Complete Program

Transcrição

Complete Program

2015
Science-Industry-Symposium
NanoVision
// Program
// November 17th – 18th 2015
// Fraunhofer Institute for Integrated Systems and
Device Technology IISB
Quelle: EAM-CENEM
Quelle: KIT
Quelle: BASF
Quelle: EMPA
Quelle: EAM-CENEM
// Hans-Georg-Waeber-Saal, Schottkystraße 10,
91058 Erlangen, Germany
Program Overview
Tuesday, November 17th 2015
08:30 Registration, Meet & Greet
09:00 Welcome Notes
Wolfgang Peukert (FAU), Jasmin Aghassi (NanoMat)
Characterization I
09:15 Functional particle systems in 5 dimensions – Size, shape, surface,
structure and composition
Wolfgang Peukert (FAU)
09:40 NanoBioAnalysis – Pushing the Frontiers in Münster: EU-NCL and NCL-Münster
Birgit Hagenhoff (Pushing the frontiers in Münster: Tascon GmbH, Münster)
10:05 Micro- and nanostructure of energy materials – 2D, 3D and in-situ
characterization
Christian Kübel (KIT)
10:30 Coffee Break
Nanomedicine I
10:45 Innovative applications of magnetic nanoparticles in medicine –
The SEON concept
Christoph Alexiou (Uniklinik Erlangen)
11:10 Multifunctional nanoparticles for medical diagnostics
Jörn Probst (Fraunhofer ISC)
11:35 The relevance of the biomolecule corona for nanomedicine and nanosafety
Roland Stauber (Universität Mainz)
Catalysis I
12:00 Nanostructures can enable fossil energy-free future (power-to-gas to-fuel)
while conserving resources (making more with less)
Henning Zoz (Zoz Group)
12:25 Posters & Lunch
Catalysis I (cont.)
13:30 Hydrogen storage via liquid organic hydrogen compounds – From catalyst
materials to process design
Peter Wasserscheid (FAU)
13:55 Commercial hydrogen storage and logistics based on liquid organic
hydrogen carriers
Berthold Melcher (Hydrogenious Technologies GmbH)
14:20 Eco-friendly fabrication of polymer solar cells using organic nanoparticle
dispersions
Alexander Colsmann (KIT)
14:45 Coffee Break
Characterization II
15:00 Nanoscale characterization of materials by advanced transmission
electron microscopy
Erdmann Spiecker (FAU)
15:25 Electrical surface characterization of modern nano devices
Wolfgang Mertin (Universität Duisburg-Essen)
15:50 What’s nano got to do with it? The importance of material characterization
for nanosafety
Clarissa Marquardt (KIT)
16:15 Fluoreszenz und Magnetismus in Abhängigkeit von Struktur, Größe und Form
von Nanopartikeln – Bedeutung für Anwendungen in Nanomedizin und
Optoelektronik
Jan Niehaus (Can GmbH)
16:40 Break
Nanomedicine II
17:00 Nanosilber-Systemtechnologie im medizinischen Umfeld
Helmut Schmid (Fraunhofer ICT)
17:25 Nanomedicine: principles, progress and perspectives
Twan Lammers (Uniklinik Aachen)
17:50 Hybrid organosilica material for biomedical applications
Eko Adi Prasetyanto (Université de Strasbourg)
18:15 Dinner & Posters
Wednesday, November 18th 2015
Characterization III
08:30 In-situ sedimentation analysis: New possibilities of particle characterization by
means of analytical ultracentrifugation
Johannes Walter (FAU)
08:55 AFM characterization in biomedical and green energy research
Hartmut Stadler (Bruker BNS)
09:20 Helium ion microscopy – A new tool for imaging at the nanoscale
Ruth Schwaiger (KIT)
9:45
Coffee Break
Catalysis II
10:00 Oxide-nanotube arrays for solar energy conversion
Patrik Schmuki (FAU)
10:25 Perspectives of artificial leafs for solar fuel generation: Physical boundary
conditions and material science challenges
Wolfram Jaegermann (TU Darmstadt)
10:50 Highly efficient thin film solar cells – How nano-structuring can help to improve
the performance further
Stephan Bücheler (Empa, Dübendorf)
11:15 Coffee Break
Perspectives
11:30 Neue Themen und Strukturen in der NanoBioMedizin
Klaus-Michael Weltring (Gesellschaft für Bioanalytik Münster e.V.)
12:00 Integration von Nanostrukturen im Materialsystem: Entscheidender Wert der
Charakterisierung
Martin Strohrmann (BASF SE)
12:30 Stabilisierung von photokatalytischen Nanopartikelstrukturen für
Hochtemperaturanwendungen
Alfred Weber (TU Clausthal)
13:00 Closing remarks
Jasmin Aghassi (NanoMat)
13:05 Lunch
Lectures
Tuesday, November 17th 2015, 09:15
Functional particle systems in 5 dimensions – Size, shape, surface,
structure and composition
Prof. Dr. Wolfgang Peukert
Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
[email protected]
Today, an important worldwide trend in particle technology is the requirement to
understand systems of ever increasing complexity. Available techniques for particle
characterization are predominantly focused on size characterization, even simultaneous
size and shape characterization is still an unresolved major challenge. Beyond size, also
shape, particle surface, composition and the particle’s inner structure also come into
focus. These structural features are closely related to biological, chemical, electronic,
mechanical and optical properties of the particles opening vast opportunities in many
fields of application including nanoelectronics, photonics, energy conversion and
storage and the life sciences. The grand challenge is to design particle systems with
specific and well understood functionalities and to transfer these systems to real world
applications. Efficient and economical production of these particle systems inevitably
requires the ability to characterize systems that display distributions in all properties.
Novel approaches are presented which give access to information beyond size. Particle
surfaces are characterized by means of nonlinear spectroscopy (second harmonic
generation and sum frequency generation) allowing fast optical access to particle
surface properties in liquids including charge and adsorbed molecules. The only known
technique which is capable of multidimensional particle characterization is analytical
ultracentrifugation equipped with novel inline multiwavelength absorption optics. Size,
shape or spectral information are accessible simultaneously, thus largely expanding the
capabilities of AUC for multidimensional particle analysis over a broad particle size range from below a nanometer to several microns. Least known is the “universe inside”,
i.e. is the internal particle structure including local composition and structural defects.
Recent results by means of high resolution SEM/TEM-based nanomechanics coupled
with RAMAN spectroscopy shed light on this rapidly evolving field of nanostructural
and nanomechanical effects in particles.
References:
Sauerbeck C., Braunschweig B., Peukert W., Surface charging and interfacial water structure of amphoteric
colloidal particles, J. Phys. Chem. C 118 (2014) 10033-10042
Walter J., Sherwood P.J., Lin W., Segets D., Stafford W.J, Peukert W., Simultaneous analysis of hydrodynamic
and optical properties using analytical ultracentrifugation equipped with multiwavelength detection, Anal.
Chem. 87 (2015) 6, 3396-3403
Romeis, S., Paul J, Herre P., de Ligny D., Schmidt J., Peukert W., Local densification of a single micron sized silica
sphere by uniaxial compression, Script. Mater. 108 (2015) 84-87
NanoBioAnalysis – Pushing the frontiers in Münster: EU-NCL and NCLMünster
Dr. Birgit Hagenhoff
Tascon GmbH, Münster
[email protected]
The recent years have seen an increasing use of nanomaterials, in particular nanoparticles. Applications include sun protection, optimization of the hydrophobicity of shoes
and antimicrobial composition of stockings and refrigerators.
With the increase in routine application, however, the emission of nanoparticles into
the environment increases with increasing the risk of unwanted health effects. These
questions have also been recently addressed by the EU regulation authorities.
In Münster, traditionally strong in surface and nanoanalysis, a new option for the
characterisation of nanoparticles and nanoparticle containing products has now
become available: the NCL (nano characterisation laboratory)-Muenster. It consists of a
networking and co-operating group of research organizations and dedicated SMEs. It
allows to address the complete analytical value added chain for the characterisation of
nanomaterials:
•
physical and chemical characterisation
•
in-vitro assays
•
in-vivo assays
The NCL-Münster partners are also included in the EU-project EU-NCL which aims at
the development of test assemblies suited for the evaluation of industry materials in
the regulation context.
The talk will introduce the infrastructure context of both institutions and present some
applications.
Micro- and nanostructure of energy materials – 2D, 3D and in-situ
characterization
Dr. Christian Kübel
Institute of Nanotechnology, Karlsruhe Institute of Technology (KIT)
[email protected]
Modern electron microscopic methods are an essential tool to characterize materials
from the atomic to the micron scale, both the 2D and 3D structure, to help understand
the correlation between synthesis/processing and materials properties. Furthermore,
over the last couple years, in-situ techniques have been increasingly established to provide a more direct look at the fundamental processes in materials by directly imaging
structural changes due to an external stimulus.
In this presentation, I will introduce some of the recent developments in high-end TEM
characterization such as electron tomography, automated crystal orientation mapping
and in-situ techniques in addition to classical high-resolution imaging. Using battery
materials/systems and catalyst materials as examples, I will illustrate the potential the
techniques offer for various aspects of structural characterization to provide information on the processes during electrochemical biasing and for tuning meso-/macroporous
supports in catalysis.
Innovative applications of magnetic nanoparticles in medicine –
The SEON concept
Prof. Dr. Christoph Alexiou
Department of Otorhinolaryngology, University Hospital Erlangen
[email protected]
The application of nanotechnology in medicine is an interdisciplinary area of research
in science, engineering and medicine with broad application for imaging, molecular
diagnosis and targeted therapy. In particular superparamagnetic iron oxide nanoparticles (SPIONS) deserve attention as they can be used for diagnostic as well as for therapy
(“theranostics”). For diagnosis in vivo SPION are already in use as contrast agents in
magnetic resonance imaging, in vitro they are appointed for cell separation.
From a drug delivery point of view, targeting diseases (i.e. cancer, atherosclerosis) is
a most promising area concerning delivery of therapeutic agents. A very promising
approach in this field is Magnetic Drug Targeting (MDT), which enables a goal oriented
local application of therapeutics in the desired region and successful animal experiences have been performed on this topic. SEON (Section of Experimental Oncology and
Nanomedicine) is aiming to translate this efficient therapeutic model into clinical trials.
Multifunctional nanoparticles for medical diagnostics
Dr. Jörn Probst
Business Unit Health, Fraunhofer ISC, Würzburg
[email protected]
Monodisperse luminescent hybrid NPs can be synthesized by sol-gel technology and
labelled with conventional organic dyes. Dye molecules are incorporated homogeneously into the silica matrix by covalent attachment. In consequence, the hybrid NPs
show significant resistance to photobleaching and dye leakage. But the use of such
material systems is limited by the availability of organic fluorophores for NP labelling in
the required range region and by the compatibility of the dye-matrix system.
An alternative is to use inorganic NPs. They exhibit superior properties, such as
structure and material-dependent optical properties, and a negligible effect of
photobleaching. Like hybrid NPs, luminescent inorganic NPs can also be obtained by
wet-chemical methods, e.g. by precipitation or a modified Pechini sol-gel process. The
structure, size, and composition of these NPs can easily be controlled to tailor their
chemical and physical properties. Depending on the synthesis conditions and further
application, they exhibit various compositions and structures: hybrid crystals or core/
shell structured NP systems. Typical materials for NP matrices are zinc silicate, calcium
phosphate or calcium fluoride. These inorganic materials can be doped with various
lanthanide ions that lead to paramagnetism, fluorescence, and X-ray opacity and make
them suitable for magnetic resonance imaging (MRI), fluorescence (PL) microscopy, and
X-ray imaging. The influence of the NP composition and structure is studied by optical
absorption, photoluminescence spectroscopy, and MRI. Further characterization is done
by conventional methods such as dynamic light scattering (DLS), transmission electron
microscopy (TEM) or X-ray diffraction analysis (XRD).
The resulting NPs are subsequently modified with various chemical functionalities such
as amine and carboxyl functions, using conventional functionalization methods such
as silanization. Furthermore, surface modified NPs are covalently attached to biological
moieties, e.g. antibodies, nucleobases, or peptides, by means of standard bioconjugation methods. Labelled multifunctional NP demonstrated their great application potential in the field of biological and medical diagnostics, e.g. in immunodetection assays.
The relevance of the biomolecule corona for nanomedicine and
nanosafety
Dr. Roland H. Stauber
Molecular and Cellular Oncology/Mainz Screening Center, University Hospital of Mainz
[email protected]
Besides the wide use of engineered nanomaterials (NM) in technical products, their
applications are increasing in biotechnology and biomedicine. Whereas the physicochemical properties and behaviour of NM can be characterized accurately under idealized conditions, this is no longer the case in complex physiological or natural environments. Here, proteins and other biomolecules rapidly bind to NM, forming the protein/
biomolecule corona critically affecting the NM’ (patho)biological and technical identity.
As the corona impacts in vitro and/or in vivo NM applications in humans, a mechanistic
understanding of its relevance and the biophysical forces regulating corona formation
is mandatory.
Based on recent insights, we here critically present an updated concept of corona
formation and evolution. We comment on how corona signatures may be linked to
effects at the nano-bio interface in physiological and environmental systems. In order
to comprehensively analyse corona profiles and to mechanistically understand the coronas’ biological impact, we present a tiered multidisciplinary approach. To stimulate progress in the field, we introduce the impact of the corona for NM-microbiome-(human)
host interactions and the novel concept of ‘nanologicals’, i.e., the nanomaterial-specific targeting of molecular machines. We conclude by discussing relevant challenges,
which need to be resolved by the field.
References:
Docter D, et al. and Stauber RH. Chem. Soc. Rev. 44 (2015) 6094
Docter D, et al. and Stauber RH. Nat. Protocols 9 (2014) 2030
Tenzer, S., et al. and Stauber RH. Nat. Nanotechnol. 8 (2013) 772
Helou, M. et al. Lab Chip 13 (2013) 1035
Nanostructures can enable fossil energy-free future (Power to Gas to
Fuel) while conserving resources (making More with Less)
Prof. Dr. Henning Zoz
Zoz Group
[email protected]
Zoz is an equipment manufacturer for making nanostructured materials in large
volume with the aim to achieve more materials function with less material investment.
This can be super light-weight (Zentallium®) or better magnetic materials (Zoz-NdFeB),
better concrete (FuturBeton), and better energy storage materials, for either electrochemical (ZoLiBat®) or solid state hydrogen storage (Hydrolium®).
For the latter, the quickly replaceable hydrogen-tanks H2Tank2Go® carrying nanostructured solid-state-absorber Hydrolium®, strategy and claim for a potential revolution of
the refueling-infrastructure “on road” and the “Zoz Power-to-Gas-to-Fuel”-scenario
could represent a key mark for the German “Energiewende”. Bringing H2Tank2Go®
in the air is expected to triple the range of the Icaré-Solar-Airplane, demonstrating
self-sustaining "hydrogen flight" and simple infrastructure of tank-vending-machines
(replacement e. g. any home depot).
The Zoz-ZEV-Fleet (at present 10 ZE passenger cars/vans) showcases battery-electrified
mobility, a representative fleet utilization and infrastructure evolution in a sophisticated
partner group. In the future, the "iron bird" (H2-energy-platform) from H2-OnAir shall
be transferred to all vehicles offering the first chance ever for local private passenger
transportation powered by hydrogen. The economic heart of the "iron bird" is a cost
effective PEMFC reduced to the minimal electrical power scale.
The Zoz-ZEV-Fleet is representing the part "to Fuel" and is organized in the so called
"Blue Oasis Sauer-/Siegerland", the part "Power to Gas" is materialized at the Zoz
Technology Center at Olpe/Sauerland with a 0.2 MW PV-plant and a 40 kW McPhy
electrolyzer, also located in the heart of Germany.
These strategies constitute a technology bridge into the fossil fuel/energy-free future.
Hydrogen storage via liquid organic hydrogen compounds –
from catalyst materials to process design
Prof. Dr. Peter Wasserscheid
Lehrstuhl für Chemische Reaktionstechnik
Friedrich-Alexander-Universität Erlangen-Nürnberg
[email protected]
Hydrogen is often considered a very capable future energy vector. It can be produced
from renewable wind or solar power via water electrolysis and has applications in
many fields of energy supply and as valuable chemical. The gravimetric energy storage
density of hydrogen is excellent (33.3 kWh (LHV) kg(H2) 1). However, its volumetric
storage density is only 3 Wh/liter at ambient pressure. In existing technical applications
hydrogen is therefore either stored under very high pressures (up to 700 bar) or in its
liquid state at 253 °C to reach acceptable storage densities.
A very attractive way to store and release hydrogen is in form of “Liquid Organic
Hydrogen Carriers” (LOHC) systems. Aromatic molecules, such as e.g. N-ethylcarbazole
(NEC) [1] or dibenzyltoluenes [2], can be reversibly hydrogenated and dehydrogenated
in order to store and transport large amounts of hydrogen in form of diesel-like liquids.
The presentation introduces shortly the LOHC concept for energy storage and future
hydrogen logistics. Afterwards it concentrates on reaction engineering challenges of
the catalytic LOHC dehydrogenation process that represents the key step regarding the
efficiency and robustness of the overall storage process. Macrokinetic effects at the
porous dehydrogenation catalyst [3] and different reactor designs to handle gas evolution and endothermicity of the reaction will be presented [4]. The potential of additive
manufacturing (“3D-printing”) of the dehydrogenation reactor will be discussed.
[1] D. Teichmann, W. Arlt, P. Wasserscheid, R. Freymann, Energy & Environmental Science 2011, 4(8),
2767-2773.
[2] N. Brückner, K. Obesser, A. Bösmann, D. Teichmann, W. Arlt, J. Dungs, P. Wasserscheid, ChemSusChem
2014, 7(1), 229-235.
[3] W. Peters, A. Seidel, S. Herzog, A. Bösmann, W. Schwieger, P. Wasserscheid, Energy & Environmental
Science, 2015, Energy & Environmental Science, 2015, 8, 3013 – 3021.
[4] W. Peters, M. Eypasch, T. Frank, J. Schwerdtfeger, C. Körner, A. Bösmann, P. Wasserscheid, Energy &
Environmental Science, 2015, 8, 641–649.
Commercial hydrogen storage and logistics based on liquid organic
hydrogen carriers
Dr. Bertold Melcher
Hydrogenious Technologies GmbH
[email protected]
In a world with an increasing percentage of fluctuating renewable electricity generation the demand for high capacity storage solutions becomes obvious. Hydrogen is
widely perceived as energy vector of the future. It can be generated from electricity
via electrolysis and also directly from renewable ressources by different methods. And
hydrogen can be transformed back to electricity by various means and even used as a
substance of value.Thus hydrogen is a versatile compound in todays and in an upcoming energy environment.
Storage of hydrogen however is not as easy as it should be for a large scale and widely
distributed application. Both, pressurized and cryogenic storage, bear difficulties that
prevent a broad penetration of the market. Here Liquid Organic Hydrogen Carriers
(LOHC) offer an elegant solution. With a storage density of roughly 2 kWh/kg and the
perspective that well known and accepted infrastructures of our todays oil based energy distribution system can be used, LOHC offers a solution to a facile and save high
density hydrogen storage and handling.
Within the presentation the chemical principles will be explained, the origin of the
technological development and comparisions will be made with other storage technologies. Besides energy storage also the applicability for hydrogen logistics will be
shown.
Hydrogenious Technologies GmbH is a spin-off of the University of Erlangen-Nuremberg (FAU). Founded in 2013 by CEO Dr. Daniel Teichmann and the three FAU professors Wasserscheid, Arlt and Schlücker, the company has now 17 employees and is
working on the commercialization of the LOHC technology as the standard for long
term energy storage based on hydrogen and hydrogen logistics.
Eco-friendly fabrication of polymer solar cells using organic
nanoparticle dispersions
Dr. Alexander Colsmann
Light Technology Institute, Karlsruhe Institute of Technology (KIT)
[email protected]
The industrial fabrication of organic solar cells is often hampered by toxic solvents that
require strong safety precautions. In this work, we fabricate organic solar cells utilizing
aqueous and alcoholic solutions. For the absorber layer, we disperse, investigate and
use P3HT:ICBA nanoparticles in environmentally friendly dispersion agents such as
ethanol. For the preparation of the dispersions, we intentionally omitted any stabilizers
that otherwise remain in the active layer, negatively affecting the device performance.
In an inverted solar cell architecture comprising a nanoparticulate P3HT:ICBA layer,
the power conversion efficiency exceeds 4% and hence matches the performance of
reference devices that were fabricated from dichlorobenzene. Atomic force microscope
images of the P3HT:ICBA surface visualize the merging of the nanoparticles upon thermal annealing. Irradiation intensity dependent current measurements show a gradual
change from bimolecular recombination towards monomolecular recombination at
higher annealing temperatures within the bulk-heterojunction. The universality of this
approach allows the use of other common organic photo active materials for the fabrication of solution processable organic solar cells from non-hazardous solvents.
References:
S. Gärtner, M. Christmann, S. Sankaran, H. Röhm, E.-M. Prinz, F. Penth, A. Pütz, E. Türeli, B. Penth, B. Baumstümmler, A. Colsmann, Adv. Mater. 26 (2014) 6653–6657
S. Sankaran, K. Glaser, S. Gärtner, T. Rödlmeier, K. Sudau, G. Hernandez Sosa, A. Colsmann, Org. Electronics,
2015, doi:10.1016/j.orgel.2015.10.011
Nanoscale characterization of materials by advanced transmission
electron microscopy
Prof. Dr. Erdmann Spiecker
[email protected]
Transmission electron microscopy has established itself as the most powerful and
versatile tool for studying materials on the nanometer and atomic scale. A variety of
techniques can be combined to gain deep insight into the inner structure and chemical composition of materials, including high resolution imaging (HRTEM, HRSTEM),
analytical techniques (EELS, EFTEM) as well as 3D analysis (electron tomography). These
techniques become particularly powerful in combination with site-specific sample preparation and manipulation enabled by FIB-SEM technology. Moreover, recent developments in in situ TEM techniques enable direct observation of material processes as well
as measurement of material properties on small length scales.
In this contribution examples of advanced TEM studies in projects of the DFG funded
Cluster of Excellence EXC 315 “Engineering of Advanced Materials“ and Research Training Group GRK 1896 “In situ microscopy with electrons, X-rays and scanning probes”
will be presented.
Electrical interface characterization of modern nano devices
Dr. Wolfgang Mertin
Universität Duisburg-Essen
[email protected]
Novel nanomaterials, such as 2-dimensional materials or 1-dimensional nanowires
allow new device concepts in electronics and optoelectronics. Common to all such devices are interfaces like electrical contacts, doping or heterostructure transitions, which
fundamentally affect the device performance and thus require a detailed control and
understanding of interfaces on the nanoscale.
We address this issue for selected nanoscale devices by combining Kelvin probe force
microscopy (KPFM) and micro-optical measurements. In a single GaAs nanowire, the
axial doping transition could be localized by KPFM with an accuracy below 50 nm and
photogeneration of charge carriers is found to take place only in the vicinity of the pnjunction. By locally recording contact and sheet resistances in functionalized graphene
sheets we identified a change of the transport mechanism from hopping to diffusive
going along with a change from a Schottky-type contact to a nearly non-invasive
metal-metal one if the C/O ratio is varied. In a transistor made of CVD graphene, we
found that devices fabricated by optical lithography have a significantly larger contact
resistance than devices produced by electron beam lithography. This difference is attributed to a 3 – 4 nm thick residual layer remaining in-between the contact metal and
the graphene after optical lithography.
What’s nano got to do with it? The importance of material
characterization for nanosafety
Dr. Clarissa Marquardt
Institute for Applied Computer Science (IAI), Karlsruhe Institute of Technology
[email protected]
Nanotechnology is having a great impact not only on basic research but also on many
sectors of industry opening the market for numerous new applications ranging from
electronics to the health care system. Besides their great innovative potential, the
large variety of existing synthetic nanomaterials used in the last decade represents a
major challenge for scientists and regulators in terms of measuring and assessing the
potential hazard caused by the materials or the products themselves. Nanomaterials
are available in various modifications (shape, size, chemical composition, surface functionalisation,..), which greatly influence their behaviour in a certain system (products,
humans, environment). Therefore, a thorough and comprehensive characterization of
the nanomaterials itself and in the respective setting is an absolute necessity for future
usage for safety assessment and regulatory issues.
The DaNa2.0 project (Data and knowledge on nanomaterials, www.nanopartikel.
info) has therefore created a Literature Criteria Checklist with mandatory and desirable
assessment criteria covering the topics physico-chemical characterisation, sample preparation and necessary testing parameters ensuring the quality of information provided
by scientific publications. All positively evaluated literature is then processed by an
international team of experts and fed into the DaNa knowledge base, a web-platform
that offers easy-to-understand, up-to-date and quality-approved information on 25
market-relevant nanomaterials concerning their effects on safety of humans and the
environment.
Fluoreszenz und Magnetismus in Abhängigkeit von Struktur, Größe
und Form von Nanopartikeln – Bedeutung für Anwendungen in Nanomedizin und Optoelektronik
Dr. Jan Niehaus
Can GmbH
[email protected]
Die CAN GmbH beschäftigt sich seit ihrer Gründung vor 10 Jahren mit der kolloidalen
Synthese von hochqualitativen Nanopartikeln. Hierbei werden unterschiedlichste Systeme wie Halbleiter, Metalle sowie deren Oxide hergestellt. Mittels CANs kontinuierlicher
Syntheseplattform CANflow lassen sich diese Partikel in unterschiedlichen Größen,
Partikelformen und –strukturen gezielt reproduzierbar synthetisieren. Ebenso entscheidend wie die Synthese ist jedoch auch die zuverlässige Charaketerisierung entscheidender Schlüsseleigenschaften.
Innerhalb dieses Workshops möchten wir daher zum einen das Thema Konzentrationsbestimmung von Nanopartikeln behandeln. Eine besondere Herausforderung ist
es, bei unterschiedlichsten Partikeln eine vergleichbare Konzentration zu bestimmen.
Hierzu ist auch eine präzise Bestimmung der Größe und Verteilung der verschiedenen
Partikeltypen notwendig.
Zweites Thema ist die Messung der Fluoreszenz von Quantum Dots und Rods. Neben
der relativ simplen Messung im vis soll hier zudem Messungen im IR und vor allem die
Bestimmung der Quantenausbeute sowie die Probleme bei der Vergleichbarkeit dieser
Werte erläutert werden. Die Bestimmung dieser Eigenschaften ist von besonderer
Bedeutung für Anwendungen in der Optoelektronik.
Zum Schluss soll noch auf die Bestimmung der magnetischen Eigenschaften von
Eisenoxid-Nanopartikeln eingegangen werden. Hier wird der Schwerpunkt auf der
Bestimmung der Relaxivitäten für Anwendungen aus Kontrastmittel in der Nanomedizin liegen.
Nanosilber-Systemtechnologie im medizinischen Umfeld
Helmut Schmid
Fraunhofer-Institut für Chemische Technologie, Pfinztal
[email protected]
Nanotechnology can be used in medicine in many aspects: In the medical research,
drug discovery and the analysis of cell-signaling pathways are in the foreground. In
therapy, targeted drug release, gene-availability, personalized medicine, regenerative
medicine (bioactive surfaces), tissue engineering, antimicrobial surfaces and cancer
therapy are important keywords. In diagnostics, the themes biosensors, biochips (DNA,
proteins, cells) and medical imaging are significant.
For these applications, the Fraunhofer ICT developed diverse nano products in form of
nano-ingredients combined with biocompatible liquids or polymer binders. However, it
should be noted that for applications in and on humans, the intended effect and the
nontoxicity must be proven through a prescribed series of in vitro and in vivo experiments – followed by time – and cost-intensive approval process.
The question arises to what extent nanotechnology can be used innovatively in medical
environments. Here, the term "innovation" is defined by the following requirements:
(i) Product not "nice to have", but real problem solver with unique selling features, (ii)
no linear improvement of an existing system, but benefits in terms of a step function,
(iii) no human toxicity and negative environmental impact, (iv) sustainability of action,
(v) large-scale manufacturability, (vi) marketable price, (vii) partner involvement with
marketing experience, distribution network and market access.
Multi-resistant bacteria in hospitals are a real threat. The fact that every day about 300
people worldwide die from such infections, shows the problem. To raise awareness,
one can think about the number of victims of a daily plane crash. Under these circumstances, this kind of transportation would be probably no longer used by most people.
As state-of-the-art in hospitals antimicrobial surfaces - on a larger scale - are either not
established, or based on toxic standard biocides. To solve this problem, nanosilver system technology has been developed for providing antimicrobial surfaces in hospitals.
The system has now been tested in practice for 10 years with regard to efficacy and
safety and is used around the world.
The presentation explains the initial situation, describes the methodology and presents
selected results of nanosilver system technology.
Nanomedicine: principles, progress and perspectives
Prof. Dr. Dr. Twan Lammers
Dept. of Nanomedicine and Theranostics, RWTH Aachen
[email protected]
Nanomedicine deals with 1-100(0) nm-sized carrier materials designed to improve the
biodistribution of systemically administered (chemo-) therapeutic drugs. By delivering
drug molecules more efficiently to pathological sites, and by preventing them from
accumulating in potentially endangered healthy tissues, nanomedicines are able to
beneficially affect the balance between efficacy and toxicity. Nanomedicines primarily
rely on the Enhanced Permeability and Retention (EPR) effect for efficient target site
accumulation, which is notoriously known to be highly variable, both in animal models
and in patients. To address this high variability in EPR, and to improve the (pre-) clinical
performance of nanomedicine formulations, we are working on strategies to modulate, combine, bypass and image EPR. In the present lecture, several of these approaches will be highlighted, focusing particularly on the use of nanotheranostics, which
combine diagnostic and therapeutic properties within a single formulation, and which
hold significant potential for individualizing and improving tumor-targeted nanomedicine treatments.
Hybrid organosilica material for biomedical applications
Dr. Eko Adi Prasetyanto
Institut de Science et d'Ingénierie Supramoléculaires, Université de Strasbourg
[email protected]
The use of silica based nanomaterials for biomedical application for drug delivery system is an intensely investigated field of research. In particular the appealing multifunctionality that can be built in a single nanoparticle is a fascinating development.
In contrast with the use of conventional porous silica materials, we developed hybrid
organosilica system by incorporating physiologically responsive functional groups in the
framework. Following this approach, it is possible to design a drug delivery platform,
which able to break apart after reaching the target cell. Furthermore, after release the
cargo payload, we could expect the remaining materials leave the cells and eventually
the body in the case of in vivo delivery.
Acknowledgements
We acknowledge financial support from the European Research Council for ERC
Advanced Grant (Grant Agreement no. 2009-247365) and Fondation ARC project
“Thera-HCC” grant IHU201301187.
Wednesday, November 18th 2015, 8:30
In-situ sedimentation analysis: new possibilities of particle characterization by means of analytical ultracentrifugation
Johannes Walter
[email protected]
The knowledge about the size, shape and optical properties of nanoparticles is of
high importance for many processes since product properties are directly influenced
by these parameters. In our talk it will be demonstrated that analytical ultracentrifugation equipped with an UV-Vis multiwavelength detector (MWL-AUC) is a powerful
tool for the multidimensional analysis of nanoparticles. MWL-AUC combines in-situ
UV-Vis spectroscopy and the fractionation of particles in a gravitational field with up
to 250,000 g. Our developments on the instrumentation, acquisition and evaluation
of MWL-AUC data allow us to significantly extend the possibilities of multidimensional
particle characterization.
Particle size distributions can be derived and linked for all species in a mixture to the
optical properties without the necessity of doing any purification step beforehand.[1,2]
Moreover, software for high dynamic range particle size evaluation of speed ramp experiments was developed utilizing the unique size and wavelength dependency of scattering. For platelets a methodology was derived to determine the lateral size distribution directly in solution with high accuracy and low experimental effort.[3,4] For carbon
nanotubes produced in a fluidized bed reactor the high yield and good dispersibility
could be proven.[5] For carbon nanodots studies revealing their surprisingly narrow sub
1 nm size were conducted.[6]
References:
[1] J. Walter, K. Löhr, E. Karabudak, et al., ACS Nano 8 (2014) 8871-8886
[2] J. Walter, P. J. Sherwood, W. Lin, et al., Anal. Chem. 87 (2015) 3396-3403
[3] J. Walter, T. J. Nacken, C. Damm, et al., Small 11 (2015) 814-825
[4] C. H. Halbig, T. J. Nacken, J. Walter, et al., Carbon 96 (2016) 897-903
[5] F. Toni, H. Xing, J. Walter, et. al., Chem. Eng. Sci. 138 (2015) 385-395
[6] V. Strauss, J. T. Margraf, C. Dolle, et al., J. Am. Chem. Soc. 136 (2014) 17308-17316
AFM characterization in biomedical and green energy research
Dr. Hartmut Stadler
Bruker Nano Surfaces Divison, Karlsruhe
[email protected]
Modern material and life science on complex functional nanostructured surfaces
requires analytical techniques with sufficient resolution and correlated multimodal data
output. New AFM-imaging modes based on the direct, true pN-level force-control with
intelligent and ultrafast extraction of the complete tip-surface interaction cycles (Peak
Force Tapping Mode) have scientifically proven to be a very powerful technique for this
purpose. Multi-component surfaces can be non-destructively imaged with up to atomic
resolution in their natural environment. Fully correlated topographic and quantitative nanomechanical information can be extracted (Peak Force QNM). Simultaneous
detection of conductivity and charge distribution adds nanoelectrical properties to the
data set (Peak Force TUNA/KPFM). Recent extensions of the Peak Force Tapping family
combine optical nearfield detection with force based imaging and crosslink nanoelectromechanical measurements with nm-resolved chemical identification (Peak Force
IR). History, realization and implications of these exciting new imaging modalities will
be discussed and highlighted with application examples from biomedical and green
energy research.
Helium Ion Microscopy – A new tool for imaging at the nanoscale
Dr. Ruth Schwaiger
Institute for Applied Materials (IAM) and Karlsruhe Nano Micro Facility (KNMF),
Karlsruhe Institute of Technology
[email protected]
Helium ion microcopy represents a new high resolution microscopy and nanofabrication technique. The focused helium ion beam facilitates high-resolution imaging with
high surface sensitivity and a depth-of-field 5-10 times higher than in a modern field
emission scanning electron microscope. The helium ion microscope is well suited to
imaging challenging samples such as polymer-based systems and biological specimens
without additional sample coating. For electrically insulating samples, positive charge
resulting from the ion beam is compensated by using an electron flood gun directed
at the sample. The helium ion beam can also be used for machining at the nanoscale
down to feature sizes that are 10-20 times smaller than achievable using a standard
focused ion beam microscope with a gallium ion source. Nanomachining may involve
resists and material removal by sputtering, but it is also possible to locally deposit for
example Pt, W, or SiO2 from precursor gases using the helium ion beam. After a brief
overview of the technique, different applications for imaging and nanofabrication
using the sub-nanometer sized probe of the helium ion microscope will be presented.
Oxide-nanotube arrays for solar energy conversion
Prof. Dr. Patrik Schmuki
Department Werkstoffwissenschaften,
[email protected]
Self-organized, vertically-aligned titanium oxide nanotube layers can be grown on any
Ti metal surface by an adequate electrochemical anodization process. Titanium dioxide
is a wide band-gap semiconductor that is extremely resistant and has interesting
photoelectrochemical and surface catalytic properties. Therefore it has a high potential
for technological exploitation, such as in dye-sensitized solar cells and photocatalytic
applications (such as photolytic pollution degradation, or photoelectrochemical water
splitting for hydrogen generation).
Different doping, band-gap and defect engineering approaches have recently been
realized and strongly improved the performance of these layers. The talk will address
synthesis, modification and particularly applications of these nanotube structures in
energy conversion concepts.
Perspectives of artificial leafs for solar fuel generation: physical boundary conditions and material science challenges
Prof. Dr. Wolfram Jaegermann
Material Science, Technische Universität Darmstadt
[email protected]
For an effective conversion of solar energy to a chemical fuel, inorganic based “artificial leafs” have been suggested. It can be deduced from fundamental considerations
how the involved elementary processes must be coupled to each other to avoid severe
losses in the number and the chemical potential of the originally generated electronhole pairs. Efficient charge carrier generation and separation may be realized by thin
film semiconductor devices – preferentially in multi-junction cells – which may provide
high photocurrents and photovoltages. Subsequently, H2 and O2 evolution reactions
from H2O must be catalyzed with well-chosen electrocatalysts applying knowledge
based interface engineering on semiconductor contacts. Technologically feasible solutions seem to be possible, as we will show using thin film Si cells. Our recent investigations combine specifically developed multijunction cells with electrochemical investigations coupled to surface science experiments.
Highly efficient thin film solar cells – How nanostructuring can help to
improve the performance further
Dr. Stephan Bücheler
Laboratory for Thin Films and Photovoltaics, Empa, Dübendorf (CH)
[email protected]
Devices such as solar cells, electronic circuit elements, fuel cells or batteries are often
based on thin film stacks where controlled interface design is crucial to ensure optimal
functionality. Innovative interface and surface engineering based on the formation of
nanostructures can give rise to enhanced device performance. However, this typically
requires complex processing steps, especially when targeting features in the lower
nanometer scale.
Here we show a novel surface nanopatterning method to form homogeneously
distributed nanostructures (<30 nm) on the facetted, rough surface of polycrystalline
chalcogenide thin films by selective dissolution of self-assembled and well-defined
alkali condensates. As a first application, we show that in the case of Cu(In,Ga)Se2 thin
film solar cells, recombination at the heterojunction interface can be substantially reduced by the presence of nano-holes. These nanostructures are formed by a bottom-up
self-assembly of alkali-salt crystals. The simple concept is transferable to other material
systems and opens up new opportunities of enhancing electrical and/or optical properties of multi-layer devices.
Neue Themen und Strukturen in der Nano-BioMedizin
Dr. Klaus Michael Weltring
Gesellschaft für Bioanalytik Münster e.V.
[email protected]
The application of nanotechnologies to medical applications, abbreviated as NanoBioMedicine, provides technical solutions for the paradigm shift in medicine towards
personalized, preventive, regenerative and tele medicine. Although there are several
products on the market the translation rate of the huge investment of more than 500
Mio Euros for R&D projects in FP7 is insufficient. The presentation will describe topics,
structures and concepts aiming at improving the development and translation of NanoBioMedicine in Europe.
Integration von Nanostrukturen im Materialsystem:
Entscheidender Wert der Charakterisierung
Prof. Dr. Martin Strohrmann
BASF SE, Ludwigshafen
[email protected]
Bei BASF nutzen wir Nanotechnologie zur gezielten Entwicklung von Materialien für
nachhaltige Lösungen mit herausragender Leistung. Nanomaterialien mit neuen Funktionalitäten führen zu neuen oder verbesserten Produkten in der Elektronik, im Bauwesen, in Verbraucherprodukten, im Automobil und in der Energiewirtschaft.
BASF ist eine der führenden Firmen in der chemischen Nanotechnologie, und fokussiert auf die mittleren Stufen der Wertschöpfungskette. Die Kompetenzen reichen vom
Design nanostrukturierter Materialien und Oberflächen, deren Modellierung, Synthese,
Charakterisierung und Formulierung bis zur Integration im Materialsystem unserer
Kundenindustrien.
Allen unseren Produkten, die mit Nanotechnologie erfolgreich sind, ist gemein, dass
die Funktionalität des Materialsystems optimiert wurde, nicht die Funktionalität
nanostrukturierter Einsatzstoffe. Methoden zur Charakterisierung müssen jeweils
weiterentwickelt und validiert werden, um die Leistung des Materialsystems über die
Wechselwirkung der Nanostrukturen zu optimieren. So werden Silber-Nanodrähte erst
durch ihre Formulierung mit Additiven einsetzbar, um aus flüssiger Phase eine transparente Elektrode zu bilden, die kostengünstiger und weniger energieintensiv ist als
das bisher verwendete ITO. Oft hingegen ist keiner der Einsatzstoffe nanostrukturiert,
und stattdessen entsteht die funktionelle Nanostruktur in einem reaktiven Prozess, der
das finale Produkt erzeugt. Beispiele hierfür sind die Ultrafiltrationsmembranen zur
Wasseraufbereitung, die kratzfesten anorganisch vernetzten Automobillacke, oder die
organischen Aerogele zur dünnwandigen Wärmedämmung.
Stabilisierung von photokatalytischen Nanopartikelstrukturen für
Hochtemperaturanwendungen
Prof. Dr. Alfred Weber
Institut für Mechanische Verfahrenstechnik, Technische Universität Clausthal
[email protected]
Die Weiterentwicklung einer ganzen Reihe von zukunftsorientierten Technologien
auf der Basis von halbleitenden TiO2-Nanopartikeln wie dem restlosen Schadstoffabbau aus Abwasser/Abluft, der Wasserstoffgewinnung durch solare Wasser/OrganikSpaltung und der Energiekonversion durch Farbstoffsolarzellen setzt ein klares,
richtungsweisendes Konzept zum Materialdesign voraus. Neben der Aufstellung von
grundlegenden Gesetzmäßigkeiten zwischen den Charakteristika von Nanopartikeln und ihrer Leistungsfähigkeit bestimmt auch die anwendbare Prozesstechnik das
Applikationsfenster der Nanopartikeln. In diesem Vortrag soll gezeigt werden, wie die
Thermostabilität von TiO2-Nanopartikeln durch die Passivierung der interpartikulären
Kontaktpunkte um mehrere hundert Grad Kelvin erhöht werden kann, was ihren
Einsatz z.B. für selbstreinigende Beschichtungen auch bei hohen Verarbeitungstemperaturen ermöglicht. Neben der Zielgenauigkeit der eingesetzten Stabilisierungstechnik,
die Gegenstand aktueller Forschungsvorhaben ist, wird auch die Übertragbarkeit auf
metallische Katalysatorpartikeln erörtert.
Posters
1.
NanoMat – Innovation through Collaboration
Frank Schramm, Christian Punckt, Jasmin Aghassi
NanoMat, Karlsruhe Institute of Technology
2.
Toxicity of unloaded and chemotherapeutics loaded
nanoparticles in a multicellular 3D tumor spheroid model
A. Hornung, M. Poettler, R.P. Friedrich, J. Zaloga, H. Unterweger, S. Lyer,
J. Nowak, S. Odenbach, C. Alexiou, C. Janko
University Hospital Erlangen; Technische Universität Dresden
3.
Flow cytometry for intracellular SPION quantification: Specificity
and sensitivity in comparison with spectroscopic methods
R.P. Friedrich, C. Janko, M. Poettler, P. Tripal, J. Zaloga, I. Cicha, S. Dürr,
J. Nowak, S. Odenbach, I. Slabu, M. Liebl, L. Trahms, M. Stapf, I. Hilger,
S. Lyer, C. Alexiou
University Hospital Erlangen; Technische Universität Dresden;
Physikalisch-Technische Bundesanstalt Berlin; University Hospital Jena
4.
Development of Near Infrared Transparent Perovskite Solar Cells
for Tandem Application with Cu(In,Ga)Se2
Fan Fu, Thomas Feurer, Timo Jäger, Enrico Avancini, Benjamin Bissig, Stephan Buecheler,
Ayodhya N. Tiwari
Empa, Dübendorf, Switzerland
5.
Atom probe microscopy – Characterization of materials at the
atomic scale
Urban Rohrmann, Konrad Güth
Fraunhofer-Institut für Silicatforschung, Hanau
6.
Multifunctional nanoparticles for medical imaging
M. Straßer, S. Dembski, K. Mandel, J. Schrauth, D. Haddad, B. Ahrens,
S. Schweizer, H. Walles
Fraunhofer-Institut für Silicatforschung, Würzburg
7.
Black TiO2 nanotubes for solar hydrogen generation
Ning Liu, Patrik Schmuki
Department of Materials Science WW-4, LKO, FAU Erlangen-Nürnberg
8.
TiO2 nanotubes in dye-sensitized solar cells
Ning Liu, Patrik Schmuki
Department of Materials Science WW-4, LKO, FAU Erlangen-Nürnberg
9.
Mesoporous silica particles for functional materials: surfactantmodulated control of morphology
Leana Travaglini, Eko. A. Prasetyanto, Luisa De Cola
Université de Strasbourg
10.
Morphology and Structure Characterization by Confocal Raman
Spectroscopy
Thomas Nacken, Haichen Xing, Stefan Romeis, Rubitha Srikantharajah and
Wolfgang Peukert
Institute of Particle Technology (LFG), FAU Erlangen-Nürnberg
11.
Nonlinear Optical Spectroscopy for In Situ Studies of Fluid and
Nanomaterial Interfaces
Rebecca Dinkel, Christian Meltzer, Wolfgang Peukert, Björn Braunschweig
Institute of Particle Technology (LFG), FAU Erlangen-Nürnberg
12.
Continuous Hydrogenation of Liquid Organic Hydrogen Carriers
(LOHC) in a trickle-bed reactor
Michael Müller, Andreas Bösmann, Peter Wasserscheid
Institute of Chemical Reaction Engineering, FAU Erlangen-Nürnberg, Germany
13.
LOHC dehydrogenation – Catalyst development and investigation
into macrokinetics
Alexander Seidel, Willi Peters, Andreas Bösmann, Peter Wasserscheid
Institute of Chemical Reaction Engineering, FAU Erlangen-Nürnberg
14.
German-Japanese Symposium on Nanostructures
Henning Zoz
Zoz Group
15.
High Kinetic Processing Simoloyer® for Nanostructure Processing
Henning Zoz
Zoz Group
16.
Nanostructure Applications: Zentallium® (Al-CNT composite),
H2-OnAir (Aircraft Hydrogen Propulsion), FuturBeton
(High Performance Cement/Concrete)
Henning Zoz
Zoz Group
17.
Power to Gas to Fuel, P2G2F® - the Zoz-ZEV-Fleet
Henning Zoz
Zoz Group
18.
Theranostic polymeric micelles loaded with paclitaxel for
image-guided anticancer therapy
Benjamin Theek, Yang Shi, Maike Baues, Josef Ehling, Fabian Kiessling,
Wim Hennink, Twan Lammers
University Clinic and Helmholtz Institute for Biomedical Engineering,
RWTH Aachen University; Department of Pharmaceutics, Utrecht University,
The Netherlands
19.
Ultrasound-induced and microbubble-mediated sonoporation
to improve liposome delivery to tumors
Benjamin Theek, Maike Baues, Stanley Fokong, Seena Koyadan Veettil, Julia Steitz,
Fabian Kiessling, Twan Lammers
Department of Experimental Molecular Imaging, & Institute for Laboratory
Animal Science, RWTH Aachen University; Department of Pharmaceutics,
Utrecht University, The Netherlands
20.
Multimodal imaging of metastasis targeting and antimetastatic
therapy using polymeric, liposomal and micellar nanomedicines
L.Y. Rizzo, R. Pola, C. Rijcken, G. Storm, F. Kiessling, T. Lammers
Department of Experimental Molecular Imaging, University Clinic RWTH
Aachen; Institute of Macromolecular Chemistry, Academy of Sciences, Prague,
Czech Republik; Cristal Therapeutics, Maastricht, The Netherlands, Department
of Pharmaceutics, Utrecht University, Utrecht, The Netherlands; Department of
Targeted Therapeutics, University of Twente, Enschede, The Netherlands
21.
Atom probe tomography of nanoparticles
Peter Felfer
Department Materials Science, FAU Erlangen-Nürnberg;
Austrialian Centre for Microscopy and Microanalysis, The University of Sydney, Australia
22.
Raman spectroscopy in medicine: a high potential diagnostic
technique to reveal detailed structural changes in bones
and kidney tissues
G. Sarau, B. Hoffmann, S. Christiansen, C. Daniel, M. Büttner-Herold,
K. Amann, P. Milovanovic, E. Zimmermann, T. Yorgan, M. Amling, B. Busse
Helmholtz Centre Berlin for Materials and Energy; Max Planck Institute for the Science of
Light; Universitätsklinikum Erlangen, University Medical Center Hamburg-Eppendorf;
University of Belgrade, Serbia; Lawrence Berkeley National Laboratory / University of
California-Berkeley, USA
// Organization
Netzwerk NanoMat
Karlsruher Institut für Technologie
Hermann-von-Helmholtz-Platz 1
76344 Eggenstein Leopoldshafen
Phone: +49 721 608-28902
E-mail: [email protected]
[email protected]
Exzellenzcluster Engineering of Advanced Materials (EAM)
http://eam.fau.de

Complete Program

Transcrição

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