INSTITUTO DE PSIQUIATRIA – IPUB/UFRJ Programa de Pós

INSTITUTO DE PSIQUIATRIA – IPUB/UFRJ
Programa de Pós-Graduação em Psiquiatria e Saúde Mental - PROPSAM
CURSO DE FÉRIAS
Coordenação no PROPSAM: professores Leonardo Fontenelle e Gabriela Menezes
Disciplina com 45 horas de carga horária para Mestrandos e Doutorandos
Aberta para ouvintes com direito à Certificado
Inscrições por e-mail ([email protected]) até 12/07/2012 às 13:00 h
Neurobiologia dos Processos Volitivos
Coordenador: Prof. Murat Yücel (Melbourne Neuropsychiatry Centre & Melbourne Health, University of
Melbourne, Australia), Dr. Ben J. Harrison (Melbourne Neuropsychiatry Centre & Melbourne Health,
University of Melbourne, Australia), Dr. Hironobu Fijuwara (Department of Molecular Neuroimaging,
Molecular Imaging Center, National Institute of Radiological Sciences)
Período: 13 a 31 de Julho de 2012 (09:00 às 13:00)
Auditórios Leme Lopes & William Asmar
Aulas serão ministradas em inglês
Ementa: Este curso reúne uma série de aulas independentes que pretendem fornecer uma visão geral
sobre os aspectos neurobiológicos de transtornos psiquiátricos caracterizados por prejuízos dos processos
volitivos (e.g. abuso de substâncias, transtorno obsessivo-compulsivo e dependências comportamentais) e
seu impacto sobre a cognição e comportamento.
1) Drug Use, Teenage Brain Development & Mental Health (overview cognitive/MRI findings in
inhalants, cannabis, heroin and its implications for mental health)
2) The impact of cannabis use on cognitive functioning and brain structure: implications for
understanding the neural basis of psychosis and its clinical implications.
3) PET imaging in internet addiction
4) PET imaging in psychiatric disorders
5) Brain corticostriatal network alterations in OCD: Summary of past & current findings
Mês
Sexta
Terça
Terça Quinta Terça
Julho
13
17
24
26
31
Horário: 9 Leme William William Leme William
às 13h
Lopes* Asmar Asmar Lopes Asmar
Nota: * Aula no Centro de Estudos (início às 10:30h)
2
BIOGRAFIAS
Murat Yücel (Melbourne Neuropsychiatry Centre & Melbourne Health, University of Melbourne,
Australia): Professor Yücel’s is an authority in the area of biological psychiatry and neurobiology of drug
addiction. His research spans two main themes: (i) Understanding the neural, psychological and
biochemical basis of the “compulsive” or “addictive” behaviours seen across substance related disorders,
as well as psychiatric and neurological disorders (e.g., obsessive-compulsive disorder, schizophrenia, and
Parkinson’s disease), and: (ii) Understanding the links between heavy cannabis use, the brain and mental
health (especially psychosis). Professor Yücel has an exceptional track record of research and publication,
both in terms of quantity and quality. He has received local, national, and international media attention
and been extremely well cited relative to the number of years this work has been published drawing over
4000 citations (~1200 last year alone). Over his research career, he has been involved in obtaining >$18
million project funding as a Chief Investigator on 3 large international and 15 large national (NHMRC,
ARC) grants. Currently, he is involved in managing >$5 million in project grant funding and has >160
publications on these and related topics.
Ben J Harrison (Mebourne Neuropsychiatry Centre & Melbourne Health, University of Melbourne,
Australia): Dr. Ben Harrison is a NHMRC Clinical Research Fellow (2010-2014). He co-leads the
Affective Neuropsychiatry group at MNC and is member of the Centre’s Executive Committee. His work
principally involves the use of functional neuroimaging techniques to study the brain basis of emotional
disturbance in mood and anxiety disorders, including major depression, social anxiety disorder and
obsessive-compulsive disorder. Related to this work, he has a basic interest in the characterising the
functional role of brain corticostriatal, central autonomic and “default-mode network” systems. Dr. Ben
Harrison has an long track record of research and publication, drawing over 1000 citations. He
participates in several competitively-funded national and international research projects, in addition to
leading a current NHMRC Project Grant. He supervises post-doctoral fellows and PhD students. In
September 2012, he will commence an appointment as Senior Research Fellow.
Hironobu Fujiwara (Department of Molecular Neuroimaging, Molecular Imaging Center, National
Institute of Radiological Sciences, Chiba, Japan): Currently, Dr. Fujiwara is a researcher at Prof. Tetsuya
Suhara's laboratory, at the Molecular Imaging Center, in Chiba, Japan. He has published extensively on
the neuroanatomical correlates of impaired social cognition in schizophrenia. Currently, his research focus
is on the elucidation of the pathophysiology of neuropsychiatric diseases, e.g., addiction, schizophrenia,
depression, and dementia, using PET and MRI. PET technique with molecular probes enables us to
measure the function of neurotransmission in humans. Activation studies using MRI with psychological
and physiological tasks allow the investigation of regional neural function. The aim of Dr. Fujiwara's
research work is the establishment of bio-markers for early diagnosis and evaluation of treatment using
PET combined with MRI in clinical studies.
REFERÊNCIAS
Yücel M, Bora E, Lubman DI, Solowij N, Brewer WJ, Cotton SM, Conus P, Takagi
MJ, Fornito A, Wood SJ, McGorry PD, Pantelis C. The impact of cannabis use on
cognitive functioning in patients with schizophrenia: a meta-analysis of existing
findings and new data in a first-episode sample. Schizophr Bull. 2012
Mar;38(2):316-30.
Harrison BJ, Soriano-Mas C, Pujol J, Ortiz H, López-Solà M, Hernández-Ribas R,
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Deus J, Alonso P, Yücel M, Pantelis C, Menchon JM, Cardoner N. Altered
corticostriatal functional connectivity in obsessive-compulsive disorder. Arch
Gen Psychiatry. 2009 Nov;66(11):1189-200.
Fontenelle LF, Oostermeijer S, Harrison BJ, Pantelis C, Yücel M.
Obsessive-compulsive disorder, impulse control disorders and drug addiction:
common features and potential treatments. Drugs. 2011 May 7;71(7):827-40.
Bora E, Harrison BJ, Fornito A, Cocchi L, Pujol J, Fontenelle LF, Velakoulis
D, Pantelis C, Yücel M. White matter microstructure in patients with
obsessive-compulsive disorder. J Psychiatry Neurosci. 2011 Jan;36(1):42-6.
Fontenelle LF, Harrison BJ, Pujol J, Davey CG, Fornito A, Bora E, Pantelis C,
Yücel M. Brain functional connectivity during induced sadness in patients with
obsessive-compulsive disorder. J Psychiatry Neurosci. 2012 Jul;37(4):231-40.
Kubota M, Miyata J, Yoshida H, Hirao K, Fujiwara H, Kawada R, Fujimoto S,
Tanaka Y, Sasamoto A, Sawamoto N, Fukuyama H, Murai T. Age-related cortical
thinning in schizophrenia. Schizophr Res. 2011 Jan;125(1):21-9.