1 | Página - BEB - PHD Programme - Center for Neuroscience and

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Index
1.
Introduction 4 2.
Facts and Figures 9 3.
Organization of PDBEB 10 4.
Courses 12 5.
Seminars 22 6.
Teachers 37 7.
Institutional Consortium 47 8.
Other programmes that benefit from PDBEB 48 9.
Students, location, supervision and research focus 49 57 11. Acomplishment and progress of the students 58 12. Funding 67 10. Annual Meeting 3|Página
1. Introduction, comments on the last five years, and some ideas for the future Education at CNC is focused on the domain of molecular life sciences related to disease, namely in the fields of cell and molecular biology, neurosciences and biotechnology. In October 2002 CNC, with the financial support of FCT, launched an International Doctoral Programme in Experimental Biology and Biomedicine to provide advanced, multidisciplinary, research‐oriented training in emerging areas of modern Biology and Biomedicine. Through this graduate studies programme, scientific education and training of PhD and Master students at a National level is provided. An international PhD programme and a Master programme are organized, aiming to prepare talented, motivated students for independent research projects. The programme is organized in short intensive courses and seminars taught by top scientists selected in the areas, favouring the development of research networks at CNC. The coursework also includes lab rotations in CNC labs, during which the students get acquainted with research groups and start contacts towards choosing a project. There are mainly two options for the students: some prefer to chose an already‐defined project advertised by a PI, others identify areas of interest and draft some ideas, and a final project is agreed upon after dialogue with the prospective supervisor. The Programme Committee must approve all projects, but so far the need for a more defined structure has not been felt. The programme provides advanced, research‐oriented training in emerging areas of contemporary Biology and Biomedicine, namely: „
Molecular Cell Biology „
Neuroscience and Disease „
Molecular Biotechnology „
Medical and Environmental Toxicology „
Biophysics and NMR „
Microbiology „
Development and Reproductive Biology „
Visual Sciences 4|Página
The aim of the CNC graduate studies programme is to provide Master and PhD students with a multi‐faced education in those scientific fields, through an international doctoral programme. Besides the twelve scholarships provided, CNC has gone to great efforts to recruit other students (Masters, PhD) to boost course participation without loss of quality, and thus maximize the enormous effort (both financial and logistical) to gather in Coimbra top‐level speakers from different fields. Note that non‐Programme PhD (i.e., students with independent research fellowships) and Masters students are only asked to participate in a few courses/lectures, not the entire Programme. In our opinion the Programme has been very successful in terms of attracting top‐level students (average acceptance rate is around 10%) that carry out the tasks expected of them. We plan to try to increase the pool of applicants by advertising the Programme to other prospective students, outside our normal recruiting pool (e.g. Portuguese students studying abroad). Throughout the years only one student has ever left the Programme, in the first few months and for personal reasons. The publication record on the students in the Programme (see further sections) is also noteworthy, and we therefore believe that they are given the right tools to produce at the highest level. In previous editions the students have been encouraged to embark on projects that involve collaborations between national and foreign laboratories, an approach that has been made mandatory since 2006. The aim was to promote development of high‐level thesis, encourage networking and internationalization of national laboratories, while allowing the students to maintain ties with the national institutions that will permit them to work in our country after finishing their PhDs. Since 2008 a new emphasis has emerged, due to two main changes. On one hand, recent years have brought about a widespread development of novel PhD Programmes in Portugal at several Institutions, which can receive a large number of students, thus increasing the options for those who wish to work in specific laboratories. On the other hand, the CNC has grown in terms of PIs and quality of Science produced, and it seems logical to use these highly trained students to help develop the Center as an Associated Laboratory. Therefore, it has been decided that all projects must now involve concrete collaborations with CNC groups and researchers, as well as international collaborations. Other changes are planned if the Programme is renewed, also in accordance with the External Evaluations that were requested (attached to this report). 5|Página
There are a few main concerns pointed out in the reports. One relates to benchmarks regarding both the students and Programme. Although we have a continuing evaluation of all students, it might be useful to conduct a more formal evaluation of performance close to the end of the coursework, in the event that some students would be better off leaving the Programme. This has not felt to be necessary so far, but might be useful in the future. Of course, a main problem in this case would be what to do with the scholarship awarded to a student that leaves. One hypothesis would be that only the approved students receive the scholarship 6 months into their first year (scholarship would still be for 4 years), but this would have to be negotiated with FCT, if the Programme is renewed. In terms of how the Programme performs in relation to other similar Programmes, or other ways of obtaining the degree (as asked by one evaluator), we have currently no means of assessing this, as we would need the equivalent reports, names of students in other Programmes, etc. Only informal discussions have ever taken place between Programme Committees. One suggestion would be that PhD Programmes funded (directly or indirectly) by FCT might be gathered under a single umbrella (perhaps in an event/Committee sponsored by FCT), and these issues might be discussed more fully, problems identified and benchmarks agreed upon. We are certainly available for this, but believe that the driving force cannot (and should not) be one Programme in particular, but a governing body. Also important to note is that the Course format is extremely interactive and cutting‐edge, more like specialized mini‐conferences discussing recent data (i.e. Gordon Conferences, Keystone Syymposia, etc) than “classical” lectures. Thus we believe that it cannot (and should not) be measured against the background of differently structured (and more common) Ph.D. Programmes. At any rate, it is clear from our point of vue that the Programme at CNC has been invaluable in boosting our publication record, and in developing the Center as an Associated Laboratory. There are 12 BEB students each year at CNC and over three times this number of non‐BEB students that also enroll at CNC as a Research Institute by other means (i.e. direct FCT Ph.D. fellowships). Although it would be fastidious to list all these students and their publications, a cursory examination revealed that, although both types of students publish well, BEB students have (on average) a higher percentage of high‐impact publications, thus stressing the importance and success of the Programme. Another concern is that a high percentage of students have taken more than 4 years to complete their thesis. The funding for the extra years comes usually from the lab the student is working 6|Página
in, not from the Programme. We have tried to challenge the students to complete their work on schedule, but the reason for the delay is almost always that students have chosen high risk‐high reward long‐term PhD projects, and want to obtain the best possible publication record for a succesful postdoctoral career. We will try to work with students and supervisors on this, although we feel that, as long as the student can procure funding for the additional time, this issue is not as crucial as it sounds (i.e. it is actually similar to the USA model). Another crucially important issue to consider is institutional bureaucracy, which can mean an extra 6‐8 months between thesis completion and defence, and thus make the problem seem more serious. CNC is working with the University to try and streamline these procedures. Since 2008/09 we have also tried to concentrate course work and create optional courses, thus allowing the students more time to work on preparing their thesis project, and starting lab work, as soon as possible in the first year. In a related issue, CNC PIs are participating in several events related to student mentoring to provide closer monitoring, especially of students performing work mostly abroad. The Programme Committee will also strive to address any issues that may come up in terms of disagreements between students and supervisors that could require mediation. This has been done informally in the past, as only two students have had problems that warranted a change in lab/project, and both were successfully solved (one thesis completed, one close to completion). Recently BEB students from the first editions have come to lecture in the Programme, providing a great example for the new students. We plan to follow the career of all BEB students, post their current positions and achievements online, and ask them to come back for lectures. These students will always be treated as possible CNC hirees. Courses in other areas will be contemplated in future editions, given not only scientific developments, but also new PI hires at the CNC (e.g. Systems Biology, Immunology, Cell Biology of Infection), and perceived student necessities. For example, teaching on science writing (manuscripts, grants, press releases), ethical aspects and career development is planned for 2009/10, and will be a feature in future editions. The relatioship with Biocant (where graduate Programmes in enterpreneurship are planned) will also be a new feature, as these courses might also be offered to BEB students. However BEB does not offer a specific teaching portfolio during the coursework, because BEB is based at a Research institute and with researchers from several backgrounds and different Faculties, with distinct ways of approaching teaching, and very different needs. Other University of Coimbra students based in groups with responsabilities in teaching at specific Faculties do have that aspect developed, and 7|Página
BEB students will as well, if they do their project in one of those groups. But we do not think it would be useful to include this aspect. In continuing with a recent philosophy, another aspect that will be developed independently of the evaluation issue mentioned above is relationships with other PhD Programs, both nationally (e.g. GABBA, MIT‐Portugal), and internationally (e.g. Kings College, London), so that students from BEB can interact with students from other Programmes. BEB courses will thus be offered as optional for students from other Programmes, and there will be reciprocity in this relationship. Finally, the recent announcement of novel PhD Programmes for practicing MDs (i.e. PhDs in a clinical setting) has not escaped our attention, given that Coimbra has a large Public Hospial, and that a high percentage of CNC research is Medically‐oriented. We already have had some inquiries, and have one MD who has enrolled (as an individual, not yet affiliated with a Programme) in several BEB courses already. We are just waiting for the legal and financial frameworks to be available to offer an appropriate selection of our courses for this purpose, and thus participate in the development of this type of Programme. We are of course available if further infomation is required, Sincerely, João Ramalho‐Santos (current BEB Coordinator) Luís Pereira de Almeida (former BEB Coordinator) 8|Página
2. Facts and Figures The following figures revealed activities of the programme during 2005‐2007: a.
Number of courses i. 4th Edition – 2005/2006 20 courses th
ii. 5 Edition – 2006/2007 17 courses th iii. 6 Edition – 2007/2008 19 courses iv. 7th Edition – 2008/2009 17 courses b. Number of professors of the programme i. 4th Edition – 2005/2006 47 national teachers 54 foreign teachers ii. 5th Edition – 2006/2007 53 national teachers 38 foreign teachers iii. 6th Edition – 2007/2008 47 foreign teachers 73 national teachers c.
Number of seminars i. 2005 ‐ 35 seminars ii. 2006 ‐ 27 seminars iii. 2007 ‐ 37 seminars iv. 2008 ‐ 42 seminars d. Number of students that benefit from the Programme i. Programme students 71 students ii. Non‐programme CNC PhD students 2005 – 97 students 2006 ‐ 112 students iii. Masters in Cell Biology 2005/06 ‐ 24 students 2006/07 ‐ 20 students e. Number of thesis i. 10 concluded and 2 expected to conclude within the present year f. Number of publications i. 46 papers in international peer‐reviewed journals 9|Página
3. Organization of PDBEB The programme includes advanced courses in top research areas, taught by foreign scientists in collaboration with local investigators, laboratory rotations and research work to be carried out within international networks organized by CNC. Each year a call for applications to the programme has been advertised at national newspapers and at the webpage of the programme (http://cnc.cj.uc.pt/BEB/). Near 100 applicants have applied each year for the doctoral programme, including applicants from abroad, from Coimbra, from Lisbon, Porto, Aveiro, Beira Interior, Algarve, Açores, Évora, and Bragança. The applicants were evaluated by a committee formed by Faculty members of CNC. The committee first evaluated the applicants on the basis of their Curriculum Vitae, through a careful analysis of their academic marks and quality of publications in order to select part of the applicants for interview. Twelve (12) applicants were finally selected each year. Criteria such as the ability to expose their current/past scientific work in a hypothesis‐driven manner, the scientific international experience, the motivation for carrying out an international scientific career, together with the academic merit, were taken into account for the final decision. The students went through a coursetraining period from October to April, in a total of 17 to 20 courses depending of the year (see programme of the courses) and around 40 seminars. Most of the courses were carried out in Coimbra. Ocasionnaly students also did one course at IGC (Oeiras) and IBMC (Porto). The 12 students also attended the Joint Meeting of Graduate Programme on Biosciences and the Annual Meeting of CNC, Portugal, which was held in Cantanhede, Biocant Park, December 16‐17, 2006. The students had the chance to evaluate all the courses and did laboratory rotations at CNC (6 weeks in the last edition and variable on prevous editions). After the course programme, students selected their areas of research and started working on their PhD projects. In previous editions the students have been encouraged to design with their national and foreign supervisors projects that involve collaborations between national and foreign laboratories, an approach that has been made mandatory since 2006. The aim is to promote development of high level thesis, promote networking and internationalization of national 10 | P á g i n a
laboratories, allowing the students to maintain ties with the national institutions that will allow them to work in our country after finishing their PhDs. Each year the students attend an annual meeting where they present their work. After four years the thesis is presented at the University of Coimbra. The students considered the past editions as Excellent, based on the organization of the programme of the courses, the high quality of the international and national lecturers specifically invited for teaching the courses. Furthermore, both coordinators and lecturers were impressed with the overall high quality of the students, highly contributing for maintaining the excellence and success of the Doctoral Programme in Experimental Biology and Biomedicine. Outline of Organization: „
Each year, twelve (12) students selected to the PDBEB (http://cnc.cj.uc.pt/BEB/) „
The Ph.D. degree ‐ the University of Coimbra, Faculties of Sciences and Technology, Pharmacy or Medicine. „
During the first year – 17‐20 courses and seminar programme „
Lab Rotation ‐ one month for students to become familiar with work at laboratories at CNC. „
Submission of the PhD project until the end of June „
Supervisors‐ at the University of Coimbra and an external supervisor, usually from abroad „
The project‐ collaboration between a national laboratory (from Center for Neuroscience and Cell Biology or other national laboratory) and an institute/laboratory abroad „
Attendance to the Annual meeting organized by CNC. 11 | P á g i n a
4. Courses Each year the programme provides, for the first year students, 16 to 20 advanced courses (1 week long) taught by foreign leading scientists in their fields, in collaboration with local investigators. The 4th and 5th Editions of the programme included 20 and 17 advanced courses, respectively. The courses were also attended by local graduate students and researchers and people from other Portuguese Universities. List of Courses: Advanced Courses | 4th Edition of PDBEB 73 October 2005 Molecular Biotechnology October 3‐7 Arthur Moir, Paula Veríssimo (Portugal), Isaura Simões (Portugal), Luisa Cortes (Portugal), Carlos Faro (Portugal), Euclides Pires (Portugal) Molecular and Cell Biology October 10‐14 J. Kevin Foskett (USA), Gergely Lukacs (Canada), Allen Volchuk (Canada), Carlos B. Duarte (Portugal) Microbiology October 24‐28 and November 2‐3 Fred Rainey (USA), Garo Antranikian (Alemanha), Pedro Lamosa (Portugal), Nuno Borges (Portugal) Milton Costa (Portugal), Nuno Empadinhas (Portugal) November 2005
Fertility November 7‐11 Justin St. John (UK), Christopher Navara (USA), Stefan Schlatt (USA), Olga Genlacev‐Krtolica (USA), João Ramalho‐Santos (Portugal) Biology of Development November 14‐18 Frieder Schoeck (Canada), Christine Hartmann (Austria), Ralph Ruebsam (Alemanha), João Ramalho‐
Santos (Portugal) Molecular Neuroscience November 28 – December 2 Andrew Irving (UK), Christopher Connoly (UK), Stuart Cobb (UK), Ana Luisa Carvalho (Portugal). 12 | P á g i n a
December 2005
Neuroinflammation December 5‐9 Jiang‐Fan Chen (USA), Bente Finsen (Dinamarca), Michail Sitkovsky (USA), Rodrigo Cunha (Portugal) Neurodegenerative Disorders December 12‐16 Henry Paulson (USA), Nicole Deglon (França), Maria Björkqvist (Suécia), Ana Luísa Carvalho (Portugal), Patrícia Maciel (Portugal), Sandra Ribeiro (Portugal), A. Cristina Rego (Portugal), Luís Pereira de Almeida (Portugal) January 2006
Neurosystems January 9‐13 Miguel Castelo‐Branco (Portugal), Louis Toth (USA), Elia Formisano (Netherlands), Rui Costa (USA) Neuromodulation January 16‐20 João O. Malva (Portugal), Ana P. Silva (Portugal), Armando Cristóvão (Portugal), Christophe Mulle (France), William Colmers (Canada), Rosa Cossart (France) Mini‐Course: Biostatistics January 23‐25 Pedro Anastácio (Portugal) February 2006
Structural Biology: Amyloidosis February 6‐10 Rui Brito (Portugal), Sandra Ribeiro (Portugal), Daniel A. Kirschner (USA), Sheena E. Radford (UK), Steven Finkbeiner (USA) Immunology February 13‐17 Celeste Lopes (Portugal), Teresa Cruz (Portugal), Alexandrina F. Mendes (Portugal), Kai Zacharowski (Germany), Anabela Cordeiro da Silva (Portugal), Carmen Garcia‐Rodriguez (Spain) Genetics of the Nucleus February 20‐24 Isabel Marques Carreira (Portugal) Catarina Resende de Oliveira (Portugal), Maj A. Hultén (UK), Thomas Liehr (Germany) March 2006
Biology of Proteolysis March 6‐10 Paulo Pereira (Portugal), David J Katzmann (USA), Randy Hampton (USA), Robert C Piper (USA) 13 | P á g i n a
Cancer Gene Therapy March 14‐17 Conceição Pedroso‐Lima (Portugal), Sérgio Simões (Portugal), João Nuno Moreira (Portugal), Esther Chang (USA) , Mirco Ponzoni (Italy) Toxicology: Anticancer therapy March 22‐24 Paulo Oliveira (Portugal), Leonor Almeida (Portugal), Carlos Palmeira (Portugal), João Laranjinha (Portugal), Sten Orrenius (Sweden), Catherine Brenner (France), Ulf Rapp (Germany), Jon Holy (USA) Diabetes and Vascular Disease March 27‐31 Raquel Seiça (Portugal), Cristina Sena (Portugal), María Molsalve (Spain), Fausta Natella (Italy), Michael Boarder (UK), Franscisco Ambrósio (Portugal), Sérgio Lemos (Portugal) April 2006
Toxicology of Nitric Oxide April 10‐13 João Laranjinha (Portugal), Rafael Radi (Uruguay), Ana Denicola (URUGUAY), Homero Rubbo (Uruguay) Functional Genomics April 17‐21 Paulo Santos (Portugal), Stephen Bustin (UK), Jo Vandesompele (Belgium), Katja Kotsch (Germany), José Cabeda (Portugal) 14 | P á g i n a
Advanced Courses | 5th Edition of PDBEB October 2006
Structural Biology October 9‐13 Ulrich Baumann (Switzerland), Christina Redfield (UK), Rui Brito (Portugal), Sandra Ribeiro (Portugal) November 2006
Molecular Cell Biology November 27 ‐ December 01 Carlos Duarte (Portugal) Gregg G. Gundersen (USA) , Geri Kreitzer (USA), Edgar R. Gomes (USA), Helder Maiato (Portugal) December 2006
Development Biology December 04‐07 Pedro Domingos (USA), Rui Martinho (Portugal), Antonio Jacinto (Portugal), Josh Brickman (Scotland), Leonor Saude (Portugal), José António Belo (Portugal), Moises Mallo (Portugal), Guillermina López‐Bendito (Spain) Reproductive Biology December 11‐15 João Ramalho‐Santos (Portugal), Christopher Navara (USA), António Granado (Portugal) January 2007
Biostatistics January 10‐12 Pedro Anastácio Death and Survival Signaling January 15‐19 Armanda Santos, Emília Duarte and Paulo Santos, Lloyd Greene, Alun Davies, Leonidas Stefanis Neurodegenerative diseases January 22‐26 Paula Agostinho, Claudia Pereira, Cristina Reg, Luis Almeida, Olga Corti, Ruth Luthi‐Carter, Salvatore Oddo Neurogenesis and Neural Stem Cells January 29 ‐ February 02 Inês Araújo, Cristina Rego, Allison Ebert, Mónica Sousa, Jia‐Yi Li, João Bettencourt Relvas 15 | P á g i n a
February 2007
Systems Neuroscience February 05‐09 Miguel Castelo‐Branco, Rui Costa, Marta Moita, Rainer Goebel, Serge Picaud Immunology February 19‐23 Alexandrina Mendes, Teresa Cruz, Celeste Lopes, Anabela Cordeiro Silva, António Bandeiras, Kai Zacharowski, Carmen Garcia‐Rodriguez NMR
February 26 ‐ March 02 Carlos Geraldes, Margarida Castro, Rui Carvalho, John Jones, Bernardo Celda, Shawn Burgess, Silvio Aime March 2007
Microbiology March 05‐09 Milton Costa, Nuno Empadinhas, André Antunes, Paula Morais, Teresa Gonçalves, António Veríssimo Gregor Grass, Fred Rainey Toxicology March 21‐23 Paulo Oliveira, João Laranjinha, Leonor Almeida, João Ramalho‐Santos, Sérgio Dias, Ernest Arenas, Horst Spielmann, Edward Perkins Molecular Biotechnology March 26‐30 Paula Veríssimo, Luísa Cortes April 2007
Oncobiology April 02‐06 Celeste Lopes, Teresa Martins, Alexandra Brás, Paula Soares, Raquel Seruca, Alberto Orfão Bioinformatics April 11‐13 Armindo Salvador, José Leal, Rui Alves, Ralf Hofestadt, Thoralf Topel Modelling of Biological Systems April 16‐20 Armindo Salvador, Rui Alves, Jorge Carneiro, Michael Savageau 16 | P á g i n a
Advanced Courses | 6th Edition of PDBEB October 2007
Molecular Biotechnology October 1‐12 Paula Veríssimo, Luísa Cortes, Bruno Manadas, Mónica Sousa Biostatistics October 3‐5 Pedro Anastácio and Isabel Gordo Lab Rotations October 15 to November 9 November 2007
Molecular Cell Biology November 12 to 16 Carlos Duarte, Edgar R. Gomes Transcription & RNA Biology November 19 to 20 Sukalyan Chatterjee Biology of RNA November 21 to 23 Manuel Santos Break November 26 to 30 December 2007
Reproductive Biology December 3 to 7 João Ramalho‐Santos Development Biology December 10 to 14 Sofia Araújo Meeting PDBEB December 20 to 21 17 | P á g i n a
January 2008
Proteolysis January 7 to 11 Paulo Pereira Molecular Neuroscience January 14 to 18 Ana Luisa Carvalho Cell Death January 21 to 25 Armanda Santos Neurodegenerative Disorders January 28 to 1st February Ana C. Rego, Cláudia Pereira, Luís P. Almeida, Paula Agostinho, Paula Moreira, Sandra M. Cardoso February 2008
Retinal Physiology and Disease: from Bench to Clinics February 4 to 8 Miguel Castelo‐Branco, Francisco Ambrósio Immunology February 11 to 15 Anabela C. Silva, M. Celeste Lopes, Sukalyan Chatterjee Microbiology February 18 to 22 Milton Costa Genome Biology February 25 to 27 Isabel Carreira March 2008
Synapse, Circuitry and Behavior March 3 to 7 Chinfei Chen, Guoping Feng Oncobiology March 10 to 14 Anália do Carmo, Maria Celeste Lopes, Sukalyan Chaterjee 18 | P á g i n a
Neuroimunology March 31 to April 3 Anália Carmo, Teresa Cruz, Emília Duarte April 2008
Extra‐activities April 7 Toxicology April 9 to 11 João Laranjinha, Leonor Almeida, Paulo Oliveira, Carlos Palmeira 19 | P á g i n a
Advanced Courses | 7th Edition of PDBEB September 2008 Biostatistics September 30 ‐ October 3 Chris Palmer October 2008 Molecular Biotechnology October 6‐17 Paula Veríssimo Lab Rotations October 20 ‐ November 14 November 2008 Molecular Cell Biology November 17‐21 Edgar Gomes Biology of Proteolysis November 24‐28 Sandra M. Cardoso, Cláudia Pereira, Paulo Pereira December 2008
Cell Biology of Infection December 3‐5 Otília Vieira Biology of Reproduction and Embryonic Stem Cells December 8‐12 João Ramalho Science Writing December 15‐16 Sofia Araújo CNC Annual Meeting December 16‐17 January 2009
Microbiology January 5‐9 Nuno Empadinhas 20 | P á g i n a
Immunobiology (Optional Course) January 12‐16 Celeste Lopes Neuroscience January 19‐22 Robrigo Cunha Cell Death January 26‐30 Armanda Santos February 2009
PRINCIPLES AND PRACTICE IN DRUG DEVELOPMENT (Optional Course) February 2‐13 João Nuno Moreira, Conceição Pedroso de Lima, Sérgio Simões, Luís Almeida Visual Neuroscience (Optional Course) February 9‐13 Miguel Castelo‐Branco Neurodegenerative Disorders February 16‐20 Ana Cristina Rego, Paula Agostinho, Cláudia Pereira, Luís Pereira de Almeida Vascular Physiology February 25‐27 João Laranjinha, Giovanni Mann, Paul Frazer March 2009 Biomedical Imaging and Metabolism March 2‐6 Carlos Geraldes Obesity & Type II Diabetes (Optional Course) March 9‐13 John Jones and Eugénia Carvalho Oncobiology March 16‐20 Anália Carmo, João Nuno Moreira Neurogenesis March 23‐27 João Malva April 2009
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5. Seminars PDBEB helds a weekly seminar programme open to the whole CNC and the scientific community which is attended by PDBEB students and local graduate students and researchers. Generally seminars are held on Friday afternoons and are given either by the invited professors that teach the courses during the week or by invited foreign and national researchers, when no courses are held on that week. 2005 Series | Friday 16:00 h
January 14 Titration of cellular processes with steady‐state concentrations of H2O2: advantages over the bolus addition approach Fernando Antunes Instituto de Investigação Científica Bento da Rocha Cabral e Centro de Química e Bioquímica da FCUL 21 Celular consequences of amyloid deposition in familial amyloid polyneuropathy Maria João Saraiva Amyloid Unit, Inst Biol Mol & Celular, Univ. Porto 28 From HIV to AIDS ‐ 22 years later! Prof. Krystyna Konopka Department of Microbiology, University of the Pacific, Arthur A. Dugoni School of Dentistry, San Francisco, USA February 4 Microbiology of Martian Environmental Analogs on Earth Fred A. Rainey Dept.Biological Sciences, Louisiana State University, Baton Rouge, Louisiana, USA 18 Role of nitric oxide in endothelial cell migration: a case for matrix metalloproteinase‐13 Santiago Lamas Centro Nacional de Investigaciones Cardiovasculares, Madrid 23 Joys and woes of AAV vectors for cardiovascular gene therapy Mauro Giacca International Centre for Genetic Engineering and Biotechnology – ICGEB Trieste, Italy 25 Cellular HATs: new emerging partners of HIV‐1 Anna Cereseto Scuola Normale Superiore in Pisa, Italy 22 | P á g i n a
March 4 Fluxes in Metabolic Networks of the Liver by NMR Craig R. Malloy University of Texas Southwestern Medical Center and Dallas VA Medical Center ‐ Dallas, Texas, USA Magnetic Resonance Contrast Agents for Molecular Imaging Applications Silvio Aime Dipartimento di Chimica Universitá degli studi di Torino, Italy 75 11 Novel approaches to monitor and manipulate single neurons in vivo Michael Brecht Department of Neuroscience Erasmus MC Rotterdam , The Netherlands 18 Regulation of intracellular protein degradation by the ubiquitin‐proteasome system George N. DeMartino Department of Physiology Southwestern Medical Center at Dallas – The University of Texas, USA April 1 Apoptosis in yeast: from biology to medical applications Paula Ludovico Instituto de Investigação em Ciências da Vida e Saúde Escola de Ciências da Saúde Universidade do Minho Braga, Portugal 8 Controlling signal transduction in T cells: inhibitors disguised of activators Alexandre Carmo IBMC, University of Porto 15 Manipulating immune responses: NFAT transcription factor as a target Carmen Garcia Instituto de Biología y Genética Molecular (CSIC‐Univ. de Valladolid), Facultad de Medicina Valladolid‐
SPAIN 22 Astrocytes and Neuroprotection/Neurodegeneration Simon Heales Neurometabolic Unit, National Hospital & Institute of Neurology (UCL), London, UK 29 Aging, a mitochondria‐mediated atavistic program. Can it be switched off? Vladimir Skulachev Moscow State University, Russia May 6 Neuropeptide Y and seizures Prof. Woldbye Laboratory of Neuropsychiatry, Rigshospitalet University Hospital & Department of Pharmacology, University of Copenhagen 23 | P á g i n a
12 Prions and Lipid Membranes Teresa Pinheiro Department of Biological Sciences, University of Warwick, UK 20 LentiVector‐based gene therapy for Parkinsonʹs disease and motor neuron diseases Mimoun Azzouz Oxford Biomedica plc Medawar Centre The Oxford Science Park, Oxford, UK 76 27 Dissecting the molecular mechanisms of neurotoxicity by unconjugated bilirubin Dora Brites Centro de Patogénese Molecular, Faculdade de Farmácia, Universidade de Lisboa June 3 Retinal gene expression in an experimental model for glaucoma. Microarray and real‐time quantitative PCR studies Willem Kamphuis Ophtalmic Research Institute, Amsterdam, The Netherlands 17 Huseyin Mehmet Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College, London, UK 24 Synucleins in Parkinsonʹs disease: novel insights Cristine Alves da Costa Institut de Pharmacologie Moléculaire et Cellulaire, IPMC, CNRS, Valbonne, France July 1 Proteomics‐driven research in neurodegeneration Michael Fountoulakis Foundation for Biomedical Research of the Academy of Athens, Greece October 7 A Review of The Role of The Sarcomeric Proteins in Familial Hypertrophic Cardiomyopathy Arthur Moir Krebs Institute, Department of Molecular Biology and Biotechnology, University of Sheffield, UK 14 The IP 3 receptor and the endoplasmic reticulum gateway to apoptosis Kevin Foskett University of Pennsylvania School of Medicine Departments of Physiology and Cell and Developmental Biology, Philadelphia, Pennsylvania USA 21 mRNA mistranslation in biological processes Manuel Santos Department of Biology, University of Aveiro, Portugal 24 | P á g i n a
28 Microbiology of Mars Analogs Fred A. Rainey Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana, USA November 3 Biocatalysis under extreme conditions; harvesting the potential of extremophiles Garo Antranikian Technical Microbiology, Technical University of Hamburg‐Harburg, Hamburg 11 Aneuploidy and mitotic spindle defects in in vitro fertilized embryos, somatic cell nuclear transfer embryos and embryonic stem cells Christopher Navara University of Pittsburgh, USA 18 A genome‐wide screen for genes affecting integrin‐mediated cell spreading Frieder Schoeck McGill University, Canada 25 Bioactivaction of xenobiotics and the expression of toxicity Maria de Lourdes Bastos Dep. Toxicologia, Faculdade de Farmácia, Universidade do Porto 30 Cannabinoid receptor dynamics Andrew Irving Neurosciences Institute, Dept. Pathology and Neuroscience, University of Dundee, UK December 9 Physiological control of immune response and inflammatory tissue damage by hypoxia‐
inducible factors and adenosine A2A receptors Michail V. Sitkovsky New England Inflammation and Tissue Protection Institute, Northeastern University, Boston , USA 16 Toward understanding pathogenesis of Machado‐Joseph disease Henry Paulson Carver College of Medicine, University of Iowa, Iowa City, IA, USA 78 2006 Series | Friday 16:00 h
January 13 Pharmacogenetic approaches to study cognitive and sensorimotor dysfunction Rui M. Costa Dept. of Neurobiology, Duke University Medical Center, Durham NC, USA 20 Spikes and Snacks: The Electrophysiology of Obesity William Colmers Department of Pharmacology University of Alberta, Edmonton, Canada 25 | P á g i n a
February 17 Negative regulation of Toll‐like receptors. Implications in atherogenesis Carmen García‐Rodríguez Instituto de Biología y Genética Molecular (CSIC‐UVA), Facultad de Medicina, Universidad de Valladolid, Espana 24 When are chromosomes, chromosomes? Thomas Liehr Institut fur Humangenetik und Anthropologie, Jena, Germany March 10 Regulation of multivesicular body cargo recognition and sorting David J. Katzmann Mayo Clinic Colege of Medicine, Rochester, MN, USA 17 Tumor vascular technology: a new therapeutic strategy for cancer Mirco Ponzoni Differentiation Therapy Unit Laboratory of Oncology G. Gaslini Childrenʹs Hospital Genoa, Italy 24 Mitochondria, oxidative stress and apoptosis Sten Orrenius Karolinska Institute, Sweden 30 Regulation of vascular endothelial cells by receptors (15:00 h) Michael Boarder Leicester School of Pharmacy De Montfort University Leicester, England 31 Molecular and cellular cognition: memory and how it fails Alcino J. Silva Departments of Neurobiology, Psychiatry and Biobehavioral Sciences, Psychology and Brain Research Institute, UCLA Los Angeles, USA April 7 Real‐time detection of fatty acid synthesis and TCA‐cycle anaplerosis in cultured human glioma cells with 13C NMR spectroscopy Anthony Mancuso The University of Pennsylvania, USA 13 Nitric Oxide‐derived oxidants, mitochondria and apoptotic signalling Rafel Radi School Medicine, Univ. Mentevideo, Uruguay 21 Laser capture microdissection and real‐time PCR analysis in biomedical sciences Stephen A. Bustin Barts and the London Queen Maryʹs School of Medicine and Dentistry, University of London, UK. 26 | P á g i n a
28 From Mad Cows to Neurotic Yeast, and Back: Molecular Approaches for Studying Neurodegenerative Diseases Tiago Fleming Outeiro Mass General Institute for Neurodegenerative Disease‐ MIND Harvard Medical School Charlestown, USA May 3 Plasmodium ‐ Hepatocyte interactions: implications for protection against Malaria Patricia R.S. Leirião Instituto Gulbenkian de Ciência / Instituto de Medicina Molecular 4 The protective/toxic effects of four flavonoids on hepatic mitochondria ‐ Possible relevance for cancer development Daniel J. Dorta Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Brasil 5 Embryoid bodies as models for studying embryonic hematopoiesis Leonor Parreira Instituto de Medicina Molecular Faculdade de Medicina de Lisboa, Lisboa, Portugal October 13 Using NMR to study calcium binding in modular proteins containing epidermal growth factor‐like (EGF) domains Christina Redfield Department of Biochemistry, University of Oxford , U.K. 20 Plasmodium and its host ‐ how good is their interaction? Maria Mota Institute of Molecular Medicine, Lisbon 27 Metabolomics and Biomarkers in the Context of Inborn Errors of Metabolism Isabel Tavares de Almeida Centro de Patogénese Molecular, Faculdade de Farmácia, Universidade de Lisboa November 3 Cardiac Mitochondrial Toxicity of Antineoplastic Agents Paulo Oliveira Centre for Neuroscience and Cell Biology, Coimbra 10 Stem cells from the subventricular zone (SVZ) of the adult brain: source of new neurons for brain repair? Fabienne Agasse Centre for Neuroscience and Cell Biology | Instituto de Bioquimica, Universidade de Coimbra 16 Die or Survive? Molecular Mechanisms of Bile Acid Effects Cecília Rodrigues Centro de Patogénese Molecular, Faculdade de Farmácia, Universidade de Lisboa 27 | P á g i n a
24 The apical membrane and ciliogenesis in polarized epithelial cells: is there a connection? Otília Vieira Centro de Neurociências e Biologia Celular, Coimbra 29 Functional Analysis of Kinesins during Epithelial Polarization Geri Kreitzer Dept. of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, USA December 6 Mechanisms of Axon Guidance: How to get to the right place Gulillermina Lopez Bendito Instituto de NeurocienciasCSIC‐Universidad Miguel Hernández, Campus de San Juan, San Juan de Alicante, Spain 14 Modulation of ion channels by changes in lipid composition , exogenous compounds, and osmotic pressure gradients Sid Simon Department of Neurobiology, Duke University Medical Center Durham, U.S.A. 15 Do human embryonic stem cells disregulate the cell cycle, similar to early cancer cells? Christopher Navara Pittsburgh Development Center, University of Pittsburgh, USA 2007 Series | Friday 16:00 h
January 19 How do neurons die in neurodegenerative disorders and how can we prevent this? Insights from cellular models. Lloyd Greene Columbia University Medical Center, New York, USA 26 From Parkin gene mutations to Parkinson’s disease: Pieces of the puzzle Olga Corti INSERM U679 ‐ Thérapeutique et Neurologie Expérimentale Hôpital de la Pitié‐Salpêtriére, Paris, France February 2 Application of neural stem cells for brain repair in neurodegenerative disorders – the case of Parkinson’s and Huntington’s disease Jia‐Yi Li Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden 9 Neural mechanisms underlying associative plasticity during auditory fear conditioning Marta Moita Gulbenkian Institute for Science, Oeiras, Portugal 28 | P á g i n a
16 Revisiting excitotoxicity: new insights into neuronal Ca2+ dynamics Inês Araújo Centro de Neurociências e Biologia Celular, Coimbra 23 Inflammation in the pathogenesis of cardiovascular diseases: new pharmacological approaches Kai Zacharowski Dept. of Anaesthesia, BHI Bristol Royal Infirmary, Bristol, UK 27 Core metabolism during cell proliferation: how do cells make more cells? Ralph DeBerardinis Abramson Family Cancer Research Institute, The University of Pennsylvania, USA March 2 Magnetic Resonance Contrast Agents for Molecular Imaging Applications Silvio Aime Chemistry Department and Center for Molecular Imaging, University of Torino, Torino, Italy 9 Desiccation and ionizing radiation resistance: Adaptations to life in arid environments Fred Rainey Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana, USA 16 The role of the endocannabinoid system in neuronal communication and metabolism Attila Köfalvi Center for Neurosciences of Coimbra, and Instituto de Investigação Interdisciplinar, University of Coimbra 23 Stem cells and Parkinsonʹs disease Ernest Arenas Karolinska Institute, Sweden 30 Functional genomics studies of endocytosis and signalling Marino Zerial Max‐Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany April 4 Peptide‐based delivery of nucleic acids Bernard Lebleu UMR 5235 CNRS, Université Montpellier 2 4 Diagnosis and follow‐up of B‐chronic lymphoproliferative disorders by flow cytometry immunophenotyping Alberto Orfão Department of Medicine, Cytometry Service and Cancer Research Centre, University of Salamanca, Salamanca, Spain 13 Metabolic network analysis and the detection of inborn errors Ralf Hofestadt Institute of Bioinformatics and Medical Informatics, University Bielefeld (Germany) 29 | P á g i n a
18 Mechanisms of protein tyrosine nitration in hydrophilic and hydrophobic biocompartments Rafael Radi Facultad de Medicina Universidad de la República Montevideo, Uruguay 20 Function design in the evolution of gene circuitry Michael A Savageau Department of Biomedical Engineering, University of California, Davis (USA) 27 El valor diagnstico de la Microscopia Electronica en Patologia Juan Cuevas Hospital Universitário, Santiago de Compostela, Espana May 4 Communication within and between cells to decide life and death Sukalyan Chaterjee Center for Neurosciences and Cell Biology, Coimbra 18 Applications of mass spectrometry in Biology: an introduction to proteomics Pedro Domingues Departamento de Química, Universidade de Aveiro ‐ Aveiro 25 Interleukin‐10 Underlies Distinct Susceptibilities to Mycobacterial Infections Margarida Correia Neves Escola de Ciências da Saúde ‐ Instituto de Investigação em Ciências da Vida e Saúde Universidade do Minho 28 Dissection of the components for PIP2 activation and thermosensation in TRP channels | Fac. Medicina, Sala Química Fisológica (R/C) ‐ 14:30 Ramon Latorre Department of Biophysics, Centro de Estudios Cientificos, Valdivia, Chile 31 Dipeptidylpeptidase IV inhibition: the reverse side of the coin Eric Grouzmann Division de Pharmacologie et Toxicology Centre Hospitalaire Universitaire Vaudois Lausanne, Switzerland June 1 Shared mechanisms during neural and tracheal morphogenesis in Drosophila melanogaster. Sofia Araújo Institut de Recerca Biomedica de Barcelona (IRBB) IBMB‐CSIC, Barcelona 15 Targeting angiogenesis by polyphenols. From Mechanisms to therapeutics Raquel Soares e Rita Araújo Serviço de Bioquímica, Faculdade de Medicina da Universidade do Porto, Porto 22 FLRT3 modulates FGF signalling during regeneration of the adult zebrafish caudal fin Nuno Afonso Instituto Gulbenkian de Ciência, Oeiras, Portugal 30 | P á g i n a
29 Unravelling the Molecular Basis of Parkinsonʹs Disease Tiago Fleming Outeiro Instituto de Medicina Molecular, Lisboa e MGH ‐ Harvard Medical School, USAl July 6 The role of superoxide in age‐related loss of skeletal muscle mass and function Malcolm Jackson Division of Metabolic and Cellular Medicine School of Clinical Sciences University of Liverpool 16 Biology of Huntingtonʹs disease and Parkinsonʹs disease Christopher A. Ross Division of Neurobiology, Baltimore HuntingtonʹsDisease, Center Johns Hopkins University School of Medicine, Baltimore, MD, USA 17 Oxidative Stress in Alzheimer Disease George Perry College of Sciences ‐The University of Texas at San Antonio 26 Neurotoxicity of methamphetamine Syed F. Ali Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/FDA Jefferson, AR, USA 2008 Series | Friday 16:00 h
January 11 Regulation of Proteasome Activity | Auditório do IBILI ‐ Pólo III Daniel Finley Department of Cell Biology, Harvard Medical School, Boston, USA 17 Assembly and plasticity of hippocampal synapses | Thursday, 16:00 h | Auditório do IBILI ‐ Pólo III Ann Marie Craig Brain Research Centre | Department of Psychiatry University of British Columbia | Vancouver, BC, Canada 25 The role of AP‐1 transcription factors and their target genes in developmental neuronal death | Auditório do IBILI ‐ Pólo III Jonathan Ham Molecular Haematology and Cancer Biology Unit, | Camelia Botnar Laboratories Institute of Child Health | University College London | London WC1N 1EH, UK 31 | P á g i n a
February 1 Protein misfolding disorders – mechanisms of protein aggregation and toxicity David Borchelt Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL, USA 8 Regulation of synaptic transmission through presynaptic glutamate transporters in the retina Espen Hartveit Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009 Bergen Norway 15 Role of invariant Natural Killer T cells in airway inflammations: foccus on allergic asthma | 11:30 Maria do Carmo Leite‐de‐Moraes CNRS, Faculté de Médecine, René Descartes, Paris V, Hôpital Necker, Paris 15 Analysis of DNA binding site motifs in Saccharomyces cerevisiae using the YEASTRACT‐
DISCOVERER tools | Extra seminar Feb. 15, 15:00. Chemistry Department, 2nd floor seminar room | Ana Teresa Freitas, IST and INESC 19 Mitochondrial Permeabilization in Necrosis, Apoptotis and Autophagy | Extra Seminar | Tuesday, 17:00 | Anfiteatro de Zoologia John J. Lemasters Medical University of South Carolina, USA 22 The Microbe Hunters: The Search for new Taxa: From Species to Phyla Fred Rainey Louisiana State University, USA 29 Poised RNA polymerase II complexes in epigenetics and genome architecture Ana Pombo MRC, Imperial College, London March 7 Synaptic and Circuitry Mechanisms of Obsessive‐Compulsive Disorder‐like Behavior in Mice Guoping Feng Department of Neurobiology, Duke University Medical Center, USA 12 ʺBone marrow‐derived stem/progenitor cells control primary tumor growth, and initiation and progression of metastasis.ʺ| Wednesday, 16:00 Vivek Mittal Cold Spring Harbor Laboratory | New York, USA 32 | P á g i n a
April 3 Glutamate and glutamate receptors at the Immunosynapse Denis Soulet Dept. of Experimental Medical Science, Lund University, Sweden 4 Transcriptional activation of redox sensitive genes in vascular endothelial and smooth muscle cells Giovanni Mann Cardiovascular Division, School of Medicine King`s College London, U.K 4 Reactive oxygen species signaling in regulation of the blood‐brain barrier Paul Fraser Cardiovascular Division, School of Medicine King`s College London, U.K 11 Drug development and safety‐ past, present and future [Auditório da Reitoria | U.C.] Yvonne Will Early Safety Differentiation Group, Pfizer Groton, CT, USA May 9 Embryonic stem cells‐derived cardiomyocytes: functionality and tissue‐engineered strategies for heart regeneration Marisa Jaconi Dept. Pathology and Immunology, Faculty of Medicine, Geneva University 16 Prions : folding, aggregation and toxicity Teresa Pinheiro Dept. of Biological Sciences, University of Warwick Coventry United Kingdom June 6 Genetic dissection of the physiological functions of the endocannabinoid system Giovanni Marsicano AVENIR INSERM U862 ‐ NeuroCentre Magendie, Bordeux, France 13 Cells caught in the act: Morphodynamic imaging and modelling of living cells Jorge Carneiro Inst. Gulbenkian de Ciência, Oeiras, Portugal 33 | P á g i n a
16 Why Alzheimer is a disease of memory: the attack on synapses by Abeta oligomers William Klein Cognitine Neurology and Alzheimerʹs Disease Center, Northwestern University, USA 20 Different flavors of pluripotency Niels Geijsen Harvard Medical School, USA 24 Peroxynitrite decomposition catalysts and mitochondrial‐targeted antioxidants: its promising pharmacological action in neurodegenerative disorders (sala BEB) Rafael Radi 25 In search of the in vivo identity of mesenchymal stem cells (sala BEB) Nance Beyer, Nardi Department of Genetics, Universidade Federal do Rio Grande do Sul, Brazil 27 Biomarkers of Brain Tumorʹs Development, Progression and Therapeutic Response Rui Reis Life and Health Science Research Institute, University of Minho, Portugal July 10 Gene and cell therapy for tissue angiogenesis and myocardial regeneration | Thursday morning Mauro Giacca September 4 Targeting metabolic dysfunction in Huntingtonʹs disease | Anfiteatro Anatomia Patológica | 14:30 h | FMUC, 1st Floor 18 Gene loss in intracellular endosymbionts and parasites: sacrificing redundancy for diversity| FMUC 1st floor Luís Pereira Leal IGC Lisbon 19 Treating Experimental Arthritis by CD8 T cell Depletion| Sala Química Fisiologica 16:00H|FMUC Margarida Carneiro Instítuto GulbenKian de Ciência 26 Catalytic RNAs in Biomedicine| Sala Programa Doutoral |16:00h | FMUC,1stFloor Alexandre Ferreira IMM 34 | P á g i n a
October 17 Biological knowledge to refine breast cancer prognostication| Sala Programa Doutoral |16:00h | FMUC,1stFloor Benjamin Haibe‐Kains Computer Science Dept. Univ. Libre Bruxelles and Functional Genomics Unit, Jules Bordet Institute 30 BDNF mRNA splice variants: A spatial code to regulate local Plasticity of Dendrites and spines| Sala Fisiologia |16:00h | FMUC,1stFloor Enrico Tongiorgi Brain Centre for Neuroscience. Department of Biology at University Trieste, triest, Italy November 7 Molecular mechanisms of wound healing | Sala Programa Doutoral |16:00h | FMUC,1st Floor Eugénia Carvalho CNC – Centro de Neurociências e Biologia Celular 11| Sala Fisiologia |14:30h | FMUC,1st Floor Jan Motlik Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Czech Republic 20 Effect of Acetaminophen (Paracetamol) Hepatotoxicity on Expression and Regulation of Hepatobiliary Drug Transporters: Role of Oxidative Stress and Kupffer Cell Function
Sala Fisiologia |14:30h| FMUC,1st Floor 21 Integrating actin dynamics with adhesion in cell migration| Sala Programa Doutoral |16:00h | FMUC,1stFloor Clare M. Waterman Laboratory of Cell and Tissue Morphodynamics ?National, Heart, Lung and Blood Institute ?National Institutes of Health, Bethesda Maryland, USA 28 Pathophysiology of chaperone‐mediated autophagy| Sala Programa Doutoral |16:00h | FMUC,1stFloor Ana Maria Cuervo Albert Einstein College of Medicine, New York, USA 28 Dissecting neurological functions through gene transfer | Sala Programa Doutoral |16:00h | FMUC,1stFloor Nicole Déglon Atomic Energy Commission (CEA) Deputy Director Molecular Imaging Research Center (MIRCen) 35 | P á g i n a
December 4 Molecular dynamics and docking studies of ligands to Cytochrome P450 3A4 | Sala Programa Doutoral |16:00h | FMUC,1st Floor Paulo Martel Centro de Biomedicina Molecular e Estrutural IBB‐ Instituto Biotecnologia Bioengenharia, Universidade do Algarve 5 Unexpected fate and function of a single glycolipid in pigmentation| Sala Programa Doutoral |16:00h | FMUC,1st Floor Gerrit Van Meer Membrane Enzymology Bijvoet Center/Institute of Biomembranes Utrecht University, The Netherlands 12 Pluripotency Strategies and Sophisticated Non‐Invasive Imaging to Realize the Promises of Regenerative Medicin| Sala Programa Doutoral |16:00h | FMUC,1stFloor Gerald Schatten University of Pittsburgh, USA 15 Cationic lipid‐mediated delivery of genes and oligonucleotides into eukaryotic cells: mechanism and cellular barriers| Anfiteatro de Farmacologia |16:00h | FMUC, 2nd Floor Dick Hoekstra Faculty Medical Sciences, University of Groningen, The Netherlands 36 | P á g i n a
6. Teachers The courses are taught by foreign leading scientists in their fields, in collaboration with local investigators During the years 2005, 2006 and 2007 47 national and 54 foreign researchers taught at the course programme of the 4th Edition of the Programme, 53 national researchers and 38 researchers from abroad taught at the 5th edition of the programme and 73 national and 47 foreign researchers taught at the 6th edition. 2005-2006 | 4th Edition of PDBEB
Invited Faculty Member Department University Alexandrina Pinto Mendes Faculty of Pharmacy and CNC University of Coimbra Allen Volchuk Depart. Biochemistry University of Toronto Ana Denicola Lab. Físicoquímica Biológica Universidad de la República Ana Luísa Carvalho Depart. Zoology University of Coimbra Ana P. Silva Depart. Zoology University of Coimbra Anabela Cordeiro da Silva IBMC University of Porto Andrew Irving Division of Pathology/Neuroscience University of Dundee Armando Cristovão University of Coimbra Arthur Moir Depart. Zoology Depart. Molec. Biology Biotechnology Bente Finsen Depart. Anatomy and Neurobiology University of Sheffield Institute of Medical Biology, Odense University Carlos Duarte Depart. Zoology University of Coimbra Carlos Faro Depart. Biochemistry University of Coimbra Carlos M. Palmeira Depart. Zoology Instituto de Biologia y Genética Molecular (CSIC‐UVA) University of Coimbra Carmen Garcia‐Rodriguez Catarina Resende Oliveira Catherine Brenner Christine Hartmann Depart. Biochemistry Centre National de la Recherche Scientifique University of Valladolid University of Coimbra Université de Versailles Research Institute for Molecular Pathology Christophe Mulle Depart. Physiologie Cellulaire de la Synapse Christopher Connolly Division of Pathology/Neuroscience University of Dundee Christopher Navara Depart. Of Obstetrics University of Pittsburgh Cristina Rego Depart. Biochemistry University of Coimbra Cristina Sena Depart. Of Physiology University of Coimbra Daniel A. Kirschner Boston College Depart. Of Biochemistry and Molecular Biology University of Harvard Maastricht University Esther Chang Dep.of Cognitive Neuroscience National Foundation for Cancer Research Euclides Pires Depart. Biochemistry Fausta Natella David J Katzmann Elia Formisano Université Bordeaux 2 Mayo Clinic College of Medicine University of Georgetown University of Coimbra National Institute for Food and Nutrition Research 37 | P á g i n a
Francisco Ambrósio Depart. Of Biophysics and Biomathematics University of Coimbra Fred Rainey Depart. Of Biological Sciences University of Waikato Frieder Schoeck Depart. Of Biology McGill University Garo Antranikian University of Hamburg Gergely L. Lukacs Hospital for Sick Children Henry L. Paulson Depart. Of Neurology University of Iowa Homero Rubbo Departamento de Bioquímica Universidad de la República Isabel Marques Carreira Institute of Medical Biology Isaura Simões Biocant University of Coimbra Parque Tecnológico de Cantanhede, Núcleo 4 ‐ Lote 3 J. Kevin Foskett Depart. Physiology University of Pennsylvania Jiang‐Fan Chen Depart. Neurology University of Bóston Jo Vandesompele Center for Medical Genetics Ghent Ghent University Hospital João Laranjinha Laboratory of Biochemistry University of Coimbra João Laranjinha Laboratory of Biochemistry University of Coimbra João Malva Depart. Biochemistry University of Coimbra João Nuno Moreira Faculty of Pharmacy and CNC University of Coimbra João Ramalho‐Santos Depart. Zoology Depart. Of Anatomy and Cell Biology University of Coimbra Jon Holy José Cabeda University of Minnesota Justin St. John Depart. Molecular Biology Unit Division of Medical Sciences ‐ The Medical School Kai Zacharowski Depart. Of Anesthesia University Hospital of Dusseldorf Katja Kotsch Institute of Medical Immunology Universitätsmedizin Charité Leonor M. Almeida Laboratory of Biochemistry University of Coimbra Louis Toth School of Medicine University of Boston Luís Pereira Almeida University of Coimbra Luísa Cortes Center for Neuroscience and Cell Biology ‐ IBILI University of Coimbra M.ª Celeste Lopes Faculty of Pharmacy and CNC University of Coimbra M.ª Conceição Pedroso Lima Depart. Biochemistry and CNC University of Coimbra M.ª Teresa Cruz Rosete Faculty of Pharmacy and CNC University of Coimbra Maj A. Hultén University of Warwick Maria Bjorkqvist Depart. Of Biological Sciences Depart. Of Experimental Medical Sciences María Molsave University of Lund Fundación Centro Nacional de Investigaciones Michael Boarder Depart. Of Pharmacology University of Montfort Michail V. Sitkovsky Laboratory of Immunology University of Northeastern Miguel Castelo‐Branco Visual Neuroscience Laboratory University of Coimbra Milton Costa University of Coimbra University of Genoa Nicole Deglon Depart. Bioquímica ‐ CNC Istituto Nazionale per la Ricerca Sul Cancro Depart. Of Medical Research and Imagene Program Nuno Borges Cell Physiology and NMR Group ITQB ‐ University New of Lisbon Nuno Empadinhas Depart. Bioquímica ‐ CNC University of Coimbra Olga Genbacev‐Krtolica UCSF Medical School, Dean`s Office University of San Francisco Mirco Ponzoni Hospital Santo António University of Birmingham Atomic Energy Commission (CEA) 38 | P á g i n a
Patrícia Maciel Health School of Sciences University of Minho Paula Verissimo Depart. Biochemistry University of Coimbra Paulo Oliveira Depart. Zoology University of Coimbra Paulo Pereira University of Coimbra Paulo Santos Visual Neuroscience Laboratory Center for Histocompatiblity of the Centre Coimbra Pedro Anastácio Depart. Of Ecology University of Évora Pedro Lamosa Cell Physiology and NMR University New of Lisbon Rafael Radi Departamento de Bioquímica Universidad de la República Ralph Ruebsam Depart. Of Development Biology Depart. Of Cell and Developmental Biology University of Erlangen‐Nuremberg University of Coimbra Robert C Piper Depart. Of Physiology Depart. Of Physiology and Biophysics Rodrigo Cunha Depart. Biochemistry University of Coimbra Rosa Cossart Institut Neurobiologie de la Méditerranée Rui Brito Depart. Of Chemistry and CNC Randy Hampton Raquel Seiça University of California Unniversity of Iowa University of Coimbra Rui Costa Depart. Of Neurobiology Duke University Medical Center Sandra Macedo Ribeiro Instituto Biol. Molecular e Celular University of Porto Sergio Grinstein Research Institute of Toronto Hospital for Sick Children Sérgio Lemos Depart. Of Physiology University of Coimbra Sérgio Simões Faculty of Pharmacy and CNC Depart. Protein Folding and Misfolding Depart. Of Cell Biology and Physiology University of Coimbra Depart. Of Toxicology Institute of Cell and Molecular Science Institute of Environmental Medicine University of California, USA Ulf Rapp Institute of Neurological Diseases Division of Neuroscience and Biomedical Systems Institut fur Humangenetik und Anthropologie Institut fur Medizinische, Strahlenkunde und Zellforschung William Colmers Depart. Pharmacology Sheena E. Radford Stefan Schlatt Sten Orrenius Stephen A. Bustin Steven Finkbeiner Stuart Cobb Thomas Liehr University of Leeds University of Pittsburgh University of London University of Glasgow Jena Universitat Wurzburg University of Alberta 39 | P á g i n a
2006-2007 | 5th Edition of PDBEB
Invited Faculty Member Department University Alberto Orfão Department of Medicine, Cytometry Service and Cancer Research Centre Alexandra Brás Genomic Instability Group University of Salamanca Centro Nacional de Investigaciones Oncológicas Melchor Fernández Almagro 28029 Madrid Alexandrina Mendes Faculty of Pharmacy and CNC University of Coimbra Allison Ebert Waisman Center University of Wisconsin Alun Davies Cardiff School of Biosciences BIOSI 3 Ana Cristina Rego Universidade de Coimbra António Bandeiras Departamento de Bioquímica Institute of Molecular and Cellular Biology Center for Neuroscience and Cell Biology Centre National de la Recherche Scientifique, Unite de Recherche Associee 1961 António Granado Jornalista ʺ Ciência no Público ʺ Antonio Jacinto Instituto de Medicina Molecular Faculdade Medicina de Lisboa Department of Zoology and Center for Neuroscience and Cell Biology University of Coimbra Anabela Cordeiro Silva André Antunes António Veríssimo Armanda Santos University of Porto University of Coimbra Institut Pasteur Universidade Nova de Lisboa ‐ Docente de Jornalismo Bernardo Celda Faculdade de Farmácia Molecular Systems Biology Group, Centre for Neuroscience and Cell Biology, Chemistry Department Depart.of Physical Chemistry, Laboratory of Molecular Imaging Carlos Duarte Depart. Zoology University of Coimbra Carlos Geraldes Depart. Biochemistry Instituto de Biologia y Genética Molecular (CSIC‐UVA) University of Coimbra Armindo Salvador Carmen Garcia‐Rodriguez Universidade de Coimbra University of Coimbra University of Valencia University of Valladolid Celeste Lopes Faculty of Pharmacy and CNC University of Coimbra Christina Redfield Oxford Centre for Molecular Sciences University of Oxford Christopher Navara Depart. Of Obstetrics University of Pittsburgh Cláudia Pereira Departamento de Zoologia Universidade de Coimbra Edgar R. Gomes Department Pathology Columbia University 249 Medical School, D602, 1035 University Dr Edward Perkins UMD Biochem / Molecular Biology Emília Duarte Faculdade Ciências e Tecnologia Laboratory of Molecular Neurobiology, Dept. of Medical Biochemistry and Biophysics Karolinska Institute Geri Kreitzer Depart. Biological Sciences Dept. of Cell and Developmental Biology Louisiana State University Weill Medical College of Cornell University Gregg G. Gundersen Dept. Anatomy and Cell Biology Columbia University Gregor Grass Institute for Microbiology Martin‐Luther University Ernest Arenas Fred Rainey Universidade de Coimbra Guillermina López‐Bendito Instituto de Neurociencias CSIC ‐ Universidad Miguel Hernández Helder Maiato University of Porto Instituto Biol. Molecular e Celular 40 | P á g i n a
Horst Spielmann Department 3 ‐ Scientific Service Federal Institute for Risk Assessment Inês Araújo Jia‐Yi Li Faculdade Ciências e Tecnologia Neuronal Survival Unit, Dept. of Experimental Medical Science João Bettencourt Relvas Institute of Cell Biology Universidade de Coimbra Wallenberg Neuroscience Center, Lund University ETH Hoenggerberg, Schafmattstr.18, 8093 Zurich João Laranjinha João Ramalho‐Santos Laboratory of Biochemistry Department of Zoology / Center for Neuroscience and Cell Biology University of Coimbra John Jones Depart. Zoology University of Coimbra Jorge Carneiro Gulbenkian Institute of Science Apartado 14 José António Belo CBME/ FERN Universidade do Algarve José Leal Gulbenkian Institute of Science Rua da Quinta Grande, nº 6 Josh Brickman Institute for Stem Cell Research University of Edinburgh Kai Zacharowski Leonidas Stefanis Depart. Of Anesthesia Laboratory of Biology of Neurodegenerative Diseases University Hospital of Dusseldorf Foundation for Biomedical Research of Athens and University of Athens Leonor Almeida Laboratory of Biochemistry University of Coimbra Leonor Saúde Instituto Gulbenkian de Ciência Faculdade Medicina de Lisboa Lloyd Greene Dept. of Pathology Columbia University Medical Center Luís Pereira de Almeida Universidade de Coimbra Luísa Cortes Faculdade de Farmácia / CNC Center for Neuroscience and Cell Biology University of Coimbra Margarida Castro Depart. Biochemistry University of Coimbra Marta Moita Rua da Quinta Grande, nº 6 Michael Savageau Instituto Gulbenkian de Ciência College of Engineering, Dept. of Biomedical Engineering University of California Miguel Castelo‐Branco Visual Neuroscience Laboratory University of Coimbra Milton Costa Depart. Bioquímica ‐ CNC University of Coimbra Moises Mallo Instituto Gulbenkian de Ciência Instituto Biologia Molecular e Celular, IBMC Rua da Quinta Grande, nº 6 Depart. Bioquímica ‐ CNC INSERM U679 Thérapeutique et Neurologie Expérimentale University of Coimbra Universidade de Coimbra Paulo Oliveira Departamento de Zoologia Department of Biochemistry and Institute of Environment and Life Faculty of Medicine and Institute of Molecular Pathology and Immunology Center for Neuroscience and Cell Biology Mitochondrial Toxicology and Pharmacology Group, Center for Neurosciences and Cell Biology Paulo Santos Faculdade Ciências e Tecnologia Universidade de Coimbra Pedro Anastácio Depart. of Ecology Strang Laboratory of Apoptosis and Cancer Biology University of Évora Mónica Sousa Nuno Empadinhas Olga Corti Paula Agostinho Paula Morais Paula Soares Paula Veríssimo Pedro Domingos Rainer Goebel Ralf Hofestadt Dep.of Cognitive Neuroscience Faculty of Technology, Bioinformatics Department University of Coimbra Universidade do Porto Hôpitale de la Pitié‐Salpêtriére, Paris University of Coimbra University of Porto University of Coimbra University of Coimbra The Rockefeller University Maastricht University Bielefeld University 41 | P á g i n a
Rui Alves Faculty of Medicine and Institute of Molecular Pathology and Immunology University of Porto Departament de Ciències Médiques Básiques, Facultat de Medicina, Rovira Roure 44 Universidad de Lleida Rui Brito Depart. Of Chemistry and CNC University of Coimbra Rui Carvalho Depart. Biochemistry University of Coimbra Rui Costa Depart. Of Neurobiology Duke University Medical Center Rui Martinho Instituto Gulbenkian de Ciência Laboratoire de Neurogénomique Functionelle Laboratory of Molecular Neuropathogenesis Rua da Quinta Grande, nº 6 École Polytechnique Fédérale de Lausanne Instituto Biol. Molecular e Celular Laboratoire de Physiopathologie Cellulaire et Moleculaire de la Retine CIPM ‐ Portuguese Institute of Oncology ʺ Francisco Gentil ʺ The Mary Nell and Ralph B. Rogers Magnetic Resonance Center Depart. Of Chemistry and Center for Molecular Imaging University of Porto Raquel Seruca Ruth Luthi‐Carter Salvatore Oddo Sandra Ribeiro Serge Picaud Sérgio Dias Shawn Burgess Silvio Aime Teresa Cruz Teresa Gonçalves Teresa Martins Thoralf Topel Ulrich Baumann Faculty of Pharmacy and CNC Faculty of Medicine and Center for Neuroscience and Cell Biology IPO / Center for Neuroscience and Cell Biology Faculty of Technology, Bioinformatics Department Department of Chemistry & Biochemistry University of California Universite Pierre et Marie Curie Lisboa University of Texas University of Torino University of Coimbra University of Coimbra University of Coimbra Bielefeld University University of Berne 42 | P á g i n a
2007-2008 | 6th Edition of PDBEB
Invited Faculty Member Paula Veríssimo Department University Mónica Sousa Depart. Biochemistry Center for Neuroscience and Cell Biology Center for Neuroscience and Cell Biology Instituto Biologia Molecular e Celular IBMC Pedro Anastácio Depart. Of Ecology University of Évora Luísa Cortes Bruno Manadas University of Coimbra University of Coimbra University of Coimbra Universidade do Porto Isabel Gordo Instituto Gulbenkian de Ciência Carlos Duarte Depart. Zoology University of Coimbra Edgar R. Gomes Department Pathology Columbia University Phong Tran Cell Developmental Biology Max Planck Institute of Mol. Cell Biology and Genetics University of Pennsylvania Helder Maiato Instituto Biol. Molecular e Celular University of Porto Sukalyan Chatterjee Center for Neuroscience and Cell Biology University of Coimbra Manuel Santos Depart. Biology University of Aveiro João Ramalho‐Santos Depart. Of Zoology Maria De Miguel Eduardo Ruiz‐Pesini Hospital Universitario La Paz Departamento de Bioquímica, Biología Molecular y Celular University of Coimbra Universidad Autonoma de Madrid Miguel Ramalho‐Santos UCSF Diabetes Center University of California Sofia Araújo IRB Barcelona IBMB‐CSIC Rui Martinho Instituto Gulbenkian de Ciência Rua da Quinta Grande, nº 6 Leonor Saúde Instituto Gulbenkian de Ciência Faculdade Medicina de Lisboa António Jacinto Instituto de Medicina Molecular Faculdade Medicina de Lisboa Isabel Palmeirim Escola de Ciências da Saúde Ginés Morata Centro de Biologia Molecular University of Minho Universidad Autónoma de Madrid Richard Hampson Thelial Technologies Institut de Biologia Molecular de Barcelona ‐ CSIC MRC Centre for Developmental Neurobiology Ewa Paluch Dan Shaye Corinne Houart Hector Herranz Enrique Martin‐Blanco Icrea and Institut de Recerca Biomedica Institut de Biologia Molecular de Barcelona ‐ CSIC Dresden University of Zaragoza Portugal Parc Científic de Barcelona c/ Josep Samitier 1‐5 King´s College London, New Hunt`s House, 4th Floor Parc Científic de Barcelona c/ Josep Samitier 1‐5 Parc Científic de Barcelona c/ Josep Samitier 1‐5 Pedro Coutinho MRC Human Genetics Unit Western General Hospital Diogo Castro The National Institute for Medical The Ridgeway 43 | P á g i n a
Research Paulo Pereira Visual Neuroscience Laboratory University of Coimbra Daniel Finley Department of Cell Biology Jon Huibregtse Harvard Medical School The University of Texas at Austin ‐ ICMB 1 University Station A4800 Sylvie Urbe University of Liverpool Liverpool Michael Clague University of Liverpool Liverpool Ana Luísa Carvalho Depart. Zoology Ann Marie Craig Brain Research Centre University of Coimbra Department of Psychiatry, University of British Columbia Rachel Wong Department of Biological Structure Susana Correia Department of Pharmacology University of Washington University of Michigan Medical School Carlos Duarte Depart. Zoology University of Coimbra Armanda Santos Universidade de Coimbra Jonathan Ham Faculdade de Farmácia Molecular Haematology and Cancer Biology Unit Michael J. Courtney Department of Neurobiology Camelia Botnar Laboratories A.I. Virtanen Institute, University of Kuopio Luis Miguel Martins Cell Death Regulation Laboratory MRC Toxicology Unit Ana Cristina Rego Departamento de Bioquímica Universidade de Coimbra Cláudia Pereira Faculdade de Medicina / CNC Universidade de Coimbra Luís P. Almeida Faculdade de Farmácia / CNC Universidade de Coimbra Paula Agostinho Departamento de Zoologia Universidade de Coimbra Paula Moreira Instituto de Fisiologia Faculdade de Medicina Sandra Cardoso Faculdade de Medicina / CNC Universidade de Coimbra Department of Neuroscience, McKnight Brain Institute University of Florida Department of Neurology, Faculty of Medicine, S2 Laboratory University of Gottingen Hospitais da Universidade de Serviço de Neurologia Coimbra Hospitais da Universidade de Serviço de Neurologia Coimbra Hospitais da Universidade de Serviço de Neurologia Coimbra Departamento de Neurologia, UNIGEN, IBMC Hospital São Sebastião David Borchelt Sebastian Kugler Cristina Januário Isabel Santana Luís Negrão Paula Coutinho Sandra Macedo Ribeiro Tiago Outeiro Instituto Biol. Molecular e Celular University of Porto Harvard Medical School and Instituto de Medicina Molecular Boston and Lisboa Miguel Castelo‐Branco University of Coimbra Serge Picaud Visual Neuroscience Laboratory Center of Ophthalmology of Coimbra, IBILI Laboratoire de Physiopathologie Cellulaire et Moleculaire de la Retine Ulrich Schraermeyer University Hospital of Tubingen ‐ Clinic Section of Experimental Francisco Ambrósio University of Coimbra Universite Pierre et Marie Curie 44 | P á g i n a
of Ophthalmology Vitreoretinal Surgery Espen Hartveit Department of Biomedicine University of Bergen Celeste Lopes Faculty of Pharmacy and CNC Center for Neuroscience and Cell Biology University of Coimbra Sukalyan Chatterjee Anabela C. Silva University of Coimbra Maria C. Leite‐de‐Moraes Instituto de Biologia Celular e Molecular Faculdade de Farmácia René Descartes, Paris V, Hôpital CNRS, Faculté de Médecine Necker Helena Soares Steinman Lab, Bronk Building Rockefeller University Gil Castro Escola de Ciências da Saúde Universidade do Minho Iris Caramalho Ricardo Silvestre Instituto Gulbenkian de Ciência Lymphocyte Activation Group Instituto Ciências Biomédicas Abel Salazar e Instituto Biologia Molecular e Celular Universidade do Porto Instituto de Biologia Molecular e Celular e Faculdade de Farmácia Universidade do Porto Milton Costa Depart. Bioquímica ‐ CNC University of Coimbra Nuno Empadinhas University of Coimbra Life Sciences, Tel Aviv University Paula M. F. Silva Fred Rainey Depart. Bioquímica ‐ CNC Department of Molecular Microbiology and Biotechnology Department of Biochemistry, FCTUC and Instituto Ambiente e Vida Department of Zoology, FCTUC and CNBC Institute of Microbiology, FMUC and CNBC Bacterial Signalling Laboratory, IGC and ITQB Department of Biological Sciences, Louisiana State University Isabel Carreira Laboratório de Citogenética Faculdade de Medicina Ana Pombo Nuclear Organisation Group MRC Clinical Sciences Centre Eliora Ron Paula Morais António Veríssimo Teresa Gonçalves Karina Xavier University of Coimbra University of Coimbra University of Coimbra Universidade Nova de Lisboa Baton Rouge Joana Barbosa de Melo Laboratório de Citogenética Faculdade de Medicina Cátia Feliciano Department of Neurobiology Duke University Medical Center João Peça Department of Neurobiology Duke University Medical Center Guoping Feng Department of Neurobiology Duke University Medical Center Chinfei Chen Valerie Ego‐Stengel Children´s Hospital Unité de Neurosciences Intégratives et Computationnelles Harvard Medical School Institut de Neurobiologie Alfred Fessard, CNRS Anália do Carmo Faculty of Pharmacy and CNC University of Coimbra M.ª Celeste Lopes University of Coimbra Sukalyan Chatterjee Faculty of Pharmacy and CNC Center for Neuroscience and Cell Biology Vivek Mittal Cold Spring Harbor Laboratory New York Alea Mills Cold Spring Harbor Laboratory New York Fernando Schmitt Medicine Faculty of the Porto University IPATIMUP University of Coimbra 45 | P á g i n a
Iris Caramalho Instituto Gulbenkian de Ciência Oeiras João Barata Cancer Biology Unit Institute of Molecular Medicine João Nuno Moreira Faculty Pharmacy of Coimbra Coimbra University Anália do Carmo Faculty of Pharmacy and CNC University of Coimbra Teresa Cruz Faculty of Pharmacy and CNC Denis Soulet Neuronal Survival Unit ‐ Neurofortis University of Coimbra Department of Experimental Medical Science Roberta Martinelli Division of Cell Biology Institute of Ophthalmology Emília Duarte Faculdade Ciências e Tecnologia Universidade de Coimbra John Greenwood Division of Cellular Therapy Institute of Ophthalmology Angelo Chora Instituto Gulbenkian de Ciência Department Neuropharmacology at CNC and Faculty of Medicine Center of Ophthalmology of Coimbra, IBILI Oeiras Rodrigo Cunha Francisco Ambrósio Teresa Pais University of Coimbra University of Coimbra Oeiras Liliana Bernardino Instituto Gulbenkian de Ciência Pharmacology and Therapeutics Institute Center for Neuroscience and Cell Biology Center for Neuroscience and Cell Biology João Laranjinha Laboratory of Biochemistry University of Coimbra Leonor Almeida University of Coimbra Paulo Oliveira Laboratory of Biochemistry Mitochondrial Toxicology and Pharmacology Group, Center for Neurosciences and Cell Biology University of Coimbra Vitor M. C. Madeira Department of Biochemistry and CNC University of Coimbra Yvonne Will Early Safety Differentiation Group Pfizer Groton, CT Elaine Holmes Piero Portincasa Imperial College London Department of Internal Medicine and Public Medicine South Kensington Campus University of Bari Medical School Maria de Lourdes Bastos Faculty of Pharmacy University of Porto Rui Carvalho Depart. Biochemistry University of Coimbra Carlos Palmeira Depart. Zoology University of Coimbra Ana P. Silva Inês Araújo Faculty of Medicine Department of Zoology Department of Zoology 46 | P á g i n a
7. Institutional Consortium The programme provides a high quality advanced research‐oriented formation using International Research‐based Faculty members, some of whom have come over the years and are now in the process of establishing a quasi permanent consortium both for teaching and research. This has been leading to the development of the International Network of CNC. In the near future, the establishment of a formal network is envisisoned. 47 | P á g i n a
8. Other programmes that benefit from PDBEB
The students from the Masters in Cell Biology of the Faculty of Sciences of the University of Coimbra, as well as all the other students of CNC outside the programme attend on a regular basis the courses and seminars given by the programme. As shown underneath, each year the programme makes available high level research‐oriented courses for around 130 students. Non‐programme CNC PhD students 2005 – 97 students 2006 ‐ 112 students Masters in Cell Biology 2005/06 ‐ 24 students 2006/07 ‐ 20 students 48 | P á g i n a
9. Students, location, supervision and research focus
The programme has 71 students developing their work in Portugal, in different laboratories and abroad, scattered throughout the world in highly competitive laboratories, working in diverse areas of experimental biology and biomedicine. In previous editions the students have been encouraged to design with their national and foreign supervisors projects that involve collaborations between national and foreign laboratories, an approach that has been made mandatory since 2006. The aim is to promote development of high level thesis, promote networking and internationalization of national laboratories, while allowing the students to maintain ties with the national institutions that will permit them to work in our country after finishing their PhDs. The students, titles of thesis, supervisors and institutions are detailed for the first editions of the Programme in the subsequent pages. 49 | P á g i n a
Synthesis of heterosides in Archaea: Mannosylgycerate in Aeropyrum pernix and Glucosylglycerate in Methanohalophilus Mapeamento das áreas visuais do lobo temporal Joana Cardoso Costa [email protected] Mafalda Moreira Mendes [email protected] Margarida A. Vaz Caldeira [email protected] Raquel Aguiar de Oliveira [email protected] Ricardo Saraiva Correia [email protected] Regulation of ionotropic receptors expression by BDNF in neurons from hippocampus Proteomic analysis of mitotic chromosomes associated proteins in Drosophila melanogaster Role of the small GTPase cdc42 during myelination and re‐myelination of the Central Nervous System Identification of candidate genes and MHC ligands for allogeneic immunotherapeutic approaches in hematopoietic stem cell transplantation Mechanisms of cellular degeneration in diabetic rethinopaty: Involvement of inflamatory mediators and protein kinase C Development of New Effective Targeted Contrast Agents for Magnetic Resonance Imaging “ Constança Sofia Figueiredo Figueiredo.Constanca@mh‐
hannover.de Ermelindo Carreira Leal [email protected] Giovannia Araújo Pereira [email protected] Control of Morphogen Signal Transduction by Band 4.1 Family Proteins Catarina Brás S. Pereira [email protected] Miguel Castelo‐Branco Carlos B. Duarte Claudio Sunkel Catarina Oliveira Co‐orientador: João Relvas Johannes Peters Carlos Geraldes Milton Costa Rainer Blasczyk Carlos Duarte António F. Ambrósio Wellcome Trust Centre for Cell Biology – Institute of Cell and Molecular Biology / University of Edinburgh Centro de Neurociências e Biologia Celular William C. Earnshaw / Carlos Faro Francisco Ambrósio Caetana Carvalho Fernando Casares / Carlos Faro 50 | P á g i n a
Instituto Biologia Molecular e Celular – Universidade do Porto Faculdade Medicina – Universidade de Coimbra / Swiss Federal Institute of Technology Zurich Centro de Neurociências – Universidade de Coimbra IBILI – Centro de Oftalmologia Centro de Neurociências – Universidade de Coimbra Center of Ophthalmology of Coimbra, IBILI, Faculty of Medicine, University of Coimbra / Department of Ophthalmology, Institute of Medical Sciences , Foresterhill, Aberdeen AB25 2ZD, Scotland, United Kingdom Technical University Delft, Netherlands, Department of Organic Chemistry and Catalysis, Faculty of Applied Sciences Instituto Biologia Molecular e Celular – IBMC Sevilha – Andalusian Center for Development Biology / Pablo de Olavide University Department of Transfusion Medicine, Hannover Medical School, Carl – Neuberg ‐ Str. 1 – 30625 Hannover, Germany Institutions Instituto Biologia Molecular e Celular (IBMC) Supervisors Profª Drª Mónica Mendes Sousa PDBEB STUDENTS 2002/2003 Title of thesis Role of transthyretin in sensorimotor functions Genetic analysis of kinetochore function in vertebrate cells Mecanismos de neurodegeneração nos estados iniciais da retinopatia diabética: papel do glutamato Student Carolina Estima Fleming [email protected] Ana Mafalda B. Tadeu [email protected] Ana Raquel S. Santiago [email protected] Catarina Afonso Cruz [email protected] David Mendes da Silva [email protected] Filipe Josué Oliveira [email protected] Joana Brito Sequeira Mendes [email protected] Manuela Cristina Ferreira [email protected] [email protected] Sandra Domingues Santos [email protected] Sandrina Nóbrega Pereira [email protected] Susana Maia Lopes [email protected] Ana Luísa Vital Carvalho [email protected] Student Adriana Oliveira Santos [email protected] Alexandre Gaspar Maia [email protected] Ana Catarina Grandela [email protected] Neurobiologia da visão Cromática na saúde e na doença: dos fotoreceptores ao córtex visual Driving AMPA receptor sinto synapses: role of interacting proteins in the delivery of GluR4 containing AMPA receptors Cellular and molecular mechanisms controlling the migration of interneurons in the cerebral cortex The Biology of a Molecular Complex regulating Apoptosis and Proliferation Specification, regulation and dynamics of mammalian DNA replication origins Myelogenous Leukemia: The relative contribution of Bone Marrow Endothelial cells on the Myelopoiesis Assessment of intratumoral genetic heterogeneity in gliomas by combined interphase FISH, Cdna micro‐
array and immunophenotype: impact on the clinical and biological bahaviour of the disease Inductive signals and the control of neural cell fate in the developing vertebrate spinal cord Axons Guidance Cues and Development of the Accessory Olfactory System Regulation of Apoptosis and Differentiation in Human Embryonic Stem Cell Drª Ana Luisa Carvalho Prof. Carlos Duarte Dr. Óscar Marin Dr. Carlos Duarte Prof. Miguel Castelo‐Branco Prof. Eduardo Silva Prof. Sérgio Dias Prof. Carlos Duarte Dr. James Briscoe Dr. Jean – François Cloutier Drª Ana Luisa Carvalho Dr. Nicolas Tapon Dra. María Gómez Vicentefranqueira Drª Celeste Lopes Dr. Alberto Órfao e Vale Supervisors Prof. Sérgio Simões Prof. João Nuno Moreira Prof. Miguel Ramalho‐Santos Prof. João Ramalho‐Santos Prof. Martin Pera Prof. João Ramalho Santos PDBEB STUDENTS 2003/2004 Title of thesis Targeted antisense therapy: a novel approach for the treatment of human small cell lung cancer Genetic Regulation of stem cell pluripotency 51 | P á g i n a
Instituto de Neurociencias de Alicante Universidad Miguel Hernandez & CSIC Laboratory of Neuronal Migration and Specification Centro de Oftalmologia da Universidade de Coimbra Instituto Biomédico de Investigação da Luz e da Imagem Centro de Neurociências – Universidade de Coimbra Instituto de Microbiologia Bioquímica, CSIC/ Universidad de Salamanca Centro de Investigação de Patobiologia Molecular ( CIPM )‐ IPO Francisco Gentil de Lisboa University of California at San Francisco – UCSF / USA Program in Developmental and Stem Cell Biology Monash Institute of Reproduction and Development, Monash University and Center for Neuroscience and Cell Biology, University of Coimbra Centro de Neurociências – Universidade de Coimbra Centro de Investigación del Cancer e Servicio General de Citometria ‐ Univ. Salamanca Espanha Institute Medical Research , The Ridgeway, Mill Hill ‐ London ( Division of Developmental Neurobiology ) Centre for Neuronal Survival, Montreal Neurological Institute, Canada Centro de Neurociências – Universidade de Coimbra Câncer Research UK London Research Institute Institutions University of Zurich – Division of Medical Oncology Development mechanisms regulating the branching morphogenesis of axons and dendrites Susana Isabel Morgado Silva [email protected] Determination of the 3D structure of the translation factors that mediate a genetic code alteration in the pathogen Candida albicans Molecular Control of Pyramidal Cell Identity and Connectivity Foxp3 expression in T cell ontogeny – from embryonic development to vertebrate evolution Functional Proteomic Analysis of Synaptic Scaffolding Proteins Unravelling telomere chromatin structure in S. pombe Actividade biológica do óxido nítrico e derivados oxidados no tracto gastrointestinal e implicações no cancro do estômago Implications of HIF regulation, by ubiquitin – proteasome pathway in angiogenesis associated to diabetic retinopathy Molecular Motors for Endosomal Transport and Sorting of AMPARs Molecular Regulation of Microtubules in Drosophila Dr. Fan Wang Dr. Carlos Duarte Dr. Miguel Castelo‐Branco Dr. Nenad Sestan Drª Jocelyne Demengeot Drª Ana Luísa Carvalho Prof. Guoping Feng Prof. Carlos Duarte Drª Julie Cooper Dr. Paulo Pereira Prof. Manuel Santos Profª Sandra Ribeiro Dr. Paulo Pereira Fu Shang Supervisors Prof. Roger Patient Profª Ana Cristina Rego Dr. Michael Ehlers Dr. Carlos Duarte Dr. Hiro Ohkura Profª Ana Cristina Rego Prof. João Laranjinha Prof. Rui Barbosa PDBEB STUDENTS 2004/2005 Title of thesis Establishing the transcriptional regulatory networks controlling development of the myocardium João Henrique Lucas Duarte [email protected]
João Miguel Peça Silvestre [email protected] Luís Paulo Ferreira Valente [email protected] Rita Mafalda dos Santos Rocha [email protected] Sofia Maria Matos Fertuzinhos [email protected] Carla Alexandra Santos Bento [email protected] Student Ana Filipa da Costa Simões [email protected] Ana Isabel Ferreira Oliveira [email protected] Ana Margarida Meireles de Sousa [email protected] Bruno Miguel Fernandes Gago [email protected] 52 | P á g i n a
Faculdade de Ciências – Univ. Coimbra, Departamento de Bioquímica University of Yale, School of Medicine, Department of Neurobiology, United States of America Faculdade de Ciências – Universidade de Coimbra Cell Biology Dpt da Duke University Medical Center IBILI – Institute of Biomedical Research on Light and Image; Tufts University, Jean Mayer USDA Human Nutrition Research Center on Aging, Laboratory for Nutrition and Vision Research IGC – Instituto Gulbenkian de Ciência Oeiras, Portugal Duke University Medical Center Centro de Neurociências – Univ. Coimbra Câncer Research UK – London Research Institute Departamento de Biologia – Universidade de Aveiro Institutions Weatherall Institute of Molecular Medicine, Jonh Radcliffe Hospital, University of Oxford Centro de Neurociências Univ. de Coimbra Duke University, Durham, NC, USA Centro de Neurociências – Univ. de Coimbra Wellcome Trust Centre for Cell Biology, Institute for Cell Biology , Swann Building, Kings Building, University of Edinburgh Faculdade de Farmácia – Univ. Coimbra Karolinska Institute ‐ Suécia Gisela Machado Silva [email protected] Helena Sofia Domingues [email protected] Joana CravoLourenço [email protected] Lígia Carinha Gomes [email protected] Mariana Godinho Bexiga [email protected] Ricardo Miguel Marques [email protected] Ricardo José Soares [email protected] Eduardo Miguel Ferreira [email protected] Student Ana Clara Cristovão [email protected] Ana Isabel Teles [email protected] Carina Sousa Santos [email protected]
Catarina Sofia Pimentel [email protected] Dr.ª Alexandrina Mendes Dr.ª Ana Claudia Zenclussen Characterization of tolerance mechanisms at the fetal – maternal interface – Treg cells and novel tolerance‐
related molecules Live imaging analysis of host cytoskeleton dynamics during Plasmodium infection of human hepatocytes Investigations of mechanisms underlying growth cone advance and guidance in the model organism Drosophila melanogaster The role of stress in cortico‐basal ganglia loop processing and instrumental conditioning Dr.ª Ana Paula Silva Dr. Giovanni Marsicano Dr.ª Sandra Macedo Ribeiro Dr.ª Luca Scorrano Dr. Jean‐Marc Jacqué Dr. Luís Pereira de Almeida Dr. Miguel Castelo‐Branco Dr. Gero Miesenboeck Dr. Paulo Pereira Dr. Marco Sandri The endocannabinoid system and its role in regulating synaptic plasticity and adaptive behaviour Exploring the role of Fis1 in different modes of cell death: from cells to animal models Metabolic Changes induced by HIV‐1 infection of primary macrophages. The case of Neurotoxicity Temporal coding of odour representations in the antennal lobe of the fruit fly Molecular mechanisms regulating muscle atrophy 53 | P á g i n a
Faculdade de Medicina, Universidade de Coimbra Max‐Planck‐Institute of Neurobiology, Department of Neuroimmunology, Mastinsried, Munich, Germany Instituto Farmacologia e Terapêutica Experimental, Faculdade Medicina, Universidade Coimbra Institute François Magendie, Bordeaux, France Centro Neurociências e Biologia Celular – Univ. Coimbra Dulbecco ‐ Telethon Institute, Venetian Institute of Molecular Medicine, Padova ‐ Italy Centre for Research in Infectious Diseases, University College Dublin, Irlanda Instituto BiomédicoInvest. Luz e Imagem, Univ. Coimbra Yale Medical School, Cell Biology Department IBILI, Univ. of Coimbra Dulbecco‐Telethon Institute, Venetian Institute of Molecular Medicine, Italy Dr. João Malva Dr. Hartmut Wekerle Investigating signalling pathways involved in the regulation of cell growth in mammalian cells – the role of insulin, IGF‐1 and serum Role of microglia in the modulation of T cell immune responses in the pathogenesis of EAE Universidade do Minho, Braga/ National Institute on Alcohol Abuse and Alcoholism of the National Institutes of Health, USA/IBILI, Univ. Coimbra Centro Neurociências e Biologia Celular – Univ. Coimbra University College London, Câncer Research UK Institutions Faculdade Ciências e Tecnologia, Dep. Zoologia, Univ. Coimbra Faculdade Ciências Saúde, Univ. Beira Interior, Covilhã Faculdade Farmácia, Universidade de Coimbra Institute of Medical Immunology, Biomedical Research Institute, Charité, Berlim, Germany Instituto Medicina Molecular, IPO ‐ Lisboa Centro Neurociências e Biologia Celular – Univ. Coimbra Centro Neurociências e Biologia Celular – Univ. Coimbra Faculty of Life Sciences, University of Manchester, UK Dr. Nuno Sousa Dr. Rui Costa Dr. Miguel Castelo‐Branco Dr. Carlos Duarte Dr.ª Alison Lloyd Dr.ª Maria Mota Dr.ª Ana Luísa Carvalho Dr.ª Ana Luísa Carvalho Dr.ª Andreas Prokop Supervisors Prof.ª Emília Duarte Prof.ª Graça Baltazar PDBEB STUDENTS 2005/2006 Title of thesis Role of astrocytes in microglia modulation: involvement in the neuroprotective‐neurotoxic microglia switch Vera Sofia Ribeiro ( [email protected] ) Sara Maurício Sousa ( [email protected] ) Sofia Soares Grade ( [email protected] ) Pedro Manuel Branco ( [email protected] ) Joana Margarida Gaspar ( [email protected] ) Marina Lurdes Brito ( [email protected] ) “T Cell Development: determining factors for the differentiation & selection of γδ and αβ cells” “Impact of diabetes on exocytosis and on neuromodulation in hippocampus” “Effects of cocaine and nicotine on the mesolimbic dopaminergic system study by in vivo cellular imaging“ “Systems‐oriented analysis of the regulation of protein‐reactive metabolic intermediates in human erythrocytes“ “The origin and dynamics of blastemal cells during zebrafish caudal fin regeneration” “Modulation of subventricular zone‐derived cells migration by mediators of neuroinflammation” “Role of thymic versus extra‐thymic derived NK cells in the priming of T‐cells and their differentiation into effector cells “ “Neural Mechanisms of Innate Fear” Gil Pereira Costa ( [email protected] ) Joana Filipa Neves ( [email protected] ) Ana Raquel Soares ( [email protected] ) Daniel Farinha Nunes ( [email protected] ) “Apoptosis Signaling as a Therapeutic Target in Melanoma“ “Interplay between angiogenesis and neurogenesis in the intact and injured brain: new perspectives for the use of adult stem cells in brain repair” “Assessing microRNA functions and targets in Zebrafish” “Contribution of lateral inhibition to odor discrimination: from molecules to behavior” Ana Caldeira Burgeiro ( [email protected] ) Alexandra Isabel Rosa ( [email protected] ) Dr. Euclides Pires Dr. James Di Santo Dr.ª Margarida C. Neves Dr. António Jacinto Dr. Carlos Faro João Malva Dr. Pierre Vincent Dr. Nuno Sousa Dr.ª Emília Duarte Dr. Armindo Salvador John Jones Dr.ª Celeste Lopes Dr. Manuel Santos Dr. Carlos Duarte Dr. Zachary F. Mainen Dr. Thomas Kuner Dr. Carlos Duarte Dr. Zachary F. Mainen Dr. Euclides Pires Dr. Bruno Silva Santos Dr. Daniel Pennington Dr. Francisco Ambrósio Dr. Paulo Oliveira Faustino Mollinedo João Malva ORIENTADOR INSTITUIÇÕES: Portuguesa / Estrangeira 54 | P á g i n a
CNC/ FCTUC ‐ Universidade de Coimbra Cytokines and Lymphoid Development Lab/ Institut Pasteur – Paris, France ICVS – Life and Health Sciences Research Institute, University of Minho, Portugal Instituto Medicina Molecular, Faculdade Medicina, Universidade de Lisboa Departamento de Bioquímica, FCTUC / CNC ‐ Universidade Coimbra Centro Neurociências Coimbra, Departamento de Zoologia, Universidade de Coimbra Faculdade de Farmácia, Universidade de Coimbra Departamento de Biologia, Universidade de Aveiro Centro de Neurociências – Universidade de Coimbra Cold Spring Harbor, New York Institut fur Anatomie und Zellbiologie, Universitat Heidelberg, Alemanha Centro de Neurociências – Universidade de Coimbra Cold Spring Harbor, New York CNC/ FCTUC ‐ Universidade de Coimbra Instituto Medicina Molecular, Faculdade Medicina – Universidade de Lisboa Institut of cell and Molecular Science, Queen Mary College, London Centro de Oftalmologia da Universidade de Coimbra Instituto Biomédico de Investigação da Luz e da Imagem Neurobiologie des Processus Adaptatifs, UMR7 102 CNRS Université Paris 6, France ICVS ‐ ICVS – Life and Health Sciences Research Institute, University of Minho, Portugal Centro Neurociências Coimbra, Dept. Zoologia, Universidade Coimbra CNC/ Departamento de Química, Universidade de Coimbra CNC – Universidade de Coimbra Centro Neurociências Coimbra, Departamento de Zoologia, Universidade de Coimbra Centro de Investigación del Câncer, Universidad Salamanca, CSIC, Espanha Centro Neurociências Coimbra, Dept. Zoologia, Universidade Coimbra CNC – PROGRAMA DOUTORAL 2006/2007 TÍTULO TRABALHO NOME Susana Ribeiro Louros ([email protected]) Ana Sofia Azevedo ([email protected]) Filipe Sousa Leal ([email protected]) Gil Nunes Cunha ([email protected]) Joana Catarina Marinho ([email protected]) João Noutel Santos ([email protected]) Lígia Catarina Silva ([email protected]) Manuel Afonso Barroso ([email protected]) Nélio Mota Gonçalves ([email protected]) Sara Rute Figueiredo ([email protected]) Sueli Cristina Marques ([email protected]) “The Role of Transmembrane AMPA Receptor Regulatory Proteins (TARPs) in Synapse Remodeling” “Targeting Lipossomal Therapy for the Treatment of Breast Câncer” “The Immune Response to Mycobacteria of Distinct Virulence” “Gene Transfer Approach for the Study of the Adenosine A2a Receptors Role in Machado Joseph Disease” “Innovative Paramagnetic Liposomes for the Visualization of Drug Delivery/Release Processes by Magnetic Resonance Imaging” “Epigenetics in Age‐Related Neurodegeneration” “Molecular and Cellular Mechanisms Controlling Collective Cell Migration and Invasive Behaviour During Development” “Regeneration in Zebrafish Caudal Fin: Looking for New Players” “Regulation of the Formation of Microtubule Organizing Structures” “Brain‐Reading the Neural Bases of Visual Impairment and Rehabilitation in Amblyopia” “Molecular and Cellular Analysis of the Function of the Viriato Gene in Drosophila Eye Development” “Synapse Remodeling in a Mouse Model for ASD” Ana Sofia M. Cabral ([email protected]) 55 | P á g i n a
Faculdade Ciências e Tecnologia, Departamento de Bioquímica, Universidade de Coimbra Centro Neurociências e Biologia Celular – Univ. Coimbra/ Faculdade Farmácia UC Faculdade de Ciências, Universidade de Turim Centro de Neurociências e Biologia Celular – Univ. Coimbra/ Faculdade Medicina da UC Centro Neurociências e Biologia Celular – Univ. Coimbra/ Departamento Zoologia FCTUC Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa Karolinska Institute Centro Neurociências e Biologia Celular – Univ. Coimbra/ Departamento Zoologia FCTUC Harvard Medical School, Boston Dr. Carlos Geraldes Dr. João Nuno Moreira Dr. Silvio Aime Dr.ª Cláudia Pereira Dr. Carlos Duarte Dr. Tiago Outeiro Dr. Joseph Bertrand Dr.ª Ana Luísa Carvalho Dr.ª Chinfei Chen Dr.ª Ana Luísa Carvalho Dr.ª Chinfei Chen Dr. João Nuno Moreira Dr. Sérgio Simões Dr. Rui Appelberg Dr. Milton Costa Dr. Luís Almeida Dr. Rodrigo Cunha Dr. Paulo Pereira Dr.ª Paula Veríssimo Centro Neurociências e Biologia Celular – Univ. Coimbra/ Departamento Zoologia, FCTUC Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa/ IGC Instituto de Biologia Molecular de Barcelona, Espanha Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa Centro Neurociências e Biologia Celular – Univ. Coimbra/ Departamento Zoologia da FCTUC Instituto Gulbenkian de Ciência Centro Neurociências e Biologia Celular – Univ. Coimbra/ Departamento Bioquímica FCTUC EMBL Heidelberg, Germany IBILI – Centro de Oftalmologia Faculdade de Medicina, Universidade de Coimbra Instituto Biologia Molecular e Celular (IBMC), Universidade do Porto Centro Neurociências e Biologia Celular – Universidade Coimbra/ Departamento Bioquímica FCTUC Centro Neurociências e Biologia Celular – Univ. Coimbra/ Departamento Zoologia FCTUC Harvard Medical School, Boston Faculdade de Farmácia, Universidade de Coimbra Centro de Neurociências e Biologia Celular, Universidade de Coimbra Instituto Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto Centro Neurociências e Biologia Celular – Univ. Coimbra/ Departamento Bioquímica FCTUC Centro Neurociências e Biologia Celular – Universidade Coimbra/Faculdade Farmácia UC Centro Neurociências e Biologia Celular – Universidade Coimbra/ Faculdade Medicina UC INSTITUIÇÕES: Portuguesa / Estrangeira Dr. Carlos Duarte Dr. António Jacinto Dr. Enrique Blanco Dr.ª Leonor Saúde Dr. Carlos Duarte Dr.ª Mónica Dias Dr.ª Paula Veríssimo Dr. Eric Karsenti Dr. Miguel Castelo‐Branco ORIENTADOR CNC – PROGRAMA DOUTORAL 2007/2008 TÍTULO TRABALHO NOME Students
Ana Lúcia Ramos* Ana Sofia Rodrigues* Beatriz Lacerda Sousa* Carolina Paiva Coelho* Carlos Guedes de Melo* Diana Margarida Carvalho* Joana Santos Barbosa* Marco Filipe Craveiro* Pedro Réu Carvalho* Renata Mota Gomes* Samira Cardoso Ferreira* Sílvia Viana Silva* 56 | P á g i n a
PDBEB STUDENTS 2008/2009 Students from this edition started the program in September of 2008 and therefore have not yet defined projects and supervisors 10. Annual Meetings Every year an Annual meeting is organized to give the PDBEB students the opportunity for interaction, to present their research work and for assessment of progression. In 2005, PDBEB students attended the joint meeting of the National Graduate Programme on Biosciences, which was held in Tomar, from 18 to 21 December and organized by CNC, on this edition. In 2006, PDBEB students attended the Annual Meeting of the PhD Programme of Experimental Biology and Biomedicine, 16 to 17 December 2006, Biocant, Cantanhede. In 2007, PDBEB students attended the Annual Meeting of the PhD Programme of Experimental Biology and Biomedicine, 20 to 21 December 2007, Fundação Bissaya Barreto, Bencanta, Coimbra. In 2008, PDBEB students attended the Annual Meeting of the PhD Programme of Experimental Biology and Biomedicine, 16 to 17 December 2008, Biocant, Cantanhede. See Annex 1, 2, 3 and 4 for detailed program of the meetings. 57 | P á g i n a
11. Accomplishment and progress of the students The 43 publications in high level peer‐reviewed journals produced by PDBEB students are already demonstrating the success of the programme. These publications are mostly the result of the work of students from the two first editions of the programme. As expected from students that start their research work with a delay of 6 to 8 months, as compared to students who don’t follow a PhD programme, the 3 years and some months that are used for development of the thesis is generally unsuficient, which reflects in the low number of thesis that have been finished until now. Nevertheless, 9 students are expected to finish their thesis with the year. Furthermore, the initial investment in the courses Programme is expected to be recuperated later on by students that are better prepared to lead their own research projects in cutting edge science. PDBEB 02/03
Thesis
Constança Figueiredo* 21 de Dezembro 2006 Regulating HLA class I expression for cellular therapeutics; University of Coimbra. Margarida Caldeira* 4 de Maio 2007 Regulation of inonotropic receptors of glutamate by BDNF in neurons from hippocampus; University of Coimbra.
Raquel de Oliveira* 4 de Maio 2007 Condensins and mitotic chromosome structure: functional and dynamic analysis in Drosophila melanogaster. Joana Cardoso Costa* 21 de Janeiro 2008 Synthesis of heterosides in Archaea: Mannosylgycerate in Aeropyrum pernix and Glucosylglycerate in Methanohalophilus Giovannia Araújo Pereira * 24 de Janeiro 2008 Development of New Effective Targeted Contrast Agents for Magnetic Resonance Imaging Carolina Estima Fleming * 14 de Março 2008 Role of transthyretin in sensorimotor functions Ana Raquel Santiago* 30 de Junho 2008 Mecanismos de neurodegeneração nos estados iniciais da retinopatia diabética: papel do glutamato. Ricardo Saraiva Correia * 10 de Outubro 2008 Role of the small GTPase cdc42 during myelination and re‐myelination of the Central Nervous System Catarina Brás Pereira * 27 de Outubro 2008 Control of Morphogen Signal Transduction by Band 4.1 Family Proteins Ermelindo Carreira Leal * 9 de Dezembro 2008 Mecanismos de degeneração celular na retinopatia diabética: o envolvimento de mediadores inflamatórios e da proteína cinase C 58 | P á g i n a
PDBEB 02/03
Publications
Santiago AR, Cristóvão AJ, Santos PF, Kamphuis W, Ambrósio AF. Diabetes induces changes on the levels of ionotropic glutamate receptors in the rat retina. (in preparation). Santiago AR, Garrido MJ, Cristóvão AJ, Duarte JMN, Carvalho RA, Ambrósio AF. Diabetes inhibits glycolysis in the rat retina. (in preparation). Santiago AR, Carvalho CM, Carvalho AP, Ambrósio AF (2008). Differential Contribution of L‐, N‐, and P/Q‐type Calcium Channels to [Ca2+]i Changes Evoked by Kainate in Hippocampal Neurons. Accepted for publication in Neurochem Res. Santiago AR, Hughes JM, Kamphuis W, Schlingemann RO, Ambrósio AF (2008).Diabetes changes ionotropic glutamate receptor subunit expression level in the human retina. Brain Res, doi:10.1016/j.brainres.2007.12.030. Santiago AR, Santos PF, Cristóvão AJ, Carvalho CM, Ambrósio AF (2007).High glucose induces caspase‐independent cell death in retinal neural cells. Neurobiol Dis; 25(3): 464‐472. Alvaro AR, Rosmaninho‐Salgado J, Santiago AR, Martins J, Aveleira C, Santos PF, Pereira T, Gouveia D, Carvalho AL, Grouzmann E, Ambrósio AF, Cavadas C (2007). NPY in rat retina is present in neurons, in endothelial cells and also in microglial and Muller cells. Neurochem Int; 50(5): 757‐763. Santiago AR, Rosa SC, Santos PF, Cristóvão AJ, Barber AJ, Ambrósio AF (2006). High glucose decreases Ca2+ permeability of AMPA receptors and alters calcium homeostasis in retinal neural cells. Invest Ophthalmol Vis Sci; 47(9): 4130‐4137. Santiago AR, Pereira TS, Garrido MJ, Cristóvão AJ, Santos PF, Ambrósio AF (2006). High glucose and diabetes increase the release of [3H]‐D‐aspartate in retinal cell cultures and in rat retinas. Neurochem Int; 48(6‐7): 453‐458. EC Leal, Santiago AR, Ambrósio AF (2005). The old and new drug targets in Diabetic Retinopathy: from biochemical changes to inflammation and neurodegeneration. Curr Drug Targets CNS Neurol Disord; 4(4):421‐434 Bras‐Pereira C, Casares F. (2008) An antennal‐specific role of bowl in repressing wingless to ensure correct proximo‐distal axis specification. Mech Dev. 125(9‐10): 809‐21. Tena JJ, Neto A, de la Calle‐Mustienes E, Bras‐Pereira C, Casares F*,Gomez‐Skarmeta JL*. (2007) Odd‐skipped genes encode repressors that control kidney development. Dev Biol. 301(2):518‐31. Bras‐Pereira C, Bessa J, Casares F. (2006) Odd‐skipped genes specify the signaling center that triggers retinogenesis in Drosophila. Development 133(21): 4145‐9. Fleming CE, Nunes AF, Sousa MM. Transthyretin: more than meets the eye. Submitted. Fleming CE, Saraiva MJ, Sousa MM. Transthyretin internalization by neurons is megalin‐mediated and necessary for its neuritogenic activity. Submitted. Liz MA, Fleming CE, Nunes AF, Choe Y, Craik CS, Powers JC, Bogyo M, Sousa MM. Transthyretin has natural substrates in the nervous system. Submitted. 59 | P á g i n a
Fleming CE, Saraiva MJ, Sousa MM. Transthyretin enhances nerve regeneration. J Neurochem 103:831‐9. Figueiredo C, Wittmann M, Dressel R, Seltsam A, Blasczyk R, Eiz‐Vesper B. Heat Shock Protein 70 (HSP70) induces cytotoxicity of T helper cells. Blood, in press Figueiredo C, Seltsam A, Blasczyk R. Permanent silencing of NKG2A expression for cell‐based therapeutics. J Mol Med, in press Seltsam A, Grüger D, Just B, Figueiredo C, Gupta CD, Deluca DS, Blasczyk R. Aberrant intracellular trafficking of a variant B glycosyltransferase. Transfusion. 2008 Horn PA, Figueiredo C, Kiem HP. Gene therapy in the transplantation of allogeneic organs and stem cells. Curr Gene Ther 2007; 7:458‐68. Figueiredo C, Horn PA, Blasczyk R, Seltsam A. Regulating MHC expression for cellular therapeutics. Transfusion 2007; 47: 18‐27 Figueiredo C, Seltsam A, Blasczyk R. Class‐, gene‐ and group‐specific HLA silencing by lentiviral shRNA delivery. J Mol Med 2006; 84: 425‐37 Bade‐Doeding C, Eiz‐Vesper B, Figueiredo C, Seltsam A, Elsner HA, Blasczyk R. Peptide‐binding Motif of HLA‐A*6603. Immunogenetics 2005; 56: 769‐72 Leal EC, Aveleira CA, Castilho AF, Serra AM, Baptista FI, Hosoya K, Forrester JV, Ambrósio AF. High glucose and oxidative/nitrosative stress conditions induce apoptosis in retinal endothelial cells by a caspase‐independent pathway. (In revision, Exp Eye Res) Leal EC, Aveleira CA, Castilho AF, Baptista FI, Ambrósio AF. Müller cells do not influence leukocyte adhesion to retinal endothelial cells. Ocul Immunol Inflamm. 2008 Jul‐Aug;16 (4):173‐9. Leal EC, Manivannan A, Hosoya K, Terasaki T, Cunha‐Vaz J, Ambrósio AF, Forrester JV. Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood‐retinal barrier breakdown in diabetic retinopathy. Invest Ophthalmol Vis Sci. 2007 Nov;48(11):5257‐65. Leal EC, Santiago AR, Ambrósio AF. Old and new drug targets in diabetic retinopathy: from biochemical changes to inflammation and neurodegeneration. Curr Drug Targets CNS Neurol Disord. 2005 Aug; 4(4):421‐34. Review. Zuzana Kotková, Giovannia A. Pereira, Kristina Djanashvili, Jan Kotek, Jakub Rudovský, Petr Hermann, Luce Vander Elst, Robert N. Muller, Carlos F. G. C. Geraldes, Ivan Luke , Joop A. Peters. “Lanthanide(III) Complexes of Phosphorus Acid Analogues of H4DOTA as Model Compounds for the Evaluation of the Second‐Sphere Hydration” , Eur. J. Inorg. Chem., 2008, DOI: 10.1002/ejic.200800859. G. A. Pereira, C. F. G. C. Geraldes. “Design and Optimization of Gadolinium Based Contrast Agents for Magnetic Resonance Imaging”. Ann. Magn. Reson., 2008, 6 (1,2), 1‐33. Pereira, G.A.; Norek, M.; Peters, J.A; Ananias D.; Rocha, J.; Geraldes, C.F.G.C. “NMR Transversal Relaxivity of Aqueous Suspensions of Particles of Ln3+‐Based Zeolite Type Materials”, Dalton Transactions, 2008, 2241‐2247 Pereira, G.A. and Geraldes, C.F.G.C. “Design and Optimization of Gadolinium Based Agents for Magnetic Resonance Imaging”, Ann. Magn. Reson., 2007, 6 (1‐2), 1‐33. 60 | P á g i n a
Torres, S.; Martins, J.A.; André, J.P.; Pereira, G.A.; Kiraly, R.; Brücher, E.; Helm, L.; Tóth, E.; Geraldes, C.F.G.C. “H5EPTPACH2OH: Synthesis, relaxometric characterization and 1H NMR studies of the solution dynamics of its Ln(III) complexes”, Eur.J.Inorg.Chem. 2007, 5489‐5499. Norek, M.; Pereira, G.A.; Geraldes, C.F.G.C.; Denkova, A.; Zhou, W.; Peters, J.A. “NMR Transversal relaxivity of suspensions of lanthanide oxide nanoparticles”, J. Phys. Chem. C. 2007, 111, 10240‐10246. Pereira, G.A.; Ananias, D.; Rocha, J.; Amaral, V.S.; Muller, R.N.; Elst, L.V.; Tóth, É; Peters, J.A.; Geraldes, C.F.G.C. “NMR relaxivity of Ln3+‐based zeolite‐type materials”, J. Mater. Chem., 2005, 15, 3832‐3837. J. Costa, N. Empadinhas, and M. S. da Costa. 2007. Glucosylglycerate biosynthesis in the deepest lineage of Bacteria. Characterization of the thermophilic GpgS and GpgP from Persephonella marina. J. Bacteriol. 189:1648‐1654. J. Costa, N. Empadinhas, L. Gonçalves, P. Lamosa, H. Santos, and M. S. da Costa. Characterization of the biosynthetic pathway of glucosylglycerate in the archaeon Methanococcoides burtonii. J. Bacteriol. 2006. 183:1022‐1030. J. Costa, I. Tiago, M. S. da Costa, and António Veríssimo. The presence and persistence of Legionella spp. in ground waters. Appl. Environ. Microbiol. 71:663‐671. N. Empadinhas, L. Albuquerque, J. Costa, S. H. Zinder, M. Santos, H. Santos, and M. S. da Costa. 2004. A gene from the mesophilic bacterium Dehalococcoides ethenogenes encodes a novel mannosylglycerate synthase. J. Bacteriol. 186:4075‐4084. P. Santos, I. Pinhal, F. Rainey, N. Empadinhas, J. Costa, B. Fields, R. Benson, A. Veríssimo, and M. S. da Costa. 2003. Gamma‐Proteobacteria Aquicella lusitana gen. nov., sp. nov., and Aquicella siphonis sp. nov. infect protozoa and require activated charcoal for growth in laboratory media. Appl. Environ. Microbiol. 69:6533‐6540. Miguel Castelo‐Branco, Mafalda Mendes, Fátima Silva, João Massano, Gustavo Januário, Cristina Januário, António Freire. (2008) “Motion integration deficits are independent of magnocellular impairment in Parkinsonʹs disease” (submitted) Castelo‐Branco, M., Mendes M., Sebastião, A.R., Reis, A., Soares, M., Saraiva J., Bernardes, R., Flores, R., Pérez‐Jurado, L., Silva, E. (2007) “A novel visual phenotype in Williams syndrome challenges magnocellular theories explaining neurodevelopmental visual cortical disorders” Journal of Clinical Investigation 117(12):3720‐9. (Mafalda Mendes e Miguel Castelo‐branco partilham a 1ª autoria) Castelo‐Branco M, Mendes M, Silva MF, Januário C, Machado E, Pinto A, Figueiredo P, Freire A. (2006) “Specific retinotopically based magnocellular impairment in a patient with medial visual dorsal stream damage” Neuropsychologia 44 (2):238‐53. Mendes M., Silva F., Simões L., Jorge M., Saraiva J., and Castelo‐Branco M. (2005) ʺVisual magnocellular and structure from motion perceptual deficits in a neurodevelopmental model of dorsal stream function” Cognitive Brain Research 25(3):788‐98. Sandra D. Santos, Ana L. Carvalho, Margarida V. Caldeira and Carlos B. Duarte (2008) Regulation of AMPA receptors and synaptic plasticity. Neuroscience. In press Ana L. Carvalho, Margarida V. Caldeira, Sandra D. Santos and Carlos B. Duarte (2008) Role of BDNF at glutamatergic synapses. Br J Pharmacol, 153:Suppl 1:S:310‐S324. Margarida V. Caldeira, Carlos V. Melo, Daniela B. Pereira, Ana L. Carvalho and Carlos B. Duarte. BDNF regulates the expression and modulates the activity of NMDA receptor subunits in hippocampal neurons. Molecular Cell Neuroscience, 2007, 35: 208‐219 61 | P á g i n a
Margarida V. Caldeira, Carlos V. Melo, Daniela B. Pereira, Ricardo Carvalho, Susana Correia, Donald S. Backos, Ana L. Carvalho, José A. Esteban and Carlos B. Duarte. BDNF regulates the expression and the synaptic delivery of AMPA receptor subunits in hippocampal neurons. Journal of Biological Chemistry, 2007, 282:12619‐12628 Ana L. Carvalho, Margarida V. Caldeira, André R. Gomes, Arsélio P. Carvalho and Carlos B. Duarte. Regulation of AMPA receptors by metabotropic receptors and receptor tyrosine kinases: mechanisms and physiological roles. Handbook of Neurochemistry and Molecular Neurobiology (3 rd edition; Ed. A. Lajtha; volume 2 edited by M. Hamon and E.S.Vizi). In press Oliveira, R.A., Coelho, P.A. and Sunkel, C.E. (2005). The condensin I subunit Barren/CAP‐H is essential for the structural integrity of centromeric heterochromatin during mitosis. Mol Cell Biol, 25, 8971‐8984. Oliveira, R.A, Heidmann, S., and Sunkel, C.E. (2007). Condensin I binds chromatin early in prophase and displays a highly dynamic association with Drosophila mitotic chromosomes. Chromosoma (published online on 27th February 2007). PDBEB 03/04
Publications
Santos, A., Ribeiro, A.B., de Lima, M.C., Simoes, S. and Moreira, J.N., Simultaneous evaluation of viability and Bcl‐2 in small‐
cell lung cancer. Cytometry A, 2008. Moreira, J.N., Santos, A., Moura, V., Pedroso de Lima, M.C. and Simoes, S., Non‐viral lipid‐based nanoparticles for targeted cancer systemic gene silencing. J Nanosci Nanotechnol, 2008. 8(5): p. 2187‐204. Moreira, J.N., Santos, A. and Simoes, S., Bcl‐2‐targeted antisense therapy (Oblimersen sodium): towards clinical reality. Rev Recent Clin Trials, 2006. 1(3): p. 217‐35. Gaspar‐Maia, A., Heidersbach, A., McManus, M., Meshorer, E., Ramalho‐Santos, M. Chd1 regulates open chromatin and pluripotency of ES cells. Submitted Wong, C.C., Gaspar‐Maia, A., Ramalho‐Santos, M., Reijo‐Pera, R.A. 2008. High‐efficiency stem cell fusion‐mediated assay reveals Sall4 as an enhancer of reprogramming. PLoS One 3(4): e1955 Grskovic, M., Chaivorapol, C., Gaspar‐Maia, A., Li, H., Ramalho‐Santos, M. 2007. Systematic identification of cis regulatory sequences active in mouse and human embryonic stem cells. PLoS Genetics, 3(8): e145 Teles‐Grilo, M.L., Duarte, S.M., Tato‐Costa, J., Gaspar‐Maia, A., Oliveira, C., Rocha, A.A., Marques, A., Cordeiro‐da‐Silva, A. , Azevedo, C.. 2007 Molecular karyotype analysis of Perkinsus atlanticus (Phylum Perkinsozoa) by pulsed field gel electrophoresis. Eur J Protistol. Nov;43(4):315‐8. Teles‐Grilo, M.L., Tato‐Costa, J., Duarte, S.M., Gaspar‐Maia, A., Casal, G., Azevedo, C. 2007. Is there a plastid in Perkinsus atlanticus (Phylum Perkinsozoa)? Eur J Protistol. Jun;43(2):163‐7. Heidersbach, A., Gaspar‐Maia, A., McManus, M., Ramalho‐Santos, M. 2006. RNA interference in embryonic stem cells and the prospects for future therapies. Gene Therapy 13:478‐86 Grandela C and Wolvetang E (2007) hESC Adaptation, Selection and Stability. Stem Cell Reviews. 2007. 3, 183‐91. 62 | P á g i n a
Grandela C, Pera MF and Wolvetang EJ. p53 is required for etoposide‐induced apoptosis of human embryonic stem cells. Stem Cell Research 2007. In Press Dobbelaere J, Josué F, Suijkerbuijk S, Baum B, Tapon N and Raff J. (2008) A Genome‐Wide RNAi Screen to Dissect Centriole Duplication and Centrosome Maturation in Drosophila PLoS Biol 6(9): e224 doi:10.1371/journal.pbio.0060224 http://dx.doi.org/10.1371/journal.pbio.0060224 Colombani J, Polesello C, Josué F, Tapon N. Dmp53 activates the Hippo pathway to promote cell death in response to DNA damage.Curr Biol. 2006 Jul 25;16(14):1453‐8. http://dx.doi.org/10.1016/j.cub.2006.05.059 Transcription initiation activity sets replication origin efficiency in mammalian cellsʺ Sequeira‐Mendes, J; Diaz‐Uriarte, R; Apedaile, A; Huntley, R; Brockdorff, N and Gomez, M; PLoS Biology (submitted) Santos SD, Carvalho AL, Caldeira MV and Duarte CB. Regulation of AMPA Receptors and synaptic plasticity. Neuroscience 2008 Feb 29 [Epub ahead of print]. Carvalho AL, Caldeira MV, Santos SD and Duarte CB. Role of the brain‐derived neurotrophic factor at glutamatergic synapses Br J Pharmacol. 2008 Mar;153 Suppl 1:S310‐24. Moreno AJ, Oliveira PJ, Nova CD, Alvaro AR, Moreira RA, Santos SM, Macedo, T. Unaltered hepatic oxidative phosphorylation and mitochondrial permeability transition in wistar rats treated with nimesulide: Relevance for nimesulide toxicity characterization. J Biochem Mol Toxicol. 2007;21(2):53‐61. Malva, J.O., Santos, S. & Macedo, T.R. (2004) Neuroprotective properties of Valeriana officinalis extracts. Neurotoxicity Research 6(2):131‐40 Pereira, C.F., Santos, S.D., Ribeiro, C.F., Ali, S.F., and Macedo, T.R. (2004) A single exposure to morphine induces long‐
lasting hyporreactivity of rat caudate putamen dopaminergic nerve terminals. Ann. N.Y. Acad. Sci 1025:414‐23 Nobrega‐Pereira S and Marín O. Transcriptional control of neuronal migration and guidance decisions in the developing telencephalon. Submitted to Cerebral Cortex (Review). Nobrega‐Pereira S, Kessaris N, Du T, Kimura S, Anderson S, Marín O. Postmitotic Nkx2‐1 controls the migration of telencephalic interneurons by direct repression of guidance receptors. Neuron. 2008 Sep 11:59(5):733‐45. Lavreysen H, Wouters R, Bischoff F, Nobrega Pereira S, Langlois X, Blokland S, Somers M, Dillen L and Lesage ASJ. JNJ16259685, a highly potent, selective and systemically active mGlu1 receptor antagonist. Neuropharmacology. 2004 Dec: 47(7): 961‐72. Lavreysen H, Nobrega Pereira S, Leysen JE, Langlois X, Lesage ASJ. Metabotropic glutamate 1 receptor distribution and occupancy in the rat brain: a quantitative autoradiographic study using [3H]R214127. Neuropharmacology. 2004 Apr: 46(5): 609‐19. Retinal Function in Best Macular Dystrophy: Relationship Between Electrophysiological, Psychophysical and Structural Measures of Damage. Invest Ophthalmol Vis Sci. 2008 Sep 4. [Epub ahead of print] PMID: 18775865 [PubMed ‐ as supplied by publisher]2: Related Articles, Links Maia‐Lopes S, Castelo‐Branco M, Silva E, Aguirre J, Riveiro‐Alvarez R, Trujillo‐Tiebas MJ, Ayuso C. 63 | P á g i n a
Gene symbol: BEST1. Disease: Best macular dystrophy. Hum Genet. 2008 Feb;123(1):112. No abstract available. PMID: 18386373 [PubMed ‐ indexed for MEDLINE]3: Related Articles, Links Maia‐Lopes S, Castelo‐Branco M, Silva E, Aguirre J, Riveiro‐Alvarez R, Trujillo‐Tiebas MJ, Ayuso C. Gene symbol: ABCA4. Disease: Macular dystrophy. Hum Genet. 2008 Feb;123(1):112. No abstract available. PMID: 18386369 [PubMed ‐ indexed for MEDLINE]4: Related Articles, Links Maia‐Lopes S, Castelo‐Branco M, Silva E, Aguirre J, Riveiro‐Alvarez R, Trujillo‐Tiebas MJ, Ayuso C. Gene symbol: ABCA4. Disease: Macular dystrophy. Hum Genet. 2008 Feb;123(1):111. No abstract available. PMID: 18386365 [PubMed ‐ indexed for MEDLINE]5: Related Articles, Links Maia‐Lopes S, Castelo‐Branco M, Silva E, Villaverde C, Aguirre J, Trujillo‐Tiebas MJ, Ayuso C. Gene symbol: BEST1. Disease: Best macular dystrophy. Hum Genet. 2008 Feb;123(1):111. No abstract available. PMID: 18386364 [PubMed ‐ indexed for MEDLINE]6: Related Articles, Links Maia‐Lopes S, Castelo‐Branco M, Silva E, Villaverde C, Aguirre J, Trujillo‐Tiebas MJ, Ayuso C. Gene symbol: BEST1. Disease: Best macular dystrophy. Hum Genet. 2008 Feb;123(1):111. No abstract available. PMID: 18386360 [PubMed ‐ indexed for MEDLINE]7: Related Articles, LinksMaia‐Lopes S, Castelo‐Branco M, Silva E, Villaverde C, Aguirre J, Trujillo‐Tiebas MJ, Ayuso C. Gene symbol: BEST1. Disease: Best macular dystrophy. Hum Genet. 2008 Feb;123(1):110‐1. No abstract available. PMID: 18386356 [PubMed ‐ indexed for MEDLINE]8: Related Articles, Links Maia‐Lopes S, Castelo‐Branco M, Silva E, Villaverde C, Aguirre J, Trujillo‐Tiebas MJ, Ayuso C. Gene symbol: BEST1. Disease: Best macular dystrophy. Hum Genet. 2008 Feb;123(1):110. No abstract available. PMID: 18386355 [PubMed ‐ indexed for MEDLINE]9: Related Articles, Links Maia‐Lopes S, Castelo‐Branco M, Silva E, Villaverde C, Aguirre J, Trujillo‐Tiebas MJ, Ayuso C. Gene symbol: BEST1. Disease: Best macular dystrophy. Hum Genet. 2008 Feb;123(1):110. No abstract available. PMID: 18386350 [PubMed ‐ indexed for MEDLINE]10: Related Articles, Links Maia‐Lopes S, Silva ED, Silva MF, Reis A, Faria P, Castelo‐Branco M. Evidence of widespread retinal dysfunction in patients with stargardt disease and morphologically unaffected carrier relatives. Invest Ophthalmol Vis Sci. 2008 Mar;49(3):1191‐9. PMID: 18326749 [PubMed ‐ indexed for MEDLINE]11: Related Articles, LinksSilva MF, Maia‐Lopes S, Mateus C, Guerreiro M, Sampaio J, Faria P, Castelo‐Branco M. Retinal and cortical patterns of spatial anisotropy in contrast sensitivity tasks. Vision Res. 2008 Jan; 48(1):127‐35. Epub 2007 Dec 11. PMID: 18067943 [PubMed ‐ indexed for MEDLINE] 64 | P á g i n a
PDBEB 04/05
Publications
Trovisco V, Soares P, Preto A, de Castro IV, Lima J, Castro P, Maximo V, Botelho T, Moreira S, Meireles AM, Magalhaes J, Abrosimov A, Cameselle‐Teijeiro J, Sobrinho‐Simoes M Type and prevalence of BRAF mutations are closely associated with papillary thyroid carcinoma histotype and patientsʹ age but not with tumour aggressiveness. Virchows Arch. 2005 Jun; 446 (6):589‐95. Epub 2005 May 19. PMID: 15902486 Gago B, Nyström T, Cavaleiro C, Rocha BS, Barbosa R, Laranjinha J, Lundberg JO. “The potent vasodilator ethyl nitrite is formed upon reaction of nitrite and ethanol under gastric conditions.” Free Radic Biol Med. 45(5):404‐12 (2008) Lourenço CF, Gago B, Barbosa R, de Freitas V, Laranjinha J, “LDL isolated from plasma‐loaded red wine procyanidins resist to lipid oxidation and to tocopherol depletion” In Press in Journal of Agricultural and Food Chemistry, 2008 56(10):3798‐804 (2008) Gago B, Lundberg JO, Barbosa RM, Laranjinha J. “Red wine‐dependent reduction of nitrite to nitric oxide in the stomach.”Free Radic Biol Med. 43(9):1233‐42 (2007) Frank J, Budek A, Lundh T, Parker RS, Swanson JE, Lourenco CF, Gago B, Laranjinha J, Vessby B, Kamal‐Eldin A. “Dietary flavonoids with a catechol structure increase alpha‐tocopherol in rats and protect the vitamin from oxidation in vitro.” J Lipid Res. 47(12):2718‐25 (2006) Wang H*, Peca J*, Matsuzaki M*, Matsuzaki K, Noguchi J, Qiu L, Wang D, Zhang F, Boyden E, Deisseroth K, Kasai H, Hall WC, Feng G, Augustine GJ (2007) High‐speed mapping of synaptic connectivity using photostimulation in Channelrhodopsin‐2 transgenic mice. Proc Natl Acad Sci USA 104:8143‐8148. Arenkiel BR, Peca J, Davison IG, Feliciano C, Deisseroth K, Augustine GJ, Ehlers MD, Feng G (2007) In vivo light‐induced activation of neural circuitry in transgenic mice expressing channelrhodopsin‐2. Neuron 54:205‐218. Welch JM*, Lu J*, Rodriguiz RM, Trotta NC, Peca J, Ding J, Feliciano C, Chen M, Adam JP, Luo J, Dudek SM, Weinberg RJ, Calakos N, Wetsel WC, Feng G (2007) Cortico‐striatal synaptic defects and OCD‐like behaviors in SAPAP3 mutant mice. Nature Pitt, C. W., Valente, L. P., Rhodes, D., Simonsson, T. (2008). ʺIdentification and characterization of an essential telomeric repeat binding factor in fission yeast.ʺ J Biol Chem 283(5): 2693‐701. RM Silva, JA Paredes, GR Moura, B Manadas, T Lima‐Costa, R Rocha, I Miranda, AC Gomes, MJG Koerkamp, M Perrot, FCP Holstege, H Boucherie and MAS Santos, (2007) ʺGenetic Code Alteration Plays a Critical Role in the Evolution of Candida Genes ‐ Quantitative Analysis of Single Amino Acid Changes using a 4000 QTRAP® system.ʺ, Applied Biosystems Technical note. Miranda I, Rocha R, Santos MC, Mateus DD, Moura GR, Carreto L, Santos MA., (2007) “A Genetic Code Alteration Is a Phenotype Diversity Generator in the Human Pathogen Candida albicans.”, PLoS ONE, 2, pp. e996. Silva RM, Paredes JA, Moura GR, Manadas B, Lima‐Costa T, Rocha R, Miranda I, Gomes AC, Koerkamp MJ, Perrot M, Holstege FC, Boucherie H, Santos MA., (2007) “Critical roles for a genetic code alteration in the evolution of the genus Candida”, EMBO Journal, 26, pp. 4555. Fertuzinhos SM, Oliveira JR, Nishimura AL, Pontual D, Carvalho DR, Sougey EB, Otto PA, Zatz M. Analysis of IL‐
1alpha, IL‐1beta, and IL‐1RA [correction of IL‐RA] polymorphisms in dysthymia. J Mol 65 | P á g i n a
Neurosci. 2004;22(3):251‐6. ‐Zhou, Xiang*; Babu, J.Ramesh*; da Silva, Susana*; Shu, Qing; Graef, Isabella A.; Oliver, Tim; Tomoda, Toshifumi; Tani, Tomomi; Wooten, Marie W.; and Fan Wang; Unc‐51‐like kinase 1/2‐mediated endocytic processes regulate filopodia extension and branching of sensory axons; PNAS; 104(14):5842‐5847; 2007 * these authors contributed equally to this work 66 | P á g i n a
12. Funding Private funding (Fundação para a Ciência e Tecnologia, Sanofi, Biogen Idec, Crioestaminal, Dias de Sousa S.A, I.L.C – Instrumentos de Laboratório e Científicos Lda, Reagente 5, Grupo Taper, Frilabo) Funding from FCT has become unsufficient to maintain the demands of an international education on the cutting edge subjects of biomedicine and biology. To overcome the finantial constraints the programme has attracted funding from non‐governmental sources, namely Sanofi, Biogen Idec. 67 | P á g i n a
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Annex 1
Programe of the Joint Meeting of Graduate Programmes on Biosciences
SECOND JOINT MEETING OF GRADUATE PROGRAMMES ON BIOSCIENCES Portugal Hotel dos Templários, Tomar, December 18‐21, 2005 ( www.hoteldostemplarios.pt ) 69 | P á g i n a
Sunday, 18th 16.00h Opening Session 16.15h Neurobiology (I) Chairperson: Carlos B. Duarte (Coimbra) 16.15h: Plasticity of dendrodendritic transmission between mitral cells in the mammalian olfactory bulb Pimentel, Diogo ‐ PGDB 16.35h: Melanopsin structure & function: a comparative analysis Pires, Susana – GABBA 16.55h: Role of Nkx2‐1 transcription factor in the specification of subpallial GABAergic interneurons Pereira, Sandrina Nóbrega – PDBEB 17.15h: Role of transforming growth factor beta (TGF‐β) in oligodendrocyte biology Correia, Ricardo ‐ PDBEB 17.35h: Physiological function of the Prion Protein (PrP) in the immune system Oliveira Martins, José ‐ PGDB 18.00h Coffee Break Molecular Cell Biology Chairperson: Sukalyan Chatterjee (Oeiras) 16.15h: Aurora A phosphorylates D‐TACC at the centrosome to stabilize centrosomal MTs Barros, Teresa P. ‐ GABBA 16.35h: Cell polarity and axis formation: regulation of microtubules in the Drosophila oocyte
Raposo, Alexandre – PGDB 16.55h: Regulation of proton flux pattern by cytoskeleton dynamics in pollen tubes Costa, Sílvia ‐ PGDB 17.15h: The central role of FLC in the control of Arabidopsis flowering time Geraldo, Nuno – PGDB 17.35h: Mechanisms that govern Rac dynamics Pacheco, Alexandra ‐ PGDB 18.30h Plenary Lecture #1 Spencer Wells National Geographic Society 20.00h Reception and Dinner 70 | P á g i n a
Monday, 19th 9.00h
Nuclear Biology Chairperson: Miguel Godinho Ferreira (Oeiras) 9.00h: A role for Trf4/5 in regulating RNA levels Reis, Clara – PGDB 9.20h: A second requirement for RNA pol II in Influenza Virus lifecycle Amorim, Maria João – PGDB 9.40h: Localisation, regulation and activity of DNA replication origins in mammals Mendes, Joana – PDBEB 10.00h: A biochemical approach for determining the role of Zeste in Polycomb and Trithorax function Antão, José ‐ PGDB Developmental Biology (I) Chairperson: Leonor Saúde (Oeiras) 9.00h: Odd‐family genes are required for retinal differentiation initiation and correct eye morphogenesis Brás‐Pereira, Catarina – PDBEB 9.20h: Rho and its effector diaphanous regulate adherens junctions Homem, Catarina ‐ PGDB 9.40h: The role of FGF signaling during cardiac development Marques, Sara ‐ GABBA 10.00h: Long range signalling of TGF‐ type morphogens in the Xenopus embryo Hagemann, Anja I. ‐ PGDB 10.20h: Respiration and ageing in C.elegans Cristina, David – PGD
10.40h Coffee Break Cell Cycle Chairperson: Miguel Godinho Ferreira (Oeiras) 11.10h: Mating in yeast Sá, Joana ‐ PGDB 11.30h: Condensin I is essential for the structural integrity of centromeric heterochromatin during mitosis Oliveira, Raquel A. ‐ PDBEB 11:50h: Genetic and biochemical analysis of mitotic chromosomes Tadeu, Ana Mafalda ‐ PDBEB 12:10h: Molecular partners for Bud6p‐mediated orientation of the mitotic spindle in S. cerevisiae Lopes, Cláudia S. J. – PGDB 12.30h: Spatial & temporal control of the cell cycle Mendes Pinto, Inês ‐ GABBA Immunology (I) Chairperson: Margarida Correia‐Neves (Porto) 11.10h: Identification and characterization of an atypical CD8 T‐cell response leading to monoclonal deletion Evaristo, César – PGDB 11.30h: T cell‐mediated immunosuppression in retroviral infection Antunes, Inês – PGDB 11.50h: Modulation of the CD4+ T cell response to a dominant L. Major antigen through dendritic cell targeting Soares, Helena – PGDB 12.10h: Molecular mechanisms implicated in T lymphocyte polarisation and locomotion Real, Eliana – PGDB 71 | P á g i n a
12.30h: IFN‐gamma regulates the differentition of IL‐
17 producing T cells Cruz, Andrea ‐ GABBA Monday, 19th 13.00h: Lunch 14.00h: Posters 15.30h
Neurobiology (II) Chairperson: Rodrigo Cunha (Coimbra) 15.30h: The role of the A‐kinase anchoring protein in neuron plasticity and memory formation Spasikova, Marija ‐ PGDB 15.50h: 16.10h: A role for CBP and p300 on long‐term memory formation Oliveira, Ana MM – PGDB 19.00h: Plenary Lecture #2 Allan Bradley Sanger Institute, Cambridge, UK 20.00h: Dinner and entertainment
The organiz formation of lifelong memories in the cortex Teixeira, Cátia – GABBA 16.30h: Transcriptional analysis of sex differences in long term memory formation Antunes‐Martins, Ana – GABBA 17.00h: Coffee Break Oncobiology 17.30h Chairperson: Fátima Carneiro (Porto) Mechanisms of Disease (I) Chairperson: Luís Almeida (Coimbra) 17.30h: 17.50h: Study of the wild‐type huntingtin’s physiologic function through an evolutionary approach Ramos, Catarina ‐ GABBA Molecular and genetic approaches to understand mechanisms of polyglutamine induced neurodegeneration Branco, Joana ‐ GABBA 18.10h: Host cell response to Plasmodium infection Albuquerque, Sónia S. ‐ GABBA 18.30h: 3 1‐integrin deficiency promotes VEGF specific angiogenesis Silva, Rita ‐ PGDB 15.30h: Evaluation of Numerical Chromosome Aberrations in Glioma Tumours as Revealed by Interphase Fluorescence In Situ Hybridization Vital, Ana Luísa ‐ PDBEB 15.50h: Histone modifications at the promoter of tumor suppressor genes Jacinto, Filipe V. ‐ GABBA 16:10h: The involvement of vascular/ endothelial compartment in the bone marrow recovery post‐irradiation Ferreira, Manuela ‐ PDBEB 16:30h: Identification of molecular mechanisms that link E‐cadherin missense mutations with cell invasion Ferreira, Paulo – GABBA 72 | P á g i n a
Virology Chairperson: Sofia Corte‐Real (Porto) 17.30h: Analysis of Herpes simplex virus type 1 tegument acquisition during virus egress Souto, Raquel ‐ GABBA 17.50h: Evaluation of Rota Virus‐like Particles (VLPs) Immune Response in Animal Models Istrate, Cláudia ‐ PGDB 18.10h: Functional conservation between yeast Dhh1 and human Rck/p54 in brome mosaic virus RNA replication Alves‐Rodrigues, Isabel ‐ GABBA 73 | P á g i n a
Tuesday, 20th Evolution Chairperson: Raquel Silva (Porto) 9.00h: Evolution of eukaryotic protein interaction networks Beltrao, Pedro – GABBA 9.20h: Fast‐X evolution in Drosophila Viçoso, Beatriz – GABBA 9.40h: Whole genome survey of copy number polymorphisms in Drosophila melanogaster and D. simulans Moreira, Margarida – GABBA 10.00h: Was Darwin wrong? Ferreira, Álvaro ‐ PGDB 10.20h Coffee Break Molecular Diagnosis and Therapy Chairperson: Luís Graça (Oeiras) 10.40h: Application of infrared spectroscopy and chemometric techniques in the rapid identification of pathogenic microorganisms Preisner, Ornella ‐ PGDB 11.10h: Injectable delivery of angiogenic molecules Silva, Eduardo A. ‐ PGDB 11.30h: Antagonist G peptide mediated uptake of liposomes containing Bcl‐2 antisense oligonucleotides in small cell lung cancer cells Santos, Adriana ‐ PDBEB
Microbiology & Parasitology Chairperson: Milton Costa (Coimbra) 9.00h: Characterization of the biosynthetic pathway of glucosylglycerate in the archaeon METHANOCOCCOIDES BURTONII Costa, Joana ‐ PDBEB 9.20h: Analysis of epigenetic factors that control expression of rRNA genes in Plasmodium parasites Silva, Liliana Mancio ‐ GABBA 9.40h: Effects of livestock ownership on malaria risk: an epidemiological study in Ethiopia Franco, Ana – PGDB 74 | P á g i n a
Behavioural Neuroscience Chairperson: Miguel C. Branco (Coimbra) 10.40h: Mental time travel in the western scrub‐jay? The prospective cognition of caching Correia, Sérgio Pereira de Carvalho ‐ PGDB 11.00h: Development and skill acquisition in infant and juvenile baboons Morais, Inês Canavarro – PGDB 75 | P á g i n a
Tuesday, 20th Stem Cells (I) Mechanisms of Disease (II) Chairperson: António Jacinto (Oeiras) 12.00h: Developing human embryonic stem cell‐
based therapy for Parkinson’s disease Correia, Ana Sofia ‐ PGDB Chairperson: Miguel Seabra (Oeiras) 12.00h: High glucose causes caspase‐independent apoptotic cell death in retinal neural cells Santiago, Ana R. ‐ PDBEB 12.20h: 12.40h: 12.20h: X‐chromosome inactivation in human embryonic stem cells Silva, Susana Santos ‐ PGDB Atropine inhibits postprandial insulin sensitivity in a dose dependent manner Patarrão, Rita ‐ GABBA 12.40h: Regulation of apoptosis by p53 in human embryonic stem cells Grandela, Catarina ‐ PDBEB Leukocyte adhesion and blood‐retinal barrier breakdown in diabetic retinopathy: role of nitric oxide Leal, Ermelindo C. ‐ PDBEB 13.00h: A Funcional RNAi screen for Embryonic Stem Cell transcriptional regulatory networks Maia, Alexandre Gaspar – PDBEB 13.00h: Biological significance of cancer associated sialyl‐Tn antigen: modulation of malignant phenotype in gastric carcinoma cells Marcos, Nuno – GABBA
13.20h: Lunch Neurobiology (III) 14.00h: Posters Chairperson: Ana Luísa Carvalho (Coimbra) 15.30h: Axonal guidance cues in the development of the accessory olfactory system Mendes da Silva, David ‐ PDBEB 15.30h Developmental Biology (II) Chairperson: António Jacinto (Oeiras) 15.30h: Nodal signaling and early left‐right morphogenesis of the Zebrafish heart Baptista, Inês ‐ PGDB 15.50h: The function and regulation of the imprinted gene Delta‐like 1 (Dlk1) in mouse development Teixeira da Rocha, Simao ‐ GABBA 16.10h: Notch: signalling and interactions Fiúza, Ulla‐Maj ‐ PGDB 16.30h: Deciphering the notch transcriptional code in C.elegans Neves, Alexandre ‐ PGDB 16.50h: A study of the TGF signalling adapter SARA Campos, Cláudia – PGDB 17.10h: 15.50h: Analysis of olfactory bulb interneuron diversity and the effects of activity during adult neurogenesis Brito, Renata ‐ PGDB 16.10h: 16.30h: Down regulation of EphA3 receptor activity by ephrin‐A5 in cis Carvalho, Ricardo ‐ PGDB The role of electric activity on axon regeneration Enes, Joana ‐ PGDB 16.50h: Transthyretin is involved in nerve regeneration Fleming, Carolina Estima – PDBEB 17.10h Shh and the regulation of neural progenitor properties Cruz, Catarina – PDBEB Looking for inputs of the Sav‐Hpo‐Wts signaling pathway Josué, Filipe – PDBEB 17.30h: Coffee Break 18.00h
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Neurobiology (IV) RNA Biology Chairperson: Miguel C. Branco (Coimbra) 18.00h: 18.20h: 18.40h: 19.00h: Chairperson: Alexandra Moreira (Porto) Neurogenetic analysis of learning and memory using zebrafish as a model system Valente, André – PGDB In vitro dynamics and homeostatic plasticity: why do cultured cortical networks develop bursts? Carvalho, Tiago P. ‐ PGDB 18.00h: Analysis of the role of argonaute proteins in the Caenohabditis elegans RNAi pathway Batista, Pedro – PGDB 18.40h: How does localization determine mRNA biology? Andrade, Gonçalo – GABBA In vivo assessments of neural circuit dysfunction in depression Oliveira‐Maia, Albino J. – GABBA Visual perception in humans – from physiological assymmetries in sensory maps to functional impairment in genetic models of photoreceptor degeneration Maia‐Lopes, Susana ‐ PDBEB 20.00h: Dinner 18.20h: Exploring links between RNA processing & turnover and RNA interference in fission yeast Almeida, Ricardo – PGDB 19.00h: Mechanism and Control of Mrna turnover in yeast: Characterization of Processing bodies Teixeira, Daniela ‐ GABBA 21.30h: Plenary Session on Communication Ana Noronha Ciência Viva Nuno Crato ISEG Instituto Superior Economia e Gestão Dept. of Maths 77 | P á g i n a
Wednesday, 21st 9.00h Immunology (II) Cell Fate Chairperson: Fernando Arosa (Porto) Chairperson: Miguel Seabra (Oeiras) 9.00h: 9.20h: 9.40h: Virus exploitation of Toll‐like receptors (TLRs) signaling Oliveira, Vivian – PGDB The roles of A20 and ubiquitylation in regulating TLR signaling and innate immune function Tavares, Rita – PGDB Reversible inhibition of heme oxygenase‐1 expression in mice Tokaji, László – PGDB 10.00h: Restriction of L. pneumophila growth by murine dendritic cells Nogueira, Catarina ‐ GABBA 10.20h: Conditional silencing of HLA expression Figueiredo, Constança – PDBEB 9.00h: Epigenetic regulation of blastocyst lineage specification Santos, Joana – PGDB 9.20h: Bipolar cell fate in the Zebrafish retina Vitorino, Marta – PGDB 9.40h: Dephosphorylation of Bim during mitotic exit Mena, Ana ‐ PGDB 10.00h: Inhibitor of apoptosis proteins and modulation of caspase activity in Drosophila malanogaster Ribeiro, Paulo S. ‐ PGDB 10.40h: Coffee Break 11.10h Neurobiology (V) Chairperson: José Castro‐Lopes (Porto) 11.10h: 11.30h: 11.50h:
12.10h:
12.30h:
Dynamic properties of neuroligin‐1 trafficking Peixoto, Rui ‐ PGDB New interactors for GluR4 and GluR2L AMPA receptor subunits Santos, Sandra D. ‐ PDBEB BDNF induces the synaptic delivery of AMPA receptors and enhances NMDA receptor activity in hippocampal neurons Caldeira, Margarida V. ‐ PDBEB The role of Nogo‐A in the CNS: a genomic and proteomic approach Craveiro Luis M. ‐ GABBA The Role of the Developmentally Regulated Brain Protein in Growth Cone Pathfinding Geraldo, Sara ‐ PGDB Stem Cells (II) Chairperson: João Ramalho‐Santos (Coimbra) 11.10h: Role of p63 in epithelial stem cell maintenance Pinto, Filipa ‐ PGDB 11.30h: Transcriptional programming in quiescent human hematopoietic stem cells Pina, Cristina ‐ PGDB
11.50h: Liver regeneration and tissue engineering with amniotic fluid stem cells and a novel whole organ bioscaffold Baptista, Pedro ‐ PGDB 12.10h: Chromatin events that underlyie the reprogramming of a somatic cell after fusion with muscle cells and embryonic stem cells Pereira, Filipe – GABBA 12.30h: The role and regulation of PCG proteins in early mouse development and stem cell plasticity Casanova, Miguel ‐ GABBA 78 | P á g i n a
Wednesday, 21st 13.00h: Lunch 14.00h: Posters 15.00h: Closing Ceremony
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POSTERS P1: Engineering a cell‐cycle counter for the study of aging Afonso, Bruno ‐ GABBA P2: Regulation of angiogenesis by Távora, Bernardo ‐ PGDB P3: Computational analysis of the evolution and regulation of alternative splicing in metazoan Corvelo, André – GABBA P4: Dissecting host‐parasite coevolution with ecological genomics Vale, Pedro ‐ GABBA P5: The relationship between genome structure and genic evolution: effects of chromosomal rearrangements on evolutionary rates and speciation Fernando, Olga – PGDB 3D‐structure determination of the translational factors that mediate a genetic code change in the human pathogen Candida albicans Rocha, Rita – PDBEB P7: HmrA‐mediated methicillin‐resistance in Staphylococcus aureus P6: ‐integrin Botelho, Tiago ‐ PGDB P8: Implications of HIF regulation, by ubiquitin‐proteasome pathway, in angiogenesis associated to diabetic retinopathy Bento, Carla – PDBEB P9: Nitric oxide and nitrite in the gastrointestinal tract: redox interactions with potential implications in gastric cancer Gago, Bruno ‐ PDBEB P10: The role of nonsense‐mediated mRNA decay (NMD) in the regulation of cdh1 gene expression and implications in gastric cancer development Karam, Rachid – GABBA P11: Exploring the role of E‐cadherin trafficking deregulation in epithelial cancer progression Correia, Joana – GABBA P12: In vivo cell migration studies using the wound inflammatory response in the zebrafish larvae as a model Moreira, Severina – PGDB P13: Molecular regulation of microtubules In Drosophila Meireles, Ana M – PDBEB P14: Analysis of the molecular interactions of Prp8 splicing factor in yeast Cristão, Vanessa – PGDB P15: Foxp3 in transplantation tolerance Regateiro, Frederico – PGDB P16: Foxp3 expression in T cell ontogeny – from embryonic development to vertebrate evolution Duarte, João H ‐ PDBEB P17: Infection of the thymus by mycobacteria: Potential consequences on chemotherapy and immune response to infection Nóbrega, Cláudia – GABBA P18: Study of the mechanisms and function of memory reconsolidation Proença, Cátia – PGDB P19: Roles of postsynaptic scaffolding proteins in regulating the formation of neuronal cholinergic synapses Feliciano, Cátia – PGDB P20: Development mechanisms regulating the branching morphogenesis of axons and dendrites Silva, Susana da ‐ PDBEB P21: Development of a genetically encoded probe for postsynaptic calcium Oliveira, Ana – PDBEB 80 | P á g i n a
P22: Functional Proteomic Analysis of Synaptic Scaffolding Proteins Peça, João – PDBEB P23: Molecular control of pyramidal cell identity and connectivity Fertuzinhos, Sofia – PDBEB P24: Neuronal dynamics on social interactions Marreiros, André Costa ‐ PGDB P25: Mitotic Spindle Morphogenesis: the role of an acentrosomal pathway in animal somatic cells Moutinho‐Pereira, Sara – GABBA P26: Unravelling telomere chromatin structure in S. pombe Valente, Luis – PDBEB P27: Studies into the transcriptional network surrounding Runx1 at the onset of haemopoiesis Santos, Ana Cristina – PGDB P28: Genes controlling apoptotic cell clearance in Caenorharditis elegans Pinto, Sérgio M – GABBA P29: The nucleocytoplasmic shuttling activity of the splicing factor U2AF and its post‐splicing effects on mRNA fate Keusch, Sarah ‐ PGDB P30: Circunferential ascending interneurons (CIA) specification in the zebrafish spinal cord Batista, Manuel – PGDB P31: The genetic regulatory network underlying neuronal development in the ascidian embryo Sobral, Daniel – PGDB P32: Establishing the transcriptional regulatory networks controlling development of the myocardium Simões, Ana Filipa – PDBEB P33: Epigenetic regulation of human embryonic stem cell identity Pinho, Sandra – GABBA P34: A genetic screen to identify new genes required for the anterior localization of bicoid mRNA in the Drosophila oocyte. Morais‐de‐Sá, Eurico – GABBA P35: Functional comparative analysis of the Odd/Osr genes during the development of the renal structures Neto, Ana – GABBA P36: The PI3K pathway and intrinsic mechanisms of organ size control in Drosphila wing development Neto Silva, Ricardo M. – PGDB P37: Analysis of cell behaviour during GBE in drosophila embryos Mateus, Ana – PGDB P38: How do lipids regulate growth? Almeida de Carvalho, Maria João ‐ PGDB P39: Alterations of the antigen processing machinery upon HIV infection Alves, Pedro – GABBA
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Annex 2
Programe of the Annual Meeting of the PhD Programme of Experimental Biology and
Biomedicine
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Saturday, 16th December 2006 08.45: Registration 09.00: Welcome ‐ Catarina Resende de Oliveira [President of CNC] Carlos Faro [Scientific Director of Biocant] Session I Chairpersons: Miguel Castelo Branco | Ana Cristina Rego 09.30: Carolina Fleming | Transthyretin Enhances Nerve Regeneration 09.45: Mafalda Mendes | Hierarchical Phenotyping of the Visual System: Application to Williams Syndrome 10.00: Rosa Resende | Neuronal Susceptibility to Different Assemblies of ABeta Peptide 10.15: Susana Lopes | Mechanisms of Neurosensory Disease in Humans: From Normal Visual Asymmetries to Functional Impairment in Genetic Models of Photoreceptor Degeneration 10.30: Jorge Oliveira | Mitochondrial‐Dependent Calcium Handling in Huntington’s Disease Striatal Cells: Effect of Histone Deacetylase Inhibitors 10.45‐11.15: Coffee Break and Poster Viewing Session II Chairpersons: Carlos Duarte | João Ramalho Santos 11.15: Alexandra Amaral | Regutation of Mitochondrial DNA Content in Human Sperm: Implications for Male (IN) Fertility 11.30: Ana Filipa Simões | NKX2.7 Modulates the Boundary Between Heart and Blood Fields 11.45: Ana Sousa | What is the Function of Kinesin‐73 in Development? 12.00: Catarina Cruz | Transcriptional Profiling a Morphogen: Analysis of Gene Expression in Neural Cells Responding to Graded Sonic Hedgehog 12.15: David Silva | Expression of Repulsive Guidance Molecules in the Developing Olfactory Systems 12.30: Raquel Oliveira | Condensin I Displays a Highly Dynamic Association with Mitotic Chromosomes During Drosophila Early Embryonic Divisions 12.45: Alexandre Maia | Identification of Novel ES Cell Regulators Using a RNAi Screen 13.00‐14.15: Lunch Session III Chairpersons: Caetana Carvalho | Emília Duarte 14.15: Joana Salgado | Interleukin‐1b Stimulates Catecholamine Release in Human Chromaffin Cells: Roles of Nitric Oxide and Neuropeptide Y 14.30: João Duarte | Relation between CB1 cannabinoid receptors and hippocampal metabolism 14.45: Sandrina Pereira | Postmitotic NKX2‐1 expression controls the segregation of striatal and cortical interneurons in the developing telencephalon 15.00: Margarida Caldeira | BDNF Regulates the Expression and Traffic of NMDA Receptors in Cultured Hippocampal Neurons 15.15: João Peça | Functional Analysis of Synaptic Scaffolding Proteins 15.30‐16.30: Coffee Break and Poster Discussion [poster 1 to 12] ‐ Chairpersons: Cláudia Pereira| Sandra Cardoso | Fabienne Agasse | Armanda Santos Session IV Chairpersons: Celeste Lopes | Milton Costa 16.30: Ana Luísa Vital | Identification of Intratumoral Patterns of Clonal Evolution in Gliomas 16.45: Manuela Ferreira | The Role of β1 Integrin T188I Mutation in the Epithelial Tumour Development 17.00: João Henrique Duarte | FOXP3 in Regulatory T Cell Physiology 17.15: Marta Viegas | CD38 Ectoenzyme: Role in Mycobacterial Infections and Systemic Autoimmunity. 17.30: Joana Costa | Elucidation of the Biosynthetic Pathway for Glucosyglycerate in Cold‐ and Heat‐Adapted Microorganisms. Hints for Cryo/Thermal Protection 83 | P á g i n a
17.45: Susana Alarico | An Extermely Thermostable Trehalose‐Hydrolysing a‐Glucosidase from Thermus Thermophilus HB27 18.00‐18.15: Break 18.15‐19.00: Lecture Molecular Biology of HIV‐1 Infection in non‐dividing Cells.‰ Jean‐Marc Jacqué, University College Dublin 19.45: Dinner at Restaurante Fininho Sunday, 17th December 2006 Session V Chairpersons: Carlos Faro | João Nuno Moreira 09.30: Adriana Santos | Evaluation of Different BCL2 Gene Silencing Approaches Against Small Cell Lung Cancer 09.45: Constança Figueiredo | Controlling HLA Expression to Reduce Immunogenicity of Cell‐Based Therapies 10.00: Sandro Alves | Modelling and Gene Silencing in Machado‐Joseph Disease 10.15: Rita Rocha | The molecular mechanism for CUG decoding in the human pathogen Candida albicans 10.30: Silvia Neves | Evaluation of Herpes Simplex Virus Thymidine Kinase/Ganciclovir Therapy Mediated by Transferrin‐Associated Lipoplexes in a Murine Model for Oral Cancer 10.45‐11.45: Coffee Break and Poster Discussion [poster 13 to 25] ‐ Chairpersons: Eugénia Carvalho | Paulo Oliveira | Paula Agostinho | Teresa Gonçalves Session VI Chairpersons: João Malva | Claudia Cavadas 11.45: Liliana Bernardino | Tumor Necrosis Factor‐Alpha Induces Neurogenesis In Subventricular Zone Cell Cultures 12.00 João Gomes | Calpain Cleaves the Vesicular GABA Transporter (VGAT), Into a New Stable Form, Under Excitotoxic Conditions and In‐Vivo Ischemia 12.15: Sara Xapelli | Neuroprotection by NPY and BDNF against excitotoxicity in mouse hippocampal slice cultures 12.30: Sandra Santos | Identification of New Binding Partners for AMPA Receptors 12.45: Susana Silva | Formins Regulate Actin during Neuronal Morphogenesis 12.45‐14.00: Lunch Session VII Chairpersons: João Laranjinha | John Jones 14.00: Giovannia Pereira | Lanthanide (III) Containing Nanoparticles as Potential MRI Contrast Agents 14.30: Bruno Gago | Dynamics of NO production in the stomach from nitrite promoted by dietary phenols 14.45: Vilma Sardão | Morphological Endpoints of Cell Death Upon Exposure of H9c2 Embryonic Ventricular Cells to Tert‐ Butylhydroperoxide 15.00: Luís Valente | Unravelling Telomere Chromatin Structure in S. Pombe 15.15: Joana Mendes | Specification of DNA Replication Origins in the Mouse Genome 15.30: Filipe Josué | Identifying Novel Components of the Hippo Pathway 15.30‐16.30: Coffee Break and Poster Discussion [poster 26 to 38] ‐ Chairpersons: Alexandrina Mendes| Teresa Martins | Paula Veríssimo | Otília Vieira Session VIII Chairpersons: Francisco Ambrósio | Leonor Almeida 16.30: Bruno Silva | Isolated brain mitochondria are affected by compounds from Hypericum perforatum contributing to protect neurons from excitotoxic insults 16.45: Ana Raquel Santiago | Apoptosis‐Inducing Factor Mediates High Glucose‐Induced Cell Death in Retinal Neural Cells 17.00: Ermelindo Leal | High Glucose, Nitric Oxide and H2O2 Induce Apoptosis by A Caspase‐Independent Pathway in Retinal Endothelial Cells 17.15: Carla Bento | Methylglyoxal Destabilizes HIF‐1 by an Ubiquitin‐Dependent Pathway and Imbalances the ANG‐2/VEGF Levels: Implications for Diabetic Retinopathy 84 | P á g i n a
17.30: Sofia Fertuzinhos | Distinct Subclass of Cerebral Cortical Gabaergic Interneurons is absent or Reduced in Human Holoprosencephaly 17.45‐18.00: Closing Remarks ‐ Euclides Pires [Vice‐President] 85 | P á g i n a
Thursday, 20th December 2007 08.45: Registration 09.00: Welcome ‐ Catarina Resende de Oliveira [President of CNC] Session I – Neuroscience and disease Chairpersons: João Malva | Ana Cristina Rego 09.40: Paula Canas | Adenosine A2A receptor blockade prevents memory dysfunction caused by ‐amyloid peptides but not by scopolamine or MK‐801 10.00: Elisabete Ferreiro | Cross‐talk between endoplasmic reticulum and mitochondria in the neurotoxicity induced by beta‐amyloid and prion peptides. Implications for ethiopathognesis of alzheimer’s disease and prion disorders 10.20: Mario Laço | Great partners do not work together – studies on ataxin‐3 and HHR23A interaction 10.40‐11.40: Coffee Break and Poster Discussion [poster 1 to 12] ‐ Chairpersons: Paula Agostinho | Rui Brito | Armanda Santos | Paulo Santos | Inês Araújo | Sérgio Simões Session II – Neuroscience and disease Chairpersons: Emília Duarte | Rodrigo Cunha 11.40: Sofia Fertuzinhos | Subtype‐specific loss of cortical interneurons in human holoprosencephaly with severe ventral forebrain hypoplasia 12.00: Sandrina Nobrega | Postmitotic NKX2‐1 controls the segregation of cortical and striatal interneurons in the developing telencephalon 12.20: Susana da Silva | Target‐derived BMP signal in the formation of the trigeminal sensory map 12.40: Ana Oliveira | The role of neurofibromin in spine morphology and plasticity 13.00‐14.20: Lunch and Poster Viewing Session III – Biotechnology and Microbiology Chairpersons: Carlos Faro | Milton Costa 14.20: Ana Luísa Cardoso | siRNA delivery to the CNS by TF‐lipoplex‐mediated gene silencing in vitro and in vivo 14.40: Cândida Silva | P‐found: a global repository for protein folding and unfolding simulation data 15.00: Rita Rocha | the crystal structure of Candida albicans Seryl‐tRNA synthetase: implications for CUG codon reassignement 15.20: Chantal Fernandes | Glucosylglycerate occurrence, Biosynthesis and protein stabilization 15.40‐16.40: Coffee Break and Poster Discussion [poster 13 to 25] ‐ Chairpersons: Celeste Lopes | Paulo Oliveira | Claúdia Pereira | Teresa Gonçalves | Teresa Diniz | Paula Moreira Session IV – Toxicology and NMR Chairpersons: João Laranjinha | John Jones 16.40: Bruno Gago | Nitrite in the biology of *NO in the stomach: production of a vasoactive compound in the presence of red wine 17.00: Vilma Sardão | Mechanisms of doxorubicin‐induced H9c2 myoblast death – involvement of p53/bax pathways and oxidative stress 17.20: Ana Francisca Soares | Sources of hepatic glycogen synthesis in overnight‐fed rats using deuterated water tracer 17.40‐18.00: Teresa Delgado | The effects of a high fat diet on hepatic triglyceride levels and sources in the adult rat 18.00‐18.20: Break 86 | P á g i n a
18.20‐19.00: Lecture Chiara Zuccato | The role of huntingtin in neuronal gene transcription and its altered function in Huntington’s Disease 19.00‐19.30: Arsélio Pato de Carvalho [Honorary President of CNC] | Graduate Schools at Research Universities 19.45: Dinner at Restaurante Porquinho 87 | P á g i n a
Friday, 21th December 2007
Session V – Stem cells & Development Biology Chairpersons: João Ramalho Santos | Ana Luísa Carvalho 09.00: Alexandre Gaspar‐Maia | An RNAi screen reveals the chromatin remodelling factor Chd1 as a new regulator of ES cells 09.20: Sandra Varum | Inhibition of complex III of mitochondrial respiratory chain maintains HES cells in a pluripotent state 09.40: Catarina Cruz | Specification of the vertebrate floor plate: involvement of the transcription factor FOXJ1 and a programme of motile ciliogenesis 10.00: Luís Valente | Characterization of an essential Fission Yeast gene containing MYB domains 10.20‐11.20: Coffee Break and Poster Discussion [poster 26 to 38] ‐ Chairpersons: João Nuno Moreira | Teresa Martins | Teresa Cruz | Otília Vieira | Claudia Cavadas | Rui de Carvalho Session VI – Retinal biology and Diabetes Chairpersons: Francisco Ambrósio | Sancha Santos 11.20: Ana Rita Álvaro | Neuropeptide Y stimulates retinal cells proliferation – involvement of nitric oxide 11.40: Susana Maia Lopes | Novel psychophysical, electrophysiological and genotyping methods applied to inherited retinal degenerations:genotype‐phenotype correlations 12.00: Célia Aveleira | Pro‐inflammatory Cytokines‐induced increase in retinal endothelial cell permeability: protective effect of dexamethasone 12.20: João Duarte | Molecular and metabolic alterations in the diabetic hippocampus are prevented by chronic caffeine consumption 12.40: Carla Bento | Methyglyoxal takes HIF’s breath away 13.00‐14.00: Lunch Session VII ‐ Oncobiology and Immunology Chairpersons: Conceição Pedroso Lima | Sukalyan Chaterjee 14.00: Ana Luísa Vital | Intratumoral patterns of clonal evolution and genetic profile in gliomas. 14.20: Manuela Ferreira| The role of Beta 1 integrin T1881 mutation on the epithelial tumour development 14.40: Adriana Santos | Targeted therapeutics in SCLC – Bcl2 revisited 15.00: Rui Nobre | Complete genotyping of mucosal human papillomavirus in Portuguese population using a novel PCR‐RFLP methodology and an original typing algorithm 15.20: Marta S. Viegas | CD38 ectoenzyme: role in mycobacterial infection and systemic autoimmunity 15.40: João Duarte | FOXP3 expression by regulatory T cells is labile and conditions their function 15.40‐16.40: Coffee Break and Poster Discussion [poster 39 to 53] ‐ Chairpersons: Paula Veríssimo | Nuno Empadinhas | José Custódio | Armando Cristóvão | Raquel Seiça | Atila Kofalvi Session VIII ‐ Cell & Development Biology Chairpersons: Caetana Carvalho | Carlos Duarte 16.40: Ana Meireles | Microtubule associated proteins targeted RNAi screen reveals 21 new microtubules regulators 17.00: Ana Filipa Simões | Exploring the evolutionary relationship between cardiac and blood/endothelial precursors 17.20: Filipe Josué | A genome‐wide RNAi screen for modulators of SWH signalling 17.40: Joana Sequeira Mendes | Epigenetic specification of DNA replication origins in the mouse genome 18.00: Joana Ferreira | Characterization of alternatively spliced isoforms of AMPA receptor subunits encoding truncated receptors 18.20: Sandra Santos | Contactin and CASPR: new binding partners for AMPA receptors 18.40‐19.00: Closing Remarks ‐ Euclides Pires [Vice‐President] 88 | P á g i n a
VI ENCONTRO ANUAL DO CNC Reunião Anual do Programa Doutoral em Biologia Experimental e Biomedicina 16‐17 Dezembro 2008 Biocant Park | Cantanhede 89 | P á g i n a
16th December 2008 PROGRAMME 08.45: Registration 09.10: Introductions & Welcome ‐ Catarina Resende de Oliveira [CNC President] Session I – Molecular Biotechnologies Chairpersons: Nuno Empadinhas | Luís Pereira de Almeida 09.40: Henrique Faneca (Ciência 2007) | Antitumoral gene therapy strategies combined with chemotherapeutic agents 10.00: Isabel Nascimento Ferreira | Lentiviral delivery of beclin‐1 in the rat brain reduces neuronal dysfunction and neurodegeneration associated with Machado‐Joseph Disease 10.20: Mariana Bexiga | Nanoparticles as possible drug delivery vectors to the brain 10.40: Vítor Mendes | Biosynthesis of the methylglucose lipopolysaccharide in Mycobacterium tubercolosis. Identification of genes and characterization of enzymes 11.00‐11.30: Coffee Break Session II – Neurons and the brain Chairpersons: Fabienne Agasse| Rodrigo Cunha 11.30: Ana Rita Santos | BDNF‐induced changes in the proteome of cultured hyppocampal neurons: Genomic and proteomic effects on the translational machinery 11.50: João R. Gomes | Exitotoxic damage downregulates TrkB signalling and upregulates the truncated form of TrkB in cultured hippocampal and striated neurons 12.10: Ricardo Marques | Functional significance of excitatory local neurons in the antennal lobe of the fruit fly 12.30: Ricardo M. Santos | Nitric oxide in the rat brain: Insights into the modulation of its inactivation in vivo 12.30‐14.00: Lunch Session III – Stem Cells and Development Chairpersons: Lino Ferreira | Carlos Duarte 14.00: Alexandra Rosa | Role of angiogenic factor angiopoietin‐1 in the SVZ stem cell niche 14.20: Sofia Grade | Functional identification of SVZ‐derived oligodendrocytes based on selective response to thrombin 14.40: Bruno P. Carreira| Nitric oxide as a modulator of neural stem cell proliferation 15.00: Ana Filipa Simões | How to flip the blood programme into the heart programme 15.20: Joana F. Neves | γδ Cell receptor requirements for thymic γδ cell development 15.40‐16.10: Coffee Break Session IV –Development & Cells Chairpersons: Otília Vieira | Inês Araújo 16.10: Ana Soares | Identification of novel zebrafish microRNAs using massive parallel DNA sequencing 16.30: Sara Sousa| The origin and dynamics of blastemal cells during zebrafish caudal fin regeneration 16.50: Carina S. S. Gomes‐Santos | Actin dynamics in Plasmodium sp. infected hepatocyes 17.10: Luís Valente | Myb‐domain protein controls histone gene expression 17.30‐17.45 Break 90 | P á g i n a
17.45‐18.45 Invited Lecture Role of presynaptic glutamate receptors in short‐term synaptic plasticity Christophe Mulle Laboratoire Physiologie Cellulaire de la Synapse, Centre National de la Recherche Scientifique Unité Mixte de Recherche 5091, Bordeaux Neuroscience Institute, University of Bordeaux 2, Bordeaux, France (Chair: Ana Luísa Carvalho) 20.15 Dinner at Restaurante Fininho 91 | P á g i n a
17th December 2008 Session V‐ Health, Toxicity & Disease Chairpersons: Eugénia Carvalho | Claúdia Pereira 9.30: Ana Paula Sousa | Evaluation of chromatin status and of distinct functional subpopulations in human sperm 9.50: Lígia Gomes | Exploring the relationship between mitochondrial morphology and autophagy 10.10: Teresa L. Serafim | Berberine as a mitochondrially‐active anti‐tumor agent 10.30: Ana Burgeiro | Edelfosine: A promising drug against metastatic melanoma 10.50‐11.20: Coffee Break Session VI – Structures & Systems Chairpersons: Armindo Salvador | John Jones 11.20: Elsa S. Henriques (Ciência 2007)| Structure, (un)folding and homology: A computational approach 11.40: Pedro Branco | Quantitative profiling of covalent modifications of hemoglobin 12.00: Carlos J. V. Simões | New challenges from old problems: Transthyretin amyloid as a model target for the modulation of protein‐protein interactions 12.20: Cristina Barosa | Quantifying the contribution of proteolytic and metabolic sources of glutamine to the hepatic glutamine pool 12.40: Inês Miranda‐Santos | Development of a methodology to profile the mitotic‐cycle‐dependent metabolism 13.00‐14.30: Lunch Session VII – Disease & Neurodegeneration Chairpersons: Ana Cristina Rego | Paulo Oliveira 14.30: Susana Rosa | Deficient high glucose‐induced GLUT‐1 downregulation leads to increased intracellular glucose and oxidative stress in osteoarthritic chondrocytes 14.50: Ricardo J. Soares | Involvement of microRNA in the regulation of skeletal muscle atrophy 15.10: Joana M. Gaspar | The levels of synaptic protein in hippocampal nerve terminals are affected by Diabetes 15.30: João Pedro Lopes | Neurodegeneration in Alzheimer’s disease and prion‐related encephalopaties: The role of cyclin‐dependent kinase 5 and cell cycle regulators 15.50: Ana Clara Cristóvão | The role of NADPH oxidase‐derived reactive oxygen species in paraquat‐mediated dopaminergic cell death 16.10‐16.40‐ Coffee Break Session VIII – Neurodegeneration & Behaviour Chairpersons: Attila Köfalvi | Paula Moreira 16.40: Helena S. Domingues | Differential roles of th1 and th17 CD4+ T cell subsets in the pathogenesis of EAE 17.00: Mário Laço | Uncovering the cellular and biological role of normal ataxin‐3 17.20: Manuella Kaster | Caffeine and adenosine A2A receptor blockade prevents alterations of neuroplasticity and behavioural profile in mice subject to chronic unpredictable stress 17.40: Eduardo Dias‐Ferreira | Chronic stress causes cortiocostriatal reorganization and affects decision‐making 18.00‐18.10: Break 18.10‐19.10: Invited Lecture‐ Hartmut Wekerle (Chair: João Malva) 19.10 Closing Remarks ‐ Euclides Pires [CNC Vice‐President] 92 | P á g i n a
After‐Meeting (Informal Presentations of Second Year BEB students) FMUC, BEB Room 18th December 2008 9.00 Sueli Marques | Epigenetics in Alzheimer’s disease‐related Neurodegeneration (Local supervisor ‐ Claúdia Pereira) 9.20 Susana Louros | The role of transmembrane AMPA receptor regulatory proteins (TARPS) in synapse remodeling (Local supervisor ‐ Ana Luísa Carvalho) 9.40 João Noutel | Synapse remodeling in a mouse model for an autism spectrum disorder (Local supervisor ‐ Ana Luísa Carvalho) 10.00 Gil Cunha | Brain‐reading the neural bases of visual impairment and rehabilitation of amblyopia (Local supervisor ‐ Miguel Castelo‐Branco) 10.20 Nélio Gonçalves | Gene transfer approach for the study of Adenosine A2A receptors role in Machado‐Joseph disease (Local supervisor ‐ Luís Almeida/Rodrigo Cunha) 10.40 Manuel António Barroso | The immune response to mycobacteria of distinct virulence (Local supervisor ‐ Milton Costa) 11. 00 Break 11.20 Lígia Silva | Silencing human breast cancer (Local supervisor ‐ João Nuno Moreira/Sérgio Simões) 11.40 Sara Figueiredo | Innovative paramagnetic liposomes for the visualization of drug‐delivery/release processes by Magnetic Resonance Imaging (Local supervisor ‐ Carlos Geraldes/João Nuno Moreira) 12.00 Filipe Leal | Regulation of the formation of microtubule organizing structures (Local supervisor ‐ Paula Veríssimo) 12.20 Joana Marinho | Viriato, a novel gene that regulates cell survival and differentiation in the early Drosophila embryo (Local supervisor ‐ Paulo Pereira/Paula Veríssimo) 12.40 Ana Azevedo | Regeneration in zebrafish caudal fin: Looking for new players (Local supervisor ‐ Carlos Duarte) 13.00 Sofia Cabral | Molecular and cellular mechanisms controlling collective cell migration and invasive behaviour during developmental (Local supervisor ‐ Carlos Duarte) 93 | P á g i n a