Apresentação do PowerPoint

Chemoradiation as a treatment
for the Buschke-Löwenstein
Tumour: A case report.
Santos, M.H.1; Di Tommaso, R.A.S.1; Haji Junior, A.C.1; Medeiros, F.Q.2; Baldino, L.3; Correa Junior, M.A.R. 4
1.
2.
3.
4.
Médico(a) Residente de Cancerologia Cirúrgica - Fundação Centro de Controle de Oncologia do Estado do Amazonas – FCECON.
Oncologista clínico - Fundação Centro de Controle de Oncologia do Estado do Amazonas – FCECON.
Radioterapeuta - Fundação Centro de Controle de Oncologia do Estado do Amazonas – FCECON.
Cirurgião oncológico - Fundação Centro de Controle de Oncologia do Estado do Amazonas – FCECON.
Introduction
Objectives
The Buschke-Löwenstein tumour
The purpose is to report a rare
(BLT) or giant condiloma acuminata (GCA) case of a Buschke-Löwenstein tumour of
is a rare sexually transmitted disease the vulva treated with chemoradiaton.
caused by Human papilloma virus (HPV)
and characterised by invasive growth. The
BLT generally presents like an exophytic
tumour of the genital or perianal area,
preferentially
in
men
with
immunodeficiency diseases and rarely
occurs in woman. We present a case
report of a 18-years-old woman with
giant Buschke-Löwenstein tumour of the
vulva
succesfully
treated
with
chemoradiation.
CASE REPORT
A female patient, 18, referred to
the pelvic surgery service of our hospital,
with large warty lesions, vegetating,
affecting vulva extending to the lower
third of the vagina and perineum. No
history of sexually transmitted diseases
(STDs) and seronegative for HIV, reported
four months evolution, unresponsive to
topical treatment with trichloroacetic acid
solution and cryotherapy. She complained
of unpleasant odor, local pain and
ocasionally bleeding.
Physical examination showed bilateral
inguinal lymph node, vaginal and rectal
examination were not tolerated because
of the local pain. Biopsy held that, under
the microscope revealed the diagnosis of
condyloma acuminata.
After multidisciplinary discussion,
treatment was initiated with radiation
(45Gy) associated with platinum-based
chemotherapy (cisplatin). It showed
excellent response, with complete
remission of the lesion.
CASE REPORT
DISCUSSION
CONCLUSION
Giant condyloma acuminatum
Chemoradiation is an interesting
(GCA), first described by Buschke- alternative treatment, showing good
Löwenstein in 1925, is a large, exophytic, response and avoiding a mutilating
cauliflower-like lesion, which can be surgical intervention.
found on any anogenital mucosal surface.
References
There is no consensus in the literature
Safi, F., et al. Management of peri-anal giant condyloma Acuminatum: A
regarding the standard treatment, which •case
report and literature review. Asian Journal of Surgery (2013) 36, 43-52.
includes surgery, topical medications,
• Sobrado, C.W., et al. Radiation-Induced TotalRegression of a Highly Recurrent
cryotherapy,
radiotherapy
and Giant Perianal Condyloma. Dis Colon Rectum 2000;43:257-260.
chemotherapy. Generally radical excision • Tan, X. et al. Giant condyloma acuminatum of the vulva. International
is performed to avoid malignant Journal of Infectious Diseases 14 (2010) e455–e456
transformation, although with a high
number of recurrences.