Miravalle, Augusto Alberto - University of Colorado Denver

CURRICULUM VITAE
Miravalle, Augusto Alberto
Assistant Professor of Neurology
Department of Neurology
University of Colorado, Denver, CO
Academic Office 1, Mail Stop B185
12631 East 17th Avenue/Room 5221
Aurora, CO 80045
Office: (303) 724-2187
Fax: (303) 724-2203
MEDICAL EDUCATION:
Harvard University. Brigham and Women’s Hospital. Boston, MA USA
• Laboratory for Neuroimaging Research
January 2009 to June 2009
Neuroimaging Research Fellow
Harvard University. Beth Israel Deaconess Medical Center. Boston, MA USA
• Multiple Sclerosis Clinical Fellowship
July 2008 to June 2009
Loyola University Medical Center. Hines VA Hospital. Chicago, IL USA
• Chief Resident in Neurology
July 2007 to June 2008
• Neurology Residency
July 2005 to June 2008
Resurrection-Westlake Hospital. Melrose Park, IL USA
• Internal Medicine Residency - Preliminary year.
July 2004 to June 2005
Universidad Nacional de La Plata, La Plata, Buenos Aires Argentina
• Medical School – Degree: Doctor in Medicine
March 1995 to Dec. 2001
ACADEMIC APPOINTMENTS:
University of Colorado, Department of Neurology
• Associate Residency Program Director
• Assistant Professor of Neurology
HOSPITAL POSITIONS:
University of Colorado Hospital, Denver, CO
• Staff Neurologist
January 2011 to present
August 2009 to present
August 2009 to present
The Children’s Hospital, Denver, CO
• Staff Neurologist
January 2011 to present
Parkview Medical Center, Pueblo, CO
• Staff Neurologist
August 2009 to present
St. Mary Corwin Medical Center, Pueblo, CO
• Staff Neurologist
October 2009 to present
COMMITTEES AND SERVICE RESPONSIBILITIES
University of Colorado, Department of Neurology
• Residency Education Curriculum Committee
• Hospitalist Program
• Residency selection committee
• Neurology Residency Faculty Mentor
January 2011 to present
December 2010 to present
November 2010 to present
August 2009 to present
University of Colorado, School of Medicine
• Admissions committee
September 2010 to present
MEDICAL HONORS/AWARDS:
Loyola University Medical Center, Chicago, IL USA
• “Housestaff Magis Spirit Award”. In recognition of exceptional service to Loyola
University Health System. June 2008
• “Frank A. Rubino Clinical Neurology Award”. In recognition for excellence in
patient care and education in the art and sciences of Neurology. June 2007
• Chief Resident. Department of Neurology, Residency Program. July 2007
Universidad Nacional de La Plata, La Plata, Buenos Aires Argentina
• Highest Academic Distinction. Second place in 2001 class. Cumulative final
grade in Medical School: 9.38/10.0. March 2002.
• Award for “Best Teaching Assistant”. In recognition of the significant
contribution to education and patient care. Department of Internal Medicine.
December 1999.
EXAMINATIONS:
USMLE Step 3
ECFMG CSA
USMLE Step 2
TOEFL
USMLE Step 1
Passed - December 2006.
Passed - February 2003.
Passed - November 2002.
Passed - November 2002.
Passed - August 2002.
MEDICAL LICENSURE:
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State of Colorado. Department of Regulatory Agencies. Licensed Active
Physician. November 2008 to present.
State of Massachusetts. Department of Financial and Professional Regulation.
Licensed Physician and Surgeon. July 2008 to June 2009.
State of Illinois. Department of Financial and Professional Regulation. Licensed
Physician and Surgeon. July 2007.
CERTIFICATIONS:
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Certification in Neurology, and Neurology with Special Qualification in Child
Neurology. December 2008. American Board of Psychiatry and Neurology
Certification by ECFMG - March 2003.
CURRENT MEMBERSHIPS:
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American Academy of Neurology
Colorado Society of Clinical Neurologists
June 2005 to present
January 2011 to present
LANGUAGE FLUENCY:
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Spanish
English
VOLUNTEER EXPERIENCE:
Metro Community Provider Network (MCPN), Aurora, CO
• Multiple Sclerosis Clinic. Provide subspecialty care for underserved populations
and uninsured patients. January 2010 to present
Loyola University Medical Center Stritch School of Medicine:
• System Pharmacy and Therapeutics Committee. Active member.
July 2007 to June 2008
• Neuroscience lecture series for medical school students. Neuroanatomy.
July 2006 to July 2008.
• Mentor program for first and second year medical school students.
July 2006 to July 2008
• Neuroscience lecture series for internal medicine residents. Clinical Neurology.
July 2006 to June 2007
Universidad Nacional de La Plata, La Plata, Buenos Aires Argentina
• Graduate Teaching Assistant. Department of Internal Medicine
March 2002 to May 2004.
• Student Teaching Assistant. Department of Internal Medicine
March 1999 to December 2001.
• Internal Medicine on call duties. San Martin Hospital, La Plata, Buenos Aires
April 1997 to May 2004.
• Student Teaching Assistant. Department of Biological Sciences
March 1997 to December 1999.
PRESENTATIONS:
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Biomarkers in MS. Rocky Mountain MS Center Research Conference. Fort
Collins, Colorado, April 2011
Updates on AAN meeting. MS therapies. Department of Neurology, University of
Colorado, Denver. April 2011
Brainstem syndromes. Localization in Clinical Neurology review. Department of
Neurology, University of Colorado, Denver. January 2011
Biomarkers in Multiple Sclerosis. Department of Neurology, University of
Colorado, Denver. December 2010
Multiple Sclerosis as a model for neurophysiological disorder. Molecules to
Medicine. Department of Physiology, University of Colorado, Denver. November
2010
Clinical case conference. Neuroimmunology. Department of Neurology,
University of Colorado, Denver. October 2010
Spinal Cord Disorders. From neuroanatomy to clinical cases. Department of
Neurology, University of Colorado, Denver. August 2010
Emerging MRI techniques in MS. Beyond white matter lesions. Latest Advances
in the treatment of MS. Inverness Hotel, Englewood, CO. November 2009.
Immune Reconstitution Inflammatory Syndrome after discontinuation of
Natalizumab therapy in MS patients. Presented at 14th Annual Meeting
ACTRIMS, Atlanta, May 2009.
Low dose Rituximab protocol for patients with RRMS. Presented at AAN
meeting, Seattle, April 2009.
Role of B cells in MS. Department of Neurology, University of Colorado, Denver.
October 2008.
ADEM complicating Yellow Fever vaccination. Loyola University Medical
Center Stritch School of Medicine. Department of Neurology, Maywood, Il. May
2008
Clinical Neurology. Board Review. Loyola University Medical Center Stritch
School of Medicine. Internal Medicine Department Maywood, Il. March 2008
Viral Hemorrhagic Fevers and Other CNS Infections in the International Traveler.
Grand rounds. Loyola University Medical Center Stritch School of Medicine.
Department of Neurology, Maywood, Il. November 2007
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Infectious CNS vasculitis. Grand rounds. Loyola University Medical Center
Stritch School of Medicine. Department of Neurology, Maywood, Il. November
2007
Radiation Induced Frontal Lobe Atypical Meningioma. Clinico-Pathological
Conference. Loyola University Medical Center Stritch School of Medicine.
Department of Neurology, Maywood, Il. July 2007
Infectious Disorders of the CNS. Selective CNS complications. Grand rounds.
Loyola University Medical Center Stritch School of Medicine. Department of
Neurology, Maywood, Il. June 2007
ADEM, AHLE, and Postinfectious Encephalomyelitis. Loyola University Medical
Center Stritch School of Medicine. Department of Neurology, Maywood, Il.
January 2007
Nemaline Rod Myopathy. Case report and review of the literature. ClinicoPathological Conference. Loyola University Medical Center Stritch School of
Medicine. Department of Neurology, Maywood, Il. October 2006
Leukodystrophies. Loyola University Medical Center Stritch School of Medicine.
Department of Neurology, Maywood, Il. August 2006
Benedict syndrome. Case report and review of the literature. Grand rounds.
Loyola University Medical Center Stritch School of Medicine. Department of
Neurology, Maywood, Il. July 2006
Mitochondrial Disorders. Adult presentation of Leigh’s Disease. Case report and
review of the literature. Grand rounds. Loyola University Medical Center Stritch
School of Medicine. Department of Neurology, Maywood, Il. August 2005
RESEARCH EXPERIENCE (past):
Harvard University. Brigham and Women’s Hospital. Boston, MA USA
• Miravalle A, Neema M, Bakshi R. Clinical MRI-MS Imaging Center. T2 relaxometry,
R2 and R2* analysis in RRMS patients. January 2009 to June 2009
Indiana University Medical Center, Department of Neurology, Indianapolis, IN.
• Miravalle A, Roos KL. Encephalitis complicating Smallpox vaccination. November
2002. Description: Review of the literature and analysis of potential consequences of
Smallpox infection as a biological weapon.
Universidad Nacional de La Plata, La Plata, Buenos Aires Argentina
• Miravalle A, Belloni R, Suarez I, Giacommantone O. Relationship between BMI and
hypertension in the hospital population. Description: Prospective study in outpatient
population admitted to Internal Medicine Department during the 1998-2000 year period.
Presented at the XII Internal Medicine Meeting - La Plata, Bs. As. Argentina. May 2000.
CLINICAL RESEARCH (current):
A Multicenter, Double-blind, Randomized, Parallel-group, Monotherapy, Active-control
Study to Determine the Efficacy and Safety of Daclizumab High Yield Process (DAC
HYP) versus Avonex® (interferon beta 1a) in Patients with RRMS. DECIDE. Biogen
Idec. Principal investigator
A Phase III, Double-Blinded, Active Comparator, Randomized, Placebo-Controlled
Study to Evaluate Glatiramer Acetate Daily Therapy to Glatiramer Acetate Three Times
Weekly Therapy in Patients with Relapsing Multiple Sclerosis. GALA. Teva
Pharmaceuticals. Principal Investigator
ELND002-MS103. A Phase 1b, Dose-Escalating, Randomized, Placebo-Controlled,
Double-Blined Study to Evaluate the Safety and Efficacy of Subcutaneous ELND002 in
Patient with Relapsing Forms of MS. Elan Pharmaceuticals. Co-Investigator
A Single-arm, Two-period, Cross-over, Phase IIb Trial of an Alternative dosing Strategy
for Natalizumab. NADS. Biogen Idec. Co-Investigator
JCV Antibody Program in Patients with Relapsing Multiple Sclerosis Receiving or
Considering Treatment with Tysabri. Biogen Idec STRATIFY-1. Co-Investigator
Myxovirus-Resistant Protein A as a Measure of Clinical Efficacy of Interferon-Beta
Treatment in Patients with Multiple Sclerosis. (Biosite MARBLE) Co-Investigator
Multiple Subcutaneous Doses of LY2127399, an Anti-BAFF Human Antibody, in
Subjects with Relapsing Remitting Multiple Sclerosis. Eli Lilly and Co. BCDJ CoInvestigator
A Longitudinal, Case-Control Study to Collect Medical and Epidemiological Data and
Blood Samples for Research Into the Causes of Multiple Sclerosis and Selected
Demyelinating Diseases. Accelerated Cure Project Co-Investigator
Tysabri® Global Observational Program in Safety (TYGRIS), Biogen Idec CoInvestigator
A Phase III, Randomized, Double-blind, Placebo-controlled, Multicenter Clinical Trail of
Oral Cladribine in Subjects With a First Clinical Event at High Risk of Converting to
MS. Serono Oracle Co-Investigator
A Double-blind, Randomized, Multicenter, Placebo-controlled, Parallel-group Study
Comparing the Efficacy and Safety of 0.5 mg FTY720 Administered Orally Once Daily
Versus Placebo in Patients with Primary Progressive Multiple Sclerosis. Novartis
CFTY720D2306 Co-Investigator
A Multinational, Multicenter, Randomized, Parallel-Group study performed in subjects
with Relapsing-Remitting Multiple Sclerosis (RRMS) to assess the efficacy, safety and
tolerability of laquinimod over placebo in double-blind design and of a reference arm of
Interferon B-1a (Avonex®) in a rater-blinded design, Teva Neuroscience. (Bravo) CoInvestigator
Duloxetine in Patients with Central Neuropathic Pain Due to Multiple Sclerosis, Eli Lilly.
F1J-US-HMFR Co-Investigator
A Multi-Center, Double-Blind, Randomized Study Comparing the Combined Use of
Interferon Beta-1a and Glatiramer Acetate to Either Agent Alone in Patients with
Relapsing Remitting Multiple Sclerosis (CombiRx-Phase III), NIH/NINDS, CoInvestigator
PUBLICATIONS:
Miravalle A, Hendin B, Vollmer T and Kala M. Glatiramer Acetate in the Reduction of
Relapse Frequency in Multiple Sclerosis. Clinical Medicine Insights: Therapeutics
2011:3 151–158
Kala M, Miravalle A, Vollmer T. Recent insights into the mechanism of action of
Glatiramer acetate. J Neuroimmunol. 2011
Miravalle A, Jensen R, Kinkel R. Immune reconstitution inflammatory syndrome after
discontinuation of Natalizumab therapy in patients with MS. Arch Neurol. 2011
Feb;68(2):186-91
Miravalle A, Corboy J. Therapeutic options in MS. Five new things. Clinical Pratice
Journal. Neurology. 2010;75(Suppl 1):S1
Joseph R. Berger, Giancarlo Comi, Christian Confavreux, Fred Lublin, Augusto
Miravalle, et al. Considerations on Discontinuing Natalizumab for the Treatment of
Multiple Sclerosis. Annals of Neurology. 2010;68:3:409-411
Miravalle A, Schnitzler E, Bonwit A, Biller J. Neurological complications of
vaccinations. Neurological research. 2010;32:3:285-292.
Corboy J, Miravalle A. Emerging therapies for the treatment of MS. Journal of
Inflammation Research. 2010:3 53–59
Miravalle A, Bennett J. Recent advances in the treatment of multiple sclerosis. Journal of
Experimental Pharmacology 2010:2; 155-161
Miravalle A. Neurodegeneration: The clinical evidence. Adv Stud Pharm. 2010;7(3):5762
Nilsen S, Miravalle A, Langer Gould A, Cooper J, Kinkel R. B Cell Depletion and
Safety of Low Dose Rituximab in Patients with Relapsing Multiple Sclerosis. Submitted
for publication 2010.
Miravalle A. Lyme Disease. Neuroborreliosis. E-medicine. July 2009
Miravalle A. Ramsay Hunt Syndrome. E-medicine. August 2009
Miravalle A, Biller J, Silva E, Connelly M, O’Keefe P. ADEM complicating Yellow
Fever vaccination. Arquivos de Neuro-Psychiatria Vol 67, 2009.
Miravalle A, Roos KL. Encephalitis complicating Smallpox vaccination. Archives of
Neurology, July 2003. Volume 60;925:928.
Books/Chapters
Miravalle A, Schreiner T. Neurological complications of vaccinations. Neurological
aspects of systemic disease. Handbook of Clinical Neurology. Biller J, Ferro M. Elsevier.
2011
Miravalle A, Corbett J, Biller J. Infectious Causes of Stroke. Interface of Neurology and
Internal Medicine. Biller J. First edition. Lippincott Williams & Wilkins, Philadelphia
2007
Roos KL, Miravalle A. Postinfectious Encephalomyelitis. Infections of the Central
Nervous System. Scheld WM, Whitley RJ, Marra C. Third edition. Lippincott Williams
& Wilkins, Philadelphia 2004.
OTHER AWARDS/ACCOMPLISHMENTS:
DISCOGRAPHY:
Muzio Clementi - Works for piano - Quadromania - 4CDs. 1990
• Piano Sonata No. 5 in F major, op. 4
13. I. Allegro 3:08 · 14. II. Allegretto 3:42
Augusto Miravalle (piano)
• Piano Sonata No. 6 in B Flat major, op. 4
15. I. Allegro moderato 4:40 · 16. II. Rondo: Allegretto 2:28
Augusto Miravalle (piano)
MUSICAL EDUCATION:
Piano Master Classes:
• Emille Naoumoff. Madrid 1994
• Lazar Berman, Buenos Aires 1993
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Ralph Votapeck, Buenos Aires 1991
Rosalyn Tureck, New York 1990
Gilardo-Gilardi School of Music.
• Professor of Piano. Graduated 1993. Buenos Aires, Argentina.
PERFORMANCES AND PIANO COMPETITIONS:
National Piano Competition “Festivales Msuciales”.
• Second place. Silver medal. Buenos Aires, Argentina. September 1994.
Gina Bachauer International piano Competition. Salt Lake City Utah.
• Selected to participate in semifinals. 1990.
International Piano Competition.
• First place. Gold medal. Cordoba, Argentina. October 1987.
Orchestra performances:
• La Plata Chamber Orchestra, La Plata, Argentina
o Mozart’s piano concerto N3 in D major, K. 40. 1990
• San Martin Symphony Orchestra, Buenos Aires, Argentina
o Mozart’s piano concerto N3 in D major, K. 40. 1990
• Cordoba Symphony Orchestra, Cordoba, Argentina
o Mendelssohn’s piano concerto N1 G minor. 1988