Pancreatic Cancer Research Research topic(s): Development of

Pancreatic Cancer Research Research topic(s): Development of

Pancreatic Cancer Research
Research topic(s):
Development of new concepts for diagnosis and therapy of pancreatic adenocarcinoma
Group leader(s):
Prof. Dr. phil. nat. Christian Pilarsky
Department of Visceral-, Thoracic- and Vascular Surgery
University Hospital Dresden
Fetscherstraße 74
01307 Dresden
Phone:
+49-351-458 7020
Fax:
+49-351-458 7338
E-mail:
[email protected]
Homepage: http://www.uniklinikum-dresden.de/das-klinikum/kliniken-poliklinikeninstitute/vtg/forschung/Forschungslabor
Education:
1983-1988
2005
Study of Biology in Frankfurt M. with grade "sehr gut"
Habilitation in Experimental Surgery at the University of Dresden
Training:
1990-1994
Doctoral thesis in Frankfurt M. with grade "magna cum laude"
Professional Appointments:
1993-1997
Group leader in the Dept. of Urology, University Dresden
1997-2002
Group leader at metaGen Pharmaceuticals
since 2002
Group leader in the Dept. of Surgery, University Dresden
Publications:
~110 scientific publications in peer reviewed journals
Funding:
Extrabudgetary funding by DFG, Deutsche Krebshilfe, SMWK, Wilhelm
Sander Stiftung
Journals:
Reviewer for Oncogene, Cancer Res., J Cell Mol. Med. and others
Grant review:
DFG, NIH
Prof. Dr. med. Robert Grützmann, MBA
Department of Visceral-, Thoracic- and Vascular Surgery
University Hospital Dresden
Fetscherstraße 74
01307 Dresden
Phone:
+49-351-458 2742
Fax:
+49-351-458 4395
E-mail:
[email protected]
Homepage: http://www.uniklinikum-dresden.de/das-klinikum/kliniken-poliklinikeninstitute/vtg/forschung/Forschungslabor
Education:
1988-1997
2005
2008-2011
Study of Medicine in Berlin
Habilitation in Surgery at the University of Dresden
Master in Health Care Management
Training:
1997-2002
Clinical training in surgery, University Dresden
Research Experience:
1995-1997
Doctoral thesis in Berlin
since 2002
Group leader together with PD Pilarsky in the Dept. of Surgery, University
Dresden
Professional Appointments:
1997
Visiting Associate Boston Consulting Group
1997-2006
Department of Surgery, University hospital Dresden
Since 2006
Group leader pancreatic surgery University hospital Dresden
2010
Professor of Surgery, University hospital Dresden
Publications:
~70 scientific publications in peer reviewed journals
Funding:
Extrabudgetary funding by DFG, Deutsche Krebshilfe
Awards:
von-Langenbeck-Preis der Deutschen Gesellschaft für Chirurgie 2005
Young Investigator Award: 11th Meeting of the International Association of
Pancreatology and the 35th Annual Meeting of the Japan Pancreas
Society 2004 (Sendai, Japan)
Journals:
Cancer Detection and Prevention; European Journal of Cancer;
Oncogene; Annals of Surgery, Cancer Research, GUT
Grant review:
Associazione Italiana per la Ricerca sul Cancro
Societies:
Association of Academic Surgery (USA), Deutsche Gesellschaft für
Allgemein und Viszeralchirurgie, Deutsche Gesellschaft für Chirurgie
(DGCH), Deutscher Pankreasclub, Mitteldeutsche Chirurgenvereinigung,
Pancreas Club (USA), Sektion Chirurgische Forschung der Deutschen
Gesellschaft für Chirurgie
Group members:
Scientists:
Dr. Marius Distler, Kristin Werner, Carolin Zimmermann
MD Students:
Nicole Samm, Petra Mattheschke, Iris Böhme, Katja Biewusch, Marie
Heyne, Maria Schneider, Vera Hentrich, Tobias Gorille
Internal collaborators:
Michael Bachmann, Institute of Immunology
Nils Cordes, Oncoray
Gustavo Baretton, Institute of Pathology
Michael Schröder, Institute for Bioinformatics
External collaborators:
Holger Kalthoff, Dept. of Molecular Oncology, University of Schleswig- Holstein
Glen Kristiansen, Institute of Pathology, University Bonn
Markus Büchler, Dept. of Surgery, University of Heidelberg
David Tuveson, Tumour Modelling & Experimental Medicine, Cold Spring Harbor Laboratory
Participation in collaborative research projects (local, national, international):
Roland-Ernst Stiftung für Gesundheitswesen: Gene expression profiling for the prediction of
pancreatic cancer patients survival (national)
Deutsche Forschungsgemeinschaft: The role of SFRP1 in pancreatic cancer metastasis
(national)
List of 10 most important publications 2005-2014:
1. Distler M, Kersting S, Niedergethmann M, Aust D, Franz M, Rückert F, Ehehalt F, Pilarsky
Ch, Post S, Saeger HD, Grützmann R (2013) Pathohistological Subtype predicts Survival in
Patients with Intraductal Papillary Mucinous Neoplasm (IPMN) of the Pancreas Ann Surg
258(2):324-30.
2. Overman MJ, Zhang J, Kopetz S, Davies M, Zhi-Qin J, Stemke-Hale K, Rummele P, Pilarsky
C, Grutzmann R, Hamilton S, Hwang R, Abbruzzese JL, Varadhachary G, Broom B, Wang H
(2013). "Gene expression profiling of ampullary carcinomas classifies ampullary carcinomas
into biliary-like and intestinal-like subtypes that are prognostic of outcome." PLoS One 8(6):
e65144.
3. Winter C, Kristiansen G, Kersting S, Roy J, Aust D, Knosel T, Rummele P, Jahnke B,
Hentrich V, Ruckert F, Niedergethmann M, Weichert W, Bahra M, Schlitt HJ, Settmacher U,
Friess H, Buchler M, Saeger HD, Schroeder M, Pilarsky C, Grutzmann R (2012). "Google
goes cancer: improving outcome prediction for cancer patients by network-based ranking of
marker genes." PLoS Comput Biol 8(5): e1002511.
4. Perez-Mancera PA, Rust AG, van der Weyden L, Kristiansen G, Li A, Sarver AL, Silverstein
KA, Grutzmann R, Aust D, Rummele P, Knosel T, Herd C, Stemple DL, Kettleborough R,
Brosnan JA, Li A, Morgan R, Knight S, Yu J, Stegeman S, Collier LS, ten Hoeve JJ, de
Ridder J, Klein AP, Goggins M, Hruban RH, Chang DK, Biankin AV, Grimmond SM,
Australian Pancreatic Cancer Genome I, Wessels LF, Wood SA, Iacobuzio-Donahue CA,
Pilarsky C, Largaespada DA, Adams DJ, Tuveson DA (2012). "The deubiquitinase USP9X
suppresses pancreatic ductal adenocarcinoma." Nature 486(7402): 266-270.
5. Ehehalt F, Rummele P, Kersting S, Lang-Schwarz C, Ruckert F, Hartmann A, Dietmaier W,
Terracciano L, Aust DE, Jahnke B, Saeger HD, Pilarsky C, Grutzmann R (2011).
"Hepatocyte nuclear factor (HNF) 4alpha expression distinguishes ampullary cancer
subtypes and prognosis after resection." Ann Surg 254(2): 302-310.
6. Ruckert F, Samm N, Lehner AK, Saeger HD, Grutzmann R, Pilarsky C (2010).
"Simultaneous gene silencing of Bcl-2, XIAP and Survivin re-sensitizes pancreatic cancer
cells towards apoptosis." BMC Cancer 10: 379.
7. Ruckert F, Dawelbait G, Winter C, Hartmann A, Denz A, Ammerpohl O, Schroeder M,
Schackert HK, Sipos B, Kloppel G, Kalthoff H, Saeger HD, Pilarsky C, Grutzmann R (2010).
"Examination of apoptosis signaling in pancreatic cancer by computational signal
transduction analysis." PLoS One 5(8): e12243.
8. Olive KP, Jacobetz MA, Davidson CJ, Gopinathan A, McIntyre D, Honess D, Madhu B,
Goldgraben MA, Caldwell ME, Allard D, Frese KK, Denicola G, Feig C, Combs C, Winter SP,
Ireland-Zecchini H, Reichelt S, Howat WJ, Chang A, Dhara M, Wang L, Ruckert F,
Grutzmann R, Pilarsky C, Izeradjene K, Hingorani SR, Huang P, Davies SE, Plunkett W,
Egorin M, Hruban RH, Whitebread N, McGovern K, Adams J, Iacobuzio-Donahue C, Griffiths
J, Tuveson DA (2009). "Inhibition of Hedgehog signaling enhances delivery of chemotherapy
in a mouse model of pancreatic cancer." Science 324(5933): 1457-1461.
9. Ruckert F, Hennig M, Petraki CD, Wehrum D, Distler M, Denz A, Schroder M, Dawelbait G,
Kalthoff H, Saeger HD, Diamandis EP, Pilarsky C, Grutzmann R (2008). "Co-expression of
KLK6 and KLK10 as prognostic factors for survival in pancreatic ductal adenocarcinoma." Br
J Cancer 99(9): 1484-1492.
10. Pilarsky C, Ammerpohl O, Sipos B, Dahl E, Hartmann A, Wellmann A, Braunschweig T, Lohr
M, Jesenofsky R, Friess H, Wente MN, Kristiansen G, Jahnke B, Denz A, Ruckert F,
Schackert HK, Kloppel G, Kalthoff H, Saeger HD, Grutzmann R (2008). "Activation of Wnt
signalling in stroma from pancreatic cancer identified by gene expression profiling." J Cell
Mol Med 12(6B): 2823-2835.
11. Kristiansen G, Jacob J, Buckendahl AC, Grutzmann R, Alldinger I, Sipos B, Kloppel G, Bahra
M, Langrehr JM, Neuhaus P, Dietel M, Pilarsky C (2006). "Peroxisome proliferator-activated
receptor gamma is highly expressed in pancreatic cancer and is associated with shorter
overall survival times." Clin Cancer Res 12(21): 6444-6451.