Georgian Abstracts
Transcrição
Georgian Abstracts
32 klinikuri da eqsperimentuli endokrinologiis moambe PP-05 diabeturi neiropaTiis mkurnaloba Saqriani diabeti tipi 22-iT daavadebul pirebSi l. nikoleiSvili, r. yuraSvili saqarTvelos diabetis centri, Tbilisi, saqarTvelo; problemis problemis aqtualoba da mizani: diabeturi neiropaTia Saqriani diabeti tipi 2-is yvelaze xSiri garTulebaa. dReisaTvis diabeturi neiropaTiis paTogenezuri meqanizmis mkurnalobisaTvis gamoiyeneba α-lipois mJava, romelic amcirebs qsovilebsa da plazmaSi Warbad dagrovili glikozirebisa da lipoqsidaciis produqtebs da oqsidaciur stress. Cveni kvlevis mizani iyo Segvefasebina diabeturi neiropaTiis mkurnalobis Sedegebi mkacri glikemiuri kontroliTa da α-lipois mJaviT (preparati Tiogama; Worwag pharma); Sefasebis kriteriumebad gamoviyeneT diabeturi neiropaTiis simptomebisa da niSnebis regresia. masala da meTodebi: preparat Tiogamas moqmedebis Sedegi diabetur neiropaTiaze SeviswavleT Saqriani diabeti tipi 2-is mqone 145 pacientSi, romelTac aReniSnebodaT periferiuli da avtonomiuri neiropaTia: eseni iyvnen 90 mamakaci da 55 qali saSualo asakiT 59.0 ± 13.5 weli da diabetis saSualo xangrZlivobiT 14.5 ± 9.34 weli. glikohemoglobinis saSualo maCvenebeli iyo 8.4 ± 1.9%. pacientebi mkurnalobdnen sulfonilSardovanas preparatebiT (glimepiridi, gliklazidi), agreTve metforminiT an insuliniT. periferiuli da avtonomiuri neiropaTiis niSnebisa da simptomebis pirveladi Sefasebis Semdeg, pacientebs daeniSnaT preparati Tiogama (20 ml) intravenurad 21 dRis ganmavlobaSi, xolo Semdeg igive preparati (600 mg abebi) peroralurad 12 kviris ganmavlobaSi mkurnalobamde da mkurnalobis Semdeg pacientebs CautardaT gamokiTxva diabeturi neiropaTiis niSnebisa da simptomebis Sefasebis 5-safexuriani kiTxvaris gamoyenebiT, agreTve nevrologiuri gamokvleva. mkurnalobis Sedegebis mixedviT pacientebi daiyo 2 jgufad. jg.1 – pacientebi, romelTac HbA1C<7.5% da jg.2 – pacientebi, romelTac HbA1C>7.5%. Sedegebi: periferiuli neiropaTiis yvelaze xSiri niSnebi da simptomebi iyo dabuJeba (mkurnalobamde 90%-Si / mkurnalobis Semdeg gaumjobesda an normalizda 83% (jg.1) / 43% (jg.2); Ramis tkivili (48%/32%/12%); wvis SegrZneba (78%/48%/34%); diskomforti kibeebze asvlis dros (65%/34%/25%); daqveiTebuli vibraciuli mgrZnobeloba (80%/70%/46%). autonomiuri neiropaTiis yvelaze xSiri niSnebi da simptomebi iyo: ereqciis disfunqcia (75%/25%/13%); Zilianoba (77%/59%/30%); terfis kanis simSrale (98%/75%/40%); posturaluri hipotenzia (65%/47%/35%). diabeturi neiropaTiis simptomebisa da niSnebis saSualo procentuli maCvenebeli mkurnalobamde da mkurnalobis Semdeg mniSvnelovnad dabali iyo jg.1 (21.4±13.4) iseve, rogorc jg.2 (44.2±10.7), vidre mkurnalobamde (75.0±14.7); (p<0.001). igive parametrebis gaumjobeseba mniSvnelovnad maRali iyo jg.1-Si (52.56%±20.48) jg.2-Tan (30.89%±16.34) SedarebiT (p=0.009). daskvna: daskvna: TiogamiT mkurnaloba mniSvnelovnad amcirebs diabeturi neiropaTiis simptomebsa da niSnebs da gansakuTrebiT efeqturia, roca glikohemoglobinis maCvenebeli 7.5%-ze dabalia. keem, 2004, 1(1): 32
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