Unerwünschte kardiovaskuläre Wirkungen von Psychopharmaka
Transcrição
Unerwünschte kardiovaskuläre Wirkungen von Psychopharmaka
Übersicht AMT Unerwünschte kardiovaskuläre Wirkungen von Psychopharmaka Pathophysiologie und Risikominimierung Katharina Wenzel-Seifert, Regensburg, Claus-Peter Ostermeier, Werneck, Nagia Ben Omar und Ekkehard Haen, Regensburg, für die Arbeitsgemeinschaft Arzneimitteltherapie bei psychiatrischen Erkrankungen (AGATE e. V.) Literatur 1. Agus ZS. Hypomagnesemia. J Am Soc Nephrol 1999;10:616–22. 2. Alvarez P, Pahissa J. QT alterations in psychopharmacology: proven candidates and suspects. Curr Drug Saf 2010;5:97–104. 3. Antzelevitch C. Ionic, molecular, and cellular bases of QT-interval prolongation and torsade de pointes. Europace 2007;9(Suppl 4):iv4–15. Epub 2007 Nov 21. 4. Arizona CERT. QT Drug Lists by Risk Groups. http://www.azcert.org/medical-pros/drug-lists/drug-lists.cfm (Zugriff am 15.06.2013). 5. Arzneimittelkommission der Deutschen Ärzteschaft. Information über die Änderung der bisher empfohlenen Applikationswege von Haldol®Janssen Injektionslösung. AkdÄ Drug Safety Mail 2010. http://www. akdae.de/Arzneimittelsicherheit/DSM/Archiv/2010-098.html (Zugriff am 15.06.2013). 6. Astrom-Lilja C, Odeberg JM, Ekman E, Hägg S. Drug-induced torsades de pointes: a review of the Swedish pharmacovigilance database. Pharmacoepidemiol Drug Saf 2008;17:587–92. 7. Azene EM, Xue T, Li RA. Molecular basis of the effect of potassium on heterologously expressed pacemaker (HCN) channels. J Physiol 2003;547:349–56. Epub 2003 Feb 04. 8. Banov M, Tohen M, Friedberg J. High risk of eosinophilia in women treated with clozapine. J Clin Psychiatry 1995;54:466–9. 9. Barak Y, Swartz M, Levy D, Weizman R. Age-related differences in the side effect profile of citalopram. Prog Neuropsychopharmacol Biol Psychiatry 2003;27:545–8. Epub 2003 Apr 15. 10.Berkelhammer C, Bear R. A clinical approach to commen electrolyte problems: 4. Hypomagnesemia. Can Med Assoc J 1985;132:360–8. 11.Beyenburg S, Schonegger K. Severe bradycardia in a stroke patient caused by a single low dose of escitalopram. Eur Neurol 2007;57:50–1. Epub 2006 Nov 23. 12.Bogdanov KY, Vinogradova TM, Lakatta EG. Sinoatrial nodal cell ryanodine receptor and Na+-Ca2+ exchanger: molecular partners in pacemaker regulation. Circ Res 2001;88:1254–8. Epub 2001 Jun 23. 13.Butany J, Ahn E, Luk A. Drug-related cardiac pathology. J Clin Pathol 2009;62:1074–84. Epub 2009 Dez 01. 14.Carnahan RM, Lund BC, Perry PJ, Pollock BG, et al. The anticholinergic drug scale as a measure of drug-related anticholinergic burden: associations with serum anticholinergic activity. J Clin Pharmacol 2006;46:1481–6. Epub 2006 Nov 15. 15.Castro VM, Clements CC, Murphy SN, Gainer VS, et al. QT interval and antidepressant use: a cross sectional study of electronic health records. BMJ 2013;346:f288. DOI: 10.1136/bmj.f288. Epub 2013 Jan 31. 16.Chew ML, Mulsant BH, Pollock BG, Lehman ME, et al. Anticholinergic activity of 107 medications commonly used by older adults. J Am Geriatr Soc 2008;56:1333–41. Epub 2008 May 31. 17.Cohn J, Kowey P, Whelton P, Prisant L. New guidelines for potassium replacement in clinical practice. A contemperary review by the national council on potassium in clinical practice. Arch Int Med 2000;160:2429– 36. 18.Couderc JP, Xiaojuan X, Zareba W, Moss AJ. Assessment of the stability of the individual-based correction of QT interval for heart rate. Ann Noninvasive Electrocardiol 2005;10:25–34. Epub 2005 Jan 15. 19.Coulter D, Bate A, Mayboom R, Lindquist M, et al. Antipsychotic drugs and heart muscle disorder in international parmacovigilance: data min ing study. BMJ 2001;62:191–8. 20.DePonti F, Poluzzi E, Montanaro N. Organising evidence on QT prolongation and occurrence of torsades de pointes with non-anti-arrhythmic drugs: a call for consensus. Eur J Clin Pharmacol 2001;57:185–209. 21.Druteika D, Zed PJ. Cardiotoxicity following bupropion overdose. Ann Pharmacother 2002;36:1791–5. Epub 2002 Oct 26. 22.Eap CB, Crettol S, Rougier JS, Schlapfer J, et al. Stereoselective block of hERG channel by (S)-methadone and QT interval prolongation in CYP2B6 slow metabolizers. Clin Pharmacol Ther 2007;81:719–28. Epub 2007 Mar 03. 23.Eckhardt LL, Rajamani S, January CT. Protein trafficking abnormalities: a new mechanism in drug-induced long QT syndrome. Br J Pharmacol 2005;145:3–4. Epub 2005 Feb 16. 24.FDA. Information for Healthcare Professionals: Haloperidol (marketed as Haldol, Haldol Decanoate and Haldol Lactate). FDA ALERT 9/2007. http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/DrugSafetyInformationforHeathcareProfessionals/ucm085203.htm. (Zugriff am 15.06.2013). 25.FDA. FDA Drug Safety Communication: Abnormal heart rhythms associated with high doses of Celax® (citalopram hydrochloride). FDA Drug Safety Communication 24.8.2011.http://www.fda.gov/Drugs/DrugSafety/ ucm269086.htm (Zugriff am 15.06.2013). 26.FDA. Stimulant medications used in children with attention-deficit/hyperactivity disorder – Communication about an ongoing review. FDA drug safety communications 12.12.2011. http://www.fda.gov/Drugs/ DrugSafety/ucm277770.htm. (Zugriff am 15.06.2013). 27.FDA. Safety review of medications used to treat attention-deficit/hyperactivity disorder (ADHD) in adults. FDA drug safety communications 12.12.2011. http://www.fda.gov/Drugs/DrugSafety/ucm277770.htm (Zugriff am 15.06.2013). 28.FDA Center for Drug Evaluation and Research. Approval package for Celexa: Interdisciplinary Review Team for QT Studies Consultation: Thorough QT Study Review. 12. August 2011. S. 77–104. http://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/020822Orig1s038s040_021046Or ig1s016s017Rev.pdf [77–104] (Zugriff am 15.06.2013). 29.Feinstein RE. Cardiovascular effects of novel antipsychotic medications. Heart Dis 2002;4:184–90. Epub 2002 May 25. 30.Florian J, Garnett CE, Nallani SC, Rappaport BA, et al. A modeling and simulation approach to characterize methadone QT prolongation using pooled data from five clinical trials in MMT patients. Clin Pharmacol Ther 2012;91:666–72. Epub 2012 Mar 02. 31.Goodnick PJ, Jerry J, Parra F. Psychotropic drugs and the ECG: focus on the QTc interval. Experts Opin Pharmacother 2002;3:479–98. 32.Haas SJ, Hill R, Krum H, Liew D, et al. Clozapine-associated myocarditis: a review of 116 cases of suspected myocarditis associated with the use of clozapine in Australia during 1993–2003. Drug Saf 2007;30:47–57. Epub 2006 Dec 30. 33.Haddad P, Anderson I. Antipsychotic-related QTc prolongation, torsade de pointes and sudden death. Drugs 2002;62:1649–71. 34.Haverkamp H, Deuschle M. Antipsychotikainduzierte QT-Verlängerung. Nervenarzt 2006;77:276–88. Dr. med. Katharina Wenzel-Seifert, Nagia Ben Omar, Prof. Dr. med. Dr. rer. nat. Ekkehard Haen, Klinische Pharmakologie am Lehrstuhl mit Poliklinik für Psychiatrie und Psychotherapie der Universität Regensburg, Universitätsstraße 84, 93053 Regensburg, E‑Mail: [email protected] Claus-Peter Ostermeier, Krankenhaus für Psychiatrie, Psychotherapie und Psychosomatische Medizin Schloss Werneck, Balthasar-Neumann-Platz 1, 97440 Werneck Arzneimitteltherapie 31. Jahrgang · Heft 11 · 2013 *1 AMT Übersicht 35.Hiemke C, Bauman P, Bergemann N, Conca A, et al. AGNP-KonsensusLeitlinien für therapeutisches Drug-Monitoring in der Psychiatrie: Update 2011. Psychopharmakotherapie 2012;19:91–122. 36.Hoffmann P, Warner B. Are hERG-channel inhibition and QT interval prolongation all there is in drug-induced torsadogenesis? A review of emerging trends. J Pharmacol Toxicol Methods 2006;53:87–105. Epub Date 2005 Nov 18. 37.Howell C, Wilson AD, Waring WS. Cardiovascular toxicity due to venlafaxine poisoning in adults: a review of 235 consecutive cases. B J Clin Pharmacol 2007;64:192–7. Epub 2007 Feb 15. 38.Hsu C, Liu P, Chen J, Yeh T, et al. Electrocardiographic abnormalities as predictors for over-range lithium levels. Cardiology 2005;103:101–6. 39.Ide A, Kamijo Y. Intermittent complete atrioventricular block after long term low-dose carbamazepine therapy with a serum concentration less than the therapeutic level. Intern Med 2007;46:627–9. Epub 2007 May 03. 40.Iqbal M, Rahman A, Husain Z, Mahmud S, et al. Clozapine: A clinical review of adverse effects and management. Ann Clin Psychiatry 2003;15:33–48. 41.Justo D, Prokhorov V, Heller K, Zeltser D. Torsade de pointes induced by psychotropic drugs and the prevalence of its risk factors. Acta Psychiat Scand 2005;111:171–6. Epub 2005 Feb 11. 42.Kandan SR, Saha M. Severe primary hypothyroidism presenting with torsades de pointes. BMJ Case Rep 2012; DOI: 10.1136/bcr.12.2011.5306. Epub 2012 Sep 19. 43.Kiev A, Masco HL, Wenger TL, Johnston JA, et al. The cardiovascular effects of bupropion and nortriptyline in depressed outpatients. Ann Clin Psychiatry 1994;6:107–15. Epub 1994 Jun 01. 44.Killian J, Kerr R, Lawrence C, Celermajer D. Myocarditis and cardiomyopathy with clozapine. Lancet 1999;354:1841–5. 45.Kleinfeld M, Borra S, Gavani S, Corcoran A. Hypokalemia: Are elderly females more vulnerable? J Natl Med Assoc 1993;85:861–4. 46.Krantz MJ, Lewkowiez L, Hays H, Woodroffe MA, et al. Torsade de pointes associated with very-high-dose methadone. Ann Intern Med 2002;137:501–4. Epub 2002 Sep 17. 47.Leung JYT, Barra AM, Procyshynb RM, Honerb WG, et al. Cardiovascular side-effects of antipsychotic drugs: The role of the autonomic nervous system. Pharmacol Ther 2012;135:113–22. 48.Lilly Deutschland GmbH. Risiko eines Blutdruck- und Herzfrequenzanstiegs. Rote-Hand-Brief zu Strattera® (Atomoxetin) 07.12.2011. www. bfarm.de/DE/Pharmakovigilanz/risikoinfo/2011/rhb-strattera.html (Zugriff am 15.06.2013). 49.Lockhart IA, Mitchell SA, Kelly S. Safety and tolerability of donepezil, rivastigmine and galantamine for patients with Alzheimer’s disease: systematic review of the „real-world“ evidence. Dement Geriatr Cogn Disord 2009;28:389–403. Epub 2009 Nov 07. 50.Lundbeck GmbH. Zusammenhang von Escitalopram (Cipralex®) mit dosisabhängiger QT-Intervall-Verlängerung. Rote-Hand-Brief zu Escitalopram (Cipralex®) 5. Oktober 2011. http://www.bfarm.de/DE/Pharmakovigilanz/risikoinfo/Archiv/2011/rhb-cipralex.html (Zugriff am 15.06.2013). 51.Lundbeck GmbH. Zusammenhang von Cipramil® (Citalopramhydrobromid /Citalopramhydrochlorid) mit dosisabhängiger QT-Intervallverlängerung. Rote-Hand-Brief zu Cipramil® (Citalopram). 31. Oktober 2011. http://www.bfarm.de/DE/Pharmakovigilanz/risikoinfo/Archiv/2011/rhbcipramil.html (Zugriff am 15.06.2013). 52.Mackin P. Cardiac side effects of psychiatric drugs. Human Psychopharmacol Clin Exp 2008;23:3–14. 53.Mayet S, Gossop M, Lintzeris N, Markides V, et al. Methadone maintenance, QTc and torsade de pointes: who needs an electrocardiogram and what is the prevalence of QTc prolongation? Drug Alcohol Rev 2011;30:388–96. Epub 2011 Maerz 02. 54.McKnight RF, Adida M, Budge K, Stockton S, et al. Lithium toxicity profile: a systematic review and meta-analysis. Lancet 2012;379:721–8. Epub 2012 Jan 24. 55.Merrill D, Dec G, Goff D. Adverse cardiac effects associated with clozapine. J Clin Psychopharmacol 2005;25:32–41. 56.Meyer-Massetti C, Cheng CM, Sharpe BA, Meier CR, et al. The FDA extended warning for intravenous haloperidol and torsades de pointes: how should institutions respond? J Hosp Med 2010;5:E8–16. Epub 2010 Apr 16. 57.Mitcheson JS. hERG potassium channels and the structural basis of druginduced arrhythmias. Chem Res Toxicol 2008;21:1005–10. Epub 2008 May 02. 58.Novartis. Association of Clozaril (clozapine) with cardiovasculr toxicity. Dear Healthcare Professional Letter. 14.01.2002. http://www.canadiensensante.gc.ca/recall-alert-rappel-avis/hc-sc/2002/14697a-eng.php (Zugriff am 15.06.2013). 59.Offerman SR, Alsop JA, Lee J, Holmes JF. Hospitalized lithium overdose cases reported to the California Poison Control System. Clin Toxicol 2010;48:443–8. Epub 2010 Jun 03. *2 Arzneimitteltherapie 31. Jahrgang · Heft 11 · 2013 60.Oka H, Yoshioka M, Onouchi K, Morita M, et al. Characteristics of orthostatic hypotension in Parkinson’s disease. Brain 2007;130:2425–32. 61.Oudit GY, Korley V, Backx PH, Dorian P. Lithium-induced sinus node disease at therapeutic concentrations: linking lithium-induced block ade of sodium channels to impaired pacemaker activity. Can J Cardiol 2007;23:229–32. Epub 2007 Mar 10. 62.Ozeki Y, Fujii K, Kurimoto N, Yamada N, et al. QTc prolongation and antipsychotic medications in a sample of 1,017 patients with schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 2010;34:401–5. 63.Pacher P, Kecskemeti V. Cardiovascular side effects of new antidepressants and antipsychotics: New drugs, old concerns? Curr Pharm Des 2004;10:2463–75. 64.Peterson K, McDonagh MS, Fu R. Comparative benefits and harms of competing medications for adults with attention-deficit hyperactivity disorder: a systematic review and indirect comparison meta-analysis. Psychopharmacology 2008;197:1–11. Epub 2007 Nov 21. 65.Poluzzi E, Raschi E, Moretti U, De Ponti F. Drug-induced torsades de pointes: data mining of the public version of the FDA Adverse Event Reporting System (AERS). Pharmacoepidemiol Drug Saf 2009;18:512–8. 66.Priori SG, Aliot E, Blomstrom-Lundqvist C, Bossaert L, et al. Task Force on Sudden Cardiac Death, European Society of Cardiology. Europace 2002;4:3–18. 67.Rajamani S, Eckhardt LL, Valdivia CR, Klemens CA, et al. Drug-induced long QT syndrome: hERG K+ channel block and disruption of protein trafficking by fluoxetine and norfluoxetine. Br J Pharmacol 2006;149:481–9. Epub 2006 Sep 13. 68.Rastergar A, Soleimani M. Hypokalaemia and hyperkalaemia. Postgrad Med J 2001;77:759–64. 69.Reddy S, Hui D, El Osta B, de la Cruz M, et al. The effect of oral metha done on the QTc interval in advanced cancer patients: a prospective pilot study. J Palliat Med 2010;13:33–8. 70.Roesch-Ely D, Van Einsiedel R, Kathofer S, Schwaninger M, et al. Myocarditis with quetiapine. Am J Psychiatry 2002;159:1607–8. 71.Roose SP, Glassman AH, Giardina EG, Walsh BT, et al. Tricyclic antidepressants in depressed patients with cardiac conduction disease. Arch Gen Psychiatry 1987;44:273–5. Epub 1987 Mar 01. 72.Roose SP, Dalack GW, Glassman AH, Woodring S, et al. Cardiovascular effects of bupropion in depressed patients with heart disease. Am J Psychiatry 1991;148:512–6. Epub 1991 Apr 01. 73.Sala M, Vicentini A, Brambilla P, Montomoli C, et al. QT interval prolongation related to psychoactive drug treatment: a comparison of monotherapy versus polytherapy. Ann Gen Psychiatry 2005;4:1. DOI:10.1186/1744–859X-4–1, 74.Schömig H, Ritz E, Stein G. Elektrolyt- und Wasserhaushalt. In: Berdel W, Böhm M, Classen M, Diehl V, et al. (Hrsg.). Innere Medizin. 5. Auflage. München: Urban & Fischer, 2004: 1729–63. 75.Sharma ND, Rosman HS, Padhi ID, Tisdale JE. Torsades de pointes associated with intravenous haloperidol in critically ill patients. Am J Cardiol 1998;81:238–40. 76.Shojaie M, Eshraghian A. Primary hypothyroidism presenting with Torsades de pointes type tachycardia: a case report. Cases J 2008;1:298. Epub 2008 Nov 08. 77.Siebrands CC, Schmitt N, Friederich P. Local anesthetic interaction with human ether-a-go-go-related gene (HERG) channels: role of aromatic amino acids Y652 and F656. Anesthesiology 2005;103:102–12. Epub 2005 Jun 29. 78.Spallone V, Ziegler D, Freeman R, Bernardi L, et al. Cardiovascular autonomic neuropathy in diabetes: clinical impact, assessment, diagnosis, and management. Diabetes Metab Res Rev 2011 Jun 23, doi: 10.1002/ dmrr.1239. 79.Spigset O. Adverse reactions of selective serotonin reuptake inhibitors: reports from a spontaneous reporting system. Drug Saf 1999;20:277–87. Epub 1999 Apr 30. 80.Stahl SM, Grady MM, Moret C, Briley M. SNRIs: their pharmacology, clinical efficacy, and tolerability in comparison with other classes of antidepressants. CNS Spectr 2005;10:732–47. Epub 2005 Sep 06. 81.Stallvik M, Nordstrand B, Kristensen O, Bathen J, et al. Corrected QT interval during treatment with methadone and buprenorphine – relation to doses and serum concentrations. Drug Alcohol Depend 2013;129:88– 93. Epub 2012 Oct 23. 82.Sterke CS, Ziere G, van Beeck EF, Looman CW, et al. Dose-response relationship between selective serotonin re-uptake inhibitors and injurious falls: a study in nursing home residents with dementia. B J Clin Pharmacol 2012;73:812–20. 83.Stöllberger C, Huber JO, Finsterer J. Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacology 2005;20:243–51. 84.Straus SM, Bleumink GS, Dieleman JP, van der Lei J, et al. Antipsychotics and the risk of sudden cardiac death. Arch Intern Med 2004;164:1293–7. Epub 2004 Jul 01. Unerwünschte kardiovaskuläre Wirkungen von Psychopharmaka AMT 85.Talati SN, Aslam AF, Vasavada B. Sinus node dysfunction in association with chronic lithium therapy: a case report and review of literature. Am J Ther 2009;16:274–8. Epub 2009 Apr 09. 86.Tank J, Schroeder C, Diedrich A, Szczech E, et al. Selective impairment in sympathetic vasomotor control with norepinephrine transporter inhibition. Circulation 2003;107:2949–54. Epub 2003 Jun 11. 87.Thanacoody HK, Thomas SH. Tricyclic antidepressant poisoning: cardiovascular toxicity. Toxicol Rev 2005;24:205–14. Epub 2006 Jan 05. 88.van Melick EJ, Wilting I, Meinders AE, Egberts TC. Prevalence and determinants of thyroid disorders in elderly patients with affective disorders: lithium and nonlithium patients. Am J Geriatric Psychiatry 2010;18:395–403. Epub 2010 Apr 30. 89.van Noord C, Straus S, Sturkenboom M, Hofman A, et al. Psychotropic drugs associated with corrected QT interval prolongation. J Clin Psychopharmacol 2009;29:9–15. 90.Vieweg WV, Wood MA, Fernandez A, Beatty-Brooks M, et al. Proarrhythmic risk with antipsychotic and antidepressant drugs: implications in the elderly. Drugs Aging 2009;26:997–1012. Epub 2009 Nov 26. 91.Warner B, Hoffmann P. Investigation of the potential of clozapine to cause torsade de pointes. Adverse Drug React Toxicol Rev 2002;21:189– 203. 92.Weeke P, Jensen A, Folke F, Gislason GH, et al. Antidepressant use and risk of out-of-hospital cardiac arrest: a nationwide case-time-control study. Clin Pharmacol Ther 2012;92:72–9. Epub 2012 May 17. 93.Weiner I, Wingo C. Hypokalemia – Consequences, causes, and correction. J Am Soc Nephrol 1997;8:179–88. 94.Wenzel-Seifert K, Haen E. Rote-Hand-Briefe zu Citalopram und Escitalo pram. Psychopharmakotherapie 2012;19:19–21. 95.Wenzel-Seifert K, Haen E. Kardiovaskuläres Risiko bei medikamentöser ADHS-Behandlung. Psychopharmakotherapie 2013: im Druck. 96.Wenzel-Seifert K, Wittmann M, Haen E. Psychopharmakaassoziierte QTc-Intervall-Verlängerung und Torsade de pointes. Dtsch Ärztebl 2011;108:687–93. 97.Wernicke J, Faries D, Girod D, Brown J, et al. Cardiovascular effects of atomoxetine in children, adolescents, and adults. Drug Saf 2003;26:729– 40. 98.Wernicke J, Raskin J, Kajdasz DK, Wang F. An evaluation of the cardiovascular safety profile of duloxetine: findings from 42 placebo-controlled studies. Drug Saf 2007;30:437–55. Arzneimitteltherapie 31. Jahrgang · Heft 11 · 2013 *3