12
CHARACTERIZATION OF INTERCELLULAR JUNCTIONS IN
FIBROBLASTS OF MOUSE PUBIC SYMPHYSIS DURING PREGNANCY AND
POSTPARTUM VIVIANE DE SOUZA ROSA, SÍLVIO ROBERTO CONSONNI, MONICA
MOREIRA, BIANCA CASTELUCCI, PAULO PINTO JOAZEIRO
D - 13
CHANGES OF THE MOUSE INTERPUBIC TISSUE THROUGHOUT THE
MIDST OF PREGNANCY GABRIELA TOGNINI SABA, GIULLIANA PETRI, JULIANA
MORA VERIDIANO, OLGA MARIA DE TOLEDO CORREA
D - 14
MORPHOMETRICAL, STEREOLOGICAL AND ULTRASTRUCTURAL
STUDY OF GREEN PROPOLIS EFFECTS ON RAT EPIDIDYMIS CRISTINA CAPUCHO,
FABRÍCIA DE SOUZA PREDES, JULIANA DE CASTRO MONTEIRO, RENATA BARBIERI,
MARY ANNE HEIDI DOLDER, GRASIELA DIAS DE CAMPOS SEVERI-AGUIAR
D - 15
EXTENSIVE MONONUCLEAR INFILTRATION AND POSTPARTUM
MOUSE PUBIC SYMPHYSIS RECOVERY BIANCA GAZIERI CASTELUCCI, SÍLVIO
ROBERTO CONSONNI, VIVIANE DE SOUZA ROSA, PAULO PINTO JOAZEIRO
D - 16
HETEROCHROMATIN PATTERNS IN TRIATOMA WILLIAMI
(HEMIPTERA, TRIATOMINAE) NATHÁLIA PAIVA PERERIA, PRISCILA PASQÜETTO
MENDONÇA, KAIO CESAR CHABOLI ALEVI, ANNA CLAUDIA CAMPANER LIMA, JOÃO
ARISTEU DA ROSA, MARIA TERCÍLIA VILELA DE AZEREDO OLIVEIRA
D - 17
LONG-TERM EFFECTS OF DEVELOPMENTAL EXPOSURE TO
BISPHENOL A (BPA) ON THE PROSTATE OF ADULT RATS: CHEMOPROTECTIVE
EFFECT OF INDOLE-3-CARBINOL (I3C) JOYCE ZALOTTI BRANDT, LÍVIA TERESA
RIBEIRO DA SILVEIRA, TONY FERNANDO GRASSI, WAGNER JOSÉ FÁVARO, RAQUEL
FANTIN DOMENICONI, JANETE A. ANSELMO-FRANCI, JOSÉ EDUARDO BOZANO,
LUIS FERNANDO BARBISAN, WELLERSON RODRIGO SCARANO
D - 18
C-HETEROCHROMATIN PATTERN AND NUCLEOLAR ACTIVITY IN
HOLOCENTRIC CHROMOSOMES OF TRIATOMA LENTI (HEMIPTERA: REDUVIIDAE)
KAIO CESAR CHABOLI ALEVI, PRISCILA PASQÜETTO MENDONÇA, NATHÁLIA PAIVA
PEREIRA, ANNA CLAUDIA CAMPANER LIMA, JOÃO ARISTEU DA ROSA, MARIA
TERCÍLIA VILELA DE AZEREDO OLIVEIRA
D - 19
COMPARATIVE CYTOGENETIC STUDY BETWEEN TRIATOMA
VANDAE E TRIATOMA WILLIAMI (HEMIPTERA, TRIATOMINAE) NATHÁLIA PAIVA
PERERIA, PRISCILA PASQÜETTO MENDONÇA, KAIO CESAR CHABOLI ALEVI, ANNA
CLAUDIA CAMPANER LIMA, JOÃO ARISTEU DA ROSA, MARIA TERCÍLIA VILELA DE
AZEREDO OLIVEIRA
D - 20
NUCLEOLAR ACTIVITY IN SPERMATOGENESIS OF RHODNIUS
BRETHESI (HEMIPTERA, TRIATOMINAE) PRISCILA PASQÜETTO MENDONÇA, KAIO
CESAR CHABOLI ALEVI, NATHÁLIA PAIVA PEREIRA, ANNA CLAUDIA CAMPANER
LIMA, JOÃO ARISTEU DA ROSA, MARIA TERCÍLIA VILELA DE AZEREDO OLIVEIRA
D - 21
STUDY OF SPERMATOGENESIS OF TRIATOMA SHERLOCKI
(HEMIPTERA, TRIATOMINAE) ANNA CLAUDIA CAMPANER LIMA, KAIO CESAR
CHABOLI ALEVI, PRISCILA PASQÜETTO MENDONÇA, NATHÁLIA PAIVA PEREIRA,
JOÃO ARISTEU DA ROSA, MARIA TERCÍLIA VILELA DE AZEREDO OLIVEIRA
D - 22
NUCLEOLAR CYCLE IN TRIATOMA WILLIAMI (HEMIPTERA,
TRIATOMINAE) NATHÁLIA PAIVA PEREIRA, PRISCILA PASQÜETTO MENDONÇA,
KAIO CESAR CHABOLI ALEVI, ANNA CLAUDIA CAMPANER LIMA, JOÃO ARISTEU DA
ROSA, MARIA TERCÍLIA VILELA DE AZEREDO OLIVEIRA
101
D - 23
QUANTITATIVE EVALUATION AND SPATIAL LOCALIZATION OF
SPONTANEOUS AND MNU-INDUCED PROSTATE TUMORS IN GERBILS BIANCA
FACCHIM GONÇALVES, SILVANA GISELE PEGORIN DE CAMPOS, CAMILA HELENA
FACINA, LUIZ ROBERTO FALLEIROS JR, SEBASTIÃO ROBERTO TABOGA
D - 24
MELATONIN: MITIGATING DAMAGES IN STREPTOZOTOCINDIABETIC RAT TESTIS CAROLINA FRANDSEN PEREIRA DA COSTA, MARINA
GUIMARÃES GOBBO, MARIA ETELVINA PINTO, EDUARDO ALVES DE ALMEIDA,
REJANE MAIRA GÓES
D - 25
SERTOLI CELL INDEX IN THE FRUGIVOROUS BAT STURNIRA LILIUM
DANIELLE BARBOSA MORAIS, SÉRGIO LUIS PINTO DA MATTA
D - 26
SPERMATIC RESERVE IN THE TESTIS OF THE INSECTIVOROUS BAT
MOLOSSUS MOLOSSUS DANIELLE BARBOSA MORAIS, SÉRGIO LUIS PINTO DA
MATTA
D - 27
EFFECTS OF THE INSECTICIDE ENDOSULFAN ON LEYDIG CELLS OF
THE BIG FRUIT-EATING BAT ARTIBEUS LITURATUS (OLFERS,1818) DANIELLE
BARBOSA MORAIS, ALESSANDRO BRINATI, SÉRGIO LUIS PINTO DA MATTA,
MARIELLA BONTEMPO DUCA DE FREITAS, JULIANA SILVA ROCHA, SENDY MOREIRA
REIS, JULIANA MATTOS SOUZA LIMA, MICHELE OLIVEIRA SANTOS
D - 28
LONG-TERM SERTOLI CELL RESISTANCE IN TESTIS OF ADULT
WISTAR RATS EXPOSED TO A SINGLE CADMIUM IP INJECTION. RODRIGO PAULA
LEITE, MARY ANNE HEIDI DOLDER
D - 29
ENVIRONMENTALLY REALISTIC HIGH DOSE OF CADMIUM
INCREASES LIPID PEROXIDATION IN WISTAR RAT TESTIS: IS THE
HEMATOTESTICULAR BARRIER A MAJOR TARGET OF FREE RADICALS? MARY
ANNE HEIDI DOLDER, MARY ANNE HEIDI DOLDER, FERNANDA RAMOS GADELHA,
LUÍS HENRIQUE GONZAGA RIBEIRO
D - 30
TIME-DEPENDENT EFFECTS OF CADMIUM ON BLOOD VESSEL
ENDOTHELIUM - HISTOPATHOLOGICAL AND STEREOLOGICAL ANALYSIS.
RODRIGO PAULA LEITE, FERNANDA RAMOS GADELHA, MARY ANNE HEIDI DOLDER
D - 41
GESTATIONAL EXPOSURE OF GERBILS TO ETHINYLESTRADIOL
REDUCES THE NUMBER OF GONOCYTES AT BIRTH. MARIANA PULEGIO, ANA
PAULA DA SILVA PEREZ, MARIA ETELVINA PINTO, REJANE MAIRA GÓES
D - 42
MORPHOLOGICAL CHANGES IN THE PLACENTA OF ALLOXAN
INDUCED DIABETIC RATS PRISCILLA SILVA FARIAS, KARINE DOS SANTOS SOUZA,
ANDERSON CARLOS MARCAL, MARCIO ROBERTO VIANA DOS SANTOS, EMERSON
TICONA FIORETTO, MARLÚCIA BASTOS AIRES
D - 43
RELATION BETWEEN SPERM LENGTH AND SIZE OF THE INDIVIDUAL
WHO PRODUCES GLENDA DIAS, HELEN PINTO SANTOS, JOSÉ LINO-NETO
D - 44
GERM CELLS DEVELOPMENT IN THE DOURADO SALMINUS
FRANCISCANUS LIMA & BRITSKI, 2007 FROM THE SÃO FRANCISCO RIVER BASIN:
A HISTOLOGICAL AND ULTRASTRUCTURAL STUDY LEONARDO JOSÉ ALVES DE
FREITAS, PAULA SUZANNA PRADO, KLEBER B. SANTIAGO, MARCOS VINICIUS TELES
GOMES, NILO BAZZOLI, ELIZETE RIZZO
D - 45
BISPHENOL A (BPA) AND INDOLE-3-CARBINOL (I3C): EFFECTS ON
THE MALE RATS PROSTATE DEVELOPMENT LÍVIA TERESA RIBEIRO DA SILVEIRA,
JOYCE ZALOTTI BRANDT, TONY FERNANDO GRASSI, WAGNER JOSÉ FAVARO,
RAQUEL FANTIN DOMENICONI, PATRÍCIA FERNANDA FELIPE PINHEIRO, LUIS
FERNANDO BARBISAN, WELLERSON RODRIGO SCARANO
D - 46
REPRODUCTION AND SPAWNING OF DOURADO SALMINUS
FRANCISCANUS LIMA & BRITSKI, 2007 IN THE SÃO FRANCISCO RIVER, TRÊS
MARIAS, MINAS GERAIS, BRAZIL LEONARDO JOSÉ ALVES DE FREITAS, PAULA
SUZANNA PRADO, KLEBER B. SANTIAGO, MARCOS VINICIUS TELES GOMES, NILO
BAZZOLI, ELIZETE RIZZO
D - 47
EXPRESSION OF THE ESTROGEN RECEPTOR ERBETA IN THE
VENTRAL AND DORSAL PROSTATE OF AGING RATS MÔNICA MORAIS SANTOS,
RACHEL PIRES REIS, AMANDA CRISTINA REIS GONZAGA, ANDRÉ GUSTAVO
OLIVEIRA, GERMÁN ARTURO BOHORQUEZ MAHECHA, MARIA CHRISTINA AVELLAR,
CLEIDA APARECIDA DE OLIVEIRA
D - 31
SPERMATOGENIC EFFICIENCY OF WILD RODENT OLIGORYZOMYS
NIGRIPES (RODENTIA, MURIDAE) MAYTÊ KOCH BALARINI, ANA CAROLINA TORRE
MORAIS, TATIANA PRATA DE MENEZES, DANIELLE BARBOSA MORAIS, MICHELE
OLIVEIRA SANTOS, FAUSTO FERRAZ, SÉRGIO LUIS PINTO DA MATTA
D - 48
EFFECTS OF THE HERBICIDE ATRAZINE IN THE EXPRESSION OF
P450-AROMATASE IN THE TESTIS, EPIDIDYMIS AND PROSTATE OF ADULT MALE
RATS ELISÂNGELA MARTINS DOS SANTOS, CRISTIANO GUIMARÃES PIMENTA,
POLLYANA RABELO NUNES CAMPOS, GERMÁN ARTURO BOHORQUEZ MAHECHA,
CLEIDA APARECIDA OLIVEIRA
D - 32
COMPARATIVE STUDY OF APOPTOTIC PROFILE ACTIVATED BY
INTRINSIC AND EXTRINSIC PATHWAYS IN VENTRAL PROSTATE OF AGING RATS
AMANDA CRISTINA REIS GONZAGA, MÔNICA MORAIS SANTOS, JÚNIA DAYRELL DE
MOURA CORDEIRO, GERMÁN ARTURO BOHÓRQUEZ MAHECHA, CLEIDA
APARECIDA OLIVEIRA
D - 49
REPRODUCTIVE AND HISTOLOGICAL PARAMETERS OF ADULT RATS
EXPOSED TO SIBUTRAMINE GABRIELA MISSASSI, CIBELE DOS SANTOS BORGES,
RAQUEL FRENEDOSO DA SILVA, JULIANA ELAINE PEROBELLI, MARCIANA
SANABRIA, THAIS PETROCHELLI BANZATO, MARIANA MACÊDO DE OLIVEIRA,
WILMA DE GRAVA KEMPINAS
D - 33
ACTIONS OF AÇAÍ PULP (EUTERPE EDULLIS) ON THE EPIDIDYMAL
CAPUT REGION HISTOMORPHOMETRY OF WISTAR RATS EXPOSED TO CADMIUM
CHLORIDE (CDCL2) ANA CLÁUDIA FERREIRA SOUZA, GRAZIELA DOMINGUES DE
ALMEIDA LIMA, TATIANA PRATA MENEZES, MARLI DO CARMO CUPERTINO,
SÉRGIO LUÍS PINTO DA MATTA, MARIANA MACHADO NEVES
D - 50
EVALUATION
OF
REPRODUCTIVE
AND
HISTOLOGICAL
PARAMETERS ON TESTIS AND EPIDIDYMIS OF ADULT MALE RATS EXPOSED TO
SIMVASTATIN. THAIS PETROCHELLI BANZATO, MARIANA MACÊDO OLIVEIRA,
JULIANA ELAINE PEROBELLI, MARCIANA SANABRIA, CIBELE DOS SANTOS BORGES,
RAQUEL FRENEDOSO DA SILVA, GABRIELA MISSASSI, WILMA DE GRAVA KEMPINAS
D - 34
EFFECTS OF AÇAÍ PULP (EUTERPE EDULLIS) ON CADMIUM
CHLORIDE-INDUCED DAMAGE IN EPIDIDYMAL CAPUT REGION OF ADULT RATS: A
MORPHOMETRIC STUDY GRAZIELA DOMINGUES DE ALMEIDA LIMA, TATIANA
PRATA MENEZES, VIVIANE SILVEIRA GORETE MOURO, RAFAEL REIS DOMINGUES,
NAYARA MAGALHÃES GONÇALVES, MARLI DO CARMO CUPERTINO, SÉRGIO LUÍS
PINTO DA MATTA SERGIO, MARIANA MACHADO NEVES
D - 51
NUCLEUS OF PROSTATIC EPITHELIAL CELL OF SENESCENT GERBILS
AS A TARGET ORGANELLE OF STUDY AFTER HORMONE DEPRIVATION SILVANA
GISELE PEGORIN DE CAMPOS, BIANCA FACCHIM GONÇALVES, WELLERSON
RODRIGO SCARANO, LUIZ ROBERTO FALLEIROS JÚNIOR, SEBASTIÃO ROBERTO
TABOGA
D - 35
NO LEVEL AS AN INDICATOR OF SICKNESS BEHAVIOR AND UTERINE
MORPHOPHYSIOLOGICAL CHANGES IN LPS-TREATED PREGNANT MICE BRUNO
ZAVAN, ELIANA MARA OLIVEIRA LIPPE, ALEXANDRE GIUSTI-PAIVA, AUREO
TATSUMI YAMADA, VALDEMAR ANTONIO PAFFARO JUNIOR
D - 36
EFFECTS OF THE MUTATION IN THE FOXN1 GENE IN THE ADULT
MICE TESTIS STRUCTURE AND FUNCTION CAROLINA FELIPE ALVES DE OLIVEIRA,
GLEIDE FERNANDES AVELAR, LUIZ RENATO DE FRANÇA
D - 37
PROTEIN UNDERNUTRITION MODIFIES THE EPITHELIUMMESENCHYME INTERACTION AND DELAYS THE PROSTATE DIFFERENTIATION IN
NEONATAL RATS CRISTIANE FIGUEIREDO PINHO, PATRÍCIA FERNANDA FELIPE
PINHEIRO, RAQUEL FANTIN DOMENICONI, BRUNO CÉSAR SCHIMMING, WAGNER
JOSÉ FAVARO, SÉRGIO PEREIRA, SILVANA GISELE PEGORIN DE CAMPOS,
SEBASTIÃO ROBERTO TABOGA, PATRÍCIA ALINE BOER, WELLERSON RODRIGO
SCARANO
D - 38
STROMAL CHANGES IN THE VENTRAL PROSTATE OF LONG- TERM
OBESE RATS ARE ASSOCIATED TO INCREASED MMP-9 ACTIVITY AND HIGH VEGF
CONTENT SILAS AMÂNCIO SILVA, RENATO SIMÕES CORDEIRO, TATIANA CARLA
TOMIOSSO, SEBASTIÃO ROBERTO TABOGA, REJANE MAIRA GÓES, DANIELE LISBOA
RIBEIRO
D - 52
EXTRAORDINARY DIVERSITY OF SPERM MORPHOLOGY AMONG
MARINE BIVALVES OF THE SUPERFAMILY TELLINOIDEA (MOLLUSCA):
SPERMATOZOA RANGING FROM ECT-AQUASPERM TO THOSE WITH SCREW-LIKE
HEAD, AND UNCOMMON PARASPERMATIC FEATURES GISELE ORLANDI INTROÍNI,
LENITA DE FREITAS TALLARICO, FLÁVIO DIAS PASSOS, SUGURU UJINO, SHIRLEI
MARIA RECCO-PIMENTEL
D - 53
HIGH-FAT DIET ACT AS A PROMOTIONAL AGENT ON PROSTATE
CARCINOGENESIS OF GERBILS. CAMILA HELENA FACINA, BIANCA FACCHIM
GONÇALVES, LUIZ ROBERTO FALLEIROS JR, SEBASTIÃO ROBERTO TABOGA
D - 54
EFFECT OF EXTRACTS FROM THE SEED OF NEEM(AZADIRACHTA
INDICA A JUSS) ON THE MORPHOMETRY SEMINIFEROUS TUBULES OF WISTAR
RATS. FERNANDA CAROLINA RIBEIRO DIAS, ALLUANAN ADELSON NASCIMENTO,
JESSICA SANTANA, OLAVIO CAMPOS JUNIOR, SIMONE CABRAL, WOLFGANG
HARAND, ELIZABETH NEVES DE MELO
D - 55
ADMINISTRATION OF AN ANDROGEN COMPOUND TO FEMALE
WISTAR RATS DURING GESTATIONAL AND LACTATIONAL PERIODS AND THE
ASSESSMENT OF THE EFFECTS ON THE UTERUS OF THE FEMALE OFFSPRING
MARINA TREVIZAN GUERRA, RAQUEL FRENEDOSO DA SILVA, MARCIANA
SANABRIA, GAIL GROSSMAN, PETER PETRUSZ, WILMA DE GRAVA KEMPINAS
D - 39
THE SIZE OF THE SPERM FOLLOWS THE SIZE OF THE INDIVIDUALS
WHO PRODUCE IN CLOSELY RELATED SPECIES? HELEN CRISTINA PINTO SANTOS,
GLENDA DIAS, RAQUEL APARECIDA COSTA, JOSÉ LINO NETO
D - 56
EXPRESSION OF GLYCOCONJUGATES IN THE UTERINE NATURAL
KILLER CELLS FROM GENETICALLY MODIFIED MOUSE. ÉVILA DA SILVA LOPES
SALLES, PAULO FERNANDO DE SOUZA JÚNIOR, ANDRÉA MOLLICA DO AMARANTE
PAFFARO, BARBARA ANNE CROY, AÚREO TATSUMI YAMADA, VALDEMAR
ANTÔNIO PAFFARO JÚNIOR
D - 40
VEGF PROTEIN EXPRESSION IN THE PLACENTA OF ALLOXAN
INDUCED DIABETIC RATS KARINE DOS SANTOS SOUZA, PRISCILLA SILVA FARIAS,
WALDECY DE LUCCA JUNIOR, ANDERSON CARLOS MARCAL, MARCIO ROBERTO
VIANA DOS SANTOS, THIAGO ALVES BRAGA, EMERSON TICONA FIORETTO,
MARLÚCIA BASTOS AIRES
D - 57
OXIDATIVE STRESS IN THE KIDNEY OF FEMALE RATS WITH OR
WITHOUT REPRODUCTIVE ACTIVITY DURING AGING JORDANA SALETE PUTTI,
ANA CAROLINA ALMEIDA DA SILVA, TIAGO BOEIRA SALOMON, CAMILE SAUL
BEHLING
102
D - 58
VITELLOGENIN
AND
ZONA
RADIATA
PROTEINS
IMMUNODETECTION IN LIVER OF LAMBARI ASTYANAX FASCIATUS FROM THE
FURNAS RESERVOIR, GRANDE RIVER, BRAZIL PAULA SUZANNA PRADO, ANA
PAULA BARBOSA PINHEIRO, ELIZETE RIZZO
D - 59
LIVER IGF-I E IGF-II IMMUNOCHEMICAL QUANTIFICATION IN
ASTYANAX FASCIATUS FROM ESTROGEN CONTAMINATED AREAS FROM THE
FURNAS RESERVOIR, GRANDE RIVER, BRAZIL PAULA SUZANNA PRADO, ANA
PAULA BARBOSA PINHEIRO, ELIZETE RIZZO
NOGUEIRA, GERMÁN ARTURO BOHORQUEZ MAHECHA, CLEIDA APARECIDA DE
OLIVEIRA
D - 76
INVESTIGATION OF AQUAPORIN-9 IN THE EFFERENT DUCTULES
AND EPIDIDYMIS OF BIG FRUIT-EATING BAT ARTIBEUS LITURATUS DURING THE
ANNUAL REPRODUCTIVE CYCLE REGIANA LUCIA DE OLIVEIRA, JOSÉ CARLOS
NOGUEIRA, GERMÁN ARTURO BOHORQUEZ MAHECHA, CLEIDA APARECIDA DE
OLIVEIRA
D - 60
FECUNDITY AND VITELLOGENIC OOCYTE DIAMETER ASSESSMENT
OF LAMBARI ASTYANAX FASCIATUS INHABITING EDCS CONTAMINATED WATERS
IN FURNAS RESERVOIR, GRANDE RIVER, BRAZIL ANA PAULA BARBOSA PINHEIRO,
PAULA SUZANNA PRADO, JÉSSICA FIGUEIREDO ABREU, ELIZETE RIZZO
D - 77
EFFECT OF NEEM OIL (AZADIRACHTA INDICA A. JUSS) ON
MORPHOLOGY OF THE TESTIS OF CERAEOCHRYSA CLAVERI (NAVÁS, 1911)
(NEUROPTERA: CHRYSOPIDAE) ANA SILVIA GIMENES GARCIA, ELTON LUIZ
SCUDELER, MONIQUE CAMPOS PEREIRA, PATRICIA FERNANDA FELIPE PINHEIRO,
DANIELA CARVALHO DOS SANTOS
D - 61
STRUCTURAL AND ULTRASTRUCTURAL ANALYSES OF OOCYTES OF
THE DANIO RERIO EXPOSED TO GLYPHOSATE NEIDE ARMILIATO, EVELISE MARIA
NAZARI, DIB AMMAR, YARA MARIA RAUH MÜLLER
D - 78
THE OOGENESIS PROCESS DURING THE REPRODUCTIVE CYCLE OF
LOXOSCELES INTERMEDIA (ARANEAE: SICARIIDAE). EVERTON FOGAÇA, CLAUDIA
FEIJÓ ORTOLANI-MACHADO
D - 62
MORPHOLOGICAL AND CYTOCHEMICAL STUDIES OF PREGNANT
MOUSE UTERUS FROM NORMAL AND GENETIC MODIFIED MOUSE AFTER
EMBRYONIC LESION RAQUEL MEZZALIRA RUANO, ÉVILA DA SILVA LOPES SALLES,
ANDREA MOLLICA DO AMARANTE PAFFARO, BARBARA ANNE CROY, ÁUREO
TATISUMI YAMADA, VALDEMAR ANTONIO PAFFARO JUNIOR
D - 79
ASSESSMENT OF SPERMATOGENESIS AND DIAMETER OF
SEMINIFEROUS TUBULES IN THE LAMBARI ASTYANAX FASCIATUS FROM
CONTAMINATED SITES IN FURNAS RESERVOIR, GRANDE RIVER, BRAZIL ANA
PAULA BARBOSA PINHEIRO, PAULA SUZANNA PRADO, FABRÍCIO FLÁVIO
THEOPHILO DOMINGOS, ELIZETE RIZZO
D - 63
PLACENTAL INDOLEAMINE 2,3-DIOXYGENASE (IDO) ACTIVITY IN
RENAL-TRANSPLANTED PREGNANT WOMEN KAREN MATIAS DO PRADO, SIMONE
CORREA DA SILVA, LEANDRO GUSTAVO OLIVEIRA, SILVANA SANDRI, LARISSA DE SÁ
LIMA, MELISSA CAVALHEIRO TOURINO, ANA CAMPA, CRISTOFORO SCAVONE,
NIELS OLSEN SARAIVA CAMARA, ESTELA BEVILACQUA
D - 80
SPERMATOGENIC CYCLE LENGTH AND SPERM PRODUCTION IN A
FRESHWATER TURTLE KINOSTERNONSCORPIOIDES ALANA LISLEA DE SOUSA,
PAULO HENRIQUE ALMEIDA CAMPOS- JUNIOR, GUILHERME MATTOS JARDIM
COSTA, LUIZ RENATO DE FRANÇA
D - 64
SPERM
MORPHOLOGY
OF
RHYZOPERTHA
DOMINICA
(COLEOPTERA: BOSTRICHIDAE) GLENDA DIAS, HELEN PINTO SANTOS, JOSÉ LINONETO
D - 65
IMMUNOLOCALIZATION OF HOMOGALACTURONAN PECTINS,
ARABINOGALACTAN PROTEINS AND HEMICELLULOSES IN THE FILIFORM
APPARATUS OF PITCAIRNIA ENCHOLIRIOIDES L.B.SM. (BROMELIACEAE) SIMONE
PETRUCCI MENDES, ALEXANDRA A. MASTROBERTI, JORGE E. A. MARIATH,
RICARDO C. VIEIRA, KAREN L. G. DE TONI
D - 66
POLYMORPHISM OF SPERMATOZOA IN THE INSECT TRYPOXYLON
(HYMENOPTERA: CRABRONIDAE) LUIZ FERNANDO GOMES, UYRÁ ZAMA, HELEN
PINTO SANTOS, JOSÉ LINO-NETO
D - 67
AQUAPORIN-9 LOCALIZATION IN THE GERBIL EPIDIDYMIS DURING
POSTNATAL DEVELOPMENT CARLA DE MORAES MACHADO, WELLERSON
RODRIGO SCARANO, PATRICIA FERNANDA FELIPE PINHEIRO, WAGNER JOSÉ
FÁVARO, RAQUEL FANTIN DOMENICONI
D - 68
SPERMATOGONIAL STEM CELL NICHE IN THE SEXUALLY MATURE
BULLFROG (LITHOBATES CATESBEIANUS) LUIZ HENRIQUE DE CASTRO ASSIS,
FERNANDA VIEIRA DA SILVA CRUZ, TÂNIA MARA SEGATELLI, LUIZ RENATO DE
FRANÇA
D - 69
MATERNAL OBESITY AND POSTNATAL OVERNUTRITION IMPAIRS
LEYDIG CELLS FUNCTION IN ADULT RATS MARIA ETELVINA PINTO, THIAGO FERES
PISSOLATO, DANIELE LISBOA RIBEIRO, REJANE MAIRA GÓES
D - 70
DURATION OF SPERMATOGENESIS IN THE SPINY-RAT,
PROECHIMYS GUYANNENSIS (RODENTIA: ECHIMYIDAE) NATHÁLIA DE LIMA E
MARTINS LARA, IVAN CARLOS DOS SANTOS, GUILHERME MATTOS JARDIM COSTA,
PAULO HENRIQUE ALMEIDA CAMPOS-JUNIOR, ANA PAULA MADUREIRA, MARCOS
SANTOS ZANINI, LUIZ RENATO DE FRANÇA
D - 71
FECUNDITY, OOCYTE DIAMETER, GONADAL MATURATION AND
GONADOSSOMATIC INDEX OF THE CURIMBATÁ PROCHILODUS LINEATUS IN
THREE SECTIONS OF THE GRANDE RIVER BASIN, DOWNSTREAM FROM THE
PORTO COLOMBIA DAM. VIOLETA DA ROCHA PERINI, CLÁUDIA KELLY FERNANDES
CRUZ, NILO BAZZOLI, ELIZETE RIZZO
D - 72
COLLARED PECCARY (TAYASSU TAJACU) SPERMATOGENESIS
PROGRESSION AND DE NOVO TESTIS MORPHOGENESIS FROM TESTIS TISSUE
AND CELL SUSPENSION ECTOPICALLY XENOGRAFTED IN IMMUNODEFICIENT
MICE PAULO HENRIQUE DE ALMEIDA CAMPOS JUNIOR, G. M. J. COSTA, S. M. S. N.
LACERDA, G. F. AVELAR, D. A. A. GUIMARÃES, P. R. KAHWAGE, L. R. FRANÇA
D - 73
SELF-RENEWAL AND EXPANSION OF NILE-TILAPIA (OREOCHROMIS
NILOTICUS) SPERMATOGONIAL STEM CELLS IN CULTURE SAMYRA MARIA DOS
SANTOS NASSIF LACERDA, MARIANA DE ARAÚJO DA SILVA, GUILHERME MATTOS
JARDIM COSTA, PAULO HENRIQUE ALMEIDA CAMPOS-JÚNIOR, TÂNIA MARA
SEGATELLI, LUIZ RENATO DE FRANÇA
D - 74
DEVELOPMENT OF A CRYOPRESERVATION PROTOCOL FOR
SPERMATOGONIAL STEM CELL IN HORSES GUILHERME MATTOS JARDIM COSTA,
G. F. AVELAR, J. V. REZENDE-NETO, S. M. S. N. LACERDA, P. H. A. CAMPOS- JÚNIOR,
F. G. P. MARTINS, L. R. FRANÇA
D - 75
DISTRIBUTION OF ESTROGEN RECEPTORS ERALPHA AND ERBETA
IN THE PROSTATE AND AMPULLARY GLANDS OF BIG FRUIT-EATING BAT
ARTIBEUS LITURATUS DURING THE ANNUAL REPRODUCTIVE CYCLE. GABRIEL
HENRIQUE CAMPOLINA SILVA, REGIANA LUCIA DE OLIVEIRA, JOSÉ CARLOS
D - 81
EXTENUATING EXERCISE INCREASES THE UNK CELLS NUMBER AND
DECREASES EMBRYO VIABILITY IN PREGNANT MOUSE YAN TEIXEIRA FELBER,
KAMILA LEITE RODRIGUES, CAMILA A BRAGA, ANDREA MOLLICA AMARANTE
PAFFARO, VALDEMAR ANTONIO PAFFARO JUNIOR
D - 82
TYPE A SPERMATOGONIA DISTRIBUTION IN THE TESTIS OF
SEXUALLY MATURE NILE-TILAPIA (OREOCHROMIS NILOTICUS) PEDRO MANUEL
APONTE GARCIA, TÂNIA MARA SEGATELLI, LUCAS SANTOS E SOUZA, LUIZ RENATO
DE FRANÇA
D - 83
CIRCADIAN PROTEINS CLOCK AND BMAL1 IN THE CHROMATOID
BODY, A RNA GRANULE OF MALE GERM CELLS RITA LUIZA PERUQUETTI, PAOLO
SASSONE-CORSI
D - 84
ETHNOMEDICINES USED IN ALFENAS (BRAZIL) FOR FEMALE
REPRODUCTIVE DISORDERS JULIANE DE LIMA PASSOS, FERNANDO FELICIONI, ANA
FLÁVIA GONTIJO PIMENTA, GIOVANA BARBARINE LONGATO, VALDEMAR
ANTÔNIO PAFFARO JÚNIOR, ANDRÉA MOLLICA DO AMARANTE PAFFARO
D - 85
EFFECTS OF THE FUNGICIDE TEBUCONAZOLE ON LEYDIG CELLS
FROM THE FRUGIVOROUS BATS ARTIBEUS LITURATUS (OLFERS, 1818) DIANE DA
CRUZ MIRANDA, ÉRICA RITA DOS SANTOS LEITE, TÚLIO FIORINI CARVALHO,
RAQUEL ARMINDA CARVALHO MACHADO, DANIELA VALENTE DE ANDRADE,
MIRLAINE SOARES BARROS, ALESSANDRO BRINATI, MARIANA MACHADO NEVES,
MARIELLA BOMTEMPO DUCA DE FREITAS, SÉRGIO LUIS PINTO DA MATTA
D - 86
KARYOTYPE OF TRIATOMA MELANOCEPHALA (HEMIPTERA:
REDUVIIDAE) CAMILA HELENA FACINA, KAIO CESAR CHABOLI ALEVI, MARIA
TERCÍLIA VILELA DE AZEREDO OLIVEIRA
D - 87
ARTEMISININ INCREASES UTERINE NATURAL KILLER CELL NUMBER
AND CAUSES EMBRYO LOSS DURING MOUSE PREGNANCY FERNANDO FELICIONI,
KAMILA LEITE RODRIGUES, VALDEMAR ANTÔNIO PAFFARO JÚNIOR, ANDRÉA
MOLLICA DO AMARANTE PAFFARO
D - 88
ANALYSIS OF VIMENTIN EXPRESSION IN MICE CHORIOALLANTOIC
PLACENTAL TROPHOBLAST GIANT CELLS PEDRO LUIZ ANDRADE SCHERHOLZ, DIVA
DENELLE SPADACCI-MORENA, SIMA GODOSEVICIUS KATZ
D - 89
ACUTE EFFECT OF THE FUNGICIDE MANCOZEB ON LEYDIG CELLS
CRUZ MIRANDA, ÉRICA RITA DOS SANTOS LEITE, TÚLIO FIORINI CARVALHO,
RAQUEL ARMINDA CARVALHO MACHADO, DANIELA VALENTE DE ANDRADE,
MIRLAINE SOARES BARROS, ALESSANDRO BRINATI, MARIANA MACHADO NEVES,
MARIELLA BONTEMPO DUCA DE FREITAS, SÉRGIO LUIS PINTO DA MATTA
D - 90
ANNUAL REPRODUCTIVE CYCLE OF MALES OF THE FLAT-FACED
FRUIT-EATING BAT, ARTIBEUS PLANIROSTRIS (CHIROPTERA: PHYLLOSTOMIDAE)
MATEUS RODRIGUES BEGUELINI, CINTIA CRISTINA ISICAWA PUGA, SEBASTIÃO
ROBERTO TABOGA, ELIANA MORIELLE VERSUTE
D - 91
SENESCENCE AND PROSTATE: FIBROBLASTIC GROWTH FACTORS,
ANDROGEN AND PROLACTIN INTERACTIONS. AMANDA CIA HETZL, FABIO
MONTICO, LARISSA AKEMI KIDO, RAISA MISTIERI LORENCINI, EDUARDO MARCELO
CÂNDIDO, VALÉRIA HELENA ALVES CAGNON
D - 92
BIOCHEMICAL CHARACTERIZATION OF THE NUCLEAR ANNULUS OF
BULL SPERM AND ITS ASSOCIATION WITH CHROMATIN MOLINE SEVERINO
LEMOS, PRISCILA FERREIRA MOREIRA, ALBERTO DA SILVA MORAES, FÁBIO DE
OLIVEIRA, ROMUALDO MORANDI FILHO, MARCELO EMÍLIO BELETTI
D - 93
CYTOTOXIC EFFECTS OF SODIUM ARSENITE ON MICE SPERM CELLS
MARIA DE LOURDES GOMES PEREIRA, FERNANDO GARCIA E COSTA
103
D - 94
REPRODUCTIVE PARAMETERS OF DIABETIC RATS TREATED WITH
BRAZIL NUT EXTRACT OR SODIUM SELENITE LEONARDO PARREIRA SILVA
NASCIMENTO, VANESSA CARDOSO PIRES, DANIEL ARAKI RIBEIRO, ANDREA
PITTELLI BOIAGO GOLLUCKE, LUIS FILIPE DE OLIVEIRA FIGLIOLINO, HIROCHI
YAMAMURA, NATÁLIA MANZATTI MACHADO ALENCAR, ODAIR AGUIAR JUNIOR
D - 111
MATERNAL BEHAVIOR IN PREGNANCY AFTER TREATMENT WITH
HYDROALCOHOLIC EXTRACT OF CASSIA ANGUSTIFOLIA DURING EMBRYO
IMPLANTATION PERIOD RAFAELA SILVA DOS SANTOS, BRUNO ZAVAN, VALDEMAR
ANTÔNIO PAFFARO JÚNIOR, ANDRÉA MOLLICA DO AMARANTE PAFFARO
D - 95
AGING ALTERATIONS IN TESTIS AND EPIDIDYMIS: COULD
HETEROPTERYS TOMENTOSA IMPROVE THESE CHANGES? FABRICIA DE SOUZA
PREDES, MARIA APARECIDA DA SILVA DIAMANTE, JULIANA CASTRO MONTEIRO,
HEIDI DOLDER
D - 112
HISTOLOGICAL DESCRIPTION OF THE OOGENESIS OF HYPOSTOMUS
FRANCISCI (LÜTKEN, 1874) (SILURIFORMES, LORICARIIDAE) CAPTURED IN THE
ITAPECERICA RIVER, DIVINÓPOLIS, MG, BRAZIL. CAMILA FERREIRA SALES,
REGIANNE FERREIRA SILVA, MARILIA GABRIELA C AMARAL, ROSY I. MACIEL
AZAMBUJA RIBEIRO, FABRICIO FLÁVIO THEOPHILO DOMINGOS, RALPH GRUPPI
THOMÉ, HÉLIO BATISTA DOS SANTOS
D - 96
PROSTATIC STROMA FEATURES IN THE SENESCENCE AND
FOLLOWING ANTI-ANGIOGENIC THERAPY X STROMAL REACTIVITY DURING
CANCER PROGRESSION IN THE TRANSGENIC ADENOCARCINOMA OF MOUSE
PROSTATE (TRAMP) MODEL FABIO MONTICO, AMANDA CIA HETZL, EDUARDO
MARCELO CÂNDIDO, LARISSA AKEMI KIDO, RAÍSA MISTIERI LORENCINI, VALÉRIA
HELENA ALVES CAGNON
D - 113
STUDY OF SPERMATOGENESIS OF TRIATOMA JUAZEIRENSIS
(HEMIPTERA, REDUVIIDAE) KAIO CESAR CHABOLI ALEVI, PRISCILA PASQÜETTO
MENDONÇA, NATHÁLIA PAIVA PEREIRA, NAYARA FERNANDA DA COSTA CASTRO,
LARISSA CENTURION GANDOLPHI, MARIA TERCÍLIA VILELA DE AZEREDO OLIVEIRA
D - 97
DI-N-BUTYL-PHTHALATE (DBP) EFFECTS ON THE PROSTATE OF
ADULT RATS EXPOSED FROM THE FETAL PERIOD AND INITIATED BY MNU:
BIOMETRICAL, HORMONAL AND STEREOLOGICAL PARAMETERS TALITA MELLO
SANTOS, ANDRÉ REBELLO PEIXOTO, JOYCE ZALOTTI BRANDT, LEONARDO DE
OLIVEIRA MENDES, JOSÉ EDUARDO BOZANO, WAGNER JOSÉ FAVARO, RAQUEL
FANTIN DOMENICONI, JANETE A. ANSELMO-FRANCI, WELLERSON RODRIGO
SCARANO
D - 98
ANTIANGIOGENIC THERAPIES AND MOLECULAR RESPONSE OF THE
VENTRAL PROSTATE MICROENVIRONMENT IN ELDERLY MICE. LARISSA AKEMI
KIDO, AMANDA CIA HETZL, EDUARDO MARCELO CÂNDIDO, FABIO MONTICO,
RAÍSA MISTIERI LORENCINI, VALÉRIA HELENA ALVES CAGNON
D - 99
INCIDENCE OF LESIONS AND MAPK/AKT PATHWAY EVALUATION
IN THE ADULT RATS PROSTATE EXPOSED FROM THE FETAL PERIOD TO DI-NBUTYL-PHTHALATE (DBP) ANDRÉ REBELO PEIXOTO, TALITA DE MELLO SANTOS,
WAGNER JOSÉ FAVARO, PATRÍCIA FERNANDA F. PINHEIRO, RAQUEL FANTIN
DOMENICONI, SILVANA GISELE PEGORIN DE CAMPOS, SÉRGIO LUIS FELISBINO,
SEBASTIÃO ROBERTO TABOGA, WELLERSON RODRIGO SCARANO
D - 100
CHARACTERISTICS OF INTERACTION BETWEEN ESTROGEN AND
PROGESTERONE ON THE GERBIL PROSTATE RICARDO ALEXANDRE FOCHI, JULIA
QUILLES ANTONIASSI, LUIZ ROBERTO FALLEIROS JÚNIOR, SEBASTIÃO ROBERTO
TABOGA
D - 101
INFUSION AND EXTRACT OF ARTEMISIA VULGARIS IMPAIR MOUSE
PREGNANCY FERNANDO FELICIONI, PAULO SÉRGIO DE SOUZA PRIZMIC KIMAR,
VALDEMAR ANTÔNIO PAFFARO JÚNIOR, ANDRÉA MOLLICA DO AMARANTE
PAFFARO
D - 102
EFFECT OF PUNICA GRANATUM HIDROALCOHOLIC EXTRACT IN
MICE PAULO FERNANDO DE SOUZA JR, DANIELE ABUD QUAGLIANO, CAMILA
MIRANDA PERNAMBUCO, ALEXANDRE GIUST PAIVA, ANDREA MOLLICA DO
AMARANTE PAFFARO
D - 103
CONTRACEPTIVE POTENTIAL OF SUBCHRONIC ETHANOLIC
EXTRACT OF MAYTENUS ILICIFOLIA MART. EX REISSEK. IN FEMALE WISTAR RATS
SILVANE SOUZA ROMAN, CARLA GIANE LOSS, ASSIS ECKER, BRUNA CLAUDIA
COPPE, TAÍS REGINA FIORENTIN, ARNO ERNESTO HOFMANN JUNIOR
D - 104
MORPHOLOGICAL ASPECTS OF THE INITIAL STAGES OF
TOXOPLASMA GONDII INVASION IN THE HUMAN CHORIONIC VILLI SARA HISSAE
HIRAIWA, LETÍCIA DE SOUZA CASTRO FILICE, BRENO COSTA LANDIM, PRISCILA
SILVA FRANCO, ELOISA AMÁLIA VIEIRA FERRO, JULIANA GONZAGA DE OLIVEIRA
D - 105
ANTIANGIOGENIC THERAPY AND STEM CELL REACTIVITY OF THE
TRANSGENIC ADENOCARCINOMA OF MOUSE DORSOLATERAL PROSTATE
(TRAMP) MODEL VALÉRIA HELENA ALVES CAGNON, FABIO MONTICO, AMANDA
CIA HETZL, RAÍSA MISTIERI LORENCINI, LARISSA AKEMI KIDO, WAGNER JOSÉ
FÁVARO, MARCUS A. F. CORAT, DELMA P. ALVES, LUIZ A.C. PASSOS
D - 106
EFFECT OF SYZYGIUM CUMINI HIDROALCOHOLIC EXTRACT IN MICE
PREGNANCY RODOLFO CABRAL MARCELINO, WESLEY FERNANDES FONSECA
D - 107
DETERMINATION OF (AG ↓ CT) SEQUENCES IN T. TIBIAMACULATA
THROUGH RESTRICTION ENDONUCLEASE ALUI NAYARA FERNANDA DA COSTA
CASTRO, ADAUTO DE OLIVEIRA BORGUETI, ROSANA SILISTINO-SOUZA, LARISSA
CENTURION GANDOLPHI, MARIA TERCÍLIA VILELA DE AZEREDO-OLIVEIRA
D - 114
EFFECT OF INFUSION OF RUTA GRAVEOLENS IN THE PREIMPLANTATIONAL AND IMPLANTATIONAL PERIOD OF MICE PREGNANCY CAMILA
ALVARES BRAGA, WESLEY FERNANDES FONSECA, VALDEMAR ANTÔNIO PAFFARO
JÚNIOR, ANDRÉA MOLLICA DO AMARANTE PAFFARO
D - 115
DESCRIPTION OF SOMATIC AND GERM CELLS IN TESTIS OF
ARMORED CATFISH HYPOSTOMUS FRANCISCI (LÜTKEN, 1874) COLLECTED IN THE
PARAOPEBA RIVER, SÃO FRANCISCO RIVER BASIN, BRAZIL NATÁLIA RIBEIRO
ALVES, CAMILA FERREIRA SALES, FABRÍCIO FLÁVIO THEOPHILO DOMINGOS, RALPH
GRUPPI THOMÉ, FÁBIO PEREIRA ARANTES, YOSHIMI SATO, HÉLIO BATISTA DOS
SANTOS
D - 116
FECUNDITY AND OOCYTE DIAMETER OF THREE SPECIES FROM THE
GRANDE RIVER BASIN, DOWNSTREAM FROM THE PORTO COLOMBIA DAM: AN
COMPARATIVE ANALYSIS IN TWO SITES CLÁUDIA KELLY FERNANDES DA CRUZ,
VIOLETA DA ROCHA PERINI, ALESSANDRO PASCHOALINI LOUREIRO, NILO BAZZOLI,
ELIZETE RIZZO
D - 117
SPERMIOGENESIS ANALYSIS IN TWO CRYPTIC SPECIES OF
TRIATOMINES IN BRASILIENSIS SUBCOMPLEX KAIO CESAR CHABOLI ALEVI,
PRISCILA PASQÜETTO MENDONÇA, NATHÁLIA PAIVA PEREIRA, BRUNNO BOTELHO
BORGES, ANNA CLAUDIA CAMPANER LIMA, MARIA TERCÍLIA VILELA DE AZEREDO
OLIVEIRA
D - 118
HETEROCHROMATIN PATTERN IN HOLOCENTRIC CHROMOSOMES
OF TRIATOMA LENTI AND T. SHERLOCKI (HEMIPTERA: REDUVIIDAE) KAIO CESAR
CHABOLI ALEVI, PRISCILA PASQÜETTO MENDONÇA, NATHÁLIA PAIVA PEREIRA,
BRUNNO BOTELHO BORGES, ANNA CLAUDIA CAMPANER LIMA, MARIA TERCÍLIA
VILELA DE AZEREDO OLIVEIRA
D - 119
EFFECTS OF EXPERIMENTAL DIABETES IN INTERSTITIAL TISSUE AND
LEYDIG CELLS OF ADULT WISTAR RATS ALLUANAN ADELSON DO NASCIMENTO
SILVA, JESSICA SANTANA DE OLIVEIRA, OLÁVIO CAMPOS JÚNIOR, FERNANDA
CAROLINA RIBEIRO DIAS, RODRIGO RIBEIRO DE OLIVEIRA, SÍLVIA REGINA ARRUDA
DE MORAES, ELIZABETH NEVES DE MELO
D - 120
STROMAL CELL DERIVED FACTOR-2 (SDF-2) AT MATERNAL-FETAL
INTERFACE ALINE RODRIGUES LORENZON, SHAKER CHUCK FARAH, SUSAN J
FISHER, ESTELA BEVILACQUA
D - 121
CARUNCULES AND BOVINE ANTIGEN LEUKOCYTE (BOLA) DURING
PREGNANCY MARCELO EMÍLIO BELETTI, JULIANA MARTINS DA SILVA GALLO,
PATRÍCIA TERRA ALVES, SABRINA VAZ DOS SANTOS E SILVA, CARLOS UEIRA-VIEIRA
D - 122
BOLA (BOVINE ANTIGEN LEUKOCYTE) TRANSCRIPTS IN BOVINE
BLASTOCYSTS AND COTYLEDONS MARCELO EMÍLIO BELETTI, JULIANA MARTINS
DA SILVA GALLO, CARLOS UEIRA-VIEIRA, PATRÍCIA TERRA ALVES, SABRINA VAZ
DOS SANTOS E SILVA
D - 123
ALTERATIONS IN WISTAR RATS FERTILITY BY RESTRICTION OF
PARADOXICAL SLEEP. ROMUALDO MORANDI FILHO, LARA IZABELLA FRANCO
MARIANO, ADRIANO LARA ZUZA, MOLINE SEVERINO LEMOS, MARCELO EMILIO
BELETTI
D - 124
STUDY OF THE NUCLEOLAR CYCLE OF TRIATOMA JUAZEIRENSIS
(HEMIPTERA: TRIATOMINAE) KAIO CESAR CHABOLI ALEVI, PRISCILA PASQÜETTO
MENDONÇA, NATHÁLIA PAIVA PEREIRA, NAYARA FERNANDA DA COSTA CASTRO,
LARISSA CENTURION GANDOLPHI, MARIA TERCÍLIA VILELA DE AZEREDO OLIVEIRA
D - 108
ANALYSIS WITH RESTRICTION ENDONUCLEASE HAEIII IN
TRIATOMINAE (HETEROPTERA, REDUVIIDAE) LARISSA CENTURION GANDOLPHI,
ADAUTO DE OLIVEIRA BORGUETI, ROSANA SILISTINO-SOUZA, NAYARA FERNANDA
DA COSTA CASTRO, MARIA TERCÍLIA VILELA DE AZEREDO OLIVEIRA
D - 125
GENE TWO OF NON-CLASSICAL BOVINE ANTIGEN LEUKOCYTE
(BOLA) TRANSCRIPTS QUANTIFICATION IN FETAL BOVINE PLACENTA LAYS
OLIVEIRA ROCHA, JULIANA MARTINS DA SILVA GALLO, CARLOS UEIRA-VIEIRA,
PATRÍCIA TERRA ALVES, SABRINA VAZ DOS SANTOS E SILVA, MARCELO EMÍLIO
BELETTI
D - 109
GERM CELLS DIFFERENTIATION IN VITRO: EXPLORING THE ROLE OF
EXTRACELLULAR MATRIX. MARISTELA TALIARI PIMENTA, CATARINA SEGRETI
PORTO, MARIA DE FÁTIMA MAGALHÃES LAZARI
D - 126
EFFECTS OF STRESS BY PARADOXICAL SLEEP RESTRICTION ON
WISTAR RATS’ TESTIS. LARA IZABELLA FRANCO MARIANO, ROMUALDO MORANDI
FILHO, ADRIANO LARA ZUZA, MARCELO EMILIO BELETTI
D - 110
PRESENCE OF URETHRAL CORPUS SPONGIOSUM AND PROSTATE
(SKENE’S PARAURETHRAL GLANDS) IN FEMALE COATI THELMA MICHELLA SADDI,
FLÁVIO DE REZENDE GUIMARÃES, MANOEL FRANCISCO BIANCARDI, EUGÊNIO
GONÇALVES DE ARAÚJO, SEBASTIÃO ROBERTO TABOGA, WILIA MARTA ELSNER
DIEDERICHSEN DE BRITO, FERNANDA CRISTINA ALCANTARA DOS SANTOS
D - 127
RELATIONSHIP BETWEEN TUMOR NECROSIS FACTOR ALPHA AND
BOVINE BLASTOCYSTS PRODUCED IN VITRO ROMUALDO MORANDI FILHO,
JULIANA MARTINS DA SILVA GALLO, CARLOS UEIRA-VIERA, PATRÍCIA TERRA ALVES,
MARCELO EMÍLIO BELETTI
D - 128
COMPONENT OF BIRTH CONTROL PILL ADMINISTERED DURING
GESTATION AND PUBERTY ALTERS THE MORPHOPHYSIOLOGY OF MALE AND
104
FEMALE PROSTATE OF SENIL GERBIL ANA PAULA DA SILVA PEREZ, MANOEL
FRANCISCO BIANCARDI, LUIZ ROBERTO FALLEIROS JUNIOR, FERNANDA CRISTINA
ALCÂNTARA DOS SANTOS, SEBASTIÃO ROBERTO TABOGA
D - 129
DIABETES AND GLYCEMIC CONTROL: STEM CELL REACTIVITY IN
THE PROSTATIC MICROENVIRONMENT RAÍSA MISTIERI LORENCINI, AMANDA CIA
HETZL, EDUARDO MARCELO CÂNDIDO, FABIO MONTICO, LARISSA AKEMI KIDO,
WAGNER JOSÉ FÁVARO, VALÉRIA HELENA ALVES CAGNON
D - 130
MORPHOLOGICAL CHARACTERIZATION OF TOROIDAL STRUCTURES
IN SPERM CHROMATIN OF BULL, TURKEY, AND HUMAN ADRIANO LARA ZUZA,
ELISSON TERÊNCIO SOUZA, ROMUALDO MORANDI FILHO, MARCELO EMÍLIO
BELETTI
D - 131
ROLE OF THE ENTHESIS ON PUBIC SYMPHYSIS RECOVERY DURING
POSTPARTUM BIANCA GAZIERI CASTELUCCI, SÍLVIO ROBERTO CONSONNI, VIVIANE
DE SOUZA ROSA, HENRIQUE MARQUES-SOUZA, PAULO PINTO JOAZERIO
D - 132
EFFECT OF LOW PROTEIN DIET (CASEIN 8%) DURING THE
INTRAUTERINE AND LACTATIONAL PERIODS ON TUBULAR LUMENATION AND
GERM CELLS DEVELOPMENT IN THE TESTIS OF IMMATURE WISTAR RATS JESSICA
SANTANA DE OLIVEIRA, ALLUANAN ADELSON DO NASCIMENTO SILVA, OLÁVIO
CAMPOS JUNIOR, FERNANDA CAROLINA RIBEIRO DIAS, CAROLINA PEIXOTO
MAGALHÃES, SANDRA LOPES SOUSA, ELIZABETH NEVES DE MELO
D - 133
EXPOSURE TO TESTOSTERONE DURING PRENATAL LIFE INCREASES
THE SUSCEPTIBILITY TO THE DEVELOPMENT OF PROSTATIC LESIONS IN OLD
FEMALE GERBIL (MERIONES UNGUICULATUS) MANOEL FRANCISCO BIANCARDI,
ANA PAULA SILVA PEREZ, LUIZ ROBERTO FALLEIROS-JR, FERNANDA CRISTINA
ALCANTARA DOS SANTOS, REJANE MAIRA GÓES, SEBASTIÃO ROBERTO TABOGA
D - 134
ACUTE EFFECT OF THE FUNGICIDE MANCOZEB ON DIAMETER OF
THE NUCLEUS AND NUMBER OF ESPERMATOGENIC CELLS AND SERTOLI CELLS
CRUZ MIRANDA, TÚLIO FIORINI CARVALHO, RAQUEL ARMINDA CARVALHO
MACHADO, DANIELA VALENTE DE ANDRADE, MIRLAINE SOARES BARROS,
ALESSANDRO BRINATI, MARIANA MACHADO NEVES, MARIELLA BONTEMPO DUCA
DE FREITAS, SÉRGIO LUIS PINTO DA MATTA
D - 135
EFFECT OF THE FUNGICIDE TEBUCONAZOLE ON DIAMETER OF THE
NUCLEUS AND NUMBER OF ESPERMATOGENIC CELLS AND SERTOLI CELLS FROM
THE FRUGIVOROUS BATS ARTIBEUS LITURATUS (OLFERS, 1818) DIANE DA CRUZ
MIRANDA, TÚLIO FIORINI CARVALHO, RAQUEL ARMINDA CARVALHO MACHADO,
DANIELA VALENTE DE ANDRADE, MIRLAINE SOARES BARROS, ALESSANDRO
BRINATI, MARIANA MACHADO NEVES, MARIELA BONTEMPO DUCA DE FREITAS,
SÉRGIO LUÍS PINTO DA MATTA
D - 136
USING FLUORESCENT MARKERS FOR ASSESSING SPERM DAMAGE
IN COLLARED PECCARIES (TAYASSU TAJACU) CAUSED BY SEMEN
CRYOPRESERVATION MARIANA DE ARAÚJO DA SILVA, GISLAYNE CHRISTIANNE
XAVIER PEIXOTO, THIBÉRIO DE SOUZA CASTELO, MOACIR FRANCO DE OLIVEIRA,
GABRIELA LIBERALINO LIMA, JOSÉ ARTHUR BRILHANTE BEZERRA, ALEXANDRE
RODRIGUES SILVA
D - 137
PROLONGED BISPHENOL-A EXPOSURE STIMULATES EPITHELIAL
PROLIFERATION WHICH LEADS TO THE DEVELOPMENT OF A HYPERPLASIC
GLAND IN THE ADULT FEMALE GERBIL MÔNICA SOUSA CAMPOS, MANOEL
FRANCISCO BIANCARDI, ANDRÉ VILELA GALVÃO, RODRIGO FERNANDES DE LIMA,
JOSIANE FAGANELLO, MARA RÚBIA MARQUES, FERNANDA CRISTINA ALCÂNTARA
DOS SANTOS, LUIZ ROBERTO FALLEIROS-JR, SEBASTIÃO ROBERTO TABOGA
D - 138
REPRODUCTIVE
TOXICITY
OF
MULTI-WALLED
CARBON
NANOTUBES IN MICE. ALEXANDRA NAVA, SOLANGE CRISTINA DA SILVA MARTINS
HOELZEL, SILVANE SOUZA ROMAN
D - 139
EXPRESSION OF CHEMOKINE (C-C MOTIF) LIGAND 25 DURING
MOUSE EMBRYO IMPLANTATION RODRIGO BARBANO WEINGRILL, M. S.
HOSHIDA, C. D. MARTINHAGO, E. BEVILACQUA
D - 140
DEVELOPMENT OF A CHIMERIC EQUID TESTIS USING THE CELL
AGGREGATE XENOGRAFTING APPROACH G.F. AVELAR, G.M.J. COSTA, J.V.
REZENDE-NETO, S.M.S.N. LACERDA, P.H.A. CAMPOS-JÚNIOR, B.S.C. ANDRADE, L.R.
FRANÇA
E – Cell Biology and
Education
E1-E12
E -1
CONSTRUCTION OF DIDACTIC-PEDAGOGICAL MODELS FOR CELL
BIOLOGY TEACHING JOÃO PAULO FERREIRA SCHOFFEN, ISABELLA MARIA DIAS
PAYÃO ORTIZ, JEAN LUCAS KREMER, PRISCILA EUNICE DA SILVA, MATHEUS
EDUARDO LEME, ANA CAROLINA CORREIA AMBRÓSIO, FRANCIELY PALIARIN,
CARLOS VINÍCIUS DALTO DA ROSA, KARLA FERNANDA FERRAZ, LUCILENE CRISTINA
DA SILVA, ALINE NAZARENO
E -2
CONSTRUCTION OF DIDACTIC-PEDAGOGICAL MODELS FOR
EMBRYOLOGY TEACHING JOÃO PAULO FERREIRA SCHOFFEN, CRISTINA ALVES
FONSECA, ISABELLA MARIA DIAS PAYÃO ORTIZ, YURI FUJIMORI, BEATRIZ MAYARA
LIMA OKISHI, TAYEME CRISTINA PIVA, ROSANA CAMPOS PASCHOALINO, JULIANA
HADDAD, FABIANA APARECIDA MARTINS, LUIZ EDUARDO LOURENÇO SOUZA
E -3
THREE-DIMENSIONAL CELL MODELS AS A TEACHING TOOL FOR
CELL BIOLOGY COURSE IN THE BACHELOR IN SCIENCE AND TECHNOLOGY (BC&T)
AT UNIVERSIDADE FEDERAL DO ABC (UFABC) ARNALDO R. SANTOS JR., RENATA
SIMÕES, MARCELLA P. MILAZZOTTO, CHRISTIANE B. LOMBELLO
E -4
CELL BIOLOGY IN THE PROCESSES OF SCIENTIFIC RESEARCH IN
PUBLIC HIGH SCHOOL TATIANE DA AQUINO, PAULO RICARDO DA ROSA, JULIANE
MEILI, TANIA BERNHARD
E -5
DESCRIPTION OF A PEDAGOGICAL EXPERIMENT ON BUILDING
UNDERGRADUATE STUDENTS’ CLINICAL THINKING COUPLED UP WITH CELLULAR
PROCESSES AND BIOCHEMISTRY UNDERSTANDING LETICIA VARGAS DE
MESQUITA, CAROLINA ÁVILA DE ALMEIDA, CARLOS EDUARDO ABBUD HANNA
ROQUE, RICARDO FELIPE ALVES MOREIRA, CRISTIANE BARBOSA ROCHA
E -6
IN VIVO OR IN CITO: CAN THE CELL REPLACE THE ANIMAL? – A
DOCUMENTARY BEATRIZ LOUREIRO DE SOUZA, RÓBER BACHINSKI, LETÍCIA
APARECIDA BARBOSA HUMMEL, GUTEMBERG GOMES ALVES
E -7
PRACTICAL LESSONS IN THE LABORATORY AS A PROPOSAL TO
BETTER TEACH CELL BIOLOGY TO HIGH SCHOOL STUDENTS FERNANDA SILVA DE
SOUZA, LACI GONÇALVES VIANA, RENATO AUGUSTO DAMATTA
E -8
OPINION ON THE USE AND IMPORTANCE OF PRACTICAL LESSONS
AND THE EFFECT OF A CONTINUOUS EDUCATION COURSE IN CELL BIOLOGY
CONCEPTS TO HIGH SCHOOL TEACHERS FROM THE NORTHERN STATE OF RIO DE
JANEIRO. ALINE BRANDÃO ALVES LIMA, FERNANDA SILVA DE SOUZA, RENATO
AUGUSTO DAMATTA
E -9
AN INTEGRATED PRACTICAL COURSE ON CELL BIOLOGY BASED ON
A BIOMATERIAL CYTOCOMPATIBILITY PROJECT FOR HEALTH/BIOLOGY
UNDERGRADUATE STUDENTS DANIELA COSTA SILVA, JULIANA ALVES CÔRTES,
ROBER FREITAS BACHINSKI, GUILHERME LECHUGAR, CAROLINA NASCIMENTO
SPIEGEL, GUTEMBERG GOMES ALVES
E -10
GETTING OUT OF THE CAMPUS! PRESENTING THE PROGRESS OF
RESEARCH IN CELL BIOLOGY FOR HIGH SCHOOL TEACHERS BÁRBARA CAPITANIO
DE SOUZA, ANNA CHRISTINA MEDEIROS FOSSATI, LENIR ORLANDI PEREIRA,
SIMONE MARCUZZO, RUI FERNANDO FELIX LOPES, TATIANA LUFT, EMERSON
CASALI, MARCELO LAZZARON LAMERS
E -11
EDUCATION WITH TECHNOLOGY: THE USE OF AN ADAPTIVE
INTERFACE FACILITATES THE TEACHING AND LEARNING OF CELL BIOLOGY.
MAYARA LUSTOSA DE OLIVEIRA, HERNANDES FAUSTINO DE CARVALHO
E -12
“CELLULAR DOMINATION”: A POWERFUL TOOL FOR TEACHING
CELL BIOLOGY KRISIA EMANUELLE FERREIRA DA SILVA, THAÍS PRISCILA DE SOUZA
TORRES, MARLLON ALEX NASCIMENTO SANTANA, JÉSSICA ANDRÉIA PEREIRA
BARBOSA, JEYMESSON RAPHAEL CARDOSO VIEIRA
F – Cell Cycle and
Proliferation
F1-F27
F-1
PMA ANTAGONISTIC EFFECTS ON PROLIFERATION OF
IMMORTALIZED HUMAN HACAT KERATINOCYTES: STIMULATION OF NORMAL
AND INHIBITION OF H-RASV12-TRANSFORMED CELLS JULIANNA DIAS ZEIDLER,
HUGO AGUIRRE ARMELIN
F-2
P53, KI-67, COX-2 EXPRESSION IN RAT TONGUE EXPOSED TO
STEROIDS RENAN POZZI, KELLY ROSSETTI FERNANDES, CAROLINA FOOT GOMES
MOURA, ANA CLAUDIA MUNIZ RENNO, DANIEL ARAKI RIBEIRO
F-3
EFFECT OF UVA AND UVB ON THE NEURONS’ CELL CYCLE OF THE
CENTRAL OLFACTORY SYSTEM OF THE CRAB UCIDES CORDATUS. GABRIELA
HOLLMANN, GABRIELLE DE JESUS FERREIRA, ÁLVARO LETÃO, RAFAEL LINDEN,
SILVANA ALLODI
F-4
THE INSULIN RECEPTOR TRANSLOCATES TO THE NUCLEUS TO
REGULATE CELL PROLIFERATION AND LIVER REGENERATION. CLAUDILENE
R.CHAVES, MARIA JIMENA AMAYA, MARISA C.F. CASTELUBER, DOUGLAS L.
ALMEIDA, MAURO C.X. PINTO, LILIAN A.M. ARANTES, LIDIA MARIA ANDRADE, ANA
C.N. PINHEIRO, EMERSON A. FONSECA, GUSTAVO B. MENEZES, ANA MARIA DE
PAULA, RODRIGO RIBEIRO RESENDE, MICHAEL H. NATHANSON, MARIA DE FÁTIMA
LEITE
F-5
EFFECTS OF LOW INTENSITY RED LASER ON BACTERIAL GROWTH
AND PLASMIDS DNA JULIANA NOGUEIRA DOS SANTOS, CAMILA ROOS, FLAVIA DE
105
PAOLI, OSCAR ROBERTO GUIMARÃES, MAURO GELLER, ADENILSON DE SOUZA DA
FONSECA
F-6
GENOTOXIC EFFECTS ON ERYTHROCYTES OF TILAPIA
(OREOCHROMIS NILOTICUS) EXPOSED CADMIUM AND AFTER DEPURATION
JULIANA MOREIRA MENDONÇA GOMES, HEDER JOSÉ RIBEIRO, MARCELA SANTOS
PROCÓPIO, JOSÉ DIAS CORRÊA JUNIOR
F-7
POSSIBLE ACTIVATION OF THE WNT/BETA-CATENIN SIGNALING
PATHWAY IN HYPERPLASIC PANCREATIC ISLETS OF PRE-DIABETIC MICE DANIELA
APARECIDA MASCHIO, RICARDO BELTRAME OLIVEIRA, CAROLINA PRADO DE
FRANÇA CARVALHO, CARLA BEATRIZ COLLARES-BUZATO, MARIANE RODRIGUES
DOS SANTOS
F-8
DECREASED CX36 ISLET CONTENT AND IMPAIRED COMPENSATORY
BETA CELL FUNCTION AND GROWTH IN RESPONSE TO HIGH FAT DIET IN LDL
RECEPTOR KNOCKOUT MICE RICARDO BELTRAME OLIVEIRA, CAROLINA PRADO DE
FRANÇA CARVALHO, DANIELA APARECIDA MASCHIO, ANTÔNIO CARLOS
BOSCHERO, HELENA COUTINHO FRANCO DE OLIVEIRA, CARLA BEATRIZ COLLARESBUZATO
F-9
DIFFERENTIAL LIPID ACCUMULATION IN BONE MARROW
STROMAL CELLS AND ITS INFLUENCE ON HEMATOPOIESIS IN VITRO. GABRIEL
FERRAZ DA SILVA, ANDERSON JUNGER TEODORO, GEORGIA CORREA ATELLA,
MARCELO EINICKER LAMAS, ALEX BALDUINO DE SOUZA, RADOVAN BOROJEVIC,
MARCIA CURY EL-CHEIKH
F - 10
IL-4 MODULATES THE PROLIFERATIVE EFFECT OF EGF IN RETINAL
CELLS GUSTAVO MATARUNA DA SILVA, LUIS EDUARDO GOMES BRAGA, ELIZABETH
GIESTAL DE ARAUJO
F - 11
EVALUATION OF IRON SUPPLEMENTED MEDIA CULTURE IN THE
CELLULAR VIABILITY AND GENOMIC STABILITY OF CELL LINES – MRC5 AND
HEPG2 ANA LÚCIA VARGAS ARIGONY CORTE, LARISSA MILANO, MICHELLE LIMA,
ANDRE JUNCHEM, CRISTIANO TRINDADE, MIRIANA MACHADO, DIANA BORDIN,
EDUARDO FILIPPI-CHIELA, GUIDO LENZ, DANIEL PRA, JOÃO ANTONIO PÊGAS
HENRIQUES
F - 12
SIGNS OF CELLULAR SENESCENCE IN ESTROGEN-INDUCED
PITUITARY HYPERPLASIA MARÍA EUGENIA SABATINO, JUAN PABLO PETITI, LILIANA
DEL VALLE SOSA, SILVINA GUTIÉRREZ, ALEXANDRA SUSANA LATINI, ALICIA INÉS
TORRES, ANA LUCÍA DE PAUL
F - 23
SIGNALING TRIGGERED BY THE NEUROPEPTIDE PACAP AND SHH
INTERACT IN THE CONTROL OF CELL PROLIFERATION IN THE DEVELOPING RETINA
THALINE DAIANNE FARIAS ALVES DE LIMA, BRIAN NJAINE, RAFAEL LINDEN,
MARIANA SOUZA DA SILVEIRA
F - 24
DOES 5-BROMO-2'-DEOXYURIDINE (BRDU) INFLUENCE THE
POSTNATAL DEVELOPMENT IN RATS? LÍVIA CLEMENTE MOTTA TEIXEIRA, SILVIA
HONDA TAKADA, VITOR YONAMINE LEE, MARIA INÊS NOGUEIRA, GILBERTO
FERNANDO XAVIER
F - 25
ENDOSYMBIOSIS IN TRYPANOSOMATIDS: THE SYMBIOTIC
BACTERIUM UNDERGOES COORDINATED DIVISION WITH THE HOST CELL
STRUCTURES. CAROLINA MOURA COSTA CATTA PRETA, FELIPE LOPES BRUM DA
SILVEIRA, CAMILA CRISTINA DA SILVA, SERGIO SCHENKMAN, MARIA CAROLINA
ELIAS, LUCIANA CIAPINA, LUIZ GONZAGA, ANA TEREZA VASCONSELOS,
WANDERLEY DE SOUZA, MARIA CRISTINA MACHADO MOTTA
F - 26
BALANCE OF ADIPOGENESIS AND APOPTOSIS MARKERS IN
MESENTERIC ADIPOSE TISSUE DURING THE DEVELOPMENT OF CANCER
CACHEXIA FELIPE DE OLIVEIRA FRANCO, FELIPE DOS SANTOS HENRIQUES,
KALTINAITIS BENETON NUNES HYPOLITO DOS SANTOS, PÂMELA VIEGAS KNÖBL,
RODRIGO XAVIER DAS NEVES, ROGERIO ANTONIO LAURATO SERTIÉ, CLAUDIO
SABURO SHIDA, SIDNEY BARNABÉ PERES, MIGUEL LUIZ BATISTA JÚNIOR
F - 27
THE EFFECTS OF 7-EPI-CLUSIANONE ON PROLIFERATIVE BEHAVIOR
OF HEPG2 CELLS IZABELLA LUIZ SUZUKI, EVANDRO LUÍS DE OLIVEIRA NIERO,
GLAUCIA MARIA MACHADO SANTELLI, MARCELO HENRIQUE DOS SANTOS,
MARISA IONTA
G – Cell Death
G1-G38
G-1
MITOCHONDRIAL ENERGY UTILIZATION IN YOUNG AND OLD
WORKER HONEYBEES (APIS MELLIFERA) HSU CHIN-YUAN, YU-LUNG CHUANG
G-2
CELLULAR DEGRADATION ACTIVITY IN YOUNG AND OLD WORKER
HONEYBEES (APIS MELLIFERA) CHAN YU-PEI, CHUANG YU-LUNG, HSU CHIN-YUAN
F - 13
THE EFFECTS OF CAMPTOTHECIN AND BERENIL ON
ULTRASTRUCTURE OF TRYPANOSOMA CRUZI EPIMASTIGOTE FORM ALINE
ARAUJO ZUMA, MARIA CAROLINA ELIAS, WANDERLEY DE SOUZA, MARIA CRISTINA
MACHADO MOTTA
G-3
EFFECTS OF DISTURBED ENVIRONMENTS IN THE LIVER OF
PROCHILODUS LINEATUS BRUNO FIORELINI PEREIRA, JOSÉ ALGUSTO SENHORINI,
RITA DE CÁSSIA GIMENES DE ALCÂNTARA ROCHA, FLAVIO HENRIQUE CAETANO
F - 14
TRANSFORMING GROWTH FACTOR BETA1 PROMOTES P27KIP1
POST-TRANSCRIPTIONAL REGULATION IN GASTRIC CELLS OF SUCKLING RATS ANA
PAULA ZEN PETISCO FIORE, EUNICE RIBEIRO DE ANDRADE SÁ, LUCIANA HARUMI
OSAKI, CRUZ ALBERTO MENDOZA RIGONATTI, PATRICIA GAMA
G-4
CHARACTERIZATION
OF
DUAL
EFFECTS
INDUCED
BY
ANTIMICROBIAL PEPTIDES: REGULATED CELL DEATH OR MEMBRANE
DISRUPTION EDGAR JULIAN PAREDES GAMERO, MARTA NC MARTINS, FÁBIO AM
CAPPABIANCO, JAIME S IDE, ANTIONIO DE MIRANDA
F - 15
EVALUATION OF GASTRIC CANCER CELL PROLIFERATION AND
ADHESION IN CELL CULTURE PLATES SUBMITTED TO CORONA AND GLOW
DISCHARGE (PLASMA) PROCESSING WITH DIFFERENT N2/H2 RATIO RAQUEL
AYRES, FERNANDO BONATTO, DIEGO BONATTO
G-5
THE PARACRINE SIGNALING BY ATP/ ADP IS DETRIMENTAL
DURING THE STERILE CELL DEATH INDUCED BY ACETAMINOPHEN SYLVIA STELLA
AMARAL, PEDRO ELIAS MARQUES PEREIRA SILVA, LAURA LOPES NOGUEIRA PINTO,
DANIELE ARAÚJO PIRES, LÍDIA MARIA DE ANDRADE, MARIA DE FÁTIMA LEITE,
GUSTAVO BATISTA DE MENEZES
F - 16
CONSTITUTIVELY ACTIVE CDK1 TRIGGERS DNA DAMAGE AND CELL
CYCLE ARREST PATRÍCIA RENCK NUNES, KASIM DIRIL, PHILIPP KALDIS
F - 17
GHRELIN AND GROWTH HORMONE SECRETAGOGUE RECEPTOR
DISTRIBUTION IN THE GASTRIC MUCOSA OF EARLY WEANED RATS: EFFECTS ON
EPITHELIAL CELL PROLIFERATION. DANIELA OGIAS, NATALIA BITTAR RODRIGUES,
LUCIANA HARUMI OSAKI, CRUZ ALBERTO MENDOZA RIGONATTI, PATRICIA GAMA
F - 18
THE LEISHMANIA (L.) AMAZONENSIS CELL CYCLE: WHO
DUPLICATES FIRT, KINETOPLAST OR NUCLEUS? MARCELO SANTOS DA SILVA,
JOMAR PATRÍCIO MONTEIRO, ARINA MARINA PEREZ, MARIA CAROLINA ELIAS,
MARIA ISABEL NOGUEIRA CANO
F - 19
ACTIVATION OF C-JUN N-TERMINAL KINASE (JNK) DURING
MITOSIS IN RETINAL PROGENITOR CELLS. VINICIUS DE TOLEDO RIBAS, BRUNO DE
SOUZA GONÇALVES, RAFAEL LINDEN, LUCIANA BARRETO CHIARINI
F - 20
7-EPI-CLUSIANONE EXERTS A NEGATIVE EFFECT ON CELL CYCLE
PROGRESSION IN LUNG CARCINOMA CELLS TATIANE HELENA BATISTA, NATHALIE
NUNES DIAS, EVANDRO LUIS DE OLIVEIRA NIERO, MARISI GOMES SOARES,
GLAUCIA MARIA MACHADO-SANTELLI, MARCELO HENRIQUE DOS SANTOS,
MARISA IONTA
F - 21
LEISHMANIA AMAZONENSIS RBP38 IS PROBABLY INVOLVED IN
DNA DAMAGE RESPONSE IN THE NUCLEUS AND IN THE KINETOPLAST ARINA
MARINA PEREZ, MARCELO SANTOS DA SILVA, PAULO VINICIUS DA MATA
MADEIRA, BÁRBARA MORAES SOUZA, JULIA P. C. DA CUNHA, MARIA ISABEL
NOGUEIRA CANO
F - 22
CYTOTOXIC ACTIVITY OF 7-EPI-CLUSIANONE, A TETRAPRENYLATED
BENZOPHENONE, ON BREAST CANCER CELL LINES. NATALIA GABRIELE HOSCH,
IARA AUANA SALES, EVANDRO LUÍS DE OLIVEIRA NIERO, GLAUCIA MARIA
MACHADO-SANTELLI, MARCELO HENRIQUE DOS SANTOS, MARISA IONTA
G-6
TRICHOMONAS VAGINALIS: ULTRASTRUCTURAL ALTERATIONS
INDUCED BY BPQ-OH COMPARED TO METRONIDAZOLE AND EVALUATION OF ITS
CYTOTOXICITY IN MAMMALIAN CELLS DEBORA ROCHA AFONSO SILVA, IVONE
ROSA DE ANDRADE, WANDERLEY DE SOUZA, JULIO URBINA, MARLENE
BENCHIMOL
G-7
ANTI-APOPTOTIC HSP27 AND ITS TRANSCRIPTION FACTOR HSTF1
ARE UP-REGULATED BY PROLACTIN IN HUMAN PANCREATIC ISLETS ROSANGELA
APARECIDA WAILEMANN MANSANO, LETÍCIA FERREIRA TERRA, MARI CLEIDE
SOGAYAR, LETÍCIA LABRIOLA
G-8
CRUDE EXTRACT OF ANNONA MUCOSA (ANNONACEAE) CAUSES
CHANGES IN CELLS OF THE GUT OF AEDES AEGYPTI LARVAE (DIPTERA:
CULICIDAE) JAMILE FERNANDA SILVA COSSOLIN, MARILZA DA SILVA COSTA, JOSÉ
EDUARDO SERRÃO, MÔNICA JOSENE BARBOSA PEREIRA
G-9
MORPHOLOGICAL ASPECTS OF THE GUT REPLACEMENT IN
BRADYSIA HYGIDA (DIPTERA: SCIARIDAE) DURING METAMORPHOSIS THAYLISE
DE CASSIA SANTOS PRZEPIURA, JOSÉ ROSA GOMES, CRISTINA LÚCIA SANT’ANNA
COSTA-AYUB, MARIA ALBERTINA DE MIRANDA SOARES
G - 10
ANALYSIS OF PROTEIN EXPRESSION AFTER PHOTODYNAMIC
THERAPY IN THE PROTOZOAN PARASITE TRITRICHOMONAS FOETUS SUSANE
MOREIRA MACHADO, CRISTINA PACHECO SOARES, CRISTIANE APARECIDA
FERREIRA PIRES, FERNANDA ROBERTA MARCIANO, ANDERSON OLIVEIRA LOBO,
NEWTON SOARES DA SILVA
G - 11
GOLD NANOPARTICLES DO NOT INDUCE CYTOTOXICITY IN THE
ALVEOLAR TYPE-II CELL LINE CAROLINA DA SILVA GOUVEIA PEDROSA, TALÍRIA
SILVA LOPES, KARINA RIBEIRO DA SILVA, LEANDRA SANTOS BAPTISTA, PRISCILA
FALAGAN LOTSCH, GUSTAVO CONDE MENEZES, RADOVAN BOROJEVIC, JOSÉ
MAURO GRANJEIRO
106
G - 12
APOPTOSIS INDUCTION IN TUMOR CELLS BY A NATURAL
INTRACELLULAR PEPTIDE CHRISTIANE BEZERRA DE ARAUJO, EDNA T. KIMURA,
EMER SUAVINHO FERRO
G - 30
CYTOTOXICITY OF PHENOLIC COMPOUNDS ON HUMAN SKIN CELL
LINES. ANDRÉA COSTA FRUET, SILVYA STUCHI MARIA-ENGLER, SILVIA BERLANGA
DE MORAES BARROS
G - 13
EFFECTS OF THE BOTHROPOIDES INSULARIS VENOM (AMARAL,
1921) ON RENAL TUBULAR CELLS. CLARISSA PERDIGÃO MELLO, LOUISE
DONADELLO TESSAROLO, ALBA FABÍOLA COSTA TORRES, RAMON RÓSEO PAULA
PESSOA BEZERRA DE MENEZES, GUSTAVO JOSÉ DA SILVA PEREIRA, ISABEL
CRISTINA OLIVEIRA DE MORAIS, DÂNYA BANDEIRA LIMA, JÁDER ALMEIDA
CANUTO, ALICE MARIA COSTA MARTINS, SORAYA SOUBHI SMAILI
G - 31
APOPTOTIC RATES IN WISTAR RAT KIDNEYS TREATED WITH
CYCLOSPORIN A AND HETEROPTERYS TOMENTOSA. KARINE MOURA FREITAS,
MARIA APARECIDA DA SILVA DIAMANTE, JACQUELINE MERIELLEN DE ALMEIDA,
NAYARA RUDECK OLIVEIRA STHEL COCK, FABRICIA DE SOUZA PREDES, MARÇAL
AMICE JORGE, HEIDI DOLDER
G - 14
THE EFFECT OF EARLY WEANING ON APOPTOSIS IN THE GASTRIC
EPITHELIUM OF RATS IN POSTNATAL DEVELOPMENT CAMILA KAMLA
MARTINATTI, PATRÍCIA GAMA, CRUZ ALBERTO MENDONZA RIGONATI, LUCIANA
HARUMI OSAKI
G - 15
ANALYSIS OF GOLD NANOPARTICLES TOXICITY IN HUMAN FETAL
LUNG FIBROBLAST (MRC5) CELL CULTURE TALÍRIA SILVA LOPES, PRISCILA
FALAGAN LOTSCH, CAROLINA DA SILVA GOUVEIA PEDROSA, KARINA RIBEIRO DA
SILVA, LEANDRA SANTOS BAPTISTA, GUSTAVO CONDE MENEZES, JOSE MAURO
GRANJEIRO
G - 16
PHENOTHIAZINE-INDUCED HEPG2 CELL DEATH: STRUCTUREACTIVITY RELATIONSHIP AND MITOCHONDRIAL INVOLVEMENT PRISCILA AFONSO
DE FARIA, FELIPE SAMUEL PESSOTO, EDGAR JEAN PAREDES-GAMERO, TIAGO
RODRIGUES
G - 17
EFFECT OF PROTEIN MALNUTRITION IN THE MECHANISMS OF
APOPTOSIS, NECROSIS AND AUTOPHAGY IN MARROW HYPOPLASIA. JACKELINE
SOARES DE OLIVEIRA BELTRAN, GRAZIELA BATISTA DA SILVA, DALILA CUNHA DE
OLIVEIRA, ED WILSON DOS SANTOS, PRIMAVERA BORELLI
G - 18
DENGUE INFECTION RESULTS IN CELL DEATH OF HUMAN BRAIN
MICROVASCULAR ENDOTHELIAL CELLS MICHELLE PREMAZZI PAPA, LUCIANA
BARROS DE ARRUDA
G - 19
THE PROTECTIVE EFFECT AGAINST PHOTODAMAGE OF ALOE
BARBADENSIS MIL IN HUMAN KERATINOCYTES ANA CLAUDIA VIOTTO, NAYRA
FERNANDES SANTOS, CLEIDIANE SOUZA, DIVINOMAR SEVERINO, MAURÍCIO SILVA
BAPTISTA, WALESKA KERLLEN MARTINS
G - 20
INVOLVEMENT OF AUTOPHAGY IN THE PHENOTHIAZINE-INDUCED
APOPTOSIS IN K562 CELLS VIVIAN MATSUKURA DOS SANTOS, FABIO D.
NASCIMENTO, GISELLE ZENKER JUSTO, IVARNE LUIS DOS SANTOS TERSARIOL,
TIAGO RODRIGUES
G - 21
IN THE SEARCH FOR SPECIFIC MECHANISMS OF PHOTO-INDUCED
CELL DEATH NAYRA FERNANDES SANTOS, ISABEL DE OLIVEIRA LIMA BACELLAR,
ANA CLÁUDIA VIOTTO, CHRISTIANE PAVANI, WALESKA KERLLEN MARTINS,
MAURÍCIO DA SILVA BAPTISTA
G - 22
EFFECTS OF BOTHROPS MARAJOENSIS SNAKE VENOM AND ITS
FRACTION PHOSPHOLIPASE A2 ON RENAL TUBULAR CELLS AND MURINE
MACROPHAGES GDAYLLON CAVALCANTE MENESES, JÁDER ALMEIDA CANUTO,
LOUISE DONADELLO TESSAROLO, LÍVIA CORREIA FERNANDES, ALBA FABÍOLA
COSTA TORRES, TICIANA PRACIANO PEREIRA, JOSIANE S. QUETZ, HELENA SERRA
AZUL MONTEIRO, ALICE MARIA COSTA MARTINS
G - 23
PALLADACYCLE-INDUCED CASPASE-DEPENDENT APOPTOSIS IN
K562 LEUKEMIA CELLS IS ASSOCIATED TO THIOL OXIDATION AND
MITOCHONDRIAL DEPOLARIZATION VIVIAN WERLOGER RODRIGUES DE MORAES,
EDGAR JULIAN PAREDES-GAMERO, TIAGO RODRIGUES
G - 24
POLYMERIC MICELLAR SYSTEM POTENTIATES THE ANTITUMOR
ACTIVITY OF PHENOTHIAZINES IN HUMAN K562 LEUKEMIA CELLS JOYCE CRISTINE
DE MELLO, DEYSE CARDOSO DE SILVA, DANIELE RIBEIRO DE ARAÚJO, TIAGO
RODRIGUES
G - 25
NEEM SEED OIL EXHIBITS CONCENTRATION DEPENDENT DUAL
EFFECTS ON HEPG2 CELL VIABILITY: PROTECTION AGAINST OXIDATIVE STRESS
AND INDUCTION OF CELL DEATH PALOMA CAROLINE RIBEIRO, TIAGO RODRIGUES
G - 26
RENAL EFFECTS OF DINOPONERA QUADRICEPS VENOM ALBA
FABIOLA COSTA TORRES, JÁDER ALMEIDA CANUTO, LOUISE DONADELO
TESSAROLO, TICIANA PRACIANO PEREIRA, ANTONIO RAFAEL COELHO JORGE,
MILEYDE PONTE PORTELA, YVES PATRIC QUINET, HELENA SERRA AZUL MONTEIRO,
ALICE MARIA MARTINS
G - 27
PLUMBAGIN-INDUCED CELL DEATH IN LEUKEMIA MODEL IS
PROMOTED BY CELLULAR OXIDATIVE UNBALANCE MAYARA KAORI KISAKI, TIAGO
RODRIGUES
G - 28
SEX-RELATED DIFFERENCES ON HIPPOCAMPAL MITOCHONDRIAL
PROFILE INDUCED BY NEONATAL HYPOXIA-ISCHEMIA INJURY ANA PAULA
TONIAZZO, SIMONE NARDIN WEIS
G - 29
SEX-SPECIFIC EFFECTS OF AUTOPHAGY CELL DEATH IN NEONATES
FOLLOWING HYPOXIA-ISCHEMIA SIMONE NARDIN WEIS, ANA PAULA TONIAZZO,
BRADLEY P. ANDER, XINHUA ZHAN, MILO CAREAGA, PAUL ASHWOOD, FRANK RAY
SHARP, ANGELA TEREZINHA DE SOUZA WYSE, CARLOS ALEXANDRE NETTO
G - 32
REDUCTION OF COLLAGEN FIBERS AND CELL DEATH BY APOPTOSIS
IN THE LAMINA PROPRIA DURING STAGES OF TOOTH ERUPTION JOSÉ PAULO DE
PIZZOL JÚNIOR, ESTELA SASSO CERRI, PAULO SÉRGIO CERRI
G - 33
PROGRAMMED CELL DEATH IN AQUATIC BACTERIA IN TWO
TROPICAL AQUATIC ECOSYSTEMS MODELS THIAGO PEREIRA DA SILVA, JULIANA
GAMALIER, VICTOR ZARANTONELLO, FÁBIO ROLAND, ROSSANA CORREA NETTO DE
MELO
G - 34
IMPAIRED ENDOPLASMIC RETICULUM STRESS RESPONSE IN
LYMPHOCYTES FROM PATIENTS WITH BIPOLAR DISORDER BIANCA
PFAFFENSELLER, BIANCA WOLLENHAUPT DE AGUIAR, GABRIEL RODRIGO FRIES,
GABRIELA DELEVATI COLPO, RENAN KUBIACHI BURQUE, GIOVANA BRISTOT,
PÂMELA FERRARI, KEILA MENDES CERESÉR, FÁBIO KLAMT, FLÁVIO KAPCZINSKI
G - 35
IN VITRO ANTI-APOPTOTIC ACTIVITY OF OIL FROM SALVIA
LACHNOTASCHYS IN LYMPHOCYTES AND MACROPHAGES OF MUS MUSCULUS
LUCAS WAGNER GORTZ, MARCELO BETTEGA, LUIZA FERNANDA SCHIER, OSVALDO
MALAFAIA, CLAUDIA CONSUELO DO CARMO OTA
G - 36
ANTI-APOPTOTIC EFFECT OF A PROTEIN ISOLATED FROM PODALIA
SP (LEPIDOPTERA: MEGALOPYGIDAE) HEMOLYMPH IN VERO AND SF-9 CELLS
NATHALIA DELAZERI DE CARVALHO, ROBERTO HENRIQUE PINTO MORAES, RITA
MARIA ZUCATELLI MENDONÇA, RONALDO ZUCATELLI MENDONÇA
G - 37
IN VITRO ANTI-APOPTOTIC ACTIVITY OF OIL FROM COPAIFERA
LANGSDORFFII IN LYMPHOCYTES AND MACROPHAGES OF MUS MUSCULUS
MARCELO BETTEGA, LUCAS WAGNER GORTZ, LUIZA FERNANDA SCHIER, OSVALDO
MALAFAIA, CLAUDIA CONSUELO DO CARMO OTA
G - 38
DC-SIGN MEDIATES DENGUE VIRUS-INDUCED PLATELET
ACTIVATION, MITOCHONDRIAL DYSFUNCTION AND CELL DEATH EUGENIO
DAMACENO HOTTZ, MARCUS FERNANDES OLIVEIRA, ROGÉRIO VALLS DE SOUZA,
ANDRÉA THOMPSON DA POIAN, ANDREW S. WEYRICH, GUY A. ZIMMERMAN,
PATRÍCIA TORRES BOZZA, FERNANDO AUGUSTO BOZZA
G – 39
NFAT1 COOPERATES WITH RAS/RAF/MEK/ERK PATHWAY IN THE
INDUCTION OF APOPTOTIC AND NECROTIC CELL DEATH IN FIBROBLASTS. ROBBS,
B.K., VIOLA, J.P.B.
H – Cell Differentiation
H1-H19
H-1
THE INFLUENCE OF CORTICOSTERONE IN THE MATURATION OF
RAT GASTRIC MUCOSA DURING EARLY WEANING JULIANA GUIMARÃES ZULIAN,
CRUZ ALBERTO MENDOZA RIGONATI, PATRÍCIA GAMA
H-2
CHOLESTEROL DEPLETION ALTERS THE EXPRESSION OF ADHESION
PROTEINS AND CELL MIGRATION IN MYOBLASTS ANA CLAUDIA BATISTA
POSSIDONIO, CAROLINA PONTES SOARES, DÉBORA MORUECO PORTILHO, JULIANA
LOURENÇO ABRANTES, VICTOR DO VALLE PEREIRA MIDLEJ, MARLENE
BENCHIMOL, CLÁUDIA DOS SANTOS MERMELSTEIN
H-3
2D AND 3D-ORGANIZED CARDIAC CELLS SHOWS DIFFERENCES IN
CELLULAR MORPHOLOGY, ADHESION JUNCTIONS, PRESENCE OF MYOFIBRILS
AND PROTEIN EXPRESSION CAROLINA PONTES SOARES, VICTOR MIDLEJ, MARIA
EDUARDA WESCHOLLEK DE OLIVEIRA, MARLENE BENCHIMOL, MANOEL LUIS
COSTA, CLÁUDIA DOS SANTOS MERMELSTEIN
H-4
HIGH LEVELS OF CIRCULATING TRIIODOTHYRONINE INDUCES
PLASMA CELL DIFFERENTIATION IN MICE FLAVIA FONSECA BLOISE, FELIPE
OLIVEIRA, ALBERTO FÉLIX NÓBREGA, ALINE CORDEIRO, LUCIANA DE SOUZA PAIVA,
DENNIS D TAUB, RADOVAN BOROJEVIC, CARMEN CABANELAS PAZOS-MOURA,
VALÉRIA DE MELLO-COELHO
H-5
EFFECT OF THE LIPID-RAFT DISORGANIZATION ON THE MUSCULAR
CELL DIFFERENTIATION IN ZEBRAFISH MODEL EDUARDO ANDRÉS RÍOS MORRIS,
LAISE CAMPOS, CLAUDIA MERMELSTEIN, MANOEL LUÍS COSTA
H-6
CHARACTERIZATION OF HEMATOPOIETIC STEM/PROGENITOR
CELLS OBTAINED IN VITRO FROM HUMAN EMBRYONIC STEM CELLS IN COCULTURE SYSTEM WITH MOUSE EMBRYONIC FIBROBLASTS EVERTON DE BRITO
OLIVEIRA COSTA, MARISTELA DELGADO ORELLANA, DANIELLE APARECIDA ROSA
DE MAGALHÃES, VIRGÍNIA MARA DE DEUS WAGATSUMA, LILIAN FIGUEIREDO
MOREIRA, SIMONE KASHIMA HADDAD, DIMAS TADEU COVAS, APARECIDA MARIA
FONTES
107
H-7
RHOA GTPASES IS IMPORTANT FOR CELL DIFFERENTIATION IN
ORAL SQUAMOUS CELL CARCINOMA NANCI MENDES PINHEIRO, MARCO AURÉLIO
DE OLIVEIRA MARINHO, DOUGLAS CÔBO MICHELLI, BEATRIZ MARTINS TAVAREZ
MURTA, ANA CRISTINA DE ARAÚJO LEMOS, EURÍPEDES DE OLIVEIRA MARINHO,
MICHELLE TILLMMAN BIZ, VIRGÍNIA OLIVEIRA CREMA
H-8
INDUCTION OF CELLULAR DIFFERENTIATION AND THE MULTIDRUG
RESISTANCE PHENOTYPE MICHELE CARRETT DIAS GARCIA, LEDA KARINE DE
ALMEIDA, REGINA COIMBRA ROLA, ANA PAULA DE SOUZA VOTTO, GILMA SANTOS
TRINDADE
H-9
ASSESSMENT OF MINERALIZATION ON PRIMARY HUMAN BONE
CELLS HARVESTED FROM ARTHROPLASTY EXPLANTS WESLEY LUIZ BARROS DA
SILVA, MELLODY JESSICA BALLARD ARAGÃO, EMANUELLE STELLET LOURENÇO,
VINICIUS SCHOTT GAMEIRO, GUTEMBERG GOMES ALVES, JOSÉ MAURO
GRANJEIRO, ADRIANA BRANDÃO RIBEIRO LINHARES
H - 10
THE COMBINED USE OF RETINOIC ACID AND CAMP IS EFFECTIVE IN
INDUCING DIFFERENTIATION OF HEPG2 CELLS DEBORAH ELZITA DO CARMO
CORRÊA, CAMILLA CRISTINA MORI, PAULA REZENDE TEIXEIRA, GLAUCIA MARIA
MACHADO SANTELLI, MARISA IONTA
H - 11
B LYMPHOCYTES DIFFERENTIATE INTO PLASMA CELLS AFTER
TRIIODOTHYRONINE STIMULATION IN VITRO AND EXPRESS TRBETA1 HUILA
LUIZA SANTOS DA FONSECA, FLAVIA FONSECA BLOISE, ALINE CORDEIRO,
ALESSANDRA GRANATO, ALBERTO FÉLIX NÓBREGA, CARMEN CABANELAS PAZOSMOURA, VALÉRIA DE MELLO-COELHO
H - 12
PS20 AFFECTS UPA SECRETION AND THE BEHAVIOR OF
ENDOTHELIAL CELLS SILVIA BORGES PIMENTEL DE OLIVEIRA, HERNANDES F
CARVALHO
H - 13
EVALUATION OF THE NEUROTOXIC/NEUROPROTECTIVE ROLE OF
ORGANOSELENIDES USING DIFFERENTIATED HUMAN NEUROBLASTOMA SH-SY5Y
CELL LINE CHALLENGED WITH 6-HYDROXYDOPAMINE LEONARDO LISBOA DA
MOTTA, FERNANDA MARTINS LOPES, GIOVANA FERREIRA LONDERO, LIANA
MARENGO DE MEDEIRO, GUILHERME ANTONIO BEHR, VALESKA AGUIAR DE
OLIVEIRA, MOHAMED IBRAHIM, JOSÉ CLÁUDIO FONSECA MOREIRA, LISIANE DE
OLIVEIRA PORCIÚNCULA, JOÃO BATISTA TEXEIRA DA ROCHA, FÁBIO KLAMT
H - 14
ROLE OF STROTIUM RANELATE ON PROLIFERATION AND
OTEOGENIC DIFFERENTIATION OF HUMAN MESENCHYMAL STROMAL CELLS
RHAYRA BRAGA DIAS, DANIELLE C. BONFIM, RADOVAN BOROJEVIC, MARCOS
FARINA, MARIA ISABEL DORIA ROSI
H - 15
ROS INDUCES DIFFERENTIATION OF NORMAL AND LEUKEMIC
HEMATOPOIETIC CELLS AMANDA NOGUEIRA PEDRO, THALYTA APARECIDA
CESÁRIO MUNHOZ, CHRISTIANO MARCELLO VAZ BARBOSA, CAROLINA CARVALHO
DIAS, EDGAR JULIAN PAREDES-GAMERO, ALICE TEIXEIRA FERREIRA
H - 16
ESTABLISHMENT OF HEMOBLAST CULTURE FROM THE
HEMATOPOIETIC SITE OF THE SEA SQUIRT STYELA PLICATA ISADORA SANTOS DE
ABREU, SILVANA ALLODI, CÍNTIA MONTEIRO DE BARROS
H - 17
BOVINE TENDON EXTRACT SUPPORTS THE DIFFERENTIATION OF
ADULT HUMAN MESENCHYMAL STEM CELLS INTO TENOCYTE-LIKE CELLS. LÍVIA
MARIA MENDONÇA AUGUSTO, F. A. MENDES, M. I. D. ROSSI, A. S. BALDUINO, P. L.
CASADO, A. S. CAVALCANTE, V. F. VIANNA, D. C. BONFIM, J. F. M. BARCELLOS, M.
E. L. DUARTE
H - 18
EFFECT OF POLYAMINES ON THE CELLULAR MORPHOLOGY OF
YARROWIA LIPOLYTICA ANTONIO JESUS DORIGHETTO COGO, ARNOLDO ROCHA
FAÇANHA, ANNA LVOVNA OKOROKOVA FAÇANHA
H - 19
IN VITRO OSTEOBLASTIC DIFFERENTIATION ON BIOACTIVE GLASSBASED MATERIALS GABRIELA CAROLINE ALONSO, OLÍVIA CHERUBIN ALVES,
FABÍOLA SINGARETTI DE OLIVEIRA, ROGER RODRIGO FERNANDES, OSCAR PEITL,
EDGAR DUTRA ZANOTTO, MÁRCIO MATEUS BELOTI, ADALBERTO LUIZ ROSA,
PAULO TAMBASCO DE OLIVEIRA
I – Cell Migration
I1-I13
I-1
MORPHOLOGICAL AND BIOCHEMICAL ASPECTS OF A SUBACUTE
LESION IN THE PROTOCEREBRAL TRACT OF THE CRAB UCIDES CORDATUS
CLYNTON LOURENÇO CORREA, PAULA CHAVES DA SILVA, SILVANA ALLODI
I-2
PLASMIN AND UROKINASE PROMOTES CELL MIGRATION VIA
MEK/ERK CASCADE BRUNO ROCHA CORDEIRO COSTA, ALINE ALVES FORTUNATO
DO CARMO, LEONARDO CAMILO DE OLIVEIRA, CAMILA RODRIGUES CHAVES
NOGUEIRA, JULIANA PRISCILA VAGO DA SILVA, LUIZA OLIVEIRA PERUCCI, BRUNO
DOS SANTOS ALVES FIQUEIREDO BRASIL, CLÁUDIO ANTÔNIO BONJARDIM, MAURO
MARTINS TEIXEIRA, LIRLÂNDIA PIRES DE SOUSA
I-3
EVALUATION OF RECOMBINANT CXCL12(5-67) CHEMOTACTIC
ACTIVITY ON CXCR4+ CELLS IN VITRO TAÍS ADELITA DE ALMEIDA BARROS,
ROBERTA SESSA STILHANO, SANG WON HAN, GISELLE ZENKER JUSTO, MARIMÉLIA
PORCIONATTO
I-4
CHONDROITIN SULFATE IMPAIRS NEURAL STEM CELL MIGRATION
IN VITRO LAYLA TESTA GALINDO, PIERO BAGNARESI, MARINILCE FAGUNDES DOS
SANTOS, MARIMÉLIA APARECIDA PORCIONATTO
I-5
HEAT STRESS INFLUENCES ON IMMUNE PARAMETERS IN TROPICAL
SEA URCHIN LYTECHINUS VARIEGATUS PAOLA CRISTINA BRANCO, MAÍRA
ESTANISLAU SOARES DE ALMEIDA, RENATA STECCA IUNES, MARINILCE FAGUNDES
DOS SANTOS, JOÃO CARLOS SHIMADA BORGES, JOSÉ ROBERTO MACHADO CUNHA
DA SILVA
I-6
IMMUNE SYSTEM CELLS OF THE RAT VENTRAL PROSTATE
QUANTIFICATION BY HEALTHY, CASTRATED AND ESTROGENIZED ANIMALS
JULIETE APARECIDA FRANCISCO DA SILVA, DAGMAR RUTH STACH-MACHADO,
HERNANDES FAUSTINO DE CARVALHO
I-7
THE ENDOPLASMIC RETICULUM CHAPERONE PROTEIN DISULFIDE
ISOMERASE (PDI) IS REQUIRED FOR PDGF-INDUCED RHOGTPASE ACTIVATION
AND NOX1 NADPH OXIDASE-DEPENDENT VASCULAR SMOOTH MUSCLE CELL
MIGRATION LUCIANA PESCATORE ALVES, DIEGO BONATTO, FABIO LUIS FORTI,
AMINE SADOK, HERVÉ KOVACIC, FRANCISCO RAFAEL MARTINS LAURINDO
I-8
LTB4 AS CHEMOATTRACTANT FACTOR IN THE REGULATORY T
CELLS MIGRATION CYNTIA PECLI E SILVA, RAPHAEL MOLINARO, MARC PETERSGOLDEN, STEVEN L. KUNKEL, CLAUDIO CANETTI, CLAUDIA FARIAS BENJAMIM
I-9
HYPERGLYCEMIA IMPAIRS 2-D AND 3-D MIGRATION OF SKIN
FIBROBLASTS, ALSO AFFECTING CELL ADHESION AND INTEGRINS SURFACE
DISTRIBUTION MAÍRA ESTANISLAU SOARES DE ALMEIDA, KELLY SALZMANN
MONTEIRO, SANDRA COCCUZZO SAMPAIO VERSSONI, TÁRCIO TEODORO BRAGA,
NIELS OLSEN SARAIVA CÂMARA, MARCELO LAZZARON LAMERS, MARINILCE
FAGUNDES DOS SANTOS
I - 10
CHARACTERIZATION OF THE IMPAIRED WOUND HEALING IN THE
DERMIS OF DIABETIC MICE JULIANA DA COSTA FLORIM, ANA FLÁVIA MARÇAL
PESSOA, KAIO FERNANDO VITZEL, HOSANA GOMES RODRIGUES, RUI CURI,
MARCELO LAZZARON LAMERS, MARINILCE FAGUNDES DOS SANTOS
I - 11
ROLE OF LAMININ IN ALLOREACTIVE T-CELL MIGRATION DURING
ACUTE REJECTION ARIANY OLIVEIRA SANTOS, WILSON SAVINO, INGO RIEDERER
I - 12
IMMATURE THYMOCYTES ARE RELEASED INTO THE PERIPHERY OF
TRYPANOSOMA CRUZI ACUTELY INFECTED MICE BY A S1P-DEPENDENT
MECHANISM AILIN LEPLETIER, LILIANE SILVA DE ALMEIDA, NAIARA MARAN,
MARCELO EINICKER LAMA, ANA ROSA PÉREZ, ALIRIO MELENDES, WILSON SAVINO,
ALEXANDRE MORROT LIMA
I - 13
IMMUNOENDOCRINE INTERACTIONS DURING LYMPHOCYTE
MIGRATION IN HUMAN CHAGAS DISEASE LUIZ RICARDO BERBERT, ANA ROSA
PÉREZ, OSCAR BOTTASSO, WILSON SAVINO
J – Cell Signaling
J1-J48
J-1
OUTSIDE-IN SIGNALING BY VE-CADHERIN PROMOTES LOCAL RAC
ACTIVATION AND ENHANCEMENT OF LUNG ENDOTHELIAL BARRIER BY ILOPROST
XINYONG TIAN, OLEKSII DUBROVSKYI, YUFENG TIAN, NOUREDDINE ZEBDA,
NICOLENE SARICH, ANNA BIRUKOVA
J-2
ASSOCIATION BETWEEN ADHERENS JUNCTIONS AND TIGHT
JUNCTIONS VIA RAP1-AFADIN IS REQUIRED FOR PROTECTIVE EFFECTS OF
OXIDIZED PHOSPHOLIPIDS NOUREDDINE ZEBDA, PANFENG FU, VALERY POROYKO,
IVAN COKIC, KONSTANTIN BIRUKOV
J-3
PROTEOMIC ANALYSIS OF SNAKE VENOM GLAND ACTIVATION
AND VENOM PRODUCTION MILENE SCHMIDT LUNA, RICHARD HEMMI VALENTE,
JONAS PERALES, MONICA LARUCCI VIEIRA, NORMA YAMANOUYE
J-4
KNOCKDOWN OF ARHGAP21 MODULATES THE EXPRESSION OF
GENES RELATED TO HYPOXIA AND GLYCOLYSIS IN ADENOCARCINOMA PROSTATE
CELL LINES MARIANA LAZARINI, MARCOS MARANGONI, JOÃO AGOSTINHO
MACHADO NETO, PATRICIA SEVEVERINO, CARLOS ALBERTO MOREIRA-FILHO,
FABÍOLA TRAINA, SARA TERESINHA OLALLA SAAD
J-5
SUB-CELLULAR LOCALIZATION OF NEK7 AND ITS INTERACTION
PROTEINS EDMÁRCIA ELISA DE SOUZA, GABRIELA VAZ MEIRELLES, BÁRBARA
BIATRIZ GODOY, EDUARDO CRUZ MORAES, JULIANA HELENA COSTA SMETANA,
JÖRG KOBARG
J-6
FLOTILLINS STABILIZE CADHERIN COMPLEXES AT CELL-CELL
CONTACTS THROUGH INTERACTION WITH THE F-ACTIN CYTOSKELETON EMILIE
GUILLAUME, FRANCK COMUNALE, STÉPHANE BODIN, CÉCILE GAUTHIER-ROUVIÈRE
108
J-7
SYMPATHETIC OUTFLOW ON PROTEIN EXPRESSION IN THE MOUSE
PAROTID GLAND CÍNTIA SCUCUGLIA HELUANY, MILENE SCHIMIDT LUNA, NORMA
YAMANOUYE
J-8
FUNCTIONAL CHARACTERIZATION CELL CYCLE REGULATING
KINASE NEK7 AND ITS INTERACTION PROTEINS BÁRBARA BIATRIZ DE GODOY,
EDMÁRCIA ELISA SOUZA, SMETANA, J.H.C., JÖRG KOBARG
J-9
INTEGRATION OF MULTIPLE SIGNALING ROUTES IN T CELLS CAN
CONTROL GENERATION AND SURVIVAL OF LONG-LIVED ANTIBODY-SECRETING
CELLS LIDIANE ZITO GRUND, MÔNICA LOPES FERREIRA, CARLA LIMA
J - 10
PKC AND CALCIUM BUT NOT PLC ARE INTRACELLULAR
MESSENGERS OF VASOCONSTRICTOR RESPONSE INDUCED BY ANGIOTENSIN II IN
THE SNAKE CROTALUS DURISSUS TERRIFICUS MÉLANIE MRQ LE DIAGON, MARIA
CRISTINA BRENO
J - 11
CELLULAR DISTRIBUTION OF ADHESION MOLECULES (CAMS) IN
PANCREATIC ISLETS OF OBESE AND PRE-DIABETIC MICE. VIVIANE TANNURI
FERREIRA LIMA FALCAO, DANIELA APARECIDA MASCHIO, LUÍZA MARTINEZ
PERDIGUEIRO, JUNIA CAROLINA REBELO DOS SANTOS SILVA, MARIANNE R
SANTOS, CAROLINA P.F. CARVALHO, MARIA TEREZA CARTAXO, CARLA BEATRIZ
COLLARES BUZATO
J - 12
SPATIAL REGULATION OF RAS SIGNALLING NETWORKS VERONICA
ARAN, IAN PRIOR
J - 13
FLUOXETINE ATTENUATED TREK-2-MEDIATED APOPTOTIC CELL
DEATH IN HEK293A CELLS KEE RYEON KANG, CHEOL SOON LEE
J - 14
BRAIN CAMP/CA2+ SIGNALING GENES IN FAT TISSUE IMPLANTED
POLYCYSTIC OVARIAN SYNDROME MOUSE JORGE KEDE, EDUARDO HENRIQUE DA
SILVA FREITAS, CARLOS FERNANDES BATISTA, MARIA DE NAZARETH GAMBOA
RITTO, ISIDORO BINDA NETO, SAMUEL MARCOS RIBEIRO DE NORONHA, SILVANA
APARECIDA ALVES CORRÊA DE NORONHA, ISMAEL DALE COTRIM GUEREIRO DA
SILVA
J - 15
TYROSINE PHOSPHORYLATION PLAYS A ROLE IN INCREASING
MASPIN PROTEIN LEVELS AND ITS CYTOPLASMIC ACCUMULATION MARIANA
TAMAZATO LONGHI, NATHALIE CELLA
J - 16
NADPH OXIDASE ACTIVATION MEDIATED BY PROTEIN DISULFIDE
ISOMERASE OVEREXPRESSION IN VSMC: ROLE OF ANGIOTENSIN II RECEPTOR
(AT1R) RENATA DE CASTRO GONÇALVES, FRANCISCO RAFAEL MARTINS
LAURINDO, DENISE DE CASTRO FERNANDES
J - 17
TXNIP IS RESPONSIBLE FOR IMPAIRED GLUCOSE TOLERANCE IN
THE DIABETIC MICE JO SEONG-HO, PARK JOO-MAN, KIM MI-YOUNG, KIM TAEHYUN, AHN YONG-HO
J - 18
PALMITATE INDUCES INTRACELLULAR CALCIUM (CA2+)
MOBILIZATION IN MONONUCLEAR CELLS FROM TYPE 2 DIABETIC PATIENTS
CAROLINE MARIA DE OLIVEIRA VOLPE, FERNANDA SARMENTO FAGUNDES-NETTO,
RAQUEL MIRANDA GONZAGA, POLLYANNA STEPHANIE GOMES, JOSÉ AUGUSTO
NOGUEIRA-MACHADO
J - 19
TIMP1/ Β1-INTEGRIN/CD63 COMPLEX: RESISTANCE TO ANOIKIS
ALONG MELANOCYTE MALIGNANT TRANSFORMATION BY PI3-K/AKT SIGNALING
PATHWAY MARIANA TORICELLI PINTO, FABIANA HENRIQUES MACHADO DE
MELO, MIRIAM GALVONAS JASIULIONIS
J - 20
ACTIVATION OF RAC1 THROUGH A FAK-INDEPENDENT PATHWAY
IN INHIBITION OF MIGRATION MEDIATED BY RECK GENE IN HUMAN GLIOMA
RAQUEL BRANDÃO HAGA, FERNANDA LEVE, JOSÉ ANDRÉ MORGADO-DIAZ, SILVYA
STUCHI MARIA-ENGLER
J - 21
SUMOYLATION OF THE HUMAN REGULATORY PROTEIN KI-1/57
AND ITS FUNCTION IN THE CELL ÂNGELA SAITO, KALIANDRA DE ALMEIDA
GONÇALVES, MARCOS TADEU DOS SANTOS, JÖRG KOBARG
RODRIGUES, FABIO DUPART NASCIMENTO, EDGAR JEAN PAREDES GAMERO,
IVARNE LUIS DOS SANTOS TERSARIOL, HELENA BONCIANI NADER
J - 27
CHARACTERIZATION OF MASPIN SUMOYLATION CRISTIANE LUMI
HIRATA, NATHALIE CELLA
J - 28
PROTEIN KINASE B (PKB, AKT) IS INVOLVED IN RHIPICEPLAHUS
(BOOPHILUS) MICROPLUS EMBRYO CELL LINE BME26 SURVIVAL LEONARDO
ARAUJO DE ABREU, CHRISTIANO CALIXTO DA CONCEIÇÃO, SATORU KONNAI,
KASUHIRO OHASHI, ITABAJARA DA SILVA VAZ JR, CARLOS JORGE LOGULLO DE
OLIVEIRA
J - 29
A POSSIBLE INTERPLAY BETWEEN RELAXIN AND FSH TO REGULATE
SERTOLI CELL FUNCTION. ALINE ROSA DO NASCIMENTO, THAÍS FABIANA
GAMEIRO LUCAS, CATARINA SEGRETI PORTO, MARIA FÁTIMA MAGALHÃES LAZARI
J - 30
PS-1/GAMMA-SECRETASE-DEPENDENT CADHERIN CLEAVAGE
REGULATES OSTEOGENIC DIFFERENTIATION OF HUMAN BONE MARROW
MESENCHYMAL STROMAL CELLS BY CONTROLLING THE TRANSLOCATION OF THE
ACTIVE SIGNALING FORM OF BETA-CATENIN TO NUCLEUS DANIELLE CABRAL
BONFIM, RHAYRA BRAGA DIAS, CLAUDIA DOS SANTOS MERMELSTEIN, MARIA
ISABEL DORIA ROSSI
J - 31
NITRIC OXIDE AMELIORATES THE OXIDATIVE STRESS INDUCED BY
ARSENIC IN WATER HYACINTH HELOÍSA MONTEIRO DE ANDRADE, JURACI ALVES
DE OLIVEIRA, JOSÉ LINO NETO, JOSÉ CAMBRAIA, FERNANDA DOS SANTOS
FARNESE, CRISTIANE JOVELINA DA SILVA
J - 32
DOES NITRIC OXIDE ACTIVATE ANTIOXIDATIVE ENZYMES IN
PLANTS EXPOSED TO ARSENIC? JURACI ALVES DE OLIVEIRA, HELOÍSA MONTEIRO
DE ANDRADE, JOSÉ LINO NETO, JOSÉ CAMBRAIA, FERNANDA DOS SANTOS
FARNESE
J - 33
MODULATION OF NADPH OXIDASE BY PROTEOGLYCANS IN CHOK1 AND CHO-745 CELLS. SHEYLA VARELA LUCENA, GISELLE ZENKER JUSTO, ZAIANE
MENESES CAMILO, TIAGO RODRIGUES, DAYSE CAROLINE SEVERIANO DA CUNHA,
HELENA BONCIANI NADER, IVARNE LUIS DOS SANTOS TERSARIOL
J - 34
CHARACTERIZATION OF EPITHELIAL CELL SIGNALLING DURING
CANDIDA ALBICANS AND NON-ALBICANS INVASION BY INDUCED ENDOCYTOSIS
DIANA BAHIA, ALEXIS BONFIM-MELO, PALOMA KOREHISA MAZA, RENATO
ARRUDA MORTARA, ARNALDO COLOMBO, ANA CAROLINA BARBOSA PADOVAN,
ERIKA SUZUKI, RICARDO SÉRGIO COUTO DE ALMEIDA
J - 35
SIGNALING PATHWAYS ASSOCIATED WITH NEUTROPHIL
EXTRACELLULAR TRAPS (NETS) FORMATION BY NEUTROPHILS STIMULATED
WITH LEISHMANIA AMAZONENSIS THIAGO SOARES DE SOUZA VIEIRA, ANDERSON
GUIMARÃES BAPTISTA COSTA, MICHELLE TANNY CUNHA DO NASCIMENTO,
RAFAEL MARIANTE, ELVIRA MARIA SARAIVA
J - 36
EXPRESSION PROFILE ASSESSMENT OF NUCLEAR RECEPTORS AND
CO-REGULATORS GENES IN BREAST CANCER CELL SK-BR3 AFTER HCG,
ANGIOTENSIN 1-7 AND ESTRADIOL TREATMENTS ISIDORO BINDA NETO, WERICA
BERNARDO, GABRIELA SOARES BRITO, ADRIANA CARVALHO, JORGE KEDE,
EDUARDO HENRIQUE DA SILVA FREITAS, CARLOS FERNANDES BATISTA, MARIA DE
NAZARETH GAMBOA RITTO, SAMUEL MARCOS RIBEIRO DE NORONHA, SILVANA
APARECIDA ALVES CORRÊA DE NORONHA, GIL FACINA, ISMAEL DALE COTRIM
GUERREIRO DA SILVA
J - 37
COMPARTMENTALIZATION OF REDOX PROCESSES, NOX4 AND
ENDOPLASMIC RETICULUM CHAPERONES WITHIN LIPID DROPLETS IN VASCULAR
SMOOTH MUSCLE CELLS. THALITA BALSAMO ABRAHAO, ANGELICA A AMANSO,
VICTOR DEBBAS, PATRICIA T BOZZA, EDLAINE LINARES, OHARA AUGUSTO,
BERNARD LASSEGUE, KATHY K GRIENDLING, FRANCISCO RM LAURINDO
J - 38
IS TRYPANOSOMA CRUZI P21 A CHEMOKINE-LIKE PROTEIN? ADELE
AUD RODRIGUES, TATIANA MORDENTE CLEMENTE1, FABRÍCIO CASTRO
MACHADO, PAULO CÉSAR FERREIRA DOS SANTOS, FERNANDO DE QUEIRÓZ
CUNHA, TIAGO WILSON PATRIARCA MINEO, CLAUDIO VIEIRA DA SILVA
J - 22
REGULATION OF WILSON DISEASE ATPASE (ATP7B) ACTIVITY LUIZA
HELENA DALTRO CARDOSO, ELAINE HILARIO DE SOUZA, ADALBERTO VIEYRA,
JENNIFER LOWE
J - 39
EARLY
WEANING-STIMULATED
PROLIFERATION
AND
DIFFERENTIATION IN THE GASTRIC MUCOSA: ARE MAPK OR SRC SIGNALING
PATHWAYS INVOLVED? LUCIANA HARUMI OSAKI, CRUZ ALBERTO MENDOZA
RIGONATI, PATRÍCIA GAMA
J - 23
MODULATION OF TRL2 AND TLR4 ACTIVATION BY MAPK
INHIBITOR :EVALUATION OF ROS PRODUCTION BY PBMNC FORM TYP2 DIABETIC
PATIENTS. FERNANDA SARMENTO FAGUNDES NETTO, CAROLINE MARIA OLIVEIRA
VOLPE, RAQUEL MIRANDA GONZAGA, POLLYANNA STEPHANIE GOMES, JOSÉ
AUGUSTO NOGUEIRA-MACHADO
J - 40
THIOREDOXIN-1 INTERACTS WITH ADAM17 AND MODULATES ITS
HB-EGF SHEDDASE IN A P38 AND ERK1/2-INDEPENDENT PATHWAYS ANNELIZE Z
B ARAGAO, DANIELA C GRANATO, MARIA LUIZA C NOGUEIRA, FERNANDO M
SIMABUCO, ANA C M ZERI, ADRIANA F PAES LEME
J - 24
TRANSITION TO WIDESPREAD VASCULAR CELL LOSS DUE TO
SUSTAINED ENDOPLASMIC RETICULUM STRESS IS MARKED BY INCREASED
OXIDANT GENERATION, BUT OXIDANTS DO NOT INDUCE CELL DEATH JOÃO
WOSNIAK JÚNIOR, PHELIPE MONTEIRO FELÍCIO, NATHÁLIA ARAÚJO, FRANCISCO
RAFAEL MARTINS LAURINDO
J - 25
FGFS/FGFRS SIGNALING IN HUMAN KERATINOCYTES EDUARDO
LOPES DA SILVA, JULIANA DIAS ZEIDLER, ANDRE ZELANI, SOLANGE M T SERRANO,
HUGO AGUIRRE ARMELIN
J - 26
MODULATION OF P2X7 RECEPTORS BY GLYCOSAMINOGLYCANS
(GAG) GIOCONDA EMANUELLA DINIZ DE DANTAS MOURA, RAFAEL LIMA CASAES
J - 41
INVOLVEMENT OF PROTEIN KINASE C AND PHOSPHOLIPASE C IN
THE ACTIVATION OF CLOCK GENES BY BLUE LIGHT MARIA NATHÁLIA DE
CARVALHO MAGALHÃES MORAES, BRUNO C. R. RAMOS, LEONARDO HENRIQUE R
G LIMA, ANA MARIA DE LAURO CASTRUCCI
J - 42
ACTIVATION OF THE ASCORBATE-GLUTATHIONE CYCLE BY NITRIC
OXIDE: SIGNALING UNDER STRESS CONDITIONS TRIGGERED BY ARSENIC
FERNANDA SANTOS FARNESE, JURACI ALVES DE OLIVEIRA, LUHAN ISAAC SIMAN,
NEIDIQUELE MARIA DA SILVEIRA, GRASIELLE SOARES GUSMAN
J - 43
RESTORATION OF LEPTIN RECEPTORS IN POMC NEURONS IN
DB/DB MICE AND ROLE OF LIVER IN MAINTAINING THE GLUCOSE HOMEOSTASIS
109
MARIANA SARTO FIGUEIREDO, ALAN VICENTE FERREIRA, PATRICIA CRISTINA
LISBOA, ELAINE DE OLIVEIRA, CHRISTIAN BJORBAEK, EGBERTO GASPAR DE MOURA
ALMEIDA, ANA LUCIA ABUJAMRA, ALGEMIR LUNARDI BRUNETTO, GILBERTO
SCHWARTSMANN, RAFAEL ROESLER
J - 44
INVESTIGATION OF THE MECHANISM OF MOLECULAR
INTERACTION BETWEEN THE N-TYPE CALCIUM CHANNELS AND G PROTEINS
LUCIENE BRUNO VIEIRA, LUARA AUGUSTA BATISTA, MARCUS VINÍCIUS GOMEZ,
GERALD WERNER ZAMPONI
K - 11
EVALUATION OF THE WHOLE BONE MARROW INFLUENCE ON THE
INNATE IMMUNITY IN A MODEL OF ACUTE LIVER FAILURE CAROLINA URIBE
CRUZ, CARLOS OSCAR KIELING, MÓNICA LUJÁN LÓPEZ, LAURA SIMON, GUSTAVO
OCH MUÑOZ, LUISE MEURER, URSULA MATTE
J - 45
LIMITED
PROTEOLYSIS
BY
CALPAIN
A
REGULATES
CACTUS/IKAPPAB FUNCTION AND DORSAL-VENTRAL PATTERNING IN THE
DROSOPHILA EMBRYO HELENA ARAUJO, MARCIO FONTENELE, GERTHRUD
SCHUPBACH
K - 12
PLATELET IMPROVES SURVIVAL IN A RAT MODEL OF ACUTE LIVER
FAILURE LAURA SIMON, MÓNICA LUJAN LÓPEZ, ALESSANDRO OSVALDT,
CAROLINA URIBE CRUZ, CARLOS OSCAR KIELING, GUSTAVO OCHS DE MUÑOZ,
LUISE MEURER, URSULA MATTE
J - 46
NOVEL MODULATORS OF WNT/BETA-CATENIN PATHWAY
THROUGH FUNCTIONAL SCREENING OF NATURAL COMPOUNDS BÁRBARA DE
FARIA DA FONSECA, DÉBORA MALTA CERQUEIRA, NATHÁLIA DA GRAÇA AMADO,
RICARDO KUSTER, JOSÉ GARCIA ABREU JR
K - 13
CELL THERAPY FOR ACUTE LIVER FAILURE: EXPERIMENTAL STUDY
WITH MICROENCAPSULATED CELLS LAURA SIMON, CARLOS OSCAR KIELING,
CAROLINA URIBE CRUZ, MÓNICA LUJAN LÓPEZ, ALESSANDRO OSVALDT, GUSTAVO
OCHS DE MUÑOZ, LUISE MEURER, URSULA MATTE
J - 47
P2X7 RECEPTOR MEDIATES APOPTOSIS IN EPITHELIAL CELLS HCT8
VIA REACTIVE OXYGEN SPECIES VANESSA RIBEIRO FIGLIUOLO, HAYANDRA
FERREIRA NANINI, ALESSANDRA ALVES ABALO, GIANI FRANÇA SANTORO, CLÁUDIA
MARA LARA MELO COUTINHO, ROBSON COUTINHO SILVA
K - 14
PRODUCTION
OF
RECOMBINANT
HUMAN
VASCULAR
ENDOTHELIAL GROWTH FACTORS IN MAMMALIAN EXPRESSION SYSTEMS FOR
ANGIOGENESIS AND WOUND HEALING ANA CLAUDIA OLIVEIRA CARREIRA,
GUSTAVO GROSS BELCHIOR, FERNANDA CÂMARA MARQUES SODRÉ, THERI LEICA
THEGAKI, RAQUEL SANTANA CRUZ, MARI CLEIDE SOGAYAR
J - 48
MESENTERIAL FAT UPR AND TLR4 ACTIVATION MARKERS WERE
ASSOCIATED WITH OBESOGENIC GUT MICROBIOTA CARLA EVELYN COIMBRA
NUÑEZ, VIVIANE SOARES RODRIGUES, MURILLO LINO BUTION, RAFAEL DE
MORAES PEDRO, MÁRCIO JOSÉ DA SILVA, ÉRIKA ANNE ROBLES ROMAN, DANIELE
CRISTINA VITORINO, WANDERLEY DIAS DA SILVEIRA, ELIANA PEREIRA DE ARAÚJO
K – Cell Therapy
K - 15
THE PRE-CONDITIONING WITH BRADYKININ-POTENTIATING
PEPTIDES DERIVED FROM BOTHROPS JARARACA SNAKE VENOM INCREASES THE
THERAPEUTIC EFFECT OF ANGIOGENIC STEM CELLS IN A HINDLIMB ISCHEMIA
MODEL ALAN SALES BARBOSA, BRÍGIDA GOMES DE ALMEIDA SCHIMER, MARIA
CECÍLIA CAMPOS CANESSO, JOUSIE MICHEL PEREIRA, DANIELLE ALVES IANZER,
ANTÔNIO CARLOS MARTINS DE CAMARGO, PATRÍCIA GONÇALVES TEIXEIRA,
ANTÔNIO CARLOS VIEIRA CABRAL, MAURO MARTINS TEIXEIRA, LUCÍOLA DA SILVA
BARCELOS
K1-K16
K - 16
BONE MARROW MONONUCLEAR CELL THERAPY REDUCES
REACTIVE MICROGLIOSIS AND HIPPOCAMPAL CA1 PYRAMIDAL CELL DEATH
FOLLOWING GLOBAL CEREBRAL ISCHEMIA IN RATS. ALANE BERNARDO RAMOS,
ANDRÉIA VASCONCELOS- DOS-SANTOS, WAGNER MONTEIRO CINTRA, ROSALIA
MENDEZ-OTERO
K-1
HEPATIC CELLS: AN ALTERNATIVE SOURCE TO REPOPULATE THE
BIO-ARTIFICIAL LIVER LANUZA ALABY PINHEIRO FACCIOLI, GRAZIELLE SUHETT
DIAS, LUIZ FERNANDO QUINTANILHA, SANDRO TORRENTES CUNHA, BERNARDO
JORGE DA SILVA MENDES, RACHEL RACHID, MARCIA ATTIAS, CHRISTINA MAEDA
TAKIYA, ADRIANA BASTOS CARVALHO, REGINA COELI DOS SANTOS GOLDENBERG
L – Cells as Biosensors
K-2
BONE MARROW CELLS DERIVED-FIBROBLAST GROWTH FACTOR-2
INDUCES GLIAL CELL PROLIFERATION IN THE REGENERATING PERIPHERAL
NERVOUS SYSTEM ALVARO CARRIER RUIZ, ROBERTHA MARIANA RODRIGUES
LEMES, RICARDO AUGUSTO DE MELO REIS, ROSALIA MENDEZ-OTERO, VICTOR
TÚLIO RIBEIRO RESENDE
K-3
IDENTIFICATION OF CARDIOMYOCYTES TRANSDIFFERENTIATED
FROM ADIPOSE DERIVED MESENCHYMAL STEM CELLS BIANCA FERRARINI
ZANETTI, SANG WON HAN
K-4
MONONUCLEAR CELLS FROM HUMAN UMBILICAL CORD BLOOD
PROMOTES FUNCTIONAL RECOVERY AFTER SPINAL CORD INJURY IN RATS
LUCIANO PALMEIRO RODRIGUES, DAIKELLY IGLESIAS BRAGHIROLLI, FABRÍCIO DO
COUTO NICOLA, DANIELA STEFFENS, LAUREN VALENTIM, ALESSANDRO WITCZAK,
GEANCARLO ZANATTA, MATILDE ACHAVAL, PATRICIA PRANKE, CARLOS
ALEXANDRE NETTO
K-5
RETINAL SPHERES SIMILAR STRUCUTURES-DERIVED FROM DENTAL
PULP STEM CELLS ARE POSITIVE FOR PAX-6 MARKER BRUNA PEREIRA DE MORAIS,
LISLEY INATA MAMBELLI, NELSON FORESTO LIZIER, BABYLA GERALDES MONTEIRO,
JOSÉ ÁLVARO PEREIRA GOMES, IRINA KERKIS
K-6
INTERNALIZATION
ASSAY
OF
POLY-Ε-CAPROLACTONE
NANOPARTICLES USING PERITONEAL MACROPHAGES: THE ACTION OF FREE OR
NANOENCAPSULATED ZINC (II) PHTALOCYANINE AMANDA SANTOS FRANCO DA
SILVA, EDUARDO RICCI JUNIOR, MORGANA TEIXEIRA LIMA CASTELO BRANCO,
LYCIA DE BRITO GITIRANA
K-7
INSULIN COATING IN HIDROXYAPATITE INCREASES OSTEOBLASTIC
CELLS ATTACHMENT MOEMA A HAUSEN, ELENA MAVROPOULOS, JÉSSICA
DORNELAS, SUZANA DOS ANJOS, ALEXANDRE ROSSI
K-8
RADIATION-INDUCED LIVER DAMAGE IN MICE: AN EXPERIMENTAL
MODEL TO STUDY TISSUE REGENERATION GRAZIELLESUHETT DIAS, LANUZA
ALABY FACCIOLI PINHEIRO, SANDRO TORRENTES CUNHA, TIAGO SOUZA VILASBÔAS, ALYNE HENRIQUES CORDEIRO, LUIZ FERNANDO QUINTANILHA, BRUNO
DIAZ PAREDES, CRISTINA MAEDA TAKIYA, PAULO CÉSAR CANARY, ADRIANA
BASTOS CARVALHO, REGINA COELI GOLDENBERG SANTOS
L1-L7
L-1
ENVIRONMENTAL ASSESSMENT USING MUCOUS CELLS OF SCALE
EPITHELIUM IN FISH REBECA MAMEDE DA SILVA ALVES, JOSÉ AUGUSTO
SENHORINI, RITA DE CÁSSIA GIMENEZ DE ALCÂNTARA ROCHA, BRUNO FIORELINI
PEREIRA, FLÁVIO HENRIQUE CAETANO
L-2
CYTOMORPHOLOGICAL CHANGES IN THE ARMORED CATFISH
LORICARICHTHYSANUS, IN THE SINOS RIVER (RIO GRANDE DO SUL, BRAZIL),
DURING AN EPISODE OF FISH MORTALITY AND CORRELATION WITH THE
PRESENCE OF HERBICIDES CARLOS AUGUSTO BORBA MEYER NORMANN, KARINA
JOB DI LACCIO, MILENE SANTANA PINTO, VALESCA VEIGA CARDOSO CASALI
L-3
ABCB1 AND ABCC1 PROTEINS ACTIVITY IN COELOMOCYTES OF THE
SEA URCHIN ECHINOMETRA LUCUNTER. LEONARDO LIMA DOS SANTOS, PATRICIA
MIRELLA DA SILVA SCARDUA, LUIS FERNANDO MARQUES DOS SANTOS
L-4
EFFECTS OF CHRONIC USE OF GRAPE JUICE ON HEPATOCYTES OF
WISTAR RATS IN HIGH-FAT DIET CARLOS AUGUSTO BORBA MEYER NORMANN,
ISELDE BUCHNER, NIARA MEDEIROS, DENISE LACERDA, PAULA RIGON, JOÃO
ANTÔNIO HENRIQUES, ROSANE GOMEZ, CAROLINE DANI, CLAUDIA FUNCHAL
L-5
BIOMARKERS OF LEPROSY: NEUTROPHIL CD64 EXPRESSION AS A
BIOMARKER OF ERYTHEMA NODOSUM LEPROSUM VERÔNICA SCHMITZ PEREIRA,
RHANA BERTO PRATA, SHEILA SANTOS BRANDÃO, MAYARA ABUD MENDES, ALICE
MIRANDA, JOSÉ AUGUSTO NERY, EUZENIR NUNES SARNO
L-6
IMMUNOFLUORESCENCE OF THE MUSHROOM BODIES OF
STINGLESS BEES, SCAPTOTRIGONA POSTICA (LATREILLE, 1807), TREATED WITH
IMIDACLOPRID BY INGESTION HELLEN MARIA SOARES, ROBERTA CORNÉLIO
FERREIRA NOCELLI, CYNTHIA RENATA DE OLIVEIRA JACOB, OSMAR MALASPINA
L-7
EVALUATION OF THE TOXICITY ON STINGLESS BEE
SCAPTOTRIGONA POSTICA (HYMENOPTERA, APIDAE MELIPONINI) MUSHROOM
BODIES, TREATED WITH SUBLETHAL DOSES OF FIPRONIL CYNTHIA RENATA DE
OLIVEIRA JACOB, HELLEN MARIA SOARES, ROBERTA CORNÉLIO FERREIRA NOCELLI,
OSMAR MALASPINA
K-9
REPAIR OF SKIN DAMAGE WITH ADIPOSE-DERIVED STEM CELLS
USING SODIUM CARBOXYMETHYLCELLULOSE SCAFFOLD IN RATS CRISTIANO
RODRIGUES, ELISA VASCONCELLOS SOARES, ADRIANO MARTIMBIANCO DE ASSIS,
MARILDA DA CRUZ FERNANDES, LÉDER LEAL XAVIER, ALEXANDRE TAVARES
DUARTE DE OLIVEIRA, MÁRCIA ROSÂNGELA WINK
K - 10
A GASTRIN-RELEASING PEPTIDE RECEPTOR ANTAGONIST
ENHANCES VIABILITY AND PROLIFERATION OF NEUROBLASTOMA CELLS:
PREVENTION BY A HISTONE DEACETYLASE INHIBITOR VIVIANE RÖSNER DE
110
M – Cytoskeleton
M1-M13
M -1
VISUALIZATION OF CYTOSKELETON OF TRITRICHOMONAS FOETUS
BY FESEM (HIGH RESOLUTION FIELD EMISSION SCANNING ELECTRON
MICROSCOPY) IVONE ROSA DE ANDRADE, WANDERLEY DE SOUZA, MARLENE
BENCHIMOL
M -2
A
SMALL
MOLECULE
TARGETING
CDC42-INTERSECTIN
INTERACTION DISRUPTS GOLGI ORGANIZATION AND SUPPRESSES CELL MOTILITY
AMY FRIESLAND, YAXUE ZHAO, YAN-HUA CHEN, HUCHEN ZHOU, QUN LU
M -3
THE IMMUNOLOCALIZATION OF CYTOSKELETAL PROTEINS AND
THE BASEMENT MEMBRANE MARKER LAMININ IN THE OVIDUCT OF THE
DOMESTIC FOWL (GALLUS DOMESTICUS) MARY CATHRINE MADEKUROZWA
M -4
PROBABLE INVOLVEMENT OF THE RAC1 GTPASE IN
RADIOSENSITIVITY OF HELA CELLS JULIANA HARUMI OSAKI, GISELE ESPINHA
TEIXEIRA DA SILVA, FÁBIO LUIS FORTI
M -5
RHOA GTPASE MEDIATES RECOVERY OF MELANOMA CELLS
DAMAGED BY ULTRAVIOLET RADIATION GISELE ESPINHA TEIXEIRA DA SILVA,
FÁBIO LUÍS FORTI
M -6
PROTEIN INTERACTION DURING ASYMMETRIC CELL DIVISION IN
BACILLUS SUBTILIS MAXWELL DE CASTRO DURVALE, FREDERICO JOSE GUEIROS
FILHO
M -7
REGULATION OF MICROTUBULES DYNAMICS BY DYNAMIN-2 IN
HELA CELLS MAKIKO MORITA, KOZUE HAMAO, KEITA TANAKA, YASUYUKI SERA,
HIROSHI HOSOYA
M -8
PARTICIPATION OF CORTICAL ACTIN FROM NON- AND
PHAGOCYTIC CELLS DURING TOXOPLASMA GONDII INVASION PROCESS BRENO
COSTA LANDIM, SARA HISSAE HIRAIWA, PRISCILA SILVA FRANCO, ELOISA VIEIRA
AMÁLIA FERRO, JULIANA GONZAGA DE OLIVEIRA
M -9
CYTOKERATINS CROSSTALK IN BREAST CANCER THAISE
GONÇALVES DE ARAÚJO, KARINA MARANGONI, YARA CRISTINA DE PAIVA MAIA,
GALBER RODRIGUES ARAÚJO, PATRÍCIA TERRA ALVES, LARISSA PRADO MAIA,
DONIZETE WILLIAM SANTOS, LUANDA CALÁBRIA, CARLOS UEIRA-VIEIRA, LUIZ
RICARDO GOULART FILHO
M -10
STUDYING A PROTEIN-PROTEIN INTERACTION THAT REGULATES
BACTERIAL CELL DIVISION VALDIR BLASIOS JUNIOR, ALEXANDRE WILSON BISSON
FILHO, PATRÍCIA CASTELLEN, RODRIGO PORTUGAL, JEFFERSON BETTINI,
FREDERICO GUEIROS FILHO
M -11
EXPRESSION OF THE CYTOSKELETAL PROTEINS ACTIN AND
TUBULIN IN OSTEOGENIC CELLS CULTURED ON BIOACTIVE GLASS-BASED
SURFACES CAROLINA SCANAVEZ MARTINS, LUCAS NOVAES TEIXEIRA, LARISSA
MOREIRA SPINOLA DE CASTRO, MÁRCIO MATEUS BELOTI, ADALBERTO LUIZ ROSA,
PAULO TAMBASCO DE OLIVEIRA
M -12
MURINE MACROPHAGE CYTOSKELETON ALTERATIONS CAUSED BY
AQUEOUS EXTRACT OBTAINED FROM ROOTS OF PHYSALIS ANGULATA RAQUEL
RAICK PEREIRA DA SILVA, ANA PAULA DRUMMOND RODRIGUES, AMANDA
ANASTÁCIA PINTO HAGE, GILMARA DE NAZARETH TAVARES BASTOS, EDILENE
OLIVEIRA DA SILVA
M -13
MITOCHONDRIA ARE ANCHORED BY ACTIN FILAMENTS TO THE
CORTEX AND ARE MOTILE IN SEA URCHIN EGGS ISSEI MABUCHI, TOMOKO
TAKAGI, SHINYA INOU, MAKOTO GODA
N – Developmental
Biology
N1-N51
N-1
INFLUENCE OF SONIC HEDGEHOG SIGNALLING PATHWAY IN THE
EAR DEVELOPMENT ALICE HELENA DOS REIS RIBEIRO, JOSÉ GARCIA RIBEIRO
ABREU, JOSÉ MARQUES DE BRITO NETO
N-2
ECTODERMAL-DERIVED ENDOTHELIN1 DRIVES DEVELOPMENT OF
THE MOUSE MANDIBULAR ARCH INTERMEDIATE DOMAI
ANDRE
LUIZ PASQUA TAVARES, ELVIN L GARCIA, KATHERIN KUHN, CRYSTAL M WOODS,
TREVOR WILLIAMS, DAVID E. CLOUTHIER
EMBRYONIC DEVELOPMENT APARECIDA DAS DORES TEIXEIRA, MARIA DO CARMO
QUEIROZ FIALHO, JOSÉ COLA ZANUNCIO, JOSÉ EDUARDO SERRÃO
N-4
DEVELOPING A MODEL FOR THE STUDY OF THE HUMAN
MESENCHYMAL STEM CELLS’ POTENCY USING CHICK EMBRYOS INGRID
ROSENBURG CORDEIRO, JOSÉ MARQUES DE BRITO NETO, MARIA ISABEL DORIA
ROSSI
N-5
PIWI PROTEINS AND HISTONE METHYLATION IN THE RAT
PRIMORDIAL GERM CELL DEVELOPMENT RENATO BORGES TESSER, TAIZA
STUMPP
N-6
RAT GONOCYTE QUIESCENCE DEPENDS ON CASPASE 3
EXPRESSION AND OCT4 DOWNREGULATION PRISCILA HENRIQUES DA SILVA,
RENATO BORGES TESSER, CRISTIANE TOBARA MARUYAMA, TAIZA STUMPP
N-7
UVB ENVIRONMENTALLY RELEVANT DOSES INHIBIT EARLY
EMBRYONIC DEVELOPMENT OF SEA URCHIN ECHINOMETRA LUCUNTER.
JOCELMO CÁSSIO DE ARAUJO LEITE, SUELENN GUEDES DA SILVA, JOSÉ PINTO DE
SIQUEIRA JUNIOR, LUIS FERNANDO MARQUES DOS SANTOS
N-8
ABCB1 PROTEIN PROTECTS SEA URCHIN EMBRYONIC
DEVELOPMENT AGAINST UVB INJURIOUS EFFECTS. SUELLEN GUEDES DA SILVA,
JOCELMO CÁSSIO DE ARAUJO LEITE, JOSÉ PINTO DE SIQUEIRA JUNIOR, LUIS
FERNANDO MARQUES-SANTOS
N-9
INVOLVEMENT OF MITOCHONDRIAL PERMEABILITY TRANSITION
PORE (MPTP) AND CALCIUM RELEASING IN FERTILIZED EGGS OF SEA URCHIN.
ELIS TORREZAN GONÇALVES RAMALHO NITÃO, LUIS FERNANDO MARQUESSANTOS
N - 10
PRENATAL GLUCOCORTICOID TREATMENT AFFECTS ERYTHROID
AND MEGAKARYOCYTIC CELLS OF RAT FETUSES AND NEWBORNS FLÁVIA
MACEDO DE OLIVEIRA NEVES, CAMILA CICCONI PACCOLA, SANDRA MIRAGLIA,
IVONE CIPRIANO
N - 11
HDAC ACTIVITY IS NECESSARY FOR THE MORPHOGENESIS OF
POLARIZED TISSUES CARLA AUGUSTA BARRETO MARQUES, ERIKA NEGREIROS,
HELENA ARAUJO, KATIA CARNEIRO, TATHYANA LAMIM
N - 12
CHARACTERIZATION OF ABCB1 AND ABCC1 PROTEINS
FUNCTIONAL ACTIVITY DURING EMBRYONIC DEVELOPMENT OF SEA URCHIN
ECHINOMETRA LUCUNTER ELIS TORREZAN GONÇALVES RAMALHO NITÃO, CAIO
CEZAR OLIVEIRA DE LUCENA, LUIS FERNANDO MARQUES-SANTOS
N - 13
THE SUBCELLULAR DISTRIBUTION OF THE ASYMMETRIC PROTEIN
NODAL IN GLIAL CELLS PLAYS A KEY ROLE DURING DEVELOPMENT AND
PHYSIOPATHOLOGY OF THE CENTRAL NERVOUS SYSTEM MARIA CECÍLIA
OLIVEIRA FERREIRA NUNES, GUILHERME MARQUES DE MATTOS, SUZANA A.
KAHN, FLAVIA LIMA, VIVALDO MOURA-NETO, KATIA CARNEIRO
N - 14
EFFECTS OF TAURINE SUPPLEMENTATION ON ARTERIAL PRESSURE
AND THE NEURONAL NUMBER OF BRAIN STEM IN THE OFFSPRING OF FEMALE
RATS SUBJECTED TO PROTEIN RESTRICTION DURING PREGNANCY JOSE EDUARDO
SCABORA, MARCELO CARDOSO DE LIMA, PATRÍCIA ALINE BOER, JOSE ANTOMIO
ROCHA GONTIJO
N - 15
RGMA EXPRESSION PATTERN IN SKELETAL MUSCLE CELLS IS
SIMILAR TO MYOSINS ALINE FAGUNDES MARTINS, GREGORY THOMAS KITTEN,
GERLUZA APARECIDA BORGES SILVA, DÉBORA CRISTINA INDELICATO DE MIRANDA,
AMANDA VASCONCELOS ALBUQUERQUE, LUIZ LEHMANN COUTINHO, ÉRIKA
CRISTINA JORGE
N - 16
CHARACTERIZATION OF THE PATTERN OF BHC4-1-LACZ
EXPRESSION IN DROSOPHILA LINES TRANSFORMED WITH MUTANT VERSIONS OF
THE BHC4-1 RING GLAND ENHANCER IVANA MARIA DE ARAUJO FURTADO,
MARÍLIA HARUMI ISHIZAWA, NADIA MONESI
N - 17
MORPHOLOGICAL ASSESSMENT OF THE HEART OF THE MOSQUITO
AEDES AEGYPTI DURING THE POST-EMBRYONIC DEVELOPMENT ANA CAROLINA
MACHADO LEÓDIDO, GUSTAVO FERREIRA MARTINS
N - 18
RATART RETROTRANSPOSON INTERFERING IN THE LARVAL
DEVELOPMENT OF RHYNCHOSCIARA AMERICANA PAULA REZENDE-TEIXEIRA,
GLAUCIA MARIA MACHADO-SANTELLI
N - 19
THE ROLE OF THE MATERNAL DPP/BMP PATHWAY ON THE
REGULATION OF RNA LEVELS IN THE EARLY DROSOPHILA MELANOGASTER
EMBRYO. NATHÁLIA PENTAGNA MACIELLO DRUMMOND PIRES, MARCIO RIBEIRO
FONTENELE, HELENA MARIA MARCOLLA ARAÚJO
N - 20
DNA DAMAGE SIGNALING AND REPAIR PATHWAYS IN OCULAR
ORGANOGENESIS PAULO MATHEUS GUERRA RIBEIRO DE SOUSA RODRIGUES,
GABRIEL RODRIGUES CAVALHEIRO, PIERRE-OLIVIER FRAPPART, RODRIGO ALVES
PORTELA MARTINS
N - 21
MORPHOFUNCTIONAL CHARACTERIZATION OF THE PROSTATE IN
CALOMYS CALLOSUS (RODENTIA, CRICETIDAE) RODENT. RENATO SIMÕES
CORDEIRO, KÁRITA ROSA DE ALMEIDA, DANIELE LISBOA RIBEIRO, TATIANA CARLA
TOMIOSSO, MARCELO EMÍLIO BELETTI, LUIZ ROBERTO FALLEIROS JÚNIOR, REJANE
MAIRA GÓES, SEBASTIÃO ROBERTO TABOGA
N-3
DEGENERATION AND CELL REGENERATION IN THE MIDGUT OF
PODISUS NIGRISPINUS (HETEROPTERA: PENTATOMIDAE) DURING THE POST-
111
N - 22
HISTOLOGICAL STUDY OF THE HEMATOPOIETIC ACTIVITY OF THE
MURINE PLACENTA NATHÁLIA AZEVEDO PORTILHO, PRISCILA TAVARES GUEDES,
PEDRO PAULO DE ABREU MANSO, MARCELO PELAJO-MACHADO
N - 23
AGE-RELATED CHANGES IN DNA AMOUNTS OF NEURONAL NUCLEI
FROM MOUSE BRAIN CORTEX. ARE NEURONS POLYPLOID OR ANEUPLOID?
HENRIQUE FERREIRA RODRIGUES, TAFAREL ANDRADE DE SOUZA, FLÁVIA GERELLI
GHIRALDINI, MARCELO EMÍLIO BELETTI, MARIA LUIZA SILVEIRA MELLO, ALBEROT
DA SILVA MORAES
N - 24
KON-TIKI INITIATES FORCE-RESISTANT ATTACHMENT OF
DROSOPHILA FLIGHT MUSCLES TO TENDONS. WEITKUNAT MANUELA, GRILL W.
STEPHAN, SCHNORRER FRANK
N - 25
ANALYSIS OF FGF-8 IN DIDELPHIS ALBIVENTRIS, A PROMISING
EXPERIMENTAL MODEL FOR THE DEVELOPMENTAL BIOLOGY AREA ÍRIA
GABRIELA DIAS DOS SANTOS, ALINE GONÇALVES LIO COPOLA, ERIKA CRISTINA
JORGE, ADRIANA MOREIRA, JOSÉ BENTO ALVES, ALFREDO MIRANDA DE GÓES,
CRISTIANE APARECIDA DE SOUSA, GERLUZA APARECIDA BORGES SILVA
N - 26
ARE CALPAINS INVOLVED IN CACTUS/IKAPPAB DEGRADATION
DURING MUSCLE FORMATION IN DROSOPHILA MELANOGASTER AND CHICK
EMBRYONIC MUSCLES? MÁRCIO AUGUSTO BUFFOLO, HELENA M.MARCOLLA
ARAUJO, CLAUDIA MERMELSTEIN
N - 27
DIFFERENTIAL EFFECTS OF MASTICATORY DEPRIVATION REGIMES
AND REHABILITATION ON THE LOCOMOTOR AND EXPLORATORY ACTIVITIES OF
AGED ALBINO SWISS MICE. DIEGO DE JESUS SILVA, FABÍOLA DE CARVALHO
CHAVES DE SIQUEIRA MENDES, ANDRÉ PINHEIRO GURGEL FELÍCIO, MARINA
NEGRÃO FROTA DE ALMEIDA, MANOELA FALSONI, MARCIA LORENA FERREIRA DE
ANDRADE, JOÃO BENTO TORRES NETO, CRISTOVAM WANDERLEY PICANÇO-DINIZ,
MARCIA CONSENTINO KRONKA SOSTHENES
N - 28
EXPRESSION OF MYC TRANSCRIPTION FACTORS IN DEVELOPING
MOUSE LENS ANIELLE LINS GOMES, GABRIEL RODRIGUES CAVALHEIRO, RODRIGO
ALVES PORTELA MARTINS
N - 29
THE ROLE OF MYOSIN VA IN THE NEURITOGENESIS OF DORSAL
ROOT GANGLIA TRKA-POSITIVE NEURONS TATIANE YUMI NAKAMURA KANNO,
ENILZA MARIA ESPREAFICO, CHAO YUN IRENE YAN
N - 30
CELLULAR
STRESS
INDUCED
BY
UV-RADIATION
ON
MACROBRACHIUM OLFERSI EMBRYOS VALQUIRIA MACHADO CARDOSO, EVELISE
MARIA NAZARI, DIB AMMAR, YARA MARIA RAUH MÜLLER
PEREIRA DIAS DE OLIVEIRA, JORGE JOSÉ DE CARVALHO, MARCELO PELAJO
MACHADO
N - 42
WNT/BETA-CATENIN SIGNALING MODULATION BY MEMBRANE
MICRODOMAINS IN EMBRYONIC DEVELOPMENT ANDRESSA LUY KAJISHIMA,
ALICE HELENA REIS, JOSE GARCIA ABREU
N - 43
REGULATION BETWEEN WNT AND SHH SIGNALING IN FOREBRAIN
DEVELOPMENT FERNANDA PEREIRA DE OLIVEIRA, ALICE HELENA DOS REIS,
ANDRESSA LUY KAJISHIMA, JOSE GARCIA ABREU
N - 44
MORPHOLOGICAL AND HISTOCHEMICAL STUDY OF THE LIVER IN
HEMISORUBIM PLATYRHYNCHOS LARVAE AND ADULT CLAUDEMIR KUHN
FACCIOLI, RENATA ALARI CHEDID, ANTONIO CARLOS DO AMARAL, IRENE BASTOS
FRANCESCHINI VICENTINI, CARLOS ALBERTO VICENTINI
N - 45
GLYCOSYLATION PROCESSES MODULATE BMP PATHWAY DURING
DROSOPHILA MELANOGASTER DEVELOPMENT AMANDA RIBEIRO CÂMARA, ERIKA
MICHELE AVELINO NEGREIROS GONÇALVES, KATIA CARNEIRO DE PAULA, HELENA
MARIA MARCOLLA ARAUJO, ADRIANE REGINA TODESCHINI
N - 46
HOMOCYSTEINE CAUSES DISRUPTIONS ON SPINAL CORD
MORPHOLOGY AND CHANGES THE EXPRESSION OF THE PAX 1/9 AND SOX 9
GENE PRODUCTS IN THE AXIAL MESENCHYME OF THE CHICKEN KAROLINE
KOBUS, GILIAN F. BOURCKHARDT, DIB AMMAR, EVELISE MARIA NAZARI, YARA
MARIA RAUH MÜLLER
N - 47
EARLY DEVELOPMENT OF THE NEOTROPICAL FISH, LEPORINUS
OBTUSIDENS (VALENCIENES, 1836) RENATA ALARI CHEDID, CLAUDEMIR KUHN
FACCIOLI, RICARDO HIDEO MORI, IRENE BASTOS FRANCESCHINI VICENTINI,
CARLOS ALBERTO VICENTINI
N - 48
FUNCTIONAL ANALYSIS OF RHODNIUS PROLIXUS DV PATTERNING
MATEUS ANTONIO BERNI, MÁRCIO RIBEIRO FONTENELE, MARCOS HENRIQUE
FERREIRA SORGINE, RODRIGO NUNES DA FONSECA, HELENA MARIA MARCOLLA
ARAÚJO
N - 49
STRUCTURE OF THE ESOPHAGEAL EPITHELIUM IN HEMISORUBIM
PLATYRHYNCHOS LARVAE AND ADULT CLAUDEMIR KUHN FACCIOLI, RENATA
ALARI CHEDID, ANTONIO CARLOS DO AMARAL, IRENE BASTOS FRANCESCHINI
VICENTINI, CARLOS ALBERTO VICENTINI
N - 50
THE INFLUENCE OF SONIC HEDGEHOG SIGNALLING PATHWAY IN
THE EAR DEVELOPMENT LEONARDO POLON, ALICE HELENA DOS REIS, JOSE
GARCIA RIBEIRO ABREU JUNIOR, JOSÉ MARQUES DE BRITO NETO
N - 31
MORPHOLOGICAL AND GROWTH ANALYSIS OF SKELETAL MUSCLE
IN COLOSSOMA MACROPOMUM (TAMBAQUI) DARUZI CEZAR FELIPPE,
FERNANDA DE MELLO, NÍVIA LOTHHAMMER, LUIS R. J. GUERREIRO, LEANDRO C.
GODOY, DANILO P. STREIT JR
N - 51
MULTIPOTENT
NEURAL
AND
SKELETOGENIC-ADIPOGENIC
PROGENITORS IN THE AVIAN TRUNK NEURAL CREST JULIANA DE MATTOS
COELHO AGUIAR, NICOLE LE DOUARIN, ELISABETH DUPIN
N - 32
104 µM IS THE LOWEST CONCENTRATION OF 20-OH ECDYSONE
THAT STILL INDUCES THE ACTIVITY OF BHSGAMP-1, A GENE THAT ENCODES AN
AMP, IN THE SALIVARY GLAND OF BRADYSIA HYGIDA (DIPTERA, SCIARIDAE)
GABRIELA MORILHA ZANAROTTI, JORGE CURY DE ALMEIDA
O – Epigenetics
N - 33
THE SMAD1 EXPRESSION IN CRANIAL NEURAL CREST CONTROL
FORE- AND MIDBRAIN PATTERNING. DIEGO PINHEIRO AGUIAR, NICOLE LE
DOUARIN
O1-O18
N - 34
EFFECTS OF HOMOCYSTEINE ON MESENCHYMAL CELLS DURING
LIMB DEVELOPMENT OF GALLUS DOMESTICUS EMBRYOS GILIAN FERNANDO
BOURCKHARDT, KAROLINE KOBUS, EVELISE MARIA NAZARI, MANUELA CECCHINI,
YARA MARIA RAUH MÜLLER, DIB AMMAR
O -1
GENETIC AND EPIGENETIC STUDY OF THE GENE TFF1 IN GASTRIC
TUMORS IN PATIENTS OF THE NORTH REGION OF BRAZIL CYNTHIA FARIAS VIEIRA
DE MELO, MARISE LOPES FERMINO, RUBISTENIA MIRANDA SOARES DE ARAÚJO,
TALITTA DANTAS ARRUDA, CACILDA CASARTELLI, ROMMEL RODRÍGUEZ BURBANO,
ELEONIDAS MOURA LIMA
N - 35
MYC PROTO-ONCOGENES REGULATE
GABRIEL RODRIGUES CAVALHEIRO, ANIELLE LINS GOMES
LENS
DEVELOPMENT
N - 36
SALDANA-CABOVERDE A, KOS L (2012). THE TRANSCRIPTION
FACTORS ETS1 AND SOX10 INTERACT DURING MELANOCYTE DEVELOPMENT IN
THE MOUSE EMBRYO. AMY SALDANA-CABOVERDE, LIDIA KOS
N - 37
MEMBRANE METALLOPROTEINASE 1 (MT1-MMP) EXPRESSION IN
THE DEVELOPMENT OF THE INTESTINAL EPITHELIUM OF RATS KAMILA CAROLINE
CAMARGO, MARIA ALBERTINA DE MIRANDA SOARES, JOSÉ ROSA GOMES
N - 38
ULTRAVIOLET B RADIATION (UVB) AFFECTS CELL PROLIFERATION
DURING EARLY EMBRYONIC DEVELOPMENT OF FRESHWATER PRAWN
MACROBRACHIUM OLFERSI. ELIANE CRISTINA ZENI, GUILHERME AUGUSTO MAIA,
FRANCIELY POLLO, DIB AMMAR, YARA MARIA RAUH MÜLLER, EVELISE MARIA
NAZARI
N - 39
EFFECT OF METHYLMERCURY ON EMBRYONIC DEVELOPMENT OF
GALLUS DOMESTICUS FABIANA DE FATIMA FERREIRA, EVELISE MARIA NAZARI,
YARA MARIA RAUH MÜLLER
O -2
METHYLATION PATTERN OF GENE TP53 IN GASTRIC
ADENOCARCINOMA CYNTHIA FARIAS VIEIRA DE MELO, RUBISTENIA MIRANDA
SOARES DE ARAÚJO, TALITTA DANTAS ARRUDA, ELEONIDAS MOURA LIMA
O -3
CPG ISLAND METHYLATION OF CASPASE 8 APOPTOSIS-RELATED
GENE IN HUMAN SAMPLE EPITHELIAL OVARIAN CARCINOMA LETÍCIA DA
CONCEIÇÃO BRAGA, ANA PAULA ÁLVARES DA SILVA RAMOS, AGNALDO LOPES DA
SILVA FILHO, LUCIANA MARIA SILVA
O -4
METHYLATION PROFILE MUTLΑ SUBUNIT OF DNA MISMATCH
REPAIR RUBISTENIA MIRANDA SOARES DE ARAÚJO, CYNTHIA FARIAS VIEIRA DE
MELO, TALITTA DANTAS ARRUDA, ELEONIDAS MOURA LIMA
O -5
DNA METHYLATION RATE AND VITAMINS CONCENTRATIONS IN
WOMEN WITH RECURRENT MISCARRIAGES NATHALIA SIERRA MONTEIRO,
JESSICA CARRILHO BRITTO, KELMA CORDEIRO DA SILVA GIUSTI, MÁRIO HENRIQUE
BURLACCHINI DE CARVALHO, ANTÔNIO AMORIM FILHO, ELVIRA MARIA GUERRA
SHINOHARA
N - 40
CHOLESTEROL SYNTHESIS INHIBITION IN ZEBRAFISH MYOGENESIS
LAISE MONTEIRO CAMPOS, EDUARDO ANDRÉS RÍOS MORRÍS, NAIARA
RODRIGUES, CLÁUDIA DOS SANTOS MERMELSTEIN, MANOEL LUIS COSTA
O -6
STUDY OF UGT1A1 GENE POLYMORPHISMS AND ASSOCIATION
WITH THE ADVERSE EFFECTS IRINOTECAN: A PILOT STUDY HELEN TAIS DA ROSA,
MICHELLE FRAGA EISENHARDT, MARCELO LUIS DOTTO, CÁTIA SEVERO, JULIANA
FONTELLA, LIA POSSUELO
N - 41
CARBOHYDRATE EXPRESSION IN AORTA-GONAD-MESONEPHROS
REGION DURING EARLY CHICK EMBRYO DEVELOPMENT PATRICIA ALZUETA
MORENO MARTINEZ, PRISCILA TAVARES GUEDES, BARBARA CRISTINA EUZEBIO
O -7
IN SITU IDENTIFICATION AND LOCALIZATION OF NUCLEAR
GLYCOPROTEINS IN CORTICAL NEURONS FROM MICE WITH THREE DIFFERENT
AGES TAFAREL ANDRADE DE SOUZA, INGRID CORTIZO PRIETO, HENRIQUE
112
FERREIRA RODRIGUES, FLAVIA GERELLI GHIRALDINI, MARIA LUIZA SILVEIRA
MELLO, ALBERTO DA SILVA MORAES
O -8
ROLE OF SIRT1 IN THE ESTABLISHMENT OF ABERRANT EPIGENETIC
MARKS ASSOCIATED WITH MELANOCYTE MALIGNANT TRANSFORMATION
FABIANA MARCELINO MELISO, FERNANDA MOLOGNONI, MIRIAM GALVONAS
JASIULIONIS
O -9
EXPRESSION, EPIGENETIC REGULATION AND FUNCTION OF
GAMMA-SYNUCLEIN IN MELANOMA PROGRESSION ANA CAROLINA MONTEIRO,
CAMILA FERREIRA DE SOUZA, MIRIAM GALVONAS JASIULIONIS
O -10
GENE EXPRESSION ASSESSMENT OF THE POLYCOMB & TRITHORAX
COMPLEXES IN THE BRAIN OF FAT-TISSUE-IMPLANTED POLYCYSTIC OVARIAN
SYNDROME MICE EDUARDO HENRIQUE DA SILVA FREITAS, SAMUEL MARCOS
RIBEIRO DE NORONHA, CARLOS FERNANDES BAPTISTA, MARIA DE NAZARETH
GAMBOA RITTO, JORGE KEDE, ISIDORO BINDA NETO, SILVANA APARECIDA ALVES
CORREA DE NORONHA, ISMAEL DALE COTRIM GUERREIRO DA SILVA
O -11
THE PATTERN OF WNT5A GENE METHYLATION DIFFERS FROM
MEDULLARY THYROID CARCINOMA (MTC) CELL LINE AND WITHIN SIBLINGS
CARRYING THE SAME RET C634R ACTIVATING MUTATION, AND CORRELATES
WITH EARLY ONSET OF FAMILIAL MTC TUMOR MIRIAN GONÇALVES CARDOSO,
MARINA MALTA LETRO KIZYS, MICHELLE YURI HARADA, DANIELA FILIPPINI
IERARDI, SUSAN CHOW LINDSEY, FLÁVIA DE OLIVEIRA FACURI VALENTE, MARIA
CLARA DE CARVALHO MELO, ROSANA DELCELO, JOÃO ROBERTO MACIEL
MARTINS, RUI MONTEIRO DE BARROS MACIEL, MIRIAM GALVONAS JASIULIONIS,
MAGNUS RÉGIOS DIAS DA SILVA
O -12
EXPRESSION PROFILE AND SUBCELLULAR LOCALIZATION OF A
NOVEL HUMAN LYSINE METHYLTRANSFERASE SETD4 IN BREAST CANCER JERUSA
ARAÚJO QUINTÃO ARANTES FARIA, CAROLINA ANDRADE, ANA CAROLINA DE
ANGELIS CAMPOS, HELENICE GOBBI, ALFREDO MIRANDA GOES, DAWIDSON ASSIS
GOMES, FABIO PITTELLA SILVA
O -13
EPIGENETIC
MODIFIERS
5-AZA-2’-DEOXYCYTIDINE
AND
TRICHOSTATIN A INFLUENCE ADIPOCYTE DIFFERENTIATION OF HUMAN
MESENCHYMAL STEM CELLS JAIESA ZYCH, CRISCIELE KULIGOVSKI, MARCO A
STIMAMIGLIO, ALEXANDRA SENEGAGLIA, PAULO S BROFMAN, BRUNO
DALLAGIOVANNA, SAMUEL GOLDENBERG, ALEJANDRO CORREA
O -14
VASCULAR DYSFUNCTION IN IUGR UMBILICAL VEIN IS
ACCOMPANIED WITH EPIGENETIC ALTERATIONS IN ENOS PROMOTER.
BERNARDO JAVIER KRAUSE LEYTON, IVO CARRASCO WONG, PAOLA CASANELLO
TOLEDO
O -15
EPIGENETIC EVENTS SEEM TO BE IMPORTANT TO DYNAMIC
PHENOTYPE SWITCHING ALONG MELANOCYTE MALIGNANT TRANSFORMATION
ALICE SANTANA MORAIS, MIRIAM GALVONAS JASIULIONIS
O -16
PROMOTER
HYPERMETHYLATION
OF
E-CADHERIN
IN
ASTROCYTOMAS WALLAX AUGUSTO SILVA FERREIRA, MARIANA DINIZ ARAÚJO,
SYMARA RODRIGUES-ANTUNES, MARICELI BAIA DOS SANTOS, NILSON PRAIA
ANSELMO, JOSÉ REGINALDO NASCIMENTO BRITO, MARIA LÚCIA HARADA,
ROMMEL MARIO RODRIGUEZ BURBANO, BÁRBARA DO NASCIMENTO BORGES
O -17
METHYLATION PATTERN OF MIR-124A2 AND MIR-124A3 IN
ASTROCYTIC TUMORS MARICELE BAIA DOS SANTOS, MARIANA DINIZ ARAÚJO,
WALLAX AUGUSTO SILVA FERREIRA, SYMARA RODRIGUES-ANTUNES, JOSÉ
REGINALDO NASCIMENTO BRITO, DOUGLAS VASCONCELOS, NILSON PRAIA
ANSELMO, ROMMEL MARIO RODRIGUEZ BURBANO, MARIA LÚCIA HARADA,
BÁRBARA DO NASCIMENTO BORGES
O -18
REGULATION OF SUGARCANE MICRORNAS IN PATHOGENS
RESPONSES BÁRBARA COSTA PEIXOTO, FLÁVIA THIBEAUT, CRISTIAN ANTONIO
ROJAS, ADRIANA SILVA HEMERLY, PAULO CAVALCANTI GOMES FERREIRA
P – Extracellular Matrix
P1-P37
P-1
HISTOLOGICAL AND ULTRASTRUCTURAL ANALYSIS OF THE EFFECTS
OF ELECTRICAL STIMULATION ON CARTILAGE HEALING IN ADULT MALE RATS
(RATTUS NORVEGICUS). DENISE CRISTINA ZUZZI, CARLA DE CAMPOS CICCONE,
PAULO PINTO JOAZEIRO, LAURECIR GOMES, MARCELO AUGUSTO MARRETTO
ESQUISATTO
P-2
STRUCTURAL FEATURES OF THE HYALINE CARTILAGE DURING
REPAIR PROCESS IN IMMATURE MALE RATS (RATTUS NORVEGICUS) TREATED
WITH MICROCURRENT. CARLA DE CAMPOS CICCONE, DENISE CRISTINA ZUZZI,
PAULO PINTO JOAZEIRO; LAURECIR GOMES; MARCELO AUGUSTO MARRETTO
ESQUISATTO
P-3
PSYCHOLOGICAL STRESS AND FISH OIL SUPLEMENTATION ON
CUTANEOUS WOUND HEALING ALICE DOS SANTOS ROSA, LUANA GABRIELA
BANDEIRA, ANDRÉA MONTE-ALTO-COSTA, BRUNA ROMANA-SOUZA
P-4
OVARIAN HORMONES EFFECT ON BIGLYCAN SECRETION BY
DECIDUAL CELLS IN VITRO AMBART ESTER COVARRUBIAS CISTERNA, MARIANA
CASTRO ÁVILA, VANESSA MORAIS FREITA, TELMA MARIA TENORIO ZORN
P-5
HETEROLOGOUS EXPRESSION, PURIFICATION AND ACTIVITY OF A
HYALURONIDASE FROM BROWN SPIDER VENOM LOXOSCELES INTERMEDIA
VALÉRIA PEREIRA FERRER, THIAGO LOPES DE MARI, LUIZA HELENA GREMSKI,
RAFAEL BERTONI DA SILVEIRA, OLGA MEIRI CHAIM, ANDREA SENFF RIBEIRO,
SILVIO SANCHES VEIGA
P-6
STRUCTURAL AND BIOCHEMICAL MODIFICATIONS IN TENDON
FIBROCARTILAGE METAPLASIA OF BULLFROGS (RANA CATESBEIANA) DURING
MATURATION AND AGING. VALDENILSON JOSÉ ZORÉL, LAURECIR GOMES,
MARCELO AUGUSTO MARRETTO ESQUISATTO
P-7
POSTMETAMORPHOSIS MATURATION OF ARTICULAR CARTILAGE
FROM THREE ANATOMICAL SITES IN BULLFROG (RANA CATESBEIANA) KNEE
JOINT: A STRUCTURAL STUDY. ANDRÉ HEBLING, MARCELO AUGUSTO MARRETTO
ESQUISATTO, LAURECIR GOMES
P-8
STRUCTURAL ANALYSIS OF THE REPAIR PROCESS IN SKIN WOUNDS
EXPERIMENTALLY INDUCED IN MALE WISTAR RATS (RATTUS NORVEGICUS).
THAIS LARISSA PEROTTI, MARINA VIGANÓ PENTEADO, JOSÉ EDUARDO SCABORA,
MARCELO AUGUSTO MARRETTO ESQUISATTO
P-9
EFFECT OF PROTEIN RESTRICTION DIET ON THE REPAIR PROCESS IN
SKIN WOUNDS, EXPERIMENTALLY INDUCED, IN FEMALE WISTAR RATS (RATTUS
NORVEGICUS). MARINA VIGANÓ PENTEADO, THAIS LARISSA PEROTTI, JOSE
EDUARDO SCABORA, MARCELO AUGUSTO MARRETTO ESQUISATTO
P - 10
EFFECTS OF MICROCURRENT AND INGAP-LASER (670NM) IN THE
REPAIR OF EXPERIMENTAL WOUNDS IN HEALTHY AND ALLOXAN-DIABETIC RATS.
LIA MARA GROSSO NEVES, RAFAEL LUÍS MATHEUS, MARCELO AUGUSTO
MARRETO ESQUISATTO, MARIA ESMÉRIA COREZOLA DO AMARAL, GLAUCIA
MARIA TECH DOS SANTOS, FERNANDA APARECIDA SAMPAIO MENDONÇA
P - 11
DIFFERENTIAL DISTRIBUTION AND REMODELING OF ELASTIC
SYSTEM FIBERS IN THE HEART OF SPONTANEOUSLY HYPERTENSIVE RATS MILENE
SANCHES GALHARDO, MARIANA METERA VERAS, JULIANA MORA VERIDIANO,
MARCELO ALVES FERREIRA, OLGA MARIA DE TOLEDO CORRÊA, MARIA CLAUDIA
IRIGOYEN, ELIA GARCIA CALDINI
P - 12
BETA-ADRENOCEPTOR
BLOCKADE
COMPROMISES
THE
CUTANEOUS WOUND HEALING OF CHRONIC LESIONS THATIANA L. ASSIS DE
BRITO, ANDRÉA MONTE-ALTO-COSTA, BRUNA ROMANA-SOUZA
P - 13
ULTRASTRUCTURAL
AND
BIOCHEMICAL
ANALYSIS
OF
EXTRACELLULAR MATRIX IN SCIATIC NERVE FROM WISTAR MALE RATS DURING
MATURATION AND AGING HALINE BALLESTERO FÊO, ANDREA APARECIDA DE
ARO, LAURECIR GOMES, MARCELO AUGUSTO MARRETTO ESQUISATTO
P - 14
BIOCHEMISTRY AND HISTOCHEMISTRY OF OLIGOCHAETAS:
LOCALIZATION AND CHARACTERIZATION OF SULFATED GLYCOSAMINOGLYCANS
IN THE BODY OF THE EARTHWORM EISENIA ANDREI LAINA CRISTINA FERREIRA,
RITA DE CASSIA LIMA MARTINS, CELIA YELIMAR PALMERO QUINTANA, LUIZ
EURICO NASCIUTTI, LUIZ CLAUDIO FRANCISCO DA SILVA
P - 15
EFFECT OF THE ALOE VERA OINTMENT IN THE REORGANIZATION
OF THE COLLAGEN FIBERS DURING TENDON HEALING ANDREA APARECIDA DE
ARO, BENEDICTO DE CAMPOS VIDAL, UMAR NISHAN, MYLENA OLIVEIRA PEREZ,
RODNEY A. RODRIGUES, MARY ANN FOGLIO, JOAO ERNESTO DE CARVALHO,
LAURECIR GOMES, EDSON ROSA PIMENTEL
P - 16
EFFECT OF THE CALENDULA OFFICINALIS CREAM DURING THE
INFLAMMATORY PHASE OF TENDON HEALING MYLENA OLIVEIRA PEREZ, ANDREA
APARECIDA DE ARO, CRISTIANO PEDROZO VIEIRA, RODNEY A. RODRIGUES,
LAURECIR GOMES, EDSON ROSA PIMENTEL
P - 17
BIOMECHANICAL PROPERTIES OF INTERPUBIC TISSUES DURING
PREGNANCY AND AFTER DELIVERY OF MICE C57BL6 M. M. M. SILVA, V. S. ROSA,
S. R. CONSONNI, L. C. V. ALVES, P. P. JOAZEIRO
P - 18
THE FOLLICULAR THYROID CELL LINE PCCL3 DIFFERENTIALLY
RESPONDS TO LAMININ AND TO POLYLAMININ, A POLYMERIC FORM OF
LAMININ ASSEMBLED AT ACIDIC PH CELIA YELIMAR PALMERO QUINTANA,
LEANDRO MIRANDA ALVES, MADALENA M. SANT’ANA BARROSO, ELAINE C. DE
SOUZA, DANIEL E. MACHADO, ANTONIO PALUMBO JUNIOR, CARLOS A. DO
NASCIMENTO, CLAUDIA S. MERLMESTEIN, CHRISTINA M. TAKIYA, DENISE P.
CARVALHO, CAMILA HOCHMAN MENDEZ, TATIANA COELHO-SAMPAIO, LUIZ
EURICO NASCIUTTI
P - 19
COLLAGEN GLYCATION TO GENERATE SKIN RECONSTRUCTED
MIMICKING AGED AND DIABETIC SKIN IN VITRO PAULA COMUNE PENNACCHI,
MAÍRA ESTANISLAU SOARES DE ALMEIDA, MARIA CLARA DE ARAÚJO CREPALDI,
MARINILCE FAGUNDES DOS SANTOS, SILVYA STUCHI MARIA-ENGLER
P - 20
EXTRACELLULAR MATRIX ALTERATIONS IN INTERVERTEBRAL DISC
DEGENERATION MARIA BETHANIA ROSSI PIVA, LILIAN ZERBINATTI OLIVEIRA,
CINTIA PEREIRA OLIVEIRA, CAMILA DE MELO ACCARDO, IVARNE LUIS DOS SANTOS
TERSARIOL, HELENA BONCIANI NADER, LUCIANO MILLER REIS RODRIGUES, MARIA
APARECIDA DA SILVA PINHAL
113
P - 21
IN VITRO EFFECTS OF SILVER NANOPARTICLES ON HUMAN
FIBROBLAST LARISSA FERNANDA DE ARAUJO VIEIRA, IANA MAYANE MENDES
NICÁCIO VIANA, CÁSSIO ERÁCLITO ALVES DOS SANTOS, ANA RÚBIA BATISTA
RIBEIRO, JANDIR MIGUEL HICKMANN, SALETE SMANIOTTO
Q – Gene Therapy
P - 22
EVALUATION
OF
FIBRILLIN-1'S
ROLE
IN
ARTERIAL
THROMBOGENESIS. PLATELETS PROTEOMIC ANALYSIS. CATHERINE NATALIA
PEREIRA, DANIEL MARTINS-DE-SOUZA, ADRIANA PAES LEME, LYGIA V. PEREIRA,
CRISTINA P. VICENTE, JOSÉ CAMILLO NOVELLO, CLAUDIO C. WERNECK
Q1-Q5
P - 23
NOVEL ALPL GENETIC ALTERATION AFFECTING THE TNAP
COLLAGEN
BINDING
DOMAIN
IS
ASSOCIATED
WITH
AN
ODONTOHYPOPHOSPHATASIA PHENOTYPE LUCIANE MARTINS, THAISÂNGELA L.
RODRIGUES, MARIANA MARTINS RIBEIRO, MIKI TAKETOMI SAITO, ANA PAULA
OLIVEIRA GIORGETTI, ENILSON ANTONIO SALLUM, MÁRCIO ZAFFALON CASATI,
FRANCISCO HUMBERTO NOCITI JUNIOR
P - 24
IN VITRO EFFECTS OF INSULIN-LIKE GROWTH FACTOR-1 AND
CHEMOKINE LIGAND-2 ON ENDOTHELIAL CELLS IANA MAYANE MENDES NICÁCIO
VIANA, MAÍRA ESTANISLAU SOARES DE ALMEIDA, MARIA DANIELMA DOS SANTOS
REIS, MARVIN PAULO LINS, SILVANA AYRES-MARTINS, SALETE SMANIOTTO
P - 25
METALOPROTEINASES, MYOFIBROBLASTS AND KI-67 EVALUATION
IN KERATOCYSTIC ODONTOGENIC TUMOR AND FOLLICLE PERICORONAL GRASIELI
DE OLIVEIRA RAMOS, ALINE COSTA, JULIANA CRISTINA PORTO, DANIELLA SERAFIN
COUTO VIEIRA, ELENA RIET CORREA RIVERO
P - 26
INHIBITION OF TGF-Β PATHWAY REVERTS EXTRACELLULAR
MATRIX REMODELING IN T. CRUZI-INFECTED CARDIAC MICROTISSUES PATRÍCIA
MELLO FERRÃO, MARIANA CALDAS WAGHABI, LUCIANA RIBEIRO GARZONI
P - 27
DISTRIBUTION OF PROTEOGLYCANS IN ANEURYSM AND
DISSECTION OF THE HUMAN ASCENDING AORTA THIAGO HENRIQUE SCHULTZ,
VINÍCIUS ORNELAS BICALHO, RICARDO RIBEIRO DIAS, NOEDIR ANTONIO GROPPO
STOLF, PAULO SAMPAIO GUTIERREZ, LUCIANO DE FIGUEIREDO BORGES
P - 28
MESTEROLONE AND AEROBIC EXERCISE EFFECTS ON THE ECM OF
THE TAIL TENDON OF C57BL/6 TRANSGENIC MICE. TATIANA CARLA TOMIOSSO,
KARINA FONTANA, MARIA ALICE DA CRUZ HÖFLING G, EDSON ROSA PIMENTEL
P - 29
EXPRESSION AND DISTRIBUTION OF ANNEXIN II IN ANEURYSM
AND DISSECTION OF THE HUMAN ASCENDING AORTA SÁVIO MELO RABELO,
MILLANE VIEIRA SANTOS, RICARDO RIBEIRO DIAS, NOEDIR ANTONIO GROPPO
STOLF, PAULO SAMPAIO GUTIERREZ, LUCIANO DE FIGUEIREDO BORGES
P - 30
DERMAL EQUIVALENT WITH MELANOMA AS A PLATFORM TO
SCREENING ANTITUMORAL MOLECULES MANOELA TIAGO DOS SANTOS, CARLA
ABDO BROHEM, EDSON MENDES OLIVEIRA, RAFAEL DUARTE PAES, ANA CAMPA,
SILVIA BERLANGA DE MORAES BARROS, SILVYA STUCHI MARIA ENGLER
P - 31
ROLE OF LAMININ ISOFORMS IN THE PROLIFERATION,
MIGRATION, DIFFERENTIATION AND DEATH OF HUMAN MYOBLASTS:
APPLICATION FOR CELL THERAPY INGO RIEDERER, ELISA NEGRONI, DANIELLE
INGRID BEZERRA DE VASCONCELOS, ELIANE CORREA DE SANTANA, DAIANE
CRISTINA FERREIRA GOLBERT, MARCELO RIBEIRO ALVES, CAMILA SANCHES,
SORAYA CHAOUCH, GILLIAN SANDRA BUTLER BROWNE, VINCENT MOULY, WILSON
SAVINO
P - 32
INFLUENCE OF OPN ON MINERALIZATION OF OSTEOGENIC CELLS
CULTURED ON A NANOSTRUCTURED TITANIUM SURFACE ADRIEL HENRIQUE
PEIXOTO DA SILVA GERALDO, FABÍOLA SINGARETTI DE OLIVEIRA, RICARDO DELLA
COLETTA, ADALBERTO LUIZ ROSA, PAULO TAMBASCO DE OLIVEIRA, PATRICIA
ADACHI
P - 33
TRITERPENE
UVAOL
STIMULATES
PHAGOCYTOSIS
AND
EXTRACELLULAR MATRIX PRODUCTION IN PERITONEAL MACROPHAGES IN
VITRO. REBEKA RAÍSA SOUZA DE MELO, IANA MAYANE MENDES NICÁCIO VIANA,
LARISSA FERNANDA DE ARAÚJO VIEIRA, ALTAIR ROGÉRIO ALVES BRANDÃO,
EMILIANO BARRETO, SALETE SMANIOTTO
P - 34
TISSUE ENGINEERED THREE DIMENSIONAL IN VITRO:
DECELLULARIZATION AND RECELULARIZATION OF THE KIDNEYS. ANDREZA
BASTOS MARTINS, BERNARDO JORGE DA SILVA MENDES, ANTONIO CARLOS
CAMPOS DE CARVALHO, JORGE LUIZ DA CUNHA MORAES, JOSE ROBERTO SILVA,
RODRIGO NUNES DA FONSECA, CINTIA MONTEIRO DE BARROS, JACKSON DE
SOUZA MENEZES, REGINA COELI DOS SANTOS GOLDENBERG
P - 35
HEPARANASE-1 SILENCING COMPROMISES SMOOTH MUSCLE CELL
DIFFERENTIATION DURING VENTRAL PROSTATE MORPHOGENESIS IN VITRO
GUILHERME OLIVEIRA BARBOSA, TAIZE AUGUSTO MACHADO, ALEXANDRE BRUNI
CARDOSO, HERNANDES F. CARVALHO
P - 36
EFFECT OF THE TREATMENT WITH STATINS ON THE DEEP DIGITAL
FLEXOR TENDON OF RATS LETÍCIA PRADO DE OLIVEIRA, CRISTIANO PEDROZO
VIEIRA, FLÁVIA DA RÉ GUERRA, EDSON ROSA PIMENTEL
P - 37
CHRONIC ADMINISTRATION OF STATINS CAUSES BIOCHEMICAL
CHANGES IN ACHILLES TENDON LETÍCIA PRADO DE OLIVEIRA, CRISTIANO
PEDROZO VIEIRA, FLÁVIA DA RÉ GUERRA, EDSON ROSA PIMENTEL
Q -1
GM-CSF GENE THERAPY TO RABBIT HIND LIMB ISCHEMIA
LEONARDO MARTINS SILVA, VIVIAN YOSHIKO SAMOTO, PRISCILA MARTINS
ANDRADE DENAPOLI, LEONARDO PINTO CARVALHO, ALEXANDRE SOUTO, JOÃO
CARLOS COSTA BAPTISTA SILVA, SANG WON HAN
Q -2
MESENCHYMAL STEM CELLS LOWER PROLIFERATION AND
INVASION OF GLIOBLASTOMA CELLS, EXPLOITING THE IMMUNE RESPONSE
MEDIATING CHEMOKINES TAMARA T. LAH, MOTALN H, GRUDEN K, HREN M,
PRIMON M, SCHICHOR CH
Q -3
INHIBITORY EFFECT OF ENDOSTATIN ON TUMOR CELL DENSITY IN
METASTATIC RENAL CELL CARCINOMA ZENÓBIO ANTONIO VIANA DE BARROS,
MARINA DE SOUZA BRAGA, KAREN CRISTINA BARBOSA CHAVES, MARIA HELENA
BELLINI
Q -4
INTRAPERITONEAL INJECTION EFFECT OF MESENCHYMAL STEM
CELLS MODIFIED WITH IDUA TO TREAT MUCOPOLYSACCHARIDOSIS TYPE I IN
MPSI MOUSE PRISCILA KEIKO MATSUMOTO MARTIN, ROBERTA SESSA STILHANO,
FLAVIA HELENA DA SILVA, VIVIAN YOSHIKO SAMOTO, GIOVANI BRAVIN PERES,
SANG WON HAN
Q -5
EXPRESSION OF A PROAPOPTOTIC MYOSIN VA FRAGMENT
RETARDS MELANOMA TUMOR GROWTH IN ANIMAL MODEL ANTONIO CARLOS
BORGES, PABLO MARCO PEIXOTO, ANA PAULA BARRETO DE PAIVA, DENISE
PIMENTA DA SILVA LEITAO-MAZZI, KATHLEEN W KINNALLY, ENILZA MARIA
ESPREAFICO
R – Host-Parasite
Interaction
R1-R75
R -1
EVALUATION OF JOANNESIA PRINCEPS AQUEOUS EXTRACT
ANTHELMINTIC ACTIVITY IN NATURALLY INFECTED MICE BY SYPHACIA
OBVELATA, ASPICULURIS TETRAPTERA AND VAMPIROLEPIS NANA. HELCIO
RESENDE BORBA, JENNIFER VIEIRA GOMES, JESSICA TAMARA DOS SANTOS
TEIXIERA, MARIANA DA SILVA DE MELLO, PATRÍCIA FAMPA, LENÍCIO GONÇALVES,
FRANCISCO DE ASSIS DA SILVA, VIVIANE MOREIRA DE LIMA
R -2
THE DIVERSE AND DYNAMIC NATURE OF LEISHMANIA
PARASITOPHOROUS VACUOLES STUDIED BY MULTIDIMENSIONAL IMAGING
FERNANDO ROBERTO OLIVEIRA REAL, RENATO ARRUDA MORTARA
R -3
MORPHOLOGICAL CHANGES IN THE CYST WALL OF THE PARASITE
GIARDIA LAMBLIA DURING EXCYSTATION PROCESS VICTOR DO VALLE PEREIRA
MIDLEJ, ISADORA PEIXOTO MEINIG, MARLENE BENCHIMOL
R -4
TRITRICHOMONAS FOETUS EXPRESSES DIFFERENT ECTOPHOSPHATASE ACTIVITIES DURING THE PSEUDOCYST FORMATION ANTONIO
PEREIRA-NEVES, JOSÉ ROBERTO MEYER-FERNADES, MARLENE BENCHIMOL
R -5
PRIMARY CULTURES OF SEVERAL TISSUES FROM THE MOLLUSK
BIOMPHALARIA TENAGOPHILA (ORBIGNY, 1835), VECTOR OF SCHISTOSOMIASIS
ARISTEU SILVA NETO, AMANDA CIPRIANO ARAÚJO, MARIANA PEDROSA GARCIA,
CONSUELO LATORRE FORTES DIAS, PAULO MARCOS ZECH COELHO, LUCIANA
MARIA SILVA
R -6
STRUCTURAL AND ULTRASTRUCTURAL CHARACTERIZATION OF
PRIMARY CULTURE CELLS FROM DIFFERENT TISSUES OF BIOMPHALARIA
TENAGOPHILA ARISTEU SILVA NETO, LUIZ CARLOS ALVES, FÁBIO ANDRÉ BRAYNER
DOS SANTOS, CONSUELO LATORRE FORTES DIAS, PAULO MARCOS ZECH COELHO,
LUCIANA MARIA SILVA
R -7
INVESTIGATION ON THE BEHAVIOR OF TRICHOMONAS TENAX
ÉRIKA BERTOZZI, IVONE DE ANDRADE ROSA, LUIZ CARLOS DOS SANTOS RIBEIRO,
MARLENE BENCHIMOL
R -8
IDENTIFICATION OF FLAGELLATED PROTISTS IN THE GUT OF THE
TERMITE COPTOTERMES GESTROI LIGIA FERREIRA NASCIMENTO, SEVERINO A.
LUCENA, REGINALDO CONSTANTINO, MARLENE BENCHIMOL
R -9
LYSOSOME DYNAMICS: WHAT IS THE IMPORTANCE OF
CHOLESTEROL FOR T. CRUZI ENTRY INTO CELLS? BÁRBARA HISSA DE CARVALHO
VIEIRA COUTO, PAULA MAGDA DA SILVA ROMA, ANA PAULA ALVES, FÁBIO
PEREIRA SANTOS, ANA MARIA DE PAULA, UBIRAJARA AGERO BATISTA, OSCAR
NASSIF DE MESQUITA, CRISTINA GUATIMOSIM FONSECA, LUCIANA DE OLIVEIRA
ANDRADE
114
R -10
COMPARATIVE STUDY OF SYNTHESIZED PENTAVALENT
ANTIMONIAL COMPOUNDS WITH GLUCANTIME IN MURINE MODEL KELLY
CRISTINA KATO, ADRIEL ARAÚJO FERNANDES FERREIRA, ELIANE DE MORAIS
TEIXEIRA, ANA LÚCIA TELES RABELLO, CYNTHIA PERES DEMICHELI, MARCELA
SANTOS PROCÓPIO, FREDERIC JEAN GEORGES FREZARD, JOSÉ DIAS CORRÊA
JUNIOR
R -11
SALIVARY GLAND AS A SOURCE OF NEUROTROPHIC FACTOR IN
EXPERIMENTAL TRYPANOSOMIASIS LUCIANA DE OLIVEIRA ANDRADE, RICARDO
TOSHIO FUGIWARA, LUISA ALMEIDA FIGUEIREDO, EGLER CHIARI, PATRICIA
MASSARA MARTINELLI, PATRICIA MASSARA MARTINELLI
R -12
CYTOKINE POLYMORPHISMS ANALYSIS IN PATIENT WITH
AMERICAN CUTANEOUS LEISHMANIASIS FÁBIO RIBEIRO QUEIROZ, FLÁVIA
PERRIM DE MELO, LETICIA DA CONCEIÇÃO BRAGA, ANA CRISTINA DE CARVALHO
BOTELHO, LINTON WALLIS FIGUEIREDO SOUZA, LUCIANA MARIA SILVA
R -13
IMMUNE RESPONSE IN RAT NEURON-GLIA CO-CULTURES
INFECTED WITH NEOSPORA CANINUM: ROLE OF OXIDE NITRIC SYNTHETASE
INDUCIBLE ALEX BARBOSA DOS SANTOS, ERICA ETELVINA VIANA DE JESUS,
GREGORY FERRAZ, ALEXANDRE MORAES PINHEIRO, CÁTIA SUSE RIBEIRO, MAIARA
REIS ARRUDA, ISABELA COSTA BARRETO DE ALMEIDA, SILVIA COSTA, MARIA DE
FÁTIMA DIAS COSTA
R -14
DECREASE OF CCL2 IN MOUSE INFECTED WITH LEISHMANIA
BRAZILIENSIS IN THE PRESENCE OF ADENOSINE SAMARA FREIRE VALENTE, THAIS
VIANA FIALHO, LEANDRO LICURSI DE OLIVEIRA, SÉRGIO OLIVEIRA DE PAULA, LUÍS
CARLOS CROCCO AFONSO, EDUARDO DE ALMEIDA MARQUES DA SILVA
R -15
REORGANIZATION OF THE MYOCARDIAL MORPHOLOGY AND
CARDIOMYOCYTES
MECHANICAL
PROPERTIES
IN
EXPERIMENTAL
TRYPANOSOMA CRUZI INFECTION RÔMULO DIAS NOVAES, ARLETE RITA
PENITENTE, MARTA ROCHA ARAÚJO, REGGIANI VILELA GONÇALVES, ANDRÉ
TALVANI, CLÓVIS ANDRADE NEVES, ANTÔNIO JOSÉ NATALI, IZABEL REGINA DOS
SANTOS COSTA MALDONADO
R -16
EFFECT OF PREINFECTION TREADMILL TRAINING ON THE
MORPHOLOGY AND FUNCTION OF CARDIOMYOCYTES IN A MURINE MODEL OF
CHAGAS’ CARDIOMYOPATHY RÔMULO DIAS NOVAES, ARLETE RITA PENITENTE,
MARTA ROCHA ARAÚJO, REGGIANI VILELA GONÇALVES, ANDRÉ TALVANI, CLÓVIS
ANDRADE NEVES, ANTÔNIO JOSÉ NATALI, IZABEL REGINA DOS SANTOS COSTA
MALDONADO
R -17
APOE4/4 TARGETED REPLACEMENT AND APOE KNOCKOUT
WEANLING
MICE
HAVE
DISTINCT
ADAPTATIONS
FOLLOWING
CRYPTOSPORIDIUM PARVUM INFECTION AND MALNUTRITION ORLEÂNCIO
GOMES RIPARDO DE AZEVEDO, DAVID BOLICK, ALDO A. M. LIMA, MICHEL P. VITEK,
REINALDO B. ORIA, JAMES K. ROCHE, RICHARD L. GUERRANT
R -18
ISOLATION
AND
PURIFICATION
OF
LEISHMANIA
INFANTUM/CHAGASI LECTINS. THAÍS VIANA FIALHO MARTINS, SAMARA FREIRE
VALENTE, SÍLVIA ALMEIDA CARDOSO, SÉRGIO OLIVEIRA DE PAULA, LEANDRO
LICURSI DE OLIVEIRA, EDUARDO DE ALMEIDA MARQUES DA SILVA
R -19
HEMOLYMPH CELLS OF LYMNAEA COLUMELLA, SAY, 1817, A
VECTOR FOR FASCIOLOSIS IN BRAZIL VINICIUS MARQUES ANTUNES RIBEIRO,
ARISTEU SILVA NETO, LUCIANA MARIA SILVA, WALTER DOS SANTOS LIMA
R -20
COMPARISON OF THE ADHESION TAX OF WILD AND MUTANTS
STRAINS HAEMOPHILUS INFLUENZAE IN HEC1B AND A549 CELL LINES JULIA
NOGUEIRA VARELA, MÁRIO SÉRVULO IZIDORO, JR., DANILO ANTONINI ALVES,
GISELE CRISTIANE GENTILLE CURY, LUCIANA MARIA DE HOLLANDA, RAFAELLA
FABIANA CARNEIRO PEREIRA, MARCELO LANCELLOTTI
R -21
WHY COINFECT CELLS WITH NON-VIRAL PATHOGENS? MICHEL
RABINOVITCH
R -22
IMMUNOHISTOCHEMICAL DETECTION OF GP43 IN THE LIVER OF
SWISS MICE WITH PARACOCCIDIOIDOMYCOSIS ELAINE SCIUNITI BENITES
MANSANO, TEREZINHA INEZ ESTIVALET SVIDZINSKI, EDILAINE MARTINS
MORATTO, MARIANA CRISTINA VICENTE UMADA ZAPATER, MARIA DOS ANJOS
FORTUNATO, LUZMARINA HERNANDES
R -23
HISTOPATHOLOGICAL EVALUATION AND PHYSICOCHEMICAL BY
RAMAN
SPECTROSCOPY
IN
LIVER
OF
SWISS
MICE
WITH
PARACOCCIDIOIDOMYCOSIS ELAINE SCIUNITI BENITES MANSANO, TEREZINHA
INEZ ESTIVALET SVIDZINSKI, EDILAINE MARTINS MORATTO, MAURO LUCIANO
BAESSO, GUTIERREZ RODRIGUÊS DE MORAIS, LUZMARINA HERNANDES
R -24
THE TREATMENT TACHYZOITES OF TOXOPLASMA GONDII ON THE
HOST CELL INTERACTION INDUCED CONVERSION FOR BRADYZOITES FORMS
LOYZE PAOLA OLIVEIRA DE LIMA, THAYANE RITA BORGES DE FARIA, JULIANA DE
ARAÚJO PORTES, PEDRO SOUTO RODRIGUES, RENATO AUGUSTO DAMATTA,
WANDERLEY DE SOUZA, SERGIO HENRIQUE SEABRA
R -25
GPI PBPGA1P OF P. BRASILIENSIS IS A SURFACE ANTIGEN THAT
ACTIVATES MAST CELLS THROUGH THE TRANSCRIPTION FACTOR NF-KAPPA B
INDEPENDENT OF THE HIGH AFFINITY IGE RECEPTOR CLARISSA XAVIER RESENDE
VALIM, LUISA KARLA ARRUDA, CONSTANCE OLIVER, PAULO SERGIO RODRIGUES
COELHO, MARIA CELIA JAMUR
R -26
MAY THE ADIPOSE TISSUE BE A TRYPANOSOMA CRUZI RESERVOIR
IN PATIENTS WITH CHRONIC CHAGAS DISEASE? ADALIENE VERSIANI MATOS
FERREIRA, MARCELA SEGATTO DO CARMO, ZÉLIA MENEZES, ÍTALO FARIA DO
VALLE, ANDRÉA MARA MACEDO, CLÁUDIO GELAPE, LUCIANA DE OLIVEIRA
ANDRADE, FNU NAGAJYOTHI, PHILIPP E. SCHERER, MAURO MARTINS TEIXEIRA,
HERBERT B. TANOWITZ
R -27
NEUTROPHIL EXTRACELLULAR TRAPS (NETS) DECREASE THE
VIABILITY OF TOXOPLASMA GONDII GABRIELA VERAS DE MORAES, TATIANA
PAREDES SANTOS, ANDERSON GUIMARÃES COSTA, ELVIRA SARAIVA, MARCIA
ATTIAS
R -28
BINDING OF THE WHEAT GERM LECTIN TO CRYPTOCOCCUS
NEOFORMANS CHITOOLIGOMERS IMPAIRS EXTRACELLULAR POLYSACCHARIDE
RELEASE, TLR2-MEDIATED INTERACTION WITH PHAGOCYTES, AND BRAIN
COLONIZATION IN MICE. FERNANDA L. FONSECA, ALLAN J. GUIMARÃES,
FABIANNO F. DUTRA, FERNANDA D. SILVA, JULIAN E. MUÑOZ, CARLOS P.
TABORDA, MARCELO T. BOZZA, LEONARDO NIMRICHTER, ARTURO CASADEVALL,
MARCIO L. RODRIGUES
R -29
ULTRASTRUCTURAL ANALYSIS OF HOST CELL CYTOSKELETON
DURING TOXOPLASMA GONDII INVASION THAYANA ARAUJO DA CRUZ, TATIANA
C. PAREDES SANTOS, WANDERLEY DE SOUZA, MARCIA ATTIAS
R -30
CRYPTOCOCCUS NEOFORMANS-MACROPHAGE INTERACTION:
CYTOSKELETON INVOLVEMENT UPON HOST CELL ENTRY CAROLINE REZENDE
GUERRA, SERGIO HENRIQUE SEABRA, SONIA ROZENTAL
R -31
IFN-GAMMA PLAYS A UNIQUE ROLE IN PROTECTION AGAINST
LOW VIRULENT TRYPANOSOMA CRUZI STRAIN ADELE AUD RODRIGUES, FABIANA
SILVA, FLÁVIA ALVES MARTINS, ANA FLÁVIA OLIVEIRA NOTÁRIO, ALINE ALVES DA
SILVA, CECÍLIO PURCINO DA SILVA SOUZA NETO, JASSON SEBASTIAN SANABRIA
SAOSA, GRACE KELLY DA SILVA, CATARINA V. HORTA, DARIO S. ZAMBONI, JOÃO
SANTANA DA SILVA, ELOISA A. V. FERRO, CLAUDIO VIEIRA DA SILVA
R -32
THE ROLE OF CYTOSKELETON, COMPONENTS OF IP3/DAG
SIGNALING PATHWAY AND IRON IN EHRLICHIA CANIS PROLIFERATION KARINE
CANUTO LOUREIRO DE ARAUJO, MARCELO ARANTES LEVENHAGEN, ROSIANE
NASCIMENTO ALVES, SUSANA ELISA RIECK, MARCELO BAHIA LABRUNA, MARCELO
EMÍLIO BELETTI
R -33
PURIFICATION PROTOCOLS OF A 21 KDA RECOMBINANT PROTEIN
BASED ON THE NATIVE TRYPANOSOMA CRUZI P21: A TOOL TO STUDY ITS
BIOLOGICAL FUNCTIONS DURING PARASITE-HOST INTERACTION MARLUS ALVES
DOS SANTOS, CLAUDIO VIEIRA DA SILVA, PAULA CRISTINA BRIGIDO, KARINE
CANUTO LOUREIRO DE ARAÚJO, PRISCILA CASTRO CORDEIRO FERNANDES
R -34
ATYPICAL ENTEROPATHOGENIC ESCHERICHIA COLI (AEPEC)
SECRETES A SOLUBLE ANTI-PHAGOCYTIC FACTOR KEYDE CRISTINA MARTINS DE
MELO, RAFAEL MARQUES PORTO, DANIEL CARVALHO PIMENTA, RITA DE CASSIA
RUIZ
R -35
3D VIEW OF INTERCONNECTIONS BETWEEN ENDOPLASMIC
RETICULUM PROFILES AND INNER MEMBRANE COMPLEX OF TOXOPLASMA
GONDII TATIANA CHRISTINA PAREDES SANTOS, WANDERLEY DE SOUZA, MARCIA
ATTIAS
R -36
TRYPANOSOMA CRUZI EXTRACELLULAR AMASTIGOTES (EAS) AND
HOST CELL SIGNALING: MORE PIECES TO THE PUZZLE DIANA BAHIA, ALEXIS
BONFIM-MELO, ÉDEN RAMALHO FERREIRA, RENATO ARRUDA MORTARA
R -37
ROLE OF REACTIVE OXYGEN SPECIES (ROS) ON NEUTROPHIL
EXTRACELLULAR TRAPS (NETS) INDUCED BY LEISHMANIA AMAZONENESIS
NATALIA CADAXO ROCHAEL, MICHELLE TANNY CUNHA DO NASCIMENTO,
ANDERSON BAPTISTA GUIMARÃES-COSTA, MATHEUS PINTO DE OLIVEIRA,
MARCUS FERNANDES DE OLIVEIRA, ELVIRA MARIA SARAIVA
R -38
INVESTIGATION OF YELLOW FEVER VIRUS-INDUCED ENDOPLASMIC
RETICULUM STRESS DANIEL SANCHES, CLAUDIA MONTEIRO DA ROCHA, SAMIR
PEREIRA DACOSTA CAMPOS, LUCIANE PINTO GASPAR, MARCOS DA SILVA FREIRE,
BRUNO SOUZA GONÇALVES, LUCIANA BARRETO CHIARINI, JERSON LIMA DA SILVA,
ANDRE MARCO DE OLIVEIRA GOMES, ANDRÉA CHEBLE DE OLIVEIRA
R -39
MEDICINAL PLANT EXTRACTS: AN ALTERNATIVE APPROACH TO
CONTROL INTRACELLULAR MULTIPLICATION OF LEISHMANIA AMAZONENSIS
SAMUEL COTA TEIXEIRA, THAISE LARA TEIXEIRA, MARIA APARECIDA DE SOUZA,
CLAUDIO VIEIRA DA SILVA
R -40
NADPH OXIDASE ACTIVATION IS ASSOCIATED WITH INVASION OF
HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS BY GROUP B STREPTOCOCCUS
JESSICA SILVA SANTOS DE OLIVEIRA, RAFAELA SILVA DOS SANTOS, PRESCILLA EMY
NAGAO, GABRIELA DOS SANTOS JONATHAN
R -41
PROTECTIVE MECANISMS IN THE SMALL INTESTINE INDUCED BY
PREVIOUS TREATMENT WITH THE SOLUBLE ANTIGEN OF TACHYZOITES (STAG) IN
MICE INFECTED ORALLY WITH TOXOPLASMA GONDII ALEXSANDRA ALVES
BEZERRA MARTINS, LUCIANA ALVES DE SOUSA, LETÍCIA BRUNO, TÚLIO HENRIQUE
DE FREITAS, PAULO VICTOR CZARNEWSKI BARENCO, ESTER CRISTINA BORGES
ARAÚJO, NEIDE MARIA SILVA
R -42
EFFECTS OF SALMONELLA ENTERITIDIS SEROVAR TYPHIMURIUM
INFECTION IN ADENOCARCINOMIC HUMAN ALVEOLAR BASAL EPITHELIAL CELLS
A549: PATHOGEN INDUCES APOPTOSIS JULIA NOGUEIRA VARELA, MÁRIO
SÉRVULO IZIDORO JR., DANILO ANTONINI ALVES, RAFAELLA FABIANA CARNEIRO
115
PEREIRA, LUCIANA MARIA DE HOLLANDA, MARCELO BROCCHI, MARCELO
LANCELLOTTI
ROQUE, SILVIA L. LAGE, ROSSANA MELO, HUGO C. CASTRO-FARIA-NETO, HELOISA
D'AVILA, PATRICIA TORRES BOZZA
R -43
IN VITRO INTERACTION OF AEROMONAS SPP. STRAINS WITH HEP2 AND CACO-2 CELL LINES ANDRÉA FONSECA FERREIRA, PAULA AZEVEDO DOS
SANTOS, ANGELA CORRÊA DE FREITAS ALMEIDA
R -62
MACROPHAGE MIGRATION INHIBITORY FACTOR ACTS AS A KEY
REGULATOR OF LIPID METABOLISM DURING DENGUE VIRUS INFECTION GISELLE
BARBOSA DE LIMA, LÍGIA DE ALMEIDA PAIVA, IRANAIA ASSUNÇÃO MIRANDA,
MARCELO TORRES BOZZA, ANDREA THOMPSON DA POIAN, PATRÍCIA TORRES
BOZZA
R -44
SCREENING OF NEW COMPOUNDS THAT INHIBIT THE REPLICATION
OF HIV-1 SANDRO COSTA POEYS, LÍDIA MOREIRA LIMA, LUCIANA JESUS DA COSTA
R -45
CYTOTOXIC ACTIVITY OF AEROMONAS STRAINS ISOLATED FROM
CLINICAL SAMPLES FOR A HUMAN INTESTINAL CELL LINE (HRT-18) ANA CAROLINE
WIPPICH, STELA COSTA, SUELEN WOLF, CYNTIA MARIA TELLES FADEL-PICHET,
KATIA SABRINA PALUDO
R -46
IN VITRO ANALYSIS OF NEISSERIA MENINGITIDIS’ INFECTION IN
HUMAN IMMORTALIZED CELLS RAFAELLA FABIANA CARNEIRO PEREIRA, MÁRIO
SÉRVULO IZIDORO JÚNIOR, RENAN KOSSEKI JACINTO, MARCELO LANCELLOTTI
R -47
THE ROLE OF THE LAS GENE IN THE VIRULENCE OF HAEMOPHILUS
INFLUENZAE BIOGROUP AEGYPTIUS ASSOCIATED WITH BRAZILIAN PURPURIC
FEVER GISELE CRISTIANE GENTILE CURY, RAFAELLA FABIANA CARNEIRO PEREIRA,
LUCIANA MARIA DE HOLANDA, MARCELO LANCELLOTTI
R -48
TRANSLATIONAL REGULATION OF IMMUNODEFICIENCY TYPE 1
VIRUS (HIV-1) BY POLIOVIRUS 2A PROTEASE RAQUEL AMORIM, SARA MESQUITA
COSTA, EDSON ELIAS DA SILVA, LUCIANA JESUS DA COSTA
R -49
TOXOPLASMA
GONDII
PERSISTENCE
IN
ACTIVATED
MACROPHAGES: INOS DEGRADATION MECHANISMS JULIANA DA CRUZ PADRÃO,
GABRIEL RABELLO DE ABREU CABRAL, SERGIO HENRIQUE SEABRA, MARIA DE
FÁTIMA SARRO DA SILVA, RENATO AUGUSTO DAMATTA
R -50
ABSENCE OF LENTIVIRAL ACCESSORY PROTEIN NEF INCREASES
HIV-1 PR CATALYTIC ACTIVITY REDUCING MATURE VIRAL PARTICLES
PRODUCTION AND ENZYME INCORPORATION LUIZA MONTENEGRO MENDONÇA,
SANDRO COSTA POEYS, LUCIANA JESUS DA COSTA
R -51
GALECTIN-3 PARTICIPATION IN TRYPANOSOMA CRUZI CELL
INVASION, INTRACELLULAR TRAFFIC AND MULTIPLICATION ALINE ALVES DA
SILVA, FABRÍCIO CASTRO MACHADO, REBECCA TAVARES E SILVA, CLAUDIO VIEIRA
DA SILVA
R -52
EFFECT OF THIOPHENACETAMIDE AGAINST MYCOBACTERIUM
BOVIS (BCG) INFECTION. FATIMA MARIA FIGUEROA VERGARA, ANDRÉ LUIS
PEIXOTO CANDÉA, PATRÍCIA PACHECO DA SILVA, MARCUS VINÍCIUS NORA, MARIA
DAS GRAÇAS MULLER DE OLIVEIRA HENRIQUES
R -53
EVALUATION OF TH1 CYTOKINE EXPRESSION DURING CEREBRAL
MALARIA INFECTION IN MSG-OBESE MICE. RENAN VILLANOVA HOMEM DE
CARVALHO, CHRISTIANE LIMA MACHADO, ANA GUALBERTO, SARA MALAGUTI
SOARES, GABRIELA COELI MENEZES EVANGELISTA, POLLYANA SALVADOR, GILSON
COSTA MACEDO, JACY GAMEIRO
R -54
ULTRASTRUCTURAL STUDY OF CANDIDA ALBICANS ADHESION TO
GERBIL (MERIONES UNGUICULATUS) VAGINAL AND UTERINE EPITHELIUM
THALITTA HETAMARO AYALA LIMA, CAROLINA MARTINS TREMÉA, LUIZ HENRIQUE
ATHAIDES RAMOS, SEBASTIÃO ROBERTO TABOGA, LÚCIA KIOKO HASIMOTO E
SOUZA, FERNANDA CRISTINA ALCANTARA DOS SANTOS, JOSIANE FAGANELLO
R -55
INVESTIGATION OF LIPID BODIES IN TRYPANOSOMA CRUZI AND
THEIR CORRELATION WITH CHAGAS’ DISEASE DANIEL AFONSO DE MENDONÇA
TOLEDO, HELOISA D’AVILA BIZARRO, LÍVIA TEIXEIRA, CÉLIO FREIRE DE LIMA,
PATRÍCIA TORRES BOZZA, ROSSANA C. N. MELO
R -56
ISOLATION AND CHARACTERIZATION OF GENES CODING FOR
PHYTOCYSTATINS FROM BLACK PEPPER- FUSARIUM SOLANI F. SP. PIPERIS
INTERACTION ALINE MEDEIROS LIMA, SÁVIO PINHO DOS REIS, WENDELL UPTON
DE BRITO, LILIANE SOUZA CONCEIÇÃO TAVARES, ELAINE CRISTINA PESSOA DOS
SANTOS, CLAUDIA REGINA BATISTA DE SOUZA
R -57
NAPHTHOQUINONE DERIVATIVE CHEMOTHERAPY ACTION IN THE
IN VITRO DEVELOPMENTAL OF TOXOPLASMA GONDII. LUCIANA LEMOS RANGEL
DA SILVA, JULIANA DE ARAÚJO PORTES, SÉRGIO HENRIQUE SEABRA, RENATO
AUGUSTO DAMATTA
R -58
THE ROLE OF UBIQUITIN-PROTEASOME SYSTEM IN VIRAL
PRODUCTION AND INFECTIVITY OF SIVCPZ MARCELA SABINO CUNHA, LUCIANA
JESUS DA COSTA
R -59
PI3K AND AKT SIGNAL PATHWAY ARE INVOLVED DURING
INVASION OF HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS BY GROUP B
STREPTOCOCCUS RAFAELA SILVA DOS SANTOS, JESSICA SILVA SANTOS DE
OLIVEIRA, GABRIELA DA SILVA SANTOS, PRESCILLA EMY NAGAO
R -63
USING PROTEOMIC ANALYSIS TO IDENTIFY CHEMOTHERAPEUTIC
AGENTS IN MACROPHAGES INFECTED WITH LEISHMANIA CARLOS EDUARDO
SAMPAIO GUEDES, BEATRIZ ROCHA SIMÕES DIAS, ANTONIO LUIS DE OLIVEIRA
ALMEIDA PETERSEN, KERCIA PINHEIRO CRUZ, NIARA DE JESUS ALMEIDA, JULIANA
PERRONE BEZERRA DE MENEZES, LUIZ ANTÔNIO RODRIGUES DE FREITAS,
PATRICIA SAMPAIO TAVARES VERAS
R -64
DENGUE AND YELLOW FEVER VIRUS-MEGAKARYOBLASTS
INTERACTION: ROLE IN HEMOSTATIC ALTERATIONS SAMIR PEREIRA DA COSTA
CAMPOS, MARIANA GARRIDO DE CASTRO, DANIEL SANCHES, CLAUDIA MONTEIRO
DA ROCHA, MARIANA FIGUEIREDO RODRIGUES, JERSON LIMA DA SILVA, ANDRE
MARCO DE OLIVEIRA GOMES, ANDRÉA CHEBLE DE OLIVEIRA
R -65
COMPARISON IN SILICO OF ZIP TRANSPORTERS EXTRACELLULAR
DOMAINS DISTRIBUTION OF LEISHMANIA SP AND MAMMAL HOSTS. JULIA
ZERLOTINI DE LUCAS, RENATA ANDRADE AVILA, IARA FREITAS LOPES, LUCIANO
RIVAROLI
R -66
MICROBICIDAL RESPONSE IN MACROPHAGES INFECTED WITH L.
(L.) AMAZONENSIS AFTER TREATMENT WITH AQUEOUS EXTRACT FROM ROOT
OF PHYSALIS ANGULATA BRUNO JOSÉ MARTINS DA SILVA, RAQUEL RAICK
PEREIRA DA SILVA, ANA PAULA DRUMMOND RODRIGUES, LUIS HENRIQUE SEABRA
DE FARIAS, CAROLINE MARTINS ALMEIDA, PAULA CRISTINA RODRIGUES FRADE,
GILMARA DE NAZARETH TAVARES BASTOS, EDILENE OLIVEIRA DA SILVA
R -67
STUDY OF THE ROLE OF DIPEPTIDYL-PEPTIDASE 8-LIKE AND
OTUBAIN GENES IN TRYPANOSOMA CRUZI INFECTION DEBORA TORRES ALVES
FIGUEIREDO, FLAVIA NADDER MOTTA ARENAS, GRAZIELLA SANTANA FEITOSA
FIGUEIREDO, JAIME MARTINS DE SANTANA, IZABELA MARQUES DOURADO
BASTOS
R -68
INFLAMMASOME ACTIVATION NEGATIVELY REGULATES LIPID
BODY BIOGENESIS DURING MYCOBACTERIUM BOVIS BCG INFECTION CARLA
FREITAS, DARIO ZAMBONI, VALÉRIE QUESNIAUX, BERNHARD RYFFEL, PATRICIA
BOZZA
R -69
THE ROLE OF SCAVENGER RECEPTOR MARCO IN INFECTION OF
MURINE MACROPHAGES WITH LEISHMANIA MAJOR NIARA DE JESUS ALMEIDA,
CARLOS EDUARDO SAMPAIO GUEDES, BEATRIZ ROCHA SIMÕES DIAS, PATRÍCIA
SAMPAIO TAVARES VERAS
R -70
HOST CELL SIGNALING PATHWAYS INVOLVED IN INVASION OF
ENTEROINVASIVE ESCHERICHIA COLI (EIEC) AND SHIGELLA FLEXNERI PATRÍCIA
FARIA PRADO, FLÁVIA ALVES MARTINS, LUCAS GONÇALVES FERREIRA, MARINA
BAQUERIZO MARTINEZ, MARIA APARECIDA DE SOUZA, CLAUDIO VIEIRA DA SILVA
R -71
EVALUATION OF TRANSLOCATOR PROTEIN EXPRESSION IN CBA
MACROPHAGES INFECTED WITH LEISHMANIA BEATRIZ ROCHA SIMÕES DIAS,
CARLOS EDUARDO SAMPAIO GUEDES, KERCIA PINHEIRO CRUZ, NIARA DE JESUS
ALMEIDA, PATRICIA SAMPAIO TAVARES VERAS
R -72
DETECTION AND IMMUNOLOCALIZATION OF THE ENZYME
CONSTITUTIVE NITRIC OXIDE SYNTHASIS (CNOS) IN PROMASTIGOTES FORMS OF
THE LEISHMANIA (VIANNIA) BRAZILIENSIS AND LEISHMANIA (LEISHMANIA)
AMAZONENSIS RODRIGO RIBEIRO FURTADO, ANA PAULA DRUMMOND
RODRIGUES, LUIS HENRIQUE SEABRA DE FARIAS, AMANDA ANASTÁCIA PINTO
HAGE, CAROLINE MARTINS ALMEIDA, BRUNO JOSÉ MARTINS SILVA, EDILENE
OLIVEIRA DA SILVA
R -73
ULTRASTRUCTURAL DIFFERENCES IN THE ENGULFMENT PROCESS
OF THREE LEISHMANIA SPECIES BY MACROPHAGE AND MICROGLIA JOSÉ
ANTONIO PICANÇO DINIZ JUNIOR, PATRÍCIA KARLA SANTOS RAMOS, MAYSA DE
VASCONCELOS BRITO
R -74
COULD SEROTONIN LEVELS IN THE INTESTINE MANAGE THE
CHAGASIC MEGACOLON DEVELOPMENT? FERNANDA CHAVES OLIVEIRA, ENIO
CHAVES OLIVEIRA, SALUSTIANO GABRIEL NETO, ALEJANDRO OSTEMAIER
LUQUETTI, AXEL BREHMER, ALEXANDRE BARCELOS MORAIS DA SILVEIRA,
MICHELLE APARECIDA RIBEIRO DE FREITAS
R -75
IN SILICO STRUCTURAL ANALYSIS OF EXTRACELLULAR DOMAIN OF
TRYPANOSOMA BRUCEI TRANSFERRIN RECEPTOR RENATA ANDRADE AVILA,
JULIA ZERLOTINI DE LUCAS, IARA FREITAS LOPES, LUCIANO RIVAROLI
R -60
CELLULAR STUDIES OF A HISTONE DESACETYLASES INHIBITOR ON
LEISHMANIA AMAZONENSIS BRUNNO RENATO FARIAS VERÇOZA, JULIANY COLA
FERNANDES RODRIGUES, WANDERLEY DE SOUZA, FRANZ BRACHER
R -61
MECHANISM OF INTERACTION BETWEEN PHAGOSOMES AND RAB
7-ENRICHED LIPID BODIES DURING MYCOBACTERIAL INFECTION NATALIA R
116
S – Methods in Cell
Biology
S1-S30
S-1
COMPARATIVE HISTOCHEMICAL ANALYSIS OF THE VENOM
GLANDS OF THE BEE, AFRICANIZED APIS MELLIFERA AND THE WASP, POLISTES
VERSICOLOR. ALINE FERNANDA CATAE, THAISA CRISTINA ROAT, MARIO SÉRGIO
PALMA, ROBERTA CORNÉLIO FERREIRA NOCELLI, OSMAR MALASPINA
CULTURES. LEANDRA SANTOS BAPTISTA, KARINA RIBEIRO SILVA, CAROLINA DA
SILVA GOUVEIA PEDROSA, RONALDO JOSÉ FARIA CORREIA DO AMARAL, JOÃO
VITOR BELIZÁRIO DOS SANTOS, RADOVAN BOROJEVIC, JOSÉ MAURO GRANJEIRO
S - 16
OPTICAL TWEEZERS TO EVALUATE THE LEISHMANIA
AMAZONENSIS AND TRYPANOSOMA CRUZI MOTILITY BEFORE AND AFTER
TREATMENT WITH LIPPIA SIDOIDES ESSENTIAL OIL ALINE DULCE PITT DA ROCHA
OLIVEIRA, DIEGO CÉSAR NUNES DA SILVA, ANA CAROLINA SANTOS ROSA NUNES,
ALINE CAROLINE DA SILVA, AMANDA SILVA DOS SANTOS ALIANÇA, DIVAR
FERNANDES PIRES NETO, ANDREZA RAPOSO BORGES, BEATE SAEGESSER DOS
SANTOS, REGINA CÉLIA BRESSAN QUEIROZ DE FIGUEIREDO, ADRIANA FONTES
S - 17
HISTOLOGICAL EVALUATION OF BIOMATERIAL CHITOSANGELATIN-BASED EFFECTS IN INTRAORAL BONE REPAIR IN RATS IGOR DANIEL
GARCIA REIS, MATHEUS HENRIQUE SANTOS ASSIS, LUIZ BERTOLDO DA COSTA
FILHO, FERNANDO ANTÔNIO MAUAD ABREU, PETERSON DE OLIVEIRA DUTRA,
ALFREDO MIRANDA GÓES, GERLUZA APARECIDA BORGES SILVA
S-2
NUCLEAR MORPHOMETRIC ANALYSIS (NMA): A NEW METHOD
FOR SCREENING OF APOPTOSIS, MITOSIS, SENESCENCE AND MITOTIC
CATASTROPHE EDUARDO CREMONESE FILIPPI CHIELA, MANUEL MENEZES DE
OLIVEIRA NETO, BRUNO JURKOVSKI, SÍDIA MARIA JACQUES-CALLEGARI, VINÍCIUS
DUVAL DA SILVA, GUIDO LENZ
S - 18
PREDICTION OF AUTOPHAGY IN VITRO BY A COLORIMETRIC
APPROACH WALESKA KERLLEN MARTINS GARDESANI, DIVINOMAR SEVERINO,
CLEIDIANE SOUZA, BEATRIZ SIMONSEN STOLF, MAURÍCIO SILVA BAPTISTA
S-3
SECRETION SYNTHESIS BY VENOM RESERVOIR OF WASP
TRYPOXYLON LACTITARSE SAUSSURE (HYMENOPTERA: CRABRONIDAE) JÔNATAS
CHAGAS DE OLIVEIRA, RUSLEYD MARIA MAGALHÃES DE ABREU
S - 19
FLUORESCENCE PLATE READER TO EVALUATE CDTE/CDS-MPA AND
CDTE/CDS-MSA BIOCONJUGATION TO ANTI-A ANTIBODIES – APPLICATIONS IN
IMMUNOHEMATOLOGY PAULO EUZEBIO CABRAL FILHO, KILMARA HIGIA GOMES
CARVALHO, ALUIZIO GONÇALVES BRASIL JUNIOR, ELISA SOARES LEITE, BEATE
SAEGESSER SANTOS, ADRIANA FONTES
S-4
STANDARDIZATION OF TOTAL DNA QUANTIFICATION AND
DETERMINATION OF AT/CG BASE PAIRS COMPOSITION METHODOLOGIES FOR
STINGLESS BEES, BY MEANS OF FLOW CYTOMETRY FERNANDA APARECIDA
FERRARI SOARES, CARLOS ROBERTO CARVALHO, MARA GARCIA TAVARES
S-5
DIFFERENTIAL HSP 70 AND HYPOXIA-INDUCIBLE FACTOR 1A (HIF1A) EXPRESSION IN LIVER OF PROCHILODUS ARGENTEUS CAUGHT IN DIFFERENT
SITES OF SÃO FRANCISCO RIVER HEDER JOSÉ RIBEIRO, MARCELA SANTOS
PROCÓPIO, FABIANA ALVES, DEBORAH RIBEIRO NASCIMENTO, ALMIR DE SOUSA
MARTINS, JOSÉ DIAS CORRÊA JUNIOR
S-6
CDTE/CDS QUANTUM DOTS BIOCONJUGATED TO CONCANAVALIN
A LECTIN TO STUDY CARBOHYDRATES EXPRESSION IN CANDIDA ALBICANS
DENISE PATRÍCIA LINS AZEVEDO TENÓRIO, CAMILA GALVÃO DE ANDRADE, PAULO
EUZÉBIO CABRAL FILHO, CAMILA CAMPOS SANTOS, ILKA TIEMY KATO, MARTHA
SIMÕES RIBEIRO, SEVERINO ALVES JUNIOR, EDUARDO ISIDORO CARNEIRO
BELTRÃO, LUIZ BEZERRA DE CARVALHO JUNIOR, ADRIANA FONTES, BEATE
SAEGESSER SANTOS
S-7
IDENTIFICATION OF PARAPOXVIRUS ISOLATED FROM AN
OUTBREAK IN GOATS IN CEARÁ STATE, BRAZIL, BY TRANSMISSION ELECTRON
MICROSCOPY TECHNIQUES. MARCIA HELENA BRAGA CATROXO, ANA MARIA
CRISTINA RABELO PINTO DA FONSECA MARTINS, SELMA PETRELLA, FABÍOLA DE
SOUZA, BEATRIZ DI BOARETO NASTARI, RODRIGO BARBOSA DE SOUZA
S-8
MEMBRANE NANOTUBES: MECHANISMS OF FORMATION AND
FUNCTIONS IN CELLS BRUNO PONTES, NATHAN BESSA VIANA, YARENI AYALA,
ANNA CAROLINA CARVALHO DA FONSECA, LUCIANA FERREIRA ROMÃO, RACKELE
FERREIRA AMARAL, LEONARDO TAVARES SALGADO, FLÁVIA REGINA DE SOUZA
LIMA, LORAINE CAMPANATI, MARCOS FARINA, VIVALDO MOURA NETO, H.
MOYSES NUSSENZVEIG
S-9
MORPHOLOGICAL AND ULTRASTRUCTURAL STUDY OF SALIVARY
GLAND OF TRIATOMA INFESTANS (HEMIPTERA, TRIATOMINAE) NADJA BIONDINE
MARRIEL, PAULO FILEMON PAOLUCCI PIMENTA, ANA CAROLINA BORELLA ANHÊ
S - 10
EVALUATION OF THE TOXICITY OF THALIDOMIDE INCORPORATED
IN BIODEGRADABLE IMPLANTS PEDRO ALCANTARA FONSECA DE SOUZA, SÍLVIA
LIGÓRIO FIALHO, ARMANDO SILVA-CUNHA, LUCIANA MARIA SILVA
S - 11
IDENTIFICATION
AND
EVALUATION
OF
BIOLOGICAL
CONSERVATION OF DIFFERENT TOXINS FROM BROWN SPIDER VENOM
(LOXOSCELES GENUS) IN THREE SPECIES OF GREATER IMPACT ON PARANÁ: L.
INTERMEDIA, L. LAETA AND L. GAUCHO FERNANDA NUNES SOUZA, DANIELA
REGINA BUCH, GABRIEL OTTO MEISSNER, DILZA TREVISAN SILVA, MÁRCIA HELENA
APPEL, RAFAEL BERTONI DA SILVEIRA, DANIELE CHAVES MOREIRA, LUIZA HELENA
GREMSKI, ANDREA SENFF-RIBEIRO, OLGA MEIRI CHAIM, SILVIO SANCHES VEIGA
S - 12
CONSTRUCTION OF A CDNA LIBRARY FOR ANTIMICROBIAL
PEPTIDES FROM HYPSIBOAS SEMILINEATUS LORENA NACIF MARÇAL, MONISE
VIANA ABRANCHES, GRACIELLE RODRIGUES PEREIRA, NATÁLIA CRISTINA SANTOS
COSTA, HELIOMAR CAZELLI DE OLIVEIRA FILHO, RENATO NEVES FEIO, EDUARDO
RESENDE HONDA, SÉRGIO OLIVEIRA DE PAULA, LEANDRO LICURSI DE OLIVEIRA
S - 13
DEVELOPMENT OF A BIOENGINEERED HUMAN-SKIN CHICK
EMBRYO MODEL FOR TESTING DRUGS FOR SKIN INFLAMMATORY DISORDERS
KAREN JACKSON, ROTEM BEN SHUSHAN, HILA YEHUDA, LEONID KOGAN, SNAIT
TAMIR
S - 14
ATOMIC FORCE MICROSCOPY AS A TOOL TO STUDY THE
MITOCHONDRIAL DNA OF TRYPANOSOMATIDS MARCELO ZOGOVICH, DANIELA
LEÃO GONÇALVES, LILIAN TEREZINHA COSTA, WANDERLEY DE SOUZA, DANIELLE
PEREIRA CAVALCANTI
S - 15
UNRAVELING OPTIMIZED CONDITIONS FOR CARTILAGE TISSUE
ENGINEERING USING THREE-DIMENSIONAL HIGH-DENSITY HUMAN STEM CELL
S - 20
EVALUATION OF DIFFERENT METHODOLOGIES TO ACHIEVE
EFFICIENT EXPRESSION OF THE DENGUE VIRUS NS1 PROTEIN IN HEPG2 CELLS
KÍSSILA RABELO, EDSON ROBERTO ALVES DE OLIVEIRA, ADA MARIA DE BARCELOS
ALVES, SIMONE MORAIS DA COSTA
S - 21
MEASUREMENT OF PROTEIN DISULFIDE ISOMERASE REDUCTASE
ACTIVITY IN BIOLOGICAL SAMPLES BY INSULIN ASSAY DENISE DE CASTRO
FERNANDES, MONICA MASSAKO WATANABE, FRANCISCO RAFAEL MARTINS
LAURINDO
S - 22
OBTENTION OF 3D SPHEROIDAL CULTURE FROM MC3T3-E1
MURINE PRE-OSTEOBLASTIC CELLS FOR BIOCOMPATIBILITY STUDIES EMANUELLE
STELLET LOURENÇO, ROBER FREITAS BACHINSKI, ADRIANA BRANDÃO RIBEIRO
LINHARES, JOSÉ MAURO GRANJEIRO, GUTEMBERG GOMES ALVES
S - 23
PREDICTION OF ACUTE TOXICITY OF A MEDICINAL PLANT
CASEARIA SYLVESTRIS FLUID EXTRACT BY IN VITRO MODEL ALINE ZANCHETI
AMENI, ANDREA CECILIA DORION RODAS, SILVANA LIMA GÓRNIAK
S - 24
CRYO-SCANNING ELECTRON MICROSCOPY FOR THE ADVANCED
STUDY OF CRYO-FIXED AND HYDRATED SAMPLES. RENATA TRAVASSOS,
EDUARDO JOSÉ LOPES TORRES, KILDARE MIRANDA, MÁRCIA ATTIAS
S - 25
BACTERIAL CELL CULTURE IMPROVEMENT AIMING THE
PRODUCTION OF CISTINE KNOT FAMILY PEPTIDE FROM BROWN SPIDER
(LOXOSCELES INTERMEDIA) VENOM GABRIEL OTTO MEISSNER, FENADO H.
MATSUBARA, ALINE VIANA BEDNASKI, EDUARDO MENDONÇA, LUCAS PEDROSA,
LUIZA HELENA GREMSKI, SILVIO SANCHES VEIGA, OLGA MEIRI CHAIM
S - 26
IMMUNE CELL CULTURE IN TROPICAL SEA URCHIN LYTECHINUS
VARIEGATUS PAOLA CRISTINA BRANCO, DOUGLAS AMARAL DOS SANTOS,
DÉBORA ALVARES LEITE FIGUEIREDO, JOSÉ ROBERTO MACHADO CUNHA DA SILVA
S - 27
STANDARDIZATION OF COMET ASSAY WITH DAPHNIA MAGNA
STRAUS (1820) FERNANDA FLEIG ZENKNER, CAMILA GONÇALVES ATHANÁSIO,
JOEL HENRIQUE ELLWANGER, DANIEL PRÁ, EDUARDO ALEXIS LOBO, ALEXANDRE
RIEGER
S - 28
EVALUATION OF THE IN VIVO CROSS LINKING METHOD FOR
LEISHMANIA BRAZILIENSIS TO OBTAIN COMPLEXES WITH OTUBAIN, A
DEUBIQUITYLATING ENZYME CLENIA DOS SANTOS AZEVEDO, JULIANA ARAUJO
CARNEIRO, JHONATA LIMA PEREIRA, FLAVIA NADER MOTTA ARENAS, JAIME
MARTINS DE SANTANA, IZABELA MARQUES DOURADO BASTOS
S - 29
CORRELATIVE MICROSCOPY WITH ‘SHUTTLE & FIND’ – COMBINING
THE POWER OF IMAGING DEVICES. JENS MARKUS RIETDORF
S - 30
ULTRASTRUCTURAL ANALYSIS OF THE MYCELIUM OF
DEMATIACEOUS MOLD CURVULARIA SP UNDER THE ACTION OF THE
ANTIFUNGAL AGENT AMPHOTERICIN B ADRIANO BIANCALANA, FERNANDA
SIMAS CORRÊA BIANCALANA, LUZIA LYRA, ANGÉLICA ZANINELLI SCREIBER
T – Neurobiology
T1-T85
T-1
EFFECTS OF VENOUS ANESTHETIC ETOMIDATE ON SYNAPTIC
VESICLE EXOCYTOSIS AT THE MICE NEUROMUSCULAR JUNCTION PRISCILA
APARECIDA COSTA VALADÃO, CRISTINA GUATIMOSIM FONSECA, JANICE
HENRIQUES DA SILVA, RENATO SANTIAGO GOMEZ
117
T-2
OPTICAL AND ULTRASTRUCTURAL ANALYSIS OF NEUROMUSCULAR
JUNCTIONS FROM DIAPHRAGMS OF MICE WITH CHOLINERGIC DYSFUNCTION
HERMANN ALECSANDRO RODRIGUES, MATHEUS DE CASTRO FONSECA, PATRÍCIA
MASSARA MARTINELLI, PATRÍCIA MARIA D'ALMEIDA LIMA, VÂNIA FERREIRA
PRADO, MARCO ANTÔNIO MÁXIMO PRADO, CRISTINA GUATIMOSIM FONSECA
T-3
EFFECTS OF INHALATORY ANESTHETIC SEVOFLURANE ON
SYNAPTIC VESICLE EXOCYTOSIS AT THE MOUSE NEUROMUSCULAR JUNCTION
MATHEUS DE CASTRO FONSECA, JANICE HENRIQUES DA SILVA, RENATO SANTIAGO
GOMEZ, CRISTINA GUATIMOSIM
T-4
EFFECT OF UVA AND UVB ON THE EXPRESSION OF SEROTONIN IN
THE CENTRAL OLFACTORY SYSTEM OF THE CRAB UCIDES CORDATUS. GABRIELLE
DE JESUS FERREIRA, GABRIELA HOLLMANN, ÁLVARO LEITÃO, SILVANA ALLODI
T-5
INCREASE IN PROPORTION OF SUBSTANCE P NERVE FIBERS IN
INDIVIDUALS WITH CHAGASIC MEGAESOPHAGUS RODOLFO DUARTE
NASCIMENTO, PATRÍCIA ROCHA MARTINS, JACQUELINE GARCIA DUARTE, DÉBORA
D’ÀVILA REIS
T-6
RELATION BETWEEN THE AREA OF GFAP ENTERIC GLIAL CELLS AND
THE NUMBER OF NEURONS IN ESOPHAGUS OF CHAGASIC INDIVIDUALS
RODOLFO DUARTE NASCIMENTO, PATRÍCIA ROCHA MARTINS, JACQUELINE
GARCIA DUARTE, DÉBORA D’ÀVILA REIS
T-7
LOSS OF INTERSTITIIAL CELLS OF CAJAL MIGHT PRECEED
DENERVATION PROCESS IN CHRONIC TRYPANOSOMA CRUZI INFECTION PATRÍCIA
ROCHA MARTINS, RODOLFO DUARTE NASCIMENTO, JACQUELINE GARCIA DUARTE,
SHEILA ADAD, DÉBORA D’ÀVILA REIS
T-8
DENDRITIC SPINES IN THE MEPD OF RATS: MORPHOLOGY AND
CONNECTIVITY DALPIAN, F., BRUSCO, J., MOREIRA J.E., RASIA-FILHO, A.
T-9
ATP CONTROLS PROLIFERATION IN VIVO OF RAT RETINAL
PROGENITORS LUANA DE ALMEIDA PEREIRA, ALFRED FRANCO SHOLL, ANA LUCIA
MARQUES VENTURA, LUCIANNE FRAGEL MADEIRA
T - 10
MOLECULAR TOOLS TO ANALISYS OF HUNTINGTON’S DISEASE
HAPLOTYPES (CAG/CCG TRINUCLEOTIDE REPEATS) ON HTT GENE IN BRAZILIAN
PATIENTS LUCIANA DE ANDRADE AGOSTINHO, CATIELLY FERREIRA ROCHA,
ENRIQUE MEDINA-ACOSTA, HAZEL NUNES BARBOZA, ANTONIO FRANCISCO ALVES
DA SILVA, SIMÃO PEDRO FERNANDES PEREIRA, EDUARDO RIBEIRO PARADELA,
ANDRÉ LUIS DOS SANTOS FIGUEIREDO, EDUARDO DE MATOS NOGUEIRA, REGINA
MARIA PAPAIS ALVARENGA, SUELY RODRIGUES DOS SANTOS, CARMEN LUCIA
ANTÃO PAIVA
T - 11
VIRAL ENCEPHALITIS INDUCED BY DENGUE VIRUS IN ALBINO
SWISS MICE: THE INFLAMMATORY RESPONSE IN NEONATE’S NERVOUS SYSTEM
GIOVANNI FREITAS GOMES, MAIRA CATHERINE PEREIRA TURIEL, CÉSAR AUGUSTO
RAIOL FORO, BRUNNO GOMES PINHO, CARLA MAISA DAMASCENO REGO, MARINA
CUTRIM MAGALHAES, PEDRO FERNANDO DA COSTA VASCONCELOS, CRISTOVAM
WANDERLEY PICANÇO DINIZ
T - 12
PARKINSON`S DISEASE AND CEREBELLUM: NEW WAY OF
ANALYZING THE BRAIN LESIONS BY A PARAQUAT-INDUCED CLASSICAL
EXPERIMENTAL MODEL JOEL HENRIQUE ELLWANGER, FERNANDA FLEIG ZENKNER,
JULIANO ASSMANN, DANIEL PRÁ, MICHELE GASSEN KELLERMANN, ALEXANDRE
RIEGER, JOÃO ANTONIO PÊGAS HENRIQUES, DEIVIS DE CAMPOS
T - 13
EXPRESSION OF ALPHA SYNUCLEIN AND HIPERPHOSPHORYLATION
OF TAU IN THE BRAIN OF AGED RATS EXPOSED TO LOW CONCENTRATIONS OF
ROTENONE CAROLLINY MOURA DA SILVA, MICHAEL FERNANDES DE ALMEIDA,
MERARI DE FÁTIMA RAMIRES FERRARI
T - 14
EFFECT OF PROPOFOL ON ACETYLCHOLINE RELEASE IN RAT
HIPPOCAMPUS SYNAPTOSOMES FLÁVIA LAGE PESSOA DA COSTA, NANCY
SCARDUA BINDA, LUANNA DA SILVA MONTEIRO, RENATO SANTIAGO GOMEZ,
MARCUS VINÍCIUS GOMEZ
T - 15
SYNAPTIC CHANGES IN THE CORTEX OF INDIVIDUALS WITH
MESIAL TEMPORAL LOBE EPILEPSY ALONG AGING: LIPOFUSCIN GRANULES AS
MARKERS OF AGE SUÉLEN MERLO, ANA BEATRIZ NAKAYAMA, JANAINA BRUSCO,
MARCOS ANTÔNIO ROSSI, CARLOS GILBERTO CARLOTTI JÚNIOR, JORGE EDUARDO
MOREIRA
T - 16
NEUROGENESIS AND SYNAPTIC PLASTICITY IN RATS SUBMITTED
TO MATERNAL SEPARATION AND ENRICHED ENVIRONMENT SUÉLEN MERLO,
JOSÉ INÁCIO LEMOS, LENALDO BRANCO ROCHA, MARCOS ANTÔNIO ROSSI, JORGE
EDUARDO MOREIRA
T - 17
CONSTANT EXPRESSION OF ALFA-SINUCLEIN AND UBIQUITIN
ALONG AGING IN THE CORTEX OF INDIVIDUALS WITH MESIAL TEMPORAL LOBE
EPILEPSY ANA BEATRIZ SOUZA NAKAYAMA, SUÉLEN MERLO, JANAÍNA BRUSCO,
MARCOS ANTÔNIO ROSSI, CARLOS GILBERTO CARLOTTI JR, JORGE EDUARDO
MOREIRA
T - 18
MORPHOMETRIC ANALYSIS OF SOLEUS AND TRICEPS BRACHII
SKELETAL MUSCLES OF MICE WITH CHOLINERGIC DYSFUNCTION MATHEUS
PROENÇA SIMÃO MAGALHÃES GOMES, HERMANN ALECSANDRO RODRIGUES,
PATRÍCIA MASSARA MARTINELLI, VANIA FERREIRA PRADO, MARCO ANTÔNIO
MÁXIMO PRADO, CRISTINA GUATIMOSIM FONSECA
T - 19
EFFECT OF CONDITIONED MEDIUM FROM CULTURES OF
OLFACTORY ENSHEATHING GLIA ON HIPPOCAMPAL NEURAL CELLS IN VITRO.
LITIA ALVES DE CARVALHO, ROBERTA PEREIRA DE MELO GUIMARÃES, RICARDO
AUGUSTO DE MELO REIS, LENY ALVES CAVALCANTE
T - 20
FOOD RESTRICTION DOES NOT INTERFERE IN AGE-RELATED LOSS
OF GLIA AND CHOLINERGIC MYENTERIC NEURONS JOÃO PAULO FERREIRA
SCHOFFEN, JONATAS DE PAULA OLIVEIRA, ANA PAULA DE SANTI RAMPAZZO,
CARLA POSSANI CIRILO, MARIANA CRISTINA VICENTE UMADA ZAPATER,
FERNANDO AUGUSTO VICENTINI, ANACHARIS BABETO DE SÁ-NAKANISHI,
JURANDIR FERNANDO COMAR, MARIA RAQUEL MARÇAL NATALI
T - 21
IMPOVERISHED ENVIRONMENT AND REDUCED MASTICATORY
ACTIVITY AGGRAVATE AGING SPATIAL MEMORY DECLINE IN ALBINO SWISS MICE
ALBERT LUIZ COSTA DA COSTA, FABÍOLA DE CARVALHO CHAVES DE SIQUEIRA
MENDES, MARINA NEGRÃO FROTA DE ALMEIDA, ANDRÉ PINHEIRO GURGEL
FELÍCIO, MANOELA FALSONI, MARCIA LORENA FERREIRA DE ANDRADE;, JOÃO
BENTO TORRES NETO;, CRISTOVAM WANDERLEY PICANÇO-DINIZ;, MARCIA
CONSENTINO KRONKA SOSTHENES.
T - 22
WALLERIAN DEGENERATION IN GALECTIN-3 KNOCKOUT MICE
BRUNO DE SIQUEIRA MIETTO, SOFIA JURGENSEN HARTKE, LUCINÉIA ALVES,
MARCELO SAMPAIO NARCISO, IRANAIA ASSUNÇÃO MIRANDA, DEA MARIA SERRA
VILLA-VERDE, FLÁVIA REGINA SOUZA LIMA, MARCELO TORRES BOZZA, ANA MARIA
BLANCO MARTINEZ
T - 23
ACTIVATION OF AKT1 PROTEIN BY ALLOSTERIC MODULATORS OF
GLUTAMATE METABOTROPIC RECEPTOR 5 IN PRIMARY CULTURE OF STRIATAL
NEURONS FLAVIA RODRIGUES SILVA, FABIOLA MARA RIBEIRO, JULIANA
GUIMARÃES DÓRIA, JÉSSICA MABELLE DE SOUZA, HELTON JOSÉ DOS REIS, TOMAS
DOBRANSKY
T - 24
HYPOTHALAMIC AND CORTICAL ASTROCYTES RESPOND
DIFFERENTLY TO THE ADDITION OF FATTY ACID IN VITRO ÉRICA VIEIRA DOS
SANTOS, PEDRO AUGUSTO SILVA NOGUEIRA, RENATA GRACIELE ZANON
T - 25
OPTICAL ANALYSIS OF NEUROMUSCULAR JUNCTIONS OF
DIAPHRAGM MUSCLE FROM A TRANSGENIC MICE MODEL FOR HUNTINGTON’S
DISEASE BÁRBARA CAMPOS DE ARAGÃO, HERMANN ALECSANDRO RODRIGUES,
FABÍOLA MARA RIBEIRO, CRISTINA GUATIMOSIM FONSECA
T - 26
MASTICATORY REHABILITATION IMPROVES MICE EPISODIC-LIKE
MEMORY ANA CARLA FADEL, ANDRÉ PINHEIRO GURGEL FELÍCIO, FABÍOLA DE
CARVALHO CHAVES DE SIQUEIRA MENDES, RAÍSSA AIRES RIBEIRO BRINGEL,
RODRIGO PEREZ DA SILVA, KÁTIA DE AVIZ FONSECA, JOSÉ FERNANDO CARNEIRO
JUNIOR, ANTÔNIO LUIZ BREIA DA SILVA JUNIOR, CRISTOVAM WANDERLEY
PICANÇO DINIZ, MARCIA CONSENTINO KRONKA SOSTHENES
T - 27
ASPECTS OF DEGENERATION AND REGENERATION OF THE STYELA
PLICATA NEURAL COMPLEX INDUCED BY 3-ACETYLPYRIDINE BIANCA NICOLE
SANTOS PAEZ MEDINA, ISADORA SANTOS DE ABREU, SILVANA ALLODI, RODRIGO
NUNES DA FONSECA, CÍNTIA MONTEIRO DE BARROS
T - 28
ASSESSMENT CELLULAR AFTER SPINAL CORD INJURY IN RAT:
CORRELATION WITH FUNCTIONAL RECOVERY ANDRÉA MARINS DAMASCENO
BOMFIM, JASON ROBBERT POTAS, NEWTON GONÇALVES DE CASTRO, ROSÁLIA
MENDEZ-OTERO
T - 29
DECREASE OF AUTOPHAGY AFTER ROTENONE EXPOSURE IN
CULTURED CELLS. LUANA DE SANTANA BOTTAS, MERARI DE FÁTIMA RAMIRES
FERRARI
T - 30
EFFECT OF CHRONIC ADMINISTRATION OF CAFFEINE ON MAP2
AND SYNAPTOPHYSIN IN HIPPOCAMPUS OF MALE AND FEMALE RATS LETICIA
FERREIRA PETTENUZZO, CARINA DE SOUZA MOTA, CARLA DALMAZ
T - 31
SICKNESS BEHAVIOR AND MICROGLIAL CHANGES IN THE DENTATE
GYRUS OF ADULT MICE (MUS MUSCULUS) AFTER INJECTION OF
LIPOPOLYSACCHARIDE (LPS) OF SALMONELLA ENTERIC THAIS BARROSO NAVES,
ANA CARLA FADEL, DANIEL GUERREIRO DINIZ, GIOVANNI FREITAS GOMES,
GRAZIELLA DE ASSIS MALERBA, ANA MARIA MATOS DE OLIVEIRA ROSSY, BRUNA
DO SOCORRO AMORIM DE LIMA, CARMEN DOS SANTOS FERNANDES, EDIANE
BARROS DA SILVA, EDUARDO AUGUSTO CRUZ DA SILVA, LUCIANO DE SENA
ARAUJO, MARIA DAS GRAÇAS REIS, ROSIGLEIDE GOMES DOS SANTOS, SUZANE
SANTOS CORREA, ZAIRA MONIK NUNES BARROS, CRISTOVAM WANDERLEY
PICANÇO DINIZ, CRISTOVAM WANDERLEY PICANÇO DINIZ
T - 32
INVESTIGATION OF THE METABOTROPIC RECEPTOR 5 ROLE IN
HYPERKINESIS USING A MICE MODEL OF HUNTINGTON’S DISEASE ISABELLA
MONTEIRO GUIMARÃES, FABIOLA MARA RIBEIRO, RITA G. W. PIRES, TOMAS
DOBRANSKY
T - 33
PRION PROTEIN MUTATIONS ASSOCIATED WITH PRION DISEASES
IMPAIR DIFFERENTIATION INDUCED BY LAMININ CLEITON FAGUNDES MACHADO,
FLAVIO H. BERALDO, TIAGO G. SANTOS, DOMINIQUE BOURGEON, MICHELE C.
LANDEMBERGER, VILMA R. MARTINS
T - 34
FLAVONOIDS
PROMOTES
NEURONAL
SURVIVAL
AND
SYNAPTOGENESIS IN CEREBRAL CORTEX IN VITRO ISADORA CRISTINA PEREIRA
MATIAS, JOICE STIPURSKY, FLÁVIA CARVALHO ALCÂNTARA GOMES
118
T - 35
STUDY OF PROTEIN CARBONYLS IN AGED RATS EXPOSED TO LOW
DOSE OF ROTENONE MICHAEL FERNANDES DE ALMEIDA, CAROLLINY MOURA DA
SILVA, MERARI DE FÁTIMA RAMIRES FERRARI
MULTIVESICULAR BODIES HIANARA BUSTAMANTE, ANDRES RIVERA-DICTTER,
VIVIANA CAVIERES, ALEXIS GONZALEZ, VANESSA MUÑOZ, JUAN S. BONIFACINO,
GONZALO A. MARDONES, PATRICIA V. BURGOS
T - 36
SECRETION OF STRESS INSDUCIBLE PROTEIN 1 IN MICROVESICLES
BY ASTROCYTES GLAUCIA HAJJ, CAMILA ARANTES, MARCOS S. DIAS, ISABEL
PORTO-CARREIRO, MARTÍN ROFFÉ, MARCO M. A. PRADO, RAFAEL LINDEN, VILMA
R. MARTINS
T - 53
BLOOD-BRAIN BARRIER BREAKDOWN AND REPAIR FOLLOWING
GLIOTOXIC DRUG INJECTION IN THE BRAINSTEM OF STREPTOZOTOCIN-DIABETIC
RATS MARIA DE FÁTIMA MONTEIRO MARTINS, EDUARDO FERNANDES BONDAN
T - 37
IGF-I-INDUCED MODULATION OF THE (NA/K)-ATPASE ACTIVITY
DURING THE POSTNATAL DEVELOPMENT OF RAT RETINA SHEILA MATURANA
TEIXEIRA, ELIZABETH GIESTAL DE ARAUJO, LUIZ ROBERTO LEÃO FERREIRA
T - 38
MORPHOLOGICAL CHARACTERIZATION OF CARDIAC TISSUE FROM
A MOUSE MODEL OF CHOLINERGIC DYSFUNCTION MARINA VIVEIROS TRAJANO
CRUZ, HERMANN ALECSANDRO RODRIGUES, PATRÍCIA MASSARA MARTINELLI,
MARCO ANTÔNIO PRADO, VÂNIA FERREIRA PRADO, SILVIA GUATIMOSIM,
CRISTINA GUATIMOSIM
T - 39
LAMININ-Γ1 CHAIN AND STRESS INDUCIBLE PROTEIN 1
SYNERGISTICALLY MEDIATE PRPC-DEPENDENT AXONAL GROWTH VIA CA2+
MOBILIZATION IN DORSAL ROOT GANGLIA NEURONS TIAGO GOSS DOS SANTOS,
FLAVIO H BERALDO, GLAUCIA NM HAJJ, MARILENE H LOPES, FERNANDA CS
LUPINACCI, MARCO AM PRADO, VILMA R MARTINS
T - 40
SHIITAKE MUSHROOM (LENTINULA EDODES) DOES NOT CAUSE
COGNITIVE IMPAIRMENTS, BUT INDUCES DNA DAMAGE IN HIPPOCAMPAL CELLS
IN RATS PATRÍCIA MOLZ, JOEL HENRIQUE ELLWANGER, FERNANDA FLEIG
ZENKNER, MORGANA TONET MENDONÇA, DEIVIS DE CAMPOS, MARISA
TEREZINHA LOPES PUTZKE, DANIEL PRÁ, SILVIA ISABEL RECH FRANKE
T - 41
THE BRIGHT SIDE OF PRION PROTEIN IN ALZHEIMER’ DISEASE: THE
ROLE OF STRESS INDUCIBLE PROTEIN 1 AS A NEUROPROTECTIVE FACTOR.
BIANCA LUISE TEIXEIRA, PEDRO HIRATA, ANA PAULA SAMPAIO, JORDANO BRITOMOREIRA, SERGIO FERREIRA, MARCO PRADO, GLAUCIA HAJJ, VILMA R. MARTINS
T - 42
HIPPOCAMPAL CELL CULTURE EXPOSED TO LOW DOSES OF
ROTENONE EXHIBITED PROTEASOMAL ACTIVITY INHIBITION AND TAU
HYPERPHOSPHORYLATION IN ABSENCE OF PROTEIN CARBONYLATION. RODRIGO
DOS SANTOS CHAVES, MARILENE DEMASI, MERARI DE FATIMA RAMIRES FERRARI
T - 43
HIGH-FAT DIET CAUSES ENTERIC NEURONAL LOSS IN THE DISTAL
COLON OF MICE. EVANDRO JOSÉ BERALDI, LIA MARA TEOBALDO TIRONI,
ANGÉLICA SOARES, ROBERTO BARBOSA BAZOTTE, NILZA CRISTINA BUTTOW
T - 44
INCREASED HIPPOCAMPAL GFAP IN YOUNG RATS FROM ANIMAL
MODEL OF AUTISM INDUCED BY PRENATAL EXPOSURE TO VALPROIC ACID
ROBERTA BRISTOT SILVESTRIN, GIOVANA BROLESE, CRISTIANE BATASSINI, MÁRCIO
FERREIRA DUTRA, NÚBIA BROETTO CUNHA, CARLOS ALBERTO GONÇALVES,
CARMEM GOTTFRIED
T - 45
IL-4 REGULATES THE LEVELS OF M3 MUSCARININC RECEPTORS IN
RETINAL CELLS: THE ROLE OF IL-4 TYPE I RECEPTORS MARCELO GOMES GRANJA,
LUIS EDUARDO GOMES BRAGA, ALINE ARAUJOS DOS SANTOS RABELO, ELIZABETH
GIESTAL DE ARAUJO
T - 46
PROLONGED MATERNAL SEPARATION AFFECTS HIPPOCAMPAL
MORPHOLOGY AND NEUROTRANSMISSION ACCOMPANIED BY CHANGES IN
NUTRITION-RELATED HORMONAL LEVELS PRISCILA BRISENO FROTA, DAVI DA
CUNHA GONÇALVES, ANITA MAYARA FEITOSA SANTOS, CAMILA DE
ALBUQUERQUE ALMEIDA, CELINA VIANA DE ARAÚJO, EMMANUEL GONÇALVES DE
CASTRO ANDRADE, GEANNE M. DE ANDRADE, NUNO DE SOUSA, REINALDO
BARRETO ORIÁ
T - 47
THE PROTEIN CINASE C MODULATES THE CHOLINERGIC
PHENOTYPE: POSSIBLE INVOLVEMENT OF INTERLEUKINS LUIS EDUARDO GOMES
BRAGA, MARCELO GOMES GRANJA, ELIZABETH GIESTAL DE ARAUJO, ALINE
ARAUJO DOS SANTOS
T - 48
ENVIRONMENTAL
ENRICHMENT
REDUCES
ANXIETY-LIKE
BEHAVIOR ASSOCIATED WITH MASTICATORY DEPRIVATION IN ALBINO SWISS
MICE RAISSA AIRES RIBEIRO BRINGEL, ANDRÉ PINHEIRO GURGEL FELÍCIO, FABÍOLA
DE CARVALHO CHAVES DE SIQUEIRA MENDES, ALBERT LUIZ COSTA DA COSTA,
ANA CARLA FADEL, RODRIGO PEREZ DA SILVA, DIEGO DE JESUS SILVA, MARCIA
NUZANE AMORIM DE SOUZA, YANA MONTEZUMA SANTOS, CRISTOVAM
WANDERLEY PICANÇO DINIZ, MARCIA CONSETINO KRONKA SOSTHENES
T - 49
EVALUATION OF SOLVENTS AND CONTROLS FOR IN VITRO HUMAN
CELL-BASED NEUROTOXICOLOGICAL STUDIES LETÍCIA APARECIDA BARBOSA
HUMMEL, RÓBER BACHINSKI, ADRIANA BRANDÃO RIBEIRO LINHARES, JOSÉ
MAURO GRANJEIRO, GUTEMBERG GOMES ALVES
T - 50
INTERLEUKIN-2 (IL-2) AND RETINAL GANGLION CELL SURVIVAL:
SIGNALING PATHWAYS INVOLVED LUCIENNE DE OLIVEIRA JESUS SOUZA, REGINA
CÉLIA CUSSA KUBRUSLY, ELIZABETH GIESTAL DE ARAUJO
T - 54
DIABETES DECREASES ASTROCYTIC GFAP EXPRESSION AFTER
GLIOTOXIC LESION IN THE RAT BRAINSTEM EDUARDO FERNANDES BONDAN,
MARIA DE FÁTIMA MONTEIRO MARTINS, FLÁVIO CESAR VIANI
T - 55
DETERMINATION OF L-DOPA ADMINISTRATION EFFECTS IN A
PARKINSON ANIMAL MODEL INDUCED BY 6-OHDA IGOR CARVALHO MARQUES,
JÚNIA VIEIRA DOS SANTOS, MARCOS ROMÁRIO MATOS DE SOUZA, RAFAELA
CARNEIRO CORDEIRO, LUCIANA DIAS BELCHIOR, ANDRÉ FÉRRER CARVALHO,
DANIELLE SILVEIRA MACEDO
T - 56
IN VITRO EFFECT OF AMPHETAMINE AND MINOCYCLINE IN THE
MITOCHONDRIAL ACTIVITY OF RAT’S CEREBRAL CORTEX RAFAELA CARNEIRO
CORDEIRO, IGOR CARVALHO MARQUES, CAMILA DANTAS MEDEIROS, JÚNIA
VIEIRA DOS SANTOS, DANIELLE SILVEIRA MACEDO, ANDRÉ FÉRRER CARVALHO
T - 57
MORPHOMETRIC EVALUATION AND IMMUNOFLUORESCENCE OF
NEURONS OF THE PERIPHERAL NOCICEPTIVE SYSTEM IN OFFSPRING OF DIABETIC
RATS TAÍS DE CAMPOS LIMA, CELINA MONTEIRO DA CRUZ LOTUFO
T - 58
EFFECTS OF DEPRESSION ASSOCIATED OR NOT WITH
ANTIDEPRESSANT TREATMENT ON THE RAT SALIVARY GLANDS PATRÍCIA HELENA
ZANIER-GOMES, CARINA CARRARO PESSOA, TOMAZ EUGÊNIO DE ABREU SILVA,
NANCI MENDES PINHEIRO, SIMONE DE SALES COSTA MOREIRA CARBONI, ADILHA
MISSON RUA MICHELETTI, VIRGÍNIA OLIVEIRA CREMA
T - 59
ASTROCYTES REGULATE GABAERGIC SYNAPSE FORMATION
THROUGH THE TGF-BETA SIGNALING. LUAN PEREIRA DINIZ, VANESSA TORTELLI,
LUCIANA FERREIRA ROMÃO, FLÁVIA CARVALHO ALCANTARA GOMES
T - 60
IN VIVO EXPOSURE TO CAFFEINE CHANGES THE EXPRESSION OF A1
AND A2A ADENOSINE RECEPTORS IN THE CHICK EMBRYO RETINA: POSSIBLE
EFFECTS ON THE GABAERGIC SYSTEM. RAFAEL BRITO DA SILVA, ROBERTO PAES DE
CARVALHO, KARIN DA COSTA CALAZA
T - 61
BEHAVIOR AND NEUROCHEMICAL ALTERATIONS RELATED TO
CHRONIC ADMINISTRATION OF ETHANOL AND STRESS EXPOSURE DANIEL
MOREIRA SILVA, GESSYNGER MORAIS SILVA, JULIANA FERNANDES SANTOS,
MARCELO TADEU MARIN
T - 62
NEUROGENIC NICHE OF ADULT BRAIN: ULTRASTRUCTURAL
ASPECTS OF CELL ELEMENTS IN SUBVENTRICULAR ZONE, IN LONG-EVANS RATS
CARLOS ALEXANDRE DOS SANTOS HAEMMERLE, SILVIA HONDA TAKADA, LEILA
GUISSONI CAMPOS, MARIA INÊS NOGUEIRA, II-SEI WATANABE
T - 63
INVESTIGATION OF SYNAPTIC DEFICITS IN SEPSIS: ROLE OF GLIAL
CELLS CAROLINA ARAUJO MORAES, TÂNIA SPOHR, GABRIEL SANTOS, JOANA
D’AVILLA, FERNANDO AUGUSTO BOZZA, FLÁVIA REGINA SOUZA LIMA, CLAUDIA
BENJAMIM, FLÁVIA CARVALHO ALCANTARA GOMES
T - 64
THE TROPHIC EFFECT OF IL-4 ON RETINAL GANGLION CELLS
INVOLVES AN INCREASE IN BDNF EXPRESSION ALINE ARAUJO DOS SANTOS,
ELIZABETH GIESTAL DE ARAUJO, ELIZABETH GIESTAL DE ARAUJO
T - 65
STRESS IN PRE-PUBERTAL PERIOD AND CHRONIC EXPOSURE TO
PALATABLE DIETS – EVALUATION OF PARAMETERS OF OXIDATIVE STRESS IN THE
HIPPOCAMPUS OF ADULT MALE RATS. DANUSA MAR ARCEGO, CARINE LAMPERT,
RACHEL KROLOW, CRISTIE NOSCHANG, TAMIRES BEN, ANA PAULA TONIAZZO,
CARLA DALMAZ
T - 66
EFFECT OF CHRONIC ADMINISTRATION OF TAMOXIFEN AND/OR
ESTRADIOL ON OXIDATIVE PARAMETERS IN BRAIN OF OVARIECTOMIZED RATS
CARINE LAMPERT, DANUSA MAR ARCEGO, RACHEL KROLOW, CRISTIE NOSCHANG,
DANIELA PEREIRA LAUREANO, ISADORA FERREIRA LIMA, LUISA AMÁLIA DIEHL,
CARLA DALMAZ, LETÍCIA FERREIRA PETTENUZZO, DEUSA VENDITE
T - 67
NEUROPROTECTIVE EFFECT OF THE METABOTROPIC GLUTAMATE
RECEPTOR 5 POSITIVE ALLOSTERIC MODULATORS IN HUNTINGTON´S DISEASE
JULIANA GUIMARÃES DÓRIA, VANESSA COSTA DE MIRANDA DRUMMOND, FLAVIA
RODRIGUES SILVA, TOMAS DOBRANSKY, FABIOLA MARA RIBEIRO
T - 68
PHARMACOLOGICAL EFFECT OF BRAZILIAN SPIDER OMEGATOXINS IN CALCIUM SIGNALING OF TRIGEMINAL NOCICEPTIVE PATHWAY
ELIZETE MARIA RITA PEREIRA, CÉLIO JOSÉ DE CASTRO JÚNIOR, ALESSANDRA
HUBNER DE SOUZA, NANCY SCARDUA BINDA, LUCIENE BRUNO VIEIRA, RICARDO
SANTIAGO GOMEZ, MARCUS VINICIUS GOMEZ
T - 51
THE MECHANISMS OF STI1 (STRESS INDUCIBLE PROTEIN 1 )
SECRETION BY ASTROCYTES. MARCOS VINICIOS SALLES DIAS, GLAUCIA N. M. HAJJ,
VILMA R. MARTINS
T - 69
NEURONAL DIFFERENTIATION OF HUMAN NEUROBLASTOMA CELL
LINE SH-SY5Y AND ITS USE FOR NEUROSCIENCE RESEARCH FERNANDA MARTINS
LOPES, GIOVANA FERREIRA LONDERO, LIANDA MARENGO DE MEDEIROS,
ROSALVA THEREZA MEURER, GADRIELA DELEVATI COLPO, MARILDA DA CRUZ
FERNANDES, FLAVIO KAPCZINSKI, FÁBIO KLAMT
T - 52
TURNOVER OF BETA-AMYLOID PRECURSOR PROTEIN IS
REGULATED BY TWO MECHANISMS AT THE PLASMA MEMBRANE: THE
UBIQUITIN-PROTEASOME
PATHWAY
AND
INCORPORATION
INTO
T - 70
SYNAPTIC CONTACTS ON DENDRITIC SPINES OF THE
POSTERODORSAL MEDIAL AMYGDALA OF RATS JORGE E. MOREIRA, ALBERTO A.
RASIA-FILHO, RONALD PETRALIA, BECHARA KACHAR, JORGE E. MOREIRA
119
T - 71
LATERALIZATION OF INHIBITORY SYNAPTIC CONTACTS IN THE
POSTERODORSAL MEDIAL AMYGDALA OF RATS JORGE E. MOREIRA, JANAINA
BRUSCO, SUÉLEN MERLO, ALBERTO A. RASIA-FILHO, JORGE E. MOREIRA
U-2
MORPHOLOGICAL ANALYSIS OF MIMOSA HOSTILIS BENTH SEEDS
BY CYTOCHEMICAL METHODS. RENAN DA SILVA SANTOS, DEBORAH ALANI DE
OLIVEIRA, MARIA IZABEL GALLÃO
T - 72
THYROID
HORMONES
MEDIATE
NEURON-ASTROCYTE
INTERACTIONS: ROLE OF HEPARAN SULPHATE PROTEOGLYCANS ROMULO
SPERDUTO DEZONNE, JOICE STIPURSKY, ANA PAULA BERGAMO ARAUJO, JADER
NONES, MAURO SÉRGIO GONÇALVES PAVÃO, MARIMÉLIA PORCIONATTO, FLÁVIA
CARVALHO ALCANTARA GOMES
U-3
MORPHOLOGICAL ANALYSIS OF BAUHINIA FOFICATA, LIN SEEDS
ARYELLI MAGALHÃES MACIEL, GABRIELA RODRIGUES FARIAS, GLEICYANNE VIEIRA
DA COSTA, MARIA IZABEL GALLÃO
T - 73
EFFECTS OF MATERNAL NICOTINE EXPOSURE DURING LACTATION
ON HYPOTHALAMIC NEUROPEPTIDES EXPRESSION IN THE ADULT RAT CINTIA
RODRIGUES PINHEIRO, VIVIANE YOUNES-RAPOZO, EGBERTO G. MOURA, ALEX C.
MANHÃES, ANA PAULA SANTOS-SILVA, ELAINE DE OLIVEIRA, PATRICIA C. LISBOA
T - 74
EVIDENCE OF PRION PROTEIN-STRESS INDUCIBLE PROTEIN 1
INTERACTION IN THE NEUROBIOLOGY OF TUMOR STEM CELLS REBECA
PIATNICZKA IGLESIA, VILMA REGINA MARTINS, TIAGO GÓSS DOS SANTOS,
MARILENE HOHMUTH LOPES
T - 75
ENDOTHELIAL AND RADIAL GLIA CELLS INTERATION DURING
CEREBRAL CORTEX DEVELOPMENT DANIEL FRANCIS FRANCO, JOICE STIPURSKY,
FLÁVIA CARVALHO ALCANTARA GOMES
T - 76
ENRICHED ENVIRONMENT INDUCES HIPPOCAMPUS CELLULAR
PLASTICITY IN TYPE 1 DIABETIC RATS FRANCELE VALENTE PIAZZA, ETHIANE
SEGABINAZI, LÍGIA ALINE CENTENARO, PATRÍCIA SEVERO DO NASCIMENTO,
MATILDE ACHAVAL, SIMONE MARCUZZO
T - 77
EFFECTS OF ENVIRONMENTAL ENRICHMENT ON MOTOR
FUNCTIONS AND MUSCLE MORPHOLOGY ALTERATIONS IN A CEREBRAL PALSY
RODENT MODEL MARÍLIA ROSSATO MARQUES, FELIPE DE SOUZA STIGGER,
BRUNO SANTOS CAMPOS GOMES, ETHIANE SEGABINAZI, FRANCELE VALENTE
PIAZZA, SÍLVIA BARBOSA, MATILDE ACHAVAL, SIMONE MARCUZZO
T - 78
ENRICHED ENVIRONMENT PREVENTS MEMORY DEFICITS BUT NOT
REVERT HIPPOCAMPUS CELLULAR SURVIVAL IN TYPE 1 DIABETIC RATS FRANCELE
VALENTE PIAZZA, ETHIANE SEGABINAZI, LÍGIA ALINE CENTENARO, PATRÍCIA
SEVERO DO NASCIMENTO, MATILDE ACHAVAL, SIMONE MARCUZZO
T - 79
MATERNAL PROLACTIN INHIBITION DURING LATE-LACTATION IS
ASSOCIATED WITH HIGHER NEUROPEPTIDE Y (NPY) IN ARCUATE NUCLEUS AND
IN PARAVENTRICULAR NUCLEUS IN PROGENY AT ADULTHOOD VIVIANE RAPOZOYOUNES, NAYARA PEIXOTO-SILVA, LIGIA DE ALBUQUERQUE MAIA, ALEX C.
MANHÃES, EGBERTO GASPAR DE MOURA, ELAINE DE OLIVEIRA, PATRICIA
CRISTINA LISBOA
T - 80
PI3K/AKT PATHWAY REGULATES MITOSIS OF NEURAL
PROGENITORS DURING RETINAL DEVELOPMENT ISIS MORAES ORNELAS,
THAYANE MARTINS SILVA, LUCIANNE FRAGEL MADEIRA, ANA LÚCIA MARQUES
VENTURA
T - 81
ACTIVATION OF P2X7 RECEPTORS INHIBITS THE PROLIFERATION
OF LATE DEVELOPING RETINAL PROGENITORS IN CULTURE. THAYANE MARTINS
SILVA, ISIS MORAES ORNELAS, ROXANA MAMANI ANCCASI, ANA LÚCIA MARQUES
VENTURA
U-4
OBSERVATION OF SEED LIPIDS FROM NORTHEASTERN SEMI ARID
NATIVE SPECIES THROUGH THE NILE RED JOSÉ DE BRITO VIEIRA NETO, MARIA
IZABEL GALLÃO, ASSUERO SILVA MEIRA, BRUNO MARQUES SOARES
U-5
MORPHOLOGICA ANALYSIS OF CAESALPINIA PYRAMIDALIS TUL
SEEDS PAMELA CLEMENTE DE MENESES SILVA, STELAMARIS DE OLIVEIRA PAULA,
MARIA IZABEL GALLÃO
U-6
LIGHT MICROSCOPY AS A TOOL TO INVESTIGATE PRETREATMENT
EFFECT ON SUGARCANE RICARDO CHAVES VILELA, YURI ABUD, LILIAN T. COSTA,
WANDERLEY DE SOUZA, CELSO SANT’ANNA
U-7
EFFECTS OF ULTRAVIOLET RADIATION-B ON THE LEAF BLADE
ORYZA SATIVA L. (POACEAE) CV EPAGRI 108 (1): CHANGES IN ULTRASTRUCTURAL
ORGANIZATION. SÉRGIO LUIZ DE ALMEIDA, ÉDER CARLOS SCHMIDT, ANA
CLAUDIA RODRIGUES, ZENILDA LAURITA BOUZON
U-8
DETERMINATION OF THE MUTAGENESIS AND CYTOTOXIC
ETHANOLIC EXTRACT OF PLANTAGO MAJOR (TANSAGEM) HELEN TAIS DA ROSA,
TATIANE DA AQUINO, DINARA JAQUELINE MOURA
U-9
MORPHOLOGICAL ANALYSIS OF ARTOCARPUS HETEROPHYLLUS
LAM SEEDS GABRIELA ARAÚJO DE ABREU, ALINE PESSOA NEGREIROS, MARIA
IZABEL GALLÃO
U - 10
MORPHOLOGICAL CHANGES OF IN NATURA MANGOES
SUBMITTED TO AN ELECTROLYZED WATER TREATMENT MARIA IZABEL GALLÃO,
MARIA EDILEUZA LEITE, EBENEZER DE OLIVEIRA SILVA
U - 11
MULTIPLICATION OF SOMATIC EMBRYOS OF BACTIS GASIPAES IN
TEMPORARY IMMERSION SYSTEM (TIS) ANGELO SCHUABB HERINGER, DOUGLAS
ANDRÉ STEINMACHER, MIGUEL PEDRO GUERRA
U - 12
MATURATION AND CONVERSION OF SOMATIC EMBRYOS OF
BACTRIS GASIPAES ANGELO SCHUABB HERINGER, DOUGLAS ANDRÉ
STEINMACHER, MIGUEL PEDRO GUERRA
U - 13
MORPHOLOGICAL AND HISTOCHEMICAL STUDY OF GREEN ALGAE
(CLADOPHORA SP AND ULVA LACTUCA) TREATED WITH DIFFERENT SALINITIES
LUZ KARIME POLO OSORIO, ÉDER C. SCHMIDT, CLAUDIANE GOUVEIA,
MARTHIELLEN R. L. FELIX, FUNGYI CHOW, CRISTINA NASSAR, ZENILDA L. BOUZON
U - 14
CHANGES IN THE MORPHOLOGY AND ULTRASTRUCTURE INDUCED
BY ULTRAVIOLET RADIATION-B IN THE CARRAGENOPHYTE HYPNEA
MUSCIFORMIS (RHODOPHYTA, GIGARTINALES) EDER CARLOS SCHMIDT, BEATRIZ
PEREIRA, RODRIGO W. DOS SANTOS, CLAUDIANE GOUVEIA, FERNANDA RAMLOV,
MARCELO MARASCHIN, ZENILDA L. BOUZON
T - 82
ANALYSIS OF THE LIPID COMPOSITION OF THE ADULT MURINE
BRAIN CEREBROSPINAL FLUID MARÍLIA KIMIE SHIMABUKURO, THAIS DE BARROS
FERNANDES, GEÓRGIA CORREA ATELLA, CLAUDIA M.C. BATISTA, VALÉRIA DE
MELLO-COELHO
U - 15
MORPHOLOGICAL AND CELLULAR CHARACTERIZATION OF
ZYGOTIC POLYEMBRYOS IN ARAUCARIA ANGUSTIFOLIA (BERT.) O. KUNTZE
GLADYS DANIELA ROGGE RENNER, NEUSA STEINER, ÉDER CARLOS SCHMIDT,
ZENILDA LAURITA BOUZON, FRANCINE LUNARDI FARIAS, MARIA LUIZA TOMAZI
PEREIRA, MIGUEL PEDRO GUERRA
T - 83
PRELIMINARY STUDIES OF CELL VIABILITY AND OXIDATIVE STRESS
AFTER TREATMENT WITH NICOTINE OR VARENICLINE ON NEURONAL
HIPPOCAMPAL PRIMARY CULTURES RAPHAEL TRINDADE DOS SANTOS, VIVIANE
YOUNES RAPOZO, CLÁUDIO CARNEIRO FILGUEIRAS, YAEL ABREU VILLAÇA, ALEX
CHRISTIAN MANHÃES
U - 16
CELLULAR ALTERATIONS IN THE AGAROPHYTE GRACILARIA
DOMINGENSIS TREATED WITH THE HEAVY METAL LEAD CLAUDIANE GOUVEIA,
MARIANNE KREUSCH, EDER C. SCHMIDT, RODRIGO W. DOS SANTOS, ZENILDA L.
BOUZON
T - 84
ROLE OF TGF-Β1 ON RADIAL GLIA CELLS DIFFERENTIATION:
REGULATION OF FOXG1 AND ERBB2 EXPRESSION. LAYS SOUZA DA SILVA, JOICE
STIPURSKY SILVA, FLÁVIA CARVALHO ALCANTARA GOMES
T85 HEPATOTOXIC (hCCP – MICROCYSTIN) AS WELL AS NON-HEPATOTOXIC
CYANOPEPTIDES (n-hCCP) INFLUENCE NESTIN AND GFAP INTERMEDIATE
FILAMENT ORGANIZATION IN ASTROCYTE
ANJA BUBIK1,2, ROBERT FRANGEŽ3, TAMARA T LAH1 AND BOJAN SEDMAK1,2
U – Plant Cell Biology
U1-U41
U-1
MORPHOLOGICAL
CHARACTERIZATION
OF
MIMOSA
CAESALPINIIFOLIA BENTH. SEED BY CYTOCHEMICAL METHODS RÔMULO
MESQUITA FRANCO, LUCIANA DE VASCONCELOS REBOUÇAS, RENAN DA SILVA
SANTOS, MARIA IZABEL GALLÃO
U - 17
EFFECTS OF CADMIUM ON THE MORPHOLOGY AND
CYTOCHEMISTRY OF THE RED MACROALGAE PTEROCLADIELLA CAPILLACEA
MARTHIELLEN ROOSEVELT DE LIMA FELIX, ÉDER C. SCHMIDT, LUZ K. P. OSORIO,
CLAUDIANE GOUVEIA, MARIANNE KREUSCH, RODRIGO DOS SANTOS, ZENILDA L.
BOUZON
U - 18
GLOBAL DNA METHYLATION LEVELS DURING ACCA SELLOWIANA
(O. BERG) BURRET SOMATIC EMBRYOGENESIS BY HIGH PERFORMANCE LIQUID
CHROMATOGRAPHY-MASS SPECTROMETRY HUGO PACHECO DE FREITAS FRAGA,
LEILA DO NASCIMENTO VIEIRA, CLARISSA ALVES CAPRESTANO, DOUGLAS ANDRÉ
STEINMACHER, GUSTAVO AMADEU MICKE, ROSETE PESCADOR, MIGUEL PEDRO
GUERRA
U - 19
ENDOGENOUS FREE POLYAMINES LEVELS OF ANANAS COMOSUS
VAR. COMOSUS NODULE CLUSTER CULTURES USING TEMPORARY IMMERSION
BIOREACTORS HUGO PACHECO DE FREITAS FRAGA, RAMON FELIPE SCHERER,
ANTONIO CORRÊA GARCIA, LÍRIO LUIZ DAL VESCO, DOUGLAS ANDRÉ
STEINMACHER, MIGUEL PEDRO GUERRA
U - 20
HISTOCHEMICAL ANALYSIS OF CALLUSES OF CEDRELA FISSILIS
VELOSO (MELIACEAE) FERNANDA KOKOWICZ PILATTI, EDER CARLOS SCHMIDT,
ZENILDA LAURITA BOUZON, ANA MARIA VIANA
U - 21
HISTOMORPHOLOGY DURING
SOMATIC EMBRYOGENESIS
INDUCTION OF ACCA SELLOWIANA (O. BERG). BURRET IN RESPONSE TO THE DNA
120
METHYLATION INHIBITOR 5-AZACITIDINE LEILA DO NASCIMENTO VIEIRA, HUGO
PACHECO DE FREITAS FRAGA, ROSETE PESCADOR, MIGUEL PEDRO GUERRA
U - 22
EFFECTS OF DNA METHYLATION INHIBITOR 5-AZACITIDINE ON THE
CONVERSION OF ACCA SELLOWIANA SOMATIC EMBRYOS (O. BERG). BURRET
LEILA DO NASCIMENTO VIEIRA, HUGO PACHECO DE FREITAS FRAGA, CLARISSA
ALVES CAPRESTANO, ROSETE PESCADOR, MIGUEL PEDRO GUERRA
U - 23
EFFECTS OF ULTRAVIOLET RADIATION-B IN THE RED ALGAE
LAURENCIA CATARINENSIS (CERAMIALES, RHODOPHYTA DÉBORA TOMAZI
PEREIRA, ÉDER CARLOS SCHMIDT, LUCIANE CRISTINA OURIQUES
U - 24
COMPARATIVE ANALYSIS OF THE CELL ORGANIZATION OF
PORPHYRA ACANTHOPHORA VAR. BRASILIENSIS UNDER THE EFFECTS OF
ENVIRONMENTAL RADIATION, PAR, AND ARTIFICIAL ULTRAVIOLET RADIATION-B
ZENILDA LAURITA BOUNZON, CARMEN S. ZITTA, RODRIGO W. DOS SANTOS,
LUCIANE C. OURIQUES, CAROLINE DE FAVERI, CLAUDIANE GOUVEIA, EDER C.
SCHMIDT
U - 25
TISSUE-SPECIFIC EXPRESSION PATTERN ANALYSES OF OSASR5
(ABA, STRESS AND RIPENING) PROMOTER IN RICE (ORYZA SATIVA L.) MARIANA
SCHUNEMANN, RAFAEL AUGUSTO ARENHART, ADRIANO SILVÉRIO, JORGE
ERNESTO DE ARAUJO MARIATH, MÁRCIA MARIA AUXILIADORA NASCHENVENG
PINHEIRO MARGIS
U - 26
INCREASED SUPEROXIDE DISMUTASE ACTIVITY IN SOYBEAN
TREATED WITH MANGANESE-DESFERRIOXAMINE B JÉSSICA BORDOTTI NOBRE
ESPOSITO, BRENO PANNIA ESPOSITO, RICARDO ANTUNES AZEVEDO, SILVIA
RIBEIRO DE SOUZA
U - 27
EFFECTS OF COPPER ON THE ARCHITECTURE AND
ULTRASTRUCTURE OF THE RED ALGAE GRACILARIA DOMINGENSIS
(GRACILARIALES, RHODOPHYTA) MARIANNE G. KREUSCH, CLAUDIANE GOUVEIA,
ÉDER C. SCHMIDT, RODRIGO W. DOS SANTOS, ZENILDA L. BOUZON
U - 28
CYTOCHEMICAL AND ULTRASTRUCTURAL CHANGES INDUCED BY
UVB RADIATION ON SEEDLING TETRASPOROPHYTIC OF PALISADA FLAGELIFERA
(CERAMIALES, RHODOPHYTA). LUCIANE CRISTINA OURIQUES, DÉBORA TOMAZI
PEREIRA, ÉDER CARLOS SCHMIDT
U - 29
IMMUNOMODULATORY ACTIVITY OF AQUEOUS EXTRACT
OBTAINED FROM THE STEM BARK OF BOWDICHIA VIRGILIOIDES KUNTH IN MICE
LARISSA FERNANDA DE ARAUJO VIEIRA, MARIA DANIELMA DOS SANTOS REIS,
ALTAIR ROGÉRIO ALVES BRANDÃO, THEREZINHA DE JESUS CALADO, EMILIANO
BARRETO, SALETE SMANIOTTO
U - 30
A PP2C PROTEIN IN RESPONSE TO COLD TEMPERATURE OF
ARAUCARIA ANGUSTIFOLIA ROBERTA ALVARES CAMPOS, LEONARDO JO,
FERNANDA PICCOLO PIERUZZI, JÉSSICA FERNANDES PEREIRA, IGOR LUCOVES
SICCHI, NATALIA PISCIRILLO, SÂMILA BIANCHE LOPES, CAROLINE ARCANJO BUENO,
AMANDA F MACEDO, ANDRÉ LUIS WENDT DOS SANTOS, ENY IOCHEVET SEGAL
FLOH
U - 31
ANATOMICAL CHANGES INDUCED BY ARSENIC IN WATER
HYACINTH (EICHHORNIA CRASSIPES (MART.) SOLMS) IULLA NAIFF RABELO DE
SOUZA REIS, JURACI ALVES DE OLIVEIRA, MARÍLIA CONTIN VENTRELLA, JOSÉ
CAMBRAIA, REGIANE APARECIDA CANATTO
U - 32
PROTEOMIC ANALYSIS OF TWO VARIETIES OF ZEA MAYS
INOCULATED WITH AZOSPIRILLUM BRASILENSE FP2 ALEXANDRO CÉZAR FALEIRO,
ELIANDRO ESPINDULA, TOMAS PELLIZZARO PEREIRA, ANA CAROLINA
MAISONNAVE ARISI
U - 33
MORPHO-HYSTOLOGICAL FEATURES IN IN VITRO PROTOCORMLIKE BODIES OF CATTLEYA TIGRINA RAFAELA DUARTE DE LIZ, MARISA SANTOS,
YOHAN FRITSCHE, ROSETE PESCADOR, MIGUEL PEDRO GUERRA
MARIA LUIZA TOMAZI PEREIRA, BRUNA SCHEID, NEUSA STEINER, GLADYS DANIELA
ROGGE RENNER, ÉDER CARLOS SCHMIDT, ZENILDA BOUZON, MIGUEL PEDRO
GUERRA
U - 40
MORPHOLOGICAL CHARACTERIZATION BY SCANNING ELECTRON
MICROSCOPY OF SOMATIC PRO-EMBRYOS OF ARAUCARIA ANGUSTIFOLIA
FRANCINE LUNARDI FARIAS SOARES, MARIA LUIZA TOMAZI PEREIRA, BRUNA
SCHEID, NEUSA STEINER, GLADYS DANIELA ROGGE RENNER, ÉDER CARLOS
SCHMIDT, ZENILDA BOUZON, MIGUEL PEDRO GUERRA
U - 41
ROLE OF NITRIC OXIDE MOLECULE IN TOLERANCE TO ARSENIC IN
PISTIA STRATIOTES: SIGNAL OR ANTIOXIDANT? FERNANDA DOS SANTOS
FARNESE, JURACI ALVES DE OLIVEIRA, LUHAN ISAAC SIMAN, REGIANE APARECIDA
CANATTO, CRISTIANE JOVELINA DA SILVA
V – Plasma Membrane
and Organelles
V1-V10
V-1
AQUAPORIN LOCALIZATION IN ANT EXCRETORY SYSTEM MARIA
DO CARMO QUEIROZ FIALHO, DIHEGO DE OLIVEIRA AZEVEDO, LUIZA CARLA
BARBOSA MARTINS, JOSÉ EDUARDO SERRÃO
V-2
WATER-FLUXES AND THE FUNCTION OF CANALICULI IN THE
MIDGUT OF PHIBALOSOMA PHYLLINUM (PHASMIDA, PHASMATIDAE) EMILIANO
CARNEIRO MONTEIRO, WALTER RIBEIRO TERRA, ALBERTO AUGUSTO GONÇALVES
DE FREITAS CASTRO RIBEIRO
V-3
THE DIGESTIVE SYSTEM OF BUCEPHALOGONIA XANTHOPHIS
(HEMIPTERA, CICADELLIDAE): THE ORGANIZATION OF THE LUMINAL SYSTEM OF
MEMBRANES ALEXANDRE HIROSHI UTIYAMA, WALTER RIBEIRO TERRA, ALBERTO
FREITAS RIBEIRO
V-4
INFLUENCE OF ALKALINE PH ON MAGNETOSOME FORMATION BY
“CANDIDATUS MAGNETOVIBRIO BLAKEMOREI” PEDRO ERNESTO LOPES LEÃO,
FERNANDA ABREU, DENNIS A. BAZYLINSKI, ULYSSES LINS
V-5
PATHWAYS REGULATING SECRETORY LYSOSOME BIOGENESIS AND
SECRETION ABBIE L NEILSON, ERICA B WILSON, JOSEPHINE L MEADE, JACQUELYN
BOND, GRAHAM P COOK
V-6
EXPOSURE OF LUMINAL MEMBRANES OF LLC-PK1 CELLS TO ANG II
INDUCES DIMERIZATION OF AT1/AT2 RECEPTORS TO ACTIVATE SERCA AND TO
PROMOTE CA2+ MOBILIZATION FERNANDA MAGALHÃES FERRÃO, LUCIENNE
SILVA LARA, FLÁVIA AXELBAND, JULIANA DIAS, ADRIANA K CARMONA, ROSANA I
REIS, CLÁUDIO M COSTA-NETO, ADALBERTO VIEYRA, JENNIFER LOWE
V-7
STRUCTURAL CHARACTERIZATION OF CARGO-BINDING SITES OF
THE MU4-SUBUNIT OF ADAPTOR PROTEIN COMPLEX 4 BREYAN H. ROSS, YIMO
LIN, PATRICIA V. BURGOS, JUAN S. BONIFACINO, GONZALO A. MARDONES
V-8
ORGANIZATION OF THE DIGESTIVE SYSTEM OF THE FRUIT FLY
ANASTREPHA SERPENTINA (DIPTERA: TEPHRITIDAE) CAMILA SILVA LEAL,
ALEXANDRE HIROSHI UTIYAMA, ALBERTO FREITAS RIBEIRO
V-9
RAPID ASSEMBLY AND INTERNALIZATION OF CAVEOLAE PROMOTE
RESEALING IN INJURED CELLS AND MUSCLE FIBERS PATRICIA ELAINE DE ALMEIDA,
MATTHIAS CORROTTE, CHRISTINA TAM, MARIA CECILIA FERNANDES, MAURO
CORTEZ, TIMOTHY K. MAUGEL, NORMA W. ANDREWS
U - 34
NITRIC OXIDE ATTENUATE THE OXIDATIVE STRESS AS-INDUCED IN
LETTUCE LEAVES NEIDIQUELE MARIA SILVEIRA, JURACI ALVES DE OLIVEIRA, LUHAN
ISAAC SIMAN, FERNANDA SANTOS FARNESE, CLÉBERSON RIBEIRO, REGIANE
APARECIDA CANATTO
V - 10
THE LISOSOMAL TARGETING OF CD4 BY HIV-1 NEF REQUIRES Γ2, A
NOVEL ISOFORM OF GAMMA ADAPTIN EULÁLIA MARIA LIMA DA SILVA, RODRIGO
ORLANDINI DE CASTRO, LUIS LAMBERTI PINTO DA SILVA
U - 35
EFFECTS OF DIFFERENT CYTOKININS ON CELL PROLIFERATION OF
ROLLINIA MUCOSA (JACQ.) BAILL. FOR SECONDARY METABOLITES PRODUCTION
THIAGO JOSÉ DE SOUZA BARBOZA, CECÍLIA DE AZEVEDO SOUZA, DÉBORA DE
AGUIAR LAGE, NORMA ALBARELLO
X – Proteolysis
U - 36
CYTOTOXICITY STUDY OF NORANTEA BRASILIENSIS METHANOL
EXTRACTS USING BRINE SHRIMP LETHALITY TEST ANNA FLÁVIA RODRIGUES
MORTANI VILARDO, GRAZIELA DA SILVA MELLO, ANALU FONSECA DE SÁ, NORMA
ALBARELLO
U - 37
EFFECTS OF ULTRAVIOLET-B RADIATION IN CELL ORGANIZATION
DURING THE INITIAL DEVELOPMENT OF NEMALION HELMINHOIDES (VELLEY IN
WITH.) BATTERS (NEMALIALES, RHODOPHYTA) ELIANA DE MEDEIROS OLIVEIRA,
LUCIANE CRISTINA OURIQUES
U - 38
ROLE OF THE GOLGI APPARATUS IN STORAGE OF SECONDARY
METABOLITES IN RED ALGA LAURENCIA DENDROIDEA. LILIAN JORGE HILL,
LEONARDO TAVARES SALGADO
U - 39
HYSTOCHEMICAL CHARACTERIZATION OF SOMATIC PROEMBRYOS OF ARAUCARIA ANGUSTIFOLIA FRANCINE LUNARDI FARIAS SOARES,
X1-X10
X-1
AGH IS A NEW HEMOGLOBIN ALPHA-CHAIN FRAGMENT WITH
ANTINOCICEPTIVE BIOLOGICAL ACTIVITY NATALIA MAZINI RIBEIRO, LILIAN C.
RUSSO, LEANDRO M. CASTRO, CAMILA S. DALE, ALANA R. FIGUEIREDO, FABIO C.
GOZZO, VANESSA RIOLI, EMER S. FERRO
X -2
PURIFICATION AND PARTIAL BIOCHEMICAL CHARACTERIZATION
OF A METALLOPROTEASE FROM BOTHROPS MOOJENI VENOM THALITA
KRISTHINA ALVES SILVA, CARLA CRISTINE NEVES MAMEDE, MAYARA RIBEIRO DE
QUEIROZ, BRUNA BARBOSA DE SOUSA, ANA LUIZA ZACOUR MARINHO, NADIA
CRISTINA GOMES DE MORAIS, KELLY CORTES FONSECA, DÉBORAH FERNANDA DA
CUNHA PEREIRA, THAÍS MIRANDA MIGLIORINI, MARIANA SANTOS MATIAS, FÁBIO
DE OLIVEIRA
121
X -3
INTRACELLULAR PEPTIDE ANALYSES IN CELLS EXPRESSING THE
IMMUNE PROTEASOME: POSSIBLE CORRELATIONS TO CELL SIGNALING
ELISABETE RODRIGUES DO MONTE SILVA, EMER SUAVINHO FERRO, VANESSA
RIOLI, LILIAN C RUSSO, LEANDRO M. DE CASTRO, FÁBIO C. GOZZO
X -4
IDENTIFICATION OF E3 UBIQUITIN- LIGASE SCF1(FBXO25)
SUBSTRATES THROUGH THE UBIQUITINATION IN VITRO ASSAY USING PROTEIN
MICROARRAY FELIPE ROBERTI TEIXEIRA, ADRIANA OLIVEIRA MANFIOLLI, CLÁUDIA
SOSSAI SOARES, ANA CAROLIAN HUMANES, MARCELO DAMARIO GOMES
X -5
FUNCTIONAL CHARACTERIZATION OF THE FBXO25 NUCLEAR
BODIES (FANDS) ADRIANA OLIVEIRA MANFIOLLI, FELIPE ROBERTI TEIXEIRA,
MUNIRA MUHAMMAD ABDEL BAQUI, CLÁUDIA SOSSAI SOARES, ANA CAROLINA
HUMANES, CACILDA DIAS PEREIRA, MARCELO DAMÁRIO GOMES
X -6
PURIFICATION AND CHARACTERIZATION BIOCHEMISTRY OF P3G2:
AN ENZYME COAGULANT AND Α- FIBRINOGENOLYTIC SNAKE VENOM OF
BOTHROPS MOOJENI MARIANA SANTOS MATIAS, ANA LUIZA ZACOUR MARINHO,
MAYARA RIBEIRO DE QUEIROZ, CARLA CRISTINE NEVES MAMEDE, DÉBORAH
FERNANDA DA CUNHA PEREIRA, THALITA KRISTHINA ALVES SILVA, KELLY CORTES
FONSECA, THAÍS MIRANDA MIGLIORINI, BRUNA BARBOSA DE SOUSA, NADIA
CRISTINA GOMES DE MORAIS, IGOR DE AZAMBUJA QUEIROZ RIBEIRO, FÁBIO DE
OLIVEIRA
X -7
CLONING AND EXPRESSION OF A RECOMBINANT SERINE
PROTEASE INHIBITOR FROM LOXOSCELES INTERMEDIA VENOM: A MEMBER OF
SERPIN FAMILY LUIZA HELENA GREMSKI, JENIFER NOWATZKI, DILZA TREVISAN
SILVA, RAFAEL BERTONI DA SILVEIRA, WALDEMIRO GREMSKI, ANDREA SENFF
RIBEIRO, OLGA MEIRI CHAIM, SILVIO SANCHES VEIGA
X -8
ANALYSIS OF SUBSTRATES AND PRODUCTS OF NEUROLYSIN (EC
3.4.24.16) IN MOUSE BRAIN USING QUANTITATIVE PEPTIDOMICS LEANDRO
MANTOVANI DE CASTRO, VITOR OLIVEIRA, FÁBIO CÉZAR GOZZO, EMER SUAVINHO
FERRO
X -9
EVALUATION
OF
BIOLOGICAL
ACTIVITY
OF
MATRIX
METALLOPROTEINASES FROM THE VENOM OF BOTHROPS ATROX AFTER
AUTOPROTEOLYSIS REBECCA TAVARES E SILVA, MARIA DAS DORES NOGUEIRA
NORONHA, ANDRÉ MIASATO HIGA, ANDRÉ LUIZ FERREIRA DA SILVA, KARLA
NUNES DA SILVA, PAULA CRISTINA BRÍGIDO CARVALHO NEVES, JORGE LUIS LÓPEZLOZANO
X -10
EDEMATOGENIC ACTIVITY INDUCED BY TOXINS FROM THE
BOTHROPS ATROX VENOM AFTER AUTOPROTEOLYSIS REBECCA TAVARES E SILVA,
MARIA DAS DORES NOGUEIRA NORONHA, ANDRÉ MIASATO HIGA, ANDRÉ LUIZ
FERREIRA DA SILVA, KARLA NUNES DA SILVA, PAULA CRISTINA BRÍGIDO CARVALHO
NEVES, JORGE LUIS LÓPEZ-LOZANO
Z – Stem Cells
Z1-Z42
Z-1
EFFECTS OF THE PLATELET–ACTIVATING FACTOR ON THE
PLURIPOTENCY OF MURINE EMBRYONIC STEM CELLS PAULA VIEGAS PEREIRA
SIGNORETTI, LUCIANNE FRAGEL MADEIRA
Z-2
ULTRASTRUCTURE OF THE REGENERATIVE CELLS OF THE MIDGUT
OF CERAEOCHRYSA CLAVERI (NAVÁS, 1911) (NEUROPTERA: CHRYSOPIDAE)
ELTON LUIZ SCUDELER, DANIELA CARVALHO DOS SANTOS, MONIQUE CAMPOS
PEREIRA, ANA SILVIA GIMENES GARCIA, PATRÍCIA FERNANDA FELIPE PINHEIRO
Z-3
ISOLATION AND CHARACTERIZATION OF STEM/PROGENITOR
CELLS PROPERTIES OBTAINED OF HUMAN BREAST CANCER CELL LINE MILENE
PEREIRA MOREIRA, GEOVANNI DANTAS CASSALI, LUCIANA MARIA SILVA
Z-4
LEPTIN FRAGMENTS MODULATE THE MURINE HEMATOPIESIS
CAROLINA CARVALHO DIAS, AMANDA NOGUEIRA-PEDRO, CHRISTIANO M. VAZ
BARBOSA, VANI XAVIER DE OLIVEIRA JUNIOR, ANTONIO MIRANDA, EDGAR J.
PAREDES-GAMERO
Z-5
GLUTATHIONE DEPENDENT OSTEOGENIC DIFFERENTIATION OF
SKIN MESENCHYMAL PROGENITORS OCCURS THROUGH MAPK SIGNALING
MARIA FERNANDA FORNI, LAURA POLIZEL, ADRIANO SARTORI, ERIK HALCSIK,
ETELVINO BECHARA, MARI CLEIDE SOGAYAR
Z-6
VIABILITY, PROLIFERATION AND GENOTOXIC EFFECTS OF
ELECTROSPRAYING ON MESENCHYMAL STEM CELLS DAIKELLY IGLESIAS
BRAGHIROLLI, FERNANDA ZAMBONNI, PEDRO CHAGASTELLES, DINARA MOURA,
JENIFER SAFFI, JOÃO ANTÔNIO PEGAS HENRIQUES, DIOGO ANDRÉ PILGER,
PATRICIA PRANKE
Z-7
TISSUE REGENERATION, BIOENGINEERING AND STEM CELLS:
BIBLIOMETRIC ANALYSIS OF PUBLICATIONS BETWEEN 2000 AND 2010 CRISTIANE
REGINA SCHER, PEDRO CHAGASTELLES, ALEXANDRE MENEGHELLO FUENTEFRIA,
PATRICIA PRANKE
Z-8
ISOLATION
AND
NEUROGENIC
DIFFERENTIATION
OF
MESENCHYMAL STEM CELLS FROM HUMAN DECIDUOS TEETH PULP VIRGINIA
ETGES HELFER, THAYANE CRESTANI, KERLIN QUINTILIANO, DIOGO ANDRÉ PILGER,
PATRÍCIA PRANKE
Z-9
INFLUENCE OF THE TIME OF INCUBATION ON MESENCHYMAL
STEM CELL ADHESION ON NANOFIBER MATRICES DAVI SILVEIRA DOS SANTOSS,
KERLIN QUINTILIANO, THAYANE CRESTANI, VIRGINIA ETGES HELFER, DAIKELLY
IGLESIAS BRAGHIROLLI, DIOGO ANDRÉ PILGER, PATRICIA PRANKE
Z - 10
INCORPORATION OF VEGF ON PLGA SCAFFOLDS PRODUCED BY
ELECTROSPINNING ANNELISE RIBEIRO DA ROSA, KERLIN QUINTILIANO, DANIELA
STEFFENS, NÍVEO STEFFEN, DIOGO ANDRÉ PILGER, PATRICIA PRANKE
Z - 11
DEVELOPMENT OF NGF LOADED SCAFFOLDS AND ASSOCIATION
WITH MESENCHYMAL STEM CELLS FOR NERVE TISSUE ENGINEERING KERLIN
QUINTILIANO, THAYANE ANTONIOLLI CRESTANI, DAVI SILVEIRA DOS SANTOS,
VIRGINIA ETGES HELFER, ANNELISE RIBEIRO DA ROSA, GERALDO PEREIRA JOTZ,
DIOGO ANDRÉ PILGER, PATRICIA PRANKE
Z - 12
A NEW BIOMATERIAL OF NANOFIBERS WITH THE MICROALGA
SPIRULINA AS SCAFFOLDS FOR USE IN TISSUE ENGINEERING DANIELA STEFFENS,
MICHELLE LERSCH, ANNELISE ROSA, CRISTIANE SCHER, THAYANE CRESTANI,
MICHELE GREQUE MORAIS, JORGE ALBERTO VIEIRA DA COSTA, PATRICIA PRANKE
Z - 13
EVALUATION OF BONE REGENERATION PROMOTED BY THE
ASSOCIATION OF SCAFFOLDS SEEDED WITH STEM CELLS FROM THE PULP OF
HUMAN DECIDUOUS TEETH GERSON ARISOLY XAVIER ACASIGUA, LISIANE
BERNARDI, DAIKELLY IGLESIAS BRAGHIROLLI, MANOEL SANT”ANA FILHO, PATRICIA
PRANKE, ANNA CHRISTINA MEDEIROS FOSSATI
Z - 14
MESENCHYMAL STEM CELL ADHESION AND PROLIFERATION RATES
ON SCAFFOLDS OF POLY(LACTIC-CO-GLYCOLIC ACID) (PLGA) WITH DIFFERENT
NANOFIBER DIAMETERS FERNANDA ZAMBONI, MARIANA DE CONTO FIN,
DAIKELLY IGLESIAS BRAGHIROLLI, DIOGO ANDRÉ PILGER, PATRICIA PRANKE
Z - 15
CHARACTERIZATION OF CULTURE EXPANDED MULTIPOTENT
MESENCHYMAL STROMAL CELLS FROM EQUINE ADIPOSE TISSUE ARMANDO DE
MATTOS CARVALHO, ANA LUCIA MILUZZI YAMADA, MARJORIE ASSIS GOLIM, LUIS
EMILIANO C ÁLVAREZ, LUCIANA LEAL JORGE, MARIANA LOPES, ELENICE DEFFUNE,
CARLOS ALBERTO HUSSNI, ANA LIZ GARCIA ALVES
Z - 16
ISOLATION OF MESENCHYMAL STEM CELLS FROM THE CARDIAC
MUSCLE OF GALLUS GALLUS RAQUEL CALLONI, PATRICK TURCK, GABRIHEL
STUMPF VIEGAS, ELVIRA ALÍCIA APARÍCIO CORDERO, DIEGO BONATTO
Z - 17
THE ROLE OF CASRS DURING ADULT RAT MESENCHYMAL STEM
CELLS PROLIFERATION AND APOPTOSIS FERNANDA MARIA POLICARPO TONELLI,
RODRIGO RIBEIRO RESENDE, LUIZ ORLANDO LADEIRA
Z - 18
BIOMODULATION OF HUMAN EMBRYONIC STEM CELLS AFTER
LOW POWER LASER IRRADIATION JULIANA F. MANGOLIN, ANDREZA C. DE
SIQUEIRA SILVA, ERIANE ELLER DE SIQUEIRA, SUEMI SOARES BATISTA, CRISTINA
PACHECO SOARES, NEWTON SOARES DA SILVA
Z - 19
MESENCHYMAL STEM CELLS THERAPY IN ANIMAL MODEL OF
DILATED CARDIOMYOPATHY INDUCED BY DOXORUBICIN: TROPONIN I LEVELS
AND HISTOLOGICAL EVALUATION. HELENA FLORES MELLO, PRISCILLA
DOMINGUES MÖRSCHBÄCHER, TUANE NERISSA ALVES GARCEZ, ANA HELENA DA
ROSA PAZ, ALESSANDRA BILESKI MAGRISSO, VIVIAM NUNES PIGNONE, LANUCHA
FIDELIS DA LUZ MOURA, ANELISE BONILLA TRINDADE, ELIZABETH OBINO CIRNELIMA, EMERSON ANTÔNIO CONTESINI
Z - 20
EVALUATION OF FREQUENCY AND FUNCTIONALITY OF
MESENCHYMAL CELL POPULATIONS IN OBESE AND EX-OBESE HUMAN
SUBCUTANEOUS ADIPOSE TISSUE KARINA RIBEIRO DA SILVA, JOAO REGIS IVAR
CARNEIRO, CESAR CLAUDIO-DA-SILVA, ANTÔNIO AUGUSTO PEIXOTO DE SOUZA,
RADOVAN BOROJEVIC, LEANDRA SANTOS BAPTISTA
Z - 21
HUMAN MENSTRUAL BLOOD DERIVED MESENCHYMAL CELLS AS
NEW HUMAN FEEDER-LAYER SYSTEM FOR HUMAN EMBRYONIC STEM CELLS
DANÚBIA SILVA DOS SANTOS, VANESSA CARVALHO COELHO DE OLIVEIRA, KARINA
DUTRA ASENSI, LEANDRO VAIRO, ADRIANA BASTOS CARVALHO, ANTONIO CARLOS
CAMPOS DE CARVALHO, REGINA COELI DOS SANTOS GOLDENBERG
Z - 22
MAGNETIC RESONANCE IMAGING DETECTS EMBRYONIC STEM
CELLS LABELED WITH SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES IN
THE MURINE HEART GUILHERME VISCONDE BRASIL, DANÚBIA SILVA DOS SANTOS,
ANDRÉIA DE VASCONCELOS DOS SANTOS, CLERIO FRANCISCO DE AZEVEDO FILHO,
FERNANDA FREIRE TOVAR MOLL, ROSÁLIA MENDEZ OTERO, REGINA COELI DOS
SANTOS GOLDENBERG, ANTONIO CARLOS CAMPOS DE CARVALHO
Z - 23
DEVELOPMENT OF A NEW METHODOLOGY OF HUMAN DERMIS
STEM CELL ENCAPSULATION IN CARRAGEENAN HYDROGEL ADDELI BEZ BATTI
ANGULSKI, MICHELE RODE, TALITA JEREMIAS, LEILA HAYASHI, ANDREA
GONÇALVES TRENTIN, GIORDANO WOSGRAU CALLONI
Z - 24
17-BETA-ESTRADIOL EFFECTS IN MESENCHYMAL STEM CELLS
UNDER OSTEOGENIC DIFFERENTIATION IN VITRO. PATRICK TURCK, RAQUEL
CALLONI, GABRIHEL STUMPF VIEGAS, ELVIRA ALÍCIA APARÍCIO CORDERO, DIEGO
BONATTO
Z - 25
EFFECTS OF DEXAMETHASONE ON MESENCHYMAL STEM CELLS
MORPHOLOGY, FUNCTIONALITY AND VIABILITY NATÁLIA SCHNEIDER, FABIANY
DA COSTA GONÇALVES, HELENA FLORES MELLO, CRISTINA FLORES, ELIZABETH
122
OBINO CIRNE LIMA, EDUARDO PANDOLFI PASSOS, LUÍSE MEURER, ANA HELENA
DA ROSA PAZ
Z - 26
MESENCHYMAL STEM CELLS FROM MENSTRUAL BLOOD ARE
MORE RESISTANT TO OXIDATIVE STRESS THAN PLURIPOTENT STEM CELLS
KARINA DUTRA ASENSI, RODRIGO SOARES FORTUNATO, DANIELLE FERREIRA DE
REZENDE, THAÍSA SILVA PACHECO, DANÚBIA SILVA DOS SANTOS, DEIVID DE
CARVALHO RODRIGUES, TAIS HANAE KASAI-BRUNSWICK, ELAINE CRISTINA LIMA
DE SOUZA, ANTONIO CARLOS CAMPOS DE CARVALHO, DENISE PIRES CARVALHO,
ADRIANA BASTOS CARVALHO, REGINA COELI DOS SANTOS GOLDENBERG
Z - 41
THREE-DIMENSIONAL SUGARCANE-BASED SCAFFOLD FOR HUMAN
MESENCHYMAL STEM CELLS CULTURE MARYANA ROBERTA PEDROSA DIAS,
BELYSSA SANTOS DE MORAES, ANDRIU DOS SANTOS CATENA, LUANA
ALBUQUERQUE BARROS, SILVÂNIA TAVARES PAZ, ELIETE CAVALCANTI DA SILVA,
JOSÉ LAMARTINE DE ANDRADE AGUIAR, PALOMA LYS DE MEDEIROS
Z - 42
A FLORAL REPRESSOR BROTHER OF FT AND TFL1 (BFT)
MODULATES FLOWERING INITIATION UNDER HIGH SALINITY IN ARABIDOPSIS JE
CHANG WOO, JAE YONG RYU, PIL JOON SEO, CHUNG-MO PARK
Z - 27
COMPARISON BETWEEN FIBROBLASTS AND MESENCHYMAL STEM
CELLS DERIVED FROM DERMAL AND ADIPOSE TISSUE CARLA ABDO BROHEM,
CAROLINE LEAL RADOSKI, CAMILA MIRANDA DE CARVALHO, MARCELA CONTADOR
BAPTISTA, BRUNA BASTOS SWINKA, FLÁVIA CRYSTINA SANTI, CÍCERO DE ANDRADE
URBAN, RUTH MARIA GRAF, ISRAEL HENRIQUE STOKFISZ FEFERMAN, MÁRCIO
LORENCINI
Z - 28
IN VITRO AND IN VIVO OSTEOINDUCTIVE POTENTIAL OF POLY-3HYDROXYBUTYRATE/POLYBUTYLENE SUCCINATE SCAFFOLDS COLONIZED BY
ADIPOSE TISSUE DERIVED STEM CELLS THAIS MARIA DA MATA MARTINS, ANA
CLÁUDIA CHAGAS DE PAULA, ALESSANDRA ZONARI, ALEXANDRA RODRIGUES
PEREIRA DA SILVA, SILVIENE NOVIKOFF, ALFREDO MIRANDA DE GOES
Z - 29
CHARACTERIZATION OF MULTIPOTENT MESENCHYMAL STROMAL
CELLS OBTAINED FROM WHOLE BONE MARROW PLATED WITHOUT FICOLL
GRADIENT NAYARA DE FREITAS MARTINS, FERNANDA BARRA FRANCO, FERNANDA
DE SOUZA MARTINS, PATRÍCIA FIDELIS DE OLIVEIRA
Z - 30
HAIR FOLLICLE DERIVED MESENCHYMAL CELLS SUPPORT
UNDIFFERENTIATED GROWTH OF HUMAN EMBRYONIC STEM CELLS VANESSA
CARVALHO COELHO DE OLIVEIRA, DANÚBIA SILVA DOS SANTOS, LEANDRO VAIRO,
ADRIANA BASTOS CARVALHO, ANTÔNIO CARLOS CAMPOS DE CARVALHO, REGINA
COELI DOS SANTOS GOLDENBERG
Z - 31
CELL THERAPY AND PHYSICAL ACTIVITY: A THERAPEUTIC
APPROACH IN A MICE SPINAL CORD INJURY TAMIRES BRAGA MASSOTO, MARINA
BAIRROS HEBERLE, FERNANDA MARTINS DE ALMEIDA, ADRIANO BIANCALANA,
ANA MARIA BLANCO MARTINEZ, SUELEN ADRIANI MARQUES
Z - 32
EFFECTS OF AGING ON THE SUBVENTRICULAR ZONE OF THE
MURINE BRAIN ARE REGULATED BY GROWTH HORMONE TREATMENT IN VIVO
AND IN VITRO. MARILIA KIMIE SHIMABUKURO, LARISSA GUTMAN PARANHOS
LANGHI, CHIN JIA LIN, ROGER CHAMMAS, CLAUDIA MARIA DE CASTRO BATISTA,
VALÉRIA DE MELLO-COELHO
Z - 33
EXTRACELLULAR ADENINE NUCLEOTIDES METABOLISM IN
MESENCHYMAL STEM CELLS FROM DIFFERENT MURINE TISSUES ISABELE
CRISTIANA ISER, PAULA ANDREGHETTO BRACCO, RAFAEL FERNANDES ZANIN,
NANCE BEYER NARDI, ANA MARIA OLIVEIRA BATTASTINI, MÁRCIA ROSÂNGELA
WINK
Z - 34
ROLE OF CARDIAC MICROENVIRONMENT ON CARDIOMYOGENIC
DIFFERENTIATION OF STEM CELLS ANNY WALOSKI ROBERT, ANA PAULA RESSETTI
ABUD, ANDRESSA VAZ SCHITTINI, ALEJANDRO CORREA, MARISE B. A. COSTA,
FRANCISCO D. A. COSTA, ALEXANDRA SENEGAGLIA, PAULO S. BROFMAN, MARCO
AUGUSTO STIMAMIGLIO
Z - 35
FUNCIONAL AND PHENOTYPICAL CHARACTERIZATION OF ACUTE
CHAGASIC CARDIOMYOPATHY IN CHIMERIC MICE CAMILA IANSEN IRION, BRUNO
DIAS PAREDES, GUILHERME VISCONDE BRASIL, SANDRO TORRENTES DA CUNHA,
DÉBORA BASTOS MELLO, ISALIRA PEROBA REZENDE RAMOS, ANTONIO CARLOS
CAMPOS DE CARVALHO, ADRIANA BASTOS CARVALHO, REGINA COELI DOS
SANTOS GOLDENBERG
Z - 36
ALTERED OXYGEN METABOLISM ASSOCIATED TO NEUROGENESIS
OF INDUCED PLURIPOTENT STEM CELLS DERIVED FROM A SCHIZOPHRENIC
PATIENT BRUNA DA SILVEIRA PAULSEN, RENATA DE MORAES MACIEL, ANTONIO
GALINA, MARIANA SOUZA SILVEIRA, CLEIDE DOS SANTOS SOUZA, HANNAH
DRUMMOND, ERNESTO NASCIMENTO POZZATTO, HAMILTON SILVA JUNIOR,
LEONARDO CHICAYBAM, RAFFAEL MASSUDA, PEDRO SETTI PERDIGÃO, MARTIN
BONAMINO, PAULO SILVA BELMONTE DE ABREU, NEWTON GOLÇALVES CASTRO,
HELENA BRENTANI, STEVENS KASTRUP REHEN
Z - 37
NEW APPROACH TO CULTURE HUMAN ADIPOSE STEM CELL
SEEDED ON PHB-HV SCAFFOLDS FOR BONE TISSUE ENGINEERING APPLICATION
ANA CLAUDIA CHAGAS DE PAULA, ALEXANDRA RODRIGUES PEREIRA DA SILVA,
ALESSANDRA ZONARI, THAÍS MARIA DA MATA MARTINS, SILVIENE NOVIKOFF,
ALFREDO MIRANDA GOES
Z - 38
CHARACTERIZATION OF ISOLATED AND CULTURE EXPANDED
SYNOVIAL MESENCHYMAL STEM CELLS FROM HORSES SYNOVIUM. ANA LIZ
GARCIA ALVES, JAYESH DUDHIA, ROBERTA FERRO DE GODOY, ROGER K W SMITH
Z - 39
EPIDERMAL GROWTH FACTOR-SCAFFOLDS AND MESENCHYMAL
STEM CELLS: A NEW APPROACH FOR NERVE TISSUE ENGINEERING THAYANE
CRESTANI, KERLIN QUINTILIANO, VIRGINIA ETGES HELFER, DAVI SILVEIRA DOS
SANTOS, GERALDO JOTZ, DIOGO ANDRÉ PILGER, PATRICIA PRANKE
Z - 40
ANALYSIS OF THE UNFOLDED PROTEIN RESPONSE (UPR) IN
EMBRYONIC STEM CELLS DAIANNE NEVES MANDARINO TORRES, MARIANA
PARANHOS STELLING, STEVENS KASTRUP REHEN, LUCIANA BARRETO CHIARINI
123
Author Index
ABDELHAY ESFW
ABRAHAO TB
ABRANCHES MV
ABREU GA
ABREU IS
ABREU JG
ABREU LA
ABREU RMM
ABRUNHOSA VM
ACASIGUA GAX
ADACHI P
AFONSO RCH
AGOSTINHO LA
AGOSTINI LP
AGUIAR DP
AGUIAR JMC
AGUIAR JUNIOR O
AGUIAR RB
AGUIAR TT
AIRES MB
ALBARELLO N
ALBUQUERQUE AV
ALEVI KCC
ALLODI A
ALLODI S
ALMEIDA ACF
ALMEIDA CEV
ALMEIDA CJG
ALMEIDA GS
ALMEIDA JC
ALMEIDA MES
ALMEIDA MF
ALMEIDA NK
ALMEIDA PE
ALMEIDA RSC
ALMEIDA SL
ALMEIDA TF
ALMEIDA VR
ALONSO GC
ALPONTI RF
ALVES ALG
ALVES GG
ALVES HHO
ALVES LL
ALVES LP
ALVES MGCF
ALVES NR
ALVES RMS
AMARAL MGC
AMARAL RF
AMARAL SS
AMBRÓSIO F
AMMAR D
AMORIM R
ANDRADE HM
ANDRADE IR
ANDRADE JKF
ANDRADE LM
ANDRADE LO
ANGULSKI ABB
ANHÊ ACB
ANSELMO TC
ANTONIOLI E
APOLINARIO LM
AQUINO T
ARAGAO AB
ARAGÃO BC
ARAN V
ARAÚJO AF
ARAUJO CB
ARAÚJO DAM
ARAUJO EG
ARAÚJO EP
ARAÚJO FA
ARAUJO H
ARAÚJO HMM
ARAÚJO HSS
ARAUJO JUNIOR ALC
ARAÚJO JÚNIOR RF
ARAUJO KCL
ARAÚJO LCC
ARAÚJO MDD
ARAÚJO RMS
ARAÚJO TG
ARAÚJO WM
ARAÚJO-MARTINS L
ARCEGO DM
ARCHANGELO LF
B - 117
J - 37
B -48
U-9
H - 16
B – 221, J – 46,
N – 42, N - 43
J - 28
S-3
A - 81
Z - 13
P - 32
B - 194
T - 10
B - 93
N - 33
N - 51
D - 94
B - 250
A - 83
D – 40, D - 42
U – 35, U - 36
D - 11
D – 18, D – 113,
D – 117, D –
118, D – 124
T-4
F – 3, I - 1
R -43
B-3
C - 108
C - 14
N - 32
I-9
T - 35
R -69
V-9
J - 34
U-7
C-5
K - 10
H - 19
A - 119
Z – 15, Z - 38
E -6, E -9, S –
22, T - 49
A - 84
C - 70
I-7
A-8
D - 115
L-1
A - 76
B - 97
G-5
C – 76, C – 78
N - 34
R -48
J - 31
M -1
B - 180
B-1
R -9, R -11
Z - 23
S-9
C - 43
A-4
C - 55
E -4
J - 40
T - 25
J - 12
C - 92
G - 12
B – 60, B – 206,
B – 208,
F – 10, T – 45, T
-50, T - 64
C – 115, J - 48
C – 68, C - 110
J - 45
N – 19, N - 48
B – 98, B – 99, B
- 157
B -207
B – 94, B - 111
R -32
C - 111
B - 195
O -4
B -209, M -9
B - 76
T - 64
T - 65
A - 26
ARISI ACM
ARMELIN HA
ARMILIATO N
ARO AA
ARRUDA LB
ARRUDA RF
ASENSI KD
ASSIS LHC
ASSUNÇÃO CLS
ASSUNÇÃO FS
ATHAYDE RM
ATTIAS M
ATTIAS M
AUGUSTO LMM
AUGUSTO LS
AUGUSTO TM
AVELAR GF
AVILA RA
AYRES R
AYUB LC
AZEREDO-OLIVEIRA MTV
AZEVEDO CS
AZEVEDO EPC
AZEVEDO OGR
BACK SH
BAHIA D
BALARINI MK
BANZATO TP
BÁO SN
BAPTISTA LS
BAPTISTA MS
BARBOSA AS
BARBOSA CRR
BARBOSA FAR
BARBOSA GO
BARBOSA JLP
BARBOSA LA
BARBOZA TJS
BARCELOS LS
BARJA-FIDALGO C
BARRETO EO
BARROS CM
BARROS LG
BARROS LRC
BARROS NMT
BARROS SBM
BARROS TAA
BARROS ZAV
BASTIANI MA
BASTOS IMF
BASTOS NF
BATISTA AA
BATISTA JR M
BATISTA JÚNIOR ML
BATISTA NV
BATISTA TH
BATTATASTINI AMO
BECKENKAMP A
BEGNINI KR
BEGUELINI MR
BEHLING CS
BELETTI ME
BELIZÁRIO J
BELLINI MH
BELTRAN JSO
BELUSSO JV
BENCHIMOL M
BENFATO MS
BENJAMIM CF
BERALDI EJ
BERBERT LR
BERNARDES PTT
BERNARDO PS
BERNHARD T
BERNI MA
BERTAGLIA RS
BERTOZZI E
BETTEGA M
BEVILACQUA E
BIANCALANA A
BIANCARDI MF
U - 32
B – 82, B – 112,
F – 1, J - 25
D - 61
P - 15
G - 18
B - 158
Z - 26
D - 68
B - 189
B - 106
C - 23
R -27, R -29, R 35
S - 24
H - 17
A - 102
B - 137
D - 140
R -75
F - 15
B - 186
D – 16, D – 18, D
– 19, D – 20, D –
21, D – 22, D 86
S - 28
C - 75
C – 49, R -17
C - 22
J – 34, R -36
D - 31
D - 50
B – 12, B – 15, B
- 22
S – 15, Z - 20
G – 21, S - 18
K - 15
B-7
A - 16
P - 35
C - 41
B - 44
U - 35
K - 15
B – 171, C – 112,
C - 117
C - 92
A – 12, A – 74, A
– 78, H – 16, T 27
C - 21
C - 83
B - 235
G - 30
I-3
Q -3
C - 16
R -67, S - 28
B - 239
A – 64, B - 226
C - 67
F - 26
C - 35
F - 20
B - 181
B – 108, B - 153
B - 225
D - 90
D - 57
D – 92, D – 121,
D – 122, D –
123, D – 125, D
– 126, R -32
B - 184
Q -3
G - 17
C – 84, C - 87
G – 6, M -1, R -3,
R -4, R -7, R - 8
C – 31
C – 69, C – 70, C
– 85, I - 8
T - 43
I - 13
C – 24, C - 25
B - 236
E -4
N - 48
A - 31
R -7
G - 37
D – 63, D – 120,
D - 139
S - 30
D - 133
BIASOLI D
BIGUETTI CC
BINDA NETO I
BIRUKOV K
BIRUKOVA A
BISPO-DA-SILVA LB
BITTENCOURT JÚNIOR PIH
BIZARRO HDAS
BLASIOS JUNIOR V
BLOISE FFB
BOMFIM AMD
BOMFIM CCB
BOMFIM RS
BONATTO D
BONDAN EF
BONFIM DC
BORBA HR
BORDIN DL
BORELLA MI
BORELLI P
BORGES AC
BORGES BN
BORGES HL
BORGES LF
BOTTAS LS
BOURCKHARDT GF
BOUZON ZL
BOZZA FA
BOZZA P
BOZZA PT
BRACCO PA
BRACHER F
BRAGA CA
BRAGA LC
BRAGA LEG
BRAGHIROLLI DI
BRANCO PC
BRANDT JZ
BRASIL GV
BRENO MC
BRIE I-C
BRINGEL RAR
BRITO IRR
BRITO MV
BRITO NETO JM
BRITO NM
BRITO TLA
BROHEM CA
BRUNO AN
BRUSCO J
BUBIK A
BUENO GCL
BUFFOLO MA
BUFFON A
BURGOS PV
BUSATTO FF
BUSTAMANTE H
BUTTOW NC
BUZATO CBC
CABRAL FILHO PE
CAETANO FH
CAGNON VHA
CAIXEIRO APA
CAIXETA DC
CALAZA KC
CALDEIRA EJ
CALDINI EG
CALLONI GW
CALLONI R
CÂMARA AR
CAMARGO KC
CAMARGOS DS
CAMPOS D
CAMPOS JUNIOR PHA
CAMPOS LM
CAMPOS MRC
CAMPOS MS
CAMPOS RA
CAMPOS SGP
CAMPOS SPC
CAMPOS TA
CAMPOS VMA
CANATTO RA
CANDIDO NM
CANIUGUIR A
B - 52
C-8
J - 36
J-2
J-1
A - 33
C - 27
C - 107
M -10
H-4
T - 28
B - 60
A - 85
Z – 16, Z - 24
T – 53, T - 54
J - 30
B – 2, R -1
B - 156
A - 98
G - 17
Q -5
B – 195, B – 200,
O -16, O -17
B – 52, B – 143,
C - 93
P – 27, P - 29
T - 29
N - 34
U – 7, U – 13, U
– 14, U – 16, U –
17, U – 24, U 27
G - 38
R -68
C – 95, C – 97, C
– 107, C – 108, R
-61, R -62
B - 244
R -60
D - 114
O -3
T - 47
Z-6
I – 5, S - 26
D - 17
Z - 22
J - 10
B - 58
T - 48
B - 227
R -73
N – 1, N - 50
B - 171
P - 12
Z - 27
B - 147
T - 70
T-85
B - 65
N - 26
B – 87, B – 95, B
– 108, B – 153, B
- 170
T - 52
B - 152
T - 52
T - 43
J - 11
S - 19
G – 3, L - 1
D – 91, D – 96, D
– 98, D – 105, D
- 129
A - 18
A - 65
T - 60
C-1
P - 11
A – 16, Z - 23
Z - 16
N - 45
N - 37
B - 42
T - 12
D - 72
N - 40
A - 49
D - 137
U - 30
D - 51
R -64
A - 66
B – 3, B - 14
U – 31, U - 34
B - 36
A - 46
124
CANO MIN
CANUTO KS
CAPITANIO JS
CAPPELLARI AR
CAPUCHO C
CARA DC
CARBALLO CB
CARDEAL LBS
CARDIN LT
CARDOSO C
CARDOSO LHD
CARDOSO MG
CARDOSO SV
CARDOSO VM
CARMO ER
CARMO LAS
CARNEIRO K
CARREIRA ACO
CARVALHO ACC
CARVALHO ADZ
CARVALHO AF
CARVALHO AL
CARVALHO ALH
CARVALHO AM
CARVALHO CR
CARVALHO DFF
CARVALHO HF
CARVALHO JG
CARVALHO LA
CARVALHO MGC
CARVALHO ND
CARVALHO RVH
CARVALHO SC
CASALI VVC
CASANELLO P
CASTELUCCI BG
CASTRO LM
CASTRO NFC
CASTRUCCI AML
CATAE AF
CATISTI R
CATROXO MHB
CAVALCANTE LA
CAVALCANTI DP
CAVALHEIRO GRC
CAVALHEIRO RP
CECON E
CELLA N
CERRI PS
CHAIM OM
CHAMMAS R
CHAVES CR
CHAVES NL
CHAVES RS
CHEDID RA
CHEN Y-H
CHIARINI LB
CHIELA ECF
CHIN-YUAN H
CHUANG Y-L
CHUNG HT
CICCONE CC
CIPRIANO I
CISTERNA AEC
CLOUTHIER DE
COELHO VM
COGO AJD
COLANERI GN
COLLARES T
COLLARES-BUZATO CB
COLQUHOUN A
CONTESINI EA
COOK GP
CORDEIRO E
CORDEIRO IR
CORDEIRO RC
CORDEIRO RS
CORREA A
CORREA CL
CORRÊA DEC
CORRÊA JR
CORREA OMT
CORRÊA-FEITOSA VL
CORRÊA-JUNIOR JD
CORREA-NORONHA SAA
CORTE ALVA
CÔRTE-REAL S
CORTEZ BA
COSSOLIN JFS
COSTA AFAF
COSTA AGB
A – 3, A – 35, F –
18, F - 21
B - 20
B – 71, B - 212
B - 181
D - 14
C – 19, C – 34, C
– 35, C - 39
A – 85, C - 91
B - 61
C - 30
B - 249
J - 22
O -11
B - 11
N - 30
B - 252
A - 89
N - 13
K - 14
Z - 22
C - 57
T - 56
B - 217
B - 150
Z - 15
C – 40, C – 43, C
- 44
T - 75
A – 36, A – 105,
B – 137, B – 138,
E -11, H – 12, I –
6, P - 35
B-6
T - 19
B - 154
G - 36
R -53
C - 60
L-2
A - 46
D – 15, D - 131
X -8
D - 107
A – 120, J - 41
S-1
D-1
S-7
T - 19
S - 14
N - 35
B - 86
C - 105
J – 15, J - 27
G - 32
S - 25
B - 166
F-4
B -15
T - 42
N - 47
B-5
B – 237, F – 19,
Z - 40
S-2
G – 1, G - 2
G-1
C - 22
P–2
N - 10
P-4
N-2
C - 77
H - 18
B - 78
B - 213
F-8
B – 177, B - 178
Z - 19
V-5
C - 17
N-4
T - 56
N - 21
O -13
I-1
H - 10
B - 172
D - 13
A – 21, A - 22
A – 107, F – 6, R
-10, S - 5
B - 77
F - 11
A – 97, A - 100
B - 130
G-8
B - 211
C - 66
COSTA ALC
COSTA BRC
COSTA CFP
COSTA CGCM
COSTA EBO
COSTA FLP
COSTA GA
COSTA GMJ
COSTA JP
COSTA LJ
COSTA MFD
COSTA ML
COSTA MSA
COSTA NCS
COSTA RA
COSTA RMB
COSTA SM
COUTO BHCV
CRECZYNSKI-PASA TB
CREMA VO
CRESTANI T
CRUZ CKF
CRUZ CU
CRUZ MVT
CRUZ TA
CUNHA MS
CURY GCG
CUSTÓDIO MR
DALMAZ C
DAL-PAI-SILVA M
DALPIAN F
DAMASCENO EM
DAMATTA RA
DAMIANI RM
DANTAS VWM
DAVID LRS
DEALMEIDA CE
DELELLA FK
DEZONNE RS
DIAMANTE MAS
DIAS BRS
DIAS CC
DIAS FCR
DIAS G
DIAS GS
DIAS MA
DIAS MHS
DIAS MRP
DIAS MVS
DIAS OFG
DIAS RB
DIAS RS
DIAS SMG
DIAS WB
DIAZ BL
DÍAZ JAM
DINIZ CWP
DINIZ JR JAP
DINIZ LP
DOBRANSKY T
DOLDER H
DOLDER MAH
DOMENICONI RF
DONADIO JL
DONATTI L
DORE CMPG
DÓRIA JG
DREWES CC
DUARTE MEL
DUARTE ML
DUBOC LF
DUMAS ML
DUPIN E
DURANTE AC
DURVALE MC
EL-CHEIKH MC
ELLWANGER JH
EMRICH LC
ESPINDOLA FS
ESPOSITO JBN
ESPREAFICO EM
ESQUISATTO MAM
ESTRELA MS
EVANGELISTA RC
I-2
D - 24
B - 182
H-6
T - 14
B - 131
D - 74
A - 114
R -44, R -48, R 50, R -58
R -13
H – 5, N - 40
A - 112
B - 129
C - 40
B - 201
B – 183, S - 20
R -9
A – 72, B - 189
H – 7, T - 58
Z - 39
D - 116
A – 38, K - 11
T - 38
R -29
R -58
R -47
A - 96 D – 107, D
– 108, D – 113,
D – 117, D –
118, D - 124D –
127, D - 130
T – 30, T - 65
A – 31, A - 37
T-8
A – 56, A - 57
A – 83, C – 99, E
-7, E -8, R -49, R
-57
B - 204
B - 146
B - 12
B – 14, B - 17
D-3
T - 72
A – 91, B - 197
R -71
Z-4
D - 54
D – 43, D – 64
K-8
B - 132
B - 112
Z - 41
T - 51
B - 25
H - 14
C - 29
B - 57
B - 45
B - 215
B - 68
T – 11, T - 31
R -73
T - 59
T – 23, T - 32
D – 95, G - 31
A – 60, A – 91, B
– 197, D – 28, D
– 29, D - 30
D - 67
B - 45
A – 67, A - 92
B - 67
T - 67
B - 165
H - 17
A - 25
A - 56
B - 55
N - 51
B - 98
M -6
F-9
T - 12
A - 74
A – 58, A – 62, A
- 65
U - 26
B – 228, B – 241,
B -243, B – 247,
B – 248, B – 249,
Q -5
P – 1, P – 2, P –
6, P – 8, P – 9, P
– 13
B - 240
C - 51
FAÇANHA ALO
FAÇANHA AR
FACCIOLI CK
FACCIOLI LAP
FACINA CH
FADEL AC
FAGANELLO J
FALCAO VTFL
FALEIRO AC
FARIA AMC
FARIA JAQA
FARIA NETO HCC
FARIA PA
FARIA PR
FARIA TF
FARIAS ND
FARIAS PS
FARNESE FS
FARO TAS
FARSKY SHP
FAVARO PMB
FÉ AR
FEIO DCA
FEITOZA F
FELBER YT
FELICIONI F
FELIPPE DC
FELISBINO SL
FELIX RL
FÊO HB
FERNANDES DC
FERNANDES KPS
FERNANDES LR
FERNANDES PCC
FERRÃO FM
FERRÃO PM
FERRARI MFR
FERREIRA AF
FERREIRA AMR
FERREIRA AT
FERREIRA AVM
FERREIRA FF
FERREIRA FRL
FERREIRA GJ
FERREIRA KBO
FERREIRA LC
FERREIRA LRL
FERREIRA PCG
FERREIRA WAS
FERREIRA-MACHADO SC
FERRER VP
FERRO ES
FIALHO MCQ
FIERRO IM
FIGLIUOLO VR
FIGUEIRA SF
FIGUEIREDO CC
FIGUEIREDO DTA
FIGUEIREDO JB
FIGUEIREDO MS
FILIPPIN FB
FIORE APZP
FISCHER-FODOR E
FLÁVIO KAPCZINSKI F
FLOH EIS
FLORIM JC
FOCHI RA
FOCK RA
FOGAÇA E
FOGUEL D
FONSECA AS
FONSECA BF
FONSECA CG
FONSECA FL
FONSECA HLS
FONSECA MC
FONSECA RC
FONSECA WF
FONTANETTI CS
FONTES A
FONTES AM
FORNI MF
FORTES GB
FORTI FL
FOSSATI ACM
FRADE PCR
FRAGA HPF
FRANÇA FS
FRANÇA LR
H - 18
B – 63, B – 131,
B - 158
N – 44, N - 49
K-1
D – 53, D – 86
T - 26
R -54
J - 11
U - 32
C - 118
O -12
C - 74
G - 16
B – 18, B - 107
C - 42
B - 62
D - 42
J – 32, J – 42, U 42
B - 200
B - 165
B - 122
C - 86
B - 238
B - 178
D - 81
D – 87, D – 101
N - 31
B – 26, B – 216,
D-3
U - 17
P - 13
J – 16, S - 21
C – 21, C – 58, C
- 62
B - 185
R -33
V-6
P - 26
A – 29, T – 13, T
– 29, T – 35, T –
42
R -43
B – 163, B - 164
H - 15
R -26
N - 39
B -127
T-4
C - 96
P - 14
T - 37
O -18, U - 37
O -16
B -17
P-5
G – 12, X -1, X -8
V-1
C - 86
J - 47
B - 219
B -127
R -67
C - 85
J - 43
B - 214
F - 14
B - 58
G - 34
U - 30
I - 10
D - 100
C - 11
D - 78
C – 66, C - 75
B -16, B – 20, B –
31, F - 5
J - 46
B – 88,T – 18, T
– 2, T - 25
R -28
H - 11
T-3
C - 39
D - 106
A - 64
S – 16, S - 19
H-6
Z–5
B - 162
M -4, M -5
Z - 13
A - 111
U – 18, U - 19
B - 29
D – 36, D – 68, D
– 70, D – 72, D –
73, D – 74,
D
125
FRANÇA MM
FRANCELIN C
FRANCISCO G
FRANCISCO JS
FRANCO DG
FRANCO FO
FRANCO RM
FRANCO-BELUSSI L
FRANK S
FRANKE SIR
FREIRE NETO CA
FREITAS C
FREITAS EHS
FREITAS JR
FREITAS KM
FREITAS LJA
FREITAS MAR
FREITAS SM
FREITAS VM
FRIESLAND A
FROTA PB
FRUET AC
FUNCHAL C
FUNGARO TP
FURLAN AS
FURTADO IMA
FURTADO RR
GALHARDO MS
GALINDO LT
GALLÃO MI
GAMA P
GAMEIRO J
GANDOLPHI LC
GARCIA ASG
GARCIA E COSTA F
GARCIA HC
GARCIA MCD
GARCIA PMA
GARDESANI WKM
GARNIQUE ADMB
GARZONI LR
GASTARDELO TS
GATTASS CR
GAUTHIER-ROUVIÈRE C
GEISSLER K
GELALETI GB
GENTI-RAIMONDI S
GERALDO AHPS
GHIZONI H
GIANNOTTI KC
GICQUEL T
GIL CD
GIORDANO RJ
GIROL AP
GITIRANA LB
GOBBO MG
GODA M
GODOY BB
GOES AM
GÓES RM
GOLDENBER RCS
GOMES A
GOMES AL
GOMES FCA
GOMES FILHO SA
GOMES FS
GOMES GF
GOMES JMM
GOMES JR
GOMES L
GOMES LF
GOMES MD
GOMES MPSM
GOMES PF
GOMEZ MV
GOMEZ RS
GONÇALVES BF
GONÇALVES CA
GONÇALVES GJM
GONÇALVES IB
GONÇALVES RC
GONÇALVES WA
GONTIJO JAR
GONZAGA ACR
GONZÁLEZ A
GONZÁLEZ MJ
– 80, D – 82, D –
140
B - 104
A-5
B - 166
A - 108
C - 100
F - 26
U-1
C-2
N - 24
A – 17, A – 32, T
- 40
B - 72
R -68
O -10
B – 151, C - 10
A – 60, G - 31
D – 44, D - 46
R -74
B - 75
B – 73, B – 115,
B – 168, B - 199
M -2
T - 46
G - 30
L-4
C - 32
A - 45
N - 16
R -72
P - 11
I-4
U – 1, U – 10, U
– 2, U – 5, U - 9
A – 1, F – 14, F –
17, H – 1, J - 39
R -53
D - 108
D - 77
D - 93
D - 11
H-8
D - 82
S - 18
B -192
A – 39, P - 26
B - 41
B – 37, B - 38
J-6
C - 36
B - 103
A - 55
P - 32
A-1
C - 59
A - 79
C - 72
B – 61, B - 80
C-3
A – 108, K - 6
A - 63
M -13
J-8
Z – 28, Z - 37
A – 63, D – 24, D
– 41, D – 69
K – 1, K – 8, P –
34, Z – 21, Z –
26, Z – 30, Z - 35
T - 75
N – 28, N - 35
T – 34, T – 59, T
– 63, T – 72, T 84
C - 110
C - 115
T - 11
F-6
B – 151, B – 186,
B – 252, C - 10,
N - 37
P-7
D - 66
X -4, X - 5
T - 18
A - 15
T – 14, T - 68
T-1
D - 23
C - 73
B - 107
A - 26
J - 16
C - 79
N - 14
D - 32
B - 109
A - 117
GORJÃO R
GÓRNIAK SL
GORTZ LW
GOSMANN G
GOTTFRIED C
GOULART FILHO LR
GOULART LR
GOUVEIA C
GOZZO EC
GRANATO AEC
GRANJA MG
GRANJEIRO JM
GREGORIO LS
GREMSKI LH
GRUND LZ
GUATIMOSIM C
GUEDES CES
GUEDES HG
GUEIROS FILHO FJ
GUERRA CR
GUERRA MP
GUERRA MT
GUERRANT RL
GUIDO BC
GUILHERME RF
GUILLAUME E
GUIMARÃES IM
GUIMARÃES LPTPG
GUSMAN GS
HA KS
HACKENHAAR FS
HADDAD NF
HAEMMERLE CAS
HAGA RB
HAGE AAP
HAIFIG I
HAJJ G
HAMAO K
HAN SW
HANSEN HP
HATANAKA E
HAUSEN MA
HAYASHI JPM
HAYASHI MAF
HEBLING A
HELFER VE
HELUANY CS
HENRIQUE BVM
HENRIQUES F
HENRIQUES JAP
HENRIQUES MG
HENRIQUES MGMO
HERINGER AS
HERLINGER AL
HERNANDES L
HETZL AC
HILL LJ
HIRAIWA SH
HIRAKI KRN
HIRATA CL
HOFMANN JUNIOR AE
HOLLMANN G
HOSCH NG
HOSOYA H
HOTTZ ED
HROMAS R
HUMMEL LAB
IAMONTE M
IERARDI DF
IGLESIA RP
IKEDA ET
INTROÍNI GO
IONTA M
IONTA M
IRION CI
ISER IC
JACKSON K
JACOB CRO
JAEGER MC
JAEGER RG
JAMUR MC
JASIULIONIS MG
JASIULIONIS MG
JESUS LWO
JIMÉNEZ-GARCÍA LF
JOANITTI GA
A - 84
S - 23
G - 35
B -160
T - 44
B – 174, M -9
B -209
U - 16
X -3
A - 59
T - 45
G – 11, G – 15, S
- 15
D-4
X -7
J-9
T – 3, T - 38
R -63
B - 94
M -6, M -10
R -30
U – 11, U – 12, U
– 15, U – 18, U –
19, U – 21, U –
22, U – 33, U –
40, U - 41
D - 55
R -17
B - 172
C - 69
J-6
T - 32
B - 38
J - 42
B - 53
C - 31
B -66
T - 62
J - 20
A - 116
A - 19
T - 36
A - 73
K – 3, Q -1, Q -4
B - 119
A – 44, C - 47
K-7
C - 58
B – 224, B - 251
P-7
Z-8
J-7
B - 242
C - 67
B – 156, B – 173,
C – 4, F - 11
C - 109
R -52
U – 11, U - 12
B – 85, B - 232
R -22, R -23
D - 91
U - 39
D - 104
B - 175
J - 27
A – 68, D - 103
F-3
F - 22
A – 73, A – 75,
M -7
G - 38
B - 56
T - 49
A - 48
B - 49
T - 74
T - 71
D - 52
F - 20
F – 22, F – 27, H
- 10
Z - 35
Z - 33
S - 13
L-7
B - 196
B – 74, B – 125,
B – 167, B - 220
A – 28, A – 49, R
-25
B – 30, B – 49, B
- 78
J – 19, O -8, O 9, O -15
A - 98
A - 118
B - 75
JOAZEIRO PP
JONATHAN GS
JORGE EC
JUSTO GZ
KAJISHIMA AL
KALDIS P
KANG KR
KANNO TYN
KATO KC
KATZ SG
KAWAHARA R
KAWALL HG
KEDE J
KEMPINAS WG
KERKIS I
KIDO LA
KIM S-M
KIOKA N
KIPPER FC
KISAKI MK
KLAMT F
KOBARG J
KOBUS K
KONDO T
KOS L
KRAUSE LMF
KREBSBACH P
KREUSCH MG
KRUEGER B
KUHNE F
LABRIOLA L
LACERDA JZ
LACERDA SMSN
LACERDA TCS
LACOUTH P
LADEIRA LO
LADISLAU T
LAGENTE V
LAH TT
LAMERS ML
LAMIM T
LAMPERT C
LANCELLOTTI M
LANDIM BC
LANGHI LGP
LARA NLM
LARANJO LT
LAUAND C
LAURA SIMON L
LAURINDO FRM
LAUS AC
LAZARI MFM
LAZARINI M
LAZAROTTI MP
LE DIAGON MMRQ
LE DOUARIN N
LEAL CS
LEAL L
LEÃO PEL
LEDUR PF
LEE CS
LEIGUEZ E
LEIMGRUBER C
LEITÃO A
LEITÃO RFC
LEITE EL
LEITE GB
LEITE JCA
LEITE MF
LEITE RP
LEME AFP
LEMOS MS
LENZ G
LEÓDIDO ACM
LEONARDO AMC
LEPLETIER A
LEYTON BJK
LIMA ABA
LIMA ACC
LIMA AM
LIMA C
LIMA EM
LIMA FRS
LIMA GB
LIMA GDA
LIMA LPO
LIMA MA
LIMA MS
LIMA NS
D – 12, D – 15, D
– 131, P - 17
R -40
N - 15
B – 148, B - 190
N - 42
F - 16
J - 13
N - 29
R -10
D - 88
B - 176
A - 13
J - 14
D – 49, D – 50, D
- 55
B – 251, K - 5
D - 98
A - 20
B - 96
A - 69
G - 27
B – 29, B – 149,
H – 13, T - 69
A – 45, J – 5, J –
8, J - 21
N - 46
A - 75
N - 36
B - 179
A - 67
U - 27
C - 36
A - 105
G-7
B - 83
D - 73
B - 222
A - 96
Z - 17
B - 198
A – 79, A - 80
Q -2
B – 25, B – 110,
E -10
N - 11
T - 66
R -20, R -42, R 46, R -47
M -8
C - 77
D - 70
A - 50
B - 113
K – 12, K - 13
A – 71, I – 7, J –
24, J – 37, S - 21
B - 217
D – 109, J - 29
J-4
B - 33
J - 10
N - 33
V-8
B - 245
V-4
B - 40
J - 13
C - 104
C-6
B - 56
B - 133
A – 8, B - 67
D-2
N-7
B – 1, F - 4
D – 28, D - 30
B – 176, J - 40
D - 92
B – 23, B – 40, B
– 89, B – 218, S 2
N - 17
A – 19, A - 50
I - 12
O -14
E -8
D - 21
I – 12, R -56
J-9
O -1 O -2 O -4
B – 88, B – 90, B
- 97
R -62
D - 34
R -24
B - 115
B - 173
A - 52
126
LIMA PDL
LIMA PHS
LIMA TC
LIMA TDFA
LIMA THA
LIMA VM
LIMA WS
LIMA-SALGADO TM
LINHARES ABR
LINO-NETO J
LINS MP
LINS U
LISBOA PC
LISONI FCR
LIZ RD
LOBATO S
LOBBA ARM
LOGULLO C
LOMBELLO CB
LONGHI MT
LOPES AA
LOPES AG
LOPES DV
LOPES FM
LOPES JR
LOPES KAR
LOPES MH
LOPES TS
LÓPEZ-LOZANO JL
LORENCINI M
LORENCINI RM
LORENZI VCB
LORENZON AR
LOTFI CFP
LOTUFO CMC
LOURENÇO ES
LOURO ID
LOWE J
LU Q
LU Z
LUCAS JZ
LUCENA SV
LUNA MS
MABUCHI I
MACCHI BM
MACEDO DS
MACHADO ACL
MACHADO CF
MACHADO CM
MACHADO DE
MACHADO JR J
MACHADO SM
MACHADO-SANTELLI GM
MADEIRA LF
MADEKUROZWA
MADI-RAVAZZI L
MAGRINI TD
MAI C
MAIA RC
MALASPINA O
MALDONADO CA
MALDONADO IRSC
MALPARTIDA HMG
MALTA JCO
MANCINI K
MANCINI KC
MANFIOLLI AO
MANGOLIN JF
MANHÃES AC
MANSANO ESB
MANSANO RAW
MARANGON CG
MARÇAL LN
MARCELINO RC
MARCIANO RS
MARCONDES PG
MARCUZZO S
MARDONES GA
MARGIS MMANP
MARIA-ENGLER SS
MARIA-ENGLER SS
MARIANO LIF
MARIN MT
MARKUS RP
MARQUES CAB
MARQUES IC
MARQUES MB
MARQUES MF
MARQUES MJ
MARQUES MR
MARQUES PE
B - 238
B - 191
B – 121, T - 57
F - 23
R -54
B – 2, R -1
R -19
C - 32
H-9
A – 18, D – 39, D
– 43, D – 64, D –
66
A - 30
V-4
A – 52, T – 73, T
- 79
C - 30
U - 33
B - 54
B - 70
A - 99
E -3
J - 15
C - 101
B - 132
C - 54
T - 69
B - 100
A-7
B – 43, T - 74
G - 15
X -10, X - 9
Z - 27
D - 129
A - 23
D - 120
B - 104
T - 57
S - 22
B – 92, B - 93
J – 22, V - 6
M -2
B-5
R -65
J - 33
B – 81, J - 3
M -13
C - 99
T - 55
A - 90
T - 33
D - 67
C - 61
B - 219
G - 10
A – 10, B – 113,
B – 130, N - 18
T – 9, Z - 1
M MC -3
A - 95
A-2
A - 17
B – 140, B - 236
L – 6, L – 7, S - 1
B – 21, C - 6
R -15, R -16
B - 245
A - 121
A - 51
A - 57
X -5
Z - 18
T - 83
R -22, R -23
G-7
B - 135
B – 51, S - 12
D - 106
B - 31
B - 50
T – 76, T – 77, T
- 78
V-7
U - 25
P – 30, J – 20, P
- 19
B - 214
D - 126
T - 61
C – 100, C – 105,
C - 113
N - 11
T - 55
B - 123
A - 94
A – 47, C – 55, C
- 60
T - 77
C - 15
MARQUES SA
MARQUES-SANTOS LF
MARQUES-SANTOS LFM
MARRIEL NB
MARTIN PKM
MARTINATTI CK
MARTINELLI PM
MARTINEZ AMB
MARTINEZ PAM
MARTINHO OCL
MARTINS AAB
MARTINS AB
MARTINS ACA
MARTINS AF
MARTINS AMC
MARTINS CM
MARTINS CS
MARTINS DFC
MARTINS FA
MARTINS FF
MARTINS GF
MARTINS GVF
MARTINS L
MARTINS MFM
MARTINS MR
MARTINS NF
MARTINS PR
MARTINS PR
MARTINS RAP
MARTINS TMM
MARTINS TVF
MARTINS VR
MARTINS VR
MARTINS WK
MASCHIO DA
MASSOTO TB
MATIAS ICP
MATIAS MS
MATOS AV
MATOS DG
MATOS NS
MATSUBARA FH
MATSUMOTO MA
MATSUMURA CY
MATTA SLP
MATTE U
MATTOS RM
MAYA-MONTEIRO CM
MAYORAL EE
MAZUCATOC VM
MAZZI DPSL
MEDEIROS J-VR
MEDEIROS PL
MEDINA BNSP
MEISSNER GO
MELISO FM
MELLO AA
MELLO CLO
MELLO CP
MELLO HF
MELLO JC
MELLO PA
MELLO-COELHO V
MELO AC
MELO CFV
MELO CM
MELO EN
MELO FP
MELO KCM
MELO RAM
MELO RCN
MELO RRS
MELO TQ
MENDES SP
MENDES-DA-CRUZ FS
MENDEZ-OTERO R
MENDONÇA FAS
MENDONÇA LM
MENDONÇA PP
MENDONÇA RZ
MENESES GCM
MENEZES GB
MENI AZ
MERLO S
MERMELSTEIN CS
Z - 31
D - 10
L - 3 N - 7 N - 12
N-8N-9
S-9
Q -4
G - 14
R -11
T - 22
N - 41
B – 9, B – 10, B 19
R -41
P - 34
A - 88
N - 15
G – 22, G - 26
A - 62
M -11
A - 12
A - 53
D-9
N - 17
B – 206, B - 208
P - 23
T - 53
C - 114
Z - 29
C-9
T-7
N – 20, N - 28
Z - 28
R -18
B – 43, B – 116,
B – 222
T – 33, T – 36, T
– 39, T – 41, T 51
G - 19
F-7
Z - 31
T - 34
X -6
C - 25
B - 143
B - 187
A - 103
C-8
A - 47
D – 25, D – 26, D
– 31, D – 85, D –
89, D – 134, D
- 135
A – 38, K – 11, K
– 12, K – 13
A-6
B – 239, C - 14
C-1
A - 24
B - 228
C – 37, C - 38
Z - 41
T - 27
A – 61, S - 25
O -8
A - 78
B - 237
G - 13
Z - 19
G - 24
B - 87
H – 4, H – 11, T –
82, Z - 32
C - 88
O -1, O -2
A - 34
D – 54, D – 119,
D – 132
C-7
R -34
B - 161
A – 89, C – 96, G
- 33 R -55
P - 33
A - 29
D - 65
B - 134
K – 16, T - 28
P - 10
R -50
D - 20
G - 36
G - 22
C – 15, C – 28, C
– 102, G - 5
S - 23
T – 15, T - 16
A – 81, H – 2, H
– 3, N - 26
MESQUITA LV
MESQUITA-FERRARI RA
METZ C
MIDLEJ VVP
MIETTO BS
MIMURA KK
MIRAGLIA SM
MIRANDA A
MIRANDA DC
MIRANDA F
MIRANDA MASP
MIRANDA NF
MIRANDA-ALVES L
MISSASSI G
MOLINA RAS
MOLOGNONI F
MOLZ P
MONESI N
MONTE SM
MONTE-ALTO COSTA A
MONTEIRO AC
MONTEIRO EC
MONTEIRO JC
MONTEIRO NS
MONTEIRO VA
MONTENEGRO RC
MONTICO F
MORAES AS
MORAES CA
MORAES GV
MORAES IB
MORAES JA
MORAES JZ
MORAES MNCM
MORAES VWR
MORAIS AS
MORAIS BP
MORAIS DB
MORANDI FILHO R
MORANDI V
MOREIRA CPS
MOREIRA JE
MOREIRA MP
MOREIRA RJP
MORGADO-DÍAZ JA
MORITA M
MOROZ A
MORRIS EAR
MORTARA RA
MOSCARDINI F
MOTOYAMA AB
MOTTA CM
MOTTA LL
MOTTA MCM
MOURA DJ
MOURA EG
MOURA GEDD
MOURA NETO V
MOURA RS
MOYSÉS GR
MÜLLER CB
MÜLLER YMR
MURATA GM
NADER HB
NAGAI MA
NAGAO PE
NAKAMA KK
NAKAYAMA ABS
NASCIMENTO AR
NASCIMENTO J
NASCIMENTO LF
NASCIMENTO LPS
NASCIMENTO NG
NASCIMENTO RD
NASCIMENTO SC
NASCIUTTI LE
NATALI MRM
NAVA A
NAVES TB
NAZARENO A
NAZARI EM
NDREWS NW
NEGRI E
NEILSON AL
NEIVA M
NETTO CA
NETTO FSF
E -5
C – 41, C - 56
B - 109
R -3
T - 22
C - 89
D – 6, D - 8
G-4
D – 85, D – 89, D
– 134, D - 135
B - 221
B - 133
B - 68
B -66
D - 49
B -243
B - 30
A – 32, T - 40
N - 16
C - 91
C – 5, C - 12
O -9
V-2
A - 51
O -5
B - 188
B - 234
D - 96
A – 54, N – 23, O
-7
T - 63
R -27
A - 58
C - 112
B – 250, C - 63
J - 41
G - 23
O -15
K-5
D – 25, D – 26, D
- 27
D – 123, D - 127
B - 146
B-7
T – 70, T – 71, T
– 15, T – 16, T 17
Z-3
B - 79
B – 50, B – 72, B
– 76, B – 79, B 191
M -7
B - 26
H-5
R -2, R -36
B - 105
B - 187
A - 90
H - 13
A – 88, F – 25, F
- 13
U-8
B -207, J - 43
J - 26
A – 106, B – 69,
B – 106, B - 194
B -24
B - 148
C - 16
D – 61, N – 30, N
– 39, N – 46
C - 47
B – 86, J - 26
B - 193
R -59
C - 103
T - 17
J - 29
B - 95
R -8
D - 94
C - 80
T – 5, T - 6
B - 223
A – 6, A – 77, B –
8, B – 105, C –
65, P - 18
T - 20
D - 138
T - 31
E -1
N - 38
V-9
C - 73
V-5
B - 224
G – 29, K - 4
J - 23
127
NEVES FMO
NEVES LMG
NEVES MM
NEVES RL
NICOLAU LAD
NIERO ELO
NISHAN U
NISIMURA LM
NITÃO ETGR
NOBRE LTDB
NOCE BPD
NOCITI JUNIOR FH
NOGUEIRA-MACHADO JA
NORMANN CABM
NOVAES RD
NUNES MCOF
NUNES PR
NUNES VS
NUÑEZ CEC
NUSSENZVEIG HM
OGIAS D
OKADA FK
OLALLA-SAAD S
OLIANI SM
OLIVA MLV
OLIVA SU
OLIVEIRA AC
OLIVEIRA ACBF
OLIVEIRA ADPR
OLIVEIRA APS
OLIVEIRA C
OLIVEIRA CA
OLIVEIRA CB
OLIVEIRA CFA
OLIVEIRA CJL
OLIVEIRA DC
OLIVEIRA EG
OLIVEIRA EM
OLIVEIRA F
OLIVEIRA FC
OLIVEIRA FP
OLIVEIRA JA
OLIVEIRA JC
OLIVEIRA JG
OLIVEIRA JS
OLIVEIRA JSS
OLIVEIRA LL
OLIVEIRA LP
OLIVEIRA ML
OLIVEIRA MP
OLIVEIRA PF
OLIVEIRA PT
OLIVEIRA RB
OLIVEIRA RJS
OLIVEIRA RL
OLIVEIRA RR
OLIVEIRA SBP
OLIVEIRA SKM
OLIVEIRA VA
OLIVEIRA VCC
OLIVER C
ORIÁ RB
ORNELAS IM
ORTOLANI-MACHADO CF
OSAKI JH
OSAKI LH
OSORIO LKP
OTA CCC
OURIQUES LC
PAÇÓ-LARSON ML
PADRÃO JC
PÁDUA TA
PAFFARO AMA
PAFFARO JUNIOR VA
PAIVA CAL
PAIVA PMG
PALLADINO MV
PALUDO KS
PANZETTA-DUTARI GM
PAOLI F
PAPA MP
PAREDES BD
PAREDES-GAMERO EJ
PARISE CB
PARK C-M
PARK H-S
N - 10
P - 10
D – 33, D - 34
B - 235
C – 37, C - 38
B -192
A - 42
A - 39
N – 9, N - 12
B - 139
A - 99
P - 23
J – 18, J - 23
L – 2, L - 4
R -15, R -16
N - 13
C – 27, F - 16
A-3
J - 48
S-8
F - 17
D-8
B – 122, B – 126,
J-4
B – 41, B – 83, C
– 3, C – 52, C –
71, C - 89
B – 91, B - 136
D-6
R -38, R -64
A - 106
S - 16
A - 22
C – 2, D – 2, D 4
D – 32, D – 47, D
– 48, D – 75, D –
76
B -160
D - 36
J - 28
C - 11
B-8
U - 38
X -2, X - 6
R -74
N - 43
J - 32
S-3
D – 104, M -8
D - 132
R -40
B -48, B – 129, S
- 12
P – 36, P - 37
E -11
B - 220
Z - 29
H – 19, M -11
F-8
B - 19
D - 76
C - 65
H - 12
C - 106
B - 149
Z - 30
A – 23, A - 24
C – 49, C – 50, C
– 51, T - 46
T - 80
D - 78
M -4
G – 14, J - 39
U - 13
G – 35, G - 37
U – 23, U – 28, U
- 38
A – 11, A – 14, A
– 15, A - 27
R -49
C - 64
D – 84, D – 87, D
– 101, D – 102,
D – 111, D - 114
D – 35, D – 56, D
– 62, D - 81
T - 10
C - 111
B - 190
R -45
A - 55
B -16
G - 18
A - 94
G – 4, Z - 4
C - 63
Z - 42
A - 20
PARREIRA GG
PASSOS JL
PASSOS LAC
PATRICIA PRANKE P
PAUL AL
PAULA ACC
PAULA CAA
PAULA JUNIOR R
PAULA SO
PAULSEN BS
PAZ AHR
PECLI E SILVA C
PEDREIRO MRD
PEDRO AN
PEDROSA CSG
PEIXOTO AR
PEIXOTO BC
PELAJO-MACHADO M
PENNACCHI PC
PENTEADO MV
PERDE-SCHREPLER M
PEREIRA BF
PEREIRA CG
PEREIRA CN
PEREIRA DA
PEREIRA DT
PEREIRA EMR
PEREIRA GB
PEREIRA JAL
PEREIRA JRCS
PEREIRA LA
PEREIRA LX
PEREIRA MC
PEREIRA MJB
PEREIRA MLG
PEREIRA NP
PEREIRA RFC
PEREIRA RVS
PEREIRA VS
PEREIRA-NEVES A
PERERIA NP
PEREZ AM
PEREZ APS
PEREZ DA
PEREZ MO
PERINI VR
PEROTTI TL
PERUQUETTI RL
PESSOA AFM
PETTENUZZO LF
PFAFFENSELLER B
PIAZZA FV
PIECHNIK CA
PIEDADE WP
PILATTI FK
PIMENTA MT
PIMENTEL ER
PINHAL MAS
PINHATTI AV
PINHEIRO APB
PINHEIRO CR
PINHEIRO NM
PINHEIRO PFF
PINHO CF
PINHO V
PINTO JS
PINTO ME
PINTO MT
PINTO NCS
PIRES BRB
PIRES DA
PIRES NPMD
PIZZATTI L
PIZZOL JÚNIOR JP
PLIEGO CM
POEYS SC
POITOU C
POLON L
POLTRONIERI AB
PONTES B
PONTES CLS
PORCIONATTO MA
PORTILHO NA
PÔRTO LCMS
PORTUGAL CC
POSER GV
POSSIDONIO ACB
POSSUELO L
POZZI R
PRADO JL
PRADO KM
PRADO LCS
PRADO PF
A - 43
D - 84
D - 105
Z – 6, Z – 7, Z –
8, Z – 10, Z – 9, Z
– 11, Z – 12, Z –
14, Z – 39
F - 12
Z - 37
B - 136
C - 72
C - 29
Z - 36
Z - 25
I-8
A - 92
B – 13, H - 15
G - 11
D - 99
O -18
N – 41, N - 22
P - 19
P-9
B - 59
G-3
B - 247
P - 22
B - 144
U - 23
T - 68
A - 11
A - 113
B - 34
T-9
A - 43
D-5
G-8
D - 93
D - 22
R -46
C - 34
L-5
R -4
D – 16, D - 19
F - 21
D - 128
C - 19
P - 16
D - 71
P-8
D - 83
C - 90
T - 30
G - 34
T – 76, T - 78
A - 13
A - 37
U - 20
D - 109
P – 15, P – 16, P
– 28, P – 36, P –
37
A – 34, P - 20
B - 64
D – 60, D - 79
T - 73
H-7
Z-2
D - 37
C – 13, C – 18, C
– 79, C – 81
B - 169
D - 69
J - 19
A - 87
B - 117
C - 28
N - 19
B - 65
G - 32
B - 163
R -44
C - 114
N - 50
C - 52
S-8
B - 157
A – 59, I – 3, I - 4
N - 22
C - 101
C - 78
B - 64
H-2
O -6
F-2
A - 93
D - 63
A - 33
R -70
PRADO PS
PRECUP C
PREDES FS
PRETA CMCC
PRIOR I
PROCÓPIO MS
PRUSCH DS
PRZEPIURA TCS
PUGA CCI
PULEGIO M
PUTTI JS
QUEIROZ AC
QUEIROZ FR
QUEIROZ MS
QUINTANA CYP
QUINTÃO JLD
QUINTAR AA
QUINTILIANO K
QUONDAMATTEO F
RABELO K
RABELO SM
RABINOVITCH M
RACHID CVM
RAHAL P
RAMÃO A
RAMOS AB
RAMOS BCR
RAMOS CA
RAMOS GOR
RAMOS MSC
RAMOS RGP
RAMOS TCP
RANGEL LBA
RAPOZO-YOUNES V
RASIA-FILHO A
RAULINO JCN
REAL FRO
REBELATO HJ
RECCO-PIMENTEL SM
REGO EM
REGO LNAA
REHEN SK
REIS AC
REIS CF
REIS DD
REIS DDA
REIS IDG
REIS INRS
REIS MC
REIS PA
REIS RM
RENNER GDR
RESENDE VTR
REZENDE BM
REZENDE KF
REZENDE-TEIXEIRA P
RIBAS VT
RIBEIRO AAGFC
RIBEIRO AF
RIBEIRO AHR
RIBEIRO DA
RIBEIRO DL
RIBEIRO FILHO AC
RIBEIRO FILHO J
RIBEIRO FM
RIBEIRO HJ
RIBEIRO JA
RIBEIRO JU
RIBEIRO LHG
RIBEIRO LM
RIBEIRO NM
RIBEIRO PC
RIBEIRO RR
RIBEIRO VMA
RICARDI LR
RIEDERER I
RIEGER A
RIETDORF JM
RINALDI JC
RIVAROLI L
RIVAROLI L
RIVERO ERC
RIZZO E
ROBBS BK
ROBERT AW
ROCHA CB
ROCHA GG
ROCHA HAO
ROCHA LO
ROCHA SC
ROCHAEL NC
RODARTE RS
RODRIGUES AA
RODRIGUES APD
D – 58, D - 59
B - 59
D - 95
F - 25
J - 12
A - 107
B - 155
G-9
D-7
D - 41
D - 57
B - 145
R -12
A - 27
P - 18
C - 102
B - 21
Z - 11
B - 119
S - 20
P - 29
R -21
B - 134
B – 35, B - 36
B - 248
K - 16
A - 120
A - 122
P - 25
C – 45, C – 46, C
– 103
A - 112
A - 101
B – 85, B – 198,
B – 232
T - 79
T-8
A – 121, A – 122
R -2
D-1
D - 52
B - 179
A - 95
Z - 36
C - 18
B - 102
T – 5, T – 6, T - 7
C-9
S - 17
U - 31
C - 42
C - 74
B – 9, B - 10
U - 15
K-2
C - 81
A - 115
N - 18
F - 19
V-2
V – 3, V - 8
N-1
B – 6, F - 2
D - 38
B - 13
C - 95
T - 67
S-5
A - 35
B - 226
D - 29
C - 116
X -1
G - 25
A - 36
R -19
A - 10
I – 11, P - 31
S - 27
S - 29
B - 216
R -65
R -75
P - 25
D – 44, D – 46, D
– 58, D – 59, D –
60, D – 71, D –
79, D - 116
G – 39
Z - 34
E -5
B - 37
B - 139
D - 125
B - 44
R -37
B – 205, B – 227
J – 38, R -31
A - 109
128
RODRIGUES BR
RODRIGUES C
RODRIGUES FV
RODRIGUES HA
RODRIGUES HF
RODRIGUES HF
RODRIGUES JCF
RODRIGUES LP
RODRIGUES MD
RODRIGUES ML
RODRIGUES PC
RODRIGUES PMGRS
RODRIGUES T
ROESLER R
ROMAN SS
ROMANA-SOUZA B
ROMÃO LF
RONDON AMR
ROQUE NR
ROSA AR
ROSA AS
ROSA HT
ROSA VS
ROSAS EC
ROSI MID
ROSS BH
ROSSI A
ROSSI MID
ROSSI PIVA MB
ROZENTAL S
RUANO RM
RUIZ AC
RUIZ RC
RUIZ TRG
RUMJANEK VMBD
SABA GT
SABATINO ME
SABINO PM
SADDI TM
SAEZ RC
SAFFI J
SAITO A
SALDANA-CABOVERDE A
SALES CF
SALGADO LT
SALLES ESL
SALLES GN
SAMPAIO MC
SANCHES BDA
SANCHES D
SANGIULIANO B
SANT’ANA FILHO M
SANT’ANNA C
SANTANA DB
SANTANA MAN
SANTANA PT
SANTOS AA
SANTOS AB
SANTOS ABG
SANTOS ACV
SANTOS AMF
SANTOS AO
SANTOS BS
SANTOS CA
SANTOS CLP
SANTOS DC
SANTOS DO
SANTOS DS
SANTOS E SILVA SV
SANTOS EM
SANTOS ESJ
SANTOS EV
SANTOS FCA
SANTOS HB
SANTOS HCP
SANTOS IGD
SANTOS JMCO
SANTOS JMP
SANTOS JN
SANTOS JR AR
SANTOS JS
SANTOS LL
SANTOS LM
SANTOS LPB
SANTOS MA
SANTOS MB
SANTOS MF
SANTOS MF
B - 116
K-9
A - 66
T-2
N - 23
A - 54
A - 93
K-4
B - 223
R -28
B - 28
N - 20
G – 16, G – 20, G
– 23, G – 24, G –
25, G - 27
B – 4, B – 155, B
– 196, B – 230, B
– 231, K - 10
A – 68, C – 84, C
– 87, D – 103, D
– 138
P – 3, P - 12
B - 128
B - 159
R -61
Z - 10
P-3
C – 4, O -6, U - 8
D - 12
C - 64
H – 14, J – 30, N
-4
V-7
K-7
B – 159, B – 211,
C – 54
P - 20
A – 82, R -30
D - 62
K-2
R -34
B - 212
B – 47, B – 55
D - 13
F - 12
B - 215
D - 110
B - 57
B – 152, B – 202,
B – 203, B – 204,
B – 233
J - 21
N - 36
D - 112
U - 39
D - 56
B - 84
C - 53
A - 104
R -38
B - 184
B - 150
U-6
B - 170
B - 229
C - 94
T - 47
R -13
C - 33
A-9
C - 50
I - 11
S-6
B - 246
A - 100
D - 77
B - 175
C – 98, Z - 21
D - 122
D - 48
B - 47
T - 24
D - 110
A – 41, A – 76, D
– 112, D - 115
D - 39
N - 25
B - 63
C - 61
F-5
A – 2, E -3
C - 12
C – 118, L - 3
B - 99
A - 82
R -33
O -17
C - 90
I – 9, I - 10
SANTOS MM
SANTOS MO
SANTOS MR
SANTOS MRV
SANTOS MT
SANTOS NF
SANTOS PCF
SANTOS RS
SANTOS RT
SANTOS TCP
SANTOS TG
SANTOS TM
SANTOS VM
SANTOS VT
SANTOSS DS
SARAIVA EM
SARAN PS
SARNO EN
SASSI FA
SASSONE-CORSI P
SAVINO W
SCABORA JE
SCARANO WR
SCARDUA PMS
SCHECHTMAN D
SCHENKMAN S
SCHER CR
SCHERHOLZ PLA
SCHICHOR CH
SCHMIDT EC
SCHNEIDER N
SCHOFFEN JPF
SCHULTZ TH
SCHULTZE E
SCHUNEMANN M
SCHUPBACH G
SCREIBER AZ
SCUDELER EL
SEABRA SH
SEDMAK B
SEGURA-VALDEZ ML
SEIXAS FK
SEONG-HO J
SERACHI FO
SERRÃO JE
SERVATO JPS
SEVERI-AGUIAR GDC
SHIMABUKURO MK
SHINOHARA EMG
SIGNORETTI PVP
SILVA AA
SILVA AAN
SILVA ACS
SILVA AH
SILVA AN
SILVA AO
SILVA AP
SILVA AR
SILVA ASF
SILVA BH
SILVA BJM
SILVA CG
SILVA CJ
SILVA CL
SILVA CM
SILVA CV
SILVA DC
SILVA DD
SILVA DF
SILVA DJ
SILVA DM
SILVA DRA
SILVA EAM
SILVA EL
SILVA EML
SILVA EO
SILVA ERM
SILVA FBF
SILVA FG
SILVA FILHO ACC
SILVA FP
SILVA FR
SILVA GAB
SILVA GET
SILVA GF
SILVA GHC
SILVA GM
D - 47
D - 27
F-7
A-9
P - 30
G - 21
A - 40
D – 111, R -59, U
-2
T - 83
R -35
T - 39
A – 71, D - 97
G - 20
A - 87
Z-9
J – 35, R -37
B - 39
L-5
B-4
D - 83
C – 83, I – 13, P 31
N - 14
D – 17, D – 37, D
– 45, D – 97, D –
99
B - 62
A - 25
A – 101, A – 102
Z-7
D - 88
Q -2
U – 24, U – 14, U
- 28
Z - 25
E -1, E -2, T - 20
P - 27
B - 213
U - 25
J - 45
S - 30
Z-2
R -24
T- 85
A - 118
B - 225
J - 17
B - 177
N – 3, V - 1
B - 11
D - 14
T – 82, Z - 32
O -5
Z-1
R -51
D - 119
B - 142
A - 72
C - 13
B – 114, B – 218
B - 120
D - 136
K-6
B - 205
R -66
A - 97
J – 31, U - 42
B - 101
T - 13
A – 40, A – 53, J
– 38, R -31, R 39, R -51, R -70
E -9
B - 140
B -24
N - 27
T - 61
G-6
R -14, R -18
J - 25
V - 10
A – 109, A - 111,
A - 113, A - 114,
A – 116, M -12,
R -66, R – 72, U 10
X -3
B - 164
C - 45
B - 27
B – 240, B – 242,
O -12
T - 23
N – 25, S - 17
M -5
F-9
D - 75
F - 10
SILVA IDCG
SILVA JAF
SILVA JG
SILVA JH
SILVA JPV
SILVA JR FP
SILVA JRMC
SILVA JÚNIOR RMP
SILVA KA
SILVA KEF
SILVA KR
SILVA LCF
SILVA LLP
SILVA LLR
SILVA LM
SILVA LM
SILVA LS
SILVA MA
SILVA MBB
SILVA MCC
SILVA MMM
SILVA MRD
SILVA MS
SILVA MT
SILVA NETA HL
SILVA NM
SILVA NS
SILVA PCM
SILVA PF
SILVA RB
SILVA RC
SILVA RF
SILVA RJ
SILVA RR
SILVA RRP
SILVA SA
SILVA SG
SILVA SV
SILVA TA
SILVA TG
SILVA TKA
SILVA TM
SILVA TP
SILVA VMM
SILVA WLB
SILVA-NETO A
SILVEIRA BS
SILVEIRA GF
SILVEIRA LTR
SILVEIRA MS
SILVEIRA NM
SILVEIRA PF
SILVEIRA-LACERDA EP
SILVESTRIN RB
SIQUEIRA AS
SIQUEIRA EE
SMAILI SS
SMANIOTTO S
SMANIOTTO S
SMITH RKW
SMUCZEK B
SOARES BM
SOARES CP
SOARES CP
SOARES FA
SOARES FAF
SOARES FLF
SOARES HM
SOARES JM
SOARES MAM
SOBRINHO MF
SOBRINHO PHG
SOCODATO R
SOGAYAR MC
SOGAYAR MC
SOLETTI RC
SOMASUNDARAM K
SONEHARA NM
SONODA MT
SOSTHENES MCK
SOUSA AL
SOUSA CEC
SOUSA CM
SOUSA LP
B – 77, B – 246, J
– 14, J – 36, O 10
I-6
B - 82
A - 77
C - 26
B - 28
A – 115, B – 120,
B – 121, I – 5, S 26
B - 161
B - 32
A – 110, E -12
Z - 20
P - 14
V - 10
R -57
B – 27, B – 33, C
-7
O -3, R -12, R -5,
Q -1, R -6, S –
10, Z - 3
T - 84
D - 136
A - 44
B - 91
P - 17
O -11
F - 18
C - 56
D - 10
R -41
G – 10, Z - 18
U-5
N-6
T - 60
C – 94, C – 116, J
- 47
A - 41
D-5
B - 241
M -12
D - 38
N-8
B – 73, C – 117
B - 168
B – 180, C – 106
X -2
T - 81
G - 33
B – 114, B – 118,
B – 185, B – 201
H-9
R -5, R -6
B - 110
B - 147
D - 45
F - 23
U - 34
A - 119
B - 210
T - 44
B – 125, B – 167
B - 141
G - 13
A – 30, P – 21, P
– 24, P – 33 U 29
Z - 38
B - 74
B – 234, U - 4
A – 7, B – 84, B –
141, B – 142, B –
182, B – 183, H 3
B - 39
S-4
U – 40, U - 41
L-6
B - 128
G-9
B - 90
A - 70
C - 76
B - 70
K – 14, Z - 5
C - 93
B - 46
C - 71
C - 46
N – 27, T – 26, T
- 48
D - 80
C - 113
A - 48
C – 26, I - 2
129
SOUZA AC
SOUZA ACF
SOUZA BC
SOUZA BK
SOUZA BL
SOUZA CRB
SOUZA EE
SOUZA FN
SOUZA FS
SOUZA IC
SOUZA JM
SOUZA JR PF
SOUZA KS
SOUZA LEL
SOUZA LM
SOUZA LOJ
SOUZA MC
SOUZA MVR
SOUZA NETO CPS
SOUZA NHC
SOUZA PAF
SOUZA RB
SOUZA SR
SOUZA TA
SPOHR TCLS
STEFFENS D
STERNBERG C
STIMAMIGLIO MA
STREIT JR DP
STUMPP T
STUR E
SUZUKI IL
TABOGA SR
TAMIR S
TANIWAKI NN
TANOWITZ HB
TARQUINIO SBC
TAVARES ALP
TAVARES E SILVA R
TAVARES MG
TEIXEIRA AD
TEIXEIRA BC
TEIXEIRA BL
TEIXEIRA C
TEIXEIRA CFP
TEIXEIRA FR
TEIXEIRA L
TEIXEIRA LCM
TEIXEIRA MM
TEIXEIRA S
TEIXEIRA SC
TENÓRIO DPLA
TERSARIOL ILS
TESSER RB
E -10
D - 33
C - 48
B – 230, B – 231
E -6
R -56
J-5
S - 11
E -7
A - 21
B - 80
D - 102
C – 44, D - 40
E -2
B - 233
T - 50
C - 109
B - 18
B - 145
C - 62
S - 10
S-7
U - 26
O -7
B - 69
Z - 12
B – 162, B – 188
Z - 34
N - 31
N – 5, N – 6
B - 92
F - 27
A – 70, A – 104,
D – 7, D – 9, D –
23, D – 51, D –
53, D – 100, D –
128, D – 133, D
– 137, N - 21
S - 13
C - 33
R -26
B - 169
N-2
X -9, X -10
S-4
N-3
C - 48
T - 41
C – 53, C – 57, C
– 59, C – 80, C 104
C - 82
X -4
C - 97
F - 24
C – 23, C – 24
T - 37
R -39
S-6
J - 33
N-5
THOMÉ R
TIAN X
TODESCHINI AR
TOLEDO DAM
TOLEDO PC
TOMIOSSO TC
TOMIYAMA L
TONELLI FMP
TONI KLG
TONIAZZO AP
TORRES AFC
TORRES AMH
TORRES DNM
TOSO VD
TRAVA-AIROLDI VJ
TRAVASSOS R
TRINDADE GS
TURCK P
TURRI JAO
UEIRA-VIEIRA C
URIAS U
UTIYAMA AH
VAGO AR
VALADÃO PAC
VALENCA SS
VALENTE SF
VALIM CXR
VALSECHI MC
VARELA JN
VAROTTI FP
VASCONCELOS RO
VECCHI L
VEIGA SS
VENDITE D
VENTURA ALM
VERAS PST
VERÇOZA BRF
VERGARA FMF
VERINAUD L
VERSUTE EM
VIANA AM
VIANA IMMN
VIANA MN
VIANI FC
VIANNA MCB
VIAU CM
VICENTINI CA
VICTONI T
VIDAL RS
VIEGAS GS
VIEIRA AM
VIEIRA JRC
VIEIRA LB
VIEIRA LFA
VIEIRA LN
C - 20
J-1
N - 45
R -55
O -14
P - 28
B - 96
Z - 17
D - 65
G - 28
G - 26
B - 138
Z - 40
A - 28
A-4
S - 24
B – 124, H - 8
Z - 24
B - 199
D - 121
B - 193
V-3
B – 32, B – 42, B
- 54
T-1
C - 88
R -14
R -25
B - 35
R -20, R -42
B - 34
B - 124
B - 174
A – 61, A – 86, A
– 103, P – 5, S –
11, X -7
T - 66
T – 80, T - 81
R -63, R -69, R 71
R -60
R -52
A – 5, C - 20
D - 90
U - 20
P - 24
C - 82
T - 54
A - 14
B – 202, B - 203
N – 44, N – 47, N
- 49
A - 80
B - 154
C - 17
B - 118
A – 110, B – 229,
E – 12
J - 44
P – 21, U - 29
U – 21, U - 22
VIEIRA NETO JP
VIEIRA PC
VIEIRA TSS
VILAÇA JA
VILANOVA-COSTA CAST
VILARDO AFRM
VILELA ALM
VILELA RC
VILLA-VERDE DMS
VILLODRE ES
VIOLA JPB
VIOTTO AC
VOLPE CMO
VOTTO APS
WARD LS
WATANABE I-S
WEINGRILL RB
WEIS SN
WEITKUNAT M
WERNECK CC
WILLE ACM
WINK MR
WIPPICH AC
WOO JC
WOSNIAK JÚNIOR J
WOZNIAK RW
XAVIER GF
XAVIER JM
YAMANOUYE N
YAN CYI
YONG-HO A
YOO J-O
YU-PEI C
ZACARO AA
ZAMBONI F
ZAMIN LL
ZAMPONI GW
ZANAROTTI GM
ZANETTI BF
ZANIER-GOMES PH
ZANON RG
ZAVAN B
ZEBDA N
ZEIDLER JD
ZENI EC
ZENKNER FF
ZINGALI RB
ZOGOVICH M
ZORÉL VJ
ZORN TNT
ZUCCARI DAPC
ZULIAN JG
ZUMA AA
ZÚÑIGA HAU
ZUZA AL
ZUZZI DC
ZYCH J
U-4
C - 68
J - 35
B - 111
B - 210
U - 36
B - 22
U-6
C - 98
B - 89
G – 39
G - 19
J - 18
B - 123
B - 102
T - 62
D - 139
G – 28, G - 29
N - 24
P - 22
A - 86
A – 69, B – 135,
B – 244, K – 9, Z
- 33
R -45
Z - 42
J - 24
B – 71
F - 24
B - 126
B – 81, J – 3, J - 7
N-19
J - 17
B - 53
G-2
B - 51
Z - 14
B - 23
J - 44
N - 32
K-3
T - 58
T - 24
D - 35
J-2
F-1
N - 38
S - 27
B - 144
S - 14
P-6
P-4
B – 100, B – 101,
B - 103
H-1
F - 13
A - 117
D - 130
P-1
O -13
130
Highlights:







Keynote Symposium by Steven Chu, U.S. Secretary of Energy, and Arthur D. Levinson, Chair,
Genentech, Inc., and Apple, Inc.
Threads (meetings-within-a-meeting):1) Cell Biology and Medicine and 2) Cell Biology and the
Physical Sciences. Daily programs will allow attendees to follow new fields while benefitting
from a large meeting with the best research in cell biology.
World-class Symposia and Minisymposia speakers
Frontier Symposia will synthesize current, exciting progress in the field
Science Discussion Tables—interact with senior scientists in an intimate setting
Posters, mentorship, networking, career development, and education programs
Fun in the wonderful city of San Francisco!
Important deadlines
July 23, 2012 (Application Deadline)
Special Interest Subgroup
July 30, 2012 (Application Deadline)
 Abstract submission (for Minisymposium or poster consideration)
September 4, 2012 (Application Deadline)
 Regular abstract submission (poster only)
October 10, 2012
 Early registration deadline

www.ascb.org
131

Programação do XVI Congresso da SBBC e 10th International

Transcrição

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