blood12116toc 7..10

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18 APRIL 2013 x VOLUME 121, NUMBER 16
CONTENTS
COVER FIGURE
May-Grünwald Giemsa staining of progeny of CD341 cells following MASL1knockdown at day 14 of EPO-induced erythroid differentiation showing impaired
erythroid differentiation. See the article by Kumkhaek et al on page 3216.
EDITORIAL
3059
Epigenetics in hematology: introducing a collection of reviews
M. A. Goodell
INSIDE BLOOD
3061
CD39 target practice
D. K. Newman
3062
Multiethnic myeloma
B. M. Weiss
3064
Another path to ERK activation
P. A. Ney
BLOOD WORK
3066
Hereditary elliptocytosis
C. Soderquist and A. Bagg
PLENARY PAPER
3067
Delayed targeting of CD39 to activated platelet GPIIb/IIIa via a single-chain
antibody: breaking the link between antithrombotic potency and bleeding?
J. D. Hohmann, X. Wang, S. Krajewski, C. Selan, C. A. Haller, A. Straub, E. L. Chaikof,
H. H. Nandurkar, C. E. Hagemeyer, and K. Peter
REVIEW SERIES
3076
Epigenetics in Hematology
malignant hematopoiesis
The role of chromatin modifiers in normal and
J. S. Butler and S. Y. R. Dent
HOW I TREAT
3085
How I treat patients with indolent and smoldering mastocytosis (rare conditions but
difficult to manage)
A. Pardanani
CLINICAL TRIALS AND
OBSERVATIONS
3095
Phase 2 study of arsenic trioxide followed by autologous hematopoietic cell
transplantation for relapsed acute promyelocytic leukemia
M. Yanada, M. Tsuzuki, H. Fujita, K. Fujimaki, S. Fujisawa, K. Sunami, M. Taniwaki,
A. Ohwada, K. Tsuboi, A. Maeda, A. Takeshita, S. Ohtake, Y. Miyazaki, Y. Atsuta, Y. Kobayashi,
T. Naoe, and N. Emi, on behalf of the Japan Adult Leukemia Study Group
IMMUNOBIOLOGY
3103
IL-21–stimulated human plasmacytoid dendritic cells secrete granzyme B, which
impairs their capacity to induce T-cell proliferation
J. J. Karrich, L. C. M. Jachimowski, M. Nagasawa, A. Kamp, M. Balzarolo, M. C. Wolkers,
C. H. Uittenbogaart, S. M. van Ham, and B. Blom
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3112
B-cell deficiency and severe autoimmunity caused by deficiency of protein kinase C d
E. Salzer, E. Santos-Valente, S. Klaver, S. A. Ban, W. Emminger, N. K. Prengemann,
W. Garncarz, L. Müllauer, R. Kain, H. Boztug, A. Heitger, K. Arbeiter, F. Eitelberger,
M. G. Seidel, W. Holter, A. Pollak, W. F. Pickl, E. Förster-Waldl, and K. Boztug
3117
Loss-of-function of the protein kinase C d (PKCd) causes a B-cell lymphoproliferative
syndrome in humans
H. S. Kuehn, J. E. Niemela, A. Rangel-Santos, M. Zhang, S. Pittaluga, J. L. Stoddard,
A. A. Hussey, M. O. Evbuomwan, D. A. L. Priel, D. B. Kuhns, C. L. Park, T. A. Fleisher,
G. Uzel, and J. B. Oliveira
3126
Overexpression of miR-155 causes expansion, arrest in terminal differentiation and
functional activation of mouse natural killer cells
R. Trotta, L. Chen, S. Costinean, S. Josyula, B. L. Mundy-Bosse, D. Ciarlariello, C. Mao,
E. L. Briercheck, K. K. McConnell, A. Mishra, L. Yu, C. M. Croce, and M. A. Caligiuri
3135
Murine natural killer immunoreceptors use distinct proximal signaling complexes to
direct cell function
R. M. May, M. Okumura, C.-J. Hsu, H. Bassiri, E. Yang, G. Rak, E. M. Mace, N. H. Philip,
W. Zhang, T. Baumgart, J. S. Orange, K. E. Nichols, and T. Kambayashi
LYMPHOID NEOPLASIA
3147
Uncovering the biology of multiple myeloma among African Americans:
a comprehensive genomics approach
A. Baker, E. Braggio, S. Jacobus, S. Jung, D. Larson, T. Therneau, A. Dispenzieri,
S. A. Van Wier, G. Ahmann, J. Levy, L. Perkins, S. Kim, K. Henderson, D. Vesole,
S. V. Rajkumar, D. F. Jelinek, J. Carpten, and R. Fonseca
3153
Incidence and prognostic relevance of genetic variations in T-cell lymphoblastic
lymphoma in childhood and adolescence
B. R. Bonn, M. Rohde, M. Zimmermann, D. Krieger, I. Oschlies, F. Niggli, G. Wrobel,
A. Attarbaschi, G. Escherich, W. Klapper, A. Reiter, and B. Burkhardt
3161
Brief Report The E3 ubiquitin ligase UBR5 is recurrently mutated in mantle
cell lymphoma
B. Meissner, R. Kridel, R. S. Lim, S. Rogic, K. Tse, D. W. Scott, R. Moore, A. J. Mungall,
M. A. Marra, J. M. Connors, C. Steidl, and R. D. Gascoyne
MYELOID NEOPLASIA
3165
Activity of ponatinib against clinically-relevant AC220-resistant kinase domain
mutants of FLT3-ITD
C. C. Smith, E. A. Lasater, X. Zhu, K. C. Lin, W. K. Stewart, L. E. Damon, S. Salerno,
and N. P. Shah
3172
Higher bone marrow LGALS3 expression is an independent unfavorable prognostic
factor for overall survival in patients with acute myeloid leukemia
C.-L. Cheng, H.-A. Hou, M.-C. Lee, C.-Y. Liu, J.-Y. Jhuang, Y.-J. Lai, C.-W. Lin, H.-Y. Chen,
F.-T. Liu, W.-C. Chou, C.-Y. Chen, J.-L. Tang, M. Yao, S.-Y. Huang, B.-S. Ko, S.-J. Wu,
W. Tsay, and H.-F. Tien
3181
Brief Report Naturally occurring oncogenic GATA1 mutants with internal
deletions in transient abnormal myelopoiesis in Down syndrome
T. Toki, R. Kanezaki, E. Kobayashi, H. Kaneko, M. Suzuki, R. Wang, K. Terui, H. Kanegane,
M. Maeda, M. Endo, T. Mizuochi, S. Adachi, Y. Hayashi, M. Yamamoto, R. Shimizu, and E. Ito
PHAGOCYTES,
GRANULOCYTES, AND
MYELOPOIESIS
3185
Selective inhibition of the NLRP3 inflammasome by targeting to promyelocytic
leukemia protein in mouse and human
Y.-H. Lo, Y.-W. Huang, Y.-H. Wu, C.-S. Tsai, Y.-C. Lin, S.-T. Mo, W.-C. Kuo, Y.-T. Chuang,
S.-T. Jiang, H.-M. Shih, and M.-Z. Lai
viii
BLOOD, 18 APRIL 2013 x VOLUME 121, NUMBER 16
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3195
Aryl hydrocarbon receptor controls murine mast cell homeostasis
Y. Zhou, H.-Y. Tung, Y.-M. Tsai, S.-C. Hsu, H.-W. Chang, H. Kawasaki, H.-C. Tseng,
B. Plunkett, P. Gao, C.-H. Hung, B. M. Vonakis, and S.-K. Huang
PLATELETS AND
THROMBOPOIESIS
3205
The calcineurin-NFAT pathway negatively regulates megakaryopoiesis
A. Zaslavsky, S. T. Chou, K. Schadler, A. Lieberman, M. Pimkin, Y. J. Kim, K.-H. Baek,
W. C. Aird, M. J. Weiss, and S. Ryeom
RED CELLS, IRON, AND
ERYTHROPOIESIS
3216
MASL1 induces erythroid differentiation in human erythropoietin-dependent CD341
cells through the Raf/MEK/ERK pathway
C. Kumkhaek, W. Aerbajinai, W. Liu, J. Zhu, N. Uchida, R. Kurlander, M. M. Hsieh, J. F. Tisdale,
and G. P. Rodgers
3228
The secreted lymphangiogenic factor CCBE1 is essential for fetal liver erythropoiesis
Z. Zou, D. R. Enis, H. Bui, E. Khandros, V. Kumar, Z. Jakus, C. Thom, Y. Yang, V. Dhillon,
M. Chen, M. Lu, M. J. Weiss, and M. L. Kahn
3237
Genetic mapping and exome sequencing identify 2 mutations associated with stroke
protection in pediatric patients with sickle cell anemia
J. M. Flanagan, V. Sheehan, H. Linder, T. A. Howard, Y.-D. Wang, C. C. Hoppe, B. Aygun,
R. J. Adams, G. A. Neale, and R. E. Ware
3246
Isolation and functional characterization of human erythroblasts at distinct stages:
implications for understanding of normal and disordered erythropoiesis in vivo
J. Hu, J. Liu, F. Xue, G. Halverson, M. Reid, A. Guo, L. Chen, A. Raza, N. Galili, J. Jaffray,
J. Lane, J. A. Chasis, N. Taylor, N. Mohandas, and X. An
THROMBOSIS AND
HEMOSTASIS
3254
Evidence that fibrinogen g9 regulates plasma clot structure and lysis and relationship
to cardiovascular risk factors in black Africans
M. Pieters, R. C. Kotze, J. C. Jerling, A. Kruger, and R. A. S. Ariëns
TRANSFUSION MEDICINE
3261
CME Article Low-level HLA antibodies do not predict platelet transfusion failure
in TRAP study participants
R. P. Jackman, X. Deng, D. Bolgiano, M. Lebedeva, J. W. Heitman, M. P. Busch, S. J. Slichter,
and P. J. Norris
TRANSPLANTATION
3267
Novel interferon-based pre-transplantation conditioning in the treatment of
a congenital metabolic disorder
T. Sato, M. Ikeda, S. Yotsumoto, Y. Shimada, T. Higuchi, H. Kobayashi, T. Fukuda, T. Ohashi,
T. Suda, and T. Ohteki
3274
Donor-derived regulatory B cells are important for suppression of murine
sclerodermatous chronic graft-versus-host disease
D. Le Huu, T. Matsushita, G. Jin, Y. Hamaguchi, M. Hasegawa, K. Takehara, T. F. Tedder,
and M. Fujimoto
3284
Brief Report TP53, SF3B1, and NOTCH1 mutations and outcome of
allotransplantation for chronic lymphocytic leukemia: six-year follow-up of the
GCLLSG CLL3X trial
P. Dreger, A. Schnaiter, T. Zenz, S. Böttcher, M. Rossi, P. Paschka, A. Bühler, S. Dietrich,
R. Busch, M. Ritgen, D. Bunjes, M. Zeis, M. Stadler, L. Uharek, C. Scheid, U. Hegenbart,
M. Hallek, M. Kneba, N. Schmitz, H. Döhner, and S. Stilgenbauer
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VASCULAR BIOLOGY
3289
VCAM-1 and VAP-1 recruit myeloid cells that promote pulmonary metastasis
in mice
Š. Ferjančič, A. M. Gil-Bernabé, S. A. Hill, P. D. Allen, P. Richardson, T. Sparey, E. Savory,
J. McGuffog, and R. J. Muschel
RETRACTIONS
3298
Zhang C, Yang Y. Microparticles are the basic storage units for different proteins in
platelet granules [published online ahead of print July 24, 2012]. Blood. doi: 10.1182/
blood-2012-04-422907.
CONTINUING MEDICAL EDUCATION (CME) QUESTIONS
3299
HLA Abs and platelet refractoriness
OTHER DEPARTMENTS
xxiii
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2013 121: 3059-3299
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