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Clínica Universitária de Reumatologia – Faculdade de Medicina. Universidade de
Coimbta
Serviço de Reumatologia. Centro Hospitalar e Universitário de Coimbra
PUBLICAÇÕES
•
Artigos em revistas indexadas. Full papers in Pub-Med indexed Journals
 Livros
o Capítulos de Livros
2014
• Psychological Factors Associated with Response to Treatment in Rheumatoid
Arthritis. (2014). Santiago T, Geenen R, Jacobs WG, Da Silva JA. Curr Pharm Des.
2014 Aug 25. [Epub ahead of print]
• DAS28, CDAI and SDAI cut-offs do not translate the same information: results
from the Rheumatic Diseases Portuguese Register Reuma.pt. (2014) Martins FM,
da Silva JA, Santos MJ, Vieira-Sousa E, Duarte C, Santos H2, Costa JA, PimentelSantos FM, Cunha I, Cunha Miranda L, Nóvoa T, Cruz M, Bernardes M, Araujo D,
Pereira Silva JA, Silva JC, Branco JC, Gomes JA, Faustino A, Fonseca JE, Canhão
H3. Rheumatology (Oxford). 2014 Aug 29. pii: keu313. [Epub ahead of print]
• Cross-cultural validation of the portuguese version of the educational needs
assessment tool (PortENAT) (2014). A. Cruz, P. Machado, J. Hill, M. Campos, J.
Apostolo, A. Marques, A. Malcata and M. Ndosi. Acta Reumatol Port, Jan 7. [Epub
ahead of print]
• Polymyalgia Rheumatica (PMR) Special Interest Group at OMERACT 11:
outcomes of importance for patients with PMR (2014). S. L. Mackie, S. Arat, J. da
Silva, C. Duarte, S. Halliday, R. Hughes, M. Morris, C. T. Pease, J. W. Sherman, L. S.
Simon, M. Walsh, R. Westhovens, S. Zakout and J. R. Kirwan. J Rheumatol, 41: 4,
819-23.
• The Portuguese Society of Rheumatology position paper on the use of
biosimilars (2014). J. E. Fonseca, J. Goncalves, F. Araujo, I. Cordeiro, F. Teixeira,
H. Canhao, J. A. Silva, S. Garces, L. C. Miranda, S. Ramiro, A. Roxo, F. M.
Pimentel-Santos, V. Tavares, A. Neto, A. Sepriano, A. Malcata, A. Faustino, C. Silva,
C. Ambrosio, C. Duarte, C. Miguel, F. Barcelos, H. Santos, I. Cunha, J. C. Ramos, J.
A. Gomes, J. B. Pimentao, L. Costa, L. Mauricio, M. Silva, M. Bernardes, M. Bogas,
P. C. Coelho, P. Monteiro, R. Aguiar, R. Andre, R. Leitao, S. Pimenta, T. Meirinhos,
S. Fernandes, V. Las and W. Castelao. Acta Reumatol Port, 39: 1, 60-71.
• Safety of low- to medium-dose glucocorticoid treatment in rheumatoid arthritis:
myths and reality over the years (2014). T. Santiago and J. A. da Silva. Ann N Y
Acad Sci, 1318: 1, 41-9.
• Coexisting primary Sjogren's syndrome and sarcoidosis: coincidence,
mutually exclusive conditions or syndrome? (2014). T. Santiago, M. Santiago, J.
Rovisco, J. Ferreira, C. Duarte, A. Malcata and J. A. Da Silva. Rheumatol Int, Apr 28.
[Epub ahead of print]
• Milwaukee shoulder (and knee) syndrome (2014). T. Santiago, M. Coutinho, A.
Malcata and J. A. da Silva. BMJ Case Rep, 2014: May 15;2014. pii: bcr2013202183.
doi: 10.1136/bcr-2013-202183.
• Portuguese Recommendations for the Diagnosis and Management of Gout
(2014). F. Araujo, I. Cordeiro, F. Teixeira, J. Rovisco, S. Ramiro, A. F. Mourao, J. A.
Costa, J. B. Pimentao, A. Malcata, M. J. Santos and J. C. Branco. Acta Reumatol
Port, Apr-Jun;39(2):158-171.
• Identification of clinical predictors of flare in systemic lupus erythematosus
patients: a 24-month prospective cohort study (2014). L. Ines, C. Duarte, R. S.
Silva, A. S. Teixeira, F. P. Fonseca and J. A. da Silva. Rheumatology (Oxford), 53: 1,
85-9.
• Nailfold capillary abnormalities in erectile dysfunction of systemic sclerosis: a
EUSTAR group analysis (2014). A. D. Keck, C. Foocharoen, E. Rosato, V. Smith, Y.
Allanore, O. Distler, B. Stamenkovic, J. A. Pereira Da Silva, S. Hadj Khelifa, L. N.
Denisov, E. Hachulla, P. Garcia de la Pena Lefebvre, J. Sibilia, P. Airo, P.
Caramaschi, U. Muller-Ladner, P. Wiland and U. A. Walker. Rheumatology (Oxford),
53: 4, 639-43.
• Measurement invariance of the Illness Invalidation Inventory (3*I) across
language, rheumatic disease and gender (2014). M. B. Kool, R. van de Schoot, I.
Lopez-Chicheri Garcia, R. Mewes, J. A. Da Silva, K. Vangronsveld, A. A. Wismeijer,
M. A. Lumley, H. van Middendorp, J. W. Bijlsma, G. Crombez, W. Rief and R.
Geenen. Ann Rheum Dis, 73: 3, 551-6.
• Paraneoplastic sclerodermiform syndrome - case report (2014). J. Rovisco, S.
Serra, P. Abreu, M. Coutinho, T. Santiago, L. Ines and J. A. da Silva. Acta Reumatol
Port, 39: 1, 87-90.
• Updating the OMERACT filter: implications of filter 2.0 to select outcome
instruments through assessment of "truth": content, face, and construct
validity. (2014). Tugwell P, Boers M, D'Agostino MA, Beaton D, Boonen A, Bingham
CO 3rd, Choy E, Conaghan PG, Dougados M, Duarte C, Furst DE, Guillemin F,
Gossec L, Heiberg T, van der Heijde DM, Hewlett S, Kirwan JR, Kvien TK, Landewé
RB, Mease PJ, Østergaard M, Simon L, Singh JA, Strand V, Wells G. J Rheumatol.
2014 May;41(5):1000-4.
• Rheumatology telephone advice line – Experience of a Portuguese department
(2014). R. Ferreira, A. Marques, A. Mendes, J. A. P. da Silva. Acta Reumatol Port,
Apr 30. [Epub ahead of print]
• Pigmented Villonodular Synovitis: a recurrent case with atypical location and
extra-articular extension. (2014) M. Coutinho, A. Laranjo, J. A. P. da Silva, J.
Casanova. Acta Reumatol Port, [Epub ahead of print]
• Macrophagic myofasciitis and vaccination: Consequence or coincidence?
(2014). T Santiago, O Rebelo, L Negrão, A Matos. Rheumatol Int. 2014 Jun 13 (epub
ahead of print)
•
2013
• Learning, teaching and evaluation of rheumatological skills (2013). M. Doherty,
J. W. Bijlsma and J. A. da Silva. Best Pract Res Clin Rheumatol, 27: 2, 121.
• Developing
a
professional
approach
to
work-based
assessments
in
rheumatology. (2013). Haines C, Dennick R, da Silva JAP. Best Pract Res Clin
Rheumatol. Apr;27(2):123-36.
• Potential roles for CD8(+) T cells in rheumatoid arthritis (2013). H. Carvalheiro, J.
A. da Silva and M. M. Souto-Carneiro. Autoimmun Rev, 12: 3, 401-9.
• Central nervous system vasculitis (2013). J. Rovisco, T. Santiago and L. Isidoro.
Acta Reumatol Port, 38: 4, 306.
• Validation of the educational needs assessment tool as a generic instrument
for rheumatic diseases in seven European countries (2013). M. Ndosi, A.
Bremander, B. Hamnes, M. Horton, M. L. Kukkurainen, P. Machado, A. Marques, J.
Meesters, T. A. Stamm, A. Tennant, J. de la Torre-Aboki, T. P. Vliet Vlieland, H. A.
Zangi and J. Hill. Ann Rheum Dis, Aug 6. doi: 10.1136/annrheumdis-2013-203461.
[Epub ahead of print]
• Anti-tumor necrosis factor and new bone formation in ankylosing spondylitis:
the controversy continues (2013). P. Machado. Arthritis Rheum, 65: 10, 2537-40.
• Longitudinal observational study of sporadic inclusion body myositis:
implications for clinical trials (2013). A. Cortese, P. Machado, J. Morrow, L. Dewar,
A. Hiscock, A. Miller, S. Brady, D. Hilton-Jones, M. Parton and M. G. Hanna.
Neuromuscul Disord, 23: 5, 404-12.
• Update in inclusion body myositis (2013). P. Machado, S. Brady and M. G. Hanna.
Curr Opin Rheumatol, 25: 6, 763-71.
• Spondyloarthritis: Is it time to replace BASDAI with ASDAS? (2013). P.
Machado and R. Landewe. Nat Rev Rheumatol, 9: 7, 388-90.
• Ankylosing spondylitis patients with and without psoriasis do not differ in
disease phenotype (2013). P. Machado, R. Landewe, J. Braun, X. Baraliakos, K. G.
Hermann, B. Hsu, D. Baker and D. van der Heijde. Ann Rheum Dis, 72: 6, 1104-7.
• A FRAX model for the estimation of osteoporotic fracture probability in
Portugal (2013). A. Marques, A. Mota, H. Canhao, J. C. Romeu, P. Machado, A.
Ruano, A. P. Barbosa, A. A. Dias, D. Silva, D. Araujo, E. Simoes, F. Aguas, I.
Rosendo, I. Silva, J. Crespo, J. D. Alves, L. Costa, M. Mascarenhas, O. Lourenco, P.
L. Ferreira, R. Lucas, R. Roque, J. C. Branco, V. Tavares, H. Johansson, J. Kanis
and J. A. Pereira da Silva. Acta Reumatol Port, 38: 2, 104-12.
• Hypermobility syndromes from the clinician's perspective: an overview (2013).
J. W. Jacobs and J. A. da Silva. Acta Reumatol Port, Apr-Jun;39(2):124-136.
• A case of infliximab-induced lupus in a patient with ankylosing spondylitis: is it
safe to switch to another anti-TNF-alpha agent? (2013). T. Santiago, M. G.
Santiago, J. Rovisco, C. Duarte, A. Malcata and J. A. da Silva. Clin Rheumatol, 32:
12, 1819-22.
• NK cells dysfunction in systemic lupus erythematosus: relation to disease
activity (2013). A. Henriques, L. Teixeira, L. Ines, T. Carvalheiro, A. Goncalves, A.
Martinho, M. L. Pais, J. A. da Silva and A. Paiva. Clin Rheumatol, 32: 6, 805-13.
• EULAR recommendations for the non-pharmacological core management of
hip and knee osteoarthritis (2013). L. Fernandes, K. B. Hagen, J. W. Bijlsma, O.
Andreassen, P. Christensen, P. G. Conaghan, M. Doherty, R. Geenen, A. Hammond,
I. Kjeken, L. S. Lohmander, H. Lund, C. D. Mallen, T. Nava, S. Oliver, K. Pavelka, I.
Pitsillidou, J. A. da Silva, J. de la Torre, G. Zanoli and T. P. Vliet Vlieland. Ann
Rheum Dis, 72: 7, 1125-35.
• EULAR evidence-based and consensus-based recommendations on the
management of medium to high-dose glucocorticoid therapy in rheumatic
diseases (2013). N. Duru, M. C. van der Goes, J. W. Jacobs, T. Andrews, M. Boers,
F. Buttgereit, N. Caeyers, M. Cutolo, S. Halliday, J. A. Da Silva, J. R. Kirwan, D. Ray,
J. Rovensky, G. Severijns, R. Westhovens and J. W. Bijlsma. Ann Rheum Dis, 72: 12,
1905-13.
• Distribution and functional plasticity of peripheral blood Th(c)17 and Th(c)1 in
rheumatoid arthritis (2013). A. Henriques, V. Gomes, C. Duarte, S. Pedreiro, T.
Carvalheiro, M. Areias, A. Caseiro, A. J. Gabriel, P. Laranjeira, M. L. Pais, J. A. da
Silva and A. Paiva. Rheumatol Int, 33: 8, 2093-9.
• Exercise-induced pulmonary hypertension in scleroderma patients: a common
finding but with elusive pathophysiology (2013). R. Baptista, S. Serra, R. Martins,
M. J. Salvador, G. Castro, M. Gomes, L. Santos, P. Monteiro, J. A. da Silva and M.
Pego. Echocardiography, 30: 4, 378-84.
• Primary
synovial
chondromatosis
of
the
ankle
joint
presenting
monoarthritis. (2013).T Santiago, C Mariano. BMJ Case Rep. 2013 Dec 10.
as
2012
 EULAR Texbook of Rheumatology. 20012. Editor: JWJ Bijlsma. Co-editors:
Gerd R Burmester, José António P. da Silva, Karen Lisbeth Faarvang, Eric
Hachulla, Xavier Mariette. BMJ Publishing Group Ltd. Londres. 1ª Edição. 2012.
o Diagnostic Stragies in Rheumatology. José A.P.da Silva, Michelle Hui and Mike
Doherty. (2012). In EULAR Texbook of Rheumatology. 20012. Editor: JWJ Bijlsma.
Co-editors: Gerd R Burmester, José António P. da Silva, Karen Lisbeth Faarvang,
Eric Hachulla, Xavier Mariette. BMJ Publishing Group Ltd. Londres. 1ª Edição. 2012.
o
Rehabilitation aspects of rheumatic diseases. Theodora P.M. Vliet Vlieland,
Cornelia H. van den Ende, José António P. da Silva (2012). In EULAR Texbook of
Rheumatology. 20012. Editor: JWJ Bijlsma. Co-editors: Gerd R Burmester, José
António P. da Silva, Karen Lisbeth Faarvang, Eric Hachulla, Xavier Mariette. BMJ
Publishing Group Ltd. Londres. 1ª Edição. 2012.
• [Recommendations
of
the
Portuguese
Society
of
Rheumatology:
a
contribution towards improving the quality of health care] (2012). P. Machado,
M. J. Santos and J. E. Fonseca. Acta Reumatol Port, 37: 1, 7-8.
• MRI inflammation and its relation with measures of clinical disease activity and
different treatment responses in patients with ankylosing spondylitis treated
with a tumour necrosis factor inhibitor (2012). P. Machado, R. B. Landewe, J.
Braun, X. Baraliakos, K. G. Hermann, B. Hsu, D. Baker and D. van der Heijde. Ann
Rheum Dis, 71: 12, 2002-5.
• MRI inflammation at the vertebral unit only marginally predicts new
syndesmophyte formation: a multilevel analysis in patients with ankylosing
spondylitis (2012). D. van der Heijde, P. Machado, J. Braun, K. G. Hermann, X.
Baraliakos, B. Hsu, D. Baker and R. Landewe. Ann Rheum Dis, 71: 3, 369-73.
• Who are the young professionals working in the field of rheumatology in
Europe and what are their needs? An EMEUNET (EMerging EUlar NETwork)
survey (2012). C. Gaujoux-Viala, R. Knevel, P. Mandl, G. Nagy, M. Frank, P.
Machado, G. Hatemi, M. H. Buch, D. Aletaha and L. Gossec. Ann Rheum Dis, 71: 8,
1432-3.
• [Low-impact humeral fracture revealer of chondrosarcoma: a case of exuberant
tissue destruction] (2012). M. Coutinho, A. Laranjo and J. Casanova. Acta
Reumatol Port, 37: 1, 99-101.
• 2011 Portuguese recommendations for the use of biological therapies in
patients with psoriatic arthritis (2012). P. Machado, M. Bogas, A. Ribeiro, J. Costa,
A. Neto, A. Sepriano, A. Raposo, A. R. Cravo, A. Vilar, C. Furtado, C. Ambrosio, C.
Miguel, C. Vaz, C. Catita, D. Nour, D. Araujo, E. Vieira-Sousa, F. Teixeira, F.
Brandao, H. Canhao, I. Cordeiro, I. Goncalves, J. Ferreira, J. E. Fonseca, J. A. da
Silva, J. Romeu, J. Ferreira, L. Costa, L. Mauricio, L. Cunha-Miranda, M. Parente, M.
Coutinho, M. Cruz, M. Oliveira, M. J. Salvador, M. J. Santos, P. Pinto, P. Valente, P.
Abreu, R. Roque, S. Ramiro, S. Capela, V. Las and A. Barcelos. Acta Reumatol Port,
37: 1, 26-39.
• Portuguese recommendations for the use of biological therapies in patients
with axial spondyloarthritis--December 2011 update (2012). P. Machado, A.
Bernardo, A. R. Cravo, A. Rodrigues, A. Malcata, D. Nour, E. Vieira-Sousa, F.
Godinho, F. Pimentel, H. Canhao, H. Santos, I. Cunha, J. E. Fonseca, J. Costa, L.
Costa, L. Cunha-Miranda, L. Mauricio, M. Cruz, M. J. Santos, M. Bernardes, M.
Bogas, P. Valente, S. Ramiro and A. Barcelos. Acta Reumatol Port, 37: 1, 40-7.
• [Characterization of patients with ankylosing spondylitis in hidrokinesitherapy
- a multidimensional assessment] (2012). F. Januario, J. Almeida, S. Serra, C.
Amaral, P. Machado and L. A. Rodrigues. Acta Med Port, 25: 5, 301-7.
• Churg-Strauss syndrome: case series. (2012). Alfaro TM, Duarte C, Monteiro R,
Simão A, Calretas S, Nascimento Costa JM. Rev Port Pneumol. Mar-Apr;18(2):86-92.
• Comparative effectiveness and predictors of response to tumour necrosis
factor inhibitor therapies in rheumatoid arthritis (2012). H. Canhao, A. M.
Rodrigues, A. F. Mourao, F. Martins, M. J. Santos, J. Canas-Silva, J. Polido-Pereira,
J. A. Pereira Silva, J. A. Costa, D. Araujo, C. Silva, H. Santos, C. Duarte, J. A. da
Silva, F. M. Pimentel-Santos, J. C. Branco, E. W. Karlson, J. E. Fonseca and D. H.
Solomon. Rheumatology (Oxford), 51: 11, 2020-6.
• [Septic arthritis and gout--a case report] (2012). S. Serra, P. Monteiro, A. Vaz, E.
Pires, R. Monteiro, L. Ines, M. J. Salvador, J. Bernardo and A. Malcata. Acta
• Tolerogenic versus inflammatory activity of peripheral blood monocytes and
dendritic cells subpopulations in systemic lupus erythematosus (2012). T.
Carvalheiro, A. Rodrigues, A. Lopes, L. Ines, I. Velada, A. Ribeiro, A. Martinho, J. A.
Silva, M. L. Pais and A. Paiva. Clin Dev Immunol, 2012: 934161, doi:
10.1155/2012/934161.
• Th17 cells in systemic lupus erythematosus share functional features with
Th17 cells from normal bone marrow and peripheral tissues (2012). A.
Henriques, L. Ines, M. L. Pais, J. A. da Silva and A. A. Paiva. Clin Rheumatol, 31: 3,
483-91.
• Functional characterization of peripheral blood dendritic cells and monocytes
in systemic lupus erythematosus (2012). A. Henriques, L. Ines, T. Carvalheiro, M.
Couto, A. Andrade, S. Pedreiro, P. Laranjeira, J. M. Morgado, M. L. Pais, J. A. da
Silva and A. Paiva. Rheumatol Int, 32: 4, 863-9.
• Smokers in early axial spondyloarthritis have earlier disease onset, more
disease activity, inflammation and damage, and poorer function and healthrelated quality of life: results from the DESIR cohort (2012). H. Y. Chung, P.
Machado, D. van der Heijde, M. A. D'Agostino and M. Dougados. Ann Rheum Dis,
71: 6, 809-16.
• CoReumaPt protocol: the Portuguese cohort of rheumatic diseases (2012). P. A.
Laires, H. Canhao, D. Araujo, J. E. Fonseca, P. Machado, A. F. Mourao, S. Ramiro, J.
C. Romeu, M. J. Santos, I. Silva, J. A. Silva, E. Sousa, V. Tavares, N. Gouveia and J.
C. Branco. Acta Reumatol Port, 37: 1, 18-24.
• Pigmented Villonodular Synovitis: a diagnostic challenge. Review of 28 cases.
(2012). Coutinho M, Laranjo A, Casanova J. Acta Reumatol Port. 37(4):335-41.
• [Portuguese recommendations for pain management by pharmocotherapy in
inflammatory arthritis] (2012). I. Silva, A. F. Mourao, S. Ramiro, A. Rodrigues, C.
Miguel, L. Sampaio, A. Faustino, C. Vaz, H. Canhao, M. Cruz, A. Neto, A. R. Cravo,
A. Ribeiro, A. Brandao, D. Peixoto, D. Medeiros, F. A. Santos, F. Teixeira, I.
Goncalves, J. P. Silva, J. M. Gomes, L. Mauricio, E. Simoes, M. J. Salvador, M. Silva,
P. Nero, R. Roque, R. Barros, R. Andre, S. Falcao, S. Serra, V. Tavares and J. C.
Branco. Acta Reumatol Port, 37: 2, 160-74.
• Hypovitaminosis D in patients admitted to an internal medicine ward. (2012). T
Santiago, M Rebelo, J Porto, N Silva, J Vieira, JM Nascimento Costa. Acta Med Port.
25:68-76.
2011
• European League Against Rheumatism recommendations for the inclusion of
patient representatives in scientific projects (2011). M. P. de Wit, S. E. Berlo, G.
J. Aanerud, D. Aletaha, J. W. Bijlsma, L. Croucher, J. A. Da Silva, B. Glusing, L.
Gossec, S. Hewlett, M. Jongkees, D. Magnusson, M. Scholte-Voshaar, P. Richards,
C. Ziegler and T. A. Abma. Ann Rheum Dis, 70: 5, 722-6.
• Impact of impaired morning function on the lives and well-being of patients
with rheumatoid arthritis (2011). J. A. da Silva, S. Phillips and F. Buttgereit. Scand
J Rheumatol Suppl, 125: 6-11.
• The value of conventional radiographs in undifferentiated arthritis: a
systematic review (2011). R. Koevoets, P. Machado, C. Bombardier and D. M. van
der Heijde. J Rheumatol Suppl, 87: 26-30.
• Multinational evidence-based recommendations on how to investigate and
follow-up
undifferentiated
peripheral
inflammatory
arthritis:
integrating
systematic literature research and expert opinion of a broad international panel
of rheumatologists in the 3E Initiative (2011). P. Machado, I. Castrejon, W.
Katchamart, R. Koevoets, B. Kuriya, M. Schoels, L. Silva-Fernandez, K. Thevissen,
W. Vercoutere, E. Villeneuve, D. Aletaha, L. Carmona, R. Landewe, D. van der
Heijde, J. W. Bijlsma, V. Bykerk, H. Canhao, A. I. Catrina, P. Durez, C. J. Edwards,
M. D. Mjaavatten, B. F. Leeb, B. Losada, E. M. Martin-Mola, P. Martinez-Osuna, C.
Montecucco, U. Muller-Ladner, M. Ostergaard, B. Sheane, R. M. Xavier, J. Zochling
and C. Bombardier. Ann Rheum Dis, 70: 1, 15-24.
• US-guided interventional joint procedures in patients with rheumatic diseases-when and how we do it? (2011). B. Goncalves, C. Ambrosio, S. Serra, F. Alves, A.
Gil-Agostinho and F. Caseiro-Alves. Eur J Radiol, 79: 3, 407-14.
• Algorithm for identification of undifferentiated peripheral inflammatory
arthritis: a multinational collaboration through the 3e initiative (2011). G.
Hazlewood, D. Aletaha, L. Carmona, R. B. Landewe, D. M. van der Heijde, J. W.
Bijlsma, V. P. Bykerk, H. Canhao, A. I. Catrina, P. Durez, C. J. Edwards, B. F. Leeb,
M. D. Mjaavatten, P. Martinez-Osuna, C. Montecucco, M. Ostergaard, N. Serra-
Bonett, R. M. Xavier, J. Zochling, P. Machado, K. Thevissen, W. Vercoutere and C.
Bombardier. J Rheumatol Suppl, 87: 54-8.
• A stratified model for health outcomes in ankylosing spondylitis (2011). P.
Machado, R. Landewe, J. Braun, K. G. Hermann, X. Baraliakos, D. Baker, B. Hsu
and D. van der Heijde. Ann Rheum Dis, 70: 10, 1758-64.
• Ankylosing Spondylitis Disease Activity Score (ASDAS): defining cut-off
values for disease activity states and improvement scores (2011). P. Machado,
R. Landewe, E. Lie, T. K. Kvien, J. Braun, D. Baker and D. van der Heijde. Ann
Rheum Dis, 70: 1, 47-53.
• Portuguese guidelines for the use of biological agents in rheumatoid arthritis Update (2011). J. E. Fonseca, M. Bernardes, H. Canhao, M. J. Santos, A. Quintal, A.
Malcata, A. Neto, A. Cordeiro, A. Rodrigues, A. F. Mourao, A. S. Ribeiro, A. R. Cravo,
A. Barcelos, A. Cardoso, A. Vilar, A. Brana, A. Faustino, C. Silva, C. Duarte, D.
Araujo, D. Nour, E. Sousa, E. Simoes, F. Godinho, F. Brandao, F. Ventura, G.
Sequeira, G. Figueiredo, I. Cunha, J. A. Matos, J. Branco, J. Ramos, J. A. Costa, J.
A. Gomes, J. Pinto, J. C. Silva, J. A. Silva, J. V. Patto, L. Costa, L. C. Miranda, L.
Ines, L. M. Santos, M. Cruz, M. J. Salvador, M. J. Ferreira, M. Rial, M. V. Queiroz, M.
Bogas, P. Araujo, P. Reis, P. Abreu, P. Machado, P. Pinto, R. Andre, R. Melo, S.
Garces, S. Cortes, S. Alcino, S. Ramiro and S. Capela. Acta Reumatol Port, 36: 4,
385-8.
• Safety of glucocorticoids - clinical trials (2011). J. A. Da Silva. Clin Exp
Rheumatol, 29: 5 Suppl 68, S99-103.
• HLA-B27 positive patients differ from HLA-B27 negative patients in clinical
presentation and imaging: results from the DESIR cohort of patients with
recent onset axial spondyloarthritis (2011). H. Y. Chung, P. Machado, D. van der
Heijde, M. A. D'Agostino and M. Dougados. Ann Rheum Dis, 70: 11, 1930-6.
• How to measure disease activity in axial spondyloarthritis? (2011). P. Machado
and D. van der Heijde. Curr Opin Rheumatol, 23: 4, 339-45.
• The value of magnetic resonance imaging and ultrasound in undifferentiated
arthritis: a systematic review (2011). P. M. Machado, R. Koevoets, C. Bombardier
and D. M. van der Heijde. J Rheumatol Suppl, 87: 31-7.
• Endorsement of definitions of disease activity states and improvement scores
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o Revisiting the toxicity of low-dose glucocorticoids: risks and fears (2006). J. A.
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• [Tuberculosis in rheumatic patients treated with tumour necrosis factor alpha
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A. Barcelos, M. Cruz, R. A. Santos, L. Mauricio, M. Rodrigues, G. Figueiredo, A.
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• Renal amyloidosis: an uncommon complication of juvenile idiopathic arthritis
(2006). C. Duarte, C. Gomes, A. J. Correia and M. Salgado. Clin Rheumatol, 25: 4,
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• Effects of testosterone, 17beta-estradiol, and downstream estrogens on
cytokine secretion from human leukocytes in the presence and absence of
cortisol (2006). D. Janele, T. Lang, S. Capellino, M. Cutolo, J. A. Da Silva and R. H.
Straub. Ann N Y Acad Sci, 1069: 168-82.
• Safety of low dose glucocorticoid treatment in rheumatoid arthritis: published
evidence and prospective trial data (2006). J. A. Da Silva, J. W. Jacobs, J. R.
Kirwan, M. Boers, K. G. Saag, L. B. Ines, E. J. de Koning, F. Buttgereit, M. Cutolo, H.
Capell, R. Rau and J. W. Bijlsma. Ann Rheum Dis, 65: 3, 285-93.
2005
 Reumatologia Prática. (2015) JAP da Silva. Eds Diagnosteo, Coimbra
 Practical procedures in rheumatology. 2005. Guest Editors: JAP Da Silva, M
Doherty, JWJ Bijlsma. Best Practice & Research Clinical Rheumatology. 2005;
19(3).
o Developments in glucocorticoid therapy (2005). J. W. Bijlsma, K. G. Saag, F.
Buttgereit and J. A. da Silva. Rheum Dis Clin North Am, 31: 1, 1-17, vii.
o Soft tissue injections (2005). L. P. Ines and J. A. da Silva. Best Pract Res Clin
Rheumatol, 19: 3, 503-27.
• The molecular basis for the effectiveness, toxicity, and resistance to
glucocorticoids: focus on the treatment of rheumatoid arthritis (2005). F.
Buttgereit, K. G. Saag, M. Cutolo, J. A. da Silva and J. W. Bijlsma. Scand J
Rheumatol, 34: 1, 14-21.
• Problem of the month: cervical complications of rheumatoid arthritis. (2005).
Markku J Kauppi, Anabela Barcelos and JAP da Silva. Annals of the Rheumatic
Diseases 64: 355-358.
• Pivotal roles of glucocorticoids in the pathogenesis and treatment of
inflammatory rheumatic diseases. (2005). José Teles, João Eurico Fonseca, José
António Pereira da Silva. Acta Reumatológica Portuguesa 30: 27-33.
• Neuro-imuno-endocrinologia: o homem como um todo. (Editorial) (2005). JAP
da Silva. Acta Reumatológica Portuguesa 30: 295-297.
2004
• EULAR standardised operating procedures for the elaboration, evaluation,
dissemination, and implementation of recommendations endorsed by the
EULAR standing committees (2004). M. Dougados, N. Betteridge, G. R. Burmester,
L. Euller-Ziegler, F. Guillemin, J. Hirvonen, J. Lloyd, S. Ozen, J. A. Da Silva, P.
Emery, J. R. Kalden, T. Kvien, M. Matucci-Cerinic and J. Smolen. Ann Rheum Dis,
63: 9, 1172-6.
• A investigação na reumatologia portuguesa: um pouco mais de sonho e
ambição (Editorial). (2004). JAP da Silva. Acta Reumatológica Portuguesa 29: 8587.
• Indução de auto-anticorpos durante tratamento prolongado com infliximab em
doentes com artrite reumatóide. (2004). A Barcelos, MJ Salvador, JAP da Silva, A
Malcata, A Porto. Acta Reumatológica Portuguesa 29: 161-167.
2003
• Crystal associated arthropaty: a clinical exercise. (2003). Margarida A Oliveira,
JAP da Silva, Elyseo Pascual. Acta Reumatológica Portuguesa 28: 83-92.
• Imagem em “cacho de uva” da parótida 24 horas após uma sialografia. (2003).
Anabela Barcelos e JAP da Silva. Acta Reumatológica Portuguesa 28: 115-118.
• Fasciíte necrotizante e lúpus eritematoso sistémico. (2003). Anabela Barcelos,
Cândida Silva, JAP da Silva e Armando Malcata. Acta Reumatológica Portuguesa
28: 227-231.
2002
o Vasculites - tratamento. (2002). Cândida A Silva, JAP da Silva. In Reumatologia,
Mário Viana de Queiróz, Ed. Lidel, Lisboa, 2002; Vol. 2, pp 215-226.
o Differential male and female adrenal cortical steroid hormone and cortisol
responses to interleukin-6 in humans (2002). C. Silva, L. S. Ines, D. Nour, R. H.
Straub and J. A. da Silva. Ann N Y Acad Sci, 966: 68-72.
o Relationships between glucocorticoids and gonadal steroids in rheumatoid
arthritis (2002). J. A. da Silva. Ann N Y Acad Sci, 966: 158-65.
• Standardised nomenclature for glucocorticoid dosages and glucocorticoid
treatment regimens: current questions and tentative answers in rheumatology
(2002). F. Buttgereit, J. A. da Silva, M. Boers, G. R. Burmester, M. Cutolo, J. Jacobs,
J. Kirwan, L. Kohler, P. Van Riel, T. Vischer and J. W. Bijlsma. Ann Rheum Dis, 61: 8,
718-22.
• Terapêuticas biológicas em reumatologia: oportunidades terapêuticas e
imperativos éticos. (Editorial). (2002). JAP
da
Silva.
Acta
Reumatológica
Portuguesa 27: 77-78.
• Neuro-behçet: a clinical exercise. (2002). Margarida A. Oliveira, JAP da Silva,
Dolores Nour, MC Macário, A Malcata, A Porto, Aksel Siva, Hasan Yazici. Acta
Reumatológica Portuguesa 27: 157-164.
• Vacinação em doentes reumáticos. (2002). Paula Araújo, Cândida Silva, Augusto
Faustino, JAP da Silva, Armando Malcata. Acta Reumatológica Portuguesa 27: 191200.
• Radiografia das mãos: elementos típicos em artropatias comuns. (2002).
Anabela Barcelos, Dolores Nour, JAP.da Silva. Acta Reumatológica Portuguesa 27:
201-209.
• “Psico-neuro-endocrino-imuno-reumatologia”: explorando os mecanismos
biológicos das manifestações psico-somáticas. (2002). JAP
da
Silva.
Acta
2001
• Influence of sex, age, and menopausal state on the course of early rheumatoid
arthritis (2001). S. Kuiper, A. M. van Gestel, H. L. Swinkels, T. M. de Boo, J. A. da
Silva and P. L. van Riel. J Rheumatol, 28: 8, 1809-16.
• Arthropathy
of
genetic
hemochromatosis:
a
major
and
distinctive
manifestation of the disease (2001). L. S. Ines, J. A. da Silva, A. B. Malcata and A.
L. Porto. Clin Exp Rheumatol, 19: 1, 98-102.
• Novas oportunidades, novos desafios. (Editorial).(2001). A Aroso Dias e JAP da
Silva. Acta Reumatológica Portuguesa 26: 5-6.
• As doenças músculo-esqueléticas e o ensino médico. É tempo de mudar!
(editorial). (2001). JAP da Silva. Acta Reumatológica Portuguesa 26: 61-63.
• Dois irmãos com hemocromatose hereditária manifestando-se como artropatia
isolada. (2001). Luís Sousa Inês, JAP da Silva, Armando Malcata, Armando Porto.
Acta Reumatológica Portuguesa 26: 79-86.
• Fenómeno de Raynaud. Abordagem em cuidados de saúde primários. (2001).
Maria João Salvador e JAP da Silva. Acta Reumatológica Portuguesa 26: 123-130.
• Exame neurológico em reumatologia. (2001). Anabela Barcelos e JAP da Silva.
Acta Reumatológica Portuguesa 26: 201-212.
• Artralgia, febre e lesões cutâneas: Um Exercício diagnóstico. (2001). Bárbara
Fernandes, JAP da Silva, Américo Figueiredo, Armando Porto. Acta Reumatológica
• Ombro doloroso. (2001). Maria João Salvador e JAP da Silva. Acta Reumatológica
• Factor reumatóide de 36.600 U/ml. (2001). Maria João Salvador, Cândida Silva,
JAP da Silva, Armando Malcata, Armando Porto. Acta Reumatológica Portuguesa
26: 279-284.
2000
o Optimizing glucocorticoid therapy in rheumatoid arthritis (2000). J. A. Da Silva
and J. W. Bijlsma. Rheum Dis Clin North Am, 26: 4, 859-80.
• Acro-osteólise – exercício diagnóstico. (2000). Aracelli Braña, Paulo Reis, JAP da
Silva, A Malcata, A Porto. Acta Reumatológica Portuguesa 96: 52-54.
• Osteoporose na doença inflamatória intestinal. (2000). C Lérias, F Portela, JAP
da Silva. GE- Jornal Português de Gastrenterologia 2000; 7: 203-214.
• Vasculites sistémicas: a classificação condiciona a terapêutica? (2000).
Herberto Jesus e JAP da Silva. Acta Reumatológica Portuguesa 2000; 25 (99): 2735.
<2000
o Radiological progression and the outcome of rheumatoid arthritis. JAP Da
Silva, JE Dacre, DL Scott. (1991). In Trends in RA-Research, Vol. 1: Advances in
Rheumatology and Inflammation, Eds P Hedqvist e col. Eular Publishers, Basel,
1991: pp109-118.
o The effects of gender and sex hormones on outcome in rheumatoid arthritis.
JAP Da Silva, GM Hall. (1992). In The course and outcome of rheumatoid arthritis,
Ed. DL Scott, Baillière's Clinical Rheumatology 1992; 6(1): pp 193-219.
o Étude de l'effet chondrodestructeur des liquides synoviaux de polyarthrite
rhumatoide. J-P Larbre, AR Moore, JAP Da Silva, G LLorca, DA Willoughby.
(1993). In Actualités en physiopathologie et pharmacologie articulaires, Série 3, Eds:
A. Gaucher, P. Netter, J. Pourel e col, Paris, Masson, 1993: pp 163-166.
o Perturbations of the hypothalamic-pituitary-gonadal axis and adrenal androgen
functions in rheumatoid arthritis. (1996). Alfonse T Masi, JAP Da Silva,
Maurizio Cutolo. In Neuroendocrine immune mechanisms of rheumatic diseases,
Ed. I.C. Chikanza. Baillière's Clinical Rheumatology 1996; 10: pp295-332.
o Sex hormones and glucocorticoids: interactions with the immune system.
(1999). JAP Da Silva. In Neuroendocrine immune basis of the rheumatic diseases,
M Cutolo, AT Masi, JWJ Bijlsma, IC Chikanza, HL Bradlow e L Castagnetta, Eds.
Annals of The New York Academy of Sciences 1999; Vol. 876: pp 102-118.
o Gender differences in adrenal and gonadal responses to inflammatory
aggression. (1999). JAP Da Silva, Alberto Pinto, Maurizio Cutolo, Armando
Porto. In Neuroendocrine immune basis of the rheumatic diseases, Ed. M Cutolo,
AT Masi, JWJ Bijlsma, IC Chikanza, HL Bradlow e L Castagnetta. Annals of The
New York Academy of Sciences 1999; Vol. 876: pp 148-151.
 SÍndromes Paraneoplásicas. José António Pereira da Silva e Carlos Antunes
Filipe. Edição Laboratórios BIAL, 1990. Obra galardoada com o 2º lugar do Prémio
BIAL de Medicina Clínica, 1988.
• Gender differences in adrenal and gonadal responses to inflammatory
aggression (1999). J. A. Da Silva, A. Pinto, M. Cutolo and A. Porto. Ann N Y Acad
Sci, 876: 148-51.
• Sex hormones and glucocorticoids: interactions with the immune system
(1999). J. A. Da Silva. Ann N Y Acad Sci, 876: 102-17; discussion 117-8.
• Destruction of articular cartilage by alpha2 macroglobulin elastase complexes:
role in rheumatoid arthritis. (1999). AR Moore, A Appelboam, K Kawabata, JAP Da
Silva, D D'Cruz, G Gowland, DA Willoughby. Annals of the Rheumatic Diseases 58:
109-113.
• Quando referir um doente ao reumatologista? (1999). Pedro Gonçalves, JAP da
Silva. Acta Reumatológica Portuguesa 90: 21-30.
• Diagnóstico densitométrico de osteoporose: critérios de referência na
população portuguesa. (1999). JAP da Silva, Helena Carapito, Paulo Reis. Acta
• Síndrome de Sjögren com púrpura hipergamaglobulinémica, associada a
porfiria cutânea tarda e beta-talassémia minor – um caso clínico. (1999). D Nour,
C Marques, V Marques, J Silva, JAP da Silva, A Malcata, A Porto. Acta
• Poliartrite aguda com manifestações cutâneo-mucosas. (1999) Luís Sousa Inês,
JAP da Silva, A Malcata, A Porto. Acta Reumatológica Portuguesa 93: 36-37.
• Artropatia deformante familiar. (1999). Cândida Silva, JAP da Silva, A Malcata, A
Porto. Acta Reumatológica Portuguesa 95: 29-31.
• Epidemiologia e custos hospitalares das fracturas osteoporóticas do colo do
fémur nos Hospitais da Universidade de Coimbra. (1998). L Sousa Inês, JAP da
Silva, N Canha e Armando Porto. Acta Reumatológica Portuguesa 84: 7-18.
• POLIARTRITE E DERMATOSE NEUTROFÍLICA. (1998). L. Sousa Inês, Bárbara
Fernandes, JAP.da Silva, M Gonçalo, A Malcata e Armando Porto. Acta
Reumatológica Portuguesa 1998; 87: 163-169.
• Sex hormones and osteoporosis: a physiological perspective for prevention
and therapy. (1997). J. A. da Silva and A. Porto. Acta Med Port, 10: 10, 689-95.
• Reumatologia: a qualidade de formação e o futuro. (editorial). (1997). JAP da
Silva e Jaime C. Branco. Acta Reumatológica Portuguesa 80: 6-7.
• A randomized trial of testosterone therapy in males with rheumatoid arthritis
(1996). G. M. Hall, J. P. Larbre, T. D. Spector, L. A. Perry and J. A. Da Silva. Br J
Rheumatol, 35: 6, 568-73.
• Sex hormones, glucocorticoids and autoimmunity. Facts and hypotheses.
(1995). JAP Da Silva. Annals of the Rheumatic Diseases 54: 6-16.
• Nefrite lúpica: o papel da biópsia. Contribuições para um debate inacabado.
(1995). JAP da Silva, Armando Malcata, Armando Porto. Acta Reumatológica
• Sex differences in inflammation-induced cartilage damage in rodents. The
influence of sex steroids. (1994). JAP Da Silva, J-P Larbre, MP Seed, M Cutolo, B
Villagio, DL Scott, DA Willoughby. Journal of Rheumatology 21: 330-337.
• Cartilage contribution to gender differences in joint disease progression. A
study with rat articular cartilage. (1994). J-P Larbre, JAP Da Silva, AR Moore, IT
James, DL Scott, DA Willoughby. Clinical and Experimental Rheumatology 12: 401408.
• Direct degradation of articular cartilage by rheumatoid synovial fluid:
contribution of proteolytic enzymes. (1994). J-P Larbre, AR Moore, JAP Da Silva,
H. Iwamura, Y. Ioannou, DA Willoughby. Journal of Rheumatology 21: 1796-1801.
• Ensino médico: desafios para o futuro. (1994). JAP da Silva, Dick Martenson e
Armando Porto. Acta Médica Portuguesa 7: 639-646.
• The influence of sex in arthritis: is cartilage an overlooked factor? (1994). J. A.
Da Silva and D. A. Willoughby. J Rheumatol, 21: 5, 791-6.
• Efficacy of a single daily dose of a nonsteroidal anti-inflammatory drug with an
intermediate plasma half-life: A double-blind, comparative trial of acemetacin
and piroxicam (1993). F. Teixeira, A. Porto and J. Moura. Current Therapeutic
Research, 53: 1, 103-112.
• The role of pregnancy in the course and aetiology of rheumatoid arthritis.
(1992). JAP Da Silva, TD Spector. Clinical Rheumatology 11: 189-194.
• Pregnancy and rheumatoid arthritis: an overview. (1992). Spector TD e JAP Da
Silva JAP. American Journal of Reproductive Immunology 28: 222-225.
• Heat shock proteins: the missing link between hormonal and reproductive
factors and rheumatoid arthritis? (1991). J. A. da Silva. Ann Rheum Dis, 50: 10,
735-9.
• Joint space in radiologically normal knees (1991). JE Dacre, DL Scott, JAP Da
Silva, G Welsh, EC Huskisson. British Journal of Rheumatology 30: 426-428.
• Sex steroids affect glucocorticoid response to chronic
inflammation and to
interleukin-1. (1993) JAP Da Silva, SH Peers, M Perretti, DA Willoughby. Journal of
Endocrinology 136: 389-397.
• Protective effects of androgens against inflammation-induced cartilage
degradation in male rodents. (1993). JAP Da Silva, J-P Larbre, TD Spector, LA
Perry, DL Scott, DA Willoughby. Annals of the Rheumatic Diseases 52: 285-291.
• Inflammation-induced cartilage degradation in female rodents: protective role
of sex hormones. (1993). JAP Da Silva, P Colville-Nash, TD Spector, DL Scott, DA
Willoughby. Arthritis and Rheumatism 36: 1007-1013.

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