Search Framework

Oferta de Tecnologia
Difusão
Internacional
Título
COMPOUNDS WITH ANTI-PARASITE ACTIVITY (PAT13)
Referência
43304
Procura válida até
19-08-2016
Resumo
This technology concerns to the application of new compounds with a potent anti-parasite activity against
leishmaniasis causing organisms: Bisnaphthalimidopropyl (BNIP) derivatives
Descrição
Naphthalimido derivatives exhibit considerable potential anti-parasite activity. To realise this potential and to
enhance the activity of such compounds, most previous research has been focused on the modification of the
naphthalimido ring structure through increased DNA binding and cleavage.
We have now created a number of new bisnapthalimidopropyl (BNIP) derivatives characterised by the use of
natural polyamine linkers between the BNIP fragments. The family of new derivatives differ in respect of their
respective alkyl linker chain lengths and nitrogen atom content. Compared to previous derivatives, these
compounds have enhanced water solubility and now show potent in vitro and in vivo anti-proliferative effects on
the life cycle of the protozoans Leishmania infantum, Trypanosoma brucei and T. cruzi, the causative agents of
leishmaniasis, sleeping disease and Chagas disease, respectively,in humans.
Aspectos Inovadores e
Principais Vantagens da
Oferta
- Natural polyamine structures are the basis of the BNIP derivatives with alkyl linker chains;
- Enhanced water solubility due to the alkyl chain length and charge distribution;
- High yeild chemical synthetic strategies established;
- Advanced nanoformulation technologies compatibility;
- Potent in vitro and in vivo anti-trypanosomal (anti-Leishmania, anti-T.brucei and anti-T. cruzi) activity;
Fase de Desenvolvimento
Projeto iniciado
Comentários à fase de
desenvolvimento
Compounds have undergone in vitro and in vivo studies.
In vitro assays: the nanoformulation reduced the compound cellular toxicity, retained its potent anti-leishmanial
activity.
In vivo assays: the BNIP derivative nanoformulation is more effective than free compound and amphotericin B in
the spleen; in the liver the effect of the BNIP derivative nanoformulation is less pronunced.
Direitos de Propriedade
Industrial
Patente atribuída
Comentários aos Direitos de
Propriedade Industrial
Patent granted in Portugal, USA and Europe (France, Germany, Spain and United Kingdom)
Exploração de resultados de
I&D
Nenhum
Comentários à exploração de
resultados de I&D
We are seeking business partners for licensing or assignment agreement.
Tipos de Colaboração
Acordo de licenciamento
Contrato de aquisição
Tipo de parceiro procurado
Business company; investor
Área de actividade do
parceiro
Any interested in the potential of the technology
Tarefa a ser realizada
Development and commercialisation
01-10-2016
http://www.bolsatecnologia.pt
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Aplicação de Mercado
Pharmaceutical Industry
Descrição da Organização
UPorto Innovation is the Knowledge Transfer Office of University of Porto, Portugal. It is in charge of patent
exploration, marketing promising innovations and entrepreneurship opportunities, and acts as an interface with
companies.
01-10-2016
http://www.bolsatecnologia.pt
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