Annual Scientific Report - Centro de Química da Madeira

2010
Annual Scientific Report
Funchal, December 2010
THE RESEARCH UNIT IS FINANCIALLY SUPPORTED BY THE
FCT Research Unit Number: 674
(CHEM-Madeira-Funchal-674)
CONTACT D ETAILS
Centro de Química da Madeira
Universidade da Madeira
Campus da Penteada
Funchal, 9020-105
Portugal
Tel: +351 291 705150
Fax: + 351 291 705149/249
E-mail: [email protected]
Website: http://cqm.uma.pt
Twitter: http://twitter.com/UMa_CQM
Facebook: http://on.fb.me/gqSeD9
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RELATÓRIO CIENTÍFICO 2010 – UI674
A presente aplicação permite o preenchimento do Relatório Científico da sua Unidade
de I&D ou Laboratório Associado (LA) relativo ao ano de 2010. O formulário deverá ser
preenchido exclusivamente em inglês embora não seja necessário traduzir os títulos de
trabalhos publicados noutras línguas.
Relatório Científico 2010 - Objectives and Achievements
This part of the report will allow you to describe the way in which the Unit or the LA is
organized and managed, to give the general objectives of the research within the Unit
or the LA and finally to give a brief description of the main achievements of the
research carried out as a whole during the 2010 period. A maximum number of
characters (without spaces) are allowed in each field. If the number of characters
exceeds the maximum you will not be able to complete the form and an error message
will appear when you try to save your work
1. Unit Description (3000 ca.)Here indicate the form of organization and management.
Descrever a forma como o Laboratório/Unidade está organizado e como é feita a sua gestão
interna
CQM is a research unit located in the Univ. of Madeira (UMa), Madeira Island. After
the internal re-organization of UMa in 2009, the CQM was formally integrated in the
Competence Centre of Exact Sciences and Engineering (CCESE), a new university
structure that aggregated the previous Dep. of Chemistry, Mathematics and
Engineering and Physics. However, its scientific and strategic autonomy was
maintained and new synergies are under development in the framework of CCESE. As a
result of this merging, joint Research Projects involving researchers of the CQM and
the CCESE are ongoing since 2009.
At the end of 2010, the CQM’s team was composed by: 12 permanent PhD members (8
from the CCESE and the Centre of Life Sciences, 2 from R&D governmental labs, 1
contracted in the scope of Ciência 2008, and 1 sponsored by the Santander Totta Bank
(Invited Research Chair in Nanotechnologies)), one Technician with a PhD, 6 post-docs
fellows and 24 registered co-workers (1 PhD, 10 PhD Students, 10 MD Students and 4
other graduate researchers).
The centre is organized in 2 research groups -Natural Products and Materials-, each led
by a senior PhD member (group director/principal investigator) from the permanent
staff.
The research unit is managed by:
a) The scientific coordinator;
b) The scientific committee (SC);
c) The executive committee (EC).
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The scientific coordinator is a PhD member who is from the permanent staff and is
responsible for representing the Unit in all R&D aspects. The scientific coordinator is
elected by the SC for a period of 2 years. The next election for scientific coordinator
will occur on January 2011. The SC (composed by all PhD members belonging to the
permanent staff) establishes the main rules and guidelines for the CQM management,
along with the scientific strategy for the Unit. The EC is formed by the scientific
coordinator and two other PhD members (usually, the 2 group directors), having the
role of implementing the decisions of the SC.
The management of CQM considers the opinion of an External Scientific Advisory
Board (ESAB) consisting of: Martinho Simões, Head of ITQB, Portugal; Maria Bellantone,
Senior Editor of Springer; and Xiangyang Shi from Donghua University, Shanghai,
People’s Republic of China (until the end of 2010 since, meanwhile, he was contracted
by UMa). The recommendations of the international evaluation panel that evaluates
the Unit each four years (under the scope of the FCT) is also taken into account.
The CQM members can be assigned for the coordination of special activities/projects
to facilitate their performance (such as post-graduate courses, outreach science
actions, etc.). The maintenance and management of important equipments, such as
the 400MHz NMR and LCMSMS equipments, as well as safety and lab space
management, are also undertaken by specific CQM members.
The CQM also benefits from the work of two administrative staff members (in part
time) belonging to UMa for the financial management of R&D projects (FCT Base
funding/pluriannual budget included).
The Base funding from the FCT (our main sponsor) varies annually, depending on the
number of PhD members and on the classification attributed by the international
evaluation panel (Good in the last evaluation – 2008). This value was €41 250 in 2010.
The CQM’s financial strategy is to primarily prioritize the common interests of the
whole Unit (NMR and LCMSMS equipments, as well as common consumables, like
gases and cryogenic liquids, commonly used equipment, minor repairs, etc.), and if
possible, to invest in the acquisition of new equipments. The remaining budget is
distributed among the permanent PhD members, according to their requirements. In
2010, roughly 54% of our annual budget was spent in common expenses.
2. General Objectives (3000 ca.)This refers to the current aims of the Unit or LA as a whole.
Apresentar os objectivos gerais relativos ao Laboratório/Unidade como um todo
The CQM’s main objective is to establish a research unit in Madeira Island with
national and international recognition, so as to enliven the R&D activities in Chemistry,
Biochemistry and related scientific areas throughout the Madeira archipelago, as well
as to contribute for the raise of the national scientific production in terms of number
and impact factor.
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Furthermore, it is our aim to contribute for the post-graduate formation at the
University of Madeira, as well as for the promotion of the scientific culture among the
general population, in particularly the young generation.
In order to achieve these general objectives, our efforts are directed to:
a) Focusing on the R&D activities, considering the academic staff member’s field of
expertise, the geographical location of the unit, as well as the strategic areas defined
for the near future by the University of Madeira (its development plan for 2010-2013),
the National and the Regional Government (nanotechnology and health sciences), as
well as the general priorities of the European scientific policy in terms of R&D activities
and technology transfer;
b) Strengthening the two research groups by increasing the number of PhD members,
PhD students and Master students. We have a permanently open call in our web site
for outstanding candidates to become PhD students and post-doc researchers at CQM;
this has been also announced in international websites (such as Nature Jobs and the
European Commission EURAXESS Jobs Portal). Indeed, over the past few years, we
have submitted a large number of applications to the FCT program for “Advanced
Formation and Qualification of Human Resources”;
c) Reinforcing the centre with necessary/crucial equipment not yet available at our
University, either through research projects funding or through national programs
dedicated to equipment acquisition;
d) Establishing new national and international collaborations, while empowering the
existing ones, with institutions able to support and complement our research;
e) Promoting at national and international level the ongoing research at CQM;
f) Searching for funds by submitting project proposals at the national and international
level along with other national and international partners;
g) Reinforcing the interactions between both research groups at CQM by launching
more collaborative research projects;
h) Increasing and improving the number and quality of publications (Impact Factor), an
objective that will certainly be fulfilled in the following years as a result of the previous
described strategy;
i) Participating in the post-graduate courses currently offered by UMa (namely, the
Master program in “Applied Biochemistry”) and launching new educational offers in
the domain of nanochemistry and nanomaterials;
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j) Keeping active the ongoing projects related with the dissemination of chemistry and
biochemistry and be involved in the activities of the International Year of Chemistry
that will be commemorated in 2011.
3. Main Achievements during the year of 2010 (3269 ca.)Highlights from past research over
the reported period. Apresentar os principais objectivos atingidos durante o ano a que
respeita o Relatório, tendo por base as principais linhas de investigação em destaque
2010 was positively marked by the reinforcement of the CQM in terms of research
team, equipments and by the increasing of the average impact factor (IF) of our
publications by 20% (from 3 to 3.6).
Currently, the CQM staff comprises 3 more PhDs (the recipient of the Invited Chair in
the field of Nanotechnology, a post-doc fellow and the PhD technician for the LCMSMS equipment), one more PhD student and 8 more Master Students than in 2009.
In 2010, 1 PhD left the center and, unfortunately, the first CQM administrative staff
member (a key person in the internal re-organization of CQM made in 2006-2007, Dr.
Ana Fráguas) passed away with the age of 47 years. 5 Master students concluded their
theses in this period.
According to our strategy of reinforcement of necessary/crucial equipment to serve
both CQM research groups, we acquired, in 2010 (a total investment of 202.2 K€), the
following equipments:
a) A Water purification system from Millipore (Pluriannual base funding. Cost: 8.3
K€);
b) A ACQUITY UPLC H-Class from Waters (Research proj. INTERREG-IIIB-MAC
2009-2012. Cost: 60 K€);
c) A Biological safety cabinet from Labgard (Research proj. INTERREG-IIIB-MAC
2009-2012. Cost: 7 K€);
d) An Ultra-freezer UF550-86E from Snejder (-80 ºC) (Research proj. INTERREGIIIB-MAC 2009-2012. Cost: 7 K€);
e) A Solvent purification system from MBRAUN (Research proj.
PTDC/CTM/098451/2008. Cost: 34.9 K€);
f) A zetasizer, a q-Nano(the first equipment to be installed in Portugal) and a
electrospinning apparatus, to be installed in 2011 (Supported by the University
of Madeira under the scope of the Invited Chair in Nanotechnology Cost: 85 K€).
The ongoing research projects carried out by the CQM researches represent around
€2.2 millions. This amount, along with previous financed projects funded by different
entities (e.g. FCT, INTERREG IIIB), sum more than €4.1 millions (until 2014).
Facts and Figures for 2007-2010 (December) period:
Number of PhDs: 2007 (15); 2008 (15); 2009 (18); 2010 (19);
Number of PhD students: 2007 (8); 2008 (9); 2009 (9); 2010; (10);
Number of publications in 2010: 30 (15 papers with IF, one book chapter, 5 MS theses,
and 9 other publications);
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2007-2010 period publications with IF (56): 2007 (14); 2008 (12); 2009 (15); 2010(15);
Average IF: 2007 (2.8); 2008 (3.0); 2009 (3.0); 2010 (3.6).
Productivity:
1) Papers in peer review journals with IF: 15 (plus 24 accepted or submitted). The
complete list of publications is available at http://cqm.uma.pt/publicacoes).
Internationalization (47%): 7 in 15 papers were published in co-authorship with
other international teams.
2) Book chapters:1
3) Papers in peer review journals without IF:1
4) Conference proceedings: 1
5) Technical and Scientific reports: 6
6) Oral communications: 24 (5 in international conf., including 2 invited oral
communications)
7) Posters: 26 (13 in international conf.)
8) Graduations: PhD Theses: 0; Master Theses: 5
9) Popular press articles and newspaper interviews: 4
10) Science divulgation communications: 1
11) Number of international conf. and advanced schools co-organized by CQM
team members: 0
12) Number of national conf. or advanced schools co-organized by CQM team
members: 1
13) Number of visiting fellows: 5 (Geoffrey Ozin (Canada), José Rivas
(Portugal/Spain), Matthias Epple (Germany), Manuela Pereira and Margarida
Bastos (Portugal))
14) Advanced training: 10 PhD Sts; 10 MSts
15) Networking:
The CQM is a full member of the following Portuguese networks: National Nuclear
Magnetic Resonance Network (PTNMR; http://ptnmr.dq.ua.pt), National Mass
Spectrometry Network (RNEM; http://rnem.fc.ul.pt/) and Nanotechnology
(PortugalNano; http://www.portugalnano.org), all supported by FCT. At international
level, CQM also integrates the COST Action TD0802 (Dendrimers in Biomedical
Applications , the Netbiomed network and CYTED RED IBEROAMERICANA.
Relatório Científico 2010 - Activities
This part of the report will allow you to describe general activities of the Unit or the LA
that are aimed at integrating the research of various groups of which multidisciplinary
and/or trans-disciplinary activities are of particular relevance. The second part is aimed
to describe work that the Unit or the LA does to extend beyond the scientific
environment and to reach the general public, schools or other forms of engaging the
public in the work of the Unit or the LA.
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1. Integrative/multidisciplinary activities during the year of 2010 (3000 ca.)Special
activities that aim to carry out research across disciplines. Apresentar as actividades
realizadas nas quais ocorreu interdisciplinaridade entre as diversas sub-áreas científicas que
decorreram durante o ano a que respeita o Relatório
As a relatively small unit, the contact between both research groups is easy, promoted
and fundamental for the growth and consolidation of our research centre. This is the
reason why the CQM members from the Materials Group and Natural Products Group
have been working together in:
a) The preparation of joint research proposals; in 2010, one project was submitted to
the FP 7 with the participation of researchers from both groups:
1) “ChemMad-Strengthening the Chemistry Research Potential in Madeira
Island”, FP7-REGPOT-2011-1 Funding requested to FP7: € 2 184 549 (under evaluation).
b) Science popularization activities (e.g. “Ocupação Científica de Jovens nas Férias”, 1
week in July, and “A Química é Divertida/Chemistry is Fun”, 1 week in November). All
senior and junior members of the CQM are engaged in these events.
c) The projects connected with the participation of CQM in the National NMR and
Mass Spectrometry networks. These projects were extended, in 2008/2009, for more
three years, based in a joint proposal submitted to FCT (REDE/1508/REM/2005: €71
320, until 2012 and REDE/1517/RMN/2005: €116 454, until 2013). In the scope of the
National Mass Spectrometry network, a Ph D technician was hired by CQM to support
the LCMSMS equipment and help both research groups.
d) The management/sharing/maintenance of the equipments and Lab spaces.
e) The preparation of the Nanoschool 2010 (this year the lessons were given by Prof.
Matthias Epple from the Inorganic Chemistry and Center for Nanointegration of the
University of Duisburg-Essen, Germany) which covered 1 week period and was
integrated in the Master course “Applied Biochemistry”.
f) The supervision of periods of laboratory training for the students of the 1st cycle in
Biochemistry offered by UMa; these periods of training (called “Estágios de Verão no
CQM”) occurred in July 2010; 9 students were enrolled in this training period.
2. Outreach activities during the year of 2010 (3000 ca.)Science and Society/general
public/schools, etc. Apresentar as actividades científicas com alcance exterior ao
Laboratório/Unidade a nível da sociedade, das escolas e do público em geral, realizadas
durante o ano a que respeita o Relatório
The current activities of CQM also include several initiatives that have the objective of
promoting the awareness of science among youngsters.
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As in the previous years, the outreach activities of CQM during 2010 were based in two
main projects: “A Química é Divertida/Chemistry is Fun” (several
chemistry/biochemistry
related
activities
performed
during
1
weekhttp://cqm.uma.pt/quimicadivertida) and “Ocupação Científica de Jovens nas Férias”
(for high school student participation in research activities, during one week). The
second activity was funded by Agência Nacional para a Cultura Científica e Tecnológica
(ANCCT) - Ciência Viva (€ 1662). In these two projects involved, respectively, 350 and
12 high school students.
Additionally, CQM developed a research training program called “Estágios de Verão no
CQM” which started in 2008 and is mainly directed to the students of the 1st cycle in
Biochemistry offered by UMa. This program involves the participation of the two
research group members of the CQM and is entirely supported by the FCT base
funding. During 1 month (July), about 10 students are embedded in the research
projects of both research groups. The students have the chance to get acquainted with
the routine of lab research, learn new techniques, gain news skills and develop new
attitudes to overcome common and advanced research problems. In addition, the
students have the possibility to know more about the research performed at CQM.
Another way to show our different activities and discover new potential candidates to
the field of science, namely chemistry and biochemistry, is through guided visits of
high schools. During the year of 2010 and out of the “Chemistry is Fun” period, our
research Labs received the visit of more than 100 high schools students.
Along the year, several conferences (open to the general public) were presented by
special guests invited by CQM.
One of our privileged way to contact and spread our activities is through the CQM´s
website (http://cqm.uma.pt), produced in English and Portuguese - with 80
accesses/day in 2010, 13 % less than in 2009 (29 045 accesses /year in 2010 vs. 32 789
accesses/year 2009), 3.87 pages/visitant and 25.94 hits/visitant and 18.4 GB data
transfer(ca. 122% more than in 2009) – and through the social networking service
Twitter (http://twitter.com/UMa_CQM) (in December 2010, we were followed by 170
persons or organizations, mainly from the academia, more 41% that in 2009).
Furthermore we have a regular service of press release, a CQM flyer and a Facts and
Figures report (continuously up-dated) to be distributed during the events organized
by CQM.
CQM also often makes the news in the regional and national media. In 2010, ca. 35
short news in newspapers and in specialized scientific websites were published,
including two special reports (one in the weekly national newspaper “”Sol” and the
other in the scientific news website “http://www.cienciahoje.pt) and 3 big interviews
(one on the newspaper “Jornal da Madeira” and the others in the website
“http://aeuropanasnossasmaos.wordpress.com/”). The regional TV channel usually
covers all our activities (Scientific Meetings/conferences, Science Popularization
Actions, etc.). The CQM´s activities obtained, in 2010, a total estimated time of 6 min
in prime time news of our Regional TV station.
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Relatório Científico 2010 - Funding
In this section include funding details during the reporting period.
Composition and Training
In this section indicate the number of researchers hired through the Ciência Programme,
during the reporting period. Include also the total number of integrated Researchers with PhD
and the PhD thesis completed in the period.
(*) Number of eligible integrated researchers holding a doctoral degree.
Researchers Hired
In this section indicate the individual researchers hired in the period by introducing the
association key (previously named as public key), their starting date and if applicable their
finishing date. In case the researchers also hold a part-time position at another institution
(teaching at University or Polytechnic) also indicate this in Other Institution.
Warning: Dates must be in the dd-mm-aaaa format.
Technical Personnel Hired
In this section indicate individual technical personal hired. To do so all personal must be
registered
at
the
FCT
and
have
an
association
key.
Warning: Dates must be in the dd-mm-aaaa format.
Additional Comments:
In this space you can provide any additional information regarding the section General
Indicators
1. Additional Comments - Apresentar comentários adicionais relativos à secção “General
Indicators”
Despite the size of the research centre (considering not only the number of
researchers (only 19 PhDs)), the available time devoted to research by the permanent
staff (8 researcher only in full time) and the lack of essential techniques for materials
characterization (as stated by the evaluation panel in the 2008 report)), the results
presented in this report clearly show a positive trajectory and the success
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of the strategy taken by the R&D center. We are truly confident that we will obtain a
better classification in the next FCT evaluation exercise.
At the present moment, our main concerns are related with the following aspects:
a) The FCT was not able to fulfill the recommendations made by the panel of experts
who participated in the last evaluation exercise (2007/2008), in particular, the aspects
concerned with additional funds for traveling and for basic equipment for the Unit.
This omission from FCT, not only devalued the work of the evaluation panel, but also
restricted the natural development of the CQM (its capacity to attract people and be
more competitive).
b) The difficulties in contracting new post-docs and PhD Students - this is an important
issue, especially for us since we are located far away from the big institutions. Indeed,
the FCT Rules for Advanced Training and Qualification of Human Resources remain
very limited in terms of the recruitment of PhD students by not allowing proposals
from foreign students. In some domains/areas were vocations are decreasing (like
Chemistry), this limitation may result in a major drawback for the scientific
development, not only at our Research Centre, but also in all Portugal.
However and despite the difficulties expected for the coming years (e.g. economical
crisis), we remain strongly committed in improving the physical and human resources
at CQM and, as a consequence, in increasing our scientific output.
Relatório Científico 2010 - Research Groups
(RG-Madeira-674-390) Materials Group
In this section of the report you have the names of each Research Group and their
Principal Investigators that were indicated in the last report. By following the link in
the groups name you will be able to access the individual form of the group.
This list includes the currently active Research Groups as well as the Research Groups
reported to be active in the previous year.
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
Group Description
Group Description:
Please indicate mains sources of funding for the research of your group. Include all
types of funding, like FCT projects, FCT Base, as well as funding from other institutions.
You should indicate an approximate amount in EUROS, and the source to which the
funds apply.




Research Group Title: (RG-Madeira-674-390) - Materials Group
Principal Investigator: Helena Maria Pires Gaspar Tomás
Research Area: Chemistry
Home Institution: Universidade da Madeira
1. Funding, source, dates (1000 ca.) - Apresentar os financiamentos alocados
especificamente ao Grupo em questão e as respectivas fontes:
Ongoing projects and grants (Total funds allocated to the group in the period 20062014: € 859.755):
PI: Principal Investigator
INTERREG IIIB funded:
€780.000 (€100.000 for CQM): BIOPHARMAC-MAC/1/M104. 2009-2012; PI: Miguel
Xavier
FCT funded
€157.193 (€4.730 for CQM): PTDC/QUI-QUI/099815/2008. 2010-2012; PI : Miguel
Xavier
Headed by Materials Group:
€175.000 (€129.325 for CQM): PTDC/SAU-BEB/71161/2006. 2007-2010; PI: Helena
Tomás
€101.200 (€101.200 for CQM): PTDC/QUI/64202/2006. 2008-2011; PI: João Rodrigues
€168.100 (€168.100 for CQM): PTDC/CTM/098451/2008. 2010-2013; PI: João
Rodrigues
€ 47.040 x 3: PhD grant SFRH/BD/265036/2009. 2010-2014 (Manuel Jardim) ;
SFRH/BD/24547/2005. 2006-2010 (Carla Alves) ; SFRH/BD/29325/2006. 2007-2011
(João Figueira)
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€ 53.820 x 4: Post-Doc grants SFRH/BPD/30954/2006. 2007-2011 (Viney Lather);
SFRH/BPD/41787/2007. 2008-2011 (Visvaldas Kairys); SFRH/BPD/44821/2008. 20092012 (Deepti Pandita); SFRH/BPD/47369/2008: 2009-2012 (Alireza Nouri)
Projects and grants to be started in 2011 (approved in 2010):
€151.251 (€80.193 for CQM): FCT funded. PTDC/CTM-NAN/112428/2009. 2011-2014.
PI Helena Tomás
€ 53.820: 1 Post-Doc grant SFRH/BPD/75420/2010: 2011-2013 (Shili Xiao)
Objectives and Achievements:
This section allows you to provide the objectives and achievements during the reporting period.
1. Objectives (4000 ca.) - Apresentar os objectivos específicos do Grupo
For 2010 and the coming years, our group established as main objective to focus
research in the field of new materials (in particular, molecular and nanomaterials) that
are designed and produced with specific applications in mind, namely in the areas of
biomedicine and optoelectronics. Taking advantage of a team of researchers with
complementary expertise and concurrent interests (able to connect theory,
computation, and experiment in a cohesive way), the idea is to launch projects
addressing outstanding scientific questions and technological issues,
with clear
objectives, and an applied focus. In this scope, the objectives include the conception
of new materials, processes and software related to the applications envisaged, as well
as the understanding of the chemical foundations of those materials and processes.
The group aims to critically question results and propose innovative ways to solve
problems, to perform the highest quality research in an ethically responsible manner,
to communicate findings to laypeople and experts and to promote the transfer of
knowledge and technology.
In relation to the mentioned scientific objectives, the group established for 2010 and
subsequent years the following measurable goals:

To enhance the scientific output of the team, i.e., the number of publications (in
international peer review journals) and their impact factor;
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
To increase the number of researchers (namely, Post-Doc, Master and PhD
students);

To obtain more funding (from national and European sources), especially to
acquire scientific equipment needed for the characterization of materials, in
particular of nanomaterials;

To strengthen the internationalization of the team by launching new collaborative
projects with institutions and universities abroad, by organizing/co-organizing
scientific meetings, workshops and schools and by integration of the team in
international scientific networks.
2. Main Achievements (4000 ca.) - Apresentar os principais objectivos atingidos relativamente
ao Grupo
In 2010, the group consisted of 13 PhDs (8 members from the host institution, and 5
post-doc researchers), 3 PhD students, 5 Master Students and 1 researcher already
holding a Master degree. One Brazilian Master student (Thiago Fidéles) also worked
during 4 months at CQM in the scope of a collaborative work (shared master work
supervision).
In 2010, the main achievements of the Materials Group can be resumed as following:
a) The group published 7 papers in peer review journals (4 of them with an impact
factor higher than 5.3); 9 other papers were accepted for publication (7 with an
impact factor higher than 4.5) and more 6 were submitted during 2010; 1
international proceeding and 1 book chapter with peer review were also
published in 2010;
b) The group presented a total of 18 oral presentations in scientific meetings (4 in
international meetings) and 9 posters presentations (2 in international
meetings);
c) In 2010, the Materials group staff was reinforced with a top level researcher in
the Nanochemistry and Nanomaterials field (Xiangyang Shi, Ph.D., Chair in
Nanotechnology) through the support of the University of Madeira (UMa), FCT
and a private bank (Santander Bank);
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d) At the end of 2010, three new equipments were acquired (with University of
Madeira funds) to reinforce the area of nanomaterials characterization namely,
a Zetasizer (for size and zeta potential determination of nanoparticles) and a
qNANO (for size determination of nanoparticles) and an Electrospinning. These
equipments will be installed during 2011.
e) Neide Freitas, Freddy Rodrigues and Thiago Fidéles concluded their Master
degree and more three Master works started (Rita Castro, Daniel Lima and
Mara Gonçalves);
f) Two
new
FCT
funded
research
projects
started
in
2010
(PTDC/CTM/098451/2008 and PTDC/QUI-QUI/099815/2008), as well as a PhD
grant (SFRH/BD/265036/2009, Manuel Jardim);
g) Through Helena Tomás, the Materials Group integrated the COST Action
TD0802 – Dendrimers in Biomedical Applications since the beginning of 2010
(although, formally, in 07/02/2011);
h) New funds for research were obtained by the group correspondent to 1 FCT
funded research project ( PTDC/CTM-NAN/112428/2009, to be started in 2011)
and 1 Post-Doc Grant (SFRH/BPD/75420/2010, Shili Xiao, to be started in 2011);
i) In 29 January, the group organized the 5th Materials Group Meeting at the
University of Madeira (open to all academia/number of participants: 30);
j) In the scope of the project BIOPHARMAC, the group organized 1 workshop and
1 practical course (20-22 October 2010, Funchal) open to people outside the
project;
k) In October, the group also organized the NanoSchool 2010 which had the
participation of Prof. Matthias Epple (from the University of Duisburg-Essen,
Germany) as a lecturer (the school had around 50 participants);
Distinctions, Awards and Merits

Miguel Xavier Fernandes (the former principal investigator of the Materials
Group) is, since the middle of 2009, Vice-Rector of the University of Madeira.

Pedro Pires was appointed as National Expert assigned to the Unit of Micro and
Nanosystems of the DG Information Society (INFSO G2) European Commission,
and is in Brussels since 2006.
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
Helena Tomás was member of the Scientific Committee of the 5th International
Meeting of the Portuguese Society for Stem Cells and Cellular Therapy;
Guimarães, Portugal; 20-21 May, 2010.

João Rodrigues was appointed Member of the National Committee for the
celebration of the International Year of Chemistry 2011; he was member of the
Scientific Committee of the XVI Meeting of the Portuguese Electrochemistry
Society (also XII Iberian Meeting of Electrochemistry); he belongs, since 2008,
to the National Technical Advisory Team of the 7 Framework Program (FP7) –
Cooperation Theme 4: Nanosciences, Nanotechnologies, Materials, and New
Production Technologies (NMP) from Gabinete de Promoção do 7º ProgramaQuadro de I&DT. He is also member, since 2008, of the evaluation panel of
COST Action D35 - Molecular Devices (Switzerland Multilateral ResearchCooperation, Swiss Confederation) and member of the evaluation panel of
Information and Communication Technologies (ICT) of the 7th FP (Small and
medium scale focused research projects (STREPs)) since the same year (2008).
He is, since November 2009, member of the Scientific Board of the Centre of
Competence in Exact Sciences and Engineering.
Group Productivity: (Publications in peer review Journals, Other international publications,
Ph D Thesis completed, Patents and prototypes, Organization of Conferences, Industry
contract research, Internationalization, Government/Organization of contract research)
Publications in peer review Journals (6000. ) - Referir os principais artigos de publicações com
factor de impacto definido, de membros integrados do Grupo:
PUBLISHED ARTICLES IN PEER REVIEW JOURNALS(IF 2009)
10.1.
Alves C. S.; Melo M. N.; Franquelim H. G.; Ferre R.; Planas M.; Feliu L.; Bardají
E.; Kowalczyk W.; Andreu D., Santos N. C.; Fernandes M. X. and Castanho M.
A.; Escherichia coli cell surface perturbation and disruption induced by
antimicrobial peptides BP100 and pepR; J. Biol. Chem., 285: 27536 - 27544;
2010 (IF: 5.328).
15
10.2.
Jardim M.G.; Rissanen K. and Rodrigues J.; Preparation and Characterization of
Novel Poly(alkyliden imine) Nitrile Ruthenium Metallodendrimers; Eur. J. Inorg.
Chem., 11: 1729 - 1735; 2010; doi: 10.1002/ejic.200901187 (IF: 2.941).
10.3.
Li Y. and Yang G.; An unusual morphology and crystallization behavior in insitu formed polyphenylene oxide/polyamide 6 blends; J. Mater. Sci., 45: 987992; 2010 (IF: 1.471).
10.4.
Nalam, M. N. L.; Ali, A.; Altman, M. D.; Reddy, G. S. K. K.; Chellappan, S.; Kairys,
V.; Özen, A.; Cao, H.; Gilson, M. K.; Tidor, B.; Rana T. M. and Schiffer C. A.;
Evaluating the Substrate‐envelope hypothesis: Structural analysis of novel
HIV‐1 Protease inhibitors designed to be robust against drug resistance; J.
Virol., 65: 5368‐5378; 2010; doi:10.1128/JVI.02531-09 (IF: 5.150).
10.5.
Palmeira A.; Paiva A.; Sousa E.; Seca H.; Almeida G. M.; Lima R. T.; Fernandes
M.X. and Pinto M., Vasconcelos M. H.; Insights into the in vitro antitumor
mechanism of action of a new pyranoxanthone; Chem. Biol. Drug Des., 76: 4358; 2010 (IF: 2.473).
10.6.
Santos J. L.; Oliveira H.; Pandita D.; Rodrigues J.; Pêgo A. P.; Granja P. L. and
Tomás
H.;
Functionalization
of
Poly(amidoamine)
Dendrimers
with
hydrophobic chains for improved gene delivery in mesenchymal stem cells; J.
Control. Rel., 144: 55 - 64; 2010; doi: 10.1016/j.jconrel.2010.01.034 (IF: 5.949).
10.7.
Santos J. L.; Pandita D.; Rodrigues J.; Pêgo A. P.; Granja; P. L., Balian G. and
Tomás H.; Receptor-mediated gene delivery using PAMAM dendrimers
conjugated with peptides recognized by mesenchymal stem cells; Mol.
Pharmaceutics, 7: 763 - 774; 2010; doi: 10.1021/mp9002877 (IF: 5.408).
BOOK CHAPTERS
Palmeira A., Rodrigues F., Sousa E., Pinto M., Vasconcelos M.H., Fernandes M.X.;
Pharmacophore-Based Screening as a Clue for the Discovery of New P-Glycoprotein
Inhibitors, pp. 175 – 180, in "Advances in Bioinformatics: Advances in Soft Computing",
Rocha MP et al. Eds. Springer Berlin/Heidelberg; 2010, ISBN: 978-3-642-13213-1.
PROCEEDINGS WITH PEER REVIEW
16
Li Y.; Santos J.L.; Maciel D.; Tomás H.; Rodrigues J.; Injectable hybrid Laponite/alginate
hydrogels for sustained release of methylene blue; The Symposium on Innovative
Polymers for Controlled Delivery (SIPCD); Suzhou, China; September 14-17; pages 169171, 2010.
ACCEPTED PAPERS IN PEER REVIEW JOURNALS
AP10. 1. Bonniard L., Kahlal S., Diallo A., Ornelas C., Roisnel T., Manca G., Rodrigues J.,
Astruc D.; Saillard, J.-Y.; How Do Nitriles Compare with Isoelectronic Alkynyl
Groups in the Electronic Communication between Iron Centers Bridged by
Phenylene-Bis- and Tris-Nitrile Ligands? An Electronic and Crystal-structure
Study; Inorg. Chem., 50: 114–124; 2011 (IF: 4.570).
AP10. 2. Fang, X.; Ma, H.; Xiao, S.; Shen, M.; Guo, R.; Cao, X.; Shi, X. Facile
Immobilization
of
Gold
Nanoparticles
into
Electrospun
Polyethyleneimine/Polyvinyl Alcohol Nanofibers for Catalytic Applications. J.
Mater. Chem. 2011, In press (J. Mater. Chem., DOI: 10.1039/C0JM03987J) (IF
4.795).
AP10. 3. Guo, R.; Wang, H.; Peng, C.; Shen, M.; Zhang, G.; Shi, X. Enhanced X-Ray
Attenuation
Property
of
Dendrimer-Entrapped
Gold
Nanoparticles
Complexed with Diatrizoic Acid. J. Mater. Chem. 2011, In press (J. Mater.
Chem., doi:10.1039/C0JM04094K) (IF: 4.795).
AP10. 4. Nouri A., Hodgson P.D., Wen C.E., Effect of ball-milling time on the structural
characteristics of biomedical porous Ti–Sn–Nb alloy; Materials Science and
Engineering: C, 2011, 41, 1409-1420; doi:10.1016/j.msec.2011.02.011(IF:
1.842).
AP10. 5. Palmeira A., Rodrigues F., Sousa E., Pinto M., Vasconcelos M. H., Fernandes
M. X., Pharmacophore‐based screening for the discovery of novel oxapine
based P‐glycoprotein inhibitors; Chem Biol Drug Des (IF: 2.375).
AP10. 6. Pandita D., Santos J.L., Rodrigues J., Pêgo A. P., Granja P., Tomás H.; Gene
delivery into MSCs: a biomimetic approach using RGD nanoclusters based on
poly(amidoamine) dendrimers; Biomacromolecules, 12: 724–481; 2011;
http://dx.doi.org/10.1021/bm1012647 (IF: 4.502).
17
AP10. 7. Santos, J.L., Pandita, D., Rodrigues, J., Pêgo, A.P., Granja, P.L., Tomás, H.;
Non-viral Gene Delivery to Mesenchymal Stem Cells: Methods, Strategies
and Application in Bone Tissue Engineering and Regeneration; Curr. Gene
Ther., 11: 46–57; 2011; http://dx.doi.org/10.2174 (IF: 4.85).
AP10. 8. Wang, H.; Zheng, L. F.; Peng, C.; Guo, R.; Shen, M.; Shi, X.; Zhang, G.
Computed Tomography Imaging of Cancer Cells Using Acetylated DendrimerEntrapped Gold Nanoparticles; Biomaterials, 2011, in press (IF: 7.365).
AP10. 9. Wang, Y.; Guo, R.; Cao, X.; Shen, M.; Shi, X. Encapsulation of 2methoxyestradiol within multifunctional poly(amidoamine) dendrimers for
targeted cancer therapy; Biomaterials, 2011, in press (IF: 7.365).
SUBMITTED PAPERS TO PEER REVIEW JOURNALS
SP10.1.
Li Y.; Tomás H.; Rodrigues J.; Injectable and Biodegradable Hydrogels as 3-D
Bioreactors:
Gelation,
Biodegradation
and
Biomedical
Applications
(submitted).
SP10.2.
Cao, X.; Chen, J.; Wen, S.; Peng, C.; Shen, M.; Shi, X. Effect of Surface Charge
of Polyethyleneimine-Modified Multiwalled Carbon Nanotubes on the
Improvement of Polymerase Chain Reaction (submitted).
SP10.3.
Xiao, S.; Ma, H.; Shen, M.; Wang, S.; Huang, Q.; Shi, X. Excellent copper (II)
removal using zero-valent iron nanoparticle-immobilized hybrid electrospun
polymer nanofibrous mats (submitted).
SP10.4.
Liao, H.; Shen, M.; Qi, R.; Cao, X.; Guo, R.; Zhang, Y.; Shi, X. Improved Cellular
Response on Multiwalled Carbon Nanotube-Incorporated Electrospun
Polyvinyl Alcohol/Chitosan Nanofibrous Scaffolds (submitted).
SP10.5.
Xiao, S.; Shen, M.; Ma, H.; Fang, X.; Huang, Q.; Weber, W. J., Jr., Shi, X.
Manipulation of the loading and size of zero-valent iron nanoparticles
immobilized in electrospun polymer nanofibers (submitted).
SP10.6.
Qi, R.; Shen, M.; Cao, X.; Guo, R.; Yu, J.; Shi, X. Exploring the dark side of MTT
viability assay of cells cultured onto electrospun polymer-based composite
nanofibrous scaffolding materials (submitted).
THESIS
18
TH10.1. Freitas N.M.F.C., Encapsulation of Single hMSCs in Polyelectrolyte Shells:
Preliminary Studies, thesis presented to obtain the MSc degree,
Universidade da Madeira, 92pp, 2010.
TH10.2. Rodrigues F., Avaliação de compostos com actividade inibidora da
glicoproteina-P, thesis presented to obtain the MSc degree, Universidade da
Madeira, 2010.
TH10.3. Fidéles TB, Filmes reticulados de quitosana para aplicação com biomaterial,
thesis presented to obtain the MSc degree, Universidade Federal de
Campina Grande (Brazil), 72pp, 2010.
ABSTRACTS IN INTERNATIONAL SCIENTIFIC MEETINGS
ORAL COMMUNICATIONS
OCI10.1. Fidéles T. B., Santos J. L., Fook A.C.B.M., Tomás H., Fook M.V.L.;
Physicochemical and biocompatibility evaluation of ionic crosslinked
chitosan films, 6th Latin American Congress of Artificial Organs and
Biomaterials, Gramado, Brazil, 2010.
OCI10.2. Figueira J.; Mesquita J.; Rodrigues J.; Rissanen K.; Preparation and
characterization of Ruthenium and Palladium dinuclear Rods as potential
molecular wires; 7th Supraphone Meeting, Bonn, Germany; April 28th – May
01st , 2010.
OCI10.3. Santos J. L.; Oliveira H., Pandita D.; Rodrigues J.; Pêgo A. P., Granja P. L.,
Tomás H.; Dendrimer surface tailoring for improved interactions with
mesenchymal stem cells; 2nd International Symposium on Biological
Applications of Dendrimers; Porquerolles Island (French Riviera), France; 2326 June, 2010.
OCI10.4. Santos J. L.; Pandita D.; Rodrigues J.; Pêgo A. P., Granja P. L., Tomás H.;
Improving biological interactions of PAMAM Dendrimers with mesenchymal
stem cells through surface functionalization; 7th Supraphone Meeting , Bonn,
Germany; April 28th May 1st; 2010.
POSTER COMMUNICATIONS
19
PCI10.1. Jardim M.G.; Rodrigues J.; Mesquita J.C.; Rissanen K.; Campo J.; Wenseleers
W.; Ruthenium-Iron Dendrimers Based on 2,4,6-Tri-Substituted-1,3,5Triazine core Derivates, 2nd International Symposium on Biological
Aplications of Dendrimers, Porquerolles Island, France; 23-26 June, Page P20,
2010.
PCI10.2. Li Y., Santos J.L., Maciel D., Tomás H., Rodrigues J.; Injectable hybrid
Laponite/alginate hydrogels for sustained release of methylene blue; The
Symposium on Innovative Polymers for Controlled Delivery (SIPCD); Suzhou,
China; September 14-17; pages 169-171, 2010.
ABSTRACTS IN NATIONAL SCIENTIFIC MEETINGS
ORAL COMMUNICATIONS
OCN10.1. Alves C.S., Kairys V., Fernandes, M.X.; Conformational and dynamic
properties of the cell‐penetrating peptide, Pep‐1, in model membrane
systems: Brownian dynamics simulations on a coarse‐grained model;
Biopharmac, Expert Training Course: Computational approaches applied to
drug discovery and development; Funchal, Portugal; 20‐22 October, 2010.
OCN10.2. Alves C.S., Melo M.N., Franquelim H.G., Ferre R., Planas M., Feliu L., Bardají
E., Kowalczyk W., Andreu D., Santos N.C., Fernandes M.X.; Castanho
M.A.R.B.; Relation between Escherichia coli killing and charge neutralization
by the antimicrobial peptides BP100 and pepR; EPI XII Encontro Peptídico
Ibérico / Iberian Peptide Meeting; Lisbon, Portugal; 10‐12 February, page 49,
2010.
OCN10.3. Fernandes S.M.A.; Mesquita J.C. and Teixeira J.M.G.; Ascorbic Acid
Determination at a 3-Mercapto-1-propanesulfonic Acid Sodium Salt SelfAssembled / Conducting Polymer Carbon Modified electrode; 5th Materials
Line Meeting/CQM; Funchal-Madeira; 29 January, 2010.
OCN10.4. Fidéles T. F.; Santos J. L.; Tomás H. and Fook M. V. L.; New ionic crosslink
chitosan films for biomedical applications; 5th Material Group Meeting/CQM,
University of Madeira, Funchal, Portugal, 29 January; OC4, 2010.
20
OCN10.5. Figueira J.; Mesquita J.; Rodrigues J. and Rissanen K.; Synthesis and
characterization of dinuclear Pd and Ru rods for the preparation of
organometallic molecular wires; 5th Material Group Meeting/CQM,
University of Madeira, Funchal, Portugal, 29 January, 2010.
OCN10.6. Figueira J.; Mesquita J.; Rodrigues J. and Rissanen K.; Ruthenium and
Palladium dinuclear OPE and OTE rods for nanoelectronic applications; 2nd
Portuguese Young Chemists Meeting, Aveiro, Portugal; 21st to the 23rd of
April, OC19, 2010.
OCN10.7. Freitas N.; Santos J. L.; Rodrigues J. and Tomás H.; Encapsulation of stem
cells using the Layer-by-Layer technique; 5th Material Group Meeting/CQM,
University of Madeira, Funchal, Portugal, 29 January; OC11, 2010.
OCN10.8. Jardim M.G.; Rodrigues J.; Mesquita J.C.; Rissanen K.; Wenseleers W. and
Campo J.; Novel Ru and Ru-Fe Dendrimers based on 2,4,6-tri-substituted1,3,5-triazine Core Derivatives; 5th Material Group Meeting/CQM, University
of Madeira, Funchal, Portugal, 29 January; OC6, 2010.
OCN10.9. Kairys V. and Fernandes M. X.; Toward the Design of Mutation‐Resistant
Enzyme Inhibitors: Further Evaluation of the Substrate Envelope Hypothesis;
Madeira Biopharmac Meeting; Funchal, Portugal; 20‐22 October, 2010.
OCN10.10.
Li Y.; Santos J. L.; Tomás H. and Rodrigues J.; Novel Laponite/Alginate
Hydrogels for Drug Release Applications; 5th Material Group Meeting/CQM,
University of Madeira, Funchal, Portugal, 29 January; OC10, 2010.
OCN10.11.
Rodrigues F. and Fernandes M.X.; Comparison of Machine Learning
Methods Using P‐glycoprotein Inhibitors. 5th Material Group Meeting/CQM,
University of Madeira, Funchal, Portugal, 29 January, 2010.
OCN10.12.
Rodrigues F. and Fernandes M.X.; Pharmacophore and Virtual Screening
Studies. BIOPHARMAC Workshop: Practical Course. Funchal, Madeira, 22
October, 2010.
OCN10.13.
Sousa I., Fernandes M. X.; Application of QSAR Studies to as Novel
Family of DNA TOP2 Inhibitors; 5th Material Group Meeting/CQM, University
of Madeira, Funchal, Portugal, 29 January, 2010.
OCN10.14.
Sousa I., Fernandes M. X.; Workshop BIOPHARMAC Practical Course –
QSAR Studies; Workshop BIOPHARMAC, Madeira, October 22th, 2010.
21
POSTER COMMUNICATIONS
PCN10.1. Araújo H.C., Barroso M., Pimenta A., Castro R., Rivera I. and Tavares de
Almeida I.; Polymorphisms in the transcobalamin II gene TCN2 776C>G and
TCN2 67A>G - evaluating hyperhomocysteinemia factors; SPDM VII
International Symposium; Algarve, Portugal; 4-5 Novembro, 2010.
PCN10.2. Figueira J.; Mesquita J.; Rissanen K. and Rodrigues J.; Synthesis and
electrochemical studies of molecular wires based on dinuclear Pd and Ru
OPE and OTE rods; XII Iberic Meeting of Electrochemistry & XVI Meeting of
the Portuguese Electrochemical Society, Lisbon; Portugal, 8-11 of September,
PE 12, 2010.
PCN10.3. Freitas N., Santos J.L., Rodrigues J. and Tomás H.; Encapsulation of single
Mesenchymal Stem Cells in polyelectrolyte shells – Preliminary results; 5th
International Meeting of the Portuguese Society for Stem Cells and Cellular
Therapy - Guimarães, Portugal; 2010.
PCN10.4. Lu Y.; Figueira J.; Jardim M. and Rodrigues J.; Analysis of Organometallic
Compounds by Using Electrospray Quadrupole Ion Trap Mass Spectrometry;
4th Portuguese Mass Spectroscopy Meeting, FCUL, Lisbon, Portugal; 13-15 of
December, P01 (p. 47), 2010.
PCN10.5. Lu Y.; Câmara J.S. and Rodrigues J.; Node activities (January 2010 –
December 2010) CQM/UMa (REDE/1508/REM/2005); 4th Portuguese Mass
Spectroscopy Meeting, FCUL, Lisbon, Portugal; 13-15 of December, P45 (p.
96), 2010 (Technical Poster presentation).
PCN10.6. Mesquita J.C.A., Fernandes S.M.A. and Teixeira J.M.G.; A Conducting
Polymer / Self-Assembled Monolayer Modified Electrode for the
Determination of Ascorbic Acid; XII Iberian Meeting of Electrochemistry &
XVI Meeting of the Portuguese Electrochemical Society; ISEL-Lisboa, Portugal;
8-11 September, page 79, 2010.
PCN10.7. Pimenta A., Araújo H., Castro R., Rivera I., Torres I. and Tavares de Almeida I.;
Homocysteine and MTHFR SNPs in childhood and adolescence – Genetic
factors of vascular disease in a large population; SPDM VII International
Symposium; Algarve, Portugal; 4-5 Novembro, 2010.
22
Organization of conferences (2000 ca.)
During the year of 2010 our group organized at the University of Madeira:
a)
The NanoSchool 2010 (11-14 October 2010). The lectures were presented by
Prof. Matthias Epple, Full Professor at the University of Duisburg-Essen, Germany (the
professor also came to Madeira to discuss ongoing collaborative work). The Materials
Group organizes this event since 2008; Number of participants: 50.
b)
Its 5th Annual Meeting in 29 January 2010, involving a total of 12 oral
communications. Number of participants: 30
In 20 January 2010, the Portuguese Biophysics Society also organized, in collaboration
with CQM, two seminars at the University of Madeira, namely:

"O papel e as actividades da Sociedade Portuguesa de Biofísica" by Prof. Manuela
Pereira (ITQB, Portugal), President of the Portuguese Biophysics Society .

"Biophysical applications of calorimetry" by Prof. Margarida Bastos (FCUP,
Portugal).
In February 2010, the Materials Group received the visit of Prof. Geoffrey Ozin to
discuss ongoing/future collaborative work. During his stay , he presented a conference
entitled “Spin of a Spin Off”.
In March 2010, the general director of the International Iberian Nanotechnology
Laboratory, Prof. José Rivas, also visited CQM for discuss ongoing/future collaborative
work. During his stay, he presented a conference entitled “O impacto das nanociências
nos dias de hoje e o INL”.
Internationalization (ca.2000). Collaborative publication, Research, Graduate
Training Networks or other forms of participation of the Research Group at the
international level) Apresentar as formas de participação dos membros integrados
do Grupo a nível internacional (exs. colaboração em publicações e redes
internacionais)
23
Beyond the national collaborations, our group has active collaborations (with joint
publications/ongoing scientific work) with:

Donghua University, College of Chemistry, Chemical Engineering and Biotechnology,
China

Center for Advanced Research in Biotechnology, University of Maryland
Biotechnology Institute, USA

Dep. of Biochemistry and Molecular Pharmacology, University of Massachusetts
Medical School, USA

Dep. of Organic Chemistry, Faculty of Chemistry, Vilnius University, Lithuania

Dep. de Química Física, Facultad de Química, Universidad de Murcia, Spain

Forschungszentrum Karlsruhe GmbH, Institut fur Nanotechnologie, Karlsruhe,
Germany

Dep. of Physical Chemistry, University of Oslo, Oslo, Norway

Dep. of Orthopaedics and Biochemistry & Molecular Genetics, Univ. of Virginia,
USA

Instituto Canario de Investigación del Cáncer, Spain

NanoScience Center, Dep. of Chemistry, University of Jyväskylä, Finland

Institut des Sciences Moléculaires, Univ. de Bordeaux I, France

Univ. of Antwerp, Belgium

Dep. de Física Fundamental y Experimental, Electrónica y Sistemas, Fac. de Física,
Univ. of La Laguna, Spain

Nanotube Research Center, National Inst. of Advanced Industrial Science and
Technology –AIST, Japan

Universidade Federal de Campina Grande, Centro de Ciências e Tecnologia, Brazil
The level of internationalization of the Materials Group in 2010 was also evident by:
a) The group integrated the COST Action TD0802- Dendrimers in Biomedical
Applications;
24
b) The group was organizer of a NanoSchool and of conferences with the participation
of foreign outstanding scientists, especially in the field of Nanochemistry and
Nanomaterials (already mentioned);
c) Prof. Xiangyang Shi is an Invited Full Professor at UMa and also researcher at
Donghua University (China);
d) The group received a Master student from Brazil;
e) The group has PhD works in collaboration with other international teams;
f) One member of the team was appointed as National Expert assigned to the Unit of
Micro and Nanosystems of the DG Information Society (INFSO G2), European
Commission, Brussels, since 2006;
g) Other team member belongs, since 2008, to the evaluation panel of COST Action
D35 - Molecular Devices (Switzerland Multilateral Research-Cooperation, Swiss
Confederation) and the evaluation panel of Information and Communication
Technologies (ICT) of the 7th FP (Small and medium scale focused research projects
(STREPs)) ;
h) The members of the group belong to several international professional societies and
are referees of several journals with international circulation.
Other publications National (6000 ca.) Referir outras publicações nacionais, de
membros integrados do Grupo, não mencionadas no item “Publications in peer
review Journals”
Government/Organization contract research (2000). Include here work carried out by
the group that resulted in a publication or report. Of particular importance are those
involved in public policy advice) Referir os contratos celebrados com entidades
governamentais da responsabilidade do Grupo
Future Research:
This section allows you to provide the future objectives for the research group.
25
1. Objectives (6000 ca.) Apresentar os objectivos previstos para o próximo ano da
responsabilidade do Grupo
For 2011, the Materials Group has the main objective to continue to focus research on
the domain of new materials at the molecular and nano scales designed to be applied
in the areas of biomedicine and optoelectronics. Indeed, unique studies were already
launched or will start in 2011 by our Group, in particular:
•
Metallodendrimers and molecular wires containing organic and metal moieties
are being developed and tested for non linear optics (second harmonic generation
materials). In addition, new strategies that combine silicon technology with molecular
chemistry are being pursued for the preparation of new optoelectronic devices, like
the spontaneously surface grafting of molecular wires to porous silicon. This approach
is of interest since it has no parallel with the chemistry of self-assembled monolayers
(SAMs) used on bulk silicon surfaces.
•
Dendrimer-based materials such as dendrimers conjugated with biological
active moieties, hybrid dendrimer-inorganic nanoparticles and materials obtained by
self-assembly of functionalized dendrimers are also under investigation and their
suitability as gene/drug delivery carriers into cells and/or as contrast agents for MRI
evaluated.
•
Another sub-topic of research deals with ceramic-based nanoparticles for
biomedical applications. Hybrid nanoparticles are being prepared based on ceramic
materials (such as clays and hydroxyapatite) and polymers (such as alginate and
environmental responsive polymers). These nanoparticles are also intended to be used
for drug and gene delivery purposes. Also, functionalization of these nanoparticles
with molecular motifs recognized by the cell membrane may allow the targeting of
specific cells, like cancer cells.
•
New strategies for encapsulation of single human cells and for controlling the
behavior of these systems under in vivo situations are being pursued - in this case, the
layer-by-layer technique (using polyelectrolytes of opposite charge) is used in
combination with magnetic nanoparticles to obtain novel constructs that can be
implanted in the body and, simultaneously, be used for gene/drug delivery.
26
•
The group is also committed with the understanding and elucidation of
mechanisms leading to materials properties and functions. A better comprehension of
experimental results is being achieved by the use of complementary computer and
theoretical modeling techniques.
•
Research on molecular recognition events using theoretical and computational
approaches (docking, molecular mechanics, QSAR, etc.) to design compounds and
study their chemical and biological properties is also an important part of our work.
The group is especially interested in developing methodologies to incorporate
chemical features in drug compounds, at the early stages of their development, which
would allow them to have a desired specificity against a panel of molecular targets and
thus address issues like drug resistance and toxicity.
It must be highlighted that a close collaboration with the local Hospital and the
existence of a cell culture facility at CQM allows the biological evaluation of the
developed biomaterials at Madeira. In particular, adult human stem cells are being
used in the studies with authorization of the Local Ethical Committee and respecting
the national and European rules. The group is also strongly committed with the
European Commission Recommendation of 07/02/2008 and voluntarily follows the
Code of Conduct for responsible Nanosciences and Nanotechnologies research, as well
as the opinion of the European Group on Ethics in Science and New Technologies in
the ethical aspects of Nanomedicine.
According with the mentioned scientific context, the group established three main
objectives for 2011:
•
To continue to increase the scientific output of the team, i.e., the number of
publications (in international peer review journals) and their impact factor;
•
To continue to increase the number of researchers in the team (namely, Post-
Doc, Master and PhD students);
•
To continue to focus on obtaining funding for research (from national and
European sources), especially to acquire scientific equipment needed for the
characterization of nanomaterials; indeed, CQM still does not have essential
techniques for materials characterization (such as SEM, TEM, AFM, etc.); these
27
analyses are being made in the mainland or abroad and usually take a long time to be
performed; when samples cannot be simply sent by mail to be analyzed, researchers
often have to travel to those places, spending unnecessary time and money (lodgment
and plane tickets).
2011 Programmed Activities

6th Edition of the annual Materials Group Meeting/CQM, January 28th 2011.

Organization of the 8th Supraphone Meeting, September 2011.

Local –Organization of the 9th International Symposium on Frontiers in Biomedical
Polymers (FBPS 2011, 9-12 May 2011, Funchal, Portugal);

Organization of the 4th edition of the Nanoschool (Guest Professor Jean-Pierre
Sauvage, from The French Academy of Sciences), October 2011.
3.
Funding, source, dates (1500 ca.)indicate in full including amount of current
and pending funding. Apresentar os financiamentos previstos para o próximo ano
(Ex. candidaturas a projectos no âmbito do Grupo e cujos resultados ainda estão
pendentes) e as fontes relativas aos mesmos
Ongoing projects and grants (Total funds allocated to the group in the period 20062014: € 859.755):
€175.000 (€129.325 for CQM): FCT funded. PTDC/SAU-BEB/71161/2006. 2007-2010
€101.200 (€101.200 for CQM): FCT funded. PTDC/QUI/64202/2006. 2008-2011
€780.000 (€100.000 for CQM): INTERREG 3B funded. BIOPHARMAC-MAC/1/M104.
2009-2012
€168.100 (€168.100 for CQM): FCT funded. PTDC/CTM/098451/2008. 2010-2013.
€157.193 (€4.730 for CQM): FCT funded. PTDC/QUI-QUI/099815/2008. 2010-2012
€ 47.040: 1 PhD grant SFRH/BD/265036/2009. 2010-2014 (Manuel Jardim)
€ 47.040: 1 PhD grant SFRH/BD/24547/2005. 2006-2010 (Carla Alves)
€ 47.040: 1 PhD grant SFRH/BD/29325/2006. 2007-2011 (João Figueira)
€ 53.820: 1 Post-Doc grant SFRH/BPD/30954/2006. 2007-2011 (Viney Lather)
€ 53.820: 1 Post-Doc grant SFRH/BPD/41787/2007. 2008-2011 (Visvaldas Kairys)
€ 53.820: 1 Post-Doc grant SFRH/BPD/44821/2008. 2009-2012 (Deepti Pandita)
28
€ 53.820: 1 Post-Doc grant SFRH/BPD/47369/2008: 2009-2012 (Alireza Nouri)
Projects and grants to be started in 2011 (approved in 2010):
€151.251 (€80.193 for CQM): FCT funded. PTDC/CTM-NAN/112428/2009. 2011-2014.
€ 53.820: 1 Post-Doc grant SFRH/BPD/75420/2010: 2011-2013 (Shili Xiao)
Pending projects (projects submitted to FCT in the last call):
€ 189.600: PTDC/CTM-NAN/119458/2010
€ 200.000: PTDC/CTM-NAN/116841/2010
€ 199.899: PTDC/CTM-BPC/116985/2010
€ 199.721: PTDC/CTM-NAN/116788/2010
29
Relatório Científico 2010 - Research Groups
(RG-Madeira-674-391) Natural Products Group
In this section of the report you have the names of each Research Group and their
Principal Investigators that were indicated in the last report. By following the link in
the groups name you will be able to access the individual form of the group.
This list includes the currently active Research Groups as well as the Research Groups
reported to be active in the previous year.

Group Description
Group Description:
Please indicate mains sources of funding for the research of your group. Include all
types of funding, like FCT projects, FCT Base, as well as funding from other institutions.
You should indicate an approximate amount in EUROS, and the source to which the
funds apply.




Research Group Title: (RG-Madeira-674-391) - Natural Products Group
Principal Investigator: Paula Cristina Machado Ferreira Castilho
Research Area: Chemistry
Home Institution: Universidade da Madeira
1. Funding, source, dates (1000 ca.) - Apresentar os financiamentos alocados
especificamente ao Grupo em questão e as respectivas fontes:
Ongoing projects and grants (Total funds allocated to the group until 2013: € 654.100):
INTERREG IIIB funded:
VinSaudeMAC “Evaluation of the bioactive effect of red wines in the prevention of atheroschlerotic, oncologic and
neurodegenerative diseases. Implementation of vinification processes to optimise the antioxidant potential of red wines”.
Approved by Interreg €617.541 (€271.000 for University of Madeira/CQM): (PCT MAC 2007-2013; 1st Call). Headed by
Natural Products Group: Principal Investigator: José S. Câmara
FCT funded:
€ 47.040 x 2 PhD grants SFRH/BD/24227/2005 and SFRH/BD/24177/2005. 2006-2010
€ 47.040 x 2 PhD grants SFRH/BD/28660/2006 and SFRH/BD/32334/2006. 2007-2011
€ 47.040 x 2 PhD grants SFRH/BD/38855/2007 and SFRH/BD/40374/2007. 2008-2012
€ 47.040 x 1 PhD grant SFRH/BD/48148/2008. 2009-2013
€ 53.820: 1 Post-Doc grant SFRH/BPD/66177/2009
Other:
NovelProBio- CYTED RED 108RT0362 : "RED IBEROAMERICANA PARA EVALUAR LA FACTIBILIDAD DEL
DESARROLLO DE NUEVOS PRODUCTOS EN LA ALIMENTACIÓN ANIMAL. APROVECHAMIENTO DE
EFLUENTES DE QUESERÍA PARA LA PRODUCCIÓN DE PROBIÓTICOS", 2008-2011. Headed by Natural Products
Group: Principal Investigator: Maria do Céu Costa
Objectives and Achievements:
This section allows you to provide the objectives and achievements during the reporting period.
1. Objectives (4000 ca.) - Apresentar os objectivos específicos do Grupo
30
The goal of the natural products research line was the establishment of capabilities in
the aspects of analysis, characterization and evaluation of core components of
foodstuffs, with special incidence in wine, and on the evaluation and identification of
bioactive components of aromatic/medicinal plants, some of them also used as food
constituents, on the search for new therapeutic lead molecules.
The research focused not only on the application but on the development of
techniques and methodologies of chemical analysis of volatile and non-volatile
compounds in food stuffs in order to characterize them and/or their processes of
production and evolution. The same methods and techniques were developed to
establish chemotypes of botanical subspecies of the Macaronesian biodiversity and to
identify and quantify the components of essential oils and extracts with the aim of
developing selected species into renewable sources of marketable products such as
pharmaceuticals, biocides, fine chemicals, fuels, foods, and supplements. The same
matrixes are characterized and evaluated for bioactive components, namely those with
antioxidant activity, a property of special relevance in food science and pharmacology.
At the same time, we aimed at building and maintaining a strong connection with the
local institutions, by developing activity in the research and improvement of Madeira
wine, a product of high economic importance, thus contributing to the development of
the insular region where we live. The inter-twining of expertise of the various member
of the research group is actively procured in order to do applied and fundamental
research to achieve our objectives. Since the group is composed primarily by chemists
and chemical engineers, national and international partnerships and collaborations
have been established with complementary groups in the fields of pharmacy,
medicine, agriculture and botany in order to maximize synergies, implement our ideas
and improve the scientific output.
Through a reasonable number and size of projects that the members were able to
secure during these years, the facilities and analytical park were much improved,
leading to the attraction of national and international researchers and the training of
existing collaborators who are by now members of the team, leaders of their own
projects.
2. Main Achievements (4000 ca.) - Apresentar os principais objectivos atingidos relativamente
ao Grupo
The group consists of 5 Ph Ds (2 members from the host institution and 2 from State
Laboratories and 1 post doc researcher), 7 PhD students (FCT funded) and 5 Master
Students and 4 collaborators. The activity of the research group is shown on the
number of projects and amount of funding obtained. In 2010, we published 8 papers in
peer reviewed journals (5 more papers were accepted for publications in international
journals with impact factor and 4 others are submitted) and two Master Thesis.
Additionally, 6 oral and 17 poster communications in scientific meetings was presented.
31
A new partnership with the Regional Direction of Agriculture was established with the
aim of evaluating the vitamin contents of fresh produce from biological and
conventional agriculture.
Future Research
Objectives
The general objectives of the group can be summarized as being able to characterize
and evaluate the potentiality as health agents of natural products of vegetal origin and
to discover new ways to increase that potential. The design of new methodologies and
establishment of goals in the area of research rends irrelevant to type of matrix we
start with, so any food or beverage of plant becomes a source of “natural products” in
the sense that it is alive and changes naturally and can be further changed by the
researcher intervention in the direction chosen by the researcher. In future projects
the emphasis will be in the impact in human health of natural products (sensu latu)
and their analogs and derivatives.
The cooperation with other Portuguese universities, such as Univ Aveiro in the area of
detection and characterization of volatile biomarkers in oncologic and allergic
pathologies, application of solid-phase microextraction (SPME) followed by unidimensional (1D) and two dimensional (2D) chromatographic techniques will be
actively pursued.
Group Productivity: (Publications in peer review Journals, Other international publications,
Ph D Thesis completed, Patents and prototypes, Organization of Conferences, Industry
contract research, Internationalization, Government/Organization of contract research)
PUBLISHED PAPERS IN PEER REVIEW JOURNALS (IF 2009)
10.1. Branco P. C.; Castilho P. C.; Rosa M. F. and Ferreira J.; Characterization of Annona
cherimola Mill. Seed Oil from Madeira Island: a Possible Biodiesel Feedstock; J. Am. Oil
Chem. Soc., 87: 429 - 436; 2010 (IF: 1.965).
10.2. Gouveia S.C. and Castilho P.C.; Characterization of phenolic compounds in Helichrysum
melaleucum by high-performance liquid chromatography with on-line ultraviolet and mass
spectrometry detection; Rapid Commun. Mass. Sp., 24: 1851-1868; 2010 (IF: 2.695]
10.3. Juan P.; Pérez-Trujillo J. P.; Conde J. E.; Pérez-Pont M. E.; Câmara J. S. and Marques J.C.;
Content in metallic ions of wines from the Madeira and Azores archipelagos; Food Chem.,
124: 533 - 537; 2010 (IF: 3.146).
10.4. Pereira A.C.; Reis M. S.; Saraiva P. M and Marques J.C.; Analysis and assessment of
Madeira wine ageing over an extended time period through GC–MS and chemometric
analysis; Anal. Chim. Acta, 660: 8 - 21; 2010 (IF: 3.757).
32
10.5. Pereira A.C.; Reis M. S.; Saraiva P. M. and Marques J. C.; Aroma ageing trends in GC/MS
profiles of liqueur wines; Anal. Chim. Acta, 659: 93-101; 2010 (IF: 3.757).
10.6. Pereira V.; Câmara J. S.; Cacho J. and Marques J. C.; HPLC-DAD methodology for the
quantification of organic acids, furans and polyphenols by direct injection of wine samples; J.
Sep. Sci., 33: 1 - 12; 2010 (IF: 2.551).
10.7. Perestrelo R.; Petronilho S.; Câmara J. S. and Rocha S. M.; Comprehensive twodimensional gas chromatography with time-of-flight mass spectrometry combined with
solid phase microextraction as a powerful tool for quantification of ethyl carbamate in
fortified wines. The case study of Madeira wine; J. Chromatogr. A, 1217: 3441 - 3445; 2010
(IF: 4.101).
10.8. Rudnitskaya A.; Rocha S. M.; Legin A.; Pereira V. and Marques J. C.; Evaluation of the
feasibility of the electronic tongue as a rapid analytical tool for wine age prediction and
quantification of the organic acids and phenolic compounds. The case-study of Madeira
wine; Anal. Chim. Acta, 662: 82 - 89; 2010 (IF: 3.757).
PUBLISHED PAPERS IN INTERNATIONAL JOURNALS WITH PEER REVIEW BUT WITHOUT
IMPACT FACTOR
WF10.1. Costa M.C.; Nogueira T.; Ferreira H.P.; Martins A.P.; Os suplementos alimentares e a
saúde. Papel do farmacêutico na utilização de plantas; Revista de Fitoterapia 10 (2): 127144;2010.
ACCEPTED PAPERS IN PEER REVIEW JOURNALS
AP10.1.
Gouveia S.C., Castilho P.C.; Helichrysum monizii Lowe: Phenolic composition and
antioxidant potential; Phytochemical Analysis; DOI 10.1002/pca.1326 (IF: 1.744)
AP10.2.
Pereira J.; Pereira J.; Câmara J.S.; Effectiveness of different solid-phase microextraction
fibres for differentiation of selected Madeira island fruits based on their volatile metabolite
profile
-
identification
of
novel
compounds.
Talanta,
83:
899-906;
2011;
doi:
10.1016/j.talanta.2010.10.064 (IF: 3.290).
AP10.3.
Perestrelo R., Petronilho S., Câmara J.S., Rocha. S.M.; In-depth search focused on furans,
lactones, volatile phenols, and acetals as potential age markers of Madeira wines by
comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry
combined with solid phase microextraction. Journal Agricultural and Food Chemistry, 2010 (IF:
2.469).
33
AP10.4.
Pérez-Trujillo J. P., Conde J. E., Pérez Pont M. L., Marques J. C., Câmara J.S.; Content in
metallic ions of wines from the Madeira and Azores archipelagos. Food Chemistry 2010; doi:
10.1016/j.foodchem.2010.06.065 (IF: 3.146).
AP10.5.
Pontes M., Pereira J.; Câmara J.S.; Dynamic headspace solid-phase microextraction
combined with one-dimensional gas chromatography-mass spectrometry as a powerful tool to
differentiate banana cultivars based on their volatile metabolite profile. Food Chemistry 2010
(IF: 3.146).
SUBMITTED PAPERS TO PEER REVIEW JOURNALS
SP10.1.
Gouveia S.C., Castilho P.C.; Separation and characterization of phenolic acids
derivatives and flavonoids from different morphological parts of Helichrysum obconicum by
a RP-HPLC-DAD-(-)-ESI-MSn method (submitted).
SP10.2. Silva C.; Pereira J.; Van Goolen W.; Giró C.; Câmara J.S.; A reverse-phase solid phase
extraction using a new hydrophilic-lipophilic balanced sorbent combined with ultraperformance liquid chromatography for the determination of significant bioactive
metabolites in wines. The case study of polyphenol compounds (submitted).
SP10.3. Silva C.; Pereira J.; Van Goolen W.; Giró C.; Câmara J.S.; Investigation of urinary
volatile
organic
metabolites
as
potential
cancer
biomarkers
using
solid-phase
microextraction followed by one-dimensional gas chromatography-mass spectrometry
methodology (submitted).
SP10.4. Perestrelo R.; Rocha. S.M.; Câmara J.S.; Development and evaluation of an analytical
approach based on solid-phase microextraction and one-dimensional gas chromatographymass spectrometry for establishment of the global volatile signature in pulp and skin of Bual
and Bastardo Vitis vinifera L. grape varieties. Talanta (submitted).
THESIS
TH10.1. Gouveia N.N.F., Validação de uma metodologia analítica para determinação de aminas
biogénicas em tunídeos, thesis presented to obtain the MSc degree, Universidade da
Madeira, 2010.
TH10.2. Carvalho M.J.M., Caracterização e isolamento de compostos bioactivos do fungo
Laurobasidium lauri (Madre de Louro), thesis presented to obtain the MSc degree,
Universidade da Madeira, 2010.
34
ABSTRACTS IN SCIENTIFIC INTERNATIONAL MEETINGS
ORAL COMMUNICATIONS
OCI10.1. Caldeira M., Câmara J.S., Rocha Sílvia M.; In-deep study of metabolites from
oxidative stress in breath: a challenge to allergic asthma diagnosis; 12th International
Symposium on Advances in Extraction Technologies; Poznan, Poland; 20-22 September,
2010.
POSTER COMMUNICATIONS
PCI10.1. Branco P.C.; Torrado I.; Roseiro L.; Rodrigues A.I.: Silva T.L.; Carvalheiro F; Castilho P.C.;
Duarte L.C.; Annona (Annona cherimola Mill.) seeds: A novel biorefinery feedstock?; The
Fourth Annual Workshop of COST FP0602 – Biotechnical Processing of Lignocellulosic Raw
Materials; Izmir, Turkey; 21-24 September, page 59, 2010.
PCI10.2. Branco P.C.; Torrado I.; Carvalheiro F.; Castilho P.C.; Duarte L.C.; Optimisation and
mathematical modelling of custard apple seeds dilute acid hydrolysis; Biomass derived
pentoses: from biotechnology to fine chemistry; Reims, France, 14-16 November, page 90,
2010.
PCI10.3. Caldeira M., Câmara J.S., Rocha Sílvia M.; Exhaled breath analysis: from one
dimensional to comprehensive two-dimensional chromatography; 34th International
Symposium on Capillary Chromatography (ISCC) and 7th GcxGC Symposium; Riva del Garda,
Italy; 1-4 June, 2010.
PCI10.4. Caldeira M., Câmara J.S., Rocha Sílvia M.; Profiling oxidative stress markers in
allergic asthma by analysis of exhaled breath using comprehensive two-dimensional
chromatography; Exhaled breath analysis: from sensors to applications; Barga, Italy;
24-29 October, 2010.
PCI10.5. Câmara J.S., Silva P., Silva C., Perestrelo R.. Optimization of solid-phase
microextraction influencing parameters followed by one-dimensional gas chromatographymass spectrometry for detection of breast cancer biomarkers, 34th International
Symposium on Capillary Chromatography, Riva del Garda, 1-4 May, 2010.
35
PCI10.6. Mendes B., Gonçalves J., Câmara J.S.; Effectiveness of two extraction methods to
determine the volatile signature of Madeira wines; ExTech 2010; Poznań, Poland; 20-22
September, 2010.
PCI10.7. Pereira J.; Pereira J.; Câmara J.S.; Comparison of the fiber efficiencies in the extraction
of volatile and semivolatile compounds from kiwi (Actinidia deliciosa) fruit. 34th
International Symposium on Capillary Chromatography, Riva del Garda, Italy, June 1st-4th
2010.
PCI10.8. Pereira J.; Pereira J.; Câmara J.S.; Characterization of selected Madeira Islands fruit
volatile compounds by SPME-GC-qMS. 34th International Symposium on Capillary
Chromatography, Riva del Garda, Italy, June 1st-4th, 2010.
PCI10.9. Silva C.; Pereira J.; Van Goolen W.; Giró C.; Câmara J.S.; A reverse-phase SPE using a
new hydrophilic-lipophilic balanced sorbent combined with an ultra-fast technique for the
determination of significant bioactive phenolic compounds in wines. ExTech 2010, Poznao,
Poland, 20-22nd September 2010.
PCI10.10. Perestrelo R., Barros A.S., Caldeira M., Câmara J.S., Rocha S.M.; HS-SPME combined
with GC × GC-ToFMS as a powerful methodology to in-depth search of potential age
markers in Madeira wines, ExTech2010, Poznań, 20-22 September, 2010.
PCI10.11. Perestrelo R., Petronilho S., Câmara J.S., Rocha S.M.; Determination of ethyl
carbamate in fortified wines using comprehensive two-dimensional gas chromatography
with time-of-flight mass spectrometry combined with solid phase microextraction, 7th GC ×
GC Symposium, Riva del Garda, 1-4 May, 2010.
ABSTRACTS IN SCIENTIFIC NATIONAL MEETINGS
ORAL COMMUNICATIONS
OCN10.1. Figueiredo R.; Menezes J.C.; Silva P.E.A., Pando R.H.; Castilho P. and Costa M.C.;
Improving what Nature provides: Tuberculosis and the ansamycins case study; BIOPHARMAC
Meeting, Universidade da Madeira - Funchal, 20 -22 October; 2010.
OCN10.2. Gouveia S.C. and Castilho P.C.; Phenolic compounds from Helichrysum obconicum:
n
th
HPLC-DAD-ESI-MS characterization; 4 Portuguese Mass Spectrometry Meeting, MS2010;
Lisboa, Portugal; 13-15 December, page 7, 2010.
36
OCN10.3.
Pereira J. and Câmara J.S.; “Exploring bioactive compounds in wines for human
health benefits” (invited communication), Expert Training Course, BIOPHARMAC Project,
Funchal, Portugal, 20-22nd October 2010.
OCN10.4.
Perestrelo R., Barros A.S., Câmara J.S. and Rocha S.M.; From grape to wine:
searching for varietal, ageing markers, and contaminants using SPME combined with GC
based methodologies, Workshop SPME 2010, Universidade de Aveiro, November, 2010.
OCN10.5.
Perestrelo R., Câmara J.S. and Rocha S.M.; GC × GC – ToFMS as a powerful tool for
deep insight into chemistry of Madeira wine: establishment of new age markers and
searching for ethyl carbamate, a possible human carcinogen compound, Jornadas da
Unidade QOPNA, Aveiro, May, 2010.
POSTER COMMUNICATIONS
PCN10.1.
Castilho P.C., Gouveia S.C. and Carvalho M.J.; Characterization of A-type and Bth
type proanthocyanidins of Laurobasidium lauri by RP-HPLC-ESI(-)-MS/MS; 4 Portuguese
Mass Spectrometry Meeting, MS2010; Lisboa, Portugal; 13-15 December, page 52, 2010.
PCN10.2.
Gouveia S.C., Gonçalves J. and Castilho P.C.; Antioxidant activities and phenolic
composition of crude extracts from flowers of Andryala glandulosa; 2
nd
Portuguese Young
Chemists Meeting, Aveiro, Portugal; 21-23 April, page 153, 2010.
PCN10.3.
Gouveia S.C. and Castilho P.C.; Helichrysum monizii Lowe: Phenolic profile
n
th
determination by LC-DAD-ESI-MS ; 4 Portuguese Mass Spectrometry Meeting, MS2010;
Lisboa, Portugal; 13-15 December, page 65, 2010.
PCN10.4.
Gouveia S.C. and Castilho P.C.; Phenolic compounds from Helichrysum obconicum:
n
th
HPLC-DAD-ESI-MS characterization; 4 Portuguese Mass Spectrometry Meeting, MS2010;
Lisboa, Portugal; 13-15 December, page 7, 2010.
PCN10.5.
Perestrelo R., Petronilho S., Câmara J.S. and Rocha S.M.; GC × GC-ToFMS combined
with HS-SPME as a powerful methodology for quantification of ethyl carbamate in fortified
wines, 2nd Portuguese Young Chemists Meeting, Aveiro, 21-23 April, page 146, 2010.
PCN10.6.
Silva C.L., Perestrelo R. and Câmara J.S.; Analysis of urinary volatile metabolites as
potential breast cancer biomarkers using HS-SPME/GC-qMS, 2nd Portuguese Young
Chemists Meeting, Aveiro, 21-23 April, page a/2, 2010.
37
OTHER (NATIONAL) PUBLICATIONS
ONP10.1.
Caldeira, L.R., Castilho, P.C., Dias-Ferreira, C. “Levantamento das Características
Bioquímicas, Organolépticas e Nutricionais de alguns Hortofrutícolas” relatório
para o Gabinete de Promoção do Comercio Agroalimentar, Março, 2010
ONP10.2.
Caldeira,L.R., Castilho, P.C., Dias-Ferreira, C. “Doseamento da Vitamina C em
espécies hortofrutícolas produzidas na RAM” relatório para o Gabinete de
Promoção do Comercio Agroalimentar, Julho, 2010
ONP10.3.
Oliveira, F; Ferreira. R., Castilho, P.C. “Avaliação do potencial energético da
biomassa vegetal da RAM (parte II)” relatório para AREAM, Março, 2010.
ONP10.4.
Oliveira, F; Ferreira. R., Castilho, P.C. “Determinação das Características Físicoquimicas do bagaço de cana sacarina produzida na RAM” relatório para AREAM,
Julho, 2010.
Ongoing PhD Thesis:
1. Vanda Pereira: Efeito do Processo de Estufagem na formação de compostos
aromáticos típicos do vinho madeira, SFRH/BD/24177/2005. Supervisor:
José C. Marques. A joint PhD with University of Zaragoza, Spain.
2. Sandra Gouveia: Isolamento e caracterização de princípios activos de plantas
superiores para o combate à Tuberculose, SFRH/BD/24227/2005. Supervisor: Paula
Castilho.
3. Ana Cristina Pereira: “Caracterização química e hierarquização (por quimiometria)
dosenvelhecimento de vinhos fortificados”, SFRH/BD/28660/2006.
Co-supervisor: José C. Marques. A joint PhD with University of Coimbra, Portugal.
4. Pedro Miguel Sena da Costa Branco: Valorização integrada de Produtos Residuais
das Industrias de transformação de Frutas da Madeira,
SFRH/BD/32334/2006. Supervisor: Paula Castilho.
5. Rosa Maria de Sá Perestrelo: Evaluation of the aroma potential of Vitis Vinifera L.
cultivars used in Terras Madeirenses winemaking. Influence of addition exogenous
enzymes and polymeric fraction in the wine aroma proprieties, SFRH/BD/38855/2007.
Supervisor: José Câmara. A joint PhD with University of Aveiro, Portugal.
6. Michael Manuel Lima Caldeira: Development of a methodology to detect biomarkers
of allergic respiratory diseases based on the solid phase microextraction coupled to
chromatographic techniques. Contributions to the development of a diagnostic means,
SFRH/BD/40374/2007. Supervisor: José Câmara. A joint PhD with University of
Aveiro, Portugal.
7. Tatiana de Sousa Weinhold: Avaliação fitoquímica e actividade anti-microbiana e
insecticida de plantas aromáticas da família das Labiatae, SFRH/BD/48148/2008.
Supervisor: Paula Castilho.
38
Ongoing Master Thesis:
1.
“VOCsBREAST. IDENTIFICATION AND CHARACTERIZATION OF VOLATILE ORGANIC COMPOUNDS
AS POTENTIAL BIOMARKERS OF BREAST CANCER”; Silva P.C.; Thesis to obtain MSc degree;
Universidade da Madeira. Supervisor: José Câmara.
2.
“AVALIAÇÃO DO EFEITO DA INGESTÃO DE VINHO TINTO NO COMPORTAMENTO DE
MARCADORES ASSOCIADOS A FACTORES DE RISCO DE DOENÇAS CARDIOVASCULARES”; Mendes
B.; Thesis to obtain MSc degree; Universidade da Madeira. Supervisor: José Câmara.
3.
“A NOVEL MULTI RESIDUE APPROACH FOR POLAR PESTICIDES DETERMINATION BASED ON
QUECHERS COMBINED WITH SOLID-PHASE EXTRACTION AND LIQUID CHROMATOGRAPHYTANDEM MASS SPECTROMETRY. APPLICATION AT TWO CASE STUDIES – FOOD AND FORENSIC
TOXICOLOGY”; Sousa J.; Thesis to obtain MSc degree; Universidade de Coimbra. Supervisor:
José Câmara with de co-supervision of Profª Emília Pimenta da Faculdade de Ciências da
Universidade de Coimbra.
4.
“REDUÇÃO DOS TEORES DE CARBAMATO DE ETILO EM VINHOS PROCESSADOS TERMICAMENTE:
DESENVOLVIMENTOS AO NÍVEL DO PROCESSO DE OBTENÇÃO DO VINHO”. Martins C.; Thesis to
obtain MSc degree; Universidade de Aveiro. Supervisor: Silvia M. Rocha (UA) with de cosupervision of José Câmara (UMa).
5.
“CARACTERIZAÇÃO DO PERFIL METABÓLICO VOLÁTIL DO AR EXALADO COMO MEIO PARA
IDENTIFICAR POTENCIAIS BIOMARCADORES DO CANCRO DO PULMÃO”; Silva A..; Thesis to
obtain MSc degree; Universidade da Madeira. Supervisor: José Câmara.
6.
“Chemical and sensory evaluation of edible oils flavored with essential oils
and aromatics plants extracts from Madeira”; Erica T.V.; Thesis to obtain the
MSc degree; Universidade da Madeira; 2010/11. Supervisor: Paula Castilho.
7.
“New methods for ascorbates’ determination in fresh produce” Vitor Spinola Thesis
to obtain the MSc degree; Universidade da Madeira; 2010/11. Supervisor:
Paula Castilho.
Internationalization (ca.2000). Collaborative publication, Research, Graduate
Training Networks or other forms of participation of the Research Group at the
international level) Apresentar as formas de participação dos membros integrados
do Grupo a nível internacional (exs. colaboração em publicações e redes
internacionais)
39
Publications during 2010 showed predominantly results of national collaborations.
However, the international form of cooperation are still ongoing and new ones are
being pursuited : all the work on the isolation, characterization and evaluation of
metabolites of plant origin will proceed with special incidence on those with antitumor
and antituberculosis activity, taking advantages of the cooperation established before
with the Instituto Canario de Investigacion en Cancer and the Instituto Politecnico
Nacional of Mexico, respectively. During 2010, a new partnership was established with
the Institute of Tuberculosis Research, University of Chicago Illinois.
Our ongoing collaborations with foreigners universities and institutions will not only
maintained but extended with joint proposals to CYTED and INTERREG projects: during
2010 some join projects were submitted which, albeit not approved due to lack of
funds, established contact between 11 research groups from 6 countries.
40