Vaccyn: Extrato Padronizado em 20% de Antocianidinas
Transcrição
Vaccyn: Extrato Padronizado em 20% de Antocianidinas
1. Geriatria 2. Ortomolecular Agosto/Setembro de 2012 3. Nutrição/Nutrologia Vaccyn: Extrato Padronizado em 20% de Antocianidinas Bilberry + Blueberry + Cranberry Potente Ação Antioxidante Para Melhora da Visão, Memória e Aparência da Pele do Idoso 02 Vaccyn 02 Definição, Propriedades, Doses e Posologia, Indicações, Reações Adversas e Contraindicações 03 Vaccyn: Bilberry + Blueberry + Cranberry 05 Indicações Terapêuticas Baseadas em Evidências: Tratamentos Nutracêuticos Para a Saúde Cutânea e Ocular do Idoso 06 Indicações Terapêuticas Baseadas em Evidências: Suplementação Complementar Para a Melhora do Desempenho Cognitivo do Idoso 07 Indicações Terapêuticas Baseadas em Evidências: Nutracêuticos Auxiliares na Saúde dos Sistemas Cardiovascular e Metabólico em Idosos Lançamento: Novo Extrato Padronizado em 20% de Antocianidinas Promotor da Saúde Geral e da Pele do Idoso Propriedade Antioxidante Potente Para Melhora da Visão, Memória e Aparência da Pele Formulários Exclusivos de Nutracêuticos Auxiliares na Saúde dos Idosos Vaccyn Definição, Propriedades, Doses e Posologia, Indicações, Reações Adversas e Contraindicações Definição Vaccyn é um extrato padronizado em 20% antocianidinas, composto pelos extratos de três tipos de berries do gênero Vaccinium: Bilberry (Vaccinium myrtillus), Blueberry (Vaccinium corymbosium) e Cranberry (Vaccinium macrocarpon). Propriedades O gênero Vaccinium é um gênero que inclui diversos frutos comestíveis (exemplo: cranberry, bilberry e blueberry), cujo consumo tem sido associado a diversos efeitos benéficos para a saúde. Estudos mostram que uma série de compostos funcionais foram extraídos dos frutos e sementes das plantas do gênero Vaccinium, sendo que as antocianidinas, seu principal constituinte, possui propriedades antioxidante, antimicrobiana e anti-inflamatória. Johnson BJ, Lin B, Bongard JE. Genus vaccinium: medicine, cosmetics, and coatings. Recent Pat Biotechnol. 2010 Jun 1;4(2):112-24. Doses e Posologia A dose usual de Vaccyn é de 1 g ao dia. Estudos também mostram o uso da dose de antocianidinas de 20 a 40 mg, três vezes ao dia. [No authors listed] Monograph. Vaccinium myrtillus (bilberry). Altern Med Rev. 2001 Oct;6(5):500-4. Indicações As antocianidinas têm sido indicadas como suplemento: • Antioxidante geral para idosos (visão, pele e memória); • Melhora da vasodilatação endotélio-dependente em hipercolesterolêmicos; • Melhora do perfil lipídico; • Redução da inflamação; • Redução de infecções do trato urinário. indivíduos Zhu Y, Xia M, Yang Y, Liu F, Li Z, Hao Y, Mi M, Jin T, Ling W. Purified anthocyanin supplementation improves endothelial function via NO-cGMP activation in hypercholesterolemic individuals. Clin Chem. 2011 Nov;57(11):1524-33. doi: 10.1373/clinchem.2011.167361. Epub 2011 Sep 16. Pérez-López FR, Haya J, Chedraui P. Vaccinium macrocarpon: An interesting option for women with recurrent urinary tract infections and other health benefits. J Obstet Gynaecol Res. 2009 Aug;35(4):630-9. Reações Adversas e Contraindicações Extratos de bilberry e de outros berries do gênero Vaccinium possuem propriedades antiagregação plaquetária, e doses muito altas devem ser usadas com precaução em pacientes com distúrbios hemorrágicos ou que estiverem utilizando anticoagulantes ou antiplaquetários. [No authors listed] Monograph. Vaccinium myrtillus (bilberry). Altern Med Rev. 2001 Oct;6(5):500-4. Vaccyn: Bilberry + Blueberry + Cranberry Indicação Terapêutica Vaccyn ____________________ 500 mg Duas cápsulas ao dia, sendo uma pela manhã e uma à tarde. Saúde do Idoso Bilberry: Ação Antioxidante Para Saúde Cutânea e Ocular Vaccinium myrtillus (Bilberry) é um membro da família Ericaceae rico em flavonóides antocianosídeos (antocianinas). • Extratos de Bilberry contendo antocianosídeos têm demonstrado fortes propriedades: • Antioxidante, • Estabilizante de fibras de colágeno, • Promotoras da biossíntese de colágeno, • Diminui a permeabilidade e fragilidade capilar, • Inibe agregação plaquetária, Impede a liberação e síntese de compostos pró-inflamatórios como a histamina, prostaglandinas e leucotrienos. [No authors listed] Monograph. Vaccinium myrtillus (bilberry). Altern Med Rev. 2001 Oct;6(5):500-4. Blueberry: Polifenois Neuroprotetores Para Melhora da Cognição em Idosos Os principais componentes do blueberry (Vaccinium corymbosium) são as antocianinas e o ácido clorogênico, entre outros. Apresenta atividade de neuroproteção, impedindo as mudanças relacionadas à idade, bem como melhora a cognição em idosos. Yang H, Jiang Y. Research progress of bioactive constituents, absorption, metabolism, and neuroprotective effects from blueberry. Wei Sheng Yan Jiu. 2010 Jul;39(4):525-8. Blueberry possui alto conteúdo de polifenois, os quais podem ser úteis como agentes farmacológicos em várias doenças neurológicas, pois apresentam efeitos favoráveis relacionados à neuroproteção e redução do declínio cognitivo relacionado à idade. Giacalone M, Di Sacco F, Traupe I, Topini R, Forfori F, Giunta F. Antioxidant and neuroprotective properties of blueberry polyphenols: a critical review. Nutr Neurosci. 2011 May;14(3):119-25. Cranberry: Benefícios Para o Trato Urinário e Sistemas Cardiovascular e Metabólico Cranberry (Vaccinium macrocarpon) já se mostra como uma opção eficaz e muito utilizada no tratamento de infecção recorrente do trato urinário em mulheres bem como outras condições de saúde. Estudos sugerem que os componentes do cranberry podem ter benefícios potenciais, incluindo efeitos anti-infeccioso, anticancerígeno e antioxidante, que podem ser considerados positivos para diferentes condições relacionadas à idade. Além disso, os componentes do cranberry podem induzir mudanças positivas cardiovasculares e metabólicas, e podem melhorar a atividade neuropsicológica. Pérez-López FR, Haya J, Chedraui P. Vaccinium macrocarpon: An interesting option for women with recurrent urinary tract infections and other health benefits. J Obstet Gynaecol Res. 2009 Aug;35(4):630-9. Indicações Terapêuticas Baseadas em Evidências Tratamentos Nutracêuticos Para a Saúde Cutânea e Ocular do Idoso Isoflavonas da soja 100% _____ 100 mg Efeito Antirrugas em Mulheres PósTomar uma cápsula ao dia após o café Menopausadas da manhã. O tratamento com 100 mg de isoflavonas da soja resultou em um aumento de 9,46% na espessura da epiderme. A quantidade de colágeno na derme foi aumentada (86,2%), assim como o número de fibras elásticas (75,8%). O número de vasos sanguíneos da derme também aumentou significativamente. Accorsi-Neto A, Haidar M, Simões R, Simões M, Soares-Jr J, Baracat E. Effects of isoflavones on the skin of postmenopausal women: a pilot study. Clinics (Sao Paulo). 2009;64(6):505-10. Coenzima Q10 ______________ 50 mg Prevenção do Envelhecimento Vitamina E _________________ 50 mg Cutâneo Com Antioxidantes Selênio ___________________ 50 mcg Dose diária administrada junto com uma das principais refeições. O tratamento oral diário com 50 mg de CoQ10 + 50 mg de Vitamina E + 50 mcg de Selênio aumenta os níveis destes antioxidantes no estrato córneo e no plasma, retardando o processo de envelhecimento da pele. Passi S, De Pità O, Grandinetti M, Simotti C, Littarru GP. The combined use of oral and topical lipophilic antioxidants increases their levels both in sebum and stratum corneum. Biofactors. 2003;18(1-4):289-97. Luteína _______________________ 10 mg Melhora da Visão em Dose diária administrada junto a uma das Pacientes com Degeneração refeições. Macular Relacionada à Idade Um estudo mostrou que a luteína 10 mg/dia promove aumento da densidade do pigmento óptico macular em pacientes com degeneração macular relacionada à idade. Richer S, Devenport J, Lang JC. LAST II: Differential temporal responses of macular pigment optical density in patients with atrophic age-related macular degeneration to dietary supplementation with xanthophylls. Optometry. 2007 May;78(5):213-9. Indicações Terapêuticas Baseadas em Evidências Suplementação Complementar Para a Melhora do Desempenho Cognitivo do Idoso Picolinato de Cromo ___________ 1.000 mcg Melhora do Desempenho Dose diária administrada junto ou não de uma Cognitivo e da Função das refeições. Cerebral Resultados sugerem que a suplementação com picolinato de cromo, 1.000 mcg por dia durante 12 semanas, pode melhorar o desempenho cognitivo e a função cerebral em idosos com risco neurodegenerativo. Krikorian R, Eliassen JC, Boespflug EL, Nash TA, Shidler MD. Improved cognitive-cerebral function in older adults with chromium supplementation. Nutr Neurosci. 2010 Jun;13(3):116-22. Idebenona _______________________120 mg Tratamento da Demência e Dose diária administrada junto ou não de uma Perda Parcial de Memória das refeições. Sem Demência A idebenona na dose diária de 120 mg, por seis meses, demonstrou melhora a curto e longo prazo na memória e na atenção, com melhora na dicção, em testes dinâmicos, visuais, de imaginação e na escrita de pacientes com demência do tipo Alzheimer, demência mista e lapsos de memória não relacionados à demência. Voronkova KV, Meleshkov MN. Use of Noben (idebenone) in the treatment of dementia and memory impairments without dementia. Neurosci Behav Physiol. 2009 Jun;39(5):501-6. Creatina___________________________5 g Pó Para Suspensão Extemporânea com Whey Protein (aroma Shake de chocolate_______ 10 g Melhora do Desempenho Dissolver o conteúdo de um sachê em 200 ml de Cognitivo em Idosos água ou leite desnatado, agitar vigorosamente e ingerir em seguida. Administrar 4 vezes ao dia. Um estudo mostrou que a suplementação de creatina (20 g ao dia) auxilia na cognição em idosos, com efeitos significativos da suplementação de creatina em todos os testes de memória avaliados. McMorris T, Mielcarz G, Harris RC, Swain JP, Howard A. Creatine supplementation and cognitive performance in elderly individuals. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2007 Sep;14(5):517-28. Indicações Terapêuticas Baseadas em Evidências Nutracêuticos Auxiliares na Saúde dos Sistemas Cardiovascular e Metabólico em Idosos Pycnogenol (Pinnus Redução da Hipertensão e pinaster)_______________125 mg Outros Fatores de Risco Cardiovascular Dose diária administrada longe das refeições. Após 12 semanas de suplementação, Pycnogenol (125 mg/dia) resultou em uma melhora no controle do diabetes, baixou os fatores de risco cardiovascular, além de reduzir o uso de medicamento anti-hipertensivo quando comparado ao placebo. Zibadi S, Rohdewald PJ, Park D, Watson RR. Reduction of cardiovascular risk factors in subjects with type 2 diabetes by Pycnogenol supplementation. Nutr Res. 2008 May;28(5):315-20. Extrato de Pomegrante (Punica Redução dos Fatores de Risco granatum)___________1.000 mg Cardiovascular em Indivíduos Dose diária administrada após o café da Sobrepesados manhã. A dose de 1.000 mg ao dia do extrato de Pomegranate reduziu de forma significativa os níveis de TBARS, que foi correlacionado com a redução do risco cardiovascular em indivíduos com sobrepeso. Heber D, Seeram NP, Wyatt H, Henning SM, Zhang Y, Ogden LG, Dreher M, Hill JO. Safety and antioxidant activity of a pomegranate ellagitannin-enriched polyphenol dietary supplement in overweight individuals with increased waist size. J Agric Food Chem. 2007 Nov 28;55(24):10050-4. Epub 2007 Oct 30. Referências Bibliográficas Zibadi S, Rohdewald PJ, Park D, Watson RR. Reduction of cardiovascular risk factors in subjects with type 2 diabetes by Pycnogenol supplementation. Nutr Res. 2008 May;28(5):315-20. Heber D, Seeram NP, Wyatt H, Henning SM, Zhang Y, Ogden LG, Dreher M, Hill JO. Safety and antioxidant activity of a pomegranate ellagitannin-enriched polyphenol dietary supplement in overweight individuals with increased waist size. J Agric Food Chem. 2007 Nov 28;55(24):10050-4. Epub 2007 Oct 30. McMorris T, Mielcarz G, Harris RC, Swain JP, Howard A. Creatine supplementation and cognitive performance in elderly individuals. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2007 Sep;14(5):517-28. Voronkova KV, Meleshkov MN. Use of Noben (idebenone) in the treatment of dementia and memory impairments without dementia. Neurosci Behav Physiol. 2009 Jun;39(5):501-6. Krikorian R, Eliassen JC, Boespflug EL, Nash TA, Shidler MD. Improved cognitivecerebral function in older adults with chromium supplementation. Nutr Neurosci. 2010 Jun;13(3):116-22. Apoio Farmacotécnico Shake Base Pó para Suspensão Extemporânea com Whey Protein Fase Componentes Função A Whey Protein Veículo 18,0 g A Carboximetilcelulose (CMC) Espessante 0,30 g A Lecitina de Soja (pó) Emulsificante 0,15 g ® Quantidades para 1 sachê ** A Dióxido de Silício Coloidal (Aerosil 200 ) Antiumectante 0,25 g A Sucralose Edulcorante 0,10 g A Acessulfame K Edulcorante 0,10 g A Benzoato de Sódio Conservante 0,30 g A Aroma (pó) Flavorizante 1,0 g A Corante (pó) Opcional Corante 0,01 g B Nutriente funcional Ingrediente Ativo (x) mg Total ~ 20 g Modo de Preparo Etapa-1: Triturar, tamisar e misturar geometricamente os pós em ambiente com umidade relativa controlada FASE A; Etapa-2: Pesar a quantidade de pó para cada dose, acondicionar em sachê de tamanho adequado e selar; Etapa-3: Acondicionar os sachês em caixas cartonadas e rotular. Abstracts Clin Chem. 2011 Nov;57(11):1524-33. doi: 10.1373/clinchem.2011.167361. Epub 2011 Sep 16. Purified anthocyanin supplementation improves endothelial function via NO-cGMP activation in hypercholesterolemic individuals. Zhu Y, Xia M, Yang Y, Liu F, Li Z, Hao Y, Mi M, Jin T, Ling W. SourceGuangdong Provincial Key Laboratory of Food, Nutrition, and Health, School of Public Health,SunYat-Sen University (Northern Campus), Guangzhou, China. Abstract BACKGROUND: Anthocyanins have been shown to improve endothelial function in animal models. However, whether these compounds have similar beneficial effects in humans is largely unknown. METHODS: In a short-term crossover study, 12 hypercholesterolemic individuals were given oral anthocyanins (320 mg) isolated from berries or placebo. Brachial artery flow-mediated dilation (FMD) was assessed before and after the intervention. In a long-term intervention trial (12 weeks), 150 hypercholesterolemic individuals were given anthocyanins (320 mg/day, n = 75) or placebo (n = 75), after which we measured FMD, plasma cGMP, and other serum biomarkers. Another short-term intervention was conducted in the presence of NO-cGMP inhibitors in 6 people and in a rat aortic ring model (n = 8). RESULTS: Significant increases of FMD from 8.3% (0.6%) at baseline to 11.0% (0.8%) at 1 h and 10.1% (0.9%) at 2 h were observed after short-term anthocyanin consumption, concomitantly with increases of plasma anthocyanin concentrations (P < 0.05). In the study participants who received long-term anthocyanin intervention, compared with the control group, we observed significant increases in the FMD (28.4% vs 2.2%), cGMP (12.6% vs -1.2%), and HDL-cholesterol concentrations, but decreases in the serum soluble vascular adhesion molecule-1 and LDL cholesterol concentrations (P < 0.05). The changes in the cGMP and HDL cholesterol concentrations positively correlated with FMD in the anthocyanin group (P < 0.05). In the presence of NO-cGMP inhibitors, the effects of anthocyanin on endothelial function were abolished in human participants and in a rat aortic ring model. CONCLUSIONS: Anthocyanin supplementation improves endotheliumdependent vasodilation in hypercholesterolemic individuals. This effect involves activation of the NO-cGMP signaling pathway, improvements in the serum lipid profile, and decreased inflammation. PMID:21926181[PubMed - indexed for MEDLINE] Recent Pat Biotechnol. 2010 Jun;4(2):112-24. Genus vaccinium: medicine, cosmetics, and coatings. Johnson BJ, Lin B, Bongard JE. SourceCenter for Bio/Molecular Science and Engineering, Code 6900, Naval Research Laboratory, Washington, DC 20375, USA. [email protected] Abstract Vaccinium is a genus of shrubs several of which, including cranberry, lingonberry, and blueberry, produce edible fruit. Consumption of the fruit of these plants and juices pressed from it has long been known to have healthful effects. A number of functional compounds have been extracted from the fruits and seeds of these plants. Anthocyanidins and related compounds have been reported to possess antimicrobial, antioxidant, and anti-inflammatory properties. Extracts of the fruits have been applied to the inhibition of non-enzymatic glycosylation in anti-aging preparations. The oil of the cranberry seed is high in antioxidants and is a source of omega-3, -6, and -9 fatty acids making it an attractive cosmetics component. The inhibition of tumor growth, angiogenesis, and metastasis by extracts of these fruits has been described. Extracts of the plants have also been applied to the development of antimicrobial paints and coatings. Here, we provide an overview of the wide range of applications described for various compounds from and preparations of these plants and survey the recent patents related to those applications. PMID:20156133[PubMed - indexed for MEDLINE] Nutr Neurosci. 2011 May;14(3):119-25. Antioxidant and neuroprotective properties of blueberry polyphenols: a critical review. Giacalone M, Di Sacco F, Traupe I, Topini R, Forfori F, Giunta F. SourceIntensive Care Unit, Department of Surgery, University of Pisa, Pisa, Italy. Abstract OBJECTIVE: The aim of this work was to highlight the effects and the possible mechanisms of the action of blueberry polyphenols on the central nervous system (CNS). METHODS: An analysis was carried out, in a temporal order, of the most important literature about this topic and the results have been correlated with the beneficial and protective effects, mainly concerning the CNS. DISCUSSION: Over the last 10 years an increasing scientific interest has developed about polyphenols, which are very abundant in blueberries, as they have been seen to produce favourable effects related to neuroprotection and linked to a possible decrease of age-related cognitive and motor decline, as shown by the improvement of such functions in animal models with a supplemented diet. Such effects could not only be explained through a purely antioxidant action but also through more complex mechanisms related to inflammation, genic expression, and regulation of cell survival. CONCLUSIONS: Despite the wealth of data from animal studies, there is a relative lack of data concerning human beings, even if some positive results are beginning to emerge. Therefore, blueberry polyphenols could become useful pharmacological agents for various conditions including neurological diseases, but further studies are still necessary to attain this objective. PMID:21756533[PubMed - indexed for MEDLINE] Wei Sheng Yan Jiu. 2010 Jul;39(4):525-8. [Research progress of bioactive constituents, absorption, metabolism, and neuroprotective effects from blueberry]. [Article in Chinese] Yang H, Jiang Y. SourceDepartment of Nutrition and Food Science, Institute of Hygiene and Environmental Medicine, Tianjin 300050, China. [email protected] Abstract The main components of blueberry were anthocyanins, chlorogenic acid, citric acid, arbutin, myricetin and its glycoside and so on. It has the activities of neuroprotection, preventing the age-related changes of brain, cardiotonic activity, etc. Recently, the effects of blueberry extracts on the improve function of cognition has been attracted wide attention. This review summarizes the active components, absorption and metabolism of blueberry, especially focuses on neuroprotection and the mechanisms involved. PMID:20726253[PubMed - in process] J Obstet Gynaecol Res. 2009 Aug;35(4):630-9. Vaccinium macrocarpon: an interesting option for women with recurrent urinary tract infections and other health benefits. Pérez-López FR, Haya J, Chedraui P. SourceDepartment of Obstetrics and Gynecology, University of Zaragoza Faculty of Medicine, Clínico Universitario de Zaragoza Hospital, Zaragoza, Spain. [email protected] Abstract AIM: To review the scientific publications concerning the clinical use and mechanism of action of the North American cranberry (Vaccinium macrocarpon) for women with recurrent urinary tract infections (UTI) and other health conditions. METHODS: This is a retrospective study of published information concerning Vaccinium macrocarpon retrieved from a PubMed and individual searches. RESULTS: Urinary tract infections are very common in women, cause discomfort, and may aggravate other genitourinary conditions. The available scientific information supports a clinical benefit of Vaccinium macrocarpon in the prevention of recurrent UTI in women. There is a non-significant reduction of UTI associated with Vaccinium macrocarpon treatment during pregnancy. A group of proanthocyanidins (PAC) with A-type linkages have been isolated from Vaccinium macrocarpon which inhibit P-fimbriae synthesis and induce a bacterial deformation, on both antibiotic-susceptible and antibiotic-resistant uropathogenic Escherichia coli. It is plausible that cranberry PAC prevent bacteria from adhering to the uroepithelium of the bladder, thereby blocking the ability of E. coli to infect the urinary mucosa. CONCLUSION: Cranberry treatment is a safe, well-tolerated supplement that does not have significant drug interactions. Although investigations are in the early stages, experimental and preclinical studies suggest that cranberry components may have other potential benefits, including anti-infective, anticancer and antioxidant effects, which may be considered as positive for different age-related conditions. In addition, cranberry components may induce positive cardiovascular and metabolic changes, and may improve neuropsychological activity. These effects warrant further clinical research to better place the role of cranberry products for women. PMID:19751320[PubMed - indexed for MEDLINE] Optometry. 2007 May;78(5):213-9. LAST II: Differential temporal responses of macular pigment optical density in patients with atrophic age-related macular degeneration to dietary supplementation with xanthophylls. Richer S, Devenport J, Lang JC. SourceDepartment of Veterans Affairs, Medical Center Eye Clinic, North Chicago, Illinois 60064-3095, USA. [email protected] Abstract BACKGROUND: Age-related macular degeneration (ARMD) is the leading cause of vision loss in aging Western societies. The objective of the Lutein Antioxidant Supplementation Trial (LAST) was to determine whether specific dietary interventions increased macular pigment optical density (MPOD) and visual function in patients with atrophic ARMD. The current objective of LAST II is to discern those specific characteristics that increase MPOD, i.e., that might differentiate a responder from a nonresponder. METHODS: The LAST study was a prospective, 12-month, randomized, double-masked, placebo-controlled trial conducted at an urban midwestern Veterans Administation Hospital from August 1999 to May 2001. Ninety patients with atrophic ARMD entered the study and were assigned randomly to 1 of 3 groups. Patients in group 1 received 10 mg lutein; in group 2, 10 mg lutein in combination with vitamins, minerals, and antioxidants; and in group 3, maltodextrin placebo. Changes in macular MPOD over time were evaluated. Characteristics potentially influencing MPOD included age, weight (body mass index), initial baseline values of macular pigment, and combining xanthophylls with other nutrients. RESULTS: MPOD increased with supplementation and declined slightly without supplementation (regression slopes not equal to zero in supplemented groups, P < 0.02). The highest increases in MPOD over time occurred in patients with lower baseline values of MPOD. Statistically significant increases in MPOD density were observed in the lutein group for patients with baseline MPOD <or=0.3 optical density units and up to 0.2 optical density units in the lutein plus antioxidant group. Further analysis found that none of the subjects' eyes in the lowest quartile of baseline MPOD were in the lowest quartile for change in MPOD. CONCLUSION: Noteworthy is the observation that those individuals with lowest MPOD, and in greatest need of supplementation, were also most likely to benefit from either the lutein or the lutein plus antioxidant supplementation. For those individuals who responded to supplementation, their macular pigment optical density had not ceased to increase at 12 months' duration of supplementation. The inference is that if a deficiency in macular pigment optical density is accurately diagnosed, effective interventions should be able to reestablish this prophylactic barrier. PMID:17478338[PubMed - indexed for MEDLINE] Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2007 Sep;14(5):517-28. Creatine supplementation and cognitive performance in elderly individuals. McMorris T, Mielcarz G, Harris RC, Swain JP, Howard A. SourceSchool of Sport, Exercise and Health Sciences, University of Chichester, College Lane, Chichester, West Sussex PO19 6PE, UK. [email protected] Abstract The purpose of this study was to examine the effect of creatine supplementation on the cognitive performance of elderly people. Participants were divided into two groups, which were tested on random number generation, forward and backward number and spatial recall, and long-term memory tasks to establish a baseline level. Group 1 (n = 15) were given 5 g four times a day of placebo for 1 week, followed by the same dosage of creatine for the second week. Group 2 (n = 17) were given placebo both weeks. Participants were retested at the end of each week. Results showed a significant effect of creatine supplementation on all tasks except backward number recall. It was concluded that creatine supplementation aids cognition in the elderly. PMID:17828627[PubMed - indexed for MEDLINE] Neurosci Behav Physiol. 2009 Jun;39(5):501-6. Use of Noben (idebenone) in the treatment of dementia and memory impairments without dementia. Voronkova KV, Meleshkov MN. SourceDepartment of Neurology and Neurosurgery, Russian State Medical University, Moscow, Russia. Abstract Noben (idebenone) at a dose of 120 mg per day for six months was used in the treatment of 35 patients aged 60-86 years with Alzheimer's-type dementia, mixed dementia, and memory impairments not reaching the stage of dementia. Patients were assessed on the basis of data from somatic, neurological, and psychiatric investigations, as well as neuropsychological testing and a series of psychometric and other scales and tests, before and after treatment. Significant improvements in patients' conditions on the MMSE were seen in patients with mild and moderate dementia. Improvements in daily activities were obtained in 27% of patients. Neuropsychological investigations demonstrated improvements in short-term and long-term memory and attention, with improvements in speech functions, performance of kinesthetic, spatial, and dynamic praxis tests, and in visuospatial gnosis, thought, and writing. On the CGI scale, positive treatment effects were obtained in 37% of patients, while 48% of patients remained in a stable state. PMID:19430983[PubMed - indexed for MEDLINE] Clinics (Sao Paulo). 2009;64(6):505-10. Effects of isoflavones on the skin of postmenopausal women: a pilot study. Accorsi-Neto A, Haidar M, Simões R, Simões M, Soares-Jr J, Baracat E. SourceGynecology Department, Federal University of São Paulo, São Paulo, Brazil. Abstract OBJECTIVE: The aim of this study was to evaluate the effects of isoflavones on the skin of postmenopausal women. DESIGN: A prospective study was performed with 30 postmenopausal women before and immediately after the end of treatment with 100 mg/day of an isoflavones-rich, concentrated soy extract for six months. A skin punch was performed in the gluteal region for sample collection before and immediately after the treatment program. Morphometric determination of epidermal thickness, the papillary index (wrinkling), and the amount of dermal elastic and collagen fibers was assessed. In addition, the number of blood vessels in the sample was also evaluated. The paired Student's t-test was used for statistical analysis (P < 0.05). RESULTS: Isoflavone treatment resulted in a 9.46% increase in the thickness of the epidermis in 23 patients. In addition, the papillary index was reduced in 21 women. The papillary index was inversely proportional to skin wrinkling, i.e., there were a large number of papillae after treatment. The amount of collagen in the dermis was increased in 25 women (86.2%). In 22 women (75.8%) we observed that the number of elastic fibers increased. The number of dermal blood vessels was significantly increased in 21 women. CONCLUSION: Our data show that the use of a concentrated, isoflavone-rich soy extract during six consecutive months caused significant increases in epithelial thickness, the number of elastic and collagen fibers, as well as the blood vessels. PMID:19578653[PubMed - indexed for MEDLINE] Biofactors. 2003;18(1-4):289-97. The combined use of oral and topical lipophilic antioxidants increases their levels both in sebum and stratum corneum. Passi S, De Pità O, Grandinetti M, Simotti C, Littarru GP. SourceCentro Invecchiamento Cellulare, I.D.I. (IRCCS), Rome, Italy. [email protected] Abstract The concentration of Vitamin E (vit E) and ubiquinone (CoQ10), which together with squalene (SQ), play a key role against external oxidative insult, has been shown to decrease significantly during ageing. The aim of the present study is to inquire the effect of the combined use of topical bio-cosmetics containing natural active principles (including sebum-like lipid fractions, sebum and epidermal lipophilic and hydrophilic antioxidants), and oral antioxidant supplements on the antioxidant content of sebum and stratum corneum. We therefore treated the face and the back of 50 female volunteers aged 21-40, daily for two months, with a base cream containing 0.05% ubiquinone, 0.1% vit E, and 1% squalene. In addition 50 mg of CoQ10 + 50 mg of d-RRR-alphatocopheryl acetate + 50 microg of selenium were administered orally to half of the volunteers (Group A). Group B was represented by 25 volunteers who were treated only topically. Every 15 days during treatment the levels of CoQ10, vit E and SQ were verified in sebum, stratum corneum, and plasma. The daily topical application of the cream led to a significant increase, that peaked after 60 days, of the levels of CoQ10, d-RRR-alpha-tocopherol and SQ in the sebum (Group B), without significantly affecting the stratum corneum or plasma concentrations of the redox couple CoQ10H2/CoQ10 and vit E. The concomitant oral admistration of antioxidants produced in Group A a significant increase of the levels of CoQ10H2/CoQ10 and vit E both in plasma and stratum corneum after 15 and 30 days treatment respectively, compared to Group B. However the sebum levels of lipophilic antioxidants and SQ did not show a significant increase. After the treatments, the levels of CoQ10H2/CoQ10, vit E and SQ went back to basal levels within 6-8 days in sebum, 12-16 days in the stratum corneum, and 3-6 days in plasma. Therefore topical application of the antioxidants was able to increase their level in sebum, while the concomitant oral administration also affected the levels of vit E and CoQ10 in the stratum corneum. PMID:14695946[PubMed - indexed for MEDLINE] Nutr Neurosci. 2010 Jun;13(3):116-22. Improved cognitive-cerebral function in older adults with chromium supplementation. Krikorian R, Eliassen JC, Boespflug EL, Nash TA, Shidler MD. SourceDepartment of Psychiatry, University of Cincinnati College of Medicine, PO Box 670559, Cincinnati, Ohio 45267-0559, USA. [email protected] Abstract Insulin resistance is implicated in the pathophysiological changes associated with Alzheimer's disease, and pharmaceutical treatments that overcome insulin resistance improve memory function in subjects with mild cognitive impairment (MCI) and early Alzheimer's disease. Chromium (Cr) supplementation improves glucose disposal in patients with insulin resistance and diabetes. We sought to assess whether supplementation with Cr might improve memory and neural function in older adults with cognitive decline. In a placebo-controlled, doubleblind trial, we randomly assigned 26 older adults to receive either chromium picolinate (CrPic) or placebo for 12 weeks. Memory and depression were assessed prior to treatment initiation and during the final week of treatment. We also performed functional magnetic resonance imaging (fMRI) scans on a subset of subjects. Although learning rate and retention were not enhanced by CrPic supplementation, we observed reduced semantic interference on learning, recall, and recognition memory tasks. In addition, fMRI indicated comparatively increased activation for the CrPic subjects in right thalamic, right temporal, right posterior parietal, and bifrontal regions. These findings suggest that supplementation with CrPic can enhance cognitive inhibitory control and cerebral function in older adults at risk for neurodegeneration. PMID:20423560[PubMed - indexed for MEDLINE] Nutr Res. 2008 May;28(5):315-20. Reduction of cardiovascular risk factors in subjects with type 2 diabetes by Pycnogenol supplementation. Zibadi S, Rohdewald PJ, Park D, Watson RR. SourceNutritional Sciences Department, The University of Arizona, Tucson, AZ 85721, USA. Abstract Patients with type 2 diabetes are at considerable risk of excessive morbidity and mortality from cardiovascular disease (CVD). We investigated the clinical effectiveness of Pycnogenol, a flavonoid-rich dietary supplement, in reducing antihypertensive medication use and CVD risk factors in subjects with type 2 diabetes. Forty-eight individuals were enrolled in a randomized, double-blind, placebo-controlled trial with parallel-group design. Patients were diagnosed with both type 2 diabetes and mild to moderate hypertension and were undergoing treatment with angiotensin-converting enzyme (ACE) inhibitors. Subjects were randomly assigned to receive either Pycnogenol pill (125 mg daily) or matched placebo for 12 weeks. According to the values of blood pressure (BP) measured at 2-week intervals, the pretrial ACE inhibitor dosage was left unchanged, reduced by 50%, or brought back to the pretrial dosage until a stable BP was obtained. Fasting plasma glucose, low-density lipoprotein (LDL) cholesterol, glycosylated hemoglobin (HbA1c), serum endothelin-1, and urinary albumin were evaluated monthly. Pycnogenol treatment achieved BP control in 58.3% of subjects at the end of the 12 weeks with 50% reduction in individual pretrial dose of ACE-inhibitors (P <.05). Plasma endothelin-1 decreased by 3.9 pg/mL in Pycnogenol-treated group vs 0.5 pg/mL increase in control group (P < .001). Mean HbA1c dropped by 0.8% in Pycnogenol-treated group (P < .05), whereas it decreased by 0.1% in control group. Fasting plasma glucose declined by 23.7 mg/dL in Pycnogenol-treated group vs 5.7 mg/dL in control group (P < .0001). Low-density lipoprotein cholesterol improved significantly in Pycnogenol-treated group, declining by 12.7 mg/dL (P < .001). A significant decrease in urinary albumin level was observed at week 8 compared with the control group (P < .05). However, this reduction was not significant at 12th week. After 12 weeks of supplementation, Pycnogenol resulted in improved diabetes control, lowered CVD risk factors, and reduced antihypertensive medicine use vs controls. PMID:19083426[PubMed - indexed for MEDLINE]
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