Medizinische Universität Innsbruck

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The 15th COSBID Meeting Innsbruck
September 13th-14th 2013
Department of Neurology
Division of Neurocritical Care
Anichstrasse 35, A-6020 Innsbruck
COSBID 2013 - The 15th COSBID Meeting Innsbruck
General Information
Welcome,
Welcome to the 15th COSBID meeting Innsbruck. COSBID is an
international cooperation of clinical and basic neuroscientists working in
various participating centres in Europe and America.
The goal of COSBID is to study mechanisms of secondary brain injury,
most notably the relevance of repeated depolarizations in the acutely
injured brain for local tissue damage and the longterm outcome of
patients.
The longterm persepective is to investigate, whether treatment of brain
injury depolarizations may represent a potential target for
neuroprotection.
Ongoing clinical studies cover:
(1) Traumatic brain injury (TBI);
(2) Aneurysmal subarachnoid hemorrhage (SAH);
(3) Malignant hemispheric stroke (MHS);
(4) Intracerebral hemorrhage (ICH);
In this current meeting we will provide an update on ongoing and
finished clinical studies, present latest data on cortical depolarizations
and multimodal neuromonitoring in clinical and experimental models of
acute brain injuries.
With best regards
PD R. Helbok
Univ. Prof. E.Schmutzhard
Univ. Prof. C. Thomé
General Information
Organizing Committee
R. Helbok ([email protected])
E. Schmutzhard
C. Thomé
Date
13th-14th September 2013
Venue
Medizinzentrum Anichstraße, (MZA, House Nr. 1), Lecture Hall (Hörsaal 1)
Anichstrasse 35
A-6020 Innsbruck
Registration Fee
€ 100,(includes registration, coffee breaks, dinner)
Bank Transfer:
Please make drafts payable in Euro only to:
Account Name: Medizinische Universität Innsbruck, Univ.-Klinik für Neurologie
Bank Details: Bank für Tirol und Vorarlberg, Innrain 100, A-6020 Innsbruck
Bank Code: 16000, Account Number: 100415593
Reason for Payment: D-151900-016-012 „Neurology- COSBID“
IBAN Number: AT071600000100415593 BIC Code: BTVAAT22
Contact
Mag. Gabriele Schobesberger
T: +43-512-504-23988
F: +43-512-504-24243
[email protected]
www.i-med.ac.at/neurologie
Programme
Friday, September 13th 2013
08:00 – 09:00
Registration
09:00 – 09:15
Welcome and Introduction
W. Poewe, C. Thomé, E. Schmutzhard, R. Helbok
09:15 - 10:00
Basics and Definition
J. Dreier, M. Fabricius
09:15 - 09:35
Analysis of spreading depolarizations in the electrocorticogram
09:35 – 10:00
On filters, baselines and artifacts in ECoG
M. Winkler (Charité Berlin)
M. Fabricius (Copenhagen)
10:00 - 10:45
Spreading Depolarizations – an Update
10:00 - 10:15
Subarachnoid hemorrhage
10:15 – 10:30
Traumatic brain injury
10:30 – 10:45
Ischemic Stroke
J. Dreier (Charité Berlin)
J. Hartings (Cincinnati)
R. Graf (MPI Cologne)
10:45 - 11:15
Coffee
11:15 - 12:20
Multimodal Neuromonitoring
J. Hartings, R. Helbok
11:15 - 11:35
Introduction neuromonitoring
11:35 - 11:55
ECoG with the Moberg Component Neuromonitoring System
11:55 - 12:10
Early brain injury in SAH patients
12:10 - 12:25
Cerebral hyperkaliemia and metabolic distress after aSAH
R. Helbok (Innsbruck)
A.J.Schiefecker (Innsbruck)
A.P. Antunes (Innsbruck/Lisbon)
12:25 - 13:30
13:30 - 14:30
Lunch Break
Spreading Depolarizations and Multimodal Neuromonitoring
O. Sakowitz, C. Thomé
13:30 - 14:00
Spreading depolarizations and brain homeostasis: metabolism,
CBF,PbtO2
14:00 - 14:30
The relationship between spreading depolarization and ictal
epileptic activity
O. Sakowitz (Heidelberg)
J. Dreier (Charité Berlin)
Programme
Friday, September 13th 2013
14:30 - 16:00
Spreading Depolarizations and Clinical Research
J. Dreier, E. Schmutzhard
14:30 - 14:50
Optimising and validating CSD detection with a depth electrode
array inserted via bolt access
14:50 - 15:05
Hemodynamic responses to cortical spreading depolarization in
severe traumatic brain injury patients
15:05 - 15:20
Spreading depolarization and the low-frequency pressure
reactivity index (L-PRX) after acute brain injury
15:20 - 15:35
Excitotoxicity and metabolic changes in association with
spreading depolarization in patients with malignant hemispheric
stroke
15:35 – 16:00
Spreading depolarizations in intracerebral hemorrhage –
preliminary Innsbruck experience and The COSBID-ICH Project
T. Jeffcote (London)
J. Hinzman (Cincinnati)
M. Seule, O. Sakowitz (Heidelberg)
J. Woitzik (Charité Berlin)
R. Helbok, M. Fabricius (Innsbruck/Copenhagen)
16:00 - 16:30
Coffee
16:30 - 16:50
Center TBI
A.J. Strong, R. Beer
16:30 – 16:50
Center TBI - an Update
O. Sakowitz
16:50 - 18:00
COSBID work in London: progress and plans
A.J. Strong, R. Beer
16:50 - 17:10
Update on the Wellcome Trust Brain Injury Index Project
(advanced, novel microfluidics and sensor technologies)
17:10 - 17:30
Experience with use of the Cybula/Uni York portal for CSD and
secondary brain injury research projects
17:30 - 17:45
Extraction of high frequency, high resolution waveform ICP data
from bedside monitors
17:45 – 18:00
Localising a monitoring site on follow-up CT scans
M.G. Boutelle (London)
A.J. Strong (London)
S. Mulcahy (London)
T. Jeffcote (London)
19:30
Dinner Restaurant Glasmalerei, Glasmalereistrasse 5, 6020 Innsbruck
Programme
Saturday, September 14th 2013
9:00 - 10:45
Spreading Depolarizations and Animal/Experimental Research
B. Shuttleworth, J. Woitzik
09:00 - 09:35
Mechanisms contibuting to spreading depolarizations
09:35 - 10:00
The role of excitotoxicity vs. spreading depolarizations in
ischemic injury
10:00 - 10:15
Energy budget of CSD - implications on regulation of cerebral
metabolism
10:15 - 10:30
Multi-modal imaging of spreading depolarizations in rat models
of cerebral ischemia
10:30 - 10:45
Spreading depolarization and its modulation by ketamine in the
porcine brain
B. Shuttleworth (New Mexico)
J. Hinzman (Cincinnati)
H. Backes, D. Feuerstein, M. Gramer, M. Takagaki, R. Graf (Cologne)
E. Farkas, Z. Bere, D.L. Clark, F. Bari (Szeged, Hungary)
R. Sanchez-Porras, O. Sakowitz (Heidelberg)
10:45 - 11:10
Coffee
11:10 - 12:30
COSBID: Cortical SDs Perspective
11:10 - 11:30
Basic requirements for data collection and trial design
A.J. Strong (London)
11:30 - 11:50
Potential treatment options: Ready for primetime?
11:50 - 12:10
Cortical SDs and temperature modulation: Is there a role for
therapeutic hypothermia?
12:10 - 12:30
Cortical SDs : Will it change the management of our patients
with acute brain injury?
G. Broessner (Innsbruck)
C. Thomé (Innsbruck)
Discussion and Closing Remarks
12:30 - 13:00
COSBID Steering committee
Notes
Map
Map
Lecture hall (Seminarraum 1 X , MZA (= Medizin Zentrum Anichstrasse)
Universitätskliniken, LKH Innsbruck
Anichstrasse 35, A-6020 Innsbruck
1
Entrance Anichstrasse
X
1
Map
Map – Restaurant Glasmalerei
X
Restaurant Glasmalerei
Glasmalereistrasse 5, A-6020 Innsbruck
1
Lecture hall
MZA (= Medizin Zentrum Anichstrasse)
1
X

Medizinische Universität Innsbruck

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