Curriculum vitae

Curriculum vitae
Name: André Luiz Loureiro Weigert
Date and Place of Birth: July, 18th, 1960; Rio de Janeiro, Brazil
Citzenship: Portuguese and Brazilian
Degree: Medical Doctor by the Universidade Clássica de Lisboa with Honors (“Media:
18 valores”; “Muito Bom com Louvor e Distinção”; top 1% score) in September 1984.
PhD equivalent (Doutoramento) in Pharmacology and Medicine at the Universidade
Clássica de Lisboa with Honors (“Louvor e Distinção”) in 1999.
Post-Graduate Training:
Hospital Santa Maria, Lisbon (Fev 85- Dec 86): Internship
Hospital de Santa Cruz, Carnaxide/Lisbon (Jan 87-June 88): Residence in Nephrology
Baylor College of Medicine (July 88- June 92): Residence in Internal Medicine through
the Clinical Investigator pathway. Included 3 months of Nephrology (under supervision
of Dr. Garabed Eknoyan) and 6 months as Chief Medical Resident at the Houston
VAMC
American Board of Internal Medicine certified in 1992.
University of Colorado (July 92- June 95): Fellowship in Nephrology and Hypertension,
having Dr. Robert W. Schrier as his Mentor; extensive dialysis (hemo, PD, continuous
methods) with Drs Alan Alfrey, David Spiegel and Isaac Teitelbaum.
American Board of Nephrology and Hypertension certified in 1996.
Elected Fellow of the American College of Physicians in 1999
Obtained the Degree of Specialist in Clinical Pharmacology in Portugal (September
2008)
Basic Cardiovascular Research on endothelial function: 1) Center for Experimental
Therapeutics, Baylor College of medicine (Mentor: Paul M. Vanhoutte); 2) University
of Colorado (Mentor: Robert W. Schrier). During these periods participated in the
evaluation and follow up of numerous patients enrolled in clinical trials.
Presented numerous posters and oral presentations as well as conferences both in
Portugal and abroad, namely in USA, Brazil, Spain, Singapore, Sweden, India, Angola,
Mozambique
Some publications in the JASN, KI and other relevant peer-reviewed journals.
Participation in several clinical trials on immunosupressants (ex: Rapamune 4337 trial)
as well as trials related to the use of sevelamer, darbepoietin and cinacalcet. Currently,
principal investigator at one site of the EVOLVE trial on cinacalcet impact on
cardiovascular events. Co-author in the related article at the New Engl J Med.
Postgraduate Course on Economic Evaluation of Medicines by the “Instituto Superior
de Economia e Gestão” and the Faculty of Pharmacy, University of Lisbon (2006)
Member of the Therapeutics and Pharmacology Committee of Hospital S. Cruz and of
the Centro Hospitalar de Lisboa Ocidental from 2007 until February 2014.
Organizer of the 1st and 2nd Conferences for the ISN COMGAN/Global Outreach
Conference on the Prevention of Renal and Cardiovascular Diseases in Luanda, Angola
respectively in November 2006 and in June 2010 (the latter included in the First
Congress of the Angolan Society of Nephrology. Participated in October 2011 in the
ISN GO CMEs in Maputo, Mozambique and Lusaka, Zambia, giving 3 conferences in
each. Participation at the CME in Kinshasa, Congo in Deceember 2013 (giving 4
conferences in French).
Current functions:
1) Senior Nephrologist (Assistente Graduado) at the Hospital de Santa Cruz
/Centro Hospitalar de Lisboa Ocidental (C.H.L.O.), Lisbon
2) Assistant Professor of Pharmacology, University of Lisbon
3) Medical Director of the Eurodial, Gaeiras/Óbidos, dialysis center (with about
170 patients undergoing chronic hemodialysis)
4) Davita's Clinical Medical Officer (CMO) for Portugal since August 2013.
5) Member of the International Society of Nephrology Commission for Global
Advancment of Nephrology/Global Outreach (ISN GO), Portuguese Society
Tranplantation (SPT), Portuguese Society of Nephrology (SPN), American
Society of Nephrology (ASN) and Associação Brasileira de Transplante de
Orgãos (ABTO).
6) Member of the Direction of the Portuguese Society of Transplantation (“Vogal
da Direção”) since January 2013.
Representative published papers:
A L Weigert, E C Lynch :"Striking "FMG" from our vocabulary."Annals of
Internal Medicine. 1992; 117(8):699
M Niederberger, P Ginès, P Tsai, P Y Martin, K Morris, A Weigert, I
McMurtry, R W Schrier Increased aortic cyclic guanosine monophosphate
concentration in experimental cirrhosis in rats: evidence for a role of nitric oxide
in the pathogenesis of arterial vasodilation in cirrhosis. Hepatology . 1995;
21(6):1625-31
A L Weigert, E M Higa, M Niederberger, I F McMurtry, M Raynolds, R W
Schrier Expression and preferential inhibition of inducible nitric oxide synthase
in aortas of endotoxemic rats. Journal of the American Society of Nephrology :
JASN. 1995; 5(12):2067-72
P Y Martin, D L Xu, M Niederberger, A Weigert, P Tsai, J St John, P Gines, R W
Schrier Upregulation of endothelial constitutive NOS: a major role in the increased
NO production in cirrhotic rats. The American journal of physiology. 1996;
270(3 Pt 2):F494-9.
A L Weigert, P Y Martin, M Niederberger, E M Higa, I F McMurtry, P Gines, R W
Schrier Endothelium-dependent vascular hyporesponsiveness without detection of
nitric oxide synthase induction in aortas of cirrhotic rats. Hepatology. 1996;
22(6):1856-62
A L Weigert, P Y Martin, R W Schrier Vascular hyporesponsiveness in cirrhotic rats:
role of different nitric oxide synthase isoforms. Kidney international.
Supplement. 11/1997; 61:S41-4.
A L Weigert, A I Schafer Uremic bleeding: pathogenesis and therapy. The
American journal of the medical sciences. 1998; 316(2):94-104.
O Valdez, A Gaspar, J Dickson, A Weigert, D Machado Cytomegalovirus infection
resistant to ganciclovir in a renal transplant patient. Transplantation
proceedings. 2003; 35(3):1081-2.
A L Weigert, A Pires, T Adragão, E Cardoso, C Cardoso, R Sancho, H
Trindade, M Serpa Pimentel, A Casqueiro, D Machado Human herpes virus-8
serology and DNA analysis in recipients of renal allografts showing Kaposi's
sarcoma and their respective donors. Transplantation proceedings. 2004;
36(4):902-4.
Raquel Dourado, Pedro de Araújo Gonçalves, Manuel Almeida, André Weigert,
Margarida Bruges, Augusta Gaspar, Acácio Pita Negrão, Domingos Machado,
Belarmino Clemente, Rui Teles, Francisco Pereira Machado, Aniceto
SilvaPeripheral artery disease: a cause of refractory hypertension after renal
transplantation. Revista Portuguesa de Cardiologia 2008; 27(3):353-7.
L Parreira, M Bruges, A Gaspar, A Weigert, D MachadoPrevention of
cytomegalovirus disease in renal transplantation: single-center
experience.Transplantation proceedings. 2009; 41(3):877-9.
J A Gonçalves, C Jorge, A Atalaia, P Matias, M Bruges, R Birne, J Dickson, A Weigert,
D Machado New law of renal transplantation in Portugal associated with more
acute rejection episodes and higher costs. Transplantation proceedings.
10/2012; 44(8):2276-9.
Ana Natario, Patricia Matias, André Weigert “An update on immunosupression
for the HIV-positive kidney transplant recipient” Port J Nephrol Hyperte 2012;
26 (2):139-147
Ana Natario, Bruno Rodrigues, Patricia matias, Cristina Jorge, Margarida Bruges, Rita
Birne, Ana Miranda, Kamal Mansinho, Domingos Machado, André Weigert “Renal
transplantation in an HIV-2 positive recipient in Portugal” Port J Nephrol Hyperte
2012; 26 (2): 175-178
Pedro de Araújo Gonçalves, Manuel de Sousa Almeida, Patricia Branco, Augusta
Gaspar, Hélder Dores, Maria Salomé Carvalho, Maria João Andrade, André Weigert, J
osé Diogo Barata, Angela Canha Gomes, Luís Raposo, Henrique Mesquita Gabriel, Rui
Campante Teles, Miguel Mendes Renal sympathetic denervation for treatment of
resistant hypertension. Revista Portuguesa de Cardiologia 2012; 31(10):671-675.
The EVOLVE Trial Investigators (Supplmentary Appendix) Effect of cinacalcet on
cardiovascular disease in patients undergoing dialysis. New Engl J Med 2012,
367:2482-94