Curriculum Vitae - Universidade de Coimbra
Transcrição
Curriculum Vitae - Universidade de Coimbra
Curriculum Vitæ Paula Isabel da Silva Moreira Fevereiro de 2008 Nome: Paula Isabel da Silva Moreira Local e data de Nascimento: França; 4 de Janeiro de 1975 Nacionalidade: Portuguesa Morada Institucional: Instituto de Fisiologia da Faculdade de Medicina Centro de Neurociências e Biologia Celular Universidade de Coimbra 3000-345 Coimbra Portugal Telefone: (351) 239480012 Fax: (351) 239480034 Email: [email protected] / [email protected] Graus académicos, Instituições, áreas de estudo 2007 - Doutoramento em Ciências Biomédicas, Faculdade de Medicina, Universidade de Coimbra, Portugal 2002 - Mestrado em Biologia Celular, Faculdade de Ciências e Tecnologia, Universidade de Coimbra, Portugal 1998 - Licenciatura em Biologia (Ramo Científico), Faculdade de Ciências e Tecnologia, Universidade de Coimbra, Portugal Cargo actual, Instituição, data de início 2005 - presente - Assistente da Faculdade de Medicina, Universidade de Coimbra, Portugal Cargos anteriores 2002 - 2006 – Bolseira de Doutoramento da Fundação para a Ciência e a Tecnologia (SFRH/BD/5320/2001) 2000 - 2002 - Bolseira de Mestrado da Fundação para a Ciência e a Tecnologia (PRAXIS XXI/BM/20952/1999) 1998 - 2000 – Bolseira Técnica de Investigação da Fundação para a Ciência e a Tecnologia (PRAXIS XXI/BTI/16713/1998) Principal área científica de investigação: Neurociências (Neuroquímica): Estudo da bioenergética mitocondrial e do stresse oxidativo na doença de Alzheimer e na diabetes. O papel do envelhecimento, importante factor de risco, é também estudado. Outras áreas científicas de interesse: Bioquímica Clínica, Farmacologia, Neurologia, Toxicologia II Equipas editoriais de que faz parte Editora Associada da revista científica Journal of Alzheimer’s Disease (JAD) Editora Associada da revista científica Mini-Reviews in Medicinal Chemistry (MRMC) Sociedades de que é membro European Association for the Study of Diabetes Neuroscience Society Sociedade Portuguesa de Bioquímica Sociedade Portuguesa de Neurociências Prémios / Subsídios / Bolsas 2007 – Subsídio para participação em congresso internacional, Fundo de Apoio à Comunidade Científica (FACC), Fundação para a Ciência e a Tecnologia (FCT) 2006 / 2002 / 2000 – Subsídio para participação em congressos internacionais, Fundação Calouste Gulbenkian 2004 – Bolsa de estágio no estrangeiro, Fundação Luso-Americana (FLAD) 2004 / 2002 / 2000 - Subsídio para participação em congressos nacionais, Sociedade Portuguesa de Bioquímica (SPB) 2002 - 2006 – Bolsa de Doutoramento da Fundação para a Ciência e a Tecnologia (FCT) (SFRH/BD/5320/2001) 2003 – Prémio Estímulo à Investigação, Fundação Calouste Gulbenkian 2003 – Prémio de melhor comunicação em forma de poster, Physiological Society Spring workshop, The Physiological Society 2000 - 2002 - Bolsa de Mestrado da Fundação para a Ciência e a Tecnologia (FCT) (PRAXIS XXI/BM/20952/1999) 2001 / 2000 - Subsídio para participação em cursos avançados, Federation of the Societies of Biochemistry and Molecular Biology (FEBS) 1998 - 2000 – Bolsa Técnica de Investigação da Fundação para a Ciência e a Tecnologia (FCT) (PRAXIS XXI/BTI/16713/1998) Projectos de investigação 2007 - 2009 - European Foundation for the Study of Diabetes and Servier; Exploring the crosstalk between mitochondrial reactive oxygen species and the transcriptional factor hypoxia factor-1 in brain and retinal endothelium. Investigador Principal (100.000,00 €). 2004 - 2005 - Fundação Calouste Gulbenkian; Diabetes, doença de Alzheimer e mitocôndria: peças do mesmo puzzle? Investigador principal (15.000,00 €). 2001 – 2004 – Fundação para a Ciência e a Tecnologia; Mitochondria and diabetes: mitochondrial function in brain and heart in rat models for type 2 (non-insulin-dependent diabetes mellitus) Goto-Kakizaki. (Ref.: POCTI/ESP/43642/1999) Elemento da equipa de investigação; 50% de dedicação ao projecto (40.000,00 €). III 2001 – 2004 - Fundação para a Ciência e a Tecnologia; A comparative study of the neurotoxic mechanisms of prion and amyloid beta-peptides. Potential neuroprotective strategies” (Ref.: POCTI/NSE/36101/1999) Elemento da equipa de investigação; 60% de dedicação ao projecto (125.700,00 €). Avaliação de projectos de investigação European Commission - 7th Framework Programme for Research, Technological Development and Demonstration (Collaborative Projects) FP7-HEALTH-2007 Avaliação de artigos submetidos a revistas científicas internacionais Biochemical Pharmacology, Journal of Alzheimer’s Disease, Journal of Biological Chemistry, Journal of Pharmacology and Experimental Therapeutics, Life Sciences, Neurobiology of Disease, Toxicology and Applied Pharmacology Organização de reuniões científicas internacionais “80th Annual Meeting of the American Association of Neuropathologists” (Cleveland, Ohio, USA, 24 a 27 de Junho de 2004). Organização de cursos avançados “Neurodegenerative disorders” (Centro de Neurociências e Biologia Celular, Coimbra, Portugal, 28 de Janeiro a 1 de Fevereiro de 2008). “Bioenergética mitocondrial: proteínas desacopladoras e aplicações em toxicologia experimental” (Universidade de Coimbra, Coimbra, Portugal, 26 a 31 de Maio de 2003). Participação em cursos avançados e workshops 2005 - “Mitochondria: Between Life and Death – International Courses on Toxicology” (Centro de Neurociências e Biologia Celular, Universidade Coimbra, Coimbra, Portugal, 27 a 29 de Abril) 2004 - “Biologia da Morte Celular II: Regulação da Apoptose” (Faculdade de Farmcia, Universidade de Lisboa, Lisboa, Portugal, 12 a 16 de Janeiro) 2003 - “The physiological society spring workshop 2003” (Budapeste, Hungria, 3 a 5 de Abril) 2002 - i) “Hormone-dependent organisation of the brain” (Braga, Portugal, 30 de Setembro a 4 de Outubro) ii) “Novel Therapeutic Opportunities in Neurodegenerative Diseases” (Aveiro, Portugal, 12 a 13 de Setembro) 2001 - i) “Stereotaxic Surgery for Rodent Models of Neurodegeneration and Repair” (Coimbra, Portugal, 15 a 19 de Outubro) ii) Advanced FEBS Course “Mitochondria in the cell life and death” (Moscovo, Rússia, 2 a 7 de Setembro) iii) “A Practical Course on Identification of Apoptosis: Mitochondrial Pathway” (Faculdade de Farmácia, Universidade de Lisboa, Lisboa, Portugal, 9 a 13 de Julho) iv) “Oxidative Stress: From Basic Science to Medicine” (Centro de Neurociências e Biologia Celular de Coimbra, Coimbra, Portugal, 18 a 20 de Junho) v) “Mechanisms of Mitochondrial Toxicity” (Centro de Neurociências e Biologia Celular de Coimbra, Coimbra, Portugal, 21 a 23 de Maio) IV 2000 - i) Workshop "Cell Death" (IBMC-Porto, Portugal, 10 a 11 de Junho) ii) FEBS Advanced Course 2000-03 “Expression and regulation of mitochondrial oxidative phosphorylation and disorders in human pathology” (Martina Franca, Itália, 5 a 10 de Março) 1999 - i) “Curso Avançado em Bioenergética Mitocondrial: Investigação Fundamental e Uso em Toxicologia Experimental” (Coimbra, Portugal, 12 a 23 de Julho) Orientação: Doutoramento em Biologia Celular da Faculdade de Ciências e Tecnologia, Universidade de Coimbra 2008-2011: Sónia Catarina de Sousa Correia (Role of mitochondria in the regulation of factor hypoxiainducible factor-1 in brain endothelium under diabetic conditions) (Co-orientação da Drª Maria Sancha Santos) Mestrado em Biologia Celular da Faculdade de Ciências e Tecnologia, Universidade de Coimbra 2007-2008: Cristina Isabel Marques Maurício de Carvalho (Efeito da metformina na bioenergética mitocondrial e no stresse oxidativo). Estágios de licenciatura em Biologia (Ramo Científico) da Faculdade de Ciências e Tecnologia, Universidade de Coimbra 2007-2008: Renato Xavier Coelho Santos (Efeito da atorvastatina no cérebro de ratos diabéticos) Sandrina Silva (Efeito da dieta gorda no cérebro de ratos diabéticos Goto-kakizaki) Susana Maria Batista Tieres Tomé Cardoso (Efeito da metformina no cérebro de ratos diabéticos) 2006-2007: Sónia Catarina de Sousa Correia (Efeito da metformina nos transportadores de glicose de cérebros de ratos diabéticos) Cristina Isabel Marques Maurício de Carvalho (Efeito da metformina em mitocôndrias isoladas de fígado de rato). Publicações - Artigos Originais 24- Carvalho C, Correia S, Santos MS, Seiça R, Oliveira CR, Moreira PI. Metformin promotes isolated rat liver mitochondria impairment. Mol.Cell Biochem. 2008;308:75-83. 23- Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, Baba M, Baehrecke EH, Bahr BA, Ballabio A, Bamber BA, Bassham DC, Bergamini E, Bi X, BiardPiechaczyk M, Blum JS, Bredesen DE, Brodsky JL, Brumell JH, Brunk UT, Bursch W, Camougrand N, Cebollero E, Cecconi F, Chen Y, Chin LS, Choi A, Chu CT, Chung J, Clarke PG, Clark RS, Clarke SG, Clavé C, Cleveland JL, Codogno P, Colombo MI, Coto-Montes A, Cregg JM, Cuervo AM, Debnath J, Demarchi F, Dennis PB, Dennis PA, Deretic V, Devenish RJ, Di Sano F, Dice JF, Difiglia M, Dinesh-Kumar S, Distelhorst CW, Djavaheri-Mergny M, Dorsey FC, Dröge W, Dron M, Dunn WA Jr, Duszenko M, Eissa NT, Elazar Z, Esclatine A, Eskelinen EL, Fésüs L, Finley KD, Fuentes JM, Fueyo J, Fujisaki K, Galliot B, Gao FB, Gewirtz DA, Gibson SB, Gohla A, Goldberg AL, Gonzalez R, González-Estévez C, Gorski S, V Gottlieb RA, Häussinger D, He YW, Heidenreich K, Hill JA, Høyer-Hansen M, Hu X, Huang WP, Iwasaki A, Jäättelä M, Jackson WT, Jiang X, Jin S, Johansen T, Jung JU, Kadowaki M, Kang C, Kelekar A, Kessel DH, Kiel JA, Kim HP, Kimchi A, Kinsella TJ, Kiselyov K, Kitamoto K, Knecht E, Komatsu M, Kominami E, Kondo S, Kovács AL, Kroemer G, Kuan CY, Kumar R, Kundu M, Landry J, Laporte M, Le W, Lei HY, Lenardo MJ, Levine B, Lieberman A, Lim KL, Lin FC, Liou W, Liu LF, Lopez-Berestein G, López-Otín C, Lu B, Macleod KF, Malorni W, Martinet W, Matsuoka K, Mautner J, Meijer AJ, Meléndez A, Michels P, Miotto G, Mistiaen WP, Mizushima N, Mograbi B, Monastyrska I, Moore MN, Moreira PI, Moriyasu Y, Motyl T, Münz C, Murphy LO, Naqvi NI, Neufeld TP, Nishino I, Nixon RA, Noda T, Nürnberg B, Ogawa M, Oleinick NL, Olsen LJ, Ozpolat B, Paglin S, Palmer GE, Papassideri I, Parkes M, Perlmutter DH, Perry G, Piacentini M, Pinkas-Kramarski R, Prescott M, Proikas-Cezanne T, Raben N, Rami A, Reggiori F, Rohrer B, Rubinsztein DC, Ryan KM, Sadoshima J, Sakagami H, Sakai Y, Sandri M, Sasakawa C, Sass M, Schneider C, Seglen PO, Seleverstov O, Settleman J, Shacka JJ, Shapiro IM, Sibirny A, Silva-Zacarin EC, Simon HU, Simone C, Simonsen A, Smith MA, Spanel-Borowski K, Srinivas V, Steeves M, Stenmark H, Stromhaug PE, Subauste CS, Sugimoto S, Sulzer D, Suzuki T, Swanson MS, Tabas I, Takeshita F, Talbot NJ, Tallóczy Z, Tanaka K, Tanaka K, Tanida I, Taylor GS, Taylor JP, Terman A, Tettamanti G, Thompson CB, Thumm M, Tolkovsky AM, Tooze SA, Truant R, Tumanovska LV, Uchiyama Y, Ueno T, Uzcátegui NL, van der Klei I, Vaquero EC, Vellai T, Vogel MW, Wang HG, Webster P, Wiley JW, Xi Z, Xiao G, Yahalom J, Yang JM, Yap G, Yin XM, Yoshimori T, Yu L, Yue Z, Yuzaki M, Zabirnyk O, Zheng X, Zhu X, Deter RL. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 2007; 4:151-175. 22- Moreira PI, Harris PLR, Zhu X, Santos MS, Oliveira CR, Smith MA, Perry G. Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts. J. Alzheimer Dis. 2007;12:195-206. 21- Moreira PI, Siedlak SL, Wang X, Santos MS, Oliveira CR, Tabaton M, Nunomura A, Szweda LI, Aliev G, Smith MA, Zhu X, Perry G. Autophagocytosis of mitochondria is prominent in Alzheimer disease. J. Neuropathol. Exp. Neurol. 2007;66:525-532. 20- Moreira PI, Custódio J, Nunes E, Moreno A, Seiça R, Oliveira CR, Santos MS. Estradiol affects liver mitochondrial function in ovariectomized and tamoxifen-treated ovariectomized female rats. Toxicol. Appl. Pharmacol. 2007;221:102-110. 19- Nunes E, Peixoto F, Louro T, Sena CM, Santos MS, Matafome P, Moreira PI, Seiça R. Soybean oil treatment impairs glucose-stimulated insulin secretion and changes fatty acid composition of normal and diabetic islets. Acta Diabetol. 2007;44:121-130. 18- Moreira PI, Custódio J, Moreno A, Oliveira CR, Santos MS. Tamoxifen and estradiol interact with the flavin mononucleotide site of complex I leading to mitochondrial failure. J. Biol Chem. 2006;281:10143-10152. 17- Moreira PI, Rolo AP, Sena C, Seiça R, Oliveira CR, Santos MS. Insulin attenuates diabetes-related mitochondrial alterations: a comparative study. Med. Chem. 2006;2:299-308. 16- Moreira PI, Santos MS, Sena C, Nunes E, Seiça R, Oliveira CR. CoQ10 therapy attenuates amyloid β-peptide toxicity in brain mitochondria isolated from aged diabetic rats. Exp. Neurol. 2005;196:112-9. 15- Moreira PI, Santos MS, Sena C, Seiça R, Oliveira CR. Insulin protects against amyloid beta-peptide toxicity in brain mitochondria of diabetic rats. Neurobiol. Dis. 2005;18:628-37. VI 14- Moreira PI, Custodio JB, Oliveira CR, Santos MS. Brain mitochondrial injury induced by xidative stress-related events is prevented by tamoxifen. Neuropharmacology 2005;48:435-47. 13- Petersen RB, Siedlak SL, Lee HG, Kim YS, Nunomura A, Tagliavini F, Ghetti B, Cras P, Moreira PI, Castellani RJ, Guentchev M, Budka H, Ironside JW, Gambetti P, Smith MA, Perry G. Redox metals and oxidative abnormalities in human prion diseases. Acta Neuropathol. 2005;110:232-8. 12- Webber KM, Smith MA, Lee HG, Harris PL, Moreira P, Perry G, Zhu X. Mitogen- and stress-activated protein kinase 1: convergence of the ERK and p38 pathways in Alzheimer's disease. J Neurosci. Res. 2005;79:554-60. 11- Honda K, Smith MA, Zhu X, Baus D, Merrick WC, Tartakoff AM, Hattier T, Harris PL, Siedlak SL, Fujioka H, Liu Q, Moreira PI, Miller FP, Nunomura A, Shimohama S, Perry G. Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron. J. Biol. Chem. 2005; 280:20978-86. 10- Liu Q, Smith MA, Avila J, DeBernardis J, Kansal M, Takeda A, Zhu X, Nunomura A, Honda K, Moreira PI, Oliveira CR, Santos MS, Shimohama S, Aliev G, de la Torre J, Ghanbari HA, Siedlak SL, Harris PL, Sayre LM, Perry G. Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations. Free Radic. Biol. Med. 2005;38:746-54. 9- Baykal A, Sarigül F, Süleymanlar G, Moreira PI, Perry G, Smith MA, Alicigüzel Y. Ciprofloxacin does not exert nephrotoxicity in rats. Am. J. Infectious Dis. 2005;1:145-148. 8- Moreira PI, Custodio JB, Oliveira CR, Santos MS. Hydroxytamoxifen protects against oxidative stress in brain mitochondria. Biochem Pharmacol. 2004;68:195-204. 7- Moreira PI, Santos MS, Moreno AM, Proenca T, Seica R, Oliveira CR. Effect of streptozotocin-induced diabetes on rat brain mitochondria. J Neuroendocrinol. 2004;16:32-8. 6- Moreira PI, Santos MS, Moreno AM, Seica R, Oliveira CR. Increased vulnerability of brain mitochondria in diabetic (Goto-Kakizaki) rats with aging and amyloid-beta exposure. Diabetes. 2003;52:1449-56. 5- Moreira PI, Santos MS, Moreno A, Rego AC, Oliveira C. Effect of amyloid beta-peptide on permeability transition pore: a comparative study. J Neurosci Res. 2002;69:257-67. 4- Moreira PI, Santos MS, Moreno A, Oliveira C. Amyloid beta-peptide promotes permeability transition pore in brain mitochondria. Biosci Rep. 2001;21:789-800. 3- Moreira P, Pereira C, Santos MS, Oliveira C. Effect of zinc ions on the cytotoxicity induced by the amyloid beta-peptide. Antioxid Redox Signal. 2000;2:317-25. 2- Pereira C, Moreira P, Seiça R, Santos MS, Oliveira CR. Susceptibility to beta-amyloidinduced toxicity is decreased in goto-kakizaki diabetic rats: involvement of oxidative stress. Exp Neurol. 2000;161:383-91. 1- Santos MS, Duarte AI, Moreira PI, Oliveira CR. Synaptosomal response to oxidative stress: effect of vinpocetine. Free Radic Res. 2000;32:57-66. VII Publicações - Artigos de Revisão 45- Moreira PI, Nunomura A, Nakamura M, Takeda A, Shenk JC, Aliev G, Smith MA, Perry G. Nucleic acid oxidation in Alzheimer disease. Free Radic. Biol. Med. 2008; in press 44- Moreira PI, Santos MS, Oliveira CR, Shenk JC, Nunomura A, Smith MA, Zhu X, Perry G. Alzheimer disease and the role of free radicals in the pathogenesis of the disease. CNS Neurol. Disord. Drug Targets 2008;7:3-10. 43- Nunomura A, Moreira PI, Lee HG, Zhu X, Castellani RJ Smith MA, Perry G. Neuronal death and survival under oxidative stress in Alzheimer and Parkinson diseases. CNS Neurol. Disord. Drug Targets 2007;6:411-423. 42- Nunomura A, Moreira PI, Takeda A, Smith MA, Perry G. Oxidative RNA damage and neurodegeneration. Curr. Med. Chem. 2007;14:2968-2975. 41- Moreira PI, Siedlak SL, Wang X, Santos MS, Oliveira CR, Tabaton M, Nunomura A, Szweda LI, Aliev G, Smith MA, Zhu X, Perry G. Increased Autophagic Degradation of Mitochondria in Alzheimer Disease. Autophagy 2007;3:614-615. 40- Moreira PI, Santos MS, Oliveira CR. Alzheimer disease: a lesson from mitochondrial dysfunction. Antioxid. Redox Signal. 2007;9:1621-1630. 39- Castellani RJ, Moreira PI, Liu G, Dobson J, Perry G, Smith MA, Zhu X. Iron: The Redoxactive Center of Oxidative Stress in Alzheimer Disease. Neurochem. Res. 2007;32:1640-5. 38- Moreira PI, Santos MS, Seiça R, Oliveira CR. Brain mitochondrial dysfunction as a link between Alzheimer's disease and diabetes. J. Neurol. Sci. 2007;257:206-14. 37- Castellani RJ, Zhu X, Lee HG, Moreira PI, Perry G, Smith MA. Neuropathology and treatment of Alzheimer disease: did we lose the forest for the trees? Expert Rev. Neurother. 2007;7:473-85. 36- Casadeus G, Moreira PI, Nunomura A, Siedlak SL, Bligh-Glover W, Balraj E, Petot G, Smith MA, Perry G. Indices of metabolic dysfunction and oxidative stress. Neurochem. Res. 2007;32:717-22. 35- Zhu X, Smith MA, Honda K, Aliev G, Moreira PI, Nunomura A, Casadeus G, Harris PL, Siedlak SL, Perry G. Vascular oxidative stress in Alzheimer disease. J. Neurol. Sci. 2007;257:240-6. 34- Liu Q, Xie F, Rolston R, Moreira PI, Nunomura A, Zhu X, Smith MA, Perry G. Prevention and treatment of Alzheimer disease and aging: antioxidants. Mini Rev. Med. Chem. 2007;7:17180. 33- Moreira PI, Cardoso SM, Santos MS, Oliveira CR. The key role of mitochondria in Alzheimer’s disease. J. Alzheimers Dis. 2006;9:101-110. VIII 32- Moreira PI, Oliveira C. Foreword: Mitochondria in Alzheimer disease. J. Alzheimers Dis. 2006;9:99. 31- Moreira PI, Zhu X, Nunomura A, Smith MA, Perry G. Therapeutic options in Alzheimer’s disease. Expert Rev. Neurother. 2006;6:897-910. 30- Moreira PI, Zhu X, Lee H, Nunomura A, Smith MA, Perry G. Therapeutical potential of oxidative stress reduction in Alzheimer’s disease. Future Neurol. 2006;1:1-4. 29- Moreira PI, Zhu X, Liu Q, Honda K, Siedlak SL, Harris PL, Smith MA, Perry G. Compensatory responses induced by oxidative stress in Alzheimer disease. Biol. Res. 2006;39:7-13. 28- Moreira PI, Zhu X, Lee H, Honda K, Smith MA, Perry G. The (un)balance between metabolic and oxidative abnormalities and cellular compensatory responses in Alzheimer’s disease. Mech. Ageing Dev. 2006;127:501-506. 27- Moreira PI, Honda K, Zhu X, Nunomura A, Casadesus G, Smith MA, Perry G. Brain and brawn: parallels in oxidative stress. Neurology 2006;66:S97-101. 26- Zhu X, Perry G, Moreira PI, Aliev G, Cash AD, Hirai K, Smith MA. Mitochondrial abnormalities and oxidative imbalance in Alzheimer disease. J. Alzheimer’s Dis. 2006;9:147153. 25- Nunomura A, Cstellani RJ, Zhu X, Moreira PI, Perry G, Smith MA. Involvement of oxidative stress in Alzheimer disease. J. Neuropathl. Exp. Neurol. 2006;65:631-641. 24- Nunomura A, Cstellani RJ, Lee HG, Moreira PI, Zhu X, Perry G, Smith MA. Neuropathology in Alzheimer’s disease: awaking from a hundred-year-old dream. Sci. Aging Knowledge Environ. 2006;3:pe10. 23- Zhu X, Lee HG, Moreira PI, Smith MA, Perry G. Presenilin mutation: a deadly first hit in Alzheimer disease. A commentary on “aging sensitizes towards ROS formation and lipid peroxidation in PS1M146L transgenic mice”. Free Radic. Biol. Med. 2006;40:737-379. 22- Franco S, Blasco M, Siedlak SL, Harris PLR, Moreira PI, Perry G, Smith MA. Telomeres and telomerase in Alzheimer’s disease: epiphenomena or a new focus for therapeutic strategy? Alzheimer’s & Dementia 2:164-168, 2006. 21- Moreira PI, Honda K, Liu Q, Santos MS, Oliveira CR, Aliev G, Nunomura A, Zhu X, Smith MA, Perry G. Oxidative stress: the old enemy in Alzheimer's disease pathophysiology. Curr. Alzheimer Res. 2005;2:403-8. 20- Moreira PI, Honda K, Liu Q, Aliev G, Oliveira CR, Santos MS, Zhu X, Smith MA, Perry G. Alzheimer’s disease and oxidative stress: the old problem remains unsolved. Curr. Med. Chem.– Central Nervous System Agents 2005;5:51-62. 19- Moreira PI, Oliveira CR, Santos MS, Nunomura A, Honda K, Zhu X, Smith MA, Perry G. A second look into oxidant mechanisms in Alzheimer’s disease. Curr. Neurovasc. Res. 2005;2:179-184. 18- Moreira PI, Smith MA, Zhu X, Honda K, Lee HG, Aliev G, Perry G. Oxidative damage and Alzheimer's disease: are antioxidant therapies useful? Drug News Perspect. 2005;18:13-9. IX 17- Moreira PI, Siedlak SL, Aliev G, Zhu X, Cash AD, Smith MA, Perry G. Oxidative stress mechanisms and potential therapeutics in Alzheimer disease. J Neural Transm. 2005;112:92132. 16- Moreira PI, Smith MA, Zhu X, Nunomura A, Castellani RJ, Perry G. Oxidative stress and neurodegeneration. Ann. N.Y. Acad. Sci. 2005;1043:545-52. 15- Sayre LM, Moreira PI, Smith MA, Perry G. Metal ions and oxidative protein modification in neurological disease. Ann Ist Super Sanita. 2005;41:143-164. 14- Cardoso SM, Moreira PI, Agostinho P, Pereira C, Oliveira CR. Neurodegenerative pathways in Parkinson’s disease: therapeutical strategies. Curr. Drug Target – CNS & Neurol. Disord. 2005;4:405-19. 13- Pereira C, Agostinho P, Moreira PI, Cardoso SM, Oliveira CR. Alzheimer’s diseaseassociated neurotoxic mechanisms and neuroprotective strategies. Curr Drug Target – CNS & Neurol. Disord. 2005;4:383-403. 12- Honda K, Moreira PI, Liu Q, Siedlak SL, Zhu X, Smith MA, Perry G. Redox active iron at the center of oxidative stress in Alzheimer disease. Lett. Drug Design Discovery 2005;2:479-82. 11- Zhu X, Moreira PI, Smith MA, Perry G. Alzheimer Disease: an intracellular movement disorder? Trends Mol. Med. 2005;11:391-3 10- Marlatt MW, Webber KM, Moreira PI, Lee HG, Casadesus G, Honda K, Zhu X, Perry G, Smith MA. Therapeutic Opportunities in Alzheimer Disease: One for all or all for One? Curr. Med. Chem. 2005;12:1137-47. 9- Lee HG, Perry G, Moreira PI, Garrett MR, Liu Q, Zhu X, Takeda A, Nunomura A, Smith MA. Tau phosphorylation in Alzheimer's disease: pathogen or protector? Trends Mol. Med. 2005;11:164-9. 8- Smith MA, Nunomura A, Lee HG, Zhu X, Moreira PI, Avila J, Perry G. Chronological primacy of oxidative stress in Alzheimer disease. Neurobiol. Aging. 2005;26:579-80; discussion 587-95. 7- Moreira PI, Smith MA, Zhu X, Santos MS, Oliveira CR, Perry G. Therapeutic potential of oxidant mechanisms in Alzheimer's disease. Expert Rev Neurother. 2004;4:995-1004. 6- Moreira PI, Perry G. Mitochondria and Alzheimer’s disease: a powerful link. United Mitochondrial Research Foundation: Mitochondrial News 2004;9:8-15. 5- Moreira PI, Oliveira CR, Santos MS, Honda K, Liu Q, Smith MA, Zhu X, Perry G. Alzheimer disease: oxidative stress and homeostatic regulation. Rev Fac Med Lisboa. 2004;9:455-60. 4- Moreira PI, Liu Q, Honda K, Smith MA, Santos MS, Oliveira CR. Is intraneuronal amyloid beta-peptide accumulation the trigger of Alzheimer's disease pathophysiology? J Alzheimers Dis. 2004;6:433-4; discussion 443-9. 3- Liu Q, Xie F, Siedlak SL, Nunomura A, Honda K, Moreira PI, Zhu X, Smith MA, Perry G. Neurofilament proteins in neurodegenerative diseases. Cell Mol Life Sci. 2004;61:3057-75. 2- Lee HG, Moreira PI, Zhu X, Smith MA, Perry G. Staying connected: synapses in Alzheimer disease. Am J Pathol. 2004;165:1461-4. X 1- Pereira CA, Agostinho P, Moreira PI, Duarte AI, Santos MS, Oliveira CR. Neuroprotection strategies: Effect of Vinpocetine in vitro Oxidative Stress Models. Acta Med Port. 2003;16:401406. Publicações On-line 6- Casadesus G, Lee HG, Moreira P, Nunomura A, Perry G, Smith MA, Zhu X. Comment: Neurofibrillary tangles: villain or merely vilified? What’s next? TADDLs/TAuDDLs! Alzheimer Research Forum, 2005, http://www.alzforum.org/new/detail.asp?id=1227. 5- Aliev G, Moreira P, Obrenovich M, Oliveira C, Perry G, Smith M. Comment: Mitochondria: Another Dimension in Protein Misfolding. Alzheimer Research Forum 2005, http://www.alzforum.org/pap/annotation.asp?powID=43769. 4- Moreira PI, Oliveira CR, Santos MS, Smith MA, Perry G. Comment: Brain aging and age-related neurodegenerative diseases: are vitamin and traceelement supplementation the “miraculous” solution? Alzheimer Research Forum, 2004, http://www.alzforum.org/pap/annotation.asp?powID=593. 3- Moreira PI, Aliev G, Oliveira C, Perry G, Santos MS, Smith MA. Comment: The new/old good/bad guy in Alzheimer’s disease. Alzheimer Research Forum 2004, http://www.alzforum.org/new/detail.asp?id=1000. 2- Honda K, Liu Q, Moreira PI, Perry G, Smith MA. Comment: Embalming amyloid-ß: the role for aldehyde stress in Alzheimer disease. Alzheimer Research Forum 2004, http://www.alzforum.org/pap/annotation.asp?powID=35429. 1- Honda K, Liu Q, Moreira PI, Perry G, Smith M, Zhu X. Comment: Parkin and mitochondria: are they allies in the war against Parkinson’s disease? Alzheimer Research Forum 2004, http://www.alzforum.org/pap/annotation.asp?powID=35242. Capítulos de livros 16- Moreira PI, Smith MA, Zhu X, Nunomura A, Perry G. (2007) The potential application of antioxidant agents in Alzheimer disease therapeutics. In Pharmacological Mechanisms in Alzheimer’s Therapeutics, Cuello AC, Ed. Springer, New York, in press. 15- Moreira PI, Zhu X, Smith MA, Perry G. (2007) Alzheimer’s disease overview. In The New Encyclopedia of Neuroscience, Squire LR, Ed. Elsevier, Oxford, in press. 14- Liu Q, Xie F, Smith MA, Moreira PI, Zhu X, Perry G. Current progress in neurofilamentopathy in neurodegenerative diseases. In: New Research in Neurofilament Proteins, Columbus F, Ed, Nova Science Publishers, Inc., Hauppauge, New York, in press. 13- Nunomura A, Moreira PI, Zhu X, Cash AD, Smith MA, Perry G. The role of oxidative insult and neuronal survival in Alzheimer and Parkinson diseases. In: Alzheimer’s and Parkinson’s Diseases: Insights, Progress and Perspectives, Fisher A, Hanin I, Memo M, Stocchi F, Eds, Springer, New York, in press. XI 12- Moreira PI, Nunomura A, Honda K, Aliev G, Casadesus G, Zhu X, Smith MA, Perry G. (2007) The key role of oxidative stress in Alzheimer’s disease. In Oxidative Stress and Neurodegenerative Disorders, Qureshi, G.A. and Parvez, S.H. (Eds.). Elsevier B.V., Amsterdam, pp 267-281. 11- Moreira PI, Nunomura A, Zhu X, Smith MA, Perry G. Oxidative damage is the earliest change of Alzheimer disease: therapeutic opportunities. (2007) In: Research Progress in Alzheimer’s Disease and Dementia, Sun M-K, Ed. Nova Science Publisher, New York, pp 301-317. 10- Moreira PI, Siedlak SL, Santos MS, Oliveira CR, Fujioka H, Tabaton M, Nunomura A, Aliev G, Szweda LI, Zhu X, Smith MA, Perry G. (2006) Mitochondrial autophagocytosis in Alzheimer disease. In Alzheimer’s Disease: New Advances, Iqbal K, Winblad B, Avila J, Eds. Medimond S.r.l., Bologna, Italy, pp 373-376. 9- Moreira PI, Harris PLR, Zhu X, Santos MS, Oliveira CR, Smith MA, Perry G. (2006) Lipoic acid and n-acetyl cysteine protect against oxidative stress in fibroblasts from Alzheimer disease patients. In Alzheimer’s Disease: New Advances, Iqbal K, Winblad B, Avila J, Eds. Medimond S.r.l., Bologna, Italy, pp 541-544. 8- Moreira PI, Santos MS, Smith MA, Perry G, Oliveira CR. Is mitochondrial impairment a common link between Alzheimer’s disease and diabetes? A matter under discussion. In: Trends in Alzheimer’s Disease Research, Welsh EM, ed. Nova Science Publisher, New York, 2006, pp 259-279. 7- Nunomura A, Zhu X, Moreira PI, Smith MA, Perry G. Involvement of oxidative stress in early-stage of Alzheimer disease: implications for therapeutics. In: Trends in Alzheimer’s Disease Research, Welsh EM, Ed. Nova Science Publisher, New York, 2006 pp 161-183. 6- Moreira PI, Zhu X, Smith MA, Perry G. Antioxidant therapies in the prevention and treatment of Alzheimer disease. In: Oxidative Stress and Age-Related Neurodegeneration, Luo Y, Packer L, Eds. Taylor & Francis Group, Boca Raton, FL, 2006, pp 131-145. 5- Moreira PI, Santos MS, Oliveira CR. Mitochondrial dysfunction, diabetes and Alzheimer’s disease: Pieces from the same puzzle? In: Mitochondrial Pharmacology and Toxicology, Research Signpost Publisher, Kerala, India, 2006, pp 217-236. 4- Moreira PI, Zhu X, Nunomura A, Honda K, Lee, H, Aliev G, Smith MA, Perry G. Oxidative stress in Alzheimer disease: na overview. In: Perspectives in Neuroscience, Baloyannis SJ, Ed, Greece Society for Amelioration of the Quality of Life for Chronic Neurologic Patients, Thessalonikh, Greece, 2005, pp 419-433. 3- Moreira PI, Oliveira CR. Etiopatogenia da doença de Alzheimer e outras demências. In: A Doença de Alzheimer e Outras Demências em Portugal, Castro-Caldas A, Mendonça A, Eds, Lidel – edições técnicas Lda., Lisboa, 2005; pp 41-60. 2- Moreira PI, Nunomura A, Petot GJ, Aliev G, Smith MA, Perry G. Brain metabolic alterations are early signs in Alzheimer disease pathophysiology. In: Research and Practice in Alzheimer’s Disease, Special Issue on Nutrition, Cognitive Decline and Aging, Vellas B, Fitten LJ, Eds, Serdi, Paris, 2005; pp 61-65. XII 1- Moreira PI, Nunomura A, Honda K, Liu Q, Aliev G, Oliveira CR, Santos MS, Zhu X, Smith MA, Perry G. Stress and homeostatic regulation of oxidative damage in neurodegenerative disease. Proceedings of the XII Biennial Meeting of the Society for Free Radical Research, Puntarulo S, Boveris A, Eds, Medimond S. r. l., Bologna, 2004; pp 219-224. Teses Doutoramento: Moreira PI. 2007. Mitochondrial dysfunction in Alzheimer’s disease and diabetes: effect of compounds with antioxidant properties. (Disfunção mitocondrial na doença de Alzheimer e na diabetes: efeito de compostos com propriedades antioxidantes) Faculdade de Medicina, Universidade de Coimbra, Coimbra, Portugal. Mestrado: Moreira PI. 2002. Efeito do peptídeo Abeta25-35 no poro de permeabilidade transitória da mitocôndria: um estudo comparativo. Faculdade de Ciências e Tecnologia, Universidade de Coimbra, Coimbra, Portugal. Comunicações orais apresentadas em congressos 15- 1º Congresso Científico de Saúde: Doenças Neurodegenerativas Moreira PI, Santos MS, Perry G, Oliveira CR O papel da mitocôndria na doença de Alzheimer (Faculdade de Farmácia da Universidade de Lisboa, 22 a 23 de Novembro de 2007) 14- Fifth International Congress on Vascular Dementia Moreira PI, Santos MS, Seiça R, Oliveira CR Diabetes is a risk factor for Alzheimer disease: the role of mitochondria (Budapeste, Hungria, 8 a 11 de Novembro de 2007) 13- First Iberic Meeting on Medicinal Chemistry: Anticancer Agents – 1IMMC Moreira PI, Custódio J, Nunes E, Moreno A, Seiça R, Oliveira CR, Santos MS Liver mitochondria isolated from ovariectomized and tamoxifen-treated ovariectomized rat females are affected by estradiol (Régua, Portugal, 28 de Abril a 1 de Maio de 2007) 12- XV National Congress of Biochemistry Moreira PI, Custódio J, Moreno A, Oliveira CR, Santos MS Tamoxifen and estradiol: a deadly combination for cancer cells (Aveiro, Portugal, 8 a 10 de Dezembro de 2006) 11- 10th International Conference on Alzheimer’s Disease and Related Disorders Moreira PI, Siedlak SL, Santos MS, Oliveira CR, Fujioka H, Tabaton M, Nunomura A, Aliev G, Szweda LI, Zhu X, Smith MA, Perry G Mitochondrial autophagocytosis in Alzheimer disease (Madrid, Espanha, 15 a 20 de Julho de 2006) 10- International Courses on Toxicology “Smart Toxicology: Subcellular Targets of AntiCancer Therapy” Moreira PI, Custódio J, Moreno AJ, Oliveira CR, Santos MS Tamoxifen and estradiol lead to mitochondrial complex I failure (Centro de Neurociências e Biologia Celular, Universidade de Coimbra, 22 a 24 de Março de 2006) XIII 9- 4th International Congress on the Improvement of the Quality of Life in Dementia, Epilepsy, MS and Peripheral Neuropathies Moreira PI, Honda K, Santos MS, Oliveira CR, Smith MA, Zhu X, Nunomura A, Perry G Oxidative Stress in Alzheimer disease: role of antioxidants (Odessa, Ucrânia, 27 a 30 de Janeiro de 2006) 8- 4th International Congress on Vascular Dementia Moreira PI, Santos MS, Seiça R, Oliveira CR Brain mitochondria as a link between Alzheimer’s disease and diabetes (Porto, Potugal, 20 a 23 de Outubro de 2005). 7- 19ª Reunião do grupo de estudos do envelhecimento cerebral e demência Moreira PI, Santos MS, Seiça R, Oliveira CR Brain mitochondrial dysfunction is a common feature in both diabetes and Alzheimer’s disease (Tomar, Portugal, 3 a 4 de Junho de 2005). 6- Mitochondria: Between Life and Death – International Courses on Toxicology Moreira PI, Santos MS, Seiça R, Oliveira CR Effect of amyloid β-peptide on brain mitochondria isolated from diabetic rats (Centro de Neurociências e Biologia Celular, Universidade de Coimbra, Coimbra, Portugal, 27 a 29 de Abril 2005). 5- 1º Workshop de Bioquímica Clínica Moreira PI, Santos MS, Seiça R, and Oliveira CR Diabetes and Alzheimer’s Disease: Are Brain Mitochondria a Link Between Both Pathologies? (Porto, Portugal, 15 de Dezembro 2003). 4- 16st Luso-Spanish Congress on Free Radicals / 6th Portuguese Congress on Free Radicals in Chemistry, Biology and Medicine Moreira PI, Santos MS, Sena C, Seiça R, Oliveira C Role of Insulin in Brain Mitochondria Status of Type 1 Diabetic Rats. Does Amyloid β-Peptide Interfere with Mitochondrial Function? (Coimbra, Portugal, 4 a 6 de Dezembro 2003). 3- 16ª Reunião-Grupo de Estudos – Envelhecimento Cerebral e Demência Moreira PI, Santos MS, Moreno A, Seiça R, Oliveira CR Bioenergética mitocondrial e o envelhecimento (Tomar, Portugal, 14 e 15 de Junho 2002). 2- XXXII Reunião Anual da Sociedade Portuguesa de Farmacologia and XX Reunião de Farmacologia Clínica Moreira PI, Santos MS, Moreno A, Seiça R, Rego AC, Oliveira CR Mitochondria: a target for β-amyloid peptide (Coimbra, Portugal, 3 a 4 de Dezembro de 2001) 1- 14ª Reunião-Grupo de estudos: Envelhecimento Cerebral e Demência Moreira PI, Santos MS, Moreno A, Seiça R, Oliveira CR Mitocôndria e o envelhecimento: efeito do peptídeo Aβ25-35 (Luso, Portugal, 2 a 3 de Junho de 2000) XIV Comunicações em forma de poster 49- XXXVIII Reunião Anual da Sociedade Portuguesa de Farmacologia; XXV Reunião de Farmacologia Clínica; VII Reunião de toxicologia Silva FSG, Santos MS, Moreira PI, Santos-Silva A, Rocha-Pereira P, Custódio JBA 13-cis-retinoic acid induces changes on the oxidative phosphorylation capacity of rat liver mitochondria (Coimbra, Portugal, 5 a 7 Dezembro de 2007) 48- XXXVIII Reunião Anual da Sociedade Portuguesa de Farmacologia; XXV Reunião de Farmacologia Clínica; VII Reunião de toxicologia Custódio JBA, Silva FSG, Moreira PI, Santos-Silva A, Rocha-Pereira P, Santos MS Interactions of 13-cis-retinoic acid with adenosine nucleotide translocase: mechanisms of mitochondrial permeability transition induction (Coimbra, Portugal, 5 a 7 Dezembro de 2007) 47- XXXVIII Reunião Anual da Sociedade Portuguesa de Farmacologia; XXV Reunião de Farmacologia Clínica; VII Reunião de toxicologia Correia S, Carvalho C, Santos MS, Proença T, Nunes E, Duarte AI, Monteiro P, Seiça R, Oliveira CR, Moreira PI Metformin counteracts the oxidative imbalance that occurs in the brain of diabetic GotoKakizaki rats (Coimbra, Portugal, 5 a 7 Dezembro de 2007) 46- XXXVIII Reunião Anual da Sociedade Portuguesa de Farmacologia; XXV Reunião de Farmacologia Clínica; VII Reunião de toxicologia Capote T, Silva FSG, Marques P, Santos MS, Moreira PI, Santos-Silva A, Rocha-Pereira P, Custódio JBA Effect of acitretin in the mitochondrial permeability transition pore opening (Coimbra, Portugal, 5 a 7 Dezembro de 2007) 45- XXXVIII Reunião Anual da Sociedade Portuguesa de Farmacologia; XXV Reunião de Farmacologia Clínica; VII Reunião de toxicologia Carvalho C, Correia S, Santos MS, Seiça R, Oliveira CR, Moreira PI Metformin promotes rat liver mitochondria impairment (Coimbra, Portugal, 5 a 7 Dezembro de 2007) 44- Fifth International Congress on Vascular Dementia Moreira PI, Siedlak SR, Wang X, Santos MS, Oliveira CR, Tabaton M, Nunomura A, Szweda LI, Aliev G, Smith MA, Zhu X, Perry G Autophagocytosis of mitochondria is prominent in Alzheimer disease (Budapeste, Hungria, 8 a 11 de Novembro de 2007) 43- 2007 European Meeting of the Society for Free Radical Research Moreira PI, Custódio J, Nunes E, Moreno A, Seiça R, Oliveira CR, Santos MS Effects of estradiol on liver mitochondrial function of ovariectomized and tamoxifen-treated female rats (Vilamoura, Portugal, 10 a 13 de Outubro de 2007) 42- European Congress – Society for Free Radical Research Moreira PI, Custódio J, Nunes E, Moreno A, Seiça R, Oliveira CR, Santos MS Effects of estradiol on mitochondrial function of ovariectomized and tamoxifen-treated female rats (Vilamoura, Portugal, 10 a 13 de Outubro de 2007) 41- XV National Congress of Biochemistry Moreira PI, Santos MS, Nunes E, Moreno A, Seiça R, Custódio J Tamoxifen affects liver mitochondrial function in ovariectomized and tamoxifen-treated female rats (Aveiro, Portugal, 8 a 10 de Dezembro de 2006) XV 40- V Congresso de Investigação em Medicina – Pedagogia e Ciência Moreira PI, Santos MS, Nunes E, Moreno A, Seiça R, Custódio J O estradiol afecta a função de mitocôndrias isoladas de fígado de fêmeas ovariectomizadas e tratadas com tamoxifeno (Coimbra, Portugal, 23 a 24 de Novembro de 2006) 39- 10th International Conference on Alzheimer’s Disease and Related Disorders Moreira PI, Harris PL, Zhu X, Santos MS, Oliveira CR, Smith MA, Perry G Lipoic acid and N-acetyl cysteine protect against oxidative stress in fibroblasts from Alzheimer disease patients (Madrid, Espanha, 15 a 20 de Julho de 2006) 38- 9ª Reunião Científica Nacional da Sociedade Portuguesa de Neurociências Moreira PI, Santos MS, Sena C, Seiça R, Oliveira CR Insulin protects against amyloid β-peptide toxicity in brain mitochondria of diabetic rats (Luso, Portugal, 19 a 20 de Maio de 2005) 37- XIV Congresso Nacional de Bioquímica Moreira PI, Santos MS, Sena C, Seiça R, Oliveira CR Insulin reverses amyloid β-peptide toxicity in brain mitochondria of diabetic rats (Vilamoura, Portugal, 2 a 4 de Dezembro de 2004) 36- 2nd Spanish and Portuguese Congress on Free Radicals Moreira PI, Custódio J, Oliveira C, Santos MS Tamoxifen prevents brain mitochondrial injury induced by oxidative stress-related events (Bilbao, Espanha, 25 a 27 de Novembro de 2004) 35- IV Congresso de Investigação em Medicina Moreira PI, Santos MS, Seiça R, Oliveira CR O peptídeo β-amilóide potencia a disfunção mitocondrial induzida pelo envelhecimento (Coimbra, Portugal, 17 a 18 de Novembro de 2004) 34- 16st Luso-Spanish Congress on Free Radicals / 6th Portuguese Congress on Free Radicals in Chemistry, Biology and Medicine Sena CM, Santos MS, Nunes E, Moreira PI, Rolo AP, Gomes A, Proença T, Seiça RM Effect of coenzyme Q10 on the antioxidant status of type 2 diabetic rats (Coimbra, Portugal, 4 a 6 de Dezembro 2003) 33- 16st Luso-Spanish Congress on Free Radicals / 6th Portuguese Congress on Free Radicals in Chemistry, Biology and Medicine Seiça RM, Nunes E, Gomes A, Santos MS, Moreira PI, Rolo AP, Proença T, Sena CM Aging and anti-oxidant defense system in normal Wistar rats (Coimbra, Portugal, 4 a 6 de Dezembro 2003) 32- Society for Neuroscience – 33th Annual Meeting Moreira PI, Santos MS, Moreno A, Seiça R, Oliveira C STZ-Induced Diabetes and Brain Mitochondria Function: Role of Amyloid β-Peptide (New Orleans, 8 a 12 de Novembro de 2003) 31- 17ª Reunião do Grupo de Estudos – Envelheciemnto Cerebral e Demência Moreira PI, Santos MS, Moreno A, Oliveira C Aging as a risk factor for brain mitochondria impairment (Curia, 13 a 14 de Junho de 2003) 30- 8th Meeting of the Portuguese Society for Neurosciences Moreira PI, Santos MS, Custodio J, Oliveira CR Is the antiestrogen drug tamoxifen a neuroprotective agent? (Curia, 12 a 13 de Junho de 2003) XVI 29- The Physiological Society Spring Workshop 2003 – Receptors and Cell Signalling in Oxidative Stress Moreira PI, Santos MS, Moreno A, Seiça R, Oliveira CR Increased vulnerability of diabetic brain mitochondria to aging and amyloid β-induced toxicity (Budapeste, 3 a 5 de Abril de 2003) 28- Biochemical Aspects of Health and Disease – Biochemical Society, Meeting 678 Moreira PI, Santos MS, Moreno A, Oliveira C Aging, amyloid β-peptide and brain mitochondria dysfuntion (Londres, 16 a 18 de Dezembro de 2002) 27- XIII Congresso Nacional de Bioquímica Moreira PI, Santos MS, Moreno A, Seiça R, Oliveira C Diabetes and Alzheimer’s Disease: Is there a mitochondrial link? (Lisboa, 5 a 7 de Dezembro de 2002) 26- XIII Congresso Nacional de Bioquímica Matos MJ, Moreira PI, Peixoto F, Seiça R, Santos MS Age-related alterations in fatty acid composition of heart mitochondria isolated from diabetic Goto-Kakizaki rats (Lisboa, 5 a 7 de Dezembro de 2002) 25- III Congresso de Investigação em Medicina Moreira PI, Santos MS, Moreno A, Seiça R, Oliveira C Aging increases amyloid β-peptide-induced mitochondrial dysfunction (Universidade de Coimbra, 12 a 13 de Novembro de 2002) 24- The 3rd Neurobiology of Aging – Molecular and Cellular Basis of Synaptic Loss and Dysfunction Moreira PI, Santos MS, Moreno A, Oliveira C Aβ Peptide Potentiates Age-Related Brain Mitochondrial Dysfunction (Orlando, 31 de Outubro a 1 de Novembro de 2002) 23- Society for Neuroscience – 32th Annual Meeting Moreira PI, Santos MS, Moreno A, Seiça R, Oliveira C Age-Associated Susceptibility of Diabetic Brain Mitochondria to β-amyloid Peptide (Orlando, 2 a 8 de Novembro de 2002) 22- XIth Biennial Meeting of the Society for Free Radical Research International Moreira PI, Santos MS, Moreno A, Seiça R, Oliveira C Brain Mitochondria and Aging: Role of Aβ Peptide (Paris, 16 a 20 de Julho de 2002) 21- 5º Congresso Português de Diabetes Moreira PI, Santos MS, Moreno A, Seiça R, Oliveira C Diabetes e Doença de Alzheimer: Papel da mitocôndria (Vilamoura-Marinotel, 20 a 23 de Março de 2002) 20- 5º Congresso de Radicais Livres em Química, Biologia e Medicina Moreira PI, Santos MS, Moreno A, Oliveira C Susceptibility of brain mitochondria to aging and amyloid β-peptide (Universidade do Porto, Portugal, 13 a 15 de Dezembro de 2001) XVII 19- 2nd Neurobiology of Aging Conference Oliveira CR, Moreira PI, Duarte AI, Melo JB, Rego AC, Moreno A, Santos MS Aging, Oxidative stress and β-amyloid susceptibility (San Diego, U.S.A., 8 a 9 de Novembro de 2001) 18- 7ª Reunião da Sociedade Portuguesa de Neurociências Moreira PI, Santos MS, Moreno A, Rego AC, Oliveira C Can we extrapolate data obtained from other tissues to brain? (Luso, Portugal, 13 a 14 de Setembro de 2001) 17- Advanced FEBS Course “Mitochondria in the cell life and death” Moreira PI, Santos MS, Moreno A, Rego AC, Oliveira C Mitochondria permeability transition: effect of amyloid β-pepide (Moscovo, Rússia, 2 a 7 de Setembro de 2001) 16- 27th Meeting of the Federation of European Biochemical Societies (FEBS) Moreira PI, Santos MS, Moreno A, Seiça R, Oliveira C Mitochondria, aging and diabetes: the role of the amyloid β-peptide (Lisboa, Portugal, 30 de Junho a 5 de Julho de 2001) 15- 15ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência Moreira PI, Santos MS, Moreno A, Seiça R, Oliveira C Envelhecimento e a disfunção mitocondrial: efeito do peptídeo Aβ25-35 (Peniche, Portugal, 1 a 3 de Junho de 2001) 14- II Congresso de Investigação em Medicina Moreira PI, Santos MS, Moreno A, Seiça R, Oliveira C Envelhecimento, diabetes e susceptibilidade da mitocôndria (Universidade de Coimbra, Portugal, 9 a 11 de Novembro de 2000) ao peptídeo Aβ25-35 13- 30th Annual Meeting of Society for Neuroscience Moreira PI, Santos MS, Moreno A, Oliveira CR Permeability transition of brain mitochondria: effect of Aβ25-35 peptide (New Orleans, U.S.A., 4 a 9 de Novembro de 2000) 12- XII Congresso Nacional de Bioquímica Moreira PI, Santos MS, Moreno A, Seiça R, Oliveira C Mitochondrial aging: role of β-amyloid peptide (Póvoa de Varzim, Portugal, 28 a 30 de Setembro de 2000) 11- First International Conference - Metals and Brain: From Neurochemistry to Neurodegeneration Moreira PI, Pedrosa RP, Cardoso S, Pereira C, Santos MS, Fernandes MAS, Alpoim MC, Oliveira CR The role of metal ions in oxidative stress and mitochondrial dysfunction in Alzheimer's disease (Universidade de Padova, Itália, 20 a 23 de Setembro de 2000) 10- 14ª Reunião-Grupo de estudos: Envelhecimento Cerebral e Demência Moreira PI, Santos MS, Moreno A, Seiça R, Oliveira C Mitocôndria e o envelhecimento: efeito do peptídeo Aβ25-35 (Luso, Portugal, 2 a 3 de Junho de 2000) XVIII 9- FEBS Advanced Course 2000-03 “Expression and regulation of mitochondrial oxidative phosphorylation and disorders in human pathology” Moreira PI, Santos MS, Moreno A, Oliveira CR Effect of the amyloid β-peptide on brain bioenergetics (Martina Franca, Itália, 5 a 10 de Março de 2000) 8- IV Congresso de Radicais Livres em Química, Biologia e Medicina Moreira PI, Santos MS, Seiça R, Oliveira C Influence of diabetes on rat brain mitochondrial bioenergetics: effect of Aβ25-35 peptide (Tróia, Portugal, 22 a 24 de Setembro de 1999) 7- VI Reunião da Sociedade Portuguesa de Neurociências Moreira PI, Santos MS, Seiça R, Oliveira C Effect of Aβ25-35 peptide on the brain mitochondrial bioenergetics (Lisboa, Portugal, 7 a 8 de Setembro de 1999) 6- VI Reunião da Sociedade Portuguesa de Neurociências Pereira C, Moreira PI, Oliveira CR Potentiation of amyloid beta-peptide toxicity by zinc on a PC12 cell line (Lisboa, Portugal, 7 a 8 de Setembro de 1999) 5- V Reunião da Sociedade Portuguesa de Neurociências Duarte AI, Moreira PI, Santos MS, Oliveira CR Vinpocetine protects synaptosomes from oxidative stress (Cascais, Portugal, 15 a 17 de Dezembro de 1998) 4- V Reunião da Sociedade Portuguesa de Neurociências Pereira C, Moreira PI, Seiça R, Santos MS, Oliveira C The synaptosomal susceptibility to Aβ-induced toxicity is decreased in GK (Goto-Kakizaki) diabetic rats (Cascais, Portugal, 15 a 17 de Dezembro de 1998) 3- XI Congresso Português de Bioquímica Moreira PI, Pereira C, Santos MS, Oliveira C Effect of zinc in citotoxicity of amyloid β-peptide (Tomar, Portugal, 28 a 30 de Novembro de 1998) 2- IX Biennial Meeting International Society for Free Radical Research Santos MS, Duarte AI, Moreira PI, Oliveira CR Synaptosomal response to oxidative stress: effect of vinpocetine (São Paulo, Brasil, 7 a 11 de Setembro de 1998) 1- IV Reunião da Sociedade Portuguesa de Neurociências Moreira PI, Duarte AI, Santos MS, Oliveira CR Under oxidative stress glutamate reverts the aluminium-induced metabolic changes in synaptosomes (Coimbra, Portugal, 11 a 13 de Dezembro de 1997) XIX