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Oferta de Tecnologia Difusão Internacional Título COMPOUNDS WITH ANTI-PARASITE ACTIVITY (PAT13) Referência 43304 Procura válida até 19-08-2016 Resumo This technology concerns to the application of new compounds with a potent anti-parasite activity against leishmaniasis causing organisms: Bisnaphthalimidopropyl (BNIP) derivatives Descrição Naphthalimido derivatives exhibit considerable potential anti-parasite activity. To realise this potential and to enhance the activity of such compounds, most previous research has been focused on the modification of the naphthalimido ring structure through increased DNA binding and cleavage. We have now created a number of new bisnapthalimidopropyl (BNIP) derivatives characterised by the use of natural polyamine linkers between the BNIP fragments. The family of new derivatives differ in respect of their respective alkyl linker chain lengths and nitrogen atom content. Compared to previous derivatives, these compounds have enhanced water solubility and now show potent in vitro and in vivo anti-proliferative effects on the life cycle of the protozoans Leishmania infantum, Trypanosoma brucei and T. cruzi, the causative agents of leishmaniasis, sleeping disease and Chagas disease, respectively,in humans. Aspectos Inovadores e Principais Vantagens da Oferta - Natural polyamine structures are the basis of the BNIP derivatives with alkyl linker chains; - Enhanced water solubility due to the alkyl chain length and charge distribution; - High yeild chemical synthetic strategies established; - Advanced nanoformulation technologies compatibility; - Potent in vitro and in vivo anti-trypanosomal (anti-Leishmania, anti-T.brucei and anti-T. cruzi) activity; Fase de Desenvolvimento Projeto iniciado Comentários à fase de desenvolvimento Compounds have undergone in vitro and in vivo studies. In vitro assays: the nanoformulation reduced the compound cellular toxicity, retained its potent anti-leishmanial activity. In vivo assays: the BNIP derivative nanoformulation is more effective than free compound and amphotericin B in the spleen; in the liver the effect of the BNIP derivative nanoformulation is less pronunced. Direitos de Propriedade Industrial Patente atribuída Comentários aos Direitos de Propriedade Industrial Patent granted in Portugal, USA and Europe (France, Germany, Spain and United Kingdom) Exploração de resultados de I&D Nenhum Comentários à exploração de resultados de I&D We are seeking business partners for licensing or assignment agreement. Tipos de Colaboração Acordo de licenciamento Contrato de aquisição Tipo de parceiro procurado Business company; investor Área de actividade do parceiro Any interested in the potential of the technology Tarefa a ser realizada Development and commercialisation 01-10-2016 http://www.bolsatecnologia.pt 1/2 Aplicação de Mercado Pharmaceutical Industry Descrição da Organização UPorto Innovation is the Knowledge Transfer Office of University of Porto, Portugal. It is in charge of patent exploration, marketing promising innovations and entrepreneurship opportunities, and acts as an interface with companies. 01-10-2016 http://www.bolsatecnologia.pt 2/2
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