Karl Kunzelmann Publications (March 1987

Karl Kunzelmann Publications (March 1987

Karl Kunzelmann
Publications (March 1987 - April 2015)
A) Original publications
1.
Hayslett,J.P., H.Gögelein, K.Kunzelmann, and R.Greger. (1987) Characteristics of apical
chloride channels in human colon cells (HT29). Pflügers Arch 410:487-494
----------------------------------------------------------------------------------------------------------------------------2. Kunzelmann,K., H.Pavenstädt, and R.Greger.(1989) Characterization of potassium
channels in respiratory cells II. Inhibitors and Regulation. Pflügers Arch 414:297-303
3.
Kunzelmann,K., H.Pavenstädt, C.Beck, Ö.Ünal, P.Emmrich, H.J.Arndt, and
R.Greger.(1989) Characterization of potassium channels in respiratory cells I. General
properties. Pflügers Arch 414:291-296
4.
Kunzelmann,K., H.Pavenstädt, and R.Greger.(1989) Properties and regulation of chloride
channels in cystic fibrosis and normal airway epithelial cells. Pflügers Arch 415:172-182
----------------------------------------------------------------------------------------------------------------------------5. Greger,R. and K.Kunzelmann.(1991) Simultaneous recording of the cell membrane
potential and properties of the cell attached membrane of HT29 colon carcinoma and CFPAC cells. Pflügers Arch 419:209-211
6.
Kunzelmann,K., M.Tilmann, C.P.Hansen, and R.Greger.(1991) Inhibition of epithelial
chloride channels by cytosol. Pflügers Arch 418:479-490
7.
Kunzelmann,K., L.Gerlach, U.Fröbe, and R.Greger.(1991) Bicarbonate permeability of
epithelial chloride channels. Pflügers Arch 417:616-621
8.
Pavenstädt,H., V.Lindeman, S.Lindeman, K.Kunzelmann, M.Späth, and R.Greger.(1991)
Effect of depolarizing and hyperpolarizing agents on the membrane potential difference
of primary cultures of rabbit aorta vascular smooth muscle cells. Pflügers Arch 419:69-75
9.
Pavenstädt,H., S.Lindeman, V.Lindeman, M.Späth, K.Kunzelmann, and R.Greger.(1991)
Potassium conductance of smooth muscle cells from rabbit aorta in primary culture.
Pflügers Arch 419:57-68
10.
Tilmann,M., K.Kunzelmann, U.Fröbe, Z.I.Cabantchik, H.-J.Lang, H.C.Englert, and
R.Greger.(1991) Different types of blockers of the intermediate conductance outwardly
rectifying chloride channel (ICOR) in epithelia. Pflügers Arch 418:556-563
----------------------------------------------------------------------------------------------------------------------------11. Kubitz,R., R.Warth, K.Kunzelmann, M.Grolik, and R.Greger.(1992) Small conductance
Cl- channels induced by cAMP, Ca2+, and hypotonicity in HT29 cells: ion selectivity,
additivity and stilbene sensitivity. Pflügers Arch 421:447-454
12.
Kunzelmann,K., R.Kubitz, M.Grolik, R.Warth, and R.Greger.(1992) Small conductance
Cl- channels in HT29 cells: activation by Ca2+, hypotonic cell swelling and 8-Br-cGMP.
Pflügers Arch 421:238-246
13.
Kunzelmann,K., M.Grolik, R.Kubitz, and R.Greger.(1992) cAMP dependent activation of
small conductance Cl- channels in HT29 colon carcinoma cells. Pflügers Arch 421:230237
----------------------------------------------------------------------------------------------------------------------------14. Hansen,C.P., B.Roch, K.Kunzelmann, R.Kubitz, and R.Greger.(1993) Small and
intermediate conductance chloride channels in HT29 cells. Pflügers Arch 424:456-464
15.
Kunzelmann,K., E.M.Schwiebert, W.-L.Kuo, B.A.Stanton, and D.C.Gruenert.(1993) An
immortalized cystic fibrosis tracheal epithelial cell line homozygous for the deltaF508
CFTR mutation. Am J Respir Cell Molec Biol 8:522-529
----------------------------------------------------------------------------------------------------------------------------16. Cozens,A.L., M.J.Yezzi, K.Kunzelmann, T.Ohrui, L.Chin, K.Eng, W.E.Finkbeiner,
J.H.Widdicombe, and D.C.Gruenert.(1994) CFTR expression and chloride secretion in
polarized immortal human bronchial epithelial cells. American J Respir Cell Molec Biol
10:38-47
17.
Koslowsky,T.,
T.Hug,
D.Ecke,
P.Klein,
R.Greger,
D.C.Gruenert,
and
K.Kunzelmann.(1994) Ca2+ and swelling induced activation of ion conductances in
bronchial epithelial cells. Pflügers Arch 428:597-603
18.
Kunzelmann,K., T.Koslowsky, D.C.Gruenert, and R.Greger.(1994) CAMP-dependent
activation of ion conductances in bronchial epithelial cells. Pflügers Arch 428:590-596
19.
Kunzelmann,K., I.N.Slotki, P.Klein, T.Koslowsky, D.A.Ausiello, R.Greger, and
Z.I.Cabantchik.(1994) Effects of P-glycoprotein expression on cyclic AMP and volume
activated ion fluxes and conductances in HT29 colon carcinoma cells. J.Cell.Physiol.
161:393-406
20.
Kunzelmann,K., N.Allert, R.Kubitz, W.V.Breuer, Z.I.Cabantchik, C.Normann,
S.Schumann, J.Leipziger, and R.Greger.(1994) Forskolin- and PMA-pretreatment alter
the acute electrical response of HT29 cells to cAMP, ATP, neurotensin, ionomycin and
hypotonic cell swelling. Pflügers Arch 428:76-83
----------------------------------------------------------------------------------------------------------------------------21. Hipper,A., M.Mall, R.Greger, and K.Kunzelmann.(1995) Mutations in the putative pore
forming domain of CFTR do not change anion selectivity of the cAMP activated Clconductance. FEBS Letters 374:312-316
22.
Hug,T., T.Koslowsky, D.Ecke, R.Greger, and K.Kunzelmann.(1995) Actin-dependent
activation of ion conductances in bronchial epithelial cells. Pflügers Arch 429:682-690
23.
Krick,W., J.Disser, A.Rabe, E.Frömter, C.P.Hansen, B.Roch, K.Kunzelmann, R.Greger,
W.Fehlhaber, and G.Burckhardt.(1995) Characterization of cytosolic Cl- channel inhibitors
by size exclusion chromatography. Cell Physiol Biochem 5:259-268
24.
Kunzelmann,K., S.Kathöfer, and R.Greger.(1995) Na+ and Cl- conductances in airway
epithelial cells: Increased Na+ conductance in cystic fibrosis. Pflügers Arch 431:1-9
25.
Lei,D.C., K.Kunzelmann, T.Koslowsky, M.J.Yezzi, L.C.Escobar, Z.D.Xu, J.M.Rommens,
L.-C.Tsui, M.Tykocinski, and D.C.Gruenert.(1995) Episomal expression of wilde-type
CFTR corrects cAMP-dependent chloride transport in respiratory epithelial cells. Gene
Therapy 3:427-436
----------------------------------------------------------------------------------------------------------------------------2
26.
Busch,A.E., H.Süssbrich, K.Kunzelmann, A.Hipper, R.Greger, S.Waldegger,
E.Mutschler, B.Lindemann, and F.Lang.(1996) Blockade of epithelial Na+ channels by
triamterens-underlying mechanisms and molecular basis. Pflügers Arch 432:760-766
27.
Busch,A.E., H.G.Kopp, S.Waldegger, I.Samarzija, H.Süssbrich, G.Raber, K.Kunzelmann,
J.P.Ruppersberg, and F.Lang.(1996) Effects of isosorbiddinitrate on exogenously
expressed slowly activating K+ channels and endogenous K+ channels in Xenopus
oocytes. J.Physiol. 491:735-741
28.
Greger,R., M.Mall, M.Bleich, D.Ecke, R.Warth, N.Riedemann, and K.Kunzelmann.(1996)
Regulation of epithelial ion channels by the cystic fibrosis transmembrane conductance
regulator (CFTR). J Mol Med 74:527-534
29.
Köttgen,M., A.E.Busch, M.J.Hug, R.Greger, and K.Kunzelmann.(1996) N-acetyl-Lcysteine and derivatives activate Cl- conductances in epithelial cells. Pflügers Arch
431:549-555
30.
Kunzelmann,K., J.-Y.Legendre, D.L.Knoell, L.C.Escobar, Z.Xu, and D.C.Gruenert.(1996)
Gene targeting of CFTR DNA in CF epithelial cells. Gene Therapy 3:859-867
31.
Kunzelmann,K., S.Kathöfer, A.Hipper, D.C.Gruenert, and R.Greger.(1996) Culturedependent expression of Na+ conductances in airway epithelial cells. Pflügers Arch
431:578-586
32.
Mall,M., K.Kunzelmann, A.Hipper, A.E.Busch, and R.Greger.(1996) cAMP stimulation of
CFTR expressing Xenopus oocytes activates a chromanol inhibitable K+ conductance.
Pflügers Arch 432:516-522
33.
Mall,M., A.Hipper, R.Greger, and K.Kunzelmann.(1996) Wild type but not deltaF508
CFTR inhibits Na+ conductance when coexpressed in Xenopus oocytes. FEBS Letters
381:47-52
34.
Süssbrich,H., M.Bleich, D.Ecke, M.Rizzo, S.Waldegger, F.Lang, I.Szabo, H.-J.Lang,
K.Kunzelmann, R.Greger, and A.E.Busch.(1996) Specific blockade of slowly activating
IsK channels by chromanols-impact on the role of IsK channels in epithelia. FEBS Letters
396:271-275
----------------------------------------------------------------------------------------------------------------------------35. Bleich,M.,
M.Briel,
A.E.Busch,
H.-J.Lang,
U.Gerlach,
R.Greger,
and
K.Kunzelmann.(1997) KVLQT channels are inhibited by the K+ channel blocker 293B.
Pflügers Arch 434:499-501
36.
Busch,A.E., G.L.Busch, E.Ford, H.Suessbrich, H.J.Lang, R.Greger, K.Kunzelmann,
B.Attali, and W.Stühmer.(1997) The role of the IsK protein in the specific
pharmacological properties of the IKs channel complex. Br.J.Pharmacol. 122:187-189
37.
Kunzelmann,K., M.Mall, M.Briel, A.Hipper, R.Nitschke, S.Ricken, and R.Greger.(1997)
The cystic fibrosis transmembrane conductance regulator attenuates the endogenous
Ca2+ activated Cl- conductance in Xenopus ooyctes. Pflügers Arch 434:178-181
38.
Kunzelmann,K., G.Kiser, R.Schreiber, and J.R.Riordan.(1997) Inhibition of epithelial
sodium currents by intracellular domains of the cystic fibrosis transmembrane
conductance regulator. FEBS Letters 400:341-344
3
(IF 3.263)
39.
Loussouarn,G., F.Charpentier, R.Mohammad-Panah, K.Kunzelmann, I.Baro, and
D.Escande.(1997) KvLQT1 potassium channel but not IsK is the molecular target for
trans-6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethyl-chromane.
Mol.Pharmacol. 52:1131-1136
40.
Schreiber,R., R.Greger, and K.Kunzelmann.(1997) Cystic fibrosis transmembrane
conductance regulator activates water conductance in Xenopus oocytes. Pflügers Arch
434:841-847
----------------------------------------------------------------------------------------------------------------------------41. Briel,M., R.Greger, and K.Kunzelmann.(1998) Cl- transport by CFTR contributes to the
inhibition of epithelial Na+ channels in Xenopus ooyctes coexpressing CFTR and ENaC.
J.Physiol.(Lond) 508.3:825-836
42.
Goncz,K.K., K.Kunzelmann, Z.Xu, and D.C.Gruenert.(1998) Targeted replacement of
normal and mutant CFTR sequences in human airway epithelial cells using DNA
fragments. Hum.Mol.Genet. 7:1913-1919
43.
Kunzelmann,K., M.Briel, R.Schreiber, S.Ricken, R.Nitschke, and R.Greger.(1998) No
evidence for direct activation of CFTR by 8-cyclopentyl-1,3-dipropylxanthine (CPX). Cell
Physiol Biochem 8:185-193
44.
Mall,M., M.Bleich, R.Greger, M.Schürlein, J.Kühr, H.H.Seydewitz, M.Brandis, and
K.Kunzelmann.(1998) Cholinergic ion secretion in human colon requires co-activation by
cAMP. Am J Physiol 275:G1274-G1281
45.
Mall,M., M.Bleich, R.Greger, R.Schreiber, and K.Kunzelmann.(1998) The amiloride
inhibitable Na+ conductance is reduced by CFTR in normal but not in CF airways. J Clin
Invest 102:15-21
46.
Missiaen,L., I.Sienaert, S.Hyge, J.B.Parys, M.Malfait, K.Kunzelmann, and H.De
Smedt.(1998) ATP-induced Ca2+ signals in bronchial epithelial cells. Pflügers Arch
436:40-48
47.
Missiaen,L., J.B.Parys, H.DeSmedt, I.Sienaert, H.Sipma, S.Vanlingen, K.Maes,
K.Kunzelmann, and R.Casteels.(1998) Inhibition of inositol trisphosphate-induced
calcium release by cyclic ADP-ribose in A7r5 smooth-muscle and in 16HBE14obronchial mucosal cells. Biochem.J. 329:489-495
48.
Missiaen,L., H.DeSmedt, J.B.Parys, H.Sipma, I.Sienaert, S.Vanlingen, G.Bultynck,
K.Maes, K.Kunzelmann, K.Tanzawa, and R.Casteels.(1998) Functional properties of the
type-3 InsP3 receptor in 16HBE14o- bronchial mucosal cells. J.Biol.Chem. 273:89838986
49.
Schreiber,R., R.Nitschke, R.Greger, and K.Kunzelmann.(1998) CFTR activates AQP3 in
airway epithelial cells. J.Biol.Chem. 274:11811-11816
----------------------------------------------------------------------------------------------------------------------------50. Beck,S., J.Kühr, V.v.Schütz, T.Röstermund, H.H.Seydewitz, M.Brandis, R.Greger, and
K.Kunzelmann.(1999) No correlation of CF-phenotype, CFTR-Cl- currents and
expression of CFTR-mRNA. Ped.Pulmonology 27:251-259
4
51.
Bleich,M., R.Warth, M.Schmidt-Hieber, A.Schulz-Baldes, P.Hasselblatt, D.Fisch,
S.Berger, K.Kunzelmann, W.Kriz, G.Schütz, and R.Greger.(1999) Rescue of the
mineralocorticoid receptor knock-out mouse. Pflügers Arch. 438:245-254
52.
Hopf,A., R.Schreiber, R.Greger, and K.Kunzelmann.(1999) CFTR inhibits the activity of
epithelial Na+ channels carrying Liddle's syndrome mutations. J.Biol.Chem. 274:1389413899
53.
Hübner,M., R.Schreiber, A.Boucherot, A.Sanchez-Perez, P.Poronnik, D.I.Cook, and
K.Kunzelmann.(1999) Feedback inhibition of epithelial Na+ channels in Xenopus oocytes
does not require G0- or Gi2 -proteins. FEBS Letters 459:443-447
54.
Mall,M., M.Bleich, J.Kühr, M.Brandis, R.Greger, and K.Kunzelmann.(1999) CFTR mediated inhibition of amiloride sensitive sodium conductance by CFTR in human colon
is defective in cystic fibrosis. Am J Physiol 277:G709-G716
55.
Schreiber,R., A.Hopf, M.Mall, R.Greger, and K.Kunzelmann.(1999) The first nucleotide
binding fold of the cystic fibrosis transmembrane conductance regulator is important for
inhibition of the epithelial Na+ channel. Proc.Natl.Acad.Sci.USA 96:5310-5315
56.
Warth,R., K.Hamm, M.Bleich, K.Kunzelmann, T.vonHahn, R.Schreiber, E.Ullrich,
M.Mengel, N.Trautmann, P.Kindle, A.Schwab, and R.Greger.(1999) Molecular and
functional characterization of the small Ca2+-regulated K+ channel (rSK4) of colonic
crypts. Pflügers Arch 438:437-444
----------------------------------------------------------------------------------------------------------------------------57. Benzing,T., M.B.Yaffe, T.Arnould, L.Sellin, B.Schermer, B.Schilling, R.Schreiber,
K.Kunzelmann, G.G.Leparc, E.Kim, and G.Walz.(2000) 14-3-3 interacts with regulator of
G protein signaling proteins and modulates their activity. J Biol Chem 275:28167-28172
58.
Colosimo,A., K.K.Goncz, A.R.Holmes, K.Kunzelmann, G.Novelli, R.W.Malone,
M.J.Bennet, and D.C.Gruenert.(2000) Transfere and expression of foreign genes in
epithelial cells. BioTechniques 29:314-322
59.
Gloy,J., S.Reitinger, K.-G.Fischer, R.Schreiber, A.Boucherot, K.Kunzelmann, P.Mundel,
and H.Pavenstädt.(2000) Amino acid transport in mouse podocytes. Am.J.Physiol.
278:F999-F1005
60.
Kunzelmann,K., M.Hübner, M.Vollmer, R.Ruf, F.Hildebrandt, R.Greger, and
R.Schreiber.(2000) A Bartter's syndrome mutation of ROMK1 exerts dominant negative
effects on K+ conductance. Cell Physiol Biochem 10:117-124
61.
Kunzelmann,K., A.H.Beesley, N.J.King, G.Karupiah, J.A.Young, and D.I.Cook.(2000)
Influenza virus inhibits amiloride- sensitive Na+ channels in respiratory epithelia.
Proc.Natl.Acad Sci.U.S.A. 97:10282-10287
62.
Kunzelmann,K., R.Schreiber, R.Nitschke, and M.Mall.(2000) Control of epithelial Na+
conductance by the Cystic Fibrosis Transmembrane Conductance Regulator. Pflügers
Arch 440:193-201
5
63.
Mall,M., A.Wissner, M.Hübner, J.Kühr, M.Brandis, R.Greger, and K.Kunzelmann.(2000)
Effect of genistein on native epithelial tissues from normal individuals and CF patients
and on CFTR expressed in Xenopus oocytes. Br.J Pharmacol 130:1884-1892
64.
Mall,M., A.Wissner, J.Kühr, T.Gonska, M.Brandis, and K.Kunzelmann.(2000) Inhibition of
amiloride sensitive epithelial Na+ absorption by extracellular nucleotides in human normal
and CF airways. Am J Respir.Cell Mol.Biol. 23:755-761
65.
Mall,M., A.Wissner, R.Schreiber, J.Kühr, H.H.Seydewitz, M.Brandis, R.Greger, and
K.Kunzelmann.(2000) Role of KVLQT1 in cAMP mediated Cl- secretion in human
airways. Am J Respir.Cell Mol.Biol 23:283-289
66.
Mall,M.,
A.Wissner,
H.H.Seydewitz,
J.Kühr,
M.Brandis,
R.Greger,
and
K.Kunzelmann.(2000) Defective cholinergic Cl- secretion and detection of K+ secretion in
rectal biopsies from cystic fibrosis patients. Am.J.Physiol. 278:G617-G624
67.
Schreiber,R., H.Pavenstädt, R.Greger, and K.Kunzelmann.(2000) Aquaporin 3 cloned
from Xenopus laevis is regulated by the cystic fibrosis transmembrane conductance
regulator . FEBS Letters 475:291-295
----------------------------------------------------------------------------------------------------------------------------68. Boucherot,A., R.Schreiber, and K.Kunzelmann.(2001) Regulation and properties of
KCNQ1 (KVLQT1) and impact of the cystic fibrosis transmembrane conductance
regulator. J Membr.Biol 182:39-47
69.
Boucherot,A., R.Schreiber, and K.Kunzelmann.(2001) Role of CFTR's PDZ- binding
domain, NBF1 and Cl- conductance in inhibition of epithelial Na+ channels in Xenopus
oocytes. BBA 1515:64-71
70.
Greger,R., R.Schreiber, M.Mall, A.Wissner, A.Hopf, M.Briel, M.Bleich, R.Warth, and
K.Kunzelmann.(2001) Cystic Fibrosis and CFTR. Pflügers Arch 443:3-7
71.
Kerst,G., U.Beschorner, B.Unsöld, T.vonHahn, R.Schreiber, R.Greger, U.Gerlach, H.J.Lang, K.Kunzelmann, and M.Bleich.(2001) Properties and function of KCNQ1 K+
channels isolated from the rectal gland of Squalus Acanthias. Pflügers Arch 443:146-154
72.
König,J., R.Schreiber, T.Voelcker, M.Mall, and K.Kunzelmann.(2001) CFTR inhibits
ENaC through an increase in the intracellular Cl- concentration. EMBO Reports 2:1-5
73.
Kunzelmann,K. and A.Boucherot.(2001) Mechanism of the inhibition of epithelial Na+
channels by CFTR and purinergic stimulation. Kidney International 60:455-461
74.
Kunzelmann,K., M.Bleich, R.Warth, and R.Schreiber.(2001) Expression and function of
the rat colonic epithelial K+ channel KVLQT1. Clin.and Exp.Pharmacol.and Physiol.
28:79-83
75.
Kunzelmann,K., M.Hübner, R.Schreiber, R.Levy-Holzman, H.Garty, M.Bleich, R.Warth,
M.Slavik, T.von Hahn, and R.Greger.(2001) Cloning and function of the rat colonic
epithelial KVLQT1 (KCNQ1). J Membr.Biol. 179:155-164
76.
Lambert,G., B.Becker, R.Schreiber, A.Boucherot, M.Reth, and K.Kunzelmann.(2001)
BAP31 dependent expression of CFTR. J Biol Chem 276:20340-20345
6
77.
Schreiber,R., P.Kindle, T.Benzing, G.Walz, and K.Kunzelmann.(2001) Control of the
Cystic Fibrosis Transmembrane Conductance Regulator by alphaGi and RGS proteins.
BBRC 281:917-923
----------------------------------------------------------------------------------------------------------------------------78. Boucherot,A., R.Schreiber, H.Pavenstädt, and K.Kunzelmann.(2002) Cloning and
expression
of
the
mouse
glomerular
podoplanin
homologue
gp38P.
Nephrol.Dial.Transplant 17:978-984
79.
König,J., R.Schreiber, M.Mall, and K.Kunzelmann.(2002) No evidence for inhibition of
ENaC through CFTR mediated release of ATP. Biochim Biophys Acta 1565:17-28
80.
Kunzelmann,K., R.Schreiber, and D.I.Cook.(2002) Mechanisms for inhibition of
amiloride-sensitive Na+ absorption by extracellular nuceotides in mouse trachea. Pflügers
Arch 444:220-226
81.
Kunzelmann,K., R.Schreiber, J.König, and M.Mall.(2002) Activation of ion secretion via
proteinase activated receptors (PAR2) in colon and airways. Cell Biochem Biophys 26:16
82.
Mall,M., T.Gonska, J.Thomas, S.Hirtz, R.Schreiber, and K.Kunzelmann.(2002) Activation
of ion secretion via proteinase activated receptors (PAR2) in the human colon.
Am.J.Physiol 282:200-210
83.
Oceandy,D., B.J.McMorran, S.N.Smith, R.Schreiber, K.Kunzelmann, E.W.F.Alten,
D.A.Hume, and B.J.Wainwright.(2002) Gene complementation of airway epithelium in the
cystic fibrosis mouse in necessary and sufficient to correct the pathogen clearance and
inflammatory abnormalities. Hum.Mol.Genet. 11:1059-1067
----------------------------------------------------------------------------------------------------------------------------84. Kunzelmann,K.(2003) ENaC is inhibited by an increase in the intracellular Clconcentration mediated through activation of Cl- channels. Pflügers Arch 445:505-512
85.
Kunzelmann,K. and M.Mall.(2003) Pharmacotherapy of the Ion Transport Defect in
Cystic Fibrosis: Potential Role of P2Y2 Receptor Agonists. American Journal of
Respiratory Medicine 3:299-329
86.
Mall,M., T.Gonska, J.Thomas, R.Schreiber, H.H.Seydewitz, J.Kuehr, M.Brandis, and
K.Kunzelmann.(2003) Role of basolateral K+ channels in Ca2+ activated Cl- secretion in
human normal and cystic fibrosis airway epithelia. Pediatric Research 53:608-618
87.
Oceandy,D., B.J.McMorran, R.Schreiber, B.Wainwright, and K.Kunzelmann.(2003) GFPtagged CFTR transgene is functional in the G551D Cystic Fibrosis mouse colon. J
Membr.Biol 192:159-167
88.
Schreiber,M., B.Mürle, J.Sun, and K.Kunzelmann.(2003) Electrolyte transport in the
mouse trachea: role of luminal K+ conductance. J Membr.Biol 189:143-151
Schreiber,R., J.König, and K.Kunzelmann.(2003) Impact of Cl- but not osmotic swelling
on inhibition of Na+ absorption by purinergic stimulation and activation of CFTR. J
Membr.Biol 192:101-110
-----------------------------------------------------------------------------------------------------------------------------
89.
7
90.
Adam,G., J.Ousingsawat, R.Schreiber, and K.Kunzelmann.(2004) Increase in
intracellular Cl- concentration by cAMP and Ca2+ dependent stimulation of M1 collecting
duct cells. Pflügers Arch 449:470-478
91. Gruenert, D.C., K.Kunzelmann, G.Novelli, A.Colosimo, R.Kapsa, and
Letter to the editors. Oligonucleotides 14:157-158
E. Bruscia. (2004)
92.
Hirtz,S., T.Gonska, H.H.Seydewitz, J.Thomas, P.Greiner, J.Kuehr, M.Brandis, I.eichler,
H.Rocha, A.-I.Lopes, C.Barreto, A.Ramalho, M.Amaral, K.Kunzelmann, and
M.Mall.(2004) CFTR Cl- channel function in native human colon correlates with the
genotype and the phenotype in cystic fibrosis. Gastroenterology 127:1085-1095
93.
Kunzelmann,K., T.Bachhuber, R.R.Regeer, D.Markovich, J.Sun, and R.Schreiber.(2004)
Purinergic inhibition of the epithelial Na+ channel ENaC via hydrolysis of PIP2 . FASEB J
18:142-163
94.
Kunzelmann,K., J.König, D.Markovich, N.King, G.Karupiah, and D.I.Cook.(2004) Acute
effects of parainfluenza virus on epithelial electrolyte transport. J Biol Chem 279:4876048766
95.
Kunzelmann,K., D.Sun, and J.König.(2004) Effect of dietary lectins on ion transport in
epithelia. Br.J.Pharmacol 142:1-8
96. Mall,M., S.M.Kreda, A.Mengos, T.J.Jensen, S.Hirtz, H.H.Seydewitz, J.Yankaskas,
K.Kunzelmann, J.R.Riordan, and R.C.Boucher.(2004) The DeltaF508 mutation results in
loss of CFTR function and mature protein in native human colon. Gastroenterology
126:32-41
97. Mall,M., S.Hirtz, T.Gonska, and K.Kunzelmann.(2004) Assessment of CFTR function in
rectal biopsies for the diagnosis of cystic fibrosis. Journal of Cystic Fibrosis 3:165-169
98. Schreiber,R., G.D.Bartoszyk, and K.Kunzelmann.(2004) The k-opioid receptor agonist
asimadoline inhibits epithelial transport in mouse trachea and colon. Eur.J Pharmacol
503:185-190
99. Schreiber,R., A.Boucherot, B.Mürle, J.Sun, and K.Kunzelmann.(2004) Control of
epithelial ion transport by Cl- and PDZ proteins. J Membr.Biol 199:85-98
----------------------------------------------------------------------------------------------------------------------------100. Bachhuber,T., J.König, T.Voelcker, B.Mürle, R.Schreiber, and K.Kunzelmann.(2005)
Chloride interference with the epithelial Na+ channel ENaC. J Biol Chem 280:3158731594
101. da Paula,A.C., A.Ramalho, C.Farinha, J.Cheng, R.Maurisse, D. C. Gruenert, J.
Ousingsawat, K. Kunzelmann, and M.D.Amaral. (2005) Characterization of a novel
airway submucosal gland cellular model for cystic fibrosis studies. Cell Physiol Biochem
15:251-262
102. Dawson,P.A., K.J.Pirlo, S.E.Steane, K.A.Nguyen, K.Kunzelmann, Y.J.Chien, and
D.Markovich.(2005) The rat Na+ sulfate cotransporter rNaS2: Functional
characterisation, tissue distribution and gene (slc13a4) structure. Pflügers Arch 450:262268
8
103.
Kunzelmann,K., J.Sun, D.Markovich, J.König, B.Mürle, M.Mall, and R.Schreiber.(2005)
Control of ion transport in mammalian airways by protease activated receptors type 2
(PAR-2). FASEB J 19:969-970
104.
Markovich,D., R.R.Regeer, K.Kunzelmann, and P.A.Dawson.(2005) Functional
characterization and genomic organization of the human Na(+)-sulfate cotransporter
hNaS2 gene (SLC13A4). Biochem Biophys.Res.Commun. 326:729-734
105.
Mendes,F., J.Wakefield, T.Bachhuber, M.Barroso, Z.Bebok, D.Penque, K.Kunzelmann,
and M.Amaral.(2005) Establishment and Characterization of a novel polarized MDCK
epithelial cellular model for CFTR studies. Cell Physiol Biochem 16:281-290
106.
Schreiber,R. and K.Kunzelmann.(2005) Purinergic P2Y6 receptors induce Ca2+ and
CFTR dependent Cl- secretion in mouse trachea. Cell Physiol Biochem 16:99-108
-------------------------------------------------------------------------------------------------------------------------------107. Kunzelmann,K., K.Scheidt, B.Scharf, J.Ousingsawat, R.Schreiber, B.J.Wainwright, and
B.McMorran.(2006) Pseudomonas flagellin inhibits Na+ transport in airway epithelia.
FASEB J 20:545-558
108.
Bloch M, Ousingsawat J, Simon R, Gasser TC, Mihatsch MJ, Kunzelmann K, and
Bubendorf L (2006) KCNMA1 gene amplification promotes tumor cell proliferation in
prostate cancer. Oncogene 459: 443-447.
109.
Huber,T.B., B.Schermer, R.U.Muller, M.Hohne, M.Bartram, A.Calixto, H.Hagmann,
C.Reinhardt, F.Koos, K.Kunzelmann, E.Shirokova, D.Krautwurst, C.Harteneck,
M.Simons, H.Pavenstadt, D.Kerjaschki, C.Thiele, G.Walz, M.Chalfie, and
T.Benzing.(2006) Podocin and MEC-2 bind cholesterol to regulate the activity of
associated ion channels. Proc.Natl.Acad.Sci.U.S.A. 103:17079-17086
110.
Sousa,M., J.Ousingsawat, R.Seitz, S.Puntheeranurak, A.Regalado, A.Schmidt, T.Grego,
C.Jansakul, M.D.Amaral, R.Schreiber, and K.Kunzelmann.(2006) Thai medical plant
extract from Phyllanthus acidus as a potential treatment for cystic fibrosis.
Mol.Pharmacol. 71:366-376
111.
Spitzner,M., J.Ousingsawat, K.Scheidt, K.Kunzelmann, and R.Schreiber.(2006) Role of
voltage gated K+ channels for proliferation of colonic cancer cells. FASEB J 21:35-44
112.
Stumpf,A., J.R.Martins, K.Kunzelmann, K.Wenners-Epping, S.Huber, J.Häberle, S.Falk,
A.Dübbers, M.Walte, H.Oberleithner, and H.Schillers.(2006) IADS, a decomposition
product of DIDS, activates a cation conductance in human erythrocytes and Xenopus
laevis oocytes. Cell Physiol Biochem 18:243-252
-------------------------------------------------------------------------------------------------------------------------------113. Kunzelmann K, Meanger J, King NJ, and Cook DI (2007) Inhibition of airway Na+
transport by respiratory syncytial virus. J Virology 81: 3714-3720.
114.
Ousingsawat J, Spitzner M, Puntheeranurak S, Terracciano L, Tornillo L, Bubendorf L,
Kunzelmann K, and Schreiber R (2007) Expression of voltage gated potassium channels
in human and mouse colonic carcinoma. Clinical Cancer Research 13: 824-831.
115.
Puntheeranurak S, Schreiber R, Spitzner M, Ousingsawat J, Krishnamra N, Kunzelmann
K. (2007) Control of ion transport in mouse proximal and distal colon by prolactin.. Cell
Physiol Biochem 19:77-88
9
-------------------------------------------------------------------------------------------------------------------------------116.
Bachhuber T, Almaca J, AlDehni F, Mehta A, Amaral M, Schreiber R, and Kunzelmann K
(2008) Regulation of the epithelial Na+ channel by protein kinase CK2. J Biol Chem 283:
13225-13232.
117.
Barro Soria R, Schreiber R, and Kunzelmann K (2008) Bestrophin 1 and 2 are
components of the Ca2+ activated Cl- conductance in mouse airways. BBA 1783: 19932000.
118.
Grangeia A, Barro Soria R, Carvalho F, Damas AM, Mauricio AC, Kunzelmann K, Barros
A, and Sousa M (2008) Molecular and Functional Characterization of CBAVD-Causing
Mutations Located in CFTR Nucleotide-Binding Domains. Cell Physiol Biochem 22: 7992.
119.
Hennig B, Schultheiss G, Kunzelmann K, and Diener M (2008) Ca( 2+ )-Induced Cl (-)
Efflux at Rat Distal Colonic Epithelium. J Membr.Biol. 221: 61-72.
120.
Illek B, Maurisse R, Wahler L, Kunzelmann K, Fischer H, and Gruenert DC (2008) Cl
Transport in Complemented CF Bronchial Epithelial Cells Correlates with CFTR mRNA
Expression Levels. Cell Biochem Biophys 22: 57-68.
121.
Milenkovic VM, Langmann T, Schreiber R, Kunzelmann K, and Weber BHF (2008)
Molecular evolution and functional divergence of the bestrophin protein family. BMC
Evolutionary Biology 8: 72-78.
122.
Ousingsawat J, Spitzner M, Schreiber R, and Kunzelmann K (2008) Upregulation of
colonic ion channels in APCMin/+ mice. Pflügers Arch 456: 847-855.
123.
Schreiber R, Castrop H, and Kunzelmann K (2008) Allergen induced airway
hyperresponsiveness is absent in ecto-5´-nucleotidase (CD73) deficient mice. Pflugers
Arch 457: 431-440.
124.
Spitzner M, Martins JR, Barro Soria R, Ousingsawat J, Scheidt K, Schreiber R, and
Kunzelmann K (2008) Eag1 and Bestrophin 1 are upregulated in fast growing colonic
cancer cells. J Biol Chem 283: 7421-7428.
-------------------------------------------------------------------------------------------------------------------------------125. AlDehni F, Spitzner M, Martins JR, Barro Soria R, Schreiber R, and Kunzelmann K
(2009) Role of bestrophin for proliferation and in epithelial to mesenchymal transition. J
Am Soc Nephrol 20: 1556-1564.
126
Almaca J, Ousingsawat J, Hieke B, Viollet B, Schreiber R, Amaral MD, and Kunzelmann
K (2009) AMPK controls epithelial Na+ channels through Nedd4-2 and causes an
epithelial phenotype when mutated. Pflugers Arch 458: 713-721.
127
Almaca J, Tian Y, AlDehni F, Ousingsawat J, Kongsuphol P, Rock JR, Harfe BD,
Schreiber R, and Kunzelmann K (2009) TMEM16 proteins produce volume regulated
chloride currents that are reduced in mice lacking TMEM16A. J Biol Chem 284: 2857128578.
128
Barro Soria R, Spitzner M, Schreiber R, and Kunzelmann K (2009) Bestrophin 1 enables
Ca2+ activated Cl- conductance in epithelia. J Biol Chem 284: 29405-29412.
10
129.
Barro Soria R, AlDehni F, Almaca J, Witzgall R, Schreiber R, and Kunzelmann K (2009)
ER localized bestrophin1 acts as a counter-ion channel to activate Ca2+ dependent ion
channels TMEM16A and SK4. Pflügers Arch 459: 485-497
130.
Faria D, Schreiber R, and Kunzelmann K (2009) CFTR is activated through stimulation of
purinergic P2Y2 receptors. Pflügers Arch 457: 1373-1380.
131.
Kongsuphol P, Hieke B, Ousingsawat J, Almaca J, Viollet B, Schreiber R, and
Kunzelmann K (2009) Regulation of Cl- secretion by AMPK in vivo. Pflügers Arch (in
press).
132.
Kongsuphol P, Cassidy D, Hieke B, Treharne KJ, Schreiber R, Mehta A, and
Kunzelmann K (2009) Mechanistic insight into control of CFTR by AMPK. J Biol Chem
284: 5645-5653.
133.
Milenkovic VM, Schreiber R, Barro Soria R, AlDehni F, and Kunzelmann K (2009)
Functional assembly and purinergic activation of bestrophins. Pflugers Arch 458: 431441.
134.
Ousingsawat J, Martins JR, Schreiber R, Rock JR, Harfe BD, and Kunzelmann K (2009)
Loss of TMEM16A causes a defect in epithelial Ca2+ dependent chloride transport. J Biol
Chem 284: 28698-28703
135.
Rotte A, Bhandaru M, Föller M, Biswas R, Mack A, Friedrich B, Rexhapaj R, Nasri O,
Ackermann TF, Boini KM, Kunzelmann K, Behrens J, and Lang F (2009) APC sensitive
gastric acid secretion. Cell Physiol Biochem 23: 133-142.
136.
Treharne KJ, Xu Z, Chen J-H, Best OG, Cassidy D, Gruenert DC, Hegyi P, Gray L,
Sheppard D, Kunzelmann K, and Mehta A (2009) Inhibition of protein kinase CK2 closes
the CFTR Cl- channel, but has no effect on the cystic fibrosis mutant F508-CFTR. Cell
Physiol Biochem 24:347-360
-------------------------------------------------------------------------------------------------------------------------------137. Koehl GE, Spitzner M, Ousingsawat J, Schreiber R, Geissler EK, and Kunzelmann K
(2010) Rapamycin Inhibits Oncogenic Intestinal Ion Channels and Neoplasia in
APCMin/+ Mice. Oncogene 29:1553-1560
138.
Preston P, Wartosch L, Gunzel D, Fromm M, Kongsuphol P, Ousingsawat J,
Kunzelmann K, Barhanin J, Warth R, and Jentsch TJ (2010) Disruption of the K+ channel
beta-subunit KCNE3 reveals an important role in intestinal and tracheal Cl- transport.
J.Biol.Chem 285:7165-7175
139.
Schreiber R, Uliyakina I, Kongsuphol P, Warth R, Mirza M, Martins JR, and Kunzelmann
K (2010) Expression and Function of Epithelial Anoctamins. J.Biol.Chem 285:7838-7845
140.
Kongsuphol P, Cassidy D, Romeiras F, Schreiber R, Mehta A, and Kunzelmann K (2010)
Metformin treatment of diabetes mellitus increases the risk for pancreatitis in patients
bearing the CFTR-mutation S573C. Cell Physiol Biochem 24:347-360
141.
Carota I, Theilig F, Oppermann M, Kongsuphol P, Rosenauer A, Schreiber R, Jensen BL,
Walter S, Kunzelmann K, and Castrop H (2010) Localization and Functional
Characterization of the Human NKCC2 Isoforms. Acta Physiol (Oxf) 199:327-338
11
142.
Skals M, Jensen UB, Ousingsawat J, Kunzelmann K, Leipziger J, and Praetorius HA
(2010) E. coli alpha-hemolysin triggers shrinkage of erythrocytes via KCa3.1 and
TMEM16A channels with subsequent phosphatidyl serine exposure. J.Biol.Chem
285:15557-15565
143.
Duning K, Rosenbusch D, Schlueter MA, Tian Y, Kunzelmann K, Meyer N, Schulze U,
Markoff A, Pavenstaedt H, and Weide T (2010) Polycystin-2 activity is controlled by
transcriptional coactivator with PDZ binding motif and pals1-associated tight junction
protein. J Biol.Chem 285:33584-33588
144.
Faria D, Dahimene S, Alessio L, Scott-Ward TS, Schreiber R, Kunzelmann K, and
Amaral MD (2010) Effect of Annexin A5 on CFTR: regulated traffic or scaffolding?
Molecular Membrane Biology 28:14-29
-------------------------------------------------------------------------------------------------------------------------------145. Martins JR, Kongsuphol P, Sammels E, Daimène S, AlDehni F, Clarke L, Schreiber R,
DeSmedt H, Amaral MD, and Kunzelmann K (2011) F508del-CFTR increases
intracellular Ca2+ signaling that causes enhanced calcium-dependent Cl- conductance in
cystic fibrosis. Biochim Biophys Acta 1812: 1385-1392.
146.
Tian Y, Kongsuphol P, Hug MJ, Ousingsawat J, Witzgall R, Schreiber R, and
Kunzelmann K (2011) Calmodulin-dependent activation of the epithelial calciumdependent chloride channel TMEM16A. FASEB J 25: 1058-1068.
147.
Ousingsawat J, Tian Y, AlDehni F, Roussa E, Schreiber R, Mirza M, Cook DI, and
Kunzelmann K (2011) Rotavirus toxin NSP4 activates the calcium dependent chloride
channel TMEM16A and inhibits absorptive Na+transport. Pflügers Arch 461: 579-589.
148.
Ousingsawat J, Schreiber R, and Kunzelmann K (2011) Differential contribution of
SLC26A9 to Cl(-) conductance in polarized and non-polarized epithelial cells. J Cell
Physiol. 227: 2323-2329.
149.
Ousingsawat J, Kongsuphol P, Schreiber R, and Kunzelmann K (2011) CFTR and
TMEM16A are Separate but Functionally Related Cl Channels. Cell Physiol Biochem. 28:
715-724.
150.
Martins JR, Faria D, Kongsuphol P, Reisch B, Schreiber R, and Kunzelmann K (2011)
Anoctamin 6 is an essential component of the outwardly rectifying chloride channel.
Proc.Natl.Acad.Sci.U.S.A. 108: 18168-18172.
151.
Luz S, Kongsuphol P, Mendes AI, Romeiras F, Sousa M, Schreiber R, Matos P, Jordan
P, Mehta A, Amaral MD, Kunzelmann K, and Farinha CM (2011) The contribution of CK2
and spleen tyrosine kinase (SYK) to CFTR trafficking and PKA-induced activity. Mol.Cell
Biol. 31:4392-4404
152.
Kongsuphol P, Schreiber R, Kraidith K, and Kunzelmann K (2011) CFTR induces
extracellular acid sensing in Xenopus oocytes which activates endogenous Ca(2+)activated Cl (-) conductance. Pflugers Arch. 462: 479-487.
------------------------------------------------------------------------------------------------------------------------------153. Duvvuri U, Shiwarski DJ, Xiao D, Bertrand C, Huang X, Edinger RS, Rock J, Harfe BD,
Henson BJ, Kunzelmann K, Schreiber R, Seethala RR, Egloff AM, Chen X, Lui VW,
Grandis JR, and Gollin SM (2012) TMEM16A, induces MAPK and contributes directly to
tumorigenesis and cancer progression. Cancer Res. 72: 3270-3281.
12
154.
Faria D, Lentze N, Almaca J, Luz S, Alessio L, Tian Y, Martins JP, Cruz P, Schreiber R,
Rezwan M, Farinha CM, Auerbach D, Amaral MD, and Kunzelmann K (2012) Regulation
of ENaC biogenesis by the stress response protein SERP1. Pflugers Arch. 463: 819-827.
155.
Oeggerli M, Tian Y, Ruiz C, Wijker B, Sauter G, Obermann E, Guth U, Zlobec I, Sausbier
M, Kunzelmann K, and Bubendorf L (2012) Role of KCNMA1 in Breast Cancer.
PLoS.ONE. 7: e41664.
156.
Ruiz C, Martins JR, Rudin F, Schneider S, Dietsche T, Fischer CA, Tornillo L,
Terracciano LM, Schreiber R, Bubendorf L, and Kunzelmann K (2012) Enhanced
Expression of ANO1 in Head and Neck Squamous Cell Carcinoma Causes Cell Migration
and Correlates with Poor Prognosis. PLoS.ONE. 7: e43265.
157.
Sousa M, Servidoni MF, Vinagre AM, Ramalho AS, Bonadia LC, Felicio V, Ribeiro MA,
Uliyakina I, Marson FA, Kmit A, Cardoso SR, Ribeiro JD, Bertuzzo CS, Sousa L,
Kunzelmann K, Ribeiro AF, and Amaral MD (2012) Measurements of CFTR-Mediated
Cl(-) Secretion in Human Rectal Biopsies Constitute a Robust Biomarker for Cystic
Fibrosis Diagnosis and Prognosis. PLoS.ONE. 7: e47708.
158.
Szteyn K, Schmid E, Nurbaeva MK, Yang W, Munzer P, Kunzelmann K, Lang F, and
Shumilina E (2012) Expression and Functional Significance of the Ca-Activated Cl(-)
Channel ANO6 in Dendritic Cells. Cell Physiol Biochem. 30: 1319-1332.
159.
Tian Y, Schreiber R, Wanitchakool P, Kongsuphol P, Sousa M, Uliyakina I, Palma M,
Faria D, Traynor-Kaplen AE, Fragata JI, Amaral MD, and Kunzelmann K (2012) Control
of TMEM16A by INO-4995 and other inositolphosphates. Br.J Pharmacol 168: 253-265.
160.
Tian Y, Schreiber R, and Kunzelmann K (2012) Anoctamins are a family of Ca2+
activated Cl- channels. J Cell Sci 125: 4991-4998.
161.
Tosoni K, Stobbart M, Cassidy DM, Venerando A, Pagano MA, Luz S, Amaral MD,
Kunzelmann K, Pinna LA, Farinha CM, and Mehta A (2012) CFTR mutations altering
CFTR fragmentation. Biochem.J. 449: 295-305.
-------------------------------------------------------------------------------------------------------------------------------162. Almaca J, Faria D, Sousa M, Uliyakina I, Conrad C, Sirianant L, Clarke LA, Martins JP,
Santos M, Heriche JK, Huber W, Schreiber R, Pepperkok R, Kunzelmann K, and Amaral
MD (2013) High-Content siRNA Screen Reveals Global ENaC Regulators and Potential
Cystic Fibrosis Therapy Targets. Cell. 154: 1390-1400.
163.
Kmit A, van Kruchten R, Ousingsawat J, Mattheij NJ, Senden-Gijsbers B, Heemskerk
JW, Bevers EM, and Kunzelmann K (2013) Calcium-activated and apoptotic phospholipid
scrambling induced by Ano6 can occur independently of Ano6 ion currents. Cell death
and disease 25: 4:e611.
164.
Rahmati N, Kunzelmann K, Xu J, Barone S, Sirianant L, De Zeeuw CI, and Soleimani M
(2013) Slc26a11 is prominently expressed in the brain and functions as a chloride
channel: expression in Purkinje cells and stimulation of V H-ATPase. Pflugers Arch. 465:
1583-1597.
165.
Servidoni MF, Sousa M, Vinagre AM, Cardoso SR, Ribeiro MA, Meirelles LR, de
Carvalho RB, Kunzelmann K, Ribeiro AF, Ribeiro JD, and Amaral MD (2013) Rectal
13
forceps biopsy procedure in cystic fibrosis: technical aspects and patients perspective for
clinical trials feasibility. BMC.Gastroenterol. 13: 91.
-------------------------------------------------------------------------------------------------------------------------------166. Buchholz B, Schley G, Faria D, Kroening S, Willam C, Schreiber R, Klanke B, Burzlaff N,
Kunzelmann K, and Eckardt KU (2014) HIF-1α causes renal cyst expansion through
calcium-activated chloride secretion. J Am Soc Nephrol 25: 465-474.
167.
Buchholz B, Faria D, Schley G, Schreiber R, Eckardt KU, Kunzelmann K (2014)
Anoctamin 1 induces calcium-activated chloride secretion and proliferation of renal cyst
forming epithelial cells. Kidney Int 85: 1058-1067.
168.
Faria D, Schlatter E, Witzgall R, Grahammer F, Bandulik S, Schweda F, Bierer S, Rock
JR, Heitzmann D, Kunzelmann K, and Schreiber R (2014) The calcium activated chloride
channel Anoctamin 1 contributes to the regulation of renal function. Kindey Int. 85: 13691381.
169.
Schreiber R, Faria D, Skryabin BV, Rock JR, and Kunzelmann K (2014) Anoctamins
support calcium-dependent chloride secretion by facilitating calcium signaling in adult
mouse intestine. Pflügers Arch (in press) .
170.
Schurek EM, Voelker LA, Tax J, Lamkemeyer T, Rinschen MM, Ungrue D, Kratz JE, III,
Sirianant L, Kunzelmann K, Chalfie M, Schermer B, Benzing T, and Hoehne M (2014) A
disease-causing mutation illuminates protein membrane topology of the kidneyexpressed PHB domain protein podocin. J Biol.Chem. 289: 11262-11271
171.
Sirianant L, Ousingsawat J, Tian Y, Schreiber R, and Kunzelmann K (2014) TMC8
(EVER2) attenuates intracellular signaling by Zn2+ and Ca2+ and suppresses activation
of Cl- currents. Cell Signal.(in press)
-------------------------------------------------------------------------------------------------------------------------------172. Botelho HM, Uliyakina I, Awatade NT, Proenca MC, Tischer C, Sirianant L, Kunzelmann
K, Pepperkok R, and Amaral MD (2015) Protein traffic disorders: an effective highthroughput fluorescence microscopy pipeline for drug discovery. Sci Rep. 5: 9038.
173.
Hammer C, Wanitchakool P, Sirianant L, Papiol S, Monnheimer M, Faria D, Ousingsawat
J, Schramek N, Schmitt C, Margos G, Michel A, Kraiczy P, Pawlita M, Schreiber R,
Schulz TF, Fingerle V, Tumani H, Ehrenreich H, and Kunzelmann K (2015) A coding
variant of ANO10, affecting volume regulation of macrophages, is associated with
Borrelia seropositivity. Mol.Med. (in press)
174.
Milenkovic A, Brandl C, Milenkovic VM, Jendrike T, Sirianant L, Wanitchakool P,
Zimmermann S, Reif CM, Horling F, Schrewe H, Strünker T, Alvarez L, Schreiber R,
Kunzelmann K, Wetzel CH, and Weber BHF (2015) Bestrophin1 is the volume-regulated
anion channel in mouse sperm and human retinal pigment epithelium. Proc.Natl.Acad.Sci
U.S A.(in press)
175.
Ousingsawat J, Wanitchakool P, Schreiber R, Wuelling M, Vortkamp A, and Kunzelmann
K (2015) Anoctamin 6 controls bone mineralization by activating the calcium transporter
NCX1. J Biol Chem.(in press) .
B) Reviews
14
1.
Greger,R., K.Kunzelmann, and L.Gerlach. (1990) Mechanisms of chloride transport in
secretory epithelia. Ann New York Acad Sc 574: 403-415.
----------------------------------------------------------------------------------------------------------------------------2. Greger,R. and K.Kunzelmann.(1993) The regulation of Cl- channels in epithelia. Verh
Dtsch Zool Ges 86:111-117
3.
Kunzelmann,K., M.Tilmann, H.C.Estler, and R.Greger.(1993) Tonische Hemmung
Epithelialer Chloridkanäle. Pädiatrie aktuell 4:9-12
----------------------------------------------------------------------------------------------------------------------------4. Greger,R. and K.Kunzelmann.(1994) Physiologie und Pathophysiologie des
Ionentransportes im Respirationsepithel. Atemwegs-und Lungenkrankheiten 7:361-362
----------------------------------------------------------------------------------------------------------------------------5. Kunzelmann,K., D.C.Lei, K.Eng, L.C.Escobar, T.Koslowsky, J.H.Widdicombe, and
D.C.Gruenert.(1995) Epithelial cell specific properties and genetic complementation in
deltaF508 cystic fibrosis nasal polyp cell line. In vitro 31:617-624
----------------------------------------------------------------------------------------------------------------------------6. Kunzelmann,K. and R.Greger.(1996) Mukoviszidose: Vom Krankheitssymptom zum
Ionenkanal. In: Mitteilungsorgan der Gesellschaft für Zellbiologie 3:20-21
----------------------------------------------------------------------------------------------------------------------------7. Greger,R., M.Bleich, J.Leipziger, D.Ecke, M.Mall, and K.Kunzelmann.(1997) Regulation
of ion transport in colonic crypts. News Physiol Sciences 12:62-66
8. Kunzelmann,K.(1997) Regulation and amiloride binding site of epithelial Na+ channels.
Kidney and Blood Press Res 20:151-153
----------------------------------------------------------------------------------------------------------------------------9. Kunzelmann,K. (1999) The Cystic Fibrosis Transmembrane Conductance Regulator and
its function in epithelial transport. Rev.Physiol.Biochem.Pharmacol. 137: 1-70.
10.
Kunzelmann,K. and R.Schreiber. (1999) CFTR, a regulator of channels. J.Membr.Biol
168: 1-8.
----------------------------------------------------------------------------------------------------------------------------11. Kunzelmann,K., A.Beesley, N.King, G.Karupiah, J.Young, and D.I.Cook.(2000)
Unexpected effects of pathogens on epithelial Na+ channels. J Korean.Med Sci. 15 :5760
12.
Kunzelmann,K. and R.Nitschke. (2000) Defects in processing and trafficking of CFTR.
Experimental Nephrology 8: 332-342.
----------------------------------------------------------------------------------------------------------------------------13. Kunzelmann,K. and M.Mall. (2001) Pharmacotherapy of the ion transport defect in cystic
fibrosis. Clin Exp Pharmacol Physiol 28: 857-867.
14.
Kunzelmann,K., J.König, and R.Schreiber.(2001) Interaction of the epithelial Na+ channel
ENaC and CFTR: Crosstalk via Cl-? Kidney and Blood Press Res 24:399-402
15.
Kunzelmann,K. (2001) CFTR: Interacting with everything? News Physiol Sciences 17:
167-170.
----------------------------------------------------------------------------------------------------------------------------16. Kunzelmann,K. and M.Mall. (2002) Electrolyte transport in the colon: Mechanisms and
implications for disease. Physiological Reviews 82: 245-289.
-----------------------------------------------------------------------------------------------------------------------------
15
17.
Kunzelmann,K. (2004) First encounter: How pathogens compromise epithelial transport.
Physiology 19:240-244.
18. Kunzelmann,K., J.Sun, D.Markovich, J.König, B.Mürle, T.Voelcker, M.Mall, and
R.Schreiber. (2004) Inhibition of epithelial Na+ channels by CFTR and purinergic
agonists: Mechanisms and significance for CF. Acta Nova Leopoldina 336:177-182.
----------------------------------------------------------------------------------------------------------------------------19. Mall,M. and K.Kunzelmann.(2005) Correction of the CF defect by curcumin: Hypes and
disappointments. BioEssays 27:9-13
20. Kunzelmann,K., T.Bachhuber, G.Adam, T.Voelcker, B.Mürle, M.Mall, and
R.Schreiber.(2005) Role of CFTR and other ion channels in cystic fibrosis. In: Defects of
Secretion in Cystic Fibrosis. Carsten Schultz (Ed). Adv Exp Med Biol. 558.:23-41
21. Kunzelmann,K.(2005) Ion channels and cancer. J Membr.Biol 205:159-173
----------------------------------------------------------------------------------------------------------------------------22. Dawson,P.A., K.J.Pirlo, S.E.Steane, K.Kunzelmann, Y.J.Chien, and D.Markovich.(2006)
Molecular cloning and characterization of the mouse Na+ sulfate cotransporter gene
(Slc13a4): structure and expression. Genes Genet Syst 81:265-272
23. Kunzelmann, K., Spitzner M., Ousingsawat J., Martins J. R. and Schreiber R.(2006)
Expression von Ionenkanälen beim Kolonkarzinom: Neue diagnostische und
therapeutische Möglichkeiten? Onkologie heute 2, 18-21
----------------------------------------------------------------------------------------------------------------------------24. Kunzelmann,K., V.M.Milenkovic, M.Spitzner, R.Barro Soria, and R.Schreiber.(2007)
Calcium dependent chloride conductance in epithelia: Is there a contribution by
Bestrophin? Pflügers Arch 454: 879-889
25.
Amaral,M.D. and K.Kunzelmann.(2007) Molecular Targeting of CFTR as a Therapeutic
Approach to Cystic Fibrosis. Trends Pharmacol Sci. 28:334-341
----------------------------------------------------------------------------------------------------------------------------26. Kunzelmann K, Kongsuphol P, AlDehni F, Tian Y, Ousingsawat J, Warth R, and
Schreiber R (2009) Bestrophin and TMEM16 - Ca2+ activated Cl- channels with different
functions. Cell Calcium 46: 233-241.
----------------------------------------------------------------------------------------------------------------------------27. Kunzelmann K, Kongsuphol P, Chootip K, Toledo C, Martins JR, Almaca J, Tian Y,
Witzgall R, Ousingsawat J, and Schreiber R (2011) Role of the Ca(2+)-activated Cl(-)
channels bestrophin and anoctamin in epithelial cells. Biol Chem. 392:125-134
28.
Kunzelmann K (2011) Assessment of CFTR-function. In: Cystic Fibrosis: Methods and
Protocols. Amaral, M. and Kunzelmann, K. (Editors). Methods in Molecular Biology 742
(volume 1): 407-418.
29.
Kunzelmann K, Tian Y, Martins JR, Faria D, Kongsuphol P, Ousingsawat J, Thevenod F,
Roussa E, Rock JR, and Schreiber R (2011) Anoctamins. Pflugers Arch. 462: 195-208.
30.
Almaca J, Dahimene S, Appel N, Conrad C, Kunzelmann K, Pepperkok R, and Amaral
MD (2011) Functional Genomics Assays to Study CFTR Traffic and ENaC Function. In:
Cystic Fibrosis: Methods and Protocols. Amaral, M. and Kunzelmann, K. (Editors).
Methods in Molecular Biology 742 (volume 2): 249-264.
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16
31.
Kunzelmann K, Schreiber R, Kmit A, Jantarajit W, Martins JR, Faria D, Kongsuphol P,
Ousingsawat J, and Tian Y (2012) Expression and function of epithelial anoctamins.
Exp.Physiol. 97: 184-192.
32.
Kunzelmann K and Schreiber R (2012) Airway epithelial cells-Hyperabsorption in CF?
Int.J Biochem Cell Biol. 44:1232-1235
33.
Kunzelmann K, Tian Y, Martins JR, Faria D, Kongsuphol P, Ousingsawat J, Wolf L, and
Schreiber R (2012) Cells in focus: Airway epithelial cells-Functional links between CFTR
and anoctamin dependent Cl(-) secretion. Int.J.Biochem.Cell Biol. 44:1897-1900
----------------------------------------------------------------------------------------------------------------------------34. Kunzelmann K and Mehta A (2013) CFTR: a hub for kinases and cross-talk of cAMP and
Ca. FEBS J. 280: 4417-4429.
----------------------------------------------------------------------------------------------------------------------------35. Kunzelmann K and Schreiber R (2014) Chloride secretion, anoctamin 1 and Ca2+
signaling. Channels 8:387-388
36.
37.
Kunzelmann K, Nilius B, Owsianik G, Schreiber R, Ousingsawat J, Sirianant L,
Wanitchakool P, Bevers EM, and Heemskerk JW (2014) Molecular functions of
anoctamin 6 (TMEM16F): A chloride channel, cation channel or phospholipid
scramblase? Pflügers Arch 466: 407-414.
Wanitchakool P, Wolf L, Koehl G, Sirianant L, Gaumann A, Schreiber R, Duvvuri U, and
Kunzelmann K (2014) Role of Anoctamins in Cancer and Apoptosis. Philos Trans R Soc
Lond B Biol Sci 369: 20130096.
C) Contributions to books
1.
Greger, R. and K. Kunzelmann. Chloride transporting epithelia. In: Kinne, R. (ed) Basic
Principles in Transport. Comp. Physiol., Karger Basel, 1989, 84-114.
2.
Greger, R. and K. Kunzelmann. Properties and regulation of chloride and potassium
channels in cultured respiratory epithelial cells. In: Kaiser, D. (ed). Mukoviszidose:
Ergebnisse aus Grundlagenforschung und Klinik. Berlin, 1989, 79-83.
----------------------------------------------------------------------------------------------------------------------------3.
Greger, R., L. Gerlach, and K. Kunzelmann. Epithelial chloride channels. Properties and
regulation. In: Keeling, D., C. Benham (eds). Ion transport. Academic Press, London,
1990, 237-247.
4.
Greger, R. and K. Kunzelmann. Epithelial chloride channels. In Young, J. A., P. Y. D.
Wong (eds). Epithelial secretion of water and electrolytes. Springer, New York, 1990, 314.
5.
Greger, R., M. Tilmann, and K. Kunzelmann. Regulation of epithelial chloride channels.
In Wong, P. Y. D., J. A. Young (eds). Exocrine Secretion II. United League Graphic
Printing, Hong Kong, 1990, 61-64.
----------------------------------------------------------------------------------------------------------------------------6.
Greger, R., K. Kunzelmann, E. Lohrmann, and C. P. Hansen. Regulation of chloride
channels in HT29 cells. In: Murakami, M., Y. Seo, A. Kuwahara, H. Watari (eds). Ionic
Basis and energy metabolism of epithelial transport. Hot aspects from exocrine secretion.
Kebun Printing, Okazaki, 1991, 167-170.
17
7.
Greger, R., M. Tilmann, and K. Kunzelmann. Regulation des Elektrolyttransportes in
Epithelzellen der Luftwege. In: Döring, G. and D. Kaiser (eds). Mukoviszidose:
Ergebnisse aus Grundlagenforschung und Klinik. Berlin, 1991, 4-9.
8.
Kunzelmann, K., M. Tilmann, C. P. Hansen, and R. Greger. A cytosolic inhibitor of
chloride channels. In: Murakami, M., Y. Seo, A. Kuwahara, H. Watari (eds). Ionic basis
and energy metabolism of epithelial transport. Hot aspects from exocrine secretion.
Kebun Printing, Okazaki, 1991, 171-174.
9.
Kunzelmann, K., M. Tilmann, and R. Greger. Cytosolic inhibition and excision activation
of epithelial chloride channels. In: Tsui, L.-C., G. Romeo, R. Greger, S. Garini (eds). The
identification of the CF (Cystic Fibrosis) gene. Plenum Press., New York, 1991, 225-233.
----------------------------------------------------------------------------------------------------------------------------10. Kunzelmann, K., C. P. Hansen, M. Grolik, M. Tilmann, and R. Greger. Regulation of the
chloride conductance of colonic carcinoma cells. In: Hoiby, N. and S. S. Pedersen (eds).
Cystic Fibrosis: basic and clinical research. Elsevier, Amsterdam. 1992, 49-56.
11.
Tilmann, M., K. Kunzelmann, E. Lohrmann, Z. I. Cabantchik, and R. Greger. Exogenous
and endogenous blockers of epithelial chloride channels. In: Cabantchik, I. Z. and R.
Greger (eds). GIF-Publication, Jerusalem, 1992, 31-42.
----------------------------------------------------------------------------------------------------------------------------12. Kunzelmann, K., M. Tilmann, and R. Greger. Ion transport in HT29 colonic carcinoma
cells. In: Clauss, W., (ed). Advances in comparative and environmental physiology.
Springer, Berlin, Heidelberg, New York. 1993, 237-251.
----------------------------------------------------------------------------------------------------------------------------13. Greger, R. and K. Kunzelmann. Epithelialer Chloridtransport und Mukoviszidose. In:
Deutsche Akademie der Naturforscher Leopoldina, Acta Nova Leopoldina. Halle, 1995,
285-294.
----------------------------------------------------------------------------------------------------------------------------14. Greger, R., K. Kunzelmann, M. Bleich, and M. Mall. CFTR-regulator of epithelial ion
channels. In: Dinudom A. and Komwatana P. (eds). Studies in Honour of J.A.Young.
Sydney, 1996, 123-130.
----------------------------------------------------------------------------------------------------------------------------15. Kunzelmann, K. and R. Greger. CFTR, a regulator of ion channels. In: Deutsche
Akademie der Naturforscher Leopoldina. Nova Acta Leopoldina. Halle, 1997, 85-98.
16.
Schreiber, R., R. Greger, and K. Kunzelmann. Cystic fibrosis transmembrane
conductance regulator (CFTR) activates endogenous water permeability in Xenopus
oocytes. In: Deutsche Akademie der Naturforscher Leopoldina. Nova Acta Leopoldina.
Halle, 1997, 173-174.
----------------------------------------------------------------------------------------------------------------------------17. Kunzelmann, K. and R. Greger. Properties and function of CFTR. In: Current Drugs Ltd.
The Investigational Drugs Database. London, 1998, 67-79.
----------------------------------------------------------------------------------------------------------------------------18. Kunzelmann, K. Patch - Clamp Studien zur Charakterisierung der CFTR-Funktion. In:
Reinhardt D., G. M. K. R. S. M., (eds). Mukoviszidose. Springer Berlin/Heidelberg. 2001,
42-47.
Mall, M. and K. Kunzelmann. CFTR: A regulator of the amiloride - sensitive epithelial Na+
channel, ENaC. In: Cystic Fibrosis European Network. European Working Group on
CFTR Expression. Springer Berlin, 2001, 23-26.
-----------------------------------------------------------------------------------------------------------------------------
19.
18
20.
Kunzelmann, K. Control of membrane transport by the cystic fibrosis transmembrane
conductance regulator (CFTR). In: Kirk, K. L. and D. C. Dawson (eds). The Cystic
Fibrosis Transmembrane Conductance Regulator. Landes Bioscience USA, Kluwer
Academic / Plenum Publisher. 2003, 55-93.
----------------------------------------------------------------------------------------------------------------------------21. Kunzelmann K and Mall M (2009) Cystic Fibrosis. Encyclopedic Reference of Molecular
Mechanisms of Disease. Springer, Berlin 1: 1224.
----------------------------------------------------------------------------------------------------------------------------22. Kunzelmann K and Thews O (2010) Lungenatmung. In R.F. Schmidt, F. Lang, M.
Heckmann: Physiologie des Menschen. Springer Berlin/Heidelberg 30: 756-786.
----------------------------------------------------------------------------------------------------------------------------23. Amaral MD and Kunzelmann K (eds.) (2011) Cystic Fibrosis Diagnosis and protocols
Volume I: Approaches to study and correct CFTR defects. Methods in Molecular Biology
741
24.
Amaral MD and Kunzelmann K (eds.) (2011) Cystic Fibrosis Diagnosis and protocols
Volume II: Methods and Resources to Understand Cystic Fibrosis. Methods in Molecular
Biology 742
----------------------------------------------------------------------------------------------------------------------------25. Kunzelmann K and Thews O (2015) Lungenatmung. In R.F. Schmidt, F. Lang, M.
Heckmann: Physiologie des Menschen. In: Physiologie des Menschen (eds.R.F.Schmidt,
F.Lang, M.Heckmann).Berlin/Heidelberg: Springer 32: 756-786.
19