Biomedical Sciences - Weiterbildung

Biomedical Sciences
Diploma of Advanced Studies (DAS)
or Certificate of Advanced Studies (CAS)
Albert-Ludwigs-Universität Freiburg
Manual (Modulhandbuch)
Juli/July 2012
University of Freiburg
Prof. em. Dr. Drs. h.c. Roland Mertelsmann
University Medical Center
Dept. of Hematology and Oncology
in cooperation with
Freiburg Academy of Continuing Education (FRAUW)
UNIVERSITY OF FREIBURG .......................................................................................................................... 0 FREIBURG ACADEMY OF CONTINUING EDUCATION ......................................................................................... 0 1. PROGRAM .............................................................................................................................. 2 2. STRUCTURE AND ORGANISATION ................................................................................... 2 2.1. RESPONSIBLE PERSONS ....................................................................................................................... 2 METHODS OF INSTRUCTION AND STUDYING TECHNIQUES ................................................................................. 3 LANGUAGE ............................................................................................................................................. 3 2.2. FORM AND LENGTH OF THE PROGRAM ............................................................................................. 3 2.2.1. Workload ......................................................................................................................... 3 2.2.2. Examinations and Grading .............................................................................................. 3 2.3. DEGREE AND CREDITS ................................................................................................................... 3 3. OVERVIEW OF MODULES ............................................................................................... 5 3.1. MOLECULAR & CELLULAR BIOLOGY (MODULE 1) ............................................................................... 5 3.2. IMMUNOLOGY & PATHOLOGY (MODULE 2) ...................................................................................... 6 3.3. PHARMACOLOGY & TOXICOLOGY, MOLECULAR CARDIOLOGY AND MOLECULAR ONCOLOGY (MODULE 3) ........................................................................................................................... 8 3.4. SPECIAL KNOWLEDGE FOR LIFE SCIENCES: MATERIALS & MICROSYSTEMS, STATISTICAL BIOINFORMATICS/MODELING IN SYSTEMS BIOLOGY (MODULE 4) .................................................... 9 3.5. LABORATORY RESEARCH 1 & 2 (MODULE 5) ................................................................................... 11 3.6. ADDITIONAL WORKLOAD ............................................................................................................. 11 Manual „Biomedical Sciences“
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1. Program
Biomedical sciences combine the knowledge and questions of experimental medicine
with the methods of molecular biology and cell biology. This international program is
designed as an intensive time of studies and research with a specific and practical
training that qualifies for success in academia or the private sector. IMBS modules are
treating following topics: Pharmacology and Toxicology, Materials and Microsystems,
Molecular Medicine, Immunology, Pathology, Molecular Oncology, Molecular and Cellular
Biology and an module in Statistical Bioinformatics.
In addition, participants can chose a personal research project. Each research project is
individually supervised and involves eight weeks of lab work, that is seven weeks of
experimental work followed by week of data analysis and a written lab report in the format
of a scientific research publication.
The program is tailored to the interests of international graduate students with
professional experience. Applicants should hold at least a Bachelor's degree or
equivalent degree in biology, biochemistry, medicine, chemistry, or related fields1.
2. Structure and Organisation
2.1. Responsible Persons
Prof. em. Dr. Drs. h.c. Roland Mertelsmann, Scientific Director
Registration, counseling, coordination: International Program in Biomedical Sciences
(IMBS)
Ms. Yvonne Weigand
University Medical Center Freiburg, Dept. of Hematology and Oncology
Hugstetter Straße 55, D 79106 Freiburg, Germany
Tel.: +49 (0)761/270-37890 // Fax: +49 (0)761/270-32060
[email protected]
Teaching Staff
The teaching staff is composed of professors and lecturers of the
Albert-Ludwigs-University and the University Medical Center of
Freiburg/Breisgau as well as of the University of Furtwangen/Black
Forest.
1
Master, Diploma or other foreign degrees Manual „Biomedical Sciences“
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Methods of instruction and studying techniques
Language
English
Presence
lectures and classes
group presentations
practical lab-work
Self Studies
scientific reading
preparation of presentations in groups
preparation of intermediate exam
practical lab-work
consolidation of acquired knowledge
2.2. Form and Length of the Program
2.2.1.
Workload
Please note: according to the intensive format of a full time program (summer school) and in
order to offer a highly flexible program, module sizes may differ from the usual extent.
Modules off 2 CP, which is of 50 hours workload per week are offered as well as modules of
4 to 6 CP with a duration of 2 to 3 weeks of intensive course.
An additional workload is mentioned for times of preparation and study concerning
participants from abroad within the IMBS Summer School Program (see 3.5).
2.2.2.
Examinations and Grading
Examinations:
written exams
written lab-reports
Intermediate Exam
oral exam (intermediate exam)
Grading Scale:
1,0 / 2,0 / 3,0 / 4,0 / 5,0 (failed)
2.3. Degree and Credits
The program concludes either with a Diploma of Advanced Studies "Biomedical
Sciences" (DAS) or with a Certificate of Advanced Studies (CAS) "Biomedical
Sciences” according to the workload and number of modules the student chooses.
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Diploma of Advanced Studies
For DAS a total of 30 credit points (CP) in the European Credit Transfer System (ECTS) is
awarded.
Alternatively:
Certificate of Advanced Studies
For CAS a total of at least 10 credit points (CP) in the European Credit Transfer System
(ECTS) is awarded.
Credit Points: Requirements
For being awarded credit points the following is required:
- preparation according to the specifications and material provided by the professors
- active participation in class
- reading and self-study
- active participation in group presentations
- written and oral examinations
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3. Overview of Modules
Module 1: Molecular & Cellular Biology
2 CP
Module 2: Immunology and Pathology2
4 CP
Module 3: Pharmacology & Toxicology, Molecular
6 CP
Cardiology and Molecular Oncology
Module 4: Special Knowledge for Life Sciences:
4 CP
(Materials & Microsystems; Statistical
Bioinformatics/Modeling in Systems
Biology)
Module 5: Laboratory Research 1 & 2
14 CP
3.1. Molecular & Cellular Biology (Module 1)
Lecturer: Prof. Dr. Christoph Borner
There will be study of apoptosis in eukaryotic cells. Scientific methods will be explored:
Individual bench work under supervision, statistical analysis, scientific lab report and
critical evaluation of data.
Learning Outcomes
-
Knowledge of cellular and biochemical methods on cellular models
-
Knowledge of rules and safety measure of lab work and ability to work
under sterile conditions
-
Statistical analysis of the data
-
Proper logging
Workload
a total workload of 50 hours, distributed over:
Presence:
8,5 hrs/day: in the lab
42,5 hrs/week
Self-Study:
1 h/day: data analysis and documentation and 2,5 5 hrs/week
hrs/week reading
2,5 hrs/week
_____
Total per week:
50 hrs
2
Occasionally or alternatively offered: additional contents of Neurology Manual „Biomedical Sciences“
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Credits:
2
3.2. Immunology & Pathology (Module 2)
This module contains two submodules: An immunologic submodule and a pathologic
submodule.
The immunologic submodule comprises lectures on special topics in advanced cellular
and molecular immunology and pathology. It will show techniques in cellular immunology
such as chromium release, proliferative assays and ELISPOT. It introduces also to
multicolor flow cytometry (including practical exercises). Students will learn about tumor
immunology, including antigens that can be recognized on human tumors; it will show
development and recognition by mouse and human Natural Killer cells (NK cells) and
bring light to the role of NK cells in graft-versus host disease. Other topics are allergic
contact dermatitis, bacterial endotoxin and the innate immune system, the role of
neutrophils in acute GvHD, regulatory T cells in human disease and antigen presentation
as well as immune tolerance in the intestine.
The pathologic submodule deals with the following: Clinical pathology diagnoses and
classifies diseases based on histological, cytological and molecular methods to
understand the principles and the development of diseases, f.ex. the causes of cancer,
DNA repair and cancer, molecular cytogenetics of cancer, oncogenes and tumor
suppressor genes, the cancer cell cycle and cellular immortalization and telomerase
activation in cancer. This submodule will show signaling pathways in cancer as well as the
spread of tumors. Apoptosis (molecular physiology and significance for cancer
therapeutics), stem cells, hematopoiesis, leukemia and animal models of cancer are
discussed.
Lecturers
Immunology: Prof. Dr. Paul Fisch
Hans-Eckart Schafer
Andreas Diefenbach
Andreas Boehmler
Beckman Coulter
Stefan Martin
Marina Freundenberg
Robert Zeiser
Reinhard Marks
Philipp Rauf
Thomas Boehm
Pathology:
Prof. Dr. Martin Werner
Dr. Konrad Aumann
Learning Outcomes
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(1)
- Participants have an overview of flow cytometry and understand the
scientific presentation of flow cytometry data. They understand the role
of different components of the immune system in human disease.
-
Evolution of adaptive immunity is a concept understood by participants.
-
Participants understand general principles of etiology and
pathogenetics of diseases and the methods of pathological
examination.
-
They are able to interpret the results of the examinations within an
interdisciplinary context.
(2)
-
Participants have deeper knowledge on the following subjects:
Role of pathology
Methods in Pathology
Methods in Molecular Pathology
Immunological diseases
Hematological diseases
Tumorpathology
Neuropathology
Molecular genetics
Cellular adaptations, cell injury, and cell death
Acute and chronic inflammation
Tissue renewal and repair : regeneration, healing, and fibrosis
Hemodynamic disorders, thromboembolic disease and shock
Genetic disorders
Workload
a total workload of 100 hours, distributed over:
Presence:
(1) 6 hrs/day: lectures/seminars
5 hrs/week: presentations by the students (20
minutes each)
(2) 6 hrs/day: lessons
4 hrs/week: exam preparation
1 h/week: exam
Self-Study
(1) 5 hrs/week: self-study and preparation time of
the own presentation
2 hrs/day: self-study
(2) 2 hrs/day: self-study
13 hrs/week: self-study, preparation seminars
(1) 35 hrs/week
(2) 35 hrs/week
(1) 15 hrs/week
(2) 15 hrs/week
____
Total per week:
50 hrs
Credits:
4
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3.3. Pharmacology & Toxicology, Molecular
Cardiology and Molecular Oncology (Module 3)
The first part of this module offers basic and advanced knowledge about pharmacological
studies of interaction between foreign substances (drugs) and organisms (biological
systems).
The second part of this module is focusing on recent key aspects of translational research
in cellular and molecular biology and medicine. The participants will learn about basic
immunologic and inflammatory mechanisms promoting atherosclerosis, and the metabolic
syndrome as well as about the fundamental processes governing cardiac metabolism and
dysfunction.
They will learn about recent key aspects of translational research in cellular and molecular
biology of cancer covering various areas of tumor genesis.
Lecturers
Pharmacology &
Toxicology:
Prof. Dr. Klaus Aktories
Prof. Dr. Norbert T. Klugbauer
PD Dr. Joachim Orth
PD Dr. Ralf Gilsbach
Prof. em. Dr. Dieter Meyer
Molecular Cardiology: PD. Dr. Andreas Zirlik
Dr. Dennis Wolf
Dr. Sonja Hergeth
Dr. Heiko Bugger
Natalie Hoppe
Alexandra Ortiz
Molecular Oncology: Prof. Dr. Ralph Wäsch
PD Dr. Christine Dierks
Prof. Dr. Monika Engelhardt
Dr. Milena Pantic
Dr. Stefan Zimmermann
Learning Outcomes
(1)
- Participants have knowledge of the mode of action of drugs and
poisons, in order to allow a scientifically based, rational
pharmacotherapy and treatment of poisoning.
 Receptor tyrosine kinases
 Bacterial toxins
 GPCR Signaling
 Voltage-gated ion channels
 GTPases
- They have obtained knowledge of the mode of interaction of
microsystems, surfaces and materials.
(2) Participants know about basic molecular, inflammatory and immune
mechanisms in atherosclerosis, the metabolic syndrome and cardiac
energy metabolism / experience and in state-of-the-art techniques in
the field.
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(3)
-
Basic concepts and techniques in the field of molecular biology of
cancer are understood.
Participants have the ability to get into specific topics of the field by
reading current publications and to interpret and communicate the
data, which should be applicable to other subjects in life science. -
Workload
a total workload of 150 hours, distributed over:
Presence:
(1) 3 hrs/day: Lectures and seminars
2 hrs/day: preparation of oral presentation
3 hrs/day: practical course:
(2) 6 hrs/day: seminar
(3) 8 hrs/day: lecture, group work, presentation
Self-Study:
(1) 2 hrs/day: self-study
(2) 4 hrs/day: self-study estimated
(3) 2 hrs/day: self-study
Credits:
(1) 40 hrs/week
(2) 30 hrs/week
(3) 40 hrs/week
(1) 10 hrs/week
(2) 20 hrs/week
(3) 10 hrs/week
_____
Total per week:
50 hrs
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3.4. Special Knowledge for Life Sciences: Materials & Microsystems,
Statistical Bioinformatics/Modeling in Systems Biology (Module 4)
Special knowledge and state of the art methods are required to be able to do
research in Biomedical Sciences.
The first submodule will show the use of DNA-Chip for the detection of bacteria as
well as protein adsorption to surfaces as observed by surfaces plasmons. Plasmons
can be described as an oscillation of free electron density. Position and intensity of
plasmon absorption and emission peaks are affected by molecular adsorption.
Students will be watching cells on microstructured surfaces with the help of Atomic
force microscopy (AFM) and they will be probing surfaces with small tips.
Research laboratories organize journal clubs for all researchers in the lab to help
them keep up with the literature produced by others who work in their field. Taking
part in the journal club helps of the biomedical sciences program makes
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participants become more familiar with the advanced literature and data in their field
of study. This helps to rapidly improve the students' skills of understanding and
debating current topics of active interest in their field.
The second submodule deals with modeling and the application of statistical
analysis methods in order to train the interpretation of the results. The course will
teach the following:
 Multiple testing
 Unsupervised statistical learning
 Supervised statistical learning
Lecturers:
Materials/Microsystems:
Prof. Dr. Jürgen Rühe
Dr. Holger Klapproth
Dr. Oswald Prucker
Dr. Thomas Brandstetter
Dr. Karen Lienkamp
Statistical Bioinformatics:
Prof. Dr. Matthias Kohl
Prof. Dr. Knut Möller
Learning Outcomes
(1) Students gain individual laboratory skills.
They become acquainted with the assessment and evaluation of
scientific literature and also with interdisciplinary work.
(2) Students know how important statistical analysis methods have to
be applied and how the results have to be interpreted.
Students will get familiar with open source statistical software for
bioinformatics, i.e. the statistics software R (free, non-commercial
implementation of statistical programming language S) and
Bioconductor, using the R statistical programming language. Workload
a total workload of 100 hours, distributed over:
Presence:
(1) 4 hrs/day: laboratory work
3 hrs/day: lectures
(2) 6 hrs/day: lectures
Self-Study
(1) 3 hrs/day: self-study (journal club work)
(2) 4hrs/day: self-study, case-studies, exercises
(1) 35 hrs/week
(2) 30 hrs/week
(1) 15 hrs/week
(2) 20 hrs/week
____
Total per week:
50 hrs
Credits:
4
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3.5. Laboratory Research 1 & 2 (Module 5)
Lab Research includes an intensive period of eight weeks respectively two times
four weeks of laboratory work including documentation, self study and
discussion on methods and results. Participants shall follow individual projects in
their chosen laboratory/laboratories.
Learning Outcomes

Participants learn in depth about methods and documentation
during hands-on work

They should be able to adapt methods to specific questions.

They understand all principles of laboratory work in the chosen
laboratory/laboratories.
Workload
Workload
Credits:
8 weeks
(4 weeks)
40 hrs/week: Laboratory work
including documentation
320 hrs
(160 hrs)
3,5-4 hrs/week: Self-study and
discussion
30 hrs
(15 hrs)
__________________
350 hrs
(175 hrs)
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3.6. Additional Workload
Workload
Intercultural Training and
Scientific German Course
Preparation for Intermediate
Exam
Intermediate Exam (one day)
Two Weeks of Self Study
(consolidation
of
acquired
knowledge)
Evaluation of the program and
editing of final written report
Total
Manual „Biomedical Sciences“
48 hrs
40 hrs
10 hrs
50 hrs
02 hrs
150 hrs
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