COMUNICAÇÃO TÉCNICA Nº 173771 Production of polymeric

COMUNICAÇÃO TÉCNICA
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Nº 173771
Production of polymeric nanoparticles by nanoprecipitation using
microfluidic systems.
Bianca Oliveira Agio
H. Cobas-Gomez
Andre Rocha Monteiro Dias
Natália Neto Pereira Cerize
Adriano Marim de Oliveira
A.C. Seabra
Mario Ricardo Gongora-Rubio
Resumo aspresentado no 14, BRAZILIAN MRS MEETING,
Rio de Janeiro, 2015.
A série “Comunicação Técnica” compreende trabalhos elaborados por técnicos do IPT, apresentados em
eventos, publicados em revistas especializadas ou quando seu conteúdo apresentar relevância pública.
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Instituto de Pesquisas Tecnológicas do Estado de São Paulo
S/A - IPT
Av. Prof. Almeida Prado, 532 | Cidade Universitária ou
Caixa Postal 0141 | CEP 01064-970
São Paulo | SP | Brasil | CEP 05508-901
Tel 11 3767 4374/4000 | Fax 11 3767-4099
www.ipt.br
Production of polymeric nanoparticles by
nanoprecipitation using microfluidic systems
B. O. Agio1, H. Cobas-Gomez2, A. R. M. Dias1, N. N. P. Cerize1, A. M. de Oliveira1, A. C.
Seabra2 & M. R. Gongora-Rubio1.
1
Instituto de Pesquisas Tecnológicas do Estado de São Paulo (IPT), Núcleo de
Bionanomanufatura, Av. Prof. Almeida Prado, 532, 05508-901, São Paulo, Brazil.
2
Escola Politécnica da Universidade de São Paulo.
Abstract:
The nanoprecipitation technique using microfluidics is able to generate nanoparticles that can
be employed to obtain products in different areas, such as pharmaceutical and chemistry. This
study aims to compare the batch production technique and the continuous flow manufacturing
technique using microfluidic devices, which present advantages like: a lower polydispersity
index and less consumption of energy and raw material. For the experiment was developed a
microfluidic device made in 3D using LTCC (Low Temperature Cofired Ceramics)
technology. The device is composed of three main parts: dissolved material input, anti-solvent
input and nanoprecipitation channel. The tests to obtain the polymeric nanoparticles were
carried out through the nanoprecipitation process in water of a block copolymer consisting of
Pluronic F127 and Polycaprolactone pre-solubilized in acetone were solubilized in acetone
with hydrocortisone acetate added. Nanoparticles obtained in this study were characterized by
the average size of particle employing the technique of dynamic light scattering. The results
obtained in this work presented the formation of nanoparticles of sizes ranging from 118.9
and 459.1 nm with a polydispersity index (PDI) between 0.102 and 0.235.
Acknowledgments:
FINEP-Agência Brasileira de Inovação.
References:
S. Strainmesse, A. M.Orecchioni, E. Nakache, F. Puisieux, and H. Fessi, “Formation and
stabilization of a biodegradable polymericcolloidal suspension of nanoparticles,” Colloid &
Polymer Science, vol. 273, pp. 505-511, 1995.
J.N. Schianti, N. P. N. Cerize, A. M. Oliveira, S. Derenzo, and M. R. Góngora-Rubio, “3D
LTCC microfluidic device as a tool for studying nanoprecipitacion”, IBERSENSOR 2012.
H.Cobas-Gomez, M. R. Gongora-Rubio, B. O. Agio, V. T. Kimura, A. M. de Oliveira, L. W.
S. L. Ramos, A. C. Seabra. “3D focalization microfluidic device built with LTCC technology
for nanoparticle generation using Nanoprecipitation route,” CICMT 2015, Dresden, Germany.