pengukuran

LAMPIRAN I
PERHITUNGAN UJI HOMOGENITAS DAN RATA-RATA DATA
SANGAN DARI AREA BAWAH KURVA (AUC)
f5ERHITUNGAN U J I HOHOGENITAS D A N RATA-RATA
( AREA DI BACJAH EURVA )
:
NU.
,:A
):=A
:
,:H
:
:
964.57
1014.5
914.22
1116.7
1088.4
DATA HERPASANGAN
x2b
:
:
D =
>:H-;:A
D2
................................................................
1 ! 1415.0 2002451.12
2 ! 1331.0 1771629.94
3 : 1556.4 2422435.12
4 : 1218.7 1485267.71
5 : 1242.2 1545263.07
:
:
930409.96 : -450.55)
1029370.7 : -316.44
835798.29 : -642.19
1247191.0 ! -101.93
1184804.3 ! -153.79
................................................................
T O T A L ! 6763.5 9225046.98
5098.6 5227574.1 : -1664.8
................................................................
5
r,
:
5
5
PIEAN
S1)
:
:
1352.7
137.84
I
I
! 1019.7
! . 84.181
1
:
202952.
100138.
412417.
10371.4
23552.5
749552.
-7-7
,.,\L.
97
220.900
..................................................................
PROSEDUR P E N G U J I A N HONOGENITAS ( U J I DlJA V A R I n N S )
................................................
PROSEUUK P E N G U J I A N :
1. H o :
S2A = SzH;
A r t i n y a , kedrra h a s i l p e n g u k u r a n ~ n e m h e r i k a nv a r l a r l s
yang t i d a k b e r b e d a s e e a r a s i g n i f i k a n .
ti:
S Z A # S'H;
h r t i n y a , kedua h a s i l p r n g u h u r a n memberikan v a r i a n s
yang b e r b e d a s e c a r a s i g n i f i k a n .
2. Fo =
varians terbesar
------------------
3. T b r n f s i g n i f i k a n s i = C1.10
dbl =
4
db2 =
1
,
4.
137.845823
= -----------
var-ians t e r k r c i l
84.1919045 =
,
F tabel =
BERPA-
6.19
I:e.-i.mpulan:
k a r e n a F o b s e r v a s i < F t a b e l , maka Ho d i t r r i m a dan
I-la d i t o l a k . J a d i l : e d ~ ~ ha a s i l p e n g u k u r a n memberli.:an
v a r i a n s yang t i d a k b e r b e d a s e c a r a s l g n i f i l , e n .
-
LANJUTAN
PKOSEDUR PENGUJIAN:
-------------------
I MAI.:SIMUM
1. t o : uD = 0:.
tidal: add perbrdaan r a t a - r a t e a n t a r a
p e r l a k u a n A d e n g a n p e r l a k u a n H.
tia : LID # 0; a d a p e r b e d a a n r a t a - r a t a a n t a r a
perlakuan A dengan p e r l a k u a n H .
2. u j i - t , d i m a n a d b . = n
t ( . 0 5 / 2 ) = 2.776
-
1 =
4
3. M e n c a r i t o b s e r v a s i ( t o ) :
......................
3.
Kesimpulan :
Karena
/ t abcervasi / =
3.370 > t( . 0 5 / 2 )
ma&.a Ho d i t o l a k d a n Ha d i t e r i m a .
J a d i p a d a t a r a f c i g n i f i k a n s i 5% d i s i m p u l k a n bahwa a d n
perbedaan yang s i g n i f i k a n a n t a r a kedua p e r l a k u a n .
LAMPIRAN 11
PERHITUMGAN UJI HOMOGENITAS DAN RATA-RATA DATA BERPASANGAN DARI.WAKTU OBAT MENCAPAI KONSENTRASI MAKSIHUM
DALAM DARAH ( T m a k s )
FERHITUNGAN U J I HOMOGENITAS DAN RATA-RATA DATA BEFiPASANG61.I
( WAETU WENCAPCLI I:ONSENTRASI HAKSIMUPI )
................................................................
NO.
:
A
I
):=A
:
xB
:
91.050
90.61
90.37
90.316
92.596
:
:
x'b
D =
>:B-):A
D"
................................................................
:
:
68.581
75.477
54.055
68.055
b4.273
505.855
228.989
592.389
495.529
802.225
TOTGL: 340.44 23266.2821
: 454.94 41398.431 : 114.498
................................................................
rt
:
5
5.
................................................................
2723.99
:
:
:
4703.47700
5696.86810
4103.2t081
4631.61915
4131.05709
:
:
:
8290.2563
8210.1721
8166.7369
8157.0701
8574.1958
:
:
:
:
22.469
15.1324
26.3153
22.2505
28.3235
1
2
3
4
5
:
MEAN
SD
:
:
69.089
4.5274
------
:
-
c
I
:
90.988
0.9444
..................................................................
PROSEDUR PENGUJ IAN :
-------------------
:
22.8997
5.1:1495:.
- --
-
- .-.
1. Ho : mA = me,
t i d a k . e d a perbedaan r a t a - r a t a a n t a r a
p e r l a k u a n A dengan p e r l a k u a n B.
Ha : mA # mu, ada p e r b e d a a n r a t a - r a t s a n t a r a
perl a k u a n A dengan p e r l a k u a n B.
2. u j i - t , d i m a n a d b l = dbZ = n-1 =
t ( .05/2)=
2.776
4
3. t i e n c a r i t o b s e r v a s i ( t o ) :
A :
BASIS ~t~/a
----------
===----------
B : BASIS a/m
=============
- = --------c >:
X
n
= 90.90386
n =
.-
5
.-
--.
LANJUTAN
/
/
(
SzA/nA
+ SzR/nH)
V
wl. t l + w2. t 2
'
Eesimpulan :
Karena / t o ' /
< d a r i t i t i k k r i t i s maka Ho d i t e r i m a dan
Ha d i t o l a k . J a d i t i d a k a d d p e r b e d a a n y a n g s i g n i f i k a n
a n t a r a Cedua p e r l a k u a n .
--
.
-
PROSEDUK
i
.
.
..-
.
-
PENGUJIAN:
-------------------
,
/
.
1. Ho : LID = 0:. t l d a k add p e r b e d a a n r a t a - r a t a a n t a r a
p e r l a k u a n A dengan p e r l a k u a n R.
Ha : uD # 0; ada p e r b e d a a n r a t a - r a t a a n t a r a
perl a k u a n A dengan p e r l a k u a n H.
= n
2.
u j i - t , dimana db.
t ( . 0 5 / 2 ) = 2.776
3.
Mencar1 t r b s e r v a s l
.I..
......................
-
1 =
4
(to):
I..:osimpulan :
karena
/ t observael / =
10.14 :; t ( .05/2j
maka No d i t o l a k dan Ha d i t e r i m a .
J a d i yada t a r d f s i g n i f i b . a n s i 5% d i s i m p u l k a n bahwa add
perbenaan yang s i g n i f i k a n a n t a r a Cedua p e r l a k u a n .
I
LAMPIRAN I11
PERHITUNGAN U J I IiOHOGENITAS DAN RATA-RATA DATA BERPA-SANGAN DARI KADAR OBAT MAKSIMUM DALAM DARAH
PERHITUNGAN U J I HOMOGENITAS DAN HAT&-RAT& DATA HERPASANGGN
( KONSENTRASI MAP.SIMUfl )
................................................................
NO.
n
:
wA
:
:
5
:
,:B
- .
5
w
A
'
x"b
-
8.4067
: 5.6751
1.6757
: 0.8143
................................................................
NEAN
SD
:
:
D"
5
I
:
:
:
D =
,:B-xA
-2.5316
2 -30394
PROSEDUR PENFUJIAN HOMOGENITAS ( V J I DUA VARIANS)
PROSEDUR PENGUJIAN:
I . Ha: SxA = S28:
A r t i n y a , kedua h a s i l p e n q u k u r a n memberikan v a r i a n s
yang t i d a k b e r b e d a s r c a r a s i g n i f i k e n .
Ha:
S'G # S"H;
A r t i n y a , kedua t i a s i l penqul.uran memherikan v a r i a n s
yanq b e r b e d a s e c a r a s i g n i f i l , + n .
2. Fo =
varians terbesar
-----------------varians terkecil
7 . Taraf
dbl
=
.
s l g n ~ f i k a n s i=
4
dt-2 =
1..1757':1756
=
<1.814;62':lC.
'
-----------
=
0.10
4
.
F tzbel =
6.39
4. Kesimpu 1 an :
k:arena F u b s e r v a s i < F t a t j r l
tla d i t o l a l : ,
J a d i kedua h a s i l
ma1 a I l o d l t e r i n a darl
pcngul:urarx member-iban
v a r i a n s yang t i d a b h e r b e d a s e c i r a s i g n i f i l : . a n .
-
LANJUTAN
PROSEDUR PEP4GUJ IAN:
-------------------
I MAbSIMUM
1. Ho : uD = 0:. t l d a k add perbedaan r a t a - r a t a a n t a r a
perlakuan A dengan perlakuan R .
tin : LID # 0: ada perbedaan
rata-rata
Iakuan A denqan p e r l a k u a n B .
2 . u j i - t , dimana d b . = n
t(.05/2)= 2.776
-
1 =
antara
per-
4
3 . Mencari t o b s e r v a s i (to):
3.
Kesimpulan :
k'.arena / t o h s e r v a s i / =
2.457 C t ( . 0 5 / 2 )
maka H u d i t e r i m a dan H a d i t o l a k .
J a d i pada t a r a f s i g n i f i k a n s i 5% d i s i m p u l k a n bahwa t i d a l
ada perbedaan yang s i g n i f i k a n a n t a r a kedua p e r l a k c ~ a n .
!
LAMP1RAN IV
DISTRIBUSI t PADA BEBERAPA LEVEL PROBABILITAS
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v",,.:,.r<:.
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L
LAMPIRAN V
DISTRIBUSI F PADA BEBERAPA LEVEL PROBABILITAS
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4.(8
LAHPIRAN V I
SURAT PERNYATAAN P E R S E T U J U A N D A R I T I A P SUKARELAVAN
Svyo
yang
AL\W
:
ii~ura
t e n ~ a n di
bcrtondo
habrh
:
ini
T O B I ~ ~
Umur
LIYAS
I.IAPltOXBN,
yurrt:
Nrp
:'
2443089018
Alomut
:
jl.
soya
ra
yenc
I.dupun
vduiah
1.
yand
Mcrrjeluni
pclncrikxr.bn
d&r.ch u n t u k
bioyo
.
cu-
I
.
d i julunl
:
klilliz
1 ~ 1 c n a r 1 k s n k e ~ e h u t u r i zrcy;
10 ml
tcta
jrlur~l.
p e ~ i c l l L I r ~ r rycire:
~ c b u ~ n t lr r i k u t
t i ( l c . 1 ~ di11,rap-
i , l ~ o s ~ - . i u r;*t a u
i l i u r ~ nvyh
proacdur
kc3c:nputun u n t u k m y -
~ ~ r n11;p i ; - i n s
efeh
rnuneki~l t l ; r ~ b u l d u n
pcnclitluu
:
Surabayo
p e n j c l a ~ v n dsn
I~ngunaun I;oproxcn,
lion
10a
Dinoyo
rncndrpatkotr
olch
di1uhukr.n
doktci
urltuk
i r ~ e n ~ r r c b ii l. . l r r - k i 1 . a
gun
diperl!inr
d i t r n e ~ u n e ole)
olch
d l
l:.horotorium
pencliti-
p ~ - ~ -
dun
LANJUTAN
I
-
-
2.
liowoncoro, rueliputi
noh
dideritu,
hioaoon
3.
rorknn,
merokok
sebclum
4.
rikayut
Puaae- - semulom
.
dek
Dotong
u1c1.ci
mcnjclrne
uioupun
tempet
tuknn
woktunyo
selamv
waktu
penyokit
ysne
tert~udopohot,
kc-
wsktu
--
minu~ri obot
pcnellti~n dan tllain
satu minegu
dun sort pennlitlan berlungnung.
penelition
bcruda
tclrh
diten-
temput
pcnclitisn
5. Dlambll sun111el d*z.vh aebunyuk
7.0 ml
podo
wsktu
dun
yang
dl
terval
penelltiun.
0, 15.
30,
45,
60,
ini
auyn
bunt
30,
in-
120,
150,
180, 240 mcnit.
Dernlkinn
keaodvron
don
-.
pcr-
. loirl-lnin.
dan
penelltien
ke
riwnyut
pernyotran
tunpv
puksobn
plhuk-pihrk
denean penuh
luirr.
,-
_I
LANJUTAN
Suya
yang
bertondo
:
HF17-d. G U T W T o
Umur
:
rl S h n
: S.-
bodan
aedio
~nenjodi a u k ~ r t l r ~ a d
n ~ l o ~ pn e n e l l t i o n
LIYAS
BkFROXEN,
yong
I
T
:
i i / ~
d e n g ~ n s e a u n g ~ u h n y a , bstrda
Kcnyutnkun
ini
kg
1
01@0Y0
:
Alotnot
bnhnh
di
Hntss
Bernt
j
tandon
tloiriu
:
H
Nrp
:
244309901 8
Alumat
:
jl.
dilukukun
oleh
i
/
sryu bcrPLZNGARUH
1
i
1
:
&
Dinoyo
Surrbaya
100
I
Pernyotoon
auyo
peraetujuvn
mendupotkon
nanyrken
hol-ha1
kcgununrl
Knproxen,
hun
ra
penelition
addlab
ybng
saya
mengerti
sc,r~ping yrng
efcL
den
sctel~~h
In--
tentang
t i d a k dihorep-
pros-dur a t n u t z t e
arya
okurr
proscdur
buut
lrcaelnputrn urltuk
drrr
belum
y@nl; n u n ~ k i l l t i n i b u l
1,dbpun
1.
penjelanon
ysng
su:iu
i l l i
efi-
jalani.
! , c ~ i r l i t i p n yci.6
aka12
d ij u l u n i
actcg~l beri~ut :
i . . c ~ ~ j ~ l u npic ~ n c r i k a u b f l i . l i r l i a
,rlemerikau
10 m l
kcaellvLuii
d c ~ . c t i untu;.
SI.J,
dblr
di,,rr,lkau
olch
dokLcr
uritul.
~ i i r n ~ u i o1t ~k i r u - 1 . i r
cli
1. bur . t o r l u m
u
d.m
-
LANJUTAN
-bioyr
2.
ditenggung
Wawoncaro,
noh
3.
Puosn
duk
meliputi
dideritu,
biosoan
olrli
semnlorn
merokok
don
Dotang
ke
tuknn
penyakit
alergl
perke-
lain-lnin.
moupun
tempvt
ysng
terhedop obet,
~ncr~jelongwrktu
sebelum penelition
4.
riwayot
riwaynt
Inakun,
peneliti.
minunr
obat
penelitinn dun tilnin
sotu rnincp,u
don soat penalition berlungnunfi.
penelition
noktt~nyo dan
tcleh
ditcn-
di
tempat
penelitiarl
5. Diombll salnpel dkrvh sebnnyok
2,0 ml
pado
aeloma
woktu
terval
180,
wnktu
240
Dcmikion
kesodoran
don
berudo
yony
penelltian.
15,
0,
70,
45,
60,
90.
in-
120.
menit.
pernyetron
tonpn
ini
pokseun
sayo
bunt
pihnk-pihsk
dengon penuh
lrirr.
I-
Surrboyr,
Hormrt
Ijrr.
UMI
150,
ATIIIJAII,
KC
nay*,
LANJUTAN
--
Svya
-
-
yang
bcrtvnda
--- -
--
--
tan,:on
di
Iinlrla
: lWATAi-7 SUKAHADI
Umur
: 2B W-n
Derat
Alamet
:
3L.MOJO .I /
Menyatukan
aedia
derlgsn
menjudi
PENAMUAIIAN
;I ulna
ALUNIIiIUPI
B
:
Pernyatnan
auya
hol-ha1
kegunrorl
I<rproxeri,
re
hdapun
adalah
1.
olch
dcrr
beluro
efeh
s::v
Ler-
i'EI;GIJ<C!i
~ s y o lnengcrt.1
jang
don
says
ten:&n&
atou t ~ t sck-
~olcni.
y n r ~ g ahur.
d i Ju1ur.i
:
pctserik~unn k l i l ~ l s 01th
IIICIOCI'~~JY
keaeLa~L,~i ~ r r y v
untuX
set cluh
t i d h ; ~d i h o r u p -
p1.08-dur
petlclitirrl
tarlkut
bust
keac:nputcn u n t u k - s r -
svmpiriy
&Lon
proscdul'
duroh
.
:
aoya
i l t i
Mcnjalunl
10 m l
- -
ysni:
yung
aebagal
:
It
y u r ~ roungkir~
~
ti:rrlul
penelition
SURAQAY4
f
dilukukvn
penjelvaan
nanyoksn
kcn
~
d~larn !)cnelitiun
persetujurn
mandupotkon
-
HIU~~OIUITJATSRliBDfiP UIOXVAILALI-
yurri;
I T
Ini
beach
n e a u n g g u h n y ~ , balria
aukureluwan
NAPFiGXEN,
LIZ'AS
--
k9.
52-
:
badon
-
.
. -.-
\lull
doktcr
untuk
a c n & a t r D i l L11.u-1iir.u
dipcrik~u dl
l ~ b o r u t o r i u t nd r n
,
LANJUTAN
. -.
bioyo
2.
ditonggung
Wowoncara,
noh
biosaan
riwvyot
riwuynt
moknn,
-
ole11 peneliti.
meliputi
dlderitu,
-
don
penyokit
olere1
yang
per-
tcrh~dopobut,
ke-
10111-lain.
3. P u a ~ o semnlam tr~enjelong woktu penelltian den tidok
I
merokok
sebelum
penelition
4. Datong ke
tuknn
rnoupun minual
tempot
woktunge
aelun~o woktu
,
5.
Dlombll
100,
240
Dernikion
kesaderan don
loin
penelition
don
berodm
yon3
dl
teloh
tempat
UklI
diten-
penelltian
penelition.
0,
15,
sebur~ynk 7.0 1111 podo
In-
,
45,
150,
ini
suya
60.
90.
120,
menit.
pernyutuan
tanpa
paksaon
bunt
pihok-pihak
Nsr~~etahui
Dru.
setu minegu
dan seat penalition herlongnung.
somgel d u r u h
terval woktu
obot
ATIIIJAII,
14:;
LR. Il<'riAK
dendon perlull
loin.
,.
LANJUTAN
I
Soya
yong
bertonda
tsn~an di
I(OU0
: Hcndrnkus A s k t ~
i
Umur
:
z z th
I
Berot
:
So k y
,
:
badou
Alarnat
Menyotakon
'
aedio
lnenjedi
Ph'1;AFBAIlkN
LITAS
Dsooyo
"7
dengun
seaun&guhnyn,
auksrelvwsn
ALUMIIiIUH
NAPROXEN,
Namo
:
R
N ~ P
:
2443089018
Alumat
:
jl.
T
svya
nanyoksn
ysng
kegurioar~ Noproxen,
kon
rs
yrng
Aduy)un
vdolah
1.
yvng
oleh
asyo
i l l 1
soya
lncneerti
sr:an
says
l
i
Lcr1k.t
:
t
terrtorlg
t i d u k dlhurupcu-
jrlani.
y u ~ l a~l [ r r ~
I
lnernerlkso
k c s e l i r ~ t s r l any2
untuk
sctcluh
p r o ~ e d u rs t u u t i t s
don
p c ~ n e r i k ~ r o nk l i ~ ~ i os l c h
drrsh
buat
d s r ~ keacrnpatan u n t u k 111r-
Hcnjplvni
10 m l
?EI:GILP.UE
:
~ u m p l n g yang
efeh
pronndur.
aebngsi
pcnelltion
Suruboya
belurn
r n u n e k i ~ ~t i n L u l
penelition
soya ber-
I*
108
pcnjclaaan
hal-hai
bohwa
:
A
peraetujuvn
mnndopatkun
in1
TERIihDhP BIOLVAILAbI-
dilokulcvn
Dlnoyo
Pernyotron
dololn
i!IUhOi(SIDA
yong
I
bahrh
dokter
di Jul&rrL
~ntt~ii
d ~ n ilirn;&.r.bil kiru-ki1.u
diperiksu
dl
l + t ~ o r r t o r i u r ndun
LANJUTAN
bioyo
2.
Wowoncoro,
nnh
i
i
ditonggung
oleh. peneliti.
nleliputi
riwayot
diderito, riwoyot
hiosoan
muknn,
don
penyokit
yone
per-
o l e r ~ i terhodop obot,
kc-
loi11-1f~in.
3. Pumso aemulorn l~~enjelongwoktu penelition dun tidak
merokok
innupun
sebelum penelition
4. Dotong
ternput
ke
tuknn
woktunyo
selomu
woktu
180,
Demikion
loin
pcnelitiun ynng
berudo
di
teloll
tempot
deroh
penelition
0,
15,
scbunyok 2.0 a11 pado
30,
45,
60,
pernyotoan
tonpo
ini
paksarn
soya
bunt
pihok-pihek
1.iengetohui :
L.
UI4I
diten-
90.
In-
120,
150,
menit.
kesodaron dan
Drr.
satu minegu
penelltion.
wnktu
240
obat
don shot penslition berlongaung.
don
5. Diombll aompel
terval
minurn
-
loin.
,-
P
'**
ATIIIJAIi,
Tembimbing
dengon penuh
I
MS
DR. I K Y R L
pcnonggun&
S&kWq
jowob medl3
LANJUTAN
Menyetoken
acdin
menjrdi
PEKAbIBAIiAN
LITAS
d e n g ~ n xenunijgulsny~, brt~wa nryv L r r sukvl.eluuan
A L U M I ~ ; I U ~ HIDIIOKSIGA
NAPROWN,
ynng
N ~ P
:' 2 4 4 3 0 0 9 0 10
Alnmat
:
hnl-ha1
ltegunrnn
Brproxen,
efeh
rnungkin
ti;nbul
ken
rs
yeng
ndalah
1.
yany
p e n c l i t i o r ~ yrng
hdopun
aernpins
untuk
~nengerti
ysng
IIIC-
tcnterig
t i d e k dihnr.apcu-
Jalani.
yci.d
alcnr.
dijul~lli
:
pelnerikaoon
dersh
scteleh
pr.o~cdurstvu t r t a
says
klirtis
181emeriksa k c a c h a t u r ~ s n y s
10 r n l
suya
dun
buat
k c s e : n p u t ~ nu n t u k
penrlitiprr
~ e b e e n i barikut
:
aoya
dun
brlurn
rhun
proscdur
Ncnjolvni
ini
penjclaaon
nunyoksn
oleh
Surubnyn
108
pcrsetujuvn
mendapotken
PENCARUIi
TERHADAP 5IOhVAILAbI-
clilnkukon
Dinoyo
jl.
Pernyrtuon
aryo
drlu~n penslition
don
dipcrikau
oleh
dokter
untuk
~ s c f i ~ ~ ~Is. .bi rlul- l ~ i ~ . o
di
1 r . h o r u t o r i u r a dun
LANJUTAN
-
bioyo
2.
ditenggung
Wowencoro,
noh
3.
Puoso
dok
riwoyot
moknn,
merokok
den
penelition
aelomo woktu
i
5.
vlergi
Diombll
Demikion
kesodaron don
yrrrg
pcr-
tcrhadop obat,
ke-
penelitinn don ti-
obat
lain
~ v t urninggu
don avot penalition herlungnung.
don
berado
di
tempat
penelition
penelitian.
omp pel
terval woktu
- --
loin-lain.
Inoupun atinurn
t u k ~ n woktunyo
--
-
penyokit
semoloin rnenjelone woktu
aebalum
:
- -.-.
olel: peneliti.
nreliputi riwayrt
diderite,
hiosoon
;
-.
.-
.
doroh
0.
15.
pernyotnan
tunpo
scbonyok 2.0 rnl
30,
in1
puksabn
45,
60,
auyo
bunt
pihok-pihak
pndo
90.
in-
120, 1 5 0 ,
dengan perruh
lain.
,-
Dru.
UMI
ATkIIJAH,
145
liR
. IlLiiAfi
penunzgune
SETIXOUDI
juwob
media
I
LAHPIRAN V I I
H A S I L PEHERIKSAAN LABORATARIUH D A R I TIAP SUKARELAWAN
.
I
..--
IABORATORIUM M W I S '
. ,
MOJOPAIIITU
~4s"
/
;
I
it
2
---.
----
'
APJ
-.-----
i
.
: --A.
tgl.u(cul
:
a.
.............................................
: ................... .......................
:
..............................................
.a
:: ............................................
ml
mg%
m p
U
Mu/ml
..:..............................................
.
: ............................................ p%
..........................................p%
:
;
..
.'
.......!2.:....................
/0.
.............................................
.,
.............................................
8
'
,............................................
.
:
:
,-..
! i
.................. :.........................
U/I
U/I
gr%
gr%
U/I
*.
.a.
.,*.
NORMAL
>13d
( < 0.50 ma%
( < l.Wmg%
(
( 0.5,Ou
6-8p%
0.3 - mrsS
,"9
)
(
1
)
( Prla 11 50 U/I
1
( Wanlu7
)
-
: 0.6
Pria
Jurnlah Urine
.
Clcnrancc/menit
:
rngx
-jam
.....
Wantla: 0.5
- 32 U/I
I
)
: -
Uric A c i d
:
1.5 mg %
- 1.3 mg%
-ml
- mg %
--
m
. . . . . .
- zo m g % )
( 20 - 10 mg 7; )
:2.5 - 7.0 m
(:
( lo
m.%
Uriurn Darah
-
ml /mcnit 1 1,75/rnz / S A
12.
4.
U. N.
,
wanita < 31 ~ /) l ':
W a d u < 31 U/l ) . /
I
1
NORMAL
J.
.
a < 37 U/I
( o p t 3 7 ' ~P r h < 40 U/1
( 2-3@.
( 4.5@
'
"
HASlL
:
i
i
FAAL - GINJAL
Crcatioioc
I
1
:
I i U s Ab.
Crcatinine
I
.I
)
( 15 69 mU/ml
(
0.9
( o p t 3743 m
-
--
)
t1DS A g
<mum
.......19...........
.-.I,.-,
- - - . - -
CIY-
HASIL
1
:.
. ...->..-- . :.y
,'l.pnua-
HATI
FAAL
Gross
Hcyman v/d bcrgh dlrccl
ec,...
(,oul,
1
Xhymol Tur bldiry Test
Alkali Phasphatuc
.
&rum Protein
Gamma Globulin
t 1S. G. 0. T.
Y S. G. P. T
.
j %rum Globulin
: krumrUbumin
Gamma 'G.T.
;.:
.
2
:
-
No. ~ b m t o r i ~ n: .
~ottcrpcnlirim
.-- ...
S u n b a ...................
~
Z.: ...:.
:.:
1
NO. 1. S U & ~
-eCndc.iu
I
Pria
W a n i i a : 1.5 - 6.0 mp%
- -
... ..-L-
LANJUTAN
-
r.
...
-......
-.
_.......
IABORATORIUM MEDlS
MOJOPAHIT XI
Jab Moiopohil No.
,
No. -durn
:
.
mkwrpndrim
i
-.-....-- --..-"fix--.----...-.-.-.-...-
,~.-ri-
:
td..C(L..I
:
OUM
3
;
_
( > 13ml
( < 0.50 mg%
lndircc! (total)
(
Gamma Globulin
( 0-5.OU
::
( 15 69 mU/ml
.......................................
aY
.
: .............. 3:
......................
............................................
Scrum Globulin
:
Serum Albumin
:
Gamma G.T.
.............................................
-:&.:-.*.....
.-......-.-..
.......................:....................
)
1
1
1
< 1.00 mp%
:'
i:
w. G. 0 . T.
4.G. P. T.
"
--..-
NORMAL
............................................m l
............................................mg%
............................................. mg%
............................................U
............................................Mulml
!
.: ............................................gr96
: ............................................gr96
Gross
:
Heyman v/d bcrgh dlrm :'
, p y m o l Tur bidity T a t
'
................--
HAT1
HASIL
.
.. ............
---- --....-- i. . . : ". ......
.L
.J
!
. I
FAAL
: , Alkali Phorpharase
; . SCNI~ Proccin
. .
.!:";$
Sumbay..................................... 19
fi?%tP
---_l-c
i
.
..?.., .. ,:
2. lu
~ v npnderiu
r
.
-
.
U/I
( 6-8@
)
( 0.3 0 9 mL9L
)
( opt 3?c m < 37 U/I w m t u c 31 U/I
U/I
( opt 37'~ Prla < 40 U/l Wanlta c 31 U/I )
gr96
gr96
( 2-3@
)
( 4-5( Prla 11-5OU/I
)
)
-
u/I
-
j
( WanIu 7 32 U/I
.............................................
: ............................................
W Ds A g
HUsAb.
1
I
.
I
__ _
1;
,
I
~
..
~
FAAL GINJAL
.
I
...
....
:I
-I
I
HASIL
'
I
<Serum
Creariaine
'
/, 0
:
Uriae Creatiaiae
:
1
i
Jumlah Urine
: --jam
Clcnraoce/meoit
:
I
I
I
! ' .
NORIMAL
Crcatinine
I
1
.....
....
/El.
U. N.
mg
.- 8
U ~ i u r nDarah
:
Uric Acid
:
m
Wanirn: 0.5 :0.6
Pria
1,s mg%
1.3 m:%
X
-m l
ml [mcait! 1.731 m 2 / S A
--
!WX
(10-20 m g x )
mg %
- 40 rn;::)
Pria
: 2.5 - 7.0 m p X
Wxnita: 1.5 - 6.0 mg%
ms;:
'
(20
1
LANJUTAN
I-.
,
!
.
I
WORATORIUM MEDIS
MOJOPAIIIT11
I&" Mojo&ic No. 2. s",.bq.
N=mapc?dcda
:
No. bbancorium :
Dakcer pcn%rim
:
/$. #c.&;~
........l.... 3 .
. . . ....... .. ....
.
19
.-............
S u n b a y..........................................
.
rll.pcnerimun :
:..-iL ..--.. . .
....
..
.
/h.r.
-.
I
............................................
: ............................................
Gross
:
"
NORMAL
( > 1.3 ml
( < 0.50 mg%
( < 1.00 mg%
( 0 5.0 U
ml
--
-
'
)
-
)
)
( 0.3
)
-
0.9 ng%
( opt 374: Ptia
< 37 U/I W m l u c 3 1 U/l )
opt 37% Prla < 40 U/l Wanlu c 3 1 U/I )
( 2-3gr%
)
( 4-5g%
)
( Prla 11 . 5 0 U/I
)
!
I
i
GIKJAL
NORMAL
HASIL
Prin
L'
m~.:;
Uriac Crcntioinc
:
Jumlnh U r i n e
:
Clcsrnnce[ rncnit
:
B. U. N.
.
Urium Darah
:
Uric Ac~d
. --
I!
:0.6-1.5mg%
agn;rn:~,j-~.lm:%
','
_ ml
rno
=,o
--
.ism
-
rnl !mcnir 1 l , i ~ / m ~ / S A
4.
.
ma:;
-
( 1 0 - 2 U m:%)
me 7:
mp::
!
)
( 6.8prs6
(
i
)
( 15 69 mU/ml
Crcarininc
.
I
1
---FAAL
/Strum Crcarlninc
;
.......................... .........................................
Heyman v/d bergh dlrcci
me%
lndlrcct (total)
............................................. ms%
n l y m o l Tur bidity Test
: ............................................ U
Nknli Phosphziue
: ............................................ Mu/ml
Scmln Prolcin
............................................. fi
Gainma Globulin
............................................. fi
4.%. ..........-. ......
,
G. 0 . T.
: .................
U/I
do .
Ids. G. P. T.
.............................................
ufl
Scrum Clobulin
............................................. fi
,
.
Serum Albumin
,............................................. pr%
Gamma C.T.
............................................. U/I
-.
-
:
CIum
HATI
FAAL
HASIL
I
._
......................
1d.Yl-i
(20
- 40
me::)
: 2.5 - i,G m p X
Wanira : 1.5 6.0 m p %
Pr13
-
.
LANJUTAM
~
.
~
~
-
.
/.IABOIWTORIUM MEDIS
h r o J o P n r r r r 11
j
I
I
,
j
!
j.
~
:
/Tn. A&.
"..".......
No. bbancarium ':
k k t n pcndrim
.......--.-"-..."-"
?.$: -...-......
1
I -
:
GUM
r
.
"
:
............................................
............................................
: ...........................................
: ............................................
( > 1.3 ml
)
( < 0.50 mg%
)
Indirect (total)
lllymol Tur bidity Tcst
Nkali P l ~ o r p h a l u e
m
U
Mu/ml
( c 1.00 mg%
( 0-5,Ou
)
( 15 69 mU/ml
)
( 6-8@
1
.
.........................................
: ............................................ gr%
: ............................................ w%
43.
...........................................
U/I
: .................
.................... U/L
:
...........................................
: ..................... :.....................
gr%
:
U/I
-
............................................
ii
!
iI
)
1
)
( 0.3 0.9 d
( o p t 37% Prla < 37 U/I Wanlta < 31 U/l )
( o p t 3 7 ' ~Prla < 40 U/l Wanlu c 31 U/I )
:
(
( 4.58%
( Prla 11 -5OU/I
-
!
I
1
)
2-3pr%
[
i
m~
mg%
1
[
i
)
j
( Wanlu 7 3 2 U/I
IILIs Ag.
IIlls Ab.
i
~
NORMAL
H A S I L
I
.
t
~ross
:
lliyman v/d bcrgh dlrccr :
S C N Protcin
~
Gamma Globulln
! "S. G. 0 . 1 .
/s. G. P. T.
Scrum Globulin
Serum Albumin
Gamma G.T.
.
HAT1
F A A L
1
-~
-*
:
-.-..-...........-
s
!
...
~- . .
- . -.
.
..
S u n b a p...................... :..................
. . 19
. ,.,. ....... i
.
,&,.
pourirnun
-.,
--. I.
.
,&,.
-1..----;..=I
1
"-..
....-
Jalur Hoiophir No. 1. Sumby
Nmmr pendcnu
.
~
t
i
j
~
.............................................
: ........................... -.-...............
I
i
I
I
i
!
I
1
i
..
.............
-...................
. . .
FAAL
I
i
NORIVAL
Crcarininc
Pria
:
U r i x Crcatioinc
:
J u n l n h Urine
:
Clcaiancr/meoir
:
4.U. N.
7'
L
: 0.6 -
1.5
mgz
-
1.3
m:%
Wani:a: 0.5
mg:;
mf
--
---___)
GINJAL
HASIL
~ S c r u mCrcarinioc
::
rnl
j3m
m l /menit! 1,731 m 2 / S . A
9
:
U r i u m Darah
:
.
Uric Acid
:
-
m;:
-
mg%
mg>i
1:
- 20 rng % )
( 2 0 - 40 mf::)
Pria
:2.5 - 7.0 rn:%
Wanila : 1.5 - 6.0 rng%
.
( 10
LANJUTAN
.~
.
-.-I
W O R A T O R I U M MEDIS
lrrOJOPAHlT n
Moiop3lil No. 1. sunbm
N-a
pcndcriu
:
....Y
: ...
tpl.vkvi
D-klcr pcngirim
cautln
HAT1
FAAL
HASIL
...........................................
: ............................................
:
Hcyman v/d bcrgh dlrcct
Indirect (total)
Thymot Tur bidity Tcst
Alkali Phorphatasc
S C N I Protein
~
Gamma Globulin
- '5. G. 0.
T.
S. G. P. T.
Scrum Globulin
Scruin hlbumin
Gamma G.T.
NORMAL
> 1.3d
( < 0.50 ma%
ml
mg%
(
mg%
( < 1.00 mg%
............................................ U
........................................... Mu/ml
............................................. fl
.............................................
fl
/o.
.............................................
-
:
:
.............................................
/'.j
IllJs Ab.
'/
:
U/r
V/l
( opt 3 7 ' ~Prla < 40 U/l Wanlu < 31 U/I )
( 2-3g%
)
( Waniu7-32U/I
)
mmgo;
j%m
Clc2rnoc:/
:
Uric h o d
)
NORhlhL
:0.6 - 1.S mg%
W a n $ ( = :0,s
-
1 . 3 rn;%
ml
ml \m:ni[
'3.
,
1
)
:
:
- 0.9 mr%
( 4-5896
J u m l ~ hUrine
.-
)
( Pria 11 . 5 0 U/I
.-....-... mg;;
Urium Dnrah
!
1
"/I
. -.... -.
meall
)
srss
rJr;zc Crcntininc
5. U. N.
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)
Pria
v Strum Crcalioinc
1
( 6 - 8 f l
.
1 !,75!m2,'S.i
mz;;
( lo -
rn:;;
(20
m2.L
Pria
-
: 2.5
W ~ n i t n: 1.5
2u rng 9,
40 rng",)
-
7.0 m n f <
- 6.0 mg%
I
)
1
HJ.SIL
/;
"
( o p t 37% Prla < 3 7 U/I Wanlu c 3 1 V/I)
.............................................fl
Crcntininc
"
( 0 5.0 U
( I S 19 mU/ml
( 0.3
.............................................
.............................................
HDs Ag.
.-
,gl. pcncrimvn :
NO. I-abon<orius :
Gross
. ..:...I9...........
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i
LAMP I RAN Vl 11
S E R T I F I K A T ANALISIS
BAHAN BAKU NAPROXEN
G~~Oflff
kaQ@
@ff
B,iiIAMAS CHEdlCAL DlVlSlON
P. 0. BOX F-2430
FREEPORT, BAHAMAS
L/C
NO.
005.201/0131/USANCE
PROUUCT: NAPROXEN PHARMACEUTICAL GRADE
CODE NC: 401033
ANALYSIS NO: 00014872
SPEC RO: 5-100-4
BATCH NO: 2AY152
LOT NO:B2-JA-021
Thix material has been analyzed and has been found to meet all appllcabla
speclflcatlons. Ue have permanent records In our control laboratory
vhlch constltute ObjectlVe evldence to afflrm the above statement.
.'
RESULT
SPECIFICATION
APPEARANCE OF SOLIDS
DESCRIPTION
PASS
WHITE TO OFF UNITE CRYSTALLINE
'
POWDER
ODOR DETERMINATION
ODOR
PASS
ALMOST ODORLESS CRYSTALLINE
POWDER
SOLVBILITY
SOLUDILITY
PASS
PRACTICALLY INSOLUBLE IN WATER
FREELY SOLUBLE IN CHLOROFORM
AIlD ETHANOL
INFRARED ANALYSIS
SCAN
COMPARES TO REF
SAME AS REFEREI!CE STANDARD
SIMILARLY MEASURED
ZI.YSIS
NAP3OXEN UV ASSAY
X REL TO REF
LAMBDA MAX
SCAN OF TIIE SAMPLE IS THE SAME
AS THE REF SIMILARLY MEASURED,
%RELATIVE TO REF IS BETWEEN 97
-AND 103% C.ND LAMDBA HAX IS
BETWEEN 269 AND 273 NU
SPEZIFIC ROTATION
SPECIFIC ROTATION IS BETWEEN
.
63.0 AND 68.5 DECREES
A
VG
NOT HORE THAN 0.5% HAXIHUH
LOSS ON DRYING
% liT LOSS
NOT MORE THAN 0.5% OF ANY ONE
FRS AND NOT HORE THAN 2.0%
TOTAL FRS
-.
'NOT MORE THAN 0.1% RESIDUE
ON IGNITION
NAPROXEN TLC
TOTALFRS
IIlD FRS
RESIDUE 011 IGNITION
RESIDUE
NOT UORE THAN 2OPPH
TANABE SPEC NOT HORE THAN
10 PPH
IIEAVY HETALS
HEAVY HETALS
PAGE
-
1
LANJUTAN
BAHAMAS CHEMICAL DIVISION
P.0.BOX F.2430
FREEPORT. BAHAMAS
PRODUCT: NAPROXEN PHARMACEUTICAL GRADE
CODE NO: 401033
ANALYSIS NO: 00014872
SPEC NO: 5-100-4
BATCH NO: 2AYl52
LOT NO:B2-JA-021
This materlal has been analyzed and has been found to meet all applicable
speciflcatlons. We have permanent records in our control laboratory
vhlch constltute objective eVldenCe to afflrm the above statement.
A. ;YSIS
RESULT
RESIDUAL BASE
RES BASE
(0
SPECIFICATION
NOT MORE THAN 0.01%
.01'.
PARTICLE SIZE
X(25OU
% (75U
NOT LESS THAN 95% IS LESS THAN
250 MICRONS AND NOT LESS THAN
80% IS LESS THAN 7 5 MICRONS
NAPROXEN ASSAY
MEAN
NOT LESS THAN 98.5% ON THE
DRIED BASIS
MELTItiG RANGE
INITIAL TEMP
FINAL TEMP
154.0
156.5
MELTS BETWEEN 152.0 AND 158.0
DEGREES CENTIGRADE WITHIN A
RANGE OF 3 DEGREES
CLARITY OF SOLUTION
CLARITY
PASS
SUBSTANTIALLY CLEAR AND FREE
OF FOREIGN MATTER
-
DATE OF MANUFACTURE (HONTHIYEA
RELEASED BY:
COPIED BY:
I#-
a
I (1 1992
DATE RELEASED:
PAGE
- 2
\f
mawn %?,I
,
,
!
.
i
!
1
X
RECOVERY YANG DIDBPAT DARI FREKUENSI EKSTRAKSI YANG
BERBEDA
Recovery
No. Konsentrasi
(ppm)
B
A
Konsen- Recove- Konsen- Recovetrasi
trasi
ry
ry
>
(P P ~
(%
>
>
(P P ~
(X>
1.
0,5
0,231
62,O
0,46
92,O
2.
1,o
0,63
63,O
0,96
96,O
3.
1,5
0,90
60,O
1,41
94,O
4
2,o
1,33
66,5
1,91
95,5
5.
3,O
1,82
60,7
2,78
92,7
f=62,44
A : sampel
plasma
?=94,04
yang d i e k s t r a k s i s a t u
kali
yang d i e k s t r a k s i t i g a
kali
dengan p r o s e d u r )
B
:
sampel
plasma
(sesuai
LBHPIRAN X
%RECOVERY YANG DIDAPAT DARI WAKTU EKSTRAKSI YANG
BERBEDA
Recovery
No. Konsentrasi
(ppm)
B
A
Konsen- Recove- Konsen- Recovetrasi
trasi
ry
ry
(PP~)
(XI
(P P ~
(%I
>
1.
0,5
0,46
92,O
0,47
94,O
2.
1,o
0,93
96,O
0,95
95,O
3.
1,5
1,41
94,O
1,39
93,O
4
2,o
1,91
95,5
1,88
94,O
5.
3,O
2,78
92,7
2,82
94,O
,
X=62,44
F=94,00
L
Reterangan
A = sampel plasma yang d i e k s t r a k s i t i g a
w a k t u 15 m e n i t
B = sampel plasma yang d i e k s t r a k s i t i g a
w a k t u 15 m e n i t , 10 m e n i t , 5 m e n i t .
kali
dengan
kali
dengan