Georgian Abstracts

32
klinikuri da eqsperimentuli endokrinologiis moambe
PP-05
diabeturi neiropaTiis mkurnaloba Saqriani diabeti
tipi 22-iT daavadebul pirebSi
l. nikoleiSvili, r. yuraSvili
saqarTvelos diabetis centri, Tbilisi, saqarTvelo;
problemis
problemis aqtualoba da mizani: diabeturi neiropaTia Saqriani diabeti tipi 2-is
yvelaze xSiri garTulebaa. dReisaTvis diabeturi neiropaTiis paTogenezuri
meqanizmis mkurnalobisaTvis gamoiyeneba α-lipois mJava, romelic amcirebs
qsovilebsa da plazmaSi Warbad dagrovili glikozirebisa da lipoqsidaciis
produqtebs da oqsidaciur stress. Cveni kvlevis mizani iyo Segvefasebina diabeturi
neiropaTiis mkurnalobis Sedegebi mkacri glikemiuri kontroliTa da α-lipois
mJaviT (preparati Tiogama; Worwag pharma); Sefasebis kriteriumebad gamoviyeneT
diabeturi neiropaTiis simptomebisa da niSnebis regresia.
masala da meTodebi: preparat Tiogamas moqmedebis Sedegi diabetur neiropaTiaze
SeviswavleT Saqriani diabeti tipi 2-is mqone 145 pacientSi, romelTac
aReniSnebodaT periferiuli da avtonomiuri neiropaTia: eseni iyvnen 90 mamakaci da
55 qali saSualo asakiT 59.0 ± 13.5 weli da diabetis saSualo xangrZlivobiT 14.5 ±
9.34 weli. glikohemoglobinis saSualo maCvenebeli iyo 8.4 ± 1.9%. pacientebi
mkurnalobdnen sulfonilSardovanas preparatebiT (glimepiridi, gliklazidi),
agreTve metforminiT an insuliniT. periferiuli da avtonomiuri neiropaTiis
niSnebisa da simptomebis pirveladi Sefasebis Semdeg, pacientebs daeniSnaT preparati
Tiogama (20 ml) intravenurad 21 dRis ganmavlobaSi, xolo Semdeg igive preparati
(600 mg abebi) peroralurad 12 kviris ganmavlobaSi mkurnalobamde da mkurnalobis
Semdeg pacientebs CautardaT gamokiTxva diabeturi neiropaTiis niSnebisa da
simptomebis Sefasebis 5-safexuriani kiTxvaris gamoyenebiT, agreTve nevrologiuri
gamokvleva. mkurnalobis Sedegebis mixedviT pacientebi daiyo 2 jgufad. jg.1 –
pacientebi, romelTac HbA1C<7.5% da jg.2 – pacientebi, romelTac HbA1C>7.5%.
Sedegebi: periferiuli neiropaTiis yvelaze xSiri niSnebi da simptomebi iyo dabuJeba
(mkurnalobamde 90%-Si / mkurnalobis Semdeg gaumjobesda an normalizda 83% (jg.1)
/ 43% (jg.2); Ramis tkivili (48%/32%/12%); wvis SegrZneba (78%/48%/34%);
diskomforti kibeebze asvlis dros (65%/34%/25%); daqveiTebuli vibraciuli
mgrZnobeloba (80%/70%/46%). autonomiuri neiropaTiis yvelaze xSiri niSnebi da
simptomebi iyo: ereqciis disfunqcia (75%/25%/13%); Zilianoba (77%/59%/30%);
terfis kanis simSrale (98%/75%/40%); posturaluri hipotenzia (65%/47%/35%).
diabeturi neiropaTiis simptomebisa da niSnebis saSualo procentuli maCvenebeli
mkurnalobamde da mkurnalobis Semdeg mniSvnelovnad dabali iyo jg.1 (21.4±13.4)
iseve, rogorc jg.2 (44.2±10.7), vidre mkurnalobamde (75.0±14.7); (p<0.001). igive
parametrebis gaumjobeseba mniSvnelovnad maRali iyo jg.1-Si (52.56%±20.48) jg.2-Tan
(30.89%±16.34) SedarebiT (p=0.009).
daskvna:
daskvna: TiogamiT mkurnaloba mniSvnelovnad amcirebs diabeturi neiropaTiis
simptomebsa da niSnebs da gansakuTrebiT efeqturia, roca glikohemoglobinis
maCvenebeli 7.5%-ze dabalia.
 keem, 2004, 1(1): 32