Annual Scientific Report 2012 - Centro de Química da Madeira

Transcrição

Annual Scientific
Report 2012
Funchal, December 2012
 CQM - Centro de Química da Madeira/Madeira Chemistry Research Centre
University of Madeira – Funchal – Portugal, 2013
Reproduction is authorized provided the source is acknowledged
Annual Scientific Report 2012
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THE RESEARCH UNIT IS SUPPORTED BY THE
FCT-IP Research Unit Number: 674
(CHEM-Madeira-Funchal-674 - PEst-OE/QUI/UI0674/2011)
CONTACT D ETAILS
Centro de Química da Madeira
Universidade da Madeira
Campus da Penteada
Funchal, 9020-105
Portugal
Tel: +351 291 705150
Fax: + 351 291 705149/249
E-mail: [email protected]
Website: http://cqm.uma.pt
Twitter: http://twitter.com/UMa_CQM
Facebook: http://on.fb.me/gqSeD9
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T ABLE OF C ONTENTS
Governance Structure ..........................................................................................................7
Executive Committee ............................................................................................................... 7
Management ............................................................................................................................ 7
Permanent External Scientific Advisory Commission .............................................................7
Organizational Structure ......................................................................................................8
Vision and Mission...............................................................................................................9
Our Vision ................................................................................................................................. 9
Our Mission .............................................................................................................................. 9
Our Philosophy ......................................................................................................................... 9
Working Areas and Research Groups ...................................................................................... 9
Our Logo ................................................................................................................................... 9
CQM Commitments and Principles ..................................................................................... 10
Objectives and Achievements 2012 .................................................................................... 11
1. Unit Description ................................................................................................................. 11
2. General Objectives ............................................................................................................. 12
3. Main Achievements During the Year of 2012 .................................................................... 13
Activities ........................................................................................................................... 15
1. Integrative/Multidisciplinary Activities During the Year of 2012 ...................................... 15
2. Outreach Activities During the Year of 2012 ..................................................................... 15
Scientific Report of the Materials Group............................................................................. 17
Group Description .................................................................................................................. 17
Funding, Source(s), Dates ...................................................................................................... 17
Objectives and Achievements ................................................................................................ 18
 Objectives .................................................................................................................... 18
 Main Achievements ..................................................................................................... 19
Distinctions, Awards and Merits ............................................................................................ 19
Group Productivity ................................................................................................................. 20
 Published Articles in Peer-Reviewed Journals (IF of 2011) .......................................... 20
 Proceedings With Peer Review .................................................................................... 23
 Published Papers in International Journals With Peer Review But Without Impact
Factor ........................................................................................................................... 23
 Accepted Papers in Peer-Reviewed Journals ............................................................... 23
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 Submitted Papers to Peer Review Journals ................................................................. 24
 Thesis ........................................................................................................................... 25
 Abstracts in International Scientific Meetings ............................................................. 26
- Oral Communications ....................................................................................... 26
- Poster Communications ................................................................................... 27
 Abstracts in National Scientific Meetings .................................................................... 28
Organization of Conferences ................................................................................................. 29
Internationalization................................................................................................................ 30
Programmed activities for 2013............................................................................................. 31
Scientific Report of the Natural Products Group ................................................................. 33
Group Description .................................................................................................................. 33
Funding, source(s), dates ....................................................................................................... 33
Objectives and Achievements ................................................................................................ 34
 Objectives .................................................................................................................... 34
 Main Achievements ..................................................................................................... 34
Distinctions, Awards and Merits ............................................................................................ 35
Group Productivity ................................................................................................................. 35
 Published Articles in Peer-Reviewed Journals (IF of 2011) .......................................... 35
 Book Chapters .............................................................................................................. 37
 Proceedings With Peer Review .................................................................................... 37
 Published Papers in International Journals With Peer Review But Without Impact
Factor ........................................................................................................................... 37
 Accepted Papers in International Journals .................................................................. 37
 Submitted Papers ........................................................................................................ 38
 Thesis ........................................................................................................................... 38
 Abstracts in International Scientific Meetings ............................................................. 38
 Abstracts in National Scientific Meetings .................................................................... 41
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Organization of conferences .................................................................................................. 42
Internationalization................................................................................................................ 43
Programmed activities for 2013............................................................................................. 43
CQM Facts and Figures....................................................................................................... 44
Human Resources .................................................................................................................. 44
Budget 2004-2016 .................................................................................................................. 45
Publications 2004-2012.......................................................................................................... 46
CQM bibliometric results 2007- 2010 .................................................................................... 48
Happenings at CQM in 2012 ............................................................................................... 51
Acknowledgments ............................................................................................................. 52
Appendix........................................................................................................................... 53
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G OVERNANCE S TRUCTURE
EXECUTIVE COMMITTEE
João Rodrigues | SCIENTIFIC COORDINATOR
Helena Tomás | MATERIALS GROUP DIRECTOR
Paula Castilho | NATURAL PRODUCTS GROUP DIRECTOR
MANAGEMENT
Emília Pimenta |PROJECT MANAGER
Énio Freitas | SECRETARIAT
Paula Andrade | ADMINISTRATIVE AND TECHNICAL STAFF
P ERMANENT E XTERNAL S CIENTIFIC A DVISORY COMMISSION
| Professor José Martinho Simões
Full Professor FCUL- Faculdade de Ciências, Universidade de Lisboa, Portugal
| Professor Gordon Cragg
Retired Chief, Natural Products Branch, National Cancer Institute, USA
| Professor Makoto Fujita
Full Professor, Department of Applied Chemistry, University of Tokyo, Japan
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O RGANIZATIONAL S TRUCTURE
Scientific
Board
Permanent External Scientific
Advisory Commission
Scientific
Coordinator
Secretariat
Executive
Committee
Research
Groups
Natural Products
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Materials
V ISION AND MISSION
OUR VISION
Making the CQM a renowned research institution in the field of Natural Products and
Materials.
OUR MISSION
CQM – Madeira Chemistry Research Centre – constitutes a central element in the
promotion and enlivening of R&D activities in the field of the Chemistry and Biochemistry in
the Autonomous Region of Madeira, Madeira Island, Portugal. CQM is strongly interested in
the development of advanced training, partnerships with national and international
institutions, offer of services to the community and in the popularization of science.
OUR PHILOSOPHY
To be a relevant part of a scientific community that performs world-class research
aimed at improving the scientific knowledge and the well-being of the Society.
WORKING AREAS AND RESEARCH GROUPS
CQM is organized in two interdisciplinary research
groups – Materials and Natural Products – developing its
R&D activities in the fields of Analytical Chemistry, Food
Chemistry, Health, Materials, Molecular Modelling
Nanochemistry and Phytochemistry.
OUR LOGO
The CQM logo is composed of different colored
petals, each one representing different areas of chemistry
and biochemistry working together to improve scientific
knowledge and contribute to the well-being of Society.
A permanent
quest for
sustainable
knowledge and
excellence in the
field of Natural
Products and
Materials
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CQM COMMITMENTS AND P RINCIPLES
CQM follows the rules of Fundação para a Ciência e a Tecnologia (FCT-IP), the
European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers
(Commission Recommendation, Brussels, 11.3.2005, 2005/251/EC) since 2008, being
committed with the principle of equity in employment and selection based on merit.
CQM follows the Code of Conduct from the University of Madeira and is strongly
committed with all the European regulation related with the ethical, legal and social aspects
(ELSA) and governance of nanotechnology, namely
with the COMMISSION
RECOMMENDATION of 07/02/2008. CQM also voluntary follows the Code of Conduct for
responsible Nanosciences and Nanotechnologies research and the opinion of the European
Group on Ethics in Science and New Technologies concerning the ethical aspects of
Nanomedicine.
Part of the research that is being conducted at CQM is in close collaboration with the
local Hospital and the existence of a cell culture facility at CQM allows the biological evaluation
of the developed materials at Madeira (e.g. cytocompatibility studies, gene delivery studies). In
particular, adult human stem cells are being used in the studies with authorization of the Local
Ethical Committee and respecting the national and European rules.
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O BJECTIVES AND A CHIEVEMENTS 2012
1. UNIT DESCRIPTION
CQM is a research unit launched in 2004, hosted by the University of Madeira (UMa),
Madeira Island, an outermost region of Europe. While having scientific and strategic
autonomy, CQM is integrated into the Competence Center of Exact Sciences and Engineering
(CCESE), a university structure that aggregates the previous Departments of Chemistry,
Mathematics and Engineering, and Physics.
At the end of 2012, the CQM’s team was composed of 49 researchers:
a) 11 PhD members, corresponding to the permanent staff (8 from the CCESE and
the Competence Center of Life Sciences, 1 from R&D governmental labs, 1
contracted in the scope of the Ciência 2008 program, and 1 sponsored by the
Santander Totta Bank (Invited Research Chair in Nanotechnology));
b) 6 Post-Doc fellows;
c) 32 registered collaborators/Students (including 11 researchers holding a
Master’s degree, 9 PhD Students, 7 Master Students and 5 other graduate
researchers);
d) 16% of expatriates and 53% of women.
The center is organized into two interdisciplinary research groups (Natural Products
and Materials), each led by a senior PhD member (group director/principal investigator) from
the permanent staff.
The research unit is managed by: a) The scientific coordinator; b) The scientific board
(SB); c) The executive committee (EC). The scientific coordinator is a PhD permanent member
of staff who is responsible for representing the Unit in all R&D aspects. The scientific
coordinator is elected by the SB for a period of 2 years. The last election for the scientific
coordinator occurred in January 2013. The SB (composed of all the PhD permanent members
of staff) establishes the main rules and guidelines for the CQM management, along with the
scientific strategy for the Unit. The EC is formed by the scientific coordinator and two other
PhD members (usually, the 2 group directors), and has the role of implementing the decisions
of the SB.
The management of CQM considers the opinion of a Permanent External Scientific
Advisory Commission (PESAC) consisting of: Professor Martinho Simões from Lisbon Univ.
(Portugal), Professor Gordon Cragg, Retired Chief of the National Cancer Institute (USA) and
Professor Makoto Fujita from the Department of Applied Chemistry, Univ. of Tokyo (Japan).
The coordination of special activities/projects (such as post-graduate courses, outreach
science actions, etc.), maintenance and management of important equipment, such as the
400MHz NMR and LCMSMS equipment, as well as safety and lab space management can be
assigned to specific CQM members.
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CQM also benefits from the work of two administrative staff members belonging to
UMa (on a part-time basis) for the financial management of R&D projects (including the FCT-IP
pluriannual budget).
CQM’s pluriannual base funding from FCT-IP is based on the center’s last FCT-IP
evaluation exercise (a classification of “Good” was obtained in the last evaluation – 2008). The
amount attributed in 2012 was €42.020 (15% of this value corresponds to University
overheads). CQM’s financial strategy is to primarily prioritize the common interests of the
whole Unit (equipment maintenance, as well as common consumables, such as gases and
cryogenic liquids, etc.), and if possible, to invest in the acquisition of new equipment. The
remaining budget is distributed among the permanent PhD staff members, according to their
requirements. In 2012, roughly 60% of our annual budget was spent on common expenses.
2. GENERAL OBJECTIVES
CQM’s main objective is to be a leading international R&D entity in the field of
Materials and Natural Products, thus contributing to the development of the University of
Madeira and the Archipelago of Madeira, and also for social and economic growth and
cohesion within Portugal and Europe. CQM aims to become a R&D center where new
fundamental knowledge is produced and solutions to real world problems are created with
potential to be converted into practical, scalable, and marketable products and processes.
Furthermore, CQM wants to generate a R&D environment adequate for advanced training at
UMa, simultaneously fostering the attraction of outstanding students and researchers. It is
also our aim to contribute to the promotion of the scientific culture among the general
population, in particular the younger generation. It should be highlighted that CQM is the only
existent research unit in all of the Madeira Archipelago with a strong knowhow in Chemistry.
In order to achieve these general objectives, we aim to:
a) Focus on R&D activities, taking into consideration the expertise of the CQM
members, the geographical location of the unit, and the strategic areas in terms of
R&D activities defined for the near future by the University of Madeira (its
development plan for 2010-2013), the National and the Regional Governments
(nanotechnology and health sciences), as well as the European Union. Indeed, since
the beginning, CQM made a decision to direct efforts towards applied research with
high local impact (Natural Products, with a strong component of Analytical
Chemistry) and, simultaneously, to choose a more demanding and emergent field
of research that could increase the international visibility of UMa (Materials,
namely Nanomaterials for biomedical and optoelectronic applications).
b) Strengthen the two research groups by increasing the number of PhD members,
PhD students and Master students. We have a permanent open call on our website
for PhD students and Post-Doc researchers; this has also been announced on
international websites (e.g. Nature Jobs and the EURAXESS Jobs Portal). Indeed,
over the past few years, we have submitted a large number of applications to the
FCT program for “Advanced Training and Qualification of Human Resources”;
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c) Reinforce the center with necessary/crucial equipment not yet available at our
University, either through research project funding or through national programs
dedicated to equipment acquisition;
d) Establish new national and international collaborations, while empowering the
existing ones, with institutions able to support and complement our research;
e) Promote the ongoing research at CQM at the national and international levels;
f) Search for funds by submitting project proposals at the national and international
levels, along with other national and international partners;
g) Reinforce the interactions between both research groups at CQM by launching
more collaborative research projects;
h) Increasing and improving the number and quality of publications (Impact Factor),
an objective that will certainly be fulfilled in the following years as a result of the
work being performed up to now;
i) Give the needed scientific support to the post-graduate courses offered by UMa
(namely, the Master’s degree program in “Applied Biochemistry” and the Master’s
degree program in “Nanochemistry and Nanomaterials”);
j) Maintain active the ongoing projects on the popularization of science that are
devoted to the general public.
3. MAIN ACHIEVEMENTS DURING THE YEAR OF 2012
The following main achievements must be highlighted for 2012:
1. Papers in peer-reviewed journals with IF: 43 (plus 17 accepted). Internationalization
(42%): 18 of the 43 papers were published in co-authorship with teams from other
countries;
2. Book and book chapters: 1 book chapter (plus 2 accepted);
3. Papers in peer-reviewed journals without IF: 2 (journals recently launched) ;
4. Conference proceedings: 1 (with impact factor);
5. Technical and scientific reports: 4;
6. Oral communications: 27 (8 in international conferences, including 2 invited
lectures);
7. Seminars at other universities: 3;
8. Posters: 43 (30 in international conferences);
9. PhD Thesis Defenses: 0; Master Thesis Defenses: 5;
10.Press articles and TV news: 78 (9 min in TV prime time);
11.Number of international conferences and advanced schools organized or coorganized by CQM team members: 2 (XIV Iberic Meeting of Electrochemistry & XVII
Meeting of the Portuguese Electrochemical Society; Nanoschool 2012);
12.Number of national conferences or advanced schools organized or co-organized by
CQM team members: 1 (7th Annual Meeting of the Materials Group);
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13.Number of short courses organized by CQM team members: 2 (1st course on
“Fundamentals and Applications of Electrospinning Technology”; 2nd edition of the
NMR course “Short theoretical and practical introduction in the NMR technique”);
14.Number of visiting fellows: 7 (Turkey (2), China (1), France (1), Germany (1),
Portugal (1), USA (1));
15.Number of advanced training students: 9 PhD Students; 7 Master Students;
16.Networking: 7; CQM is a full member of the following Portuguese networks:
National Nuclear Magnetic Resonance Network (PTNMR; http://ptnmr.dq.ua.pt),
National Mass Spectrometry Network (RNEM; http://rnem.fc.ul.pt/) and
Nanotechnology (PortugalNano; http://www.portugalnano.org), all supported by
FCT-IP. At the international level, CQM also integrated the COST Action TD0802
(Dendrimers in Biomedical Applications), the CYTED RED IBEROAMERICANA,
BIOPHARMAC and the INDIGO-ERA NET;
17.The ongoing research projects and grants at CQM together with the CQM’s
pluriannual base funding (FCT-IP) represented a total of around € 462.104 in 2012;
a funding of € 842.708 is secured for 2013 and 2014;
18.Prizes and awards: 2 (1 award from Sociedade Portuguesa de Senologia as a
recognition of the work done in the field of cancer; 1 award for the best poster at
the 36th International Symposium on Capillary Chromatography 2012);
19.Popularization of science activities: 2 (“Ocupação Científica de Jovens nas Férias
/Scientific occupation of young students during holiday time” which enrolled 16
highschool students for 1 week; “A Química é Divertida/Chemistry is Fun” which
correspond to a set of scientific activities during 1 week for the general population);
20.While having scientific and strategic autonomy, the CQM seeks synergies in the
framework of the CCESE and with other Competence Centers at UMa. As a result,
based on CQM expertise in the field of nanomaterials, a new Master degree
program started in 2012/2013 (Master’s in Nanochemistry and Nanomaterials)
which was approved by the A3ES (Agency for Assessment and Accreditation of
Higher Education). This master course enrolled students from Portugal, China, and
India.
CQM’s evolution can be summarized by the following Facts and Figures for the period
of 2007-2012:





Number of PhDs: 2007 (15); 2008 (17); 2009 (18); 2010 (19); 2011 (20); 2012
(17);
Number of PhD students: 2007 (8); 2008 (9); 2009 (9); 2010 (10); 2011 (8);
2012 (9);
Number of Master students: 2007 (0); 2008 (5); 2009 (4); 2010 (10); 2011 (10);
2012 (7);
Publications with IF (127): 2007 (14); 2008 (12); 2009 (15); 2010 (15); 2011
(28); 2012 (43);
Average IF: 2007 (2.8); 2008 (3.0); 2009 (3.0); 2010 (3.9); 2011 (4.2); 2012
(4.6).
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A CTIVITIES
1. INTEGRATIVE/MULTIDISCIPLINARY ACTIVITIES DURING THE YEAR OF 2012
As a relatively small unit, the contact between both research groups is easy, promoted
and fundamental for the growth and consolidation of our research center. During 2012, the
CQM members from the Materials Group and the Natural Products Group have worked
together in:
a) Research projects such as the Project “VinSaudeMAC - Avaliação dos efeitos
biológicos de vinhos tintos na prevenção de patologias ateroscleróticas,
oncológicas e neurológicas”, funded by Interreg IIIB, which is headed by J. Câmara
(Natural Products Group) and also has the participation of H. Tomás (Materials
Group) in the animal cell culture experiments.
b) Science popularization activities (e.g. “Ocupação Científica de Jovens nas Férias/
Scientific occupation of young students during holiday time”, 1 week in July, and
“A Química é Divertida/Chemistry is Fun”, 1 week in November). All senior and
junior members of the CQM are engaged in these events. In 2012, CQM also
received several organized visits from highschool students.
c) The projects connected with the participation of CQM in the National NMR and
Mass Spectrometry networks. In the scope of the mentioned networks, one PhD
and a Master technicians were hired by CQM to work with the equipment and
support both research groups.
d) The management/sharing/maintenance of equipment and Lab spaces.
e) The supervision of periods of laboratory training for students of the 1st cycle in
Biochemistry offered by UMa; these periods of training (called “Estágios de Verão
no CQM”) occurred in July 2012; 5 students were enrolled in this training period.
2. OUTREACH ACTIVITIES DURING THE YEAR OF 2012
The current activities of CQM also include several initiatives that have the objective of
promoting and disseminating science amongst the general public, youngsters in particular.
The regular scientific outreach activities that were carried out by CQM in 2012 include:
a) “A Química é Divertida/Chemistry is Fun” (several chemistry related activities were
performed over the period of one week at the UMa labs,
http://cqm.uma.pt/quimicadivertida); in 2012 this activity also included “The Night
of Chemistry” which was held in Funchal downtown.
b) “Ocupação Científica de Jovens nas Férias/Scientific occupation of young students
during holiday time” (participation of 16 high school students over the period of
one week) which was supported by the Agência Nacional para a Cultura Científica e
Tecnológica (ANCCT) - Ciência Viva (€ 1540).
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c) “Estágios de Verão no CQM/Periods of training at CQM during the holidays”
(participation of 10 undergraduate students over the month of July); the students
had the opportunity to become familiar with the routine of lab research, learn new
techniques, gain new skills and develop new attitudes to overcome common and
advanced research problems. In addition, the students had the possibility to learn
more about the research performed at CQM.
d) Visits from schools (we had around 125 high school student visitors in 2012, within
“Chemistry is Fun”).
Our privileged way to disseminate CQM’s activities is through our website
(http://cqm.uma.pt), in English and Portuguese. We also make use of Twitter
(http://twitter.com/UMa_CQM; in December 2012 we were followed by 200 persons or
organizations, mainly from academia) and Facebook (http://on.fb.me/GCe7kN; followed by
350 “friends”). Furthermore, we have a regular press release service, a CQM flyer and a Facts
and Figures report (continuously updated) to be distributed during the events organized by
CQM.
CQM also often makes the news in the regional and national media. In 2012, ca. 78
short articles (interviews in newspapers and in specialized scientific websites) and TV news
were published. The regional TV channel usually covers all our activities (conferences, science
popularization actions, etc.). Overall, in 2012, CQM´s activities obtained a total estimated time
of 9 min on prime time news on the Regional TV station. Some CQM members were also
interviewed for the program “O Pátio dos Estudantes” (produced by the Student Union for the
regional TV station) and for the Student Union’s magazine.
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S CIENTIFIC R EPORT OF THE M ATERIALS G ROUP
GROUP DESCRIPTION
 Research Group Title: (RG-Madeira-674-390) - Materials Group
 Principal Investigator: Helena Maria Pires Gaspar Tomás
 Research Area: Chemistry
 Home Institution: Universidade da Madeira
FUNDING, SOURCE(S), DATES
Total funds allocated to the group in 2012 | €223.675
Secured funding for 2013| €227.814
Ongoing Projects and Grants headed by the Group (FCT-IP funded):
 €168.100 (€168.100 for CQM): PTDC/CTM/098451/2008. 2010-2013; PI: João
Rodrigues (OPUSGRAFT- Oligo(phenylene ethynylene)s Derivatives Covalently
Grafted Onto Porous Silicon: Novel Hybrid Molecular/semiconductor Systems for
Application as Waveguides)
 €151.251 (€80.193 for CQM): PTDC/CTM-NAN/112428/2009. 2011-2014. PI:
Helena Tomás (DENDRIMAT – New materials for drug/gene delivery based on
the self-assembly of dendrimer-chitosan-single stranded DNA)
 €156.808 (€156.808 for CQM): FCT funded. PTDC/CTM-NAN/116788/2010.
2012-2015. PI: Yulin Li (SELFNANO - Self-assembled Nanoparticles based on
PEG-PLA-dendrimer building blocks for dual gene/drug delivery)
 €47.040 (PhD grant): SFRH/BD/82361/2011. 2012-2015 (Freddy Rodrigues)
 €47.040 (PhD grants): SFRH/BD/265036/2009. 2010-2014 (Manuel Jardim)
 €53.820 (Post-Doc grant): SFRH/BPD/47369/2008. 2009-2012 (A. Nouri)
 €53.820 (Post-Doc grant): SFRH/BPD/75420/2010. 2011-2014 (S. Xiao)
Ongoing Projects with the participation of the Materials Group:
 €780.000 (€100.000 for CQM): INTERREG IIIB funded. BIOPHARMACMAC/1/M104. 2009-2012; Participant: Miguel Fernandes (Estratégias para o
desenvolvimento da Biotecnologia na Macaronésia)
 €168.200 (€8.000 for CQM): FCT funded. PTDC/SAUFAR/110848/2009. 20112013; Participant: Miguel Fernandes (Estudos funcionais, moleculares e
farmacológicos das proteínas da família p53: da levedura às células humanas)
17
 €157.193 (€4.730 for CQM): FCT funded. PTDC/QUI-QUI/099815/2008. 20102012; Participant: Miguel Fernandes (Diterpenos como protótipos na reversão
da multirresistência em células tumorais: moduladores da glicoproteína-P e
agentes antiproliferativos)
Projects and grants to be started in 2013:



€197.616 (€197.616 for CQM): FCT funded. PTDC/CTM-NAN/1748/2012. 20132015; PI: Xiangyang Shi (DENDIMAGE - Development of Novel Dendrimer-Based
Nanoparticles for Dual Mode Computed Tomography and Magnetic Resonance)
€47.040 (PhD grant): SFRH/BD/87465/2012. 2013-2016 (Rita Castro)
€47.040 (PhD grant): SFRH/BD/88721/2012. 2013-2016 (Mara Gonçalves)
OBJECTIVES AND ACHIEVEMENTS
Objectives
For 2012 and the coming years, the group established as its main objective to focus on
research in the field of new materials (in particular, molecular and nanomaterials) that are
designed and produced with specific applications in mind, namely in the areas of
nanomedicine and optoelectronics. Taking advantage of a team of researchers with
complementary expertise and concurrent interests (capable of connecting theory,
computation and experimental work in a cohesive manner), the idea is to launch projects
addressing outstanding scientific questions and technological issues, with clear objectives and
an applied focus. In this scope, the objectives include the conception of new materials,
processes and software related to the applications envisaged, as well as the understanding of
the chemical foundations of those materials and processes. The group aims to critically
question results and propose innovative ways to solve problems, to perform the highest
quality research in an ethically responsible manner, to communicate findings to laypeople and
experts and to promote the transfer of knowledge and technology.
In relation to the mentioned scientific objectives, the group established for 2012 and
subsequent years the following measurable goals:
 To enhance the scientific output of the team, i.e., the number of publications (in
international peer-reviewed journals) and their impact factor;
 To increase the number of researchers (namely, Post-Doc, Master and PhD
students);
 To obtain more funding (from national and European sources), especially to
acquire scientific equipment necessary for the characterization of materials,
particularly nanomaterials;
 To strengthen the internationalization of the team by launching new
collaborative projects with institutions and universities abroad, by
organizing/co-organizing scientific meetings, workshops and schools and by
integrating the team into international scientific networks.
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Main Achievements
In 2012, the group constituted 30 members. It consisted of 11 PhDs (8 members from
the host institution and 3 Post-Doc researchers), 4 PhD students, 3 Master Students, 8
researchers holding a Master’s degree and 4 other researchers. Two students from Donghua
University (China) also worked at the Materials Group in the scope of collaborative projects
(Shige Wang, PhD student, and Huihui Liao, researcher with a master degree) in 2012.
In 2012, the main achievements of the Materials Group can be summarized as follows:
a) During 2012, the group published 27 papers in journals with impact factor (the
average impact factor was 5.083 (IF 2011)); 1 of the papers was published in the
journal Chem. Soc. Rev. which has an impact factor of 26.583; 10 other papers were
accepted for publication; and plus 12 papers were submitted; in 2012, 1 paper was
also published in international journals still without impact factor but with peer
review, as well as 1 international proceeding;
b) The group presented a total of 23 oral presentations in scientific meetings (7 in
international meetings) and 13 poster presentations (13 in international meetings);
c) Based on the knowhow already existent at CQM in the field of nanomaterials, the
members of the Materials Group actively participated in the Master course on
“Nanochemistry and Nanomaterials” which was approved by A3ES (Agency for
Assessment and Accreditation of Higher Education) and started in September 2012
at the University of Madeira; this program will allow for the future enrolment of
more students in nanomaterials research;
d) A Gel Permeation Chromatography equipment was acquired in the scope of an
approved FCT project;
e) Daniel Lima, Carla Miguel, Paulo Craveiro and Cláudia Camacho concluded their
Master’s degrees, whereas the Master’s degree work of Marisol Gouveia, Fátima
Gouveia and Dina Maciel is still ongoing;
f) A new FCT funded research project was initiated in 2012 (PTDC/CTMNAN/116788/2010), as well as a PhD grant (SFRH/BD/82361/2011: 2012-2015 ,
Freddy Rodrigues);
g) Through Helena Tomás, the Materials Group integrated the COST Action TD0802 –
Dendrimers in Biomedical Applications (since 07/02/2011);
h) New funds for research were obtained by the group correspondent to 1 FCT funded
research
project
(PTDC/CTM-NAN/1748/2012)
and
2
PhD
Grants
(SFRH/BD/87465/2012, Rita Castro, and SFRH/BD/88721/2012, Mara Gonçalves) to
be started in 2013.
DISTINCTIONS, AWARDS AND MERITS
 Miguel Xavier Fernandes is, since the middle of 2009, Vice-Rector of the
University of Madeira.
 Xiangyang Shi is an editorial board member of the journal “ISRN Spectroscopy”
(since 2011).
19

João Rodrigues was is an editorial board member for the following journals:
International Journal of Materials and Chemistry (since 2011), The Scientific
World Journal (since 2012, IF 1.730) and of the Mediterranean Journal of
Chemistry.
 Helena Tomás was a member of the Scientific Committee of the 7th
International Meeting of the Portuguese Society for Stem Cells and Cellular
Therapy; Porto, Portugal; 26-27 April, 2012.
 João Rodrigues belongs, since 2008, to the National Technical Advisory Team
of the 7th Framework Program (FP7) – Cooperation Theme 4: Nanosciences,
Nanotechnologies, Materials, and New Production Technologies (NMP) from the
Gabinete de Promoção do 7º Programa-Quadro de I&DT.
 João Rodrigues is, since November 2009, the representative member of CQM
at the Scientific Board of the Centre of Competence in Exact Sciences and
Engineering.
 João Rodrigues is consultant of the Deutscher Technologiedienst GmbHinternational network and a “i-techpartner's” member (www.i-techpartner.eu),
a collaborative innovation network.
 João Rodrigues is member of Regional Board responsible for the roadmap for
Health in the framework of “Horizonte 2020” at Madeira Island.
GROUP PRODUCTIVITY
Published Articles in Peer-Reviewed Journals (IF of 2011)
12.1. Alves C.S.; Kairys V.; Castanho M.A.R.B.; Fernandes M.X.; Interaction of antimicrobial
peptides, BP100 and pepR, with model membrane systems as explored by Brownian
dynamics simulations on a coarse‐grained model; Biopolymers: Peptide Sc. 2012, 98, 298312. DOI: 10.1002/bip.22075.(IF: 2.87) http://cqm.uma.pt/CQM12/12-1_Biopolymers
Peptide_Sc.pdf
12.2. Cai H.; Kangan Li; Mingwu S.; Shihui W.; Yu L.; Chen P.; Guixiang Z., Shi X.; Facile
assembly of Fe3O4@Au core-shell nanoparticles for dual mode magnetic resonance and
computed tomography imaging applications. J. Mater. Chem. 2012, 22, 15110-15120. (IF:
5.968) http://cqm.uma.pt/CQM12/12-2_J Mater_Chem.pdf
12.3. Cao X.; Mingwu S.; Xiaodong Z.; Jun H.; Jianhua W.; Shi X.; Effect of the surface
functional groups of dendrimer-entrapped gold nanoparticles on the improvement of
polymerase chain reaction. Electrophoresis 2012, 33, 2598-2603.(IF: 3.303)
http://cqm.uma.pt/CQM12/12-4_Electrophoresis_.pdf
12.4. Chen J.; Xueyan C.; Rui G.; Mingwu S.; Chen P.; Tongyu X; Shi X.; A highly effective
polymerase chain reaction enhancer based on dendrimer-entrapped gold nanoparticles.
Analyst 2012, 137, 223-228. (IF: 4.230) http://cqm.uma.pt/CQM12/12-6_Analyst_.pdf
20
12.5. Fernandes C.; Tiritan M.E.; Cass Q.; Kairys V.; Fernandes M.X.; Pinto M.;
Enantioseparation and chiral recognition mechanism of new chiral derivatives of
xanthones on macrocyclic antibiotic stationary phases; J. Chromatogr. A. 2012, 1241, 6068. (IF: 4.531) http://cqm.uma.pt/CQM12/12-3_J Chromatogr_A.pdf
12.6.
Gonçalves M.; Castro R.; Rodrigues J.; Tomás H.; The Effect of PAMAM
Dendrimers on Mesenchymal Stem Cell Viability and Differentiation; Curr Med Chem 2012,
19,
4969-4975;
DOI:
10.2174/0929867311209024969.
(IF:
4.859)
http://cqm.uma.pt/CQM12/12-10_Curr Med Chem_.pdf
12.7.
Guo, R.; Shi, X.; Dendrimers in Cancer Therapeutics and Diagnosis; Current Drug
Metabolism 2012, 13, (8), 1097-1109; DOI: 10.2174/138920012802850010 (IF: 5.113)
http://cqm.uma.pt/CQM12/12-14_Current Drug Metabolism_.pdf
12.8. Huang Y.; Hui M.; Shige W.; Mingwu S.; Rui G.; Xueyan C.; Shi X.; Efficient catalytic
reduction of hexavalent chromium using palladium nanoparticle-immobilized electrospun
polymer nanofibers. ACS Appl. Mater. Interfaces 2012, 4(6), 3054-3061. (IF: 4.525)
http://cqm.uma.pt/CQM12/12-15_ACS_.pdf
12.9. Li Y.; Rodrigues J.; Tomás H.; Injectable and biodegradable hydrogels: gelation,
biodegradation and biomedical applications; Chem. Soc. Rev., 2012, 41, 199-2221. DOI:
10.1039/C1CS15203C.(IF: 28.760) http://cqm.uma.pt/CQM12/12-16_Chem Soc Rev_.pdf
12.10. Liu H.; Kai S.; Jinglong Z.; Mingwu S.; Guixiang Z.; Shi X.; Dendrimer-mediated synthesis
and shape evolution of gold-silver alloy nanoparticles. Colloids Surf. A-Physicochem. Eng.
Aspects 2012, 405, 22-29. (IF: 2.236) http://cqm.uma.pt/CQM12/12-17_Colloids Surf APhysicochem Eng Aspects_.pdf
12.11. Liu H.; Mingwu S.; Jinglong Z.; Rui G.; Xueyan C.; Guixiang Z.; Shi X.; Tunable synthesis
and acetylation of dendrimer-entrapped or dendrimer-stabilized gold-silver alloy
nanoparticles. Colloids Surf. B: Biointerfaces 2012, 94, 58-67.
(IF:
3.456)
http://cqm.uma.pt/CQM12/12-18_Colloids Surf B Biointerfaces_.pdf
12.12. Ma H.; Mingwu S.; Rui G.; Xueyan C.; Shi X.; Enhanced dechlorination of
trichloroethylene using electrospun polymer nanofibrous mats immobilized with
iron/palladium bimetallic nanoparticles. J. Hazard. Mater. 2012, 211-212, 349-356.(IF:
4.173) http://cqm.uma.pt/CQM12/12-19_J Hazard Mater_.pdf
12.13. Nouri A.; Castro, R.; Kairys, V.; Santos, J. L.; Rodrigues J.; Li, Y.; Tomás H.; Insight into
the role of N, N-dimethylaminoethyl methacrylate (DMAEMA) conjugation onto poly
(ethylenimine): cell viability and gene transfection studies, J. Mater Sci: Mater. M., 2012,
23,
2967-2980.
DOI:
10.1007/s10856-012-4753-9.(IF:
2.316)
http://cqm.uma.pt/CQM12/12-21_J Mater Sci Mater Med_.pdf
12.14. Nouri A.; Castro R.; Santos J.L.; Fernandes C.; Rodrigues J.; Tomás H.; Calcium
phosphate-mediated gene delivery using simulated body fluid (SBF); Int. J.Pharma., 2012,
434, 199-208. (IF: 3.350) http://cqm.uma.pt/CQM12/12-23_Int_J_Pharma_.pdf
12.15. Palmeira A.; Sousa E.; Fernandes M.X.; Pinto M.M.; Vasconcelos M.H.; Multidrug
resistance reversal effects of aminated thioxanthones and interaction with cytochrome
21
P450 3A4;
J. Pharm. Pharm. Sci.,
2012,
15,
http://cqm.uma.pt/CQM12/12-24_J Pharm Pharm Sci_.pdf
31-45.
(IF:
1.646)
12.16.
Palmeira A.; Sousa E.; Vasconcelos M.H.; Pinto M.M.; Fernandes M.X. Structure
and Ligand-based Design of P-glycoprotein Inhibitors: A Historical Perspective. Curr Pharm
Des. 2012, 18: 4197-4214. DOI: 10.2174/138161212802430530 (IF: 3.870)
http://cqm.uma.pt/CQM12/12-24_Current Pharmaceutical Design_.pdf
12.17. Palmeira A.; Vasconcelos M.H.; Paiva A.; Fernandes M.X.; Pinto M.; Sousa E.; Dual
inhibitors of P-glycoprotein and tumor cell growth: (re)discovering thioxanthones; Biochem
Pharmacol., 2012, 83, 57-68.
(IF: 4.705) http://cqm.uma.pt/CQM12/12-25_Biochem
Pharmacol_.pdf
12.18.
Peng, C.; Li, K.; Cao, X.; Xiao, T.; Hon, W.; Zheng, L.; Guo, R.; Shen, M.; Zhang, G.;
Shi, X.; Facile formation of dendrimer-stabilized gold nanoparticles modified with diatrizoic
acid for enhanced computed tomography imaging applications; Nanoscale 2012, 4, (21),
6768-6778; DOI: 10.1039/c2nr31687k(IF: 5.914) http://cqm.uma.pt/CQM12/1226_Nanoscale_.pdf
12.19. Peng, C.; Zheng, L.; Chen, Q.; Shen, M.; Guo, R.; Wang, H.; Cao, X.; Zhang, G.; Shi, X.;
PEGylated dendrimer-entrapped gold nanoparticles for in vivo blood pool and tumor
imaging by computed tomography; Biomaterials 2012, 33, (4), 1107-1119; DOI:
10.1016/j.biomaterials.2011.10.052.
(IF:
7.404)
http://cqm.uma.pt/CQM12/1227_Biomaterials_.pdf
12.20.
Santos J.L.; Nouri A.; Fernandes T.; Rodrigues J.; Tomás H.; Gene delivery using
biodegradable polyelectrolyte microcapsules prepared using the layer-by-layer technique;
Biotechnol. Prog., 2012, 28, 1088-1094. (IF: 2.34) http://cqm.uma.pt/CQM12/1231_Biotechnol. Prog.pdf
12.21. Shan Y.; Luo T.; Peng C.; Sheng R.; Cao A.; Cao X.; Shen M.; Guo R.; Tomás H.; Shi X.;
Gene delivery using dendrimer-entrapped gold nanoparticles as nonviral vectors;
Biomaterials, 2012, 33, 3025-3035. (IF: 7.404) http://cqm.uma.pt/CQM12/1233_Biomaterials_.pdf
12.22. Shen M.; Hongdong C.; Xifu W.; Xueyan C.; Kangan L.; Su He W.; Rui G.; Linfeng Z.;
Guixiang Z.; Shi X.; Facile one-pot preparation, surface functionalization, and toxicity assay
of APTS-coated iron oxide nanoparticles. Nanotechnology 2012, 23, 105601. (IF: 3.979)
http://cqm.uma.pt/CQM12/12-33_Nanotechnology_.pdf
12.23. Sousa I. J.; Ferreira M. J. U.; Molnár J., Fernandes M. X.; QSAR studies of macrocyclic
diterpenes with P-glycoprotein inhibitory activity; Eur J Pharm Sci 2012, 48:542-553; DOI:
10.1016/j.ejps.2012.11.012 (IF: 3.212) http://cqm.uma.pt/CQM12/12-43_European
Journal_of_Pharmaceutical Sciences.pdf
12.24. Tong, W.; Cao, X.; Wen, S.; Guo, R.; Shen, M.; Wang, J.; Shi, X.; Enhancing the specificity
and efficiency of polymerase chain reaction using polyethyleneimine-based derivatives
and hybrid nanocomposites; Int. J. Nanomed. 2012, 7, 1069-1078; DOI:
10.2147/IJN.S28947 (IF: 3.130) http://cqm.uma.pt/CQM12/12-38_Int J Nanomed_.pdf
22
12.25.
Wang S.; Castro R.; Song C.; Luo Y.; Shen M.; Tomás H.; Zhu M.; Shi X.; Electrospun
laponite-doped poly(lactic-co-glycolic acid) nanofibers for osteogenic differentiation of
human mesenchymal stem cells; J. Mater. Chem., 2012, 22, 23357-23367; DOI:
10.1039/C2JM34249A. (IF: 5.97) http://cqm.uma.pt/CQM12/12-39_J Mater Chem_.pdf
12.26.
Wang, S.; Cao, X.; Shen, M.; Guo, R.; Banyai, I.; Shi, X.; Fabrication and morphology
control of electrospun poly(gamma-glutamic acid) nanofibers for biomedical applications;
Colloids
and
Surfaces
B-Biointerfaces
2012,
89,
254-264;
DOI:
10.1016/j.colsurfb.2011.09.029. (IF: 3.456) http://cqm.uma.pt/CQM12/12-40_Colloids
and Surfaces B-Biointerfaces_.pdf
12.27. Wang, S.; Zheng, F.; Huang, Y.; Fang, Y.; Shen, M.; Zhu, M.; Shi, X.; Encapsulation of
Amoxicillin within Laponite-Doped Poly(lactic-co-glycolic acid) Nanofibers: Preparation,
Characterization, and Antibacterial Activity; ACS Appl. Mater. Interfaces 2012, 4, 63936401; DOI: 10.1021/am302130b. (IF: 4.525) http://cqm.uma.pt/CQM12/12-41_ACS_.pdf
Proceedings With Peer Review
PR12.1. Li Y.; Shan Y.; Tomás H.; Shi. X.; Rodrigues J. Laponite/alginate hydrogels for release
of doxorubicin - an injectable pH sensitive hybrid material. Eur. Cells Mater, 2012, 23
Suppl.
3,
44.
(IF:
9.650)
http://cqm.uma.pt/CQM12/12European_Cells_and_Materials_23_Suppl_3_44_.pdf
Published Papers in International Journals With Peer Review But Without Impact
Factor
WF12.1.
Wang S., Yili Zhao, Mingwu Shen, Xiangyang Shi. Electrospun hybrid
nanofibers doped with nanoparticles or nanotubes for biomedical applications.
Therapeutic Delivery 2012, 10:1155-69 (invited review); DOI: 10.4155/tde.12.103.
Accepted Papers in Peer-Reviewed Journals
AP12.1.Figueira J., Jardim M. G., Rodrigues J., Valkonen A., Rissanen K.; A convenient route for
the preparation of the monohydride catalyst trans-[RuCl(H)(dppe)2] (dppe =
Ph2PCH2CH2PPh2): Improved Synthesis and Crystal Structure; Inorg. Chem. Commun. (IF:
1.972).
AP12.2. Liu H., Yanhong Xu, Shihui Wen, Jingyi Zhu, Linfeng Zheng, Mingwu Shen, Jinglong
Zhao, Guixiang Zhang and Xiangyang Shi. Facile hydrothermal synthesis of low generation
dendrimer-stabilized gold nanoparticles for in vivo computed tomography imaging
applications. Polym. Chem. 2013, DOI:10.1039/C2PY20993D (IF: 5.321).
AP12.3. Luo, Y.; Wang, S.; Shen, M.; Qi, R.; Fang, Y.; Guo, R.; Cai, H.; Cao, X.; Tomás, H.; Zhu,
M.; Shi, X.; Carbon nanotube-incorporated multilayered cellulose acetate nanofibers for
tissue engineering applications; Carbohydrate Polymers 2013, 91, 419-427; DOI:
10.1016/j.carbpol.2012.08.069 (IF: 3.628).
23
AP12.4. Maiti S. K., Jardim M. G., Rodrigues J., Rissanen K., Campo J. and Wenseleers W.;
Divergent Route to the Preparation of Hybrid Pt-Fe 2,4,6-Tris(4-ethynyl)phenyl-1,3,5triazine
Metallodendrimers
for
Nonlinear
Optics;
Organometallics,
DOI:
10.1021/om300745v. (IF: 3.963).
AP12.5. Sousa I. J.; Padrón J. M.; Fernandes M. X.; Generation of Artificial Neural Networks
Models in Anticancer Study; Neural Computing and Applications 2012 (IF: 0.699).
AP12.6. Wen S., Fuyin Zheng, Mingwu Shen, Xiangyang Shi. Surface modification and
PEGylation of branched polyethyleneimine for improved biocompatibility. J. Appl. Polym.
Sci. 2012 (IF: 1.289).
AP12.7. Wen, S.; Li, K.; Cai, H.; Chen, Q.; Shen, M.; Huang, Y.; Peng, C.; Hou, W.; Zhu, M.;
Zhang, G.; Shi, X.; Multifunctional dendrimer-entrapped gold nanoparticles for dual mode
CT/MR
imaging
applications;
Biomaterials
2013,
34,
1570-1580;
doi:
10.1016/j.biomaterials.2012.11.010 (IF: 7.404).
AP12.8. Wen, S.; Zheng, F.; Shen, M.; Shi, X.; Synthesis of polyethyleneimine-stabilized gold
nanoparticles for colorimetric sensing of heparin; Colloids and Surfaces A: Physicochemical
and Engineering Aspects 2013, 419, 80-86; doi: 10.1016/j.colsurfa.2012.11.052 (IF: 2.236).
AP12.9. Zheng F., Shige Wang, Mingwu Shen, Meifang Zhu, Xiangyang Shi. Antitumor efficacy
of doxorubicin-loaded electrospun nano-hydroxyapatite/poly(lactic-co-glycolic acid)
composite nanofibers. Polym. Chem. 2013, DOI:10.1039/C2PY20779F (IF: 5.321).
AP12.10. Zheng, F.; Wang, S.; Wen, S.; Shen, M.; Zhu, M.; Shi, X.; Characterization and
antibacterial activity of amoxicillin-loaded electrospun nano-hydroxyapatite/poly(lactic-coglycolic acid) composite nanofibers; Biomaterials 2013, 34, (4), 1402-1412; doi:
10.1016/j.biomaterials.2012.10.071 (IF: 7.404).
Submitted Papers to Peer Review Journals
SP12.1. Alves C. S.; Kairys V.; Castanho M. A. R. B.; Fernandes, M. X.; Conformational and
dynamic properties of the cell-penetrating peptide, Pep-1, in model membrane systems:
Brownian dynamics simulations on a coarse-grained model;
SP12.2. Cai H, Xiao An, Jun Cui, Jingchao Li, Shihui Wen, Kangan Li, Mingwu Shen, Linfeng
Zheng, Guixiang Zhang, Xiangyang Shi. Facile Hydrothermal Synthesis and Surface
Functionalization of Polyethyleneimine-Coated Iron Oxide Nanoparticles for Biomedical
Applications;
SP12.3. Tavares H. S., Santos J.L., de Oliveira P.T., Tomás H., Guastaldi A.C.; Human
mesenchymal stem cells differentiation on nanostructured titanium surfaces obtained by
Yb:YAG laser irradiation;
SP12.4. Liu H, Mingwu Shen, Jinglong Zhao, Jingyi Zhu, Tingting Xiao, Xueyan Cao, Guixiang
Zhang, and Xiangyang Shi. Folic Acid-Targeted Dendrimer-Stabilized Gold-Silver Alloy
Nanoparticles: Formation, Characterization, and Potential Cellular Computed Tomography
Imaging Applications;
24
SP12.5. Liu H., Mingwu Shen, Jinglong Zhao, Jingyi Zhu, Tingting Xiao, Xueyan Cao, Guixiang
Zhang, and Xiangyang Shi. Facile formation of folic acid-modified dendrimer-stabilized
gold-silver alloy nanoparticles for potential cellular computed tomography imaging
applications;
SP12.6. Liu H., Yanhong Xu, Shihui Wen, Qian Chen, Linfeng Zheng, Mingwu Shen, Jinglong
Zhao, Guixiang Zhang, and Xiangyang Shi. Targeted Tumor Computed Tomography
Imaging Using Low Generation Dendrimer-Stabilized Gold Nanoparticles;
SP12.7. Ma H, Yunpeng Huang, Mingwu Shen, Meifang Zhu, Xiangyang Shi. Enhanced
decoloration efficacy of electrospun polymer nanofibers immobilized with Fe/Ni bimetallic
nanoparticles;
SP12.8. Qi R., Rui Guo, Fuyin Zheng, Hui Liu, Jianyong Yu, Xiangyang Shi. Controlled release
and antibacterial activity of antibiotic-loaded electrospun halloysite/ poly(lactic-co-glycolic
acid) composite nanofibers;
SP12.9. Wang H, Linfeng Zheng, Chen Peng, Mingwu Shen, Xiangyang Shi, Guixiang Zhang.
Folic acid-modified dendrimer-entrapped gold nanoparticles as nanoprobes for targeted
CT imaging of human lung adenocarcinoma;
SP12.10. Wang S., Yilun Wu, Rui Guo, Yunpeng Huang, Shihui Wen, Mingwu Shen, Jianhua
Wang, Xiangyang Shi. Laponite nanodisks as an efficient platform for doxorubicin delivery
to cancer cells;
SP12.11. Wen S., Hui Liu, Hongdong Cai, Mingwu Shen, Xiangyang Shi. Targeted and pHResponsive Delivery of Doxorubicin to Cancer Cells Using Multifunctional DendrimerModified Multi-Walled Carbon Nanotubes;
SP12.12. Xiao T., Shihui Wen, Hui Liu, Mingwu Shen, Jinglong Zhao, Guixiang Zhang, Xiangyang
Shi. Facile synthesis of acetylated dendrimer-entrapped gold nanoparticles with enhanced
gold loading.
Thesis
TH12.1.Camacho, C. S.; Polímeros Condutores em Monocamadas Automontadas para a
Determinação de Compostos de Interesse Ambiental, thesis presented to obtain the MSc
degree in Applied Biochemistry, Universidade da Madeira, 2012.
TH12.2.Craveiro P. A. G. N.; Deposição por Jato de Tinta de Materiais Funcionais com
Aplicação em Bioquímica, thesis presented to obtain the MSc degree in Applied
Biochemistry, Universidade da Madeira, 2012.
TH12.3.Lima, D.B.; Interação das Células Estaminais Mesenquimais com um Novo Material de
Implante à Base de Hidroxiapatite com Multicamadas de Polielétrolitos, thesis presented
to obtain the MSc degree in Applied Biochemistry, Universidade da Madeira, 2012.
TH12.4.Miguel, C. S. C.; Síntese e Caracterização de Nanopartículas FeOx/Au/Ag em
Multicamada Núcleo-concha, thesis presented to obtain the MSc degree in Applied
Biochemistry, Universidade da Madeira, 2012.
25
Abstracts in International Scientific Meetings
- Oral Communications
OCI12.1.
Li Y., Gonçalves M., Figueira P., Maciel D., Rodrigues J., Tomás H.; pH
Sensitive Laponite/Alginate Nanogels for Release of Doxorubicin; International Symposium
on Nanomaterials and Nanodevices; Suzhou, China; September 12-5, pages: 44-45, 2012.
OCI12.2.
Rodrigues J., Jardim M., Figueira J., Gouveia M., Tomás H., Rissanen K.; Lowgeneration ruthenium based metallodendrimers for biomedical applications;
Biodendrimers 2012 – 3rd International Symposium on Biological Applications of
dendrimers, September 5-8, Toledo, Spain, OC5, Page 39, 2012.
OCI12.3.
Peng C., Liu H., Cai H.D., Guo R., Shen M.W., Cao X.Y., Shi X. Y. Dendrimerbased organic/inorganic hybrid nanoparticles for molecular imaging applications. SinoGerman Symposium on Functional Organic/Inorganic Hybrid Materials, May 29-June 3,
2012, Shanghai (invited lecture).
OCI12.4.
Shi X, Shihui Wen, Kangan Li, Guixiang Zhang. Multifunctional Dendrimerbased Nanoparticles for Dual Mode CT/MRI Molecular Imaging. 9 World Biomaterials
Congress, June 1-5, 2012, Chengdu, China.
OCI12.5.
Ting-ting X, PENG Chen, LIU Hui, GUO Rui, SHI Xiangyang. Diatrizoic acidmodified dendrimer-stabilized gold nanoparticles for enhanced CT imaging applications.
2012 International Forum on Biomedical Textile Materials, Donghua University, Songjiang
Campus, Shanghai, P.R. China, June 8-9, 2012.
OCI12.6.
Jardim M.G., Rodrigues J., Mesquita J.C., Rissanen K.; Campo J., Wenseleers
W.; Synthesis and electrochemical characterization of novel octupolar metallodendrimers;
XIV Iberic Meeting of Electrochemistry & XVII Meeting of the Portuguese Electrochemical
Society; Funchal, Portugal; 11-14 Abril, OC16, 2012.
OCI12.7.
Rodrigues J., Jardim M. G., Gouveia M., Figueira J., Tomás H., Rissanen K.;
Ruthenium poly(alkylidenamine) nitrile dendrimers - a new family of
biometallodendrimers; XXV International Conference on Organometallic Chemistry (XXV
ICOMC), September 2-7, Lisbon, OCS3.6, Page 42, 2012 (invited lecture).
INVITED SEMINARS AT OTHER UNIVERSITIES
Rodrigues J.; 2,4,6-tri-substituted-1,3,5-triazine core derivatives as building blocks for
the preparation of heterometallodendrimers for non-linear optical applications; Southeast
University, March 27, Nanjing, P.R. China, 2012.
Rodrigues J.; Novel Octupolar Metallodendrimers base on two 1,3,5-triazine core
derivatives, the 2,4,6-tris(((4-ethynylphenyl)ethynyl)phenyl)-1,3,5-triazine (TET) and 2,4,6tris(4-ethynylphenyl)-1,3,5-triazine (TEPT); Donghua University, April 1, Shanghai, P. R. China,
2012.
Tomás H.; Dendrimers and mesenchymal stem cells; Donghua University, Shanghai,
China, 2012.
26
- Poster Communications
PCI12.1. Araújo HC, A Pimenta, M Barroso, I Rivera, R Castro, I Tavares de Almeida;
Homocysteine, folate and vitamin B12 in Portuguese children: Genetic determinants and
reference intervals; SSIEM International Symposium; Birmingham, 4-7 September, 2012.
PCI12.2. Castro R.; Santos J.L.; Rodrigues J.; Tomás H.; Antisense oligonucleotide delivery by
PAMAM dendrimers functionalized with hydrophobic chains; 3rd International Symposium
on Biological Application of Dendrimers; Toledo, Spain; 5-8 September, page 91, 2012.
PCI12.3. Fuyin Z, Wang Shige, Shen Mingwu, Shi Xiangyang. Antitumor efficacy of electrospun
n-HA/PLGA composite nanofibers encapsulated with doxorubicin. 2012 International
Forum on Biomedical Textile Materials, Donghua University, Songjiang Campus, Shanghai,
P.R. China, June 8-9, 2012.
PCI12.4. Gonçalves M., Castro R., Rodrigues J., Tomás H.; Effect of PAMAM Dendrimers with
Different Surface Functionalities on Mesenchymal Stem Cell Differentiation; 7th
International Meeting of the Portuguese Society for Stem Cells and Cellular Therapy Novel Frontiers in Stem Cell Research; Porto, Portugal; 26-27 April, page 73, 2012.
PCI12.5. Lahoz F., D. López, J. Figueira, J. C. Mesquita, N. Oliveira, J. Rodrigues, A. Valkonen,
K. Nättinen, K. Rissanen; Time resolved fluorescence characterization of oligo(pphenyleneethynylene) based metallic nanorods; Trends in Nanotechnology International
Conference (TNT2011), November 21-25, Tenerife, Canary Island, Spain, 2012.
PCI12.6. Hai-xia Z, CAO Xue-yan, PENG Chen, SHI Xiangyang. Effect of antifouling dendrimers
and dendrimer-entrapped gold nanoparticles on the improvement of polymerase chain
reactions. 2012 International Forum on Biomedical Textile Materials, Donghua University,
Songjiang Campus, Shanghai, P.R. China, June 8-9, 2012.
PCI12.7. Huixin J, Liu Hui, ShanHAN Yuebin, LuoUO Ting, Sheng Ruilong, Zheng Fuyin, Cao
Amin, Shi Xiangyang. Liver Cancer Cell Targeting Gene Delivery Using Lactobionic AcidFunctionalized Dendrimers as Nonviral Vectors. 2012 International Forum on Biomedical
Textile Materials, Donghua University, Songjiang Campus, Shanghai, P.R. China, June 8-9,
2012.
PCI12.8. Camacho C., Mesquita J.C., Rodrigues J.; Electrochemistry of polyaniline deposited
on graphite electrodes modified with self-assembled monolayers; XIV Iberic Meeting of
Electrochemistry & XVII Meeting of the Portuguese Electrochemical Society; Funchal,
Portugal; 11-14 Abril, PE5, 2012.
PCI12.9. Qian C, Wen Shihui, Peng Chen, Shi Xiangyang. Synthesis and characterization of
multifunctional dendrimer-based organic/inorganic hybrid nanoparticles for dual mode
CT/MR imaging applications. 2012 International Forum on Biomedical Textile Materials,
Donghua University, Songjiang Campus, Shanghai, P.R. China, June 8-9, 2012.
PCI12.10.
Shi X, Hongdong Cai, Kangan Li, ShihuiWen, Chen Peng, Mingwu Shen,
Guixiang Zhang. Fabrication of Fe3O4@Au Core-shell Nanoparticles via Layer-by-layer
27
Assembly for Dual Mode MR and CT Imaging Applications. 9 World Biomaterials Congress,
June 1-5, 2012, Chengdu, China.
PCI12.11.
Wang Sh, Xiangyang Shi, James R Baker, Jr. Iron Oxide Modified
Nanoemulsion, A Novel Mucosal Adjuvant. 9 World Biomaterials Congress, June 1-5, 2012,
Chengdu, China.
PCI12.12.
Figueira J., Mesquita J.C., Rissanen K., Rodrigues J.; Preparation and cyclic
voltammetry studies of Ru and Pd phenylene ethynylene and thiophenylene ethynylene
rods; XIV Iberic Meeting of Electrochemistry & XVII Meeting of the Portuguese
Electrochemical Society; Funchal, Portugal; 11-14 Abril, PF3, 2012.
PCI12.13. Oliveira, N., Figueira, J., Hui, F., Rodrigues, J., Mesquita, J.C., Rissanen, K., Lahoz, F.;
Oligo(phenylene ethynylene)s derivatives, for application as organic-inorganic hybrid
molecular/semiconductor waveguides; XXV International Conference on Organometallic
Chemistry, Lisbon, Portugal, 2 September, page F2.8, 2012.
Abstracts in National Scientific Meetings
OCN12.1.
Camacho C., Mesquita J.C., Rodrigues J.; Conditions for the
Electropolymerisation of Polyaniline on Graphite/Self‐Assembly Monolayer; 7th Materials
Group Meeting/CQM; Funchal, Portugal; 27 Janeiro, 2012.
OCN12.2. Castro R.; Rodrigues J.; Tomás H.; New Delivery Systems Based on Dendrimers with
Applications in Antisense Therapy; 7th Materials Line Meeting; Funchal, Portugal; 27
January, 2012.
OCN12.3. Figueira J, N. Oliveira, F. Hui, J. C. Mesquita, J. Rodrigues, F. Lahoz, K. Rissanen;
Organic-inorganic hybrid molecular/semiconductor waveguides based on oligo(phenylene
ethynylene)s derivatives, Workshop Nano12 - Shaping the Future, Academia das Ciências
de Lisboa, Lisboa, Portugal, 18 October 2012.
OCN12.4.
Figueira J., Mesquita J.C., Rodrigues J., Rissanen K., Lahoz F.; Synthesis, cyclic
voltammetry and time of life fluorescence studies of phenylene ethynylene based
ruthenium and palladium binuclear rods; 7th Materials Group Meeting/CQM; Funchal,
Portugal; 27 Janeiro, 2012.
OCN12.5.
Jardim M.G., Rodrigues J., Mesquita J.C., Rissanen K., Campo J., Wenseleers
W.; Synthesis and Characterization of Novel Octupolar Metallodendrimers; 7th Materials
Group Meeting/CQM; Funchal, Portugal; 27 Janeiro, 2012.
OCN12.6.
Liao H., Li Y.; Tomás H.; Rodrigues J.; Shi X. PEGylated-PAMAM dendrimers for
drug delivery. 7th Materials Group Meeting, Química da Madeira, the University of
Madeira; Funchal Portugal; 27 January, 2012.
OCN12.7.
Lima D., Rodrigues J., Fook M. V. L, Tomás H.; Evaluation of the viability,
proliferation and osteogenic differentiation of mesenchymal stem cells cultured on the
28
surface of a new implant material based on hydroxyapatite; 7th Materials Group
Meeting/CQM, January 27th, Funchal, Portugal, O7, 2012.
OCN12.8.
Marisol G., Tomás H., Rodrigues J.; Preparation of low-generation
metallodendrimers using nitrile-functionalized poly(alkylidenamines) dendrimers:
cytotoxicity studies in cancer cell lines; 7th Materials Group Meeting/CQM, January 27th,
Funchal, Portugal, O7, 2012.
OCN12.9.
Miguel C., Tomás H., Rodrigues J.; Synthesis and Characterization of
Multilayered core/shell Nanoparticles; 7th Materials Group Meeting/CQM, January 27th,
Funchal, Portugal, O9, 2012.
OCN12.10.
Oliveira N., J. Figueira, F. Hui, J. Mesquita, J. Rodrigues, K. Rissanen, F.
Lahoz,Preparation of oligo(phenylene ethynylene)s derivatives, for application as
waveguides; 7th Materials Group Meeting/CQM, 27th January 2012, Campus da Penteada,
9000-390 Funchal, Portugal, 2012.
OCN12.11. Pires P., Inkjet Printed Materials, Plenary lecture presented at the 7th Materials
Group Meeting/CQM; Funchal, Portugal; 27th January, 2012.
OCN12.12.
Rodrigues F., Fernandes M.X.; Application of the Pharmacophore Method to
the Diterpene Family; 7th Materials Group Meeting/CQM; Funchal, Portugal; 27th January,
2012.
OCN12.13. Rodrigues J.; Nonlinear optical materials and their applications, Physics 2012, 2829 of September, Ponta Delgada, Azores Island, Portugal, 2012.
OCN12.14.
Sousa I. J., Fernandes M. X.; Application of ANN to Cucurbitane-Type
Triterpenoids; 7th Materials Group Meeting/CQM, Funchal, Portugal; 27th January, 2012.
OCN12.15. Sousa I. J., Padrón J. M., Fernandes M. X.; Generation of Artificial Neural Networks
Models in Anticancer Study; 10th Portuguese Conference on Automatic Control CONTROLO’12; Funchal, Portugal; 16-18 Julho, page 152 , 2012.
OCN12.16. Nouri A., Castro R., Santos J. L., Fernandes C., Rodrigues J. Tomás H.,; Calcium‐
Phosphate Mediated Transfection Using Simulated Body Fluid (SBF); 7th Materials Group
Meeting/CQM, January 27th, Funchal, Portugal, O13, 2012.
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ORGANIZATION OF CONFERENCES
During the year of 2012 our group organized:
a) At the University of Madeira, the Nanoschool 2012, “Design, synthesis and
biofunctionalization of magnetic nanoparticles: current and prospective in vivo
applications” (15-19 October 2012). The lectures (8h) were presented by Prof.
29
Etienne Duguet, from the University of Bordeaux (France); the school had around
20 participants. The Materials Group organizes this event since 2008.
b) At the University of Madeira, the 7th Annual Meeting of the Materials Group (27th
January 2012), involving a total of 13 oral communications and a plenary lecture
(open to all academia/number of participants: 40).
c) The XIV Iberic Meeting of Electrochemistry & XVII Meeting of the Portuguese
Electrochemical Society (Chairman: João Rodrigues), number of participants: 63
from 13 countries. http://cqm.uma.pt/ime2012/.
INTERNATIONALIZATION
Beyond the national collaborations, the group has active collaborations (with joint
publications/ongoing scientific work) with:
 Donghua University, College of Chemistry, Chemical Engineering and
Biotechnology, China.
 Center for Advanced Research in Biotechnology, University of Maryland
Biotechnology Institute, USA.
 Dep. of Biochemistry and Molecular Pharmacology, University of Massachusetts
Medical School, USA.
 Dep. of Organic Chemistry, Faculty of Chemistry, Vilnius University, Lithuania.
 Dep. de Química Física, Facultad de Química, Universidad de Murcia, Spain.
 Forschungszentrum Karlsruhe GmbH, Institut fur Nanotechnologie, Karlsruhe,
Germany.
 Dep. of Physical Chemistry, University of Oslo, Oslo, Norway.
 Instituto Canario de Investigación del Cáncer, Spain.
 NanoScience Center, Dep. of Chemistry, University of Jyväskylä, Finland.
 Institut des Sciences Moléculaires, Univ. de Bordeaux I, France.
 Univ. of Antwerp, Belgium.
 Dep. de Física Fundamental y Experimental, Electrónica y Sistemas, Fac. de
Física, Univ. of La Laguna, Spain.
 Nanotube Research Center, National Inst. of Advanced Industrial Science and
Technology –AIST, Japan.
 Universidade Federal de Campina Grande, Centro de Ciências e Tecnologia,
Brazil.
The level of internationalization of the Materials Group in 2012 was also evidenced by
the following:
a) The group integrated the COST Action TD0802 - Dendrimers in Biomedical
Applications;
30
b) The group was organizer of a Nanoschool and several conferences with the
participation of foreign outstanding scientists, especially in the field of
Nanochemistry and Nanomaterials (already mentioned);
c) Prof. Xiangyang Shi is an Invited Full Professor at UMa (Chair in Nanotechnology,
with the support of the Santander Bank and FCT) and also a researcher at Donghua
University (China); the existence of this Chair in Nanotechnology is very important
for CQM and, in particular, for the Materials Group, since it reinforced the
knowledge in dendrimer chemistry at the group and, very importantly, allowed the
exchange of students between CQM and Donghua University (since 2010, CQM
regularly receives Chinese researchers for periods of training/research); Prof.
Xiangyang Shi is actively developing research work at CQM (he stays at UMa for
one entire semester during the year) and, as a result, an increasing number of
publications shared with other CQM members are being published with the
progress of time; Prof. Xiangyang Shi is also the principal investigator of an FCT
project which is going to start in 2013 (one researcher with a master degree and a
post-doc student will be hired through this project); furthermore, H. Tomás and J.
Rodrigues stayed at Donghua University for two weeks in 2012 to discuss results of
the ongoing research, make seminars and exploit the possibility of additional
collaborations with other Chinese professors;
d) The group received two PhD students from China for a period of research (Shige
Wang, PhD student, and Huihui Liao, researcher with a master degree) in the scope
of the Chair in Nanotechnology;
e) The group has PhD projects in collaboration with other international teams;
f) Pedro Pires was appointed as a National Expert assigned to the Unit of Micro and
Nanosystems of the DG Information Society (INFSO G2), European Commission,
Brussels, in 2006 (he returned in 2011);
g) João Rodrigues belongs, since 2008, to the evaluation panel of the COST Action
D35 - Molecular Devices (Switzerland Multilateral Research-Cooperation, Swiss
Confederation) and the evaluation panel of Information and Communication
Technologies (ICT) of the 7th FP (Small and medium scale focused research projects
(STREPs));
h) The members of the group belong to several international professional societies
and are referees of several journals with international circulation.
PROGRAMMED ACTIVITIES FOR 2013
 Organization of the 8th Edition of the annual Materials Group Meeting/CQM,
January 25th 2013.
 Organization of the 6th edition of the Nanoschool (the lecturer will be Professor
Serge Mignani from the University of Paris Descartes, France), October 2013.
31
32
S CIENTIFIC R EPORT OF THE N ATURAL P RODUCTS G ROUP
GROUP DESCRIPTION
 Research Group Title: (RG-Madeira-674-391) - Natural Products Group
 Principal Investigator: Paula Cristina Machado Ferreira Castilho
 Research Area: Chemistry
 Home Institution: Universidade da Madeira
FUNDING, SOURCE(S), DATES
Total funds allocated to the group in 2012 | €177.808
Ongoing Projects and Grants headed by the Group:
INTERREG IIIB funded:
 €617.541 (€271.000 for CQM): MAC/1/M105PI. 2009-2013; PI: José Câmara
(VinSaudeMAC - Evaluation of the bioactive effect of red wines in the prevention
of atheroschlerotic, oncologic and neurodegenerative diseases. Implementation of
vinification processes to optimise the antioxidant potential of red wines).
FCT-IP funded:
 €166.696 (€114.860 for CQM): PTDC/CTM-CER/121295/2010. 2012-2015; PI: Paula
Castilho (CLAYCATS4 - Clay catalysts for biomass conversion)
 €69.553 (€30.502 for CQM): PTDC/AGR-ALI/122261/2010. 2012-2014; Participant:
Paula Castilho (Desconstrução de Biomassa utilizando Super-ácidos Sólidos)
 €120.637 (€6.600 for CQM): PTDC/QUI-QUI/119116/2010. 2012-2015; Participant:
Paula Castilho (Ocean Treasures - Ocean sediments from Madeira Archipelago: a
new source of innovative and bioactive compounds)
 € 47.040 (PhD grant): SFRH/BD/38855/2007. 2008-2012 (Rosa Perestrelo)
 € 47.040 (PhD grant): SFRH/BD/40374/2007. 2008-2012 (Michael Caldeira)
 € 47.040 (PhD grant): SFRH/BD/48148/2008. 2009-2013 (Tatiana Sousa)
 €47.040 (PhD grant): SFRH/BD/84672/2012. 2013-2016 (Vítor Spínola)
 € 53.820 (Post-Doc grant): SFRH/BPD/66177/2009. 2010-2015 (Jorge Pereira)
Projects and grants to be started in 2013:
 €600.000 (€150.000 for CQM): New-INDIGO/0003/2012. 2013-2016; PI: José
Câmara (An attractive and promising strategy for early cancer diagnosis through
the assembly of the Human Cancer Volatome)
33
OBJECTIVES AND ACHIEVEMENTS
Objectives
The goal of the natural products research line is the establishment of capabilities in the
aspects of analysis, characterization and evaluation of core components of foodstuffs, and on
the evaluation and identification of bioactive components of aromatic/medicinal plants, some
of them also used as food constituents, on the search for new therapeutic molecules. The
research is focused not only on the application but also on the development of techniques and
methodologies of chemical analysis of volatile and non-volatile compounds in foodstuffs in
order to characterize them and/or their processes of production and evolution. The same
methods and techniques are being developed to establish chemotypes of botanical subspecies
of Macaronesian biodiversity and to identify and quantify the essential oil and extract
components with the aim of developing selected species into renewable sources of marketable
products such as pharmaceuticals, biocides, fine chemicals, fuels, foods, and supplements. The
same matrixes are characterized and evaluated for bioactive components, with relevance in
food science and pharmacology. New matrixes, such as marine bacteria, are currently under
study for the discovery and the isolation of new compounds with relevant
biological/pharmaceutical properties.
Furthermore, the group aims at building and
maintaining a strong connection with the local institutions, by developing activity in the
research and improvement of Madeira wine, a product of high economic importance, thus
contributing to the development of the insular region where we live. The intertwining of
expertise of the various members of the research group is actively procured in order to
perform applied and fundamental research to achieve our objectives.
At the same time, the group is also developing new analytical methodologies that will
allow an early diagnostic of several types of cancer through the analysis of the volatile
compounds released from biological samples obtained using a non-invading process (like
urine, breath, etc.).
Main Achievements
Through a reasonable number and size of projects that the members were able to
secure during these years, the facilities and analytical park were much improved, leading to
the attraction of national and international researchers and the training of existing
collaborators.
At the end of 2012 the group consisted of 6 PhDs (2 members from the host
institution, 1 from a State Laboratory and 3 Post-Doc researchers), 5 PhD students (FCT
funded) and 4 Master Students, 3 researchers holding a Master’s degree and 1 researcher with
a “licenciatura”. The activity of the research group is demonstrated by the number of projects
and the amount of funding obtained.
In 2012, the group published 16 papers in peer-reviewed journals with an average
impact factor of 3.717 (IF 2011). Seven more papers were accepted for publication in
international journals with impact factor and 5 others have been submitted), 1 book chapter,
and 1 Master thesis. Additionally, 4 oral and 30 poster communications in scientific meetings
were presented.
34
DISTINCTIONS, AWARDS AND MERITS



J.S. Câmara received an award from Sociedade Portuguesa de Senologia as a recognition of
the work done in the field of cancer.
Award for the best poster at the 36th International Symposium on Capillary
Chromatography 2012 (Riva del Garda, Italy): Silva P., Nunes A., Aveiro F., Silva C.L.,
Câmara J.S.; Comparison on volatile urinary metabolomic profile of lung cancer patients
and normal individuals as a powerful tool to finding potential biomarkers.
Paula Castilho is, since November 2009, the representative member of the Area of
Chemistry at the Scientific Board of the Centre of Competence in Exact Sciences and
Engineering.
GROUP PRODUCTIVITY
Published Articles in Peer-Reviewed Journals (IF of 2011)
12.1. Caldeira M.; Perestrelo R.; Barros A.S.; Bilelo M.J.; Parada A.; Morête A.; Câmara J.S.;
Rocha S.M.; Allergic asthma exhaled breath metabolome: a challenge for comprehensive
two-dimensional gas chromatography; J. Chromatogr. A, 2012, 1254, 87-97.(I.F. 4.531)
http://cqm.uma.pt/CQM12/12-3_J Chromatogr_A_.pdf
12.2. Castilho P. C.; Savluchinske-Feio S.; Weinhold T. S.; Gouveia S.C.; Evaluation of the
antimicrobial and antioxidant activities of essential oils, extracts and their main
components from oregano from Madeira Island, Portugal; Food Control, 2012, 23, 552558.(IF: 2.656) http://cqm.uma.pt/CQM12/12-5_Food_Control_.pdf
12.3. Gonçalves J.; Figueira J.; Rodrigues F.; Câmara J.S.; Headspace solid-phase
microextraction combined with mass spectrometry as a powerful analytical tool for
profiling the terpenoid metabolomic pattern of hop-essential oil derived from Saaz variety.
J. Sep. Sci. 2012, 35, 2282-2296. DOI: 10.1002/jssc.201200244.(I.F. 2.733)
http://cqm.uma.pt/CQM12/12-8_J Sep_Sci_.pdf
12.4. Gonçalves J.; Mendes B.; Silva C.L.; Câmara J.S.; Development of a novel
microextraction by packed sorbent-based approach followed by ultrahigh pressure liquid
chromatography as a powerful technique for quantification phenolic constituents of
biological interest in wines; J. Chromatogr. A, 2012, 1229, 13-23. DOI:
10.1016/j.chroma.2012.01.023. (IF: 4.531) http://cqm.uma.pt/CQM12/12-9_J_Chromatogr
A_.pdf
12.5. Gouveia S. C.; Castilho P. C.; Validation of a HPLC-DAD-ESI/MSn method for
caffeoylquinic acids separation, quantification and identification in medicinal Helichrysum
species from Macaronesia; Food Res. Int., 2012, 45, 362-368.(IF: 3.150)
http://cqm.uma.pt/CQM12/12-11_Food Res_Int_.pdf
12.6. Gouveia, S.C.; Castilho, P.C.; Helichrysum monizii Lowe: Phenolic Composition and
Antioxidant Potential; Phytochem. Anal. 2012, 23, 72-83. (IF: 2.633)
http://cqm.uma.pt/CQM12/12-12_Phytochem_Anal_.pdf
35
12.7. Gouveia, S.C.; Castilho, P.C.; Phenolic compounds and antioxidant capacity cultivated
artichoke, wild cardoon from Madeira Island and artichoke - based food supplements;
Food Res. Int., 2012, 48, 712-724. (IF: 3.150) http://cqm.uma.pt/CQM12/12-13_Food
Research International_.pdf
12.8. Mendes B.; Gonçalves J.; Câmara J.S.; Effectiveness of high-throughput miniaturised
sorbent- and solid phase microextraction techniques combined with gas chromatographymass spectrometry analysis for a rapid screening of volatile and semi-volatile composition
of wines - a comparative study; Talanta, 2012, 88, 79-94. DOI:
10.1016/j.talanta.2011.10.010. (IF: 3.794) http://cqm.uma.pt/CQM12/12-20_Talanta_.pdf
12.9. Perestrelo R.; Lu Y.; Santos S.A.; Silvestre A.J.D.; Neto C.P.; Câmara J.S.; Rocha S.M.;
Phenolic profile of Sercial and Tinta Negra Vitis vinifera L. grape skins by HPLC-DAD-ESIMSn. Identification of novel phenolic compounds in Vitis vinifera L. grape; Food Chem.,
2012,
135,
94-104.
doi.org/10.1016/j.foodchem.2012.04.102.
(IF:
3.655)
http://cqm.uma.pt/CQM12/12-28_Food_Chemistry_.pdf
12.10. Perestrelo R.; Rocha S.M.; Câmara J.S.; Solid phase microextraction as a reliable
alternative to conventional extraction techniques to evaluate the pattern of glycosidicallylinked components in Vitis vinifera L. grape varieties; Talanta, 2012, 95, 1-11. DOI:
10.1016/j.talanta.2012.03.005. (I.F. 3.794) http://cqm.uma.pt/CQM12/12-29_Talanta_.pdf
12.11. Pontes M., Pereira J.; Câmara J.S.; Dynamic headspace solid-phase microextraction
combined with one-dimensional gas chromatography-mass spectrometry as a powerful
tool to differentiate banana cultivars based on their volatile metabolite profile; Food
Chem., 2012, 134, 2509-2520. DOI: 10.1016/j.foodchem.2012.04.087. (I.F. 3.655)
http://cqm.uma.pt/CQM12/12-30_Food_Chemistry_.pdf
12.12. Silva C.L.; Haesen, N.; Câmara J.S.; A new and improved strategy combining a
dispersive-solid phase extraction-based multiclass method with ultra-high pressure liquid
chromatography for analysis of low molecular weight polyphenols in vegetables; J.
Chromatogr A., 2012, 1260, 154-163. DOI: 10.1016/j.chroma.2012.08.082. (I.F. 4.531)
http://cqm.uma.pt/CQM12/12-34_J Chromatogr_A_.pdf
12.13. Silva C.L.; Gonçalves J.L.; Câmara J.S.; A sensitive microextraction by packed sorbentbased methodology combined with ultra-high pressure liquid chromatography as a
powerful technique for analysis of biologically active flavonols in wines; Analytica Chimica
Acta
2012,
739,
89-98;
DOI:
10.1016/j.aca.2012.06.020.(IF:
4.555)
http://cqm.uma.pt/CQM12/12-35_Analytica Chimica_Acta_.pdf
12.14. Silva C.L.; Passos, M; Câmara J.S; Solid phase microextraction, mass spectrometry and
metabolomic approaches for detection of potential urinary cancer biomarkers—A
powerful strategy for breast cancer diagnosis; Talanta, 2012, 89, 360-368. DOI:
http://dx.doi.org/10.1016/j.talanta.2011.12.041.(IF:
3.794)
http://cqm.uma.pt/CQM12/12-36_Talanta_.pdf
12.15. Spinola V.; Mendes B.; Câmara J.S.; Castilho P.C.; An improved and fast UHPLC-PDA
methodology for determination of l-ascorbic and dehydroascorbic acids in fruits and
vegetables. Evaluation of degradation rate during storage; Anal. Bioanal. Chem., 2012,
36
403,
1049-1058.
DOI:
10.1007/s00216-011-5668-x.
http://cqm.uma.pt/CQM12/12-37_Anal Bioanal Chem_.pdf
(I.F.
3.778)
12.16. Rocha S. M.; Caldeira M.; Carrola J.; Santos M.; Cruz N.; Duarte I.F.; Exploring the
human urine metabolomic potentialities by comprehensive two-dimensional gas
chromatography coupled to time of flight mass spectrometry; J. Chromatogr A., 2012,
1260,
154-163;
DOI:
10.1016/j.chroma.2012.06.067
(IF:
4.531)
http://cqm.uma.pt/CQM12/12-42_J Chromatogr _A_.pdf
Book Chapters
BC12.1. Gonçalves J.; Câmara J.S.; A Fast and High-throughput MEPS/UHPLC-PDA-based
Methodology for Separation and Identification of Resveratrol in Wine; in Resveratrol:
Sources, Production and Health Benefits; Delmas D. (Editor), Nova Science Publishers,
2012, ISBN: 978-1-62081-997-5
Proceedings With Peer Review
-
Published Papers in International Journals With Peer Review But Without Impact
Factor
WF12.1.
Viciolle E.; Castilho P.C.; Rosado C.; In vitro and in vivo assessment of the effect
of Laurus novocanariensis oil and essential oil in human skin Int. J. Cosmet. Sci. 2012 34,
546-50. DOI: 10.1111/j.1468-2494.2012.00745.x. (it will receive its first Impact Factor in
2013). http://cqm.uma.pt/CQM12/12-Int J of Cosmetic Science 34 546-550.pdf
Accepted Papers in International Journals
AP12.1. Gonçalves J.; Silva C.L.; Castilho P.C.; Câmara J.S.; An attractive, sensitive and highthroughput strategy based on microextraction by packed sorbent followed by UHPLC-PDA
analysis for quantification of hydroxybenzoic and hydroxycinnamic acids in wines;
Microchemical Journal 2013, 106, 129-138; DOI: 10.1016/j.microc.2012.05.037 (IF: 3.048).
AP12.2. Gouveia S.; Gonçalves J.; Castilho P.C.; Characterization of phenolic compounds and
antioxidant activity of ethanolic extracts from flowers of Andryala glandulosa ssp. varia
(Lowe ex DC.) R.Fern., an endemic species of Macaronesia region; Industrial Crops and
Products 2013, 42, 573-582; DOI: 10.1016/j.indcrop.2012.06.040 (IF: 2.469).
AP12.3. Gouveia S.C., Castilho P.C.; Artemisia annua L.: Essential oil and acetone extract
composition and antioxidant capacity Ind. Crops Prod 2013, 45, 170-181 DOI:
10.1016/j.indcrop.2012.12.022 (IF: 2.469).
AP12.4. Haesen, N., Silva C.L., Câmara J.S. New strategy to enhance the extraction efficiency
of polyphenols in food commodities using a modified QuEChERS multi-residue method
37
combined with UHPLC-PDA system; J. Chromatogr A., 2012 (revision Submitted) (I.F.
4.531).
AP12.5. Mendes B., Silva P., Pereira J., Câmara J.S.; A Powerful Micro-Extraction Technique
Using a New Digitally Controlled eVol® Syringe, Combined with Ultrahigh Pressure Liquid
Chromatography for Assessment of Urinary Biomarkers of Oxidative DNA Damage”; Plos
One - PONE-D-12-25716.
AP12.6. Silva C.L.; Câmara J.S.; Profiling of volatiles in the leaves of Lamiaciae species based
on headspace solid phase microextraction and mass spectrometry; Food Research
International DOI: 10.1016/j.foodres.2012.12.040; (IF: 3.150).
AP12.7. Spínola, V., Mendes, B., Câmara, J., Castilho, P.; Effect of time and temperature on
vitamin C stability in horticultural extracts. UHPLC-PDA vs iodometric titration as analytical
methods. LWT - Food Science and Technology, 2013, 50, 2, 489-495; DOI:
10.1016/j.lwt.2012.08.020; (IF: 2.545).
Submitted Papers
SP12.1. Figueira J., Hugo Câmara, Jorge Pereira, José S. Câmara. A powerful strategy coupling
headspace solid phase microextraction and mass spectrometry to profile the volatile
metabolome pattern of different Lycopersicon esculentum L. cultivars (submitted to Food
Chemistry em 20 of November 2012).
SP12.2. Gonçalves J., Rodrigues F.P.; Alves V.; Figueira J.A.; Câmara J.S; An ultra-fast and
sensitive approach based on microextraction using a new digitally controlled syringe
combined with ultra-high performance liquid chromatography to determine
prenylflavonoids in beer; J. Chromatogr A., (IF: 4.531).
SP12.3. Gonçalves J.; Figueira J.; Rodrigues F.P.; Ornelas L.P.; Branco R.N.; Silva C.L.; Câmara
J.S.; A powerful methodological approach combining headspace solid phase
microextraction, mass spectrometry and multivariate analysis for profiling the volatile
metabolomic pattern of beer starting raw-materials; Food Chemistry (IF: 3.655).
SP12.4. Mendes B., Silva P., Pereira J., Mendonça I., Câmara J.S., A new and fast
methodology to assess oxidative damage in cardiovascular diseases risk development
through eVol-MEPS-UHPLC analysis of four urinary biomarkers; Submitted to International
Journal of Cardiology.
Thesis
TH12.1.Mendes, B. R.; Avaliação do Perfil Urinário de Biomarcadores do Stress Oxidativo e a
sua Correlação com as Doenças Cardiovasculares, thesis presented to obtain the MSc
degree in Applied Biochemistry, Universidade da Madeira, 2012.
Abstracts in International Scientific Meetings
38
OCI12.1.
Branco PC, Duarte LC, Torrado I, Roseiro L, Pereira C, Klydjeneiro Z, Castilho
PC, Annona cherimola mill. Seeds as a potential feedstock for the production of biofuels
and bioproducts. IAMAW 1st International Workshop Valorization of Mediterranean
Biowastes and Effluents. 5 - 8 June, 2012, Santarém, Portugal.
PCI12.1. Viciolle E., Castilho P., Rosado C; In vitro and in vivo assessment of the effect of
Laurus novocanariensis oil and essential oil in human skin; Perspectives in Percutaneous
Penetration, 13th International Conference, 11-14 April, 2012, La Grande Motte, France.
PCI12.2. Haesen N., Silva C.L., Pereira J., Câmara J.S., A modified QuEChERS-based strategy
combined with UHPLC-PDA system to improve the extraction efficiency of polyphenols
from dietary vegetables. 38th International Symposium on High Performance Liquid Phase
Separations and Related Techniques, HPLC2012; June 16-21, 2012; California, USA.
PCI12.3. Sousa J.F., Barros J.N., Fernandes P.J., Pereira J., Azenha E., Câmara J.S.; Validation
of a Simple and Sensitive HPLC/FLD method for determination of N-methyl carbamates in
animal tissues based on dispersive QuEChERS. 38th International Symposium on High
Performance Liquid Phase Separations and Related Techniques, HPLC2012; June 16-21,
2012; California, USA.
PCI12.4. Pereira J., Câmara J.S.; Quantification of the biomarker 8-iso-prostaglandin F2α and
its urinary metabolite 2,3-dinor-8-iso-prostaglandin F2α using semi-automatic microextraction in packed syringe combined with ultra-fast liquid chromatography as a new
simplified approach to access oxidative damage. 38th International Symposium on High
PCI12.5. Mendes B., Silva P., Pereira J., Câmara J.S.; Ultrafast and powerful strategy based
on microextraction by packed sorbent and UHPLC-PDA determination for simultaneous
determination of oxidative stress biomarkers. 38th International Symposium on High
PCI12.6. Silva C.L., Gonçalves J., Pereira J., Câmara J.S.; Coupling Microextraction Packed
Sorbent with UHPLC-PDA system as a Powerful approach for myricetin, quercetin, and
kaempferol quantification in wine extracts. 38th International Symposium on High
PCI12.7. Spínola V., Mendes B., Câmara J.S., Castilho P.C.; A powerful UHPLC-PDA
methodology for determination of l-ascorbic acid content in fruits and vegetables - a
comparative evaluation with iodometric titration. 38th International Symposium on High
39
PCI12.8. Gonçalves J., Rodrigues F., Figueira J.A., Laura Ornelas, Bruno Branco, Silva C.L.,
Câmara J.S.; Profiling the volatile metabolomics pattern of beer starting raw-materials
based on headspace solid phase microextraction, mass spectrometry and multivariate
analysis. 36th International Symposium on Capillary Chromatography (ISCC) 2012. Riva del
Garda. Italy
PCI12.9. Gonçalves J., Rodrigues F., Figueira J.A., Câmara H., Figueira P., Ornelas L., Branco
N., Silva C.L., Câmara J.S.; Optimization and validation of a new strategy coupling a semiautomatic micro-extraction by packed syringe and ultrahigh pressure liquid
chromatography for determination of Xanthohumol and Isoxanthohumol in beer. 36th
International Symposium on Capillary Chromatography (ISCC) 2012. Riva del Garda. Italy
PCI12.10. Pereira J., Mendes B., Silva P., Silva C.L., Câmara J.S.; Semi-automatic microextraction in packed syringe combined with ultrahigh pressure liquid chromatography as a
fast and simplified methodology to assess oxidative damage through quantification of 8iso-prostaglandin F2α biomarker in urine. 36th International Symposium on Capillary
Chromatography (ISCC) 2012. Riva del Garda. Italy
PCI12.11. Silva C.L., Haesen N., Câmara J.S.; A new and improved strategy combining a
modified QuEChERS-based multi-residue method with dispersive-solid phase extraction
followed by ultrahigh pressure liquid chromatography for analysis of polyphenols in
vegetables. 36th International Symposium on Capillary Chromatography (ISCC) 2012. Riva
del Garda. Italy
PCI12.12. Silva P., Nunes A., Aveiro F., Silva C.L., Câmara J.S.; Comparison on volatile urinary
metabolomic profile of lung cancer patients and normal individuals as a powerful tool to
finding potential biomarkers. 36th International Symposium on Capillary Chromatography
(ISCC) 2012. Riva del Garda. Italy
PCI12.13. Silva P., Mendes B., Silva C.L., Pereira J., Aveiro F., Câmara J.S.; A reliable and
ultrafast MEPS/UHPLC-PDA-based methodology for assessment of urinary biomarkers of
oxidative stress in oncologic pathologies. 36th International Symposium on Capillary
Chromatography (ISCC) 2012. Riva del Garda. Italy
PCI12.14. Mendes B., Silva P., Pereira J., Silva C.L., Câmara J.S.; Quantification of urinary
biomarkers of oxidative DNA damage by MEPS/UHPLC-PDA-based methodology. 36th
International Symposium on Capillary Chromatography (ISCC) 2012. Riva del Garda. Italy
PCI12.15. Figueira J.A., Câmara H., Silva C.L., Câmara J.S.; A powerful strategy coupling
headspace solid phase microextraction and mass spectrometry to profile the volatile
metabolome pattern of different Lycopersicon esculentum L. Cultivars. 36th International
Symposium on Capillary Chromatography (ISCC) 2012. Riva del Garda. Italy
PCI12.16. Silva P., Nunes A., Aveiro F., Silva C.L., Câmara J.S.; An exploratory study based on
mass spectrometry metabolomics to establish the urine molecular pattern in lung cancer
patients. 36th International Symposium on Capillary Chromatography (ISCC) 2012. Riva del
Garda. Italy.
PCI12.17. Perestrelo, R.; Lu, Y.; Santos, S. A. O.; Silvestre, A. J. D.; Neto, C. P.; Câmara, J. S.;
Rocha, S. M.; Phenolic profile of Sercial and Tinta Negra Portuguese varieties: Novel
40
phenolic compounds in Vitis vinifera L. grape, International Congress on Natural Products
Research, New York, USA, 28 July – 1 August, 2012.
Abstracts in National Scientific Meetings
OCN12.1. Perestrelo R, Câmara J.S., Rocha S.M.; GC x GC-ToFMS data processing strategies to
search varietal, ageing markers, and contaminants in Madeira wine. 7º Encontro Nacional
de Cromatografia, January 2012, Porto, Portugal.
OCN12.2. Ribeiro Carrott M, Cansado I, Russo P, Carrott P, Catrinescu C, Castilho PC,
Fernandes C, Breen C. Porosity of acid activated Porto Santo bentonites assessed by nnonane pre-adsorption and nitrogen adsorption, Symposium in Honour of Ramôa Ribeiro:
Catalysis: From the Active Site to the Process, October 9th 2012, IST, Lisboa, Portugal.
OCN12.3. Spínola V, Mendes B, Câmara JS, Castilho PC, UHPLC-PDA as An Improved and
Ultrafast Methodology for Determination of L-Ascorbic and Dehydroascorbic acids in fruits
and vegetables. 7º Encontro Nacional de Cromatografia ENC2012 - SPQ 9-11 Janeiro 2012,
Porto, Portugal.
PCN12.1. Silva C.L., Gonçalves J., Câmara J.S.; Efficient and high throughput
microextraction packed sorbent-based methodology combined with Ultrahigh
Performance Liquid Chromatography as a powerful technique for analysis of
biologically active flavonols in wines. 7º Encontro Nacional de Cromatografia, January
2012, Porto, Portugal.
PCN12.2. Gonçalves J., Mendes B., Silva C.L., Câmara J.S.; Determination of wine
secondary bioactive metabolites through a novel microextraction by packed sorbentbased analytical approach and Ultrahigh Performance Liquid Chromatography. 7º
Encontro Nacional de Cromatografia, January 2012, Porto, Portugal.
PCN12.3. Haesen N., Silva C.L., Câmara J.S.; Implementation of a Simple and rapid
QuEChERS/UHPLC-PDA multi-residue method for quantification of polyphenols in food
commodities. 7º Encontro Nacional de Cromatografia, January 2012, Porto, Portugal.
PCN12.4. Silva P., Silva C.L., Aveiro F., Câmara J.S.; Solid-phase microextraction-based
methodology in order to assess potential breast cancer biomarkers through volatile
urinary metabolomic pattern. 7º Encontro Nacional de Cromatografia, January 2012,
Porto, Portugal.
PCN12.5. Pereira J., Câmara J.S.; Fast quantification of the oxidative damage biomarker
8-iso-prostaglandin F2alpha in urine using micro-extraction in packed syringe
41
combined with ultra-fast liquid chromatography. 7º Encontro Nacional de
Cromatografia, January 2012, Porto, Portugal.
PCN12.6. Nunes A., Silva P., Aveiro F., Câmara J.S.; Non-invasive sampling process
combined with HS-SPME/GC-qMS for Detection Lung Cancer markers based on
Chromatographic profile of urinary endogenous metabolites. 7º Encontro Nacional de
PCN12.7. Mendes B., Câmara J.S.; A sensitive method coupling ultra-high performance
liquid chromatography with photodiode array detection as useful tool for
quantification stress oxidative biomarkers in biological fluids. 7º Encontro Nacional de
PCN12.8. Sousa J.F., Barros J.N., Santos L., Oliveira A.L., Gonçalves M.J., Fernandes P.J.,
Azenha E., Câmara J.S.; Development and validation of a Simple and Sensitive HPLCFLD method for N-methyl carbamates pesticides determination in animal tissues based
on dispersive extraction by QuEChERS. 7º Encontro Nacional de Cromatografia,
January 2012, Porto, Portugal.
PCN12.9. Reis P., Vieira R., Câmara J.S.; A selective and fast method for the quantitative
determination of chloroanisoles in wines Using Solid Phase Microextraction and Gas
Chromatography-Quadrupole Mass Spectrometry 7º Encontro Nacional de
PCN12.10. Gonçalves J., Figueira J.A., Rodrigues F., Ornelas L., Branco N., Câmara J.S.;
Headspace solid phase microextraction as a powerful tool to obtain a rapid fingerprint
of the volatile metabolomic profile of the hop-oil-derived compounds. 7º Encontro
Nacional de Cromatografia, January 2012, Porto, Portugal.
PCN12.11. Silva C.L., Aveiro F., Câmara J.S.; Solid phase microextraction, mass
spectrometry and metabolomic approaches as powerful strategies for detection of
urinary volatile metabolites as potential cancer biomarkers. 7º Encontro Nacional de
PCN12.12. Mendes B., Gonçalves J., Câmara J.S.; Effectiveness of high-throughput
miniaturized sorbent- and solid phase microextraction techniques for a rapid screening
of volatile composition of wines – a comparative study. 7º Encontro Nacional de
PCN12.13. Martins, C., Perestrelo, R., Câmara, J.S., Rocha, S., Profiling the Madeira wine
volatile fatty acids: evaluation of aging effect. 11º Encontro de Química dos Alimentos.
16-19 Setembro, 2012. Bragança.
ORGANIZATION OF CONFERENCES
42
INTERNATIONALIZATION
Although the 2012 publications showed predominantly results of national
collaborations, international cooperation was actively pursued. Some previously established
collaborations with the Instituto Canario de Investigacion en Cancer, the Institute of
Tuberculosis Research, University of Chicago Illinois and the Instituto Politecnico Nacional of
Mexico, were of key importance for the ongoing research programs on the isolation,
characterization and evaluation of metabolites of plant origin, with special incidence on those
with antitumor and antituberculosis activity. New projects will bring new partnerships with
international institutions such as the prestigious Scripps Institution of Oceanography University of California San Diego (SIO-UCSD). This institute is a partner in the project “Ocean
Treasures” which aims to explore the active metabolites produced by deep sea bacteria from
Madeira Island. Old partnerships are being revived. Back in 2000, collaboration with the
Materials and Engineering Research Institute (MERI) from Sheffield Hallam University, UK, was
established in the form of the CLAYCATS project for the production and characterization of
clay-based catalysts. This collaboration is now re-opened in the form of the CLAYCATS4
project, a more focused project on the application of catalysts on biomass conversion and
bioactive molecules hemisynthesis.
In addition, a large Indo-European consortium will be involved in the recent approved
project (Indigo Project) headed by J.S. Câmara (An attractive and promising strategy for early
cancer diagnosis through the assembly of the Human Cancer Volatomics). The partners
involved are: INDIA: National Center for Cell Science (NCCS), Ganeshkhind, Pune (Indian
Coordinator, Prof. Rapole Shrikanth) and Centre for DNA Fingerprinting & Diagnostics (CDFD)
Bldg7, Gruhakalpa, Nampally (Prof. Hampapathalu Nagarajaram); GERMANY: University of
Rostock, Faculty of Medicine (Prof Jochen Klaus Schubert).
PROGRAMMED ACTIVITIES FOR 2013
 Organization of the 2nd Edition of the annual Natural Products Meeting/CQM, 2013.
43
CQM F ACTS AND FIGURES
HUMAN RESOURCES
The research team of CQM (M-male, F-female) is composed of the following
categories:
CQM research staff (end-of-year situation) 2012
Ph Ds
Ph D Students
Co-workers
Master Students
Researchers with a Master degree
Other co-workers
TOTAL
M
11
5
F
6
4
Total
17
9
2
4
1
23
5
7
4
26
7
11
5
49
Research Team
24
25
20
17
16
15
15
13
11
10
9
11
10
5
8
4
2
7
3
17
20
19
18
23
17
15
12
9
Ph Ds
10
8
9
5
Ph D Students
Co-workers
0
2004 2005 2006 2007 2008 2009 2010 2011 2012
Only about 82% of CQM researchers are working on full time in research. The
remaining 18% have to do research, administrative and teaching activities. The research team
average age is 34 years.
44
BUDGET 2004-2016
The 2012 budget of CQM for 2012 was around €462.174. This amount, together with
previously funded projects supported by different entities (e.g. FCT, INTERREG IIIB), sum-up to
more than €5 million (until 2016).
€ 232.641; 4.6%
RE-EQUIPMENT PROJECTS
FCT PLURI-ANNUAL (2004-2012)
€ 721.702; 14.3%
€1 498 810; 29.8%
€ 1 571 55 5;
31.2%
€ 963.406; 19.1%
€ 48.218; 1%
NATIONAL PROJECTS (FCT, AdI)
EUROPEAN PROJECTS (INTERREG
IIIB)
OTHER PROJECTS
HUMAN RESOURCES (FCT GRANTS)
In the 2004-2016 period the direct and indirect FCT support reaches the total amount
of €4 million (ca. 80% of the total available budget).
45
PUBLICATIONS 2004-2012
At the end of 2012, the CQM had 250 publications, including 162 with impact factor
(43 published in 2012).
Publications
250
Technical Rep
200
Spreading Science
150
National Journals
100
Thesis
Proceedings
50
Books
0
Without Impact Factor
With Impac Factor
Impact Factor
4,600
5,00
3,868
Impact Factor
4,00
3,00
4,183
2,775 2,980 2,952
2,124 2,077 2,177
2,00
1,00
,00
2004 2005 2006 2007 2008 2009 2010 2011 2012
Year
46
The distribution of the number of CQM publications versus the impact factor, in the
period 2004-2012, shows that 78% have an impact factor greater than 2.6 and 43% greater
than 3.5.
Number of Papers vs Impact Factor
2004-2012
70
70
57
60
50
40
25
30
20
10
10
0
0-1.5
1.6-2.5
2.6-3.5
> 3.5
47
CQM BIBLIOMETRIC RESULTS 2007- 2010
The Foundation for Science and Technology ( FCT-IP) recently published the results of a
commissioned bibliometric study from the Center for Science and Technology Studies (CWTS)
of the University of Leiden (http://bit.ly/1c7cf6L ). The principal aim of this study was to map
the scientific contributions of the Research Units and Associated Laboratories supported by
the pluriannual funding program of FCT-IP. The study examined all publications of each of the
funded institutions that are registered on the WoS – Web of Science between the years 2007
and 2010, and produced a set of indicators to compare and assess the quality of scientific
output.
The statistical analysis of bibliometric indicators shows that, in the considered period,
the Centro de Química da Madeira (CQM) reached an excellent standard of quality, achieving
the highest score in two (MNCS & PP(top 10%)) of the eight indicators (see next graph).
Instituto De Tecnologia
Química E Biológica (ITQB) (Ass.
Lab.)
MCS
Centro De Química Da Madeira
PP(int collab)
1/PP(uncited)
Centro De Química Estrutural
PP(collab)
MNCS
Coverage
MNJS
REQUIMTE - Laboratório
Associado Para A Química
Verde (Ass. Lab.)
Centro De Química - Vila Real
PP(top10%)
Centro De Química De Évora
Graph: Statistical analysis of bibliometric indicators for the chemistry area: PP (top10%) –
Percentage of highly cited publications; MNCS – Mean field normalized citation score (The full
list of abbreviations and related details is available in page 50 of this report).
Considering all indicators, and comparing with all portuguese institutions that
conducted research in the field of Chemistry (15), the CQM lies the in the second place (see
next graph). This result is especially important given that from the first four institutions, the
CQM is the only one with less than a hundred researchers.
48
Graph: Score of the first eight portuguese institutions that conduct research in the field of
Chemistry in Portugal (Data based in publications from 2007-2010; WoS – Web of Science).
49
Abbreviations list used in the study (From FCT-IP web site):
•
P – Number of publications in international journals of the unit of analysis in the entire
•
MCS – Average number of citations without self citations per paper;
•
PP (uncited) – Percentage of publications not cited by others (in the given time period);
period;
•
MNCS – Mean field normalized citation score. This is the actual number of citations
(without self citations) divided by the expected number of citations on a paper basis. The expected
number of citations is based on the world-wide average citation score without self-citations of all similar
papers belonging to the same field (journal subject category). In this way, a field normalized score is
calculated for each paper. Next, the MNCS indicator is computed for the unit of analysis by taking the
average of these field-normalized citation scores for individual papers. A value above 1 indicates that
the mean impact for the unit is above world average whereas a value below 1 indicates the opposite.
•
MNJS – Mean normalized journal score. Indicates the average citation impact of the
journals that are used by the unit and is calculated based on the same principles as the MNCS. The
indicator shows whether the unit publishes in top or in sub-top journals.
•
PP (top10%) – Percentage of highly cited publications. Indicates the average citation
impact of the journals that are used by the unit and is calculated based on the same principles as the
MNCS. The indicator shows whether the unit publishes in top or in sub-top journals.
•
Coverage – Internal coverage. Measured by the proportion of cited references in the
oeuvre linking to other WoS publications;
•
PP (collab) – Publications that are done in institutional collaboration (the shares are
calculated based on the total number of publications);
•
PP (int collab) – Publications that are perfomed among institutions of more than one
country (the shares are calculated based on the total number of publications);
"no collaboration" - Publications from a single FCT institute;
"national collaboration" - Publications from at least two authors in the same country
(Portugal);
"international collaboration" - Publication from FCT funded institutes with one or more
foreign (non-Portuguese) institutions.
50
H APPENINGS AT CQM IN 2012
January - 7th Materials Group Meeting - 27th of January
April
- XIV Iberic Meeting of Electrochemistry & XVII Meeting of the Portuguese Electrochemical
Society – 11-14 of April (João Rodrigues (CQM) – Chairman);
- Electrochemical Characterization of Biomaterials and Magnesium Alloys Using
Electrochemical Techniques - 20 of April – Lúcia Nascimento – Berlin Institute of Technology.
May
- Novel Biofunctional Materials from Dendron Building Blocks - 22 of May - Amitav Sanyal University Istanbul, Turkey;
- Dendron-Linear Polymer Constructs for Drug Delivery Applications - 25 of May - Rana Sanyal –
University Istanbul, Turkey.
June
- 1st Course on Fundamentals and Applications of Electrospinning Technology – 15 of June –
Shili Xiao (CQM);
- Tesouros Oceanicos - dos sedimentos aos compostos bioactivos – 15 of June – Susana
Gaudêncio – REQUIMTE – Portugal;
-Ocean Treasures - Marine microbes, source of pharmaceuticals – 15 of June – Paul Jensen –
SIO Univ. of California at San Diego - USA.
July
- Estágios de Verão no CQM/Training at CQM during holidays;
- Ciência Viva no Laboratório – OCJF/Scientific occupation of young students during holiday
time
September – 1st Edition of the Master Course in Nanochemistry and Nanomaterials started.
October – Nanoschool -15-19 of October – Invited guest Etienne Duguet - Univ. of Bordeaux France.
November – “A Química é Divertida/Chemistry is Fun” – SEMANA C&T 2012 Science and
Technology Week – 22, 23, 24 and 28 of November.
December – PTNMR - 2nd NMR Course – Short Theoretical and Practical Introduction in the
NMR Techinique – 13-14 of December – João Figueira (CQM).
51
A CKNOWLEDGMENTS
REDE/1517/RMN/2005
52
REDE/1508/RE
M/2005
A PPENDIX
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
PART OF OUR TEAM IN 2012
69

Annual Scientific Report 2012 - Centro de Química da Madeira

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