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Angelina Sá Palma
Curriculum vitæ
PERSONAL DATA
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Nationality:
Date and Place of Birth:
Institutional address:
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Maria Angelina de Sá Palma
Portuguese
th
August 5 , 1975; Neumünster (Germany)
REQUIMTE/CQFB Departamento de Química, FCT/UNL
Campus da Caparica
2829-516 Monte da Caparica
PORTUGAL
+351 212948300; ext-10962; mobile: +351 7851662
[email protected]; [email protected]
http://www.researcherid.com/rid/D-2052-2013
http://www.ucibio.pt/people/angelinapalma
http://xtal.dq.fct.unl.pt/members.html
ACADEMIC DEGREES
2007
2001
PhD in Biochemistry at Institute of Chemical and Biological Chemistry/New University of Lisbon
(ITQB/UNL).
Title of the thesis: “Amyotrophic Lateral Sclerosis: Identification and Characterisation of Biochemical
and Molecular Markers”; Supervisor Dr. Júlia Costa.
Degree in Biochemistry from Faculty of Science and Technology, University of Algarve, Portugal.
Thesis research at the Glycobiology Laboratory, ITQB/UNL, Oeiras; Supervisor Dr. Júlia Costa. Final
mark: 19/20.
Title of the thesis: “Purification and enzymatic and biochemical characterization of human α3/4Fucosyltransferase III (EC 2.4.1.65)”. Final mark: 19/20
RESEARCH ACTIVITY
2013 (July) to present
2013 (July) to present
2009 (May) to April 2013
2009 (May) to present
2007 (May) to 2009 (Apr)
2003 (Oct) to 2004 (Dec)
2002 (Mar) to 2007 (Mar)
2000 (Nov) to 2002 (Feb)
1999 (Sep) to 2000 (Dec)
Assistant Researcher at REQUIMTE, FCT/UNL
FCT Investigator Position at REQUIMTE, FCT/UNL (Starting Grant)
Post-doctoral Research Fellow at the Protein Crystallography Group, Science
and Technology Faculty (FCT)/UNL, Associated Laboratory REQUIMTE.
Honorary Research Associate at the Glycosciences Laboratory,
Imperial College London.
Post-doctoral Research Fellow at the Glycosciences Laboratory
Imperial College London.
Visiting Scholar at the Glycosciences Laboratory
Imperial College London.
PhD student at the Glycobiology Laboratory, ITQB/UNL.
Initiation to Science Research Fellow at the Glycobiology Laboratory
ITQB/UNL.
Undergraduate student in biochemistry at the Glycobiology Laboratory
ITQB/UNL.
AWARDS & FELLOWSHIPS
2013
2008
2007
2002
Santander-Totta/UNL Scientific Merit award (2012/2013 Edition) “Antibody Engineering for the
Treatment of Breast Cancer” (Co-PI)
Travel Fund Award from the Glycobiology Society
6-year post-doctoral research fellowship from Portuguese Foundation for Science and
Technology (FCT); SFRH/BPD/26515/2006.
4-year post-graduate research fellowship from FCT; SFRH/BD/6506/2001.
EXPERTISE
In oligosaccharide isolation and analysis; preparation of probes (neoglycolipids) for glycoarray printing; in
microarray generation and probing with soluble carbohydrate-binding proteins (single domains or
complexes), virus particles and human or mouse serum; analysis of microarray data for specificity
assignments and carbohydrate-ligand discovery; immuno-assays; protein purification and analysis methods;
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recombinant protein expression; protein crystallization; proteomics of human plasma and cerebrospinal fluid;
post-translational modifications analysis, namely glycosylation; and in manipulation of mammalian cells.
CURRENT RESEARCH INTERESTS
Carbohydrate-ligand discovery for recognition systems of biological, biomedical and biotechnological
importance using carbohydrate microarrays; structural analysis of the protein-carbohydrate interaction by
protein X-ray crystallography; neoglycolipid-based oligosaccharide microarray technology; ‘designer’
microarrays from microbial and plant polysaccharides (Glucans, LPS and others,); glucan-binding proteins of
the immune system e.g. Dectin-1; lectin-carbohydrate interaction in the immune system; mammalian and
microbial carbohydrate binding proteins (e.g. lectins, CBMs and glycoside hydrolases, antibodies); hostpathogen interactions mediated by carbohydrate recognition; cancer-associated carbohydrate antigens;
recombinant protein expression; protein crystallization; protein and protein-ligand structure determination.
SOCIETY MEMBERSHIP
Member of the Portuguese Biochemical Society (SPB) since 1999
Member of the Glycobiology Society since 2008
Member of INSTRUCT since 2011
EXPERIENCE AS SCIENTIFIC ADVISER
Co-supervision of a PhD student
-Lisete Silva - 2010-2014 Thesis entitled: “Structural characterization and generation of microarrays of
Helicobacter pylori cell surface glycans”, in collaboration with Prof. Manuel Coimbra, Chemistry Department,
University of Aveiro (SFRH/BD/71455/2010).
Supervison of a Traineeship in the scope of Biochemistry degree
-Mariana Romão - FCT/UNL 2011-2012 "Caracterização estrutural, por Cristalografia de Raios-X, da
Malectina humana em complexo com ligandos oligossacáridos"
Invited juri in Master Thesis
-Joana Cabral, ICBAS-Universidade do Porto, 2011. "The role of N-acetylglucosyltransferase III and V in
modulation of E-cadherin in cancer.
-Mariana Silva, FCT/UNL , 2011. "Impacto de antigénios glicosídicos na imunoterapia aplicada em cancro
de bexiga"
GRANTS AND R&D PROJECTS
As Principal Investigator:
2013- FCT Investigator Starting Grant
2013-2014- "Pylori GlycoArrays: Development of microarrays from Helicobacter pylori cell surface glycome
toward immunological and serological studies" EXPL/BBB-BQB/0750/2012, funded by FCT, Portugal.
2011-2014 “A carbohydrate microarray platform for discovery of ligands in polysaccharides recognised by
microbial carbohydrate-binding modules” PTCD/QUI/QUI/112537/2009, funded by FCT, Portugal.
As a team member:
2013-2015 – “Modern Structural Biology: Resources for the advancement of in-house X-ray Crystallography"
RECI/BBB-BEP/0124/2012, funded by FCT, Portugal.
2013-2014- "Development of cohesin- microarrays for determining cohesin-dockerin specificities of novel
cellulolytic species" EXPL/BBB-BEP/0506/2012, funded by FCT, Portugal.
2004-2007: “STREP - Signaling and Membrane Trafficking in Transformation and Differentiation”, LSHG-CT2004-503228, funded by 6th Framework Programme, EU.
2003-2005: “Clinical, Neurophysiological and Neurochemical studies in Amyotrophic Lateral Sclerosis",
POCTI/CBO/43952/2002, funded by FCT, Portugal
2002-2005: “Identificação e caracterização de proteínas envolvidas na organização do Golgi de células de
mamífero” POCTI/BCI/38631/99, funded by FCT, Portugal.
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1999-2001: “Glicosilação das mucinas na mucosa gástrica normal, carcinoma gástrico e linhas celulares de
carcinoma gástrico: papel da glicosilação e das apomucinas” PRAXIS/SAU/14111/1998, funded by FCT,
Portugal.
PUBLISHED WORKS
THESIS
- Angelina S. Palma (2007) “Amyotrophic Lateral Sclerosis: Identification and Characterisation of
Biochemical and Molecular Markers, to obtain the PhD in Biochemistry at ITQB/UNL.
- Angelina S. Palma (2000) “Purification and enzymatic and biochemical characterization of the human
alpha3/4-fucosyltransferase III (EC 2.4.1.65)”- final thesis of Biochemistry degree, Faculdade de Ciências e
Tecnologia da Universidade do Algarve, Portugal.
CHAPTERS IN BOOKS
1. Palma, A.S*., Zhang, Y., Childs, R.A., Campanero-Rhodes, M.A., Liu, Y., Feizi, T., Chai, W.
“Neoglycolipid-Based "Designer" Oligosaccharide Microarrays to Define ß-Glucan Ligands for
Dectin-1”. Yann Chevolot (ed.), Carbohydrate Microarrays: Methods and Protocols, Methods in
Molecular Biology, Volume 808, Chapter 23:337-59, 2012 (*Corresponding author).
2. Liu, Y., Childs, R.A., Palma, A.S., Campanero-Rhodes, M.A., Stoll, M.S., Chai, W., Feizi, T.
“Neoglycolipid-Based Oligosaccharide Microarray System: Preparation of NGLs and Their
Noncovalent Immobilization on Nitrocellulose-Coated Glass Slides for Microarray Analyses”. Yann
Chevolot (ed.), Carbohydrate Microarrays: Methods and Protocols, Methods in Molecular Biology,
Volume 808, Chapter 8:117-36, 2012
3. Palma, A.S., Liu, Y., Muhle-Goll, C., Butters, T.D., Zhang, Y., Childs, R., Chai, W., Feizi, T.
"Multifaceted approaches including neoglycolipid oligosaccharide microarrays to ligand discovery for
malectin". Methods in Enzymology, Elsevier Inc. Volume 478, Chapter 13: 265-86, 2010
PAPERS IN INTERNATIONAL SCIENTIFIC PERIODICALS WITH REFEREES
1. Palma, A.S., Feizi, T., Childs, R.A, Chai, W. and Liu, Y. “The neoglycolipid (NGL)-based
oligosaccharide microarray system poised to decipher the meta-glycome”. Curr Opin Chem Biol, In
press.
2. Neu, U., Allen, S.A., Blaum, B.S., Liu, Y., Frank, M., Palma, A.S., Ströh, L.J., Feizi, T., Peters T.,
Atwood, W.J., Stehle, T. “A structure-guided mutation in the major capsid protein retargets BK
Polyomavirus”. PLoS Pathog 9:e1003688, 2013
3. Neu, U., Mahmood Khan, Z., Schuch, B., Palma, A.S., Liu, Y., Pawlita, M., Feizi, T., Stehle, T.
“Structures of B-Lymphotropic Polyomavirus VP1 in complex with oligosaccharide ligands”. PLoS
Pathog 9:e1003714, 2013.
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4. Crusat, M ., Liu, J ., Palma, A.S ., Childs, R.A ., Liu, Y ., Wharton, S.A., Lin, Y.P., Coombs, P.J.,
Martin, S.R., Matrosovich, M., Chen, Z., Stevens, D.J., Hien, V.M., Thanh, T.T., Nhu, L.N., Nguyet,
L.A., Ha, D.Q., van Doorn, H.R., Hien, T.T., Conradt, H.S., Kiso, M., Gamblin, S.J., Chai, W., Skehel,
J.J., Hay, A.J., Farrar, J., de Jong, M.D., Feizi, T. Changes in the hemagglutinin of H5N1 viruses
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during human infection - Influence on receptor binding. Virology, 447: 326-337, 2013 ( co-first
authors).
5. Graham, L.M., Gupta, V., Schafer, G., Reid, D.M., Kimberg, M., Dennehy, K.M., Hornsell, W.G.,
Guler, R., Campanero-Rhodes, M.A., Palma, A.S., Feizi, T., Kim, S.K., Sobieszczuk, P., Willment,
J.A., Brown, G.D. “The C-type lectin receptor CLECSF8 (CLEC4D) is expressed by myeloid cells
and triggers cellular activation through Syk kinase.”J Biol Chem. 287:25964-74, 2012.
6. Lai, L., Bumstead, J., Liu, Y., Garnett, J., Campanero-Rhodes, M.A., Blake, D.P., Palma, A.S., Chai,
W., Ferguson, D.J., Simpson, P., Feizi, T., Tomley, F.M., Matthews, S. “The Role of Sialyl Glycan
Recognition in Host Tissue Tropism of the Avian Parasite Eimeria tenella”.PLoS Pathog. Oct;
7(10):e1002296, 2011.
7. Feizi, T., Liu, Y., Palma, A.S. “Bacterial, Fungal, and Algal Lectins: Combatants in Tug of War
against HIV”, Structure. 19:1035-7, 2011.
8. Watson, A.A., Lebedev, A.A., Hall, B.A., Fenton-May, A.E., Vagin, A.A., Dejnirattisai, W., Felce, J.,
Mongkolsapaya, J., Palma, A.S., Liu, Y., Feizi, T., Screaton, G.R., Murshudov, G.N., O'Callaghan,
C.A. “Structural flexibility of the macrophage dengue virus receptor CLEC5A: implications for ligand
binding and signaling”. J Biol Chem. 286:24208-18, 2011.
9. Møllegaard, K.M., Duus, K., Træholt, S.D., Thaysen-Andersen, M., Liu, Y., Palma, A.S., Feizi, T.,
Hansen, P.R., Højrup, P., Houen, G. The interactions of calreticulin with immunoglobulin G and
immunoglobulin Y. Biochim Biophys Acta. 1814:889-99, 2011
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10. Palma, A.S., Liu, Y., Childs, R.A., Herbert, C., Wang, D, Chai, W, Feizi, T. “The human epithelial
carcinoma antigen recognized by monoclonal antibody AE3 is expressed on a sulfoglycolipid in
addition to neoplastic mucins” Biochem Biophys Res Commun. 408:548-52, 2011
11. Capodicasa, C., Chiani, P., Bromuro, C., De Bernardis, F., Catellani, M., Palma, A.S., Liu, Y., Feizi,
T., Cassone, A., Benvenuto, E., Torosantucci, A. “Plant production of anti-β-glucan antibodies for
immunotherapy of fungal infections in humans” Plant Biotechnol J 9:776-87, 2011
12. Neu, U., Maginnis, M.S., Palma, A.S., Stroeh, L.J., Nelson, C.D., Feizi,T., Atwood, W.J., Stehle, T..
Structure-function analysis of the human JC polyomavirus establishes the LSTc pentasaccharide as
a functional receptor motif. Cell Host & Microbe 8:309-19, 2010
Press release: http://news.brown.edu/pressreleases/2010/10/polyoma
13. Liu, Y., Childs, R.A., Matrosovich, T., Wharton, S., Palma, A.S., Chai, W., Daniels, R., Gregory, V.,
Uhlendorff, J., Kiso, M., Klenk, H.D., Hay, A., Feizi, T., Matrosovich, M. Altered receptor specificity
and cell tropism of D222G haemagglutinin mutants from fatal cases of pandemic A(H1N1) 2009
influenza. J Virol 84: 12069-74, 2010
14. Dunlop, D.C., Bonomelli, C., Mansab, F., Vasiljevic, S., Doores, K.J., Wormald, M.R., Palma,
A.S., Feizi, T., Harvey, D.J., Dwek, R.A., Crispin, M., Scanlan, C.N.Polysaccharide mimicry of the
epitope of the broadly neutralizing anti-HIV antibody, 2G12, induces enhanced antibody responses
to self oligomannose glycans. Glycobiology. 2010 Jul;20(7):812-23
15. Friedrich, N., Santos, J.M., Liu, Y., Palma, A.S., Leon, E., Saouros, S., Kiso, M., Blackman,
M.J., Matthews, S., Feizi, T., Soldati-Favre, D. “Members of a novel protein family containing MAR
domains act as sialic acid-binding lectins during host cell invasion by apicomplexan parasites”. J Biol
Chem 285:2064-76, 2010
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16. Palma, A.S . Childs R.A ., Wharton S., Matrosovich T., Liu Y., Chai W., Campanero-Rhodes M.A.,
Zhang Y., Eickmann M., Kiso M., Hay A., Matrosovich M., Feizi T. “Receptor-binding specificity of
pandemic influenza A (H1N1) 2009 virus determined by carbohydrate microarray” Nat Biotechnol.
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27:797-9, 2009 ( co-first authors).
Press release:
http://www3.imperial.ac.uk/newsandeventspggrp/imperialcollege/newssummary/news_10-9-200911-16-38
17. Torosantucci, A., Chiani, P., Bromuro, C., De Bernardis, F., Palma, A.S., Liu, Y., Mignogna, G.,
Maras, B., Colone, M., Stringaro, A., Zamboni, S., Feizi, T., Cassone, A. “Protection by anti-β-Glucan
Antibodies is associated with restricted β-1,3 glucan binding specificity and inhibition of fungal
growth and adherence” PLoS ONE 4, e5392, 2009.
18. Liu, Y., Palma, A.S., Feizi, T. “Carbohydrate microarrays: key developments in glycobiology” Biol
Chem 390, 647-56, 2009
19. Schallus, T., Jaeckh, C., Féeher, K., Palma, A.S., Liu, Y., Simpson, J.C., Mackeen, M., Stier, G.,
Gibson, T.J. Feizi, T., Pieler, T. and Muhle-Goll, C. “Malectin - a novel carbohydrate-binding protein
of the endoplasmic reticulum and a new player in the early steps of protein N-glycosylation” Mol Biol
Cell 19: 3404-3414, 2008.
20. Palma, A.S., de Carvalho, M., Grammel, N., Pinto, S., Barata, N., Conradt, H.S. and Costa, J.
“Proteomic analysis of plasma from Portuguese patients with familial amyotrophic lateral sclerosis”.
Amyotroph Lateral Scler Other Motor Neuron Disord, April 1:1-11, 2008.
21. Gomes, C., Palma, A.S., Almeida, R., Regalla, M., McCluskey, L.F., Trojanowski, J.Q. and Costa, J.
“Establishment of a cell model of ALS disease: Golgi apparatus disruption occurs independently from
apoptosis”. Biotechnol Lett 30: 603-10, 2008.
22. Palma, A.S., Feizi, T., Zhang, Y., Stoll, M.S., Lawson, A.M., Díaz-Rodríguez, E., CampaneroRhodes, M.A., Costa, J., Gordon, S., Brown, G.D. and Chai, W. “Ligands for the beta-glucan
receptor, dectin-1, assigned using ‘designer’ microarrays of oligosaccharide probes (neoglycolipids)
generated from glucan polysaccharides”. J Biol Chem 281: 5771-5779, 2006.
23. Palma, A.S., de Carvalho, M., Barata, N., Evangelista, T., Chicau, P., Regalla, M. and Costa, J.
“Biochemical characterisation of plasma in Amyotrophic Lateral Sclerosis: amino acid and protein
composition”. Amyotroph Lateral Scler Other Motor Neuron Disord 6: 104-110, 2005.
24. Palma, A.S., Morais, V.A., Coelho, A.V. and Costa, J. “Effect of the manganese ion on human α3/4
fucosyltransferase III activity”. Biometals 17: 35-43, 2004.
25. Palma, A.S., Vila-Verde, C., Pires, A.S., Fevereiro, P.S. and Costa, J. “A novel plant alpha 14fucosyltransferase (Vaccinium myrtillus L.) synthesises the Lewisa adhesion determinant”. FEBS
Lett 499: 235-8, 2001.
26. Sousa, V.L., Costa, M.T., Palma, A.S., Enguita, F. and Costa, J. “Localisation, purification and
specificity of the full-length membrane bound form of human recombinant α3/4 fucosyltransferase
from BHK-21B cells”. Biochem J 357: 803-810, 2001
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27. Morais, V.A., Serpa, J., Palma, A.S., Costa, M.T., Maranga, L. and Costa, J. “Expression and
characterisation of recombinant human alpha3/4-Fucosyltransferase III from Sf9 and Tn cells using
the baculovirus expression system”. Biochem J 353: 719-725, 2001.
CONFERENCE ABSTRACTS
1. Palma, A.S., Liu, Y., Zhang, Y., et al. Designer-oligosaccharide microarrays to decipher ligands in
mammalian and prokaryotic glucan-recognition systems Glycobiology 22: 11, 1612-1613, 2012
2. Watson, A. A., Lebedev, A. A., Hall, B. A.; et al. Structural flexibility and ligand-binding
characteristics of the macrophage dengue virus receptor CLEC5A Immunology 135: 101, 2011
3. Liu, Y., Palma, A.S., Chai, W., et al. “The latest on Malectin – A lectin of the Endoplasmic Reticulum”
Glycobiology 19: 11, 1301-1302, 2009
4. Palma, A.S., Liu, Y., Campanero-Rhodes, M.A et al. “Malectin-a novel lectin of the endoplasmic
reticulum and a candidate new player in the early steps of protein N-glycosylation” Glycobiology 18:
11, 948-949, 2008
COMMUNICATIONS IN SCIENTIFIC MEETINGS
ORAL COMMUNICATIONS BY INVITATION
1. “Ligand discovery of carbohydrate recognition systems: the role of glycan microarrays”. Invited
seminar of Systems Biology Program, Universidade de Aveiro, 3 May, 2013
2. “Insights into host glycan ‘receptors’ for human viruses: The role of glycan microarrays”. Invited
lecture at the II Post-Doc Symposium: Glycobiology and Disease, IPATIMUP, Oporto, 23 September
2011.
3. “Glycan microarrays”. Invited tutorial lecture at the Workshop entitled Glycans in Cell
Communication. What kind of Science is Glycoscience? Faculty of Medical Sciences, New University
of Lisbon, 24 September 2010.
4. “Studies of glucan-recognition systems with ‘designer’ oligosaccharide microarrays”, ESFEuroGlycoScience Forum Scientific Meeting, Lisbon, 2010
5. “Characterization of the epitope recognized by monoclonal antibodies PC-1 and PC-2 that bind to
human prostate cancers (Progress report)” Alliance of Glycobiologists for Detection of Cancer and
Cancer Risk, Mie, Japan, 2009.
6. "Studies of glucan-recognition systems with ‘designer’ oligosaccharide microarrays", FCT/UNL, 2008
7. “Oligosaccharide ligand(s) for the β-glucan receptor, Dectin-1, assigned by the neoglycolipid-based
oligosaccharide array technology”. Science Conferences at noon (SCAN), ITQB/UNL, Oeiras, 2005.
8. “Human α3/4- Fucosyltransferase III (Fuc-TIII) EC 2.4.1.65” Seminar organized by the Department of
Chemistry of University of Algarve, Faro, 2000.
AT INTERNATIONAL CONFERENCES SELECTED FROM ABSTRACTS
1. “Patterns of carbohydrate recognition by glucan-binding proteins: Observations using neoglycolipid (NGL)th
based microarrays”. 9 Carbohydrate Bioengineering Meeting (CBM9), Lisbon, Portugal, 2011.
2. “Malectin - a novel lectin of the endoplasmic reticulum and a candidate new player in the early steps of
protein N-glycosylation”. Annual Meeting of the Society for Glycobiology, Fort Worth, Texas, 2008.
3. “Studies of glucan-recognition systems with designer oligosaccharide microarrays”. Plant Polysaccharide
Workshop, Sigtuna, Sweden, 2008.
4. “Generation of oligosaccharide arrays by the neoglycolipid technology for the assignment of ligands for the
β-glucan receptor, Dectin-1”. Glupor 6-III Iberian Carbohydrate meeting, Coimbra, 2005.
POSTERS IN CONFERENCES
Recent contributions
1. “The Structural Basis of the Recognition of Di-glucosylated N-glycans by the ER Lectin Malectin”
Palma, A.S., Pinheiro, B., Liu, Y., Takeda, Y., Chai, W., Ito, Y., Romão, M.J., Carvalho, A.L., Feizi,
T. Annual Meeting of the Society for Glycobiology, Tampa, Florida, November 20-21, 2013
2. Designer-oligosaccharide microarrays to decipher ligands in mammalian and prokaryotic glucanrecognition systems” Palma, A.S., Liu, Y., Zhang, Y., et al. “Annual Meeting of the Society for
Glycobiology, San Diego, California, November 11-14, 2012.
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3. “Malectin: Crystal Structure Solved by MAD” Pinheiro, B.A., Carvalho, A.L., Romão, M.J., Palma,
st
A.S. 1 . Meeting of Synchrotron Radiation Users from Portugal, Faculdade de Ciências e
Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal, January 16, 2012.
4. “Observations on receptor-binding by influenza viruses using the neoglycolipid (NGL)-based
carbohydrate microarray system”. Palma, A,S., Liu, Y.,Childs, R.A., Chai, W., Wharton, S., Kiso, M.,
Matrosovich, T. Matrosovich, M., Hay, A., Feizi, T. Annual Meeting of the Society for Glycobiology,
Tampa, Florida, November 07-12, 2010.
5. “Malectin - a novel lectin of the endoplasmic reticulum and a candidate new player in the early steps
of protein N-glycosylation”, Palma, A.S., Liu, Y., Campanero-Rhodes, M.A., Childs, R.A., Stoll, M.S.,
Schallus, T., Muhle-Goll, C. Mackeen, M., Chai, W., Feizi, T. Annual Meeting of the Society for
Glycobiology, Fort Worth, Texas, November 12-15, 2008.
6. “Studies of patterns of carbohydrate recognition by glucan binding proteins using NGL-based
‘designer’ microarrays”, Palma, A.S., Liu, Y., Zhang, Y., Campanero-Rhodes, M.A., Childs, R.A.,
Stoll, M.S., Brown, G.D., Boraston, A.B., Flint, J.,. Gilbert, H., Fontes, C.M.G.A., Chai, W., Feizi T.
Royal Society of Chemistry Carbohydrate Group, Carbohydrate Arrays-Synthesis and Applications,
Manchester, UK, October 16-17, 2007.
7. “Microarray analysis of glucan-binding proteins”, Palma A.S., Chai W., Liu, Y., Campanero-Rhodes,
M.A., Childs, R.A., Stoll, M.S., Zhang, Y., Brown, G.D., Flint, J., Gilbert, H., Fontes, C.M.G.A.,
th
Boraston A.B., Feizi T. 7 International meeting of the Portuguese carbohydrate group-Glupor 7,
ITQB/UNL, September 12-15, 2007.
Past contributions
8. “Oligosaccharide ligands for the beta-Glucan receptor, Dectin-1, assigned by the neoglycolipidbased microarray technology”, Palma, A.S.; Feizi, T., Díaz-Rodríguez, E., Campanero-Rhodes, M.
A., Costa, J., Brown, G., Chai, W. XVIII International Symposium on Glycoconjugates,Glyco XVIII,
Florence, Italy, 2005.
9. “Study of the proteome and glycome from serum and cerebrospinal fluid of Amyotrophic Lateral
Sclerosis patients”, Palma A.S., de Carvalho M., Evangelista, T., Costa, J. 14th International
Symposium on ALS/MND, Milan, Italy, 2003.
10. “Specificity and divalent cation requirement of human alpha3/4 fucosyltransferase III”, Palma, A. S.,
Morais, V. A., Costa, J., II Iberian Carbohydrate Meeting, Ronda (Málaga), Spain, 2002.
11. “Specificity and oligomerization of human alpha3/4 fucosyltransferase III in BHK transfected cells”,
Sousa, V.L., Costa, M. T., Palma, A. S., Costa, J., 11th European Carbohydrate Symposium,
Lisbon, Portugal, 2001
12. “Localization, organization and specificity of human alpha3/4 fucosyltransferase III”, Sousa, V.L.,
Costa, M. T., Palma, A.S., Lanoix, J., Nilsson, T., Brito, A. C., Costa, J., 27th FEBS Meeting, Lisbon,
Portugal, 2001
13. “Human alpha3/4-fucosyltransferase III: specificity and cation divalent requirement. Implications in
the mechanism of catalysis”, Palma, A.S., Morais, V. A., Costa, J., 27th FEBS Meeting, Lisbon,
Portugal, 2001
14. “Specificity and divalent cation requirement of human alpha3/4-fucosyltransferase III”, Palma, A.S.,
Morais, V. A., Costa, J., 11th European Carbohydrate Symposium, Lisbon, Portugal, 2001.
15. “Human alpha3/4-fucosyltransferase III: specificity and cation divalent requirement. Implications in
the mechanism of catalysis”, Palma, A.S., Morais, V. A., Costa, J, YSF, Lisbon, Portugal, 2001.
SCIENTIFIC COLLABORATORS
Prof. Ten Feizi and Drs. Wengang Chai and Yan Liu (Imperial College London) on carbohydrate
microarrays; Prof. Harry Gilbert (University of Newcastle, UK) and Dr. Alisdair Boraston (University of
Victoria, Canada) on microbial CBMs; Prof Antonio Cassone (ISS, Italy) on anti-fungal antibodies; Dr. Thilo
Stehle (University of Tubingen, Germany) on human polyoma viruses; Prof. Angela Groenenborn (University
of Pittsburgh, USA) on microbial lectins with anti-HIV activities; Dr. Claudia Muhle Goll (KIT, Germany) and
Prof. Yukishige Ito (RIKEN, Japan) on malectin; Prof. Carlos Fontes (FMV/UTL), Prof. Maria João Romão,
Drs Ana Luísa Carvalho and Benedita Pinheiro (REQUIMTE, FCT/UNL) on specificities of microbial CBMs
and glycoside hydrolases; Prof. Manuel Coimbra (Universidade de Aveiro) on plant polysaccharides and
microarrays from cell surface glycans of the pathogen Helicobacter pylori; Dr Celso Reis (IPATIMUP,
Universidade do Porto) to identify novel H. pylori-carbohydrate interactions.
January, 2014
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