Apresentação do PowerPoint - Springer Static Content Server

Apresentação do PowerPoint - Springer Static Content Server

PEGylation of SPIONs by polycondensation
reactions: A new strategy to improve colloidal
stability in biological media
Journal of Nanoparticle Research
Wesley Renato Viali1, Eloiza da Silva Nunes1, Caio Carvalho dos Santos1, Sebastião
William da Silva2 , Fermin Herrera Aragón2; José Antonio Huamaní Coaquira2, Paulo
César Morais2,3, Miguel Jafelicci Júnior1*
1
Laboratório de Materiais Magnéticos e Coloides, Departamento de Físico-química,
Instituto de Química, Universidade Estadual Paulista, Araraquara, SP, 14801-970, Brazil
2
Instituto de Física, Núcleo de Física Aplicada, Universidade de Brasília, Brasília, DF,
70910-900, Brazil
3
Department of Control Science and Engineering, Huazhong University of Science and
Technology, Wuhan 430074, China.
*Corresponding Author: [email protected] ; Fone: +55 16 3301-9651
Raman Intensity (u.a)
200
670
713
315
385
400
506
600
-1
Wavenumber (cm )
800
Fig. S1 Raman Spectra of Mag-1000 using a 632.8 nm laser
Fig. S2 HR-TEM micrograph of Mag-PEG1000 sample
160
Number of Particles
a
b
120
80
40
0
20 nm
2
4
6
8
10
Particle diameter (nm)
12
100
Number of Particles
c
20 nm
80
d
60
40
20
0
2
4
6
8
Particle diameter (nm)
Fig. S3 a TEM micrograph of Mag-cit sample; b particle size histogram of Mag-cit sample; c
TEM micrograph of Mag-PEG200 sample; d particle size histogram Mag-PEG200 sample
10
Fig. S4 a
13C
NMR spectra and; b DRIFTS of PEG-citrate co-polymer synthesized in the
absence of SPIONs. PEG Mw 1000
Fig. S5 Dependence of the stability factor, W, on the NaCl concentration at pH = 7 for
Mag-citrate (–●–) and Mag-PEG200 (–■–)
Fig S6 Hydrodynamic diameter as a function of time at MgCl2 concentrations ranging
from 0.01 to 1.0 mol L-1 (pH = 7.0): a Mag-PEG400; b Mag-PEG600; c Mag-PEG1000;
d Mag-PEG3350
Fig S7 Data relating to Mag-PEG 1000 synthesized in the absence of citric acid
(control). a Hydrodynamic diameter versus pH at 0.002 mol L-1 NaCl; b
Hydrodynamic diameter versus time at pH = 7.0
a
b
Fig S8 Surface-modified SPIONs, Mag-cit and Mag-PEG (polymer Mw 200, 400,
600, 1000 and 3350), dispersed in DMEM containing 10% of foetal bovine serum.
a right after preparation; b after 20 days