Grundlagen der Bioprozesstechnik 1 Module name Bioprocess

Modulbeschreibung Angewandte Naturwissenschaften – Grundlagen der Bioprozesstechnik
Module name
In semester
Module code
ECTS-Points
Working hours
Duty mark
Teaching language
Offered
Usability for other
courses of studies
Conditions for
participation
Target of the module
Content
1
Bioprocess engineering principles
rd
3 semester BTB
304
6
Sum 180
Contact time 90
Self-study time 60
Exam preparation 30
P
German
in each semester
“Biochemical Engineering 1” and “Enzyme Kinetics” may be used for the course of
studies “Mechatronics/Precision Engineering and Microsystems”
Modules Mathematics 1+2, Physics, Biology, Basic process engineering or equivalent
knowledge
Overall target (Knowledge, Skills, Competences):
- Well-grounded knowledge of life sciences and engineering sciences
- Understanding of the interdependencies within the field of biotechnology and
related disciplines.
- Ability to recognise, analyse, formulate and – with the help of specialist literature –
to solve complex and challenging problems in biotechnology and in related
disciplines
- Ability to organise and implement further learning processes independently
The following modules or subjects contribute to the overall target:
- Cell biology and microbiology
- Biochemistry 2
- Molecular biology
- Medical biotechnology
- Bioanalytics
- Basic process engineering
- Bioprocess engineering principles
- Biochemical engineering
- Cell culture technology
- Instrumental analytics
- Downstream processing
- All electives
Target of this module:
Ability to apply the theoretical fundamentals of biochemical engineering, enzyme
kinetics and measuring and control technology; ability to design and calculate
bioprocesses
Biochemical Engineering 1:
- mathematical models describing the growth and product formation of
microorganisms and cell cultures
- process control of bioreactors (batch, fedbatch, chemostat, perfusion)
- mass balance equations
- design of bioreactors
Enzyme Kinetics:
- introduction to enzymes
- Michaelis-Menten kinetics
- inhibition kinetics
- enzyme kinetics with multiple substrates
- temperature and pH influence on enzyme kinetics
- mathematical computation and simulation of kinetics
- evaluation of experimental data to determine kinetic parameters
Process measurement and control:
- introduction to control theory
- fundamentals of measuring technology
- process flow diagrams
- instrumentation of bioreactors
- Controllers (PID-control, two-position control, fuzzy-control, cascade control,…)
- specification of control loops (performance, stability)
- control design, determination of controller parameters
- control of bioreactors (temperature, pH, pO2)
- practical design of flow and level control
Modulbeschreibung Angewandte Naturwissenschaften – Grundlagen der Bioprozesstechnik
Literature
Responsible
2
H. Chmiel: Bioprozesstechnik. 3. Auflage. Spektrum Akademischer Verlag, München
2011
H. Bisswanger: Enzymkinetik - Theorie und Methoden, 3. Aufl., Verlag: Wiley-VCH,
2000
W. Storhas.: Bioverfahrensentwicklung, Verlag: Wiley-VCH, 2003
V. Hass, R. Pörtner: Praxis der Bioprozesstechnik.
2. Auflage. Spektrum Akademischer Verlag, München 2011
J. Reichwein, G. Hochheimer, D. Simic, Messen, Regeln und Steuern, Wiley-VCH,
Weinheim, 2007
H. Mann, H. Schiffelgen, R. Froriep, Einführung in die Regelungstechnik, Hanser,
München, 2005
lecture notes
R. Biener
Sections and efficiency statements
Form of instruction
SWS
Lecture „Biochemical
Engineering 1“ with
post processing
including exercises
and preparation of
the exam
2
Lecture „Enzyme
Kinetics“ with post
processing including
exercises and
preparation of the
exam
2
Lecture „Process
measurement and
control“ with post
processing including
exercises,
preparation of the
exam and lab work
2
Sum
6
Targets
- ability to model the growth and
production behaviour of
microorganisms and cell cultures
- ability to apply process control
strategies to bioprocesses
- ability to balance and design
bioprocesses
- understanding of the interaction of the
individual components in a bioprocess
- knowledge of the fundamentals of
enzymes
- knowledge of enzyme kinetics and its
applications
- ability to evaluate and analyse enzyme
kinetic data (e.g. Matlab)
- ability to determine kinetic parameters
from experimental data
- ability to apply the fundamentals of
control technology
- ability for the instrumentation of
bioreactors
- knowledge of controller types
- knowledge of the specification of
control loops
- ability for the practical design of
controllers
Examination form
and duration
Working
hours
written exam part
45 min.
60
written exam part
45 min.
60
written exam
60 min., report
60
180