Curriculum Vitae

Curriculum Vitae
NAME
John Griffith Jones
E-MAIL
[email protected]
EDUCATION
Degree
University
Subject
Date
B. Sc.
University of
Stirling, Scotland
University of Texas
at Arlington
Biology and
Chemistry
Applied
Chemistry
June, 1985
D. Sc.
May, 1991
RESEARCH EXPERIENCE
1984-1985
Honours Thesis project, University of Stirling,
Scotland.
1986-1990
Graduate Thesis work at University of Texas at
Arlington.
Sept 1990-May 1991
Research Intern in the cataract research division at
Alcon Laboratories, Ft. Worth, TX.
1991-1995
Postdoctoral Research fellow at the Mary Nell and
Ralph B. Rogers Magnetic Resonance Center,
University of Texas Southwestern Medical Center,
Dallas.
1995-1997
Assistant Instructor of Radiology at the Mary Nell
and Ralph B. Rogers Magnetic Resonance Center.
1997-1999
Instructor of Radiology at the Mary Nell and Ralph
B. Rogers Magnetic Resonance Center.
1999-2002
Assistant Professor of Radiology at the Mary Nell
and Ralph B. Rogers Magnetic Resonance Center.
Nov 2000- Oct 2001
Marie Curie Experienced Researcher Fellow at the
Center for Neurosciences, University of Coimbra.
2002-present
Adjunct Faculty, Dept. of
Southwestern Medical Center.
Radiology,
U.T.
2002-present
Principal Investigator, Center for Neurosciences and
Cell Biology, University of Coimbra.
2002-present
Invited Assistant Professor at the Department of
Biochemistry, University of Coimbra.
MEMBERSHIPS
American Diabetes Association (since 2005)
European Association for the Study of Diabetes
(since 2005)
Portuguese Society of Diabetes (since 2005)
Marie Curie Fellows Association (since 2001)
AWARDS AND HONORS
2006
Portuguese Society of Diabetes 7th meeting, Best oral
communication in diabetes basic research.
2005
Portuguese Society of Diabetes-JABA Industry
Hargreaves Prize, Best Research Study on Diabetes
in Portugal in 2004.
2002
Portuguese Society of Gastroenterology XII meeting,
Best poster
2002
5º Reunião Anual da Associação Portuguesa para o
Estudo do Fígado (APEF), Best Poster.
TEACHING EXPERIENCE
1985-1988
Graduate Teaching Assistant in organic chemistry at
U.T. Arlington.
Summer, 1995
Lecturer: Biochemistry part 2, senior-level/graduate
course at U.T. Arlington.
Autumn, 2001
Guest Lecturer in the Analytical Biochemistry 3rd
year course and the Analytical Biochemistry Practical
2nd year course at the Department of Biochemistry,
University of Coimbra.
Spring, 2002
Co-organizer and Lecturer in the CNC advanced
studies course “Metabolic Studies of Cells and
Organs using Stable Isotopes and NMR.”
AREAS OF EXPERTISE
Analysis of human hepatic metabolism using stable
isotope tracers and NMR spectroscopy.
Quantification of deuterium and carbon-13 labeling
patterns in biological systems by NMR methods.
Development of metabolic models for analysis of
intermediary metabolism.
CURRENT INTERESTS
Development of stable isotope tracer methods for
measuring human hepatic metabolism in a
conventional hospital setting.
Understanding the role of the Krebs cycle in hepatic
glucose metabolism.
PATENTS
U.S. Patent No 6,329,208 issue date 11/12/01
“Methods
for
determining
gluconeogenesis,
anapleurosis and pyruvate recycling”.
RESEARCH FUNDING:
Recent Award (Principal Investigator):
Juvenile Diabetes Research Foundation International – Innovative Grant (5-2004-306)
“Noninvasive assessment of hepatic glycogen metabolism in Type 1 diabetics”. $49,269,
April 1 2004-July 31 2005.
Current Awards (Principal Investigator):
Portuguese Foundation of Science and Technology (POCTI/QUI/55603) “Hepatic
intermediary metabolism of glucose in children with and without hepatic glucose-6phosphatase activity”. €65,500, Oct 1 2005-Sept 30 2007.
Juvenile Diabetes Research Foundation International – Regular Research Grant (1-200674) “Noninvasive measurement of hepatic glycogen kinetics in Type 1 diabetics”.
$315,104, May 1 2006-April 30 2008.
Portuguese Foundation of Science and Technology- Luso-Espanhola Collaborative
Actions “Noninvasive NMR studies of organ function with stable isotope tracers and
contrast agents”. € 2,793, Jan 1 2006-Dec 31 2007.
PUBLICATIONS 2002-2006
1.
Duarte, I.F., Goodfellow, B.J., Barros, A., Jones, J.G., Barosa, C., Diogo, L.,
Garcia, P. and Gil, A.M., 2006. Metabolic characterisation of plasma in
juveniles with glycogen storage disease type 1a (GSD1a) by high
resolution 1H NMR spectroscopy. NMR in Biomedicine, (in press).
2.
Jones, J.G., Fagulha,A., Barosa, C., Bastos, M., Barros, L., Baptista, C.,
Caldeira M., and Carvalheiro M. 2006. Noninvasive analysis of
hepatic glycogen kinetics before and after breakfast with deuterated water
and acetaminophen. Diabetes, 55, 2294-2300.
3.
Jones, J.G., Barosa, C, Gomes, F., Mendes, A.C., Delgado, T.C., Diogo, L., Garcia, P.,
Bastos, M., Barros, L., Fagulha, A., Baptista, C., Carvalheiro, M. and Caldeira, M.M.
2006. NMR derivatives for quantification of 2H and 13C-enrichment of human
glucuronide from metabolic tracers. J. Carbohydrate Chem. 25, 203-217.
4.
Delgado, T.C., Tomaz, A.I., Correia, I., Pessoa, J.C., Jones, J.G., Geraldes, C.F.G.C.
and Castro, M.M.C.A. 2005. Uptake and metabolic effects of insulin mimetic
oxovanadium compounds in human erythrocytes. J. Inorg. Biochem. 99, 23282339.
5.
Fonseca, C.P., Jones, J.G., Carvalho, R.A., Jeffrey, F.M.H., Montezinho, L.P.,
Geraldes C.F.G.C., Castro, M.M.C.A. 2005. Tricarboxylic acid cycle inhibition by
Li+ in SH-SY5Y human neuroblastoma cell line: a 13C NMR isotopomer analysis.
Neurochem. International 47, 385-393.
6.
Ribeiro, A., Caldeira, M.M., Carvalheiro, M., Bastos, M., Baptista, C., Fagulha, A.,
Barros, L., Barosa, C. And Jones, J.G. 2005. A simple measurement of
gluconeogenesis by direct 2H NMR analysis of menthol glucuronide enrichment
from 2H2O. M. R. M. 54, 429-434.
7.
Eunsook S.J., Jones, J.G., Burgess, S.C., Merritt, M.A., Sherry, A.D. and Malloy,
C.R. 2005. Comparison of [3,4-13C2]glucose to [6,6-2H2]glucose as a tracer for
glucose turnover by NMR. M. R. M. 53 1479-1483.
8.
Delgado, T.C., Castro, M.M., Geraldes, C.F. and Jones, J.G. 2004. Quantitation of
erythrocyte pentose phosphate pathway flux with [2-13C]glucose and 1H NMR
analysis of the lactate methyl signal. M. R. M. 51, 1283-1286.
9.
Eunsook S.J., Jones, J.G., Merritt, M.A., Burgess, S.C., Malloy, C.R. and Sherry,
A.D. 2004. Glucose production, gluconeogenesis, and hepatic TCA cycle fluxes
measured by NMR analysis of a single glucose derivative. Anal. Biochem 327, 149155.
10.
Perdigoto, R., Rodrigues, T.B., Furtado, A.L., Porto, A., Geraldes, C. F. G. C. and
Jones, J.G. 2003. Integration of [U-13C]glucose and 2H2O for quantification of
hepatic glucose production and gluconeogenesis. NMR in Biomedicine 16, 189-198.
11.
Perdigoto, R., Furtado, A.L., Porto, A., Rodrigues, T.B., Geraldes, C. F. G. C. and
Jones, J.G. 2003. Sources of glucose production in cirrhosis by 2H2O ingestion and
2H NMR analysis of plasma glucose. B.B.A. Mol. Medicine, 1637, 156-163.
12.
Burgess, S.C., Weis, B., Jones, J.G., Smith, E., Merritt, M.A., Margolis, D., Sherry,
A.D. and Malloy, C.R. 2003. Noninvasive evaluation of liver metabolism by
2
H and 13C NMR isotopomer analysis of human urine. Anal. Biochem. 312, 228-234.
13.
Jones, J.G., Perdigoto, R., Rodrigues, T.B. and Geraldes, C.F.G.C. 2002.
Quantitation of absolute 2H enrichment of plasma glucose by 2H NMR analysis
of its monoacetone derivative. M. R. M. 48, 535-539.
14.
Carvalho, R.A., Jones, J.G., McGuirk, C., Sherry, A.D. and Malloy, C.R. 2002.
Hepatic gluconeogenesis and Krebs cycle fluxes in a CCl4 model of acute liver
failure. NMR in Biomedicine , 15, 45-51.