prolonged use of dermosonic lipoclasia for reduction of

PROLONGED USE OF DERMOSONIC LIPOCLASIA FOR REDUCTION OF
SUBCUTANEOUS FAT INCREASES CARDIOMETABOLIC RISK IN
HEALTHY RATS: PRECLINICAL STUDIES
JN Correia, BB Jacobsen, PW Endlich, SA Gouvea, AN Rodrigues, GR Abreu, MR Moyses,
WLS Goncalves.
Centro Universitário do Espírito Santo – UNESC, Colatina, ES, Brasil.
Universidade Federal do Espírito Santo – UFES, Vitoria, ES, Brasil.
ABSTRACT
Objectives: In recent years in Brazil has increased significantly the use of lipoclasia
dermosonic (LCD, subcutaneous lipolysis by ultrasound) as a treatment for skin disorders,
especially lipodystrophy gynoid. However, the systemic effects of prolonged use of the LCD are
not yet well established. In this study the objective was to investigate the cardiovascular and
metabolic effects of prolonged use of LCD for reduction of subcutaneous fat in female rats.
Methods and Results: Healthy female rats (Wistar) were divided into two groups, named
control (n=20) and treated with LCD (n=20). After 10 days, ½ of the female rats in both
experimental groups were sacrificed and evaluated; the others remained for another 10 days
washout period for the effects of the LCD. For the treatment of animals used were 10
applications of LCD on alternate days, the following parameters: ISATA= 3MHz, 1W.cm-2,
pulsed mode (2ms ON: OFF 8ms), cycle 30% for 3 minutes in 3cm2 of inguinal subcutaneous
adipose tissue. Cardiovascular and metabolic parameters were evaluated during stages of the
study. Body composition was measured using bioimpedance and bilateral lipectomy, and
biochemical profile and inflammatory response plasma were determined. The LDC reduces
(P<0.05) body composition and fat deposits, changes the cardiovascular parameters (P<0.05),
causes dyslipidemia and peripheral insulin resistance with increased inflammatory response in
healthy female rats.
Conclusions: The LCD shows potential as an inducer of subcutaneous lipolysis, however,
prolonged use appears to increase the cardiometabolic risk factors in female rats.
Keywords: Lipoclasia dermosonic, Lipolysis, dyslipidaemia, insulin resistance, cardiovascular
risk.