Relatório de Actividades 2007 - Centro de Química da Madeira

Transcrição

Activity Report 2007
Funchal, March 2008
Centro de Química da Madeira
Activity Report
2007
The research unit is financially supported by:
FCT Research Unit Number: 674
© CQM - Centro de Química da Madeira – University of Madeira – Funchal – Portugal - http://cqm.uma.pt
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Table of Contents
Chapter
Page
1. Summary
Overview
4
Main Achievements
4
Outlook
6
2. Unit identification
8
3. Research team
9
4. Scientific report
Research activities
12
Scientific projects and contracts
13
Organised meetings, conferences and short courses
20
Visiting fellows
21
Stays in other research centres
21
Other activities by team member
21
Awards and other merits
24
Main collaborations
24
5. Indicators
26
6. Publications
Books
28
Thesis
28
Papers
28
Proceedings
31
Abstracts in scientific meetings
31
Science divulgation communications
36
Popular press articles and newspaper interviews
36
7. Funding
37
8. Main supporters
38
9. Annexes
39
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1. Summary
1.1 OVERVIEW
Centro de Química da Madeira (CQM) was officially created in 2004 with the approval of a proposal,
submitted in 2002, to the Fundação para a Ciência e a Tecnologia (FCT) by a group of five (5) Ph. D.
researchers from the Chemistry Department of the University of Madeira (UMa). Its stated mission is
devoted to the development of R&D activities in the field of Chemistry and Biochemistry in Madeira
Island, promoting simultaneously the post-graduation formation, the collaboration with other national
and international research unities, the services to the community and the popularization of science
among youngsters and the society in general. The research centre is organized in two research groups:
Natural Products and Materials group. Currently, our research team is composed by 9 permanent Ph. D.
members (from two Departments: Chemistry and Health Sciences), 2 Ph. D. From other institutions, 4
Post-docs, 8 Ph. D. students, 14 collaborators including several undergraduate and graduate students
and one administrative staff member.
The ongoing research projects represent a total of € 700.000. This sum, along with previous financed
projects, amount more than € 3.3 millions (considering the budget of all partners involved). Research
projects are directed towards applied research with high local impact (evaluation and improvement of
Madeira wine; chemical characterization and pharmaceutical potential of products extracted from
endemic plants) and also directed to most emergent and demanding fields (design and synthesis of
drugs from bioactive natural analogues; gene delivery; molecular modeling; and nanochemistry with
electronic and biomedical applications).
1.2 MAIN ACHIEVEMENTS
This report describes the activities carried out by CQM during the year of 2007, the fourth year covered
by the financial support of FCT. The report reflects the work developed in terms of publications,
preparation of research projects, consolidation or establishment of new collaborations, networking,
recruitment of Ph. D. and Post-doc students, as well as scientific divulgation actions.
During 2007 CQM had 26 research projects of different types, funded by diverse entities (like FCT and
INTERREG IIIB), and mostly headed by CQM researchers (see 4.2 Scientific Projects and Contracts). Two
new FCT projects (DENDRALGENE and FUNCMETAL), headed by Helena Tomás and João Rodrigues, in a
total amount of € 276.000 have been approved and 5 submitted projects, accounting about € 772.000,
are awaiting the evaluation outcome (see Research projects submitted for external funding, page 14).
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In this period the new NMR and the LCMSMS was installed and started to work in routine mode.
Simultaneously, CQM acquired, with the pluri-annual programme, an automatic polarimeter (€ 7.661)
and, under the cover of DENDRALGENE FCT project, an inverted epi-fluorescent microscope and a
microplate reader with fluorescence/absorbance/luminescence, red sensitive PMT and dispenser
module was also installed (€ 66.500).
Regarding the scientific production, 14 papers and 7 proceedings were published during 2007, and 10
other papers are already accepted for publication (see 6.Publications). Additionally, 22 oral
communications and 50 posters were presented at scientific Meetings and Conferences.
It is worth mentioning several conferences where team members of CQM were present as organizers
(co-organizers or local organizers):
•
The 3rd Joint Summer School and Fall Work Meeting of FAME - Functionalized Advanced
Materials and Engineering of Hybrids and Ceramics (EU FP6 Network of Excellence), Funchal,
September 29-October 5, 2007. Co-organizer, 85 participants
•
The 1st Summer School of TERMIS – EU (European Chapter of the Tissue Engineering and
Regenerative Medicine International Society), Funchal, June 2007. Co-organizer, 70
participants.
•
The 3rd Marie Curie Cutting Edge Conference “Biomineralisation of Polymeric Materials,
Bioactive Biomaterials and Biomimetic Methodologies”, Funchal, June 2007. Local organizer,
90 participants.
In 2007, CQM has also received four visiting fellows:
•
Prof. Michael Murkovic from Food Chemistry Department (Graz University of Technology,
Austria) visited our research Centre for a 2 week period.
•
Profs. Pedro Núñez Coello and Ricardo Souto Suárez (University of La Laguna, Spain) stayed
with us to prepare collaboration projects and for a public presentation of IMANAC- INSTITUTO
DE MATERIALES Y NANOTECNOLOGÍA DE CANARIAS.
•
Prof. Sílvia Rocha (University of Aveiro, Portugal)
•
Prof. Gordon Cragg (National Cancer Institute, USA)
CQM current activities also include initiatives that have the objective of promoting the awareness of
science among youngsters. Two main projects were deployed in this area: “A Química é
Divertida/Chemistry is Fun” (several chemistry/biochemistry related activities performed during one
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week) and “Ocupação Científica de Jovens nas Férias”, both funded by Agência Nacional para a Cultura
Científica e Tecnológica (ANCCT) - Ciência Viva. Furthermore, CQM´s website, with 72 accesses/day in
2007 (26.400 accesses/year, 39% more than in 2006), is one of our privileged ways to contact and
spread our activities complemented by a regular service of press releases.
As a result, CQM often makes the news in the regional media. At least, 7 newspaper’s short news and 1
big interview (4 colour pages in the Sunday newspaper supplement of “Diário de Notícias da Madeira”)
were published in 2007. The interaction with the TV was also an important aspect of our activity in
2007. The total estimated time spent by the local TV station with information about CQM´s activities in
2007 was about 10 min in prime time news (50% more than in 2006). For the first time, a National TV
Channel (SIC TV) and a Cable Channel (PANDA Channel, based in Spain) covered the action “A Química
é Divertida/Chemistry is Fun” that took place during the National Week for Science and Technology (a
national activity sponsored by the Portuguese Government); in addition, PANDA Channel also invited us
for the production of 3 small science divulgation programs (of 7 minutes each) having chemistry as a
general topic. These programs have been broadcasted during December (2007) and January (2008) in
“TV Cabo”, the main Portuguese cable network.
The CQM member Pedro Pires continued his activity as a National Expert attached to the European
Commission in Brussels (Unit of Micro and Nanosystems) along the year of 2007 and José Câmara was
elected President of Chromatographic Group of the Portuguese Society of Chemistry.
1.3 OUTLOOK
The trajectory followed by CQM in the last years will soon be evaluated by FCT and we hope that it will
be possible to confirm the statement made by the evaluation panel of the proposal presented by CQM
to the National Program for Re-Equipment; the panel described CQM as “… a good group that deserves
support now. This project is very good and needs to be supported in the frame of a general policy
which will recognize the national interest to provide the Madeira Chemistry with large equipment.”.
We believe that with the new equipments recently installed and the reinforcement on human resources
during 2008-2009, CQM will be able to evolve both scientifically and in respect to the relation with the
surrounding society.
The concretization of such growth during the following years will depend on several factors such as:
•
Consolidation of the areas of intervention of the Research labs
•
Partnerships established with groups and institutions (in Portugal and abroad) that complement
the activities of the existing Labs and groups at CQM
•
Scientific cooperation between members of CQM
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•
Financial support (from FCT and from other institutions) for the regular maintenance of the
new equipments (NMR and LCMSMS) and for reinforcing our team (with adequate technical and
research staff).
As main goals for the next years, we have to:
•
Raise our number of papers per year. An average of at least two (2) papers/Ph. D./year is our
target for the next years
•
Raise our average IF-impact factor (2007: 2.6 (14 publications with IF in 21 published papers;
2006: 2.0 (21 publications with IF); 2005: 1.9 (7 publications with IF)
•
Increase the engagement with regional entities and private companies
•
Strengthen the critical mass in terms of human resources and small equipments
•
Organize advanced training programs with other national and international institutions in the
field of Natural Products and Materials
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2. Unit identification
Research Unit
Scientific Domain
Chemistry
Scientific Coordinator
João Manuel Cunha Rodrigues
Research Unit Address
Departamento de Química da Universidade da Madeira, Campus Universitário da Penteada
9000-390 Funchal
Phone
Fax
00351 291705100
00351 291705149
E-mail
URL address
[email protected]
http://cqm.uma.pt
Host Institution
Universidade da Madeira
Largo do Município - Colégio dos Jesuítas
9000-081 Funchal
NIF: 680041982
Management Institution
Universidade da Madeira
Largo do Município - Colégio dos Jesuítas
9000-081 Funchal
NIF: 680041982
Research Groups
Natural Products
Materials
Keywords
Food Chemistry
Phytochemistry
Molecular Materials
Nanochemistry
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3. Research team
By the end of 2007, CQM was constituted by 15 Ph. D. members (Table 1 and 2), 8 Ph. D. students
(Table 2), 14 co-workers including several undergraduate and graduate students (Table 3) and one
administrative staff member in a total of 37 team members. Two of the Post-docs fellows and 7 Ph. D.
students were directly supported through FCT fellowships.
Two of the collaborators (also former
students of the Chemistry Department/UMa) finished their studies outside Madeira: one presented her
Ph. D. project at the University of Bordeaux in November (Cátia Ornelas) and the other presented her
Master thesis at the University of Lisbon in last December (Rosa Perestrelo).
As previously stated in our report of 2006, along with the installation of the NMR and LCMSMS, it was
our goal to increase the number of members of CQM during the year of 2007. So, Dr. Viney Lather
joined CQM as one of our new Ph. D. members. Additionally we have three more Ph D. students in our
team - Ana Pereira, João Figueira and Pedro Branco. In March 2008, another Post-Doc fellow supported
by a FCT project (FUNCMETAL/PTDC/QUI/64202/2006) started his work at CQM (Dr. Swarup Maiti), and
two more post-doc fellows are expected to start working during 2008.
Figure 1. Part of the CQM team during the action “A Química é Divertida” with the
mascot of Panda Cable TV Channel.
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Name
Table 1. CQM Ph. D members and administrative staff at end of December 2007
%
Situation
Position
time Eligible part
Helena Maria Pires Gaspar Tomas Ph. D.
Assistant Professor
60
1.00
Helena Paula de Freitas Caldeira
Araújo
Ph. D.
Assistant Professor
60
1.00
João Manuel Cunha Rodrigues
Ph. D.
Assistant Professor
60
1.00
José Carlos Almeida Mesquita
Ph. D.
Assistant Professor
60
1.00
José Carlos Antunes Marques
Ph. D.
Associated Professor
60
1.00
José de Sousa Câmara
Ph. D.
Assistant Professor
60
1.00
Miguel Xavier Jesus Josefat
Fernandes
Ph. D.
Assistant Professor
60
1.00
Paula Cristina Machado Ferreira
Castilho
Ph. D.
Associated Professor
60
1.00
Pedro Filipe Duarte Louzeiro Pires Ph. D.
Assistant Professor
60
1.00
Visvaldas Kairys
Ph. D.
Post-doc fellow, FCT
100
1.00
Viney Lather
Ph. D.
Post-doc fellow, FCT
100
1.00
Susana Ramos
Ph. D.
Post-doc fellow,
INTERREG III B
100
1.00
César Esmeraldo Fernandes
Ph. D.
Researcher at LREC
40
0.00
Maria do Céu Goncalves da Costa
Ph. D.
Researcher at INETI
40
0.00
Cezar Florin Catrinescu
Ph. D.
Researcher in Romenia
20
0.00
Ana Maria Pereira Fráguas Mota
BSc(Hons)
Administrative officer
50
0.00
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Table 2. Ph. D. students
Name
Situation
Grant
%
time
Eligible part
José Luis Santos1
BSc(Hons)
Ph. D. grantee, FCT
100
0.00
Vanda Pereira2
BSc(Hons)
Ph. D. Grantee, FCT
100
0.00
Sandra Gouveia3
BSc(Hons)
Ph. D. grantee, FCT
100
0.00
Carla Alves4
MSc.
Ph. D. grantee, FCT
100
0.00
Ana Pereira2
BSc(Hons)
Ph. D. grantee, FCT
100
0.00
João Figueira5
BSc(Hons)
Ph. D. grantee, FCT
100
0.00
Pedro Branco3
MSc.
Ph. D. grantee, FCT
100
0.00
Tatiana Weinhold3
BSc(Hons)
Grantee, INTERREG IIIB
100
0.00
Supervisors: 1) Helena Tomás; 2) José Carlos Marques; 3) Paula Castilho; 4) Miguel Xavier Fernandes; 5) João Rodrigues
Table 3. Co-workers
Cátia Cristina Capelo Ornelas
BSc(Hons)
Ph. D. grantee, FCT
20
0.00
Maria Helena da Silva Oliveira
Figueira da Silva
BSc(Hons)
Invited Assistant
60
0.00
Rosa Maria De Sá Perestrelo
MSc.
60
0.00
Marisela Cátia Fernandes Pontes
BSc(Hons)
100
0.00
Susana Sargo
BSc(Hons)
Project Grantee, FCT
100
0.00
Catarina Grace
BSc(Hons)
100
0.00
Maria Elena Gonçalves Oramas
BSc(Hons)
Other
25
0.00
Manuel Gonçalves Jardim
BSc(Hons)
Other
100
0.00
Michael Caldeira
BSc(Hons)
Other
100
0.00
Neuza Paixão
BSc(Hons)
Other
100
0.00
Cátia Nóbrega
Undergraduate
student
Other
100
0.00
Inês Sousa
Undergraduate
student
Other
100
0.00
Fátima Rocha
BSc(Hons)
Other
20
0.00
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4. Scientific report
4.1 RESEARCH ACTIVITIES
This section reports the activities developed in 2007 by the CQM team members, research projects
submitted and under way, advanced training (Ph. D. and Post-doc projects), visiting fellows,
networking and main national and international collaborations.
Considering the importance for the future of the research center, the following items can be
highlighted:
•
The number of papers published and oral presentations in national and international meetings
•
The start of working in routine mode of the 400 MHz NMR equipment and the LCMSMS (see
Figure 2)
•
The number of Post-docs and Ph. D. proposals submitted and approved
•
The amount of research projects submitted for external funding.
Figure 2. LCMSMS Esquire 6000 (Bruker Daltonique)/Dionex. (REDE/1508/REM/2005 – FCT
National Programme for the Renewal of Scientific Equipment)
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4.2 SCIENTIFIC PROJECTS AND CONTRACTS
Currently the researchers of CQM are involved in 26 research projects, 17 funded by FCT (including 2
infra-structural projects – NMR and LCMSMS equipments, 9 Ph. D and 4 Post-doc research projects), 1
by the European Union Program INTERREG IIIB, 2 by the Agência Nacional para a Cultura Científica e
Tecnológica (ANCCT), and 6 other research projects in a total amount of € 6.512, supported by
University of Madeira through the funds to promote research supported by Totta & Açores/Santander
bank. Five research projects were submitted and are waiting for FCT evaluation.
COMMON PROJECTS:
1. The research Center is integrated into two national network facilities. One is in the field of NMR
(REDE/1517/RMN/2005; CQM: €278.179) and the other in the field of Mass Spectrometry
(REDE/1508/REM/2005; CQM: €165.749). Additionally, CQM is also a full member of the Portuguese
Nanotechnologies Network (PortugalNano) supported by Fundação para a Ciência e a Tecnologia.
2. In 2007, CQM continued the scientific divulgation project “A QUÍMICA É DIVERTIDA/CHEMISTRY IS
FUN”, supported by Agência Nacional para a Cultura Científica e Tecnológica (ANCCT) - Ciência Viva,
developed during the National Week for Science and Technology and this year was covered by a
National TV Channel (SIC TV) and a Cable TV Channel (PANDA Channel). Funding approved: €18.200,
POCI 43-2006, 2006-2008. Coordinator: Helena Tomás (SCIENTIFIC DIVULGATION ACTION)
3. As usual, CQM has participated in the project “Ocupação Científica dos Jovens nas Férias”, held
in July and supported with €2.300 by ANCCT - Ciência Viva. Four high school students participated in
research activities during two weeks. Coordinator: Helena Tomás. (SCIENTIFIC DIVULGATION ACTION)
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RESEARCH PROJECTS SUBMITTED FOR EXTERNAL FUNDING
SUBMITTED TO FCT:
1. “ETIOLOGY OF OSTEOPOROSIS: STUDY OF THE CAUSAL RELATIONSHIPS BETWEEN ELEMENTAL
CONCENTRATION PROFILES AND MECHANISMS OF BONE FORMATION AND RESORPTION” Funding
requested to FCT €199.416. Proponent institution: Centro de Física Atómica, University of
Lisbon, Portugal. Participant institution: UMa. PIC/IC/82947/2007. Principal investigator:
José Brito. CQM Team Member: Helena Tomás (in evaluation).
2. “Doença vascular: avaliação de factores de risco e de biomarcadores com efeito protector”.
Funding
requested
to
FCT:
€183.927.
Proponent
institution:
CITMA.
PTDC/SAU-
ESA/69070/2006, 2007-2010. Principal Investigator: Helena Caldeira (in evaluation).
3.
“BONEGENE- BONE TISSUE ENGINEERING BY GENE DELIVERY IN THREE-DIMENSIONAL STARCHBASED POLYMERIC SCAFFOLDS”. Funding requested: €196.500. Proponent institution: UMa.
Participant
institution:
3B´s
Research
Group,
University
of
Minho,
Portugal.
PTDC/BIO/67169/2006. Principal investigator: Helena Tomás (in re-evaluation).
4. “DESIGN OF SELECTIVE INHIBITORS FOR HUMAN PRO-COAGULANT PROTEASES”. Funding
requested to FCT: €120.000. Proponent institution: UMa. PTDC/BIA-PRO/72540/2006.
Principal investigator: Miguel X. Fernandes (Not approved).
5. “COMPUTER AIDED MOLECULAR MODELING OF PHOSPHODIESTERASE 3 INHIBITORS”. Funding
requested to FCT: €100.000. Proponent institution: UMa. PTDC/BIA-PRO/73128/2006.
Principal investigator: Miguel X. Fernandes (Not approved).
SUBMITTED TO OTHER INSTITUTIONS:
1. “ISOLATION, CHARACTERIZATION AND ANTIPROLIFERATIVE EVALUATION OF XANTHONES,
GUTTIFERONES AND THEIR ANALOGS”. Acções Integradas Luso Espanholas 2008 with
University of La Laguna, Spain. Principal Investigator: Paula Castilho (in evaluation)
2. “TRANSFORMATION OF CO2 TO DI-METHYL ETHER ON NOVEL MULTIFUNCTIONAL
CATALYSTS DERIVED FROM LAYERED INORGANIC MATERIALS”. ERA Chemistry application
with Institute of Catalysis and Surface Chemistry (Professor Ewa Serwicka-Bahranowska)
Polish Academy of Sciences, Krakow, Poland e University of Szeged (Professor Imre
Kiricsi)Hungary. Team Member: Paula Castilho (in evaluation)
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PROJECTS UNDER WAY OR CONCLUDED IN 2007:
1.
“ANTIVINMAC - DETERMINAÇÃO DO TEOR DE POLIFENÓIS, AMINOÁCIDOS E AMINAS
BIOGÉNICAS EM VINHOS DE CASTAS COMUNS AOS AÇORES, CANÁRIAS E MADEIRA”. Funded by
FEDER – INTERREG IIIB 05/MAC/2.3/M28, Total: €520.000; CQM partner: €220.000; 20052008. Principal Investigator: José Câmara
2.
“BIOPOLIS – BUILDING AN EUROPEAN BIOREGION”. Funded by FEDER – INTERREG IIIB –
05/MAC/2.3/C14, 5 partners, €708.000; 2006-2007. CQM partner: €176.000. Team member:
Paula Castilho
3.
“DENDRALGENE - DESIGN OF NEW GENE DELIVERY VECTORS BASED ON DENDRIMERS,
ALGINATE AND THE RGD SEQUENCE FOR BONE TISSUE ENGINEERING”. Funding requested to
FCT €200.000. Approved by FCT: €175.000. PTDC/SAU-BEB/71161/2006, 2007-2010.
Principal Investigator: Helena Tomás
4.
“CLAYCATS - MODIFIED PORTO SANTO CLAYS AS CATALYSTS FOR LIQUID PHASE ORGANIC
REACTIONS” with the Materials Research Institute, Sheffield Hallam Univ, UK, and Évora
University, Portugal. Funding requested to FCT €100.000. Approved by FCT: €72.000.
POCTI/CTM/47619/2002, 2004-2007. Principal Investigator: Paula Castilho
5.
“MOLECULAR INTERACTIONS IN LIQUIDS AND LIQUID MIXTURES”. Funding requested to FCT:
€76.500. Approved by FCT: €72.000.
POCTI/EQU/60963/2004. Principal Investigator:
Pedro Pires
6.
"NOVEL POLARISED MOLECULAR WIRES BASED ON TRANSITION METAL COMPLEXES OF DI(4PYRIDYL) HETEROCYCLES SPACERS BRIDGING LIGANDS". Funding requested to FCT: €85.710.
Approved by FCT: €85.710. POCTI/CTM/41495/2001, 2003-2007. Starting date: 1/4/2003.
Principal Investigator: João Rodrigues
7.
“IMPACT – IMPACTO DAS TECNOLOGIAS DE PRODUÇÃO NA QUALIDADE DO VINHO MADEIRA”.
Madeira Wine Company, Universidade da Madeira, Escola Superior de Biotecnologia.Funding
by ADI: €134.722, 2000-2007. Principal Investigator: José Carlos Marques
7.
“ACFA – APOIO AO CONTROLO DE FABRICO DE PRODUTOS ALIMENTARES”, Universidade da
Madeira (UMa). Funding through UMa – Apoio à investigação Fundo B. Funding requested to
UMa: €2000. Approved by UMa: €576; Covered period: 2007. Principal Investigator: José
Carlos Marques
8.
“IN VITRO STUDY OF THE INTERACTIONS BETWEEN PLASMID DNA AND DIFFERENT
GENERATIONS OF PAMAM (POLYAMIDOAMINE) DENDRIMERS - APPLICATION IN GENE DELIVERY”
with INEB-Instituto de Engenharia Biomédica, University of Porto, Portugal. Funding
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requested to UMa-Fundo B €2.000. Approved by UMa: €527. Covered period: 2007. Principal
investigator: Helena Tomás.
9.
“CONFORMATIONAL DYNAMICS OF THE CELL-PENETRATING PEPTIDE, PEP-1, IN MEMBRANE
MODEL SYSTEMS: COMPUTATIONAL SIMULATION AND SPECTROSCOPIC STUDIES”, Universidade
da Madeira (UMa). Funding through UMa – Apoio à Investigação Fundo B(UMa/Santander
Totta). Funding requested to UMa: €2000. Approved by UMa: €576. Covered period: 2007.
Principal Investigator: Miguel Fernandes
10.
“PASE – PROJECTO DE ALTERAÇÃO DO SISTEMA DE ESTAMPAGEM NA INDÚSTRIA DE BORDADO
DA MADEIRA”, Universidade da Madeira (UMa). Funding through UMa – Apoio à Investigação
Fundo B(UMa/Santander Totta). Funding requested to UMa: €2000. Approved by UMa: €634;
Covered period: 2007. Principal Investigator: José Carlos Marques
11.
“Pt(II) AND Pd(II) METALLOMOLECULAR WIRES USING 1,4-DIETHYNYLBENZENE DERIVATIVES
AS SPACERS LIGANDS”, Universidade da Madeira (UMa). Funding through UMa – Apoio à
Investigação Fundo B (UMa/Santander Totta). Funding requested to UMa: €2000. Approved
by UMa: €761; Covered period: 2007. Principal Investigator: João Rodrigues
12.
“SYNTHESIS OF A NEW METALLODENDRIMERS FAMILY USING RUTHENIUM, PLATINUM AND
PALLADIUM COMPLEXES AS BUILDING BLOCKS”, Universidade da Madeira (UMa). Funding
through UMa –Apoio à Investigação Fundo B(UMa/Santander Totta). Funding requested to
UMa: €2000, Approved by UMa: €761; Covered period: 2007. Principal Investigator: João
Rodrigues
13.
“BIONCOL project (2007-2008) – IDENTIFICATION OF VOLATILE BIOMERKERS IN INDIVIDUAL
WITH ONCOLOGIC PATHOLOGIES”. In collaboration with Centro Hospitalar do Funchal.
Fundos B (UMa/Santander Totta). Funding requested to UMa: €2000. Approved by UMa:
€450; Covered period: 2007. Principal Investigator: José S. Câmara.
14.
“AROMAVINREG– ANALYSIS AND CHEMICAL CHARACTERIZATION OF VOLATILE COMPONENTS IN
“VINHO REGIONAL TERRAS MADEIRENSES” BY HS-SPME/GC-QMS”. In collaboration with
Instituto do Bordado e do Vinho Madeira. Fundos B (UMa/Santander Totta). Funding
requested to UMa: €2000. Approved by UMa: €450; Covered period: 2007. Principal
Investigator: José S. Câmara.
15.
“PoViReM project (2007-2008) – EVALUATION OF POLIPHENOLIC COMPOSITION IN VINHO
REGIONAL TERRAS MADEIRENSES”. In collaboration with Instituto do Bordado e do Vinho
Madeira. Fundos B (UMa/Santander Totta). Funding requested to UMa: €2000. Approved by
UMa: €450; Covered period: 2007. Principal Investigator: José S. Câmara.
16.
“VALORIZAÇÃO INTEGRADA DE PRODUTOS RESIDUAIS DAS INDÚSTRIAS DE TRANSFORMAÇÃO
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DE FRUTAS DA MADEIRA”. Fundos B (UMa/Santander Totta). Funding requested to UMa:
€2000. Approved by UMa: €483; Covered period: 2007. Principal Investigator: Paula
Castilho.
17.
“NOVAS METODOLOGIAS DE ANÁLISE QUANTITATIVA DE ÁCIDO XIQUÍMICO EM EXTRACTOS
VEGETAIS”. Fundos B (UMa/Santander Totta). Funding requested to UMa: €2000. Approved
by UMa: €402; Covered period: 2007. Principal Investigator: Paula Castilho.
18.
“ORGANIC MODIFICATION OF BENTONITES FOR THE PREPARATION OF FUNCTIONAL
POLYMER/CLAY NANOCOMPOSITES”. Fundos B (UMa/Santander Totta). Funding requested to
UMa: €2000. Approved by UMa: €442; Covered period: 2007. Principal Investigator: César
Fernandes.
OTHER PROJECTS:
1.
“CELL ADHESION STUDIES ON HYDROPHOBIC PLLA MEMBRANES”, with the 3B’s group,
Biomaterials, Biodegradables and Biomimetics Dept. of Polymer Engineering, University of
Minho. Principal investigator: João Mano (UM). CQM Team Member: Helena Tomás.
Ph. D. AND POST-DOC PROJECTS UNDER WAY OR CONCLUDED IN 2007:
Ph. D. Projects
1.
“ARGILAS PILARIZADAS COMO CATALISADORES ÁCIDOS SÓLIDOS”, Ph. D. Project developed
by Dr. César Fernandes. PRODEP Funded. Supervisor: Paula Castilho with the co-supervision
of Chistopher Breen (Materials Research Institute, Univ. Sheffield Hallam, UK) (Concluded).
2.
“AVALIAÇÃO FITOQUÍMICA E FARMACOLÓGICA DE ALGUMAS PLANTAS AROMÁTICAS DA
FAMÍLIA DAS LABIATAE”, Ph. D. Project developed by MSc. Tatiana Weinhold. FEDER –
INTERREG IIIB 05/MAC/2.3/C14. Supervisor: Paula Castilho
3.
"BONE TISSUE ENGINEERING VIA LOCAL GENE DELIVERY", Ph.D. project developed by Dr. José
Luís Santos. Ph. D. Grant SFRH/BD/19450/2004/NG2H. Started in February 2005. Supervisor:
Helena Tomás with the co-supervision of Pedro Granja (INEB)
4.
“HEATING EFFECT IN THE FORMATION OF TYPICAL AROMA COMPOUNDS PRESENT IN MADEIRA
WINES”, Ph. D. project developed by Dr. Vanda Nulita Gomes Pereira, Ph. D. Grant
SFRH/BD/24177/2005. Started in February 2006. Supervisor: José Carlos Marques
5.
"ISOLAMENTO E CARACTERIZAÇÃO DE PRINCÍPIOS ACTIVOS DE PLANTAS PARA O COMBATE À
TUBERCULOSE", Ph. D. project developed by Dr. Sandra Cristina Gonçalves Gouveia. Ph.D.
- 17 -
Grant SFRH/BD/24227/2005. Started in February 2006. Supervisor: Paula Castilho
6.
“SPECTROSCOPIC AND COMPUTATIONAL STUDIES OF THE MECHANISM OF ACTION OF CELL
PENETRATING PEPTIDES”, Ph. D. project developed by Dr. Carla Sophia Alves. Ph. D. Grant
SFRH/BD/24547/2005. Evaluation: 4.4; minimum 4.4. Started in February 2006. Supervisor:
Miguel Fernandes
7.
“CARACTERIZAÇÃO QUÍMICA E HIERARQUIZAÇÃO (POR QUIMIOTERAPIA) DOS AROMAS DE
ENVELHECIMENTO DE VINHOS FORTIFICADOS”. Dr. Ana Cristina Pereira. Ph. D. Grant:
SFRH/BD/28660/2006. Evaluation: 4.4; minimum 4.4. Started in February 2007. Supervisor:
Pedro Saraiva (University of Coimbra) with the co-supervision of José Carlos Marques
8.
“NEW METALLOMOLECULAR WIRES BASED IN OLIGOTHIOPHENE BRIDGING SYSTEMS - A
SYSTEMATIC
STUDY”,
Dr.
João
Luís
Camacho
Baptista
Figueira.
Ph.
D.
Grant:
SFRH/BD/29325/2006. Evaluation: 4.7; minimum 4.2. Started in February 2007. Supervisor
Prof. João Rodrigues with the co-supervison of Prof. Kari Rissanen (Nanoscience Center,
Univ. Jyvaskyla, Finland)
9.
“APROVEITAMENTO DOS RESÍDUOS DAS INDÚSTRIAS DE FRUTOS PARA A PRODUÇÃO DE
BIOCOMBUSTÍVEIS”.
Dr.
Pedro
Miguel
Sena
Costa
Branco,
Ph.
D.
Grant:
SFRH/BD/32334/2006. Evaluation: 4.4; minimum 4.4. Started in September 2007.
Supervisor: Paula Castilho with the co-supervision of Fernanda Rosa (INETI/Dep. de Energias
Renováveis)
Post- Doc Projects
1.
"DEVELOPMENT OF A NOVEL FAMILY OF Pt (II) AND Pd(II) METALLOMOLECULAR WIRES USING
1,4-DIETHYNYLBENZENE DERIVATIVES AS SPACERS LIGANDS". Post-doc project developed by
Dr. Wojciech Czardybon (Silesian University of Technology, Gliwice, Poland). Post-doc Grant
SFRH/BPD/20695/2004. From October 2005 to June 2007. Evaluation: 4.4; minimum 4.1.
Supervisor: João Rodrigues with the co-supervision of Miguel Fernandes (CQM)
2.
“INTEGRATION
OF
GENOMIC
AND
STRUCTURAL
INFORMATION
TO
CHOOSE
NEW
THERAPEUTICAL TARGETS AND DEVELOP NEW DRUGS AGAINST MALARIA”. Post-doc project
developed by Dr. Visvaldas Kairys. Post-doc Grant SFRH/BPD/20716/2004. From June 2005
to 2008. Evaluation: 4.5; minimum 4.1. Supervisor: Miguel Fernandes
3.
“SYNTHESIS AND STRUCTURAL CHARACTERIZATION OF A NEW METALLODENDRIMERS FAMILY
USING RUTHENIUM, PLATINUM AND PALLADIUM COMPLEXES AS BUILDING BLOCKS”. Post-doc
Project developed by Dr. Zsolt Csók (Ph. D. in Chemistry by University of Veszprém
(Hungary), Post-doc Grant: SFRH/BPD/20663/2004. From October 2005 to April 2007.
Evaluation: 4.5; minimum 4.1. Supervisor: João Rodrigues
- 18 -
4.
“EFFECT OF CHIRALITY ON THE CONDUCTIVITY EFFICIENCY OF METALLOMOLECULAR WIRES
BASED ON EDOT DERIVATIVES”. Dr. Agata Renata Czardybon (Silesian University of
Technology, Gliwice, Poland). Post-doc Grant: SFRH/BPD/26680/2005. From October 2006
to June 2007. Evaluation: 4.7; minimum 4.4. Supervisor: João Rodrigues
5.
“HEMISYNTHESIS OF FINE CHEMICALS FROM NATURAL SUBSTANCES USING TITANIUM-MCM-41
AS CATALYSTS”. Post-doc project developed by Dr. Susana Ramos Post-doc Grant FEDER –
INTERREG IIIB 05/MAC/2.3/C14. From November 2006 to June 2007. Supervisor: Paula
Castilho
6.
“DESIGN AND DEVELOPMENT OF PPAR- SELECTIVE LIGANDS USING STRUCTURE BASED AND
LIGAND BASED COMPUTATIONAL APPROACHES”, Dr. Viney Lather, Post-doc Grant:
SFRH/BPD/30954/2006. Evaluation: 4.4; minimum 4.4. From October 2007 to September
2010. Supervisor: Miguel Fernandes
Ph. D. AND POST-DOC PROJECTS SUBMITTED TO FCT:
Ph. D. Projects
1. "EVALUATION OF THE AROMA POTENTIAL OF VITIS VINIFERA L. USED IN TERRAS MADEIRENSES
WINEMAKING. INFLUENCE OF ADDITION EXOGENOUS ENZYMES AND OF THE POLYMERIC
FRACTION IN THE WINE AROMA PROPRIETIES", Rosa Maria de Sá Perestrelo, Ph. D. Grant:
SFRH/BD/38855/2007. Evaluation: 4.58; minimum 3.85. Approved. Supervisor: José Câmara
with the co-supervision of Sílvia Maria Rocha (Universidade de Aveiro)
2. "DEVELOPMENT OF A METHODOLOGY FOR THE BIOMARKER DETECTION OF ALLERGIC
RESPIRATORY DISEASES BASED ON THE APPLICATION OF SOLID PHASE MICROEXTRACTION
COUPLED TO GAS CHROMATOGRAPHY. CONTRIBUTE FOR DEFINITION OF DIAGNOSTIC MEANS",
Michael Manuel Lima Caldeira, Ph. D. Grant: SFRH/BD/40374/2007. Evaluation: 4.36;
minimum 4.35. Approved. Supervisor: José Câmara with the co-supervision of Sílvia Maria
Rocha (Universidade de Aveiro)
3. “COMPUTATIONAL DESIGN OF HIV-1 INTEGRASE INHIBITORS USING A IMPROVED MODEL FOR
CALCULATION
OF
BINDING
AFFINITIES”,
Nigus
Dessalew
Ambaye,
Ph.
D.
Grant:
SFRH/BD/39362/2007. Evaluation: 4.5; minimum 4.4. Approved. Supervisor: Miguel X.
Fernandes.
- 19 -
Post-doc Projects
1.
“NANOTEMPLATING OF CALCIUM PHOSPHATES FOR GENE DELIVERY USING DENDRIMERS”, Dr.
Vuk Uskokovic, Post-doc Grant: SFRH/BPD/38775/2007. Evaluation: 4.07; minimum 4.06.
Approved. Supervisor: Helena Tomás with the co-supervision of João Rodrigues (to be
started in November 2008).
2.
“SYNTHESIS OF METALLODENDRIMERS BASED ON 2,4,6-TRI-SUBSTITUED-1,3,5-TRIAZINE
DERIVATIVES”, Dr. Manoj Trivedi, Post-doc Grant: SFRH/BPD/37576/2007. Evaluation: 4.3;
minimum 4.3. Approved. Supervisor: João Rodrigues (to be started in November 2008).
3.
“COMPUTATIONAL MODELING OF PHOSPHODIESTERASE 3 INHIBITORS”, Dr. Visvaldas Kairys,
Post-doc Grant: SFRH/BPD/41787/2007. Evaluation: 4.1; minimum 3.85. Approved.
Supervisor: Miguel X. Fernandes (to be started in April 2008).
NETWORKS
1.
Portuguese National Nuclear Magnetic Resonance Network (PTNMR). http://ptnmr.dq.ua.pt/
2.
Portuguese National Mass Spectrometry Network (RNEM).
3.
Portuguese
Nanotechnology
Network.
Team
Member:
João
Rodrigues
http://www.portugalnano.eu/
4.
“CYTED – Subprogramme X: Química Fina e Farmacêutica, Projecto X.11 Proyecto
Iberoamericano de Búsqueda y Evaluación de Agentes Naturales Antituberculosos
(PIBATUB)”, 2003-2008. Team member: Paula Castilho
4.3 ORGANISED MEETINGS, CONFERENCES AND SHORT COURSES
•
3rd Joint Summer School and Fall Work Meeting of FAME - Functionalised Advanced Materials and
Engineering of Hybrids and Ceramics (EU FP6 Network of Excellence, Funchal, September 29October 5, 2007. Co-organizer, 85 participants.
•
International Workshop on Natural Products - Potencial Terapêutico da Flora da Macaronésia,
BIOPOLIS INTERREG project, July 26-28, 2007, Universidade da Madeira. 25 participants.
•
1st Summer School of TERMIS – EU (European Chapter of the Tissue Engineering and Regenerative
Medicine International Society), Funchal, June 2007. Co-organizer, 70 participants.
- 20 -
•
3rd Marie Curie Cutting Edge Conference “Biomineralisation of Polymeric Materials, Bioactive
Biomaterials and Biomimetic Methodologies”, Funchal, June 2007. Local organizer, 90
participants.
•
2nd meeting of ANTIVINMAC PROJECT (Interreg IIIB 05/MAC/2.3/M28), Universidade da Madeira,
February 1-3, 2007, 20 participants.
•
2nd Materials Line Meeting/CQM, Funchal, January 26th, 2007, 30 participants.
4.4 VISITING FELLOWS
•
Prof. Michael Murkovic from the Food Chemistry Department (Graz University of Technology,
Austria) visited our research Centre, for 2 weeks period to prepare the research work with José
Carlos Marques and to present a Conference entitled “Toxic substances in heated foods", 9th of
February (Supported by Socrates Programme).
•
Profs. Pedro Núñez Coello and Ricardo Souto Suárez (University of La Laguna) stayed with us
to prepare, with the Materials Line, future collaborations projects and for a public presentation of
IMANAC- INSTITUTO DE MATERIALES Y NANOTECNOLOGÍA DE CANARIAS, September 18th.
•
Prof. Sílvia Rocha (University of Aveiro, Portugal), one month of sabbatical period.
•
Prof. Gordon Cragg (National Cancer Institute, USA), stayed with us for a workshop and to
prepare future work in the field of Natural Products.
4.5 STAYS IN OTHER RESEARCH CENTERS
•
João Rodrigues (Ph. D.):
Visitant Professor at NanoScience Center/Chemistry Department of University of Jyväskyla
Finland. From October 28th till November 6th, 2007 (SOCRATES/ERASMUS Programme);
4.6 OTHER ACTIVITIES BY TEAM MEMBER
•
João Rodrigues (Ph. D.):
Referee for Inorganic Chemistry Communications.
Referee for Journal of Coordination Chemistry.
Referee of KGCM - International Conference on Knowledge Generation, Communication and
Management, July 8-11, 2007 – Orlando, Florida, USA.
- 21 -
Member of the Scientific Committee and Review Board of INTERNATIONAL CONFERENCE ON
COMPOSITES/NANO ENGINEERING (ICCE 15), Haikou, Hainan Island, China, July 15-21, 2007.
NMR Unit Manager and member of the Management Committee of the Portuguese Nuclear
Magnetic Resonance Network (http://ptnmr.dq.ua.pt).
Member of the Management Committee of the Portuguese Mass Spectrometry Network.
Co-organizer of the 3rd Joint Summer School and Fall Work Meeting of FAME - Functionalized
Advanced Materials and Engineering of Hybrids and Ceramics, EU FP6 Network of Excellence,
Funchal, Portugal, September 30-October 5, 2007.
Participation, as member of the jury, in the discussion of Cátia Ornelas Ph D. Thesis (public
defense), “Synthese et Ingenierie de Nanomateriaux Dendritiques Supramoleculares pour la
Reconnaissance, la Catalyse et L’ Electronique Moleculaire” (Doctorat Université Rennes 1
mention Chimie), presented and discussed at Bordeaux University, France, 9 of November,
2007.
Participation, as member of the jury, in the discussion of César Fernandes Ph D. Thesis (public
defense), “Modified Clays as Solid Acid Catalysts”, presented and discussed at Madeira
University, Funchal, 27 of April, 2007.
•
Paula Castilho (Ph. D.):
Guest editor of Phytochemistry Reviews (2005-2007).
Representative of Portugal and Spain in the Large Committee of Phytochemical Society of
Europe (2005-2008).
Member of the Scientific Committee of the 2nd Meeting YBIM Young Biomedical Investigators of
the Macaronesia November 10-13th, 2007, Lanzarote, Canary Islands.
Organizer of the International Workshop on Natural Products - Potencial Terapêutico da Flora
da Macaronésia, BIOPOLIS INTERREG project, July 26-28th, 2007, Universidade da Madeira.
•
Miguel Fernandes (Ph. D.):
Referee for Biochemical Journal
Referee for Journal of Physical Chemistry B
Reviewer for the Health Research Board of Ireland
Organizer of the 2nd Materials Line Meeting
•
Helena Tomás (Ph. D.):
Referee for Biomaterials
- 22 -
Organizer of the science divulgation action: A QUÍMICA É DIVERTIDA/Chemistry is
Fun (November 2007).
Organizer of several science divulgations TV programs (for PANDA TV Channel).
Organizer of several school visits to CQM laboratories.
Participation in the master thesis discussion (arguente) of Sandra Luna, “Novel polymeric
systems based on natural materials: development and biological performance” (April 2007),
University of Minho.
Co-organizer of 1st Summer School of TERMIS – EU (European Chapter of the Tissue Engineering
and Regenerative Medicine International Society), Funchal, June 2007.
Local organizer of 3rd Marie Curie Cutting Edge Conference “Biomineralisation of Polymeric
Materials, Bioactive Biomaterials and Biomimetic Methodologies”, Funchal, June 2007.
•
José Câmara (Ph. D.):
Organizer of the 2nd meeting of ANTIVINMAC PROJECT (Interreg IIIB 05/MAC/2.3/M28).
Mass Spectrometry Unit Manager of the Portuguese Mass Spectrometry Network (RNEM,
REDE/1508/REM/2005).
Participation in the master thesis discussion (arguente) of Rosa Perestrelo, “Aplicação de
metodologias Solventless para análise da fracção volátil de amostras de vinhos Vitis vinifera L.”
(December 2007), University of Lisbon.
•
José Carlos Marques (Ph. D.):
Scientific Committee Member of AERAM (Agência Regional da Energia e Ambiente da Região
Autónoma da Madeira).
Member of the Expert Board of Barómetro Regional da Qualidade (Direcção Regional da
Qualidade/Vice-presidência do Governo Regional da Madeira).
Coordinator of post-graduated Course on Health and Safety at Work.
Scientific Committee Member of 2ª Conferência Nacional da Sociedade Portuguesa de
Metrologia (3-4 Outubro de 2007), Funchal.
•
Pedro Pires (Ph. D.):
European Commission Expert in the Unity G2 (Microsystems) of DG Information Society and
projects evaluator of ICT-2007.3.2 (Organic and large-area electronics, visualization and display
systems) and ICT-2007.3.6 (Micro/nanosystems) of 7th Framework Program.
•
Sandra Gouveia (Ph. D. Student):
- 23 -
Two periods of studies at Food Chemistry Department (Graz University of Technology, Austria)
as a part of Ph. D. program (May 21-June 11th; September 1-23rd).
•
João Figueira (Ph. D. Student):
6 months work period at NanoScience Center/Chemistry Department of University of Jyväskyla
Finland as a part of Ph. D. Program.
4. 7 AWARDS AND OTHER MERITS
•
Pedro Pires was appointed as National Expert assigned to the Unit of Micro and Nanosystems of
the DG Information Society (INFSO G2) European Commission, Brussels.
•
José Câmara was elected President of Chromatography Group of the Portuguese Society of
Chemistry.
4. 8 MAIN COLLABORATIONS
For a research centre located in an Island, the collaborations with other institutions, private companies
and research groups in Portugal and abroad are particularly important. These collaborations give us the
access to equipments not available at our research Centre and university, but also permit the exchange
of knowledge, students and researchers, increasing the visibility of our Centre and improving our
scientific activity.
International Research Units
•
Center for Advanced Research in Biotechnology (USA)
•
Institute of Physiology, Academy of Sciences of the Czech Republic
•
Instituto Canário de Investigación del Cáncer (Spain)
•
Instituto Politécnico Nacional (Mexico)
•
Materials Res. Institute (Univ. de Sheffield Hallam, UK)
•
M-NIMBS, Michigan Nanotechnology Institute for Medicine and Biological Sciences (Michigan
Univ., USA)
•
NanoScience Center (Univ. de Jyvaskyla, Finland)
•
NEC – Corporation (Japan)
•
UNIVALI (Brazil)
•
University of de Antwerp (Belgium)
- 24 -
•
University of Barcelona (Spain)
•
University of Bordeaux I (France)
•
University of Corsica (France)
•
University of Graz (Austria)
•
University of Humboldt (Humboldt-Universität) (Germany)
•
University of La Laguna (Spain)
•
University of Murcia (Spain)
•
University of Pisa (Italy)
•
University of Virginia-School of Medicine (USA)
National Research Units
•
3Bs-Universidade do Minho
•
Centro de Física Atómica, Universidade de Lisboa
•
Faculdade de Ciências da Universidade de Lisboa
•
INEB-Universidade do Porto
•
INETI
•
ISA-Instituto Superior de Agronomia
•
IST-Instituto Superior Técnico
•
Universidade dos Açores
•
Universidade Católica Portuguesa
•
Universidade de Évora
Private and Governmental Institutions and Companies
•
APRAM - Portos da Madeira
•
Direcção Regional da Agricultura
•
Direcção Regional de Saneamento Básico
•
Instituto do Vinho e do Bordado da Madeira
•
Jardim Botânico da Madeira
•
Madeira Wine Company
- 25 -
5. Indicators
2007
2007
2008
Expected Achieved Expected
PUBLICATIONS
26
22
25
Books
0
0
1
Papers in internacional journals
25
21
22
Papers in national journals
1
1
2
COMMUNICATIONS
53
90
40
In internacional meetings
30
42
15
In national meetings
10
30
10
Reports
10
10
12
Organization of seminars and conferences
3
8
3
ADVANCED TRAINING
5
5
3
Ph. D. thesis
1
1
0
Master thesis
1
1
0
Others
3
3
3
OTHER INDICATORS
0
0
0
Models
0
0
0
Computational applications
1
0
1
Pilot plants
0
0
0
Prototypes
0
0
0
Patents
0
0
0
Others
0
0
1
(Unit: numbers)
- 26 -
6. Publications
During the year of 2007, the research center has published a total number of 21 papers (14 papers in
journals with impact factor and 7 proceedings). Ten additional papers and one chapter book have
already been accepted to be published in 2008 and other 11 papers were submitted by the end of 2007.
The number of oral communications in international conferences was 10 out of 22, and 50 posters were
also presented in the last year.
Comparing these results with the results for the previous year, an increase in the number of
communications was observed (16 and 41 oral and poster presentations, respectively, in 2006) and,
most important, an improvement in the average impact factor (2.0 in 2006 to 2.6 in 2007). Considering
only the number of papers in journals with impact factor, from 2004 to 2007, an average of 12
papers/year or 1 paper/team member (average of 12 Ph.D./year) was achieved. Nevertheless, if we
considerer the total number of publications reached in the same period for all CQM team (76
publications), an average of 20 publications/year or 1.6 papers/team member was achieved.
Figure 3. Evolution of the number of publications from 2004 to 2007.
With the installation of the NMR and LCMSMS equipments during 2007, an increase in the overall
scientific production is expected in the near future. Based on the number of papers already accepted
- 27 -
and submitted, as well as on the number of communications presented during 2007, we expect to
increase the number of publications to 25-30 papers, and maintain the average impact factor.
BOOKS / BOOKS CHAPTERS
1. Alves C. S., Kairys V., Fernandes M. X.; Domain motions associated with substrate and inhibitor
binding: The relevance of distance Matrixes; book chapter in “Protein Conformation: New
Research”, Nova Publishers. Accepted.
THESIS
1.
Fernandes C.; Argilas Pilarizadas como Catalisadores Ácidos Sólidos; Departamento de Química
da Universidade da Madeira. Supervisor: Paula Castilho with the co-supervision of Chistopher
Breen (Materials Research Institute, Univ. Sheffield Hallam, UK). (Ph. Thesis)
2.
Perestrelo R; Aplicação de Metodologias Solventless para Análise da Fracção Volátil de Amostras
de Vinhos Vitis vinifera L.; FCUL, Departamento de Química e Bioquímica; December 20.
Supervisors: José Manuel Nogueira (FCUL) and José S. Câmara (UMa/CQM). (Master Thesis)
3.
Sousa M. I. J.; Identificação de Alvos Moleculares na Terapia Anticancerígena; Centro de Química
da Madeira; Departamento de Química da Universidade da Madeira. December 6; Supervisor:
Miguel Xavier Fernandes. (Graduation Thesis)
4.
Jardim M.; Síntese e Caracterização de Compostos Polinucleares de Ruténio e Síntese e
Caracterização de Diacetiletos de Ruténio; Centro de Química da Madeira; Departamento de
Química da Universidade da Madeira. September 19; Supervisor: João Rodrigues. (Graduation
Thesis)
PUBLISHED PAPERS IN INTERNATIONAL JOURNALS WITH IMPACT FACTOR (IF)
1.
Caldeira M., Rodrigues F., Perestrelo R., Marques J. C., Câmara J. S.; Comparison of Two
Extraction Methods for Evaluation of Volatile Constituents Patterns in Commercial Whiskeys.
Elucidation of the Main Odour-active Compounds; Talanta; 74; 78-90; 2007;
doi:10.1016/j.talanta.2007.05.029. (IF: 2.810)
2.
Câmara J.S., Alves M.A., Marques J.C.; Classification of Boal, Malvazia, Sercial and Verdelho
Wines Based on Terpenoid Patterns; Food Chem.; 101; 475-484; 2007. (IF: 2.433)
3.
Câmara J.S., Marques J.C., Perestrelo R.M., Rodrigues F., Oliveira L., Andrade P., Caldeira M.;
Comparative Study of the Whisky Aroma Profile Based on Headspace Solid Phase Microextraction
Using
Different
Fibre
Coatings;
J.
Chromatogr.
A;
1150;
198-207;
2007;
doi:10.1016/j.chroma.2006.09.014. (IF: 3.554)
4.
Castilho P., Liu K., Rodrigues A. I., Feio S., Tomi F., Casanova J.; Composition and Antimicrobial
Activity of Clinopodium Ascendens (Jordan) Sampaio from Madeira; Flavour Frag. J.; 23; 139144; 2007; doi:10.1002/ffj.1771. (IF: 0.868)
5.
Chellappan S., Kiran Kumar Reddy G. S., Ali A., Nalam M. N., Anjum S. G., Cao H., Kairys V.,
Fernandes M. X., Altman M. D., Tidor B., Rana T. M., Schiffer C. A., Gilson M. K.; Design of
Mutation-resistant HIV Protease Inhibitors with the Substrate Envelope Hypothesis; Chem. Biol.
Drug. Des.; 69; 298-313; 2007. (IF: Chemical Biology & Drug Design is included in the ISI®
Biology & Biochemistry category and will be awarded a full Impact Factor® in 2008.)
- 28 -
6.
Chellappan S., Kairys V., Fernandes M. X., Schiffer C., Gilson M. K.; Evaluation of the substrate
envelope hypothesis for inhibitors of HIV-1 protease; PROTEINS: Structure, Function, and
Bioinformatics; 68; 561-567; 2007. (IF: 3.73)
7.
Cso´k Z., Gandum C., Rissanen K., Tuz A., Rodrigues J.; Syntheses and Characterization of
Novel Ruthenium Complexes Based on 1,3-Dicyanobenzene; J. Organomet. Chem.; 692; 52635271; 2007; doi:10.1016/j.jorganchem.2007.08.012. (IF: 2.332)
8.
Fernandes C., Catrinescu C., Castilho P., Russo P.A., Carrott M.R, Breen C.; Catalytic
Conversion of Limonene Over Acid Activated Serra de Dentro (SD) bentonite; Appl. Catal. AGen.; 318; 108-120; 2007. (IF: 2.630)
9.
Kairys V., Fernandes M. X.; SitCon: Binding Site Residue Conservation, Visualization and Protein
Sequence-to-Function Tool; Int. J. Quantum Chem.; 107; 2100–2110; 2007. (IF: 1.182)
10. Luna-Herrera J., Costa M. C., Gonzalez H., Rodrigues A., Castilho P.; Synergistic
Antimycobacterial Activities of Sesquiterpene Lactones from Laurus spp; J. Antimicrob.
Chemother.; 59; 548-552; 2007; doi:10.1093/jac/dkl153. (IF: 3.891)
11. Nascimento M.L., Mueller W.D., Carvalho A.C., Tomás H.; Electrochemical Characterization of
Cobalt-based Alloys Using the Mini-cell System; Dent. Mater.; 23; 369-373; 2007; doi:
10.1016/j.dental.2006.01.026. (IF: 2.381)
12. Paixão N., Perestrelo R., Marques J. C., Câmara J. S.; Relationship Between Antioxidant
Capacity and Total Phenolic Content of Red, Rose and White Wines.; Food Chem.; 105; 204-214;
2007; doi:10.1016/j.foodchem.2007.04.017. (IF: 2.433)
13. Pontes M., Marques J. C., Câmara J. S.; Screening of Volatile Composition From Portuguese
Multifloral Honeys Using Headspace Solid-phase Microextraction-gas Chromatography-quadrupole
Mass Spectrometry; Talanta; 74; 91-103; 2007; 10.1016/j.talanta.2007.05.037. (IF: 2.810)
14. Vertlib V., Figueira J., Mesquita J., Rodrigues J., Nättinen K., Rissanen K.; A Trinuclear Aqua
Cyano-bridged Ruthenium Complex [{(η5-C5H5)(PPh3)2Ru(μ-CN)}2RuCl2(PPh3)(H2O)][PF6]: Synthesis,
Characterization and Crystal Structure;
Eur. J. Inorg. Chem.; 13; 1920–1924; 2007;
doi:10.1002/ejic.200601050. (IF: 2.704)
PUBLISHED PAPERS IN INTERNATIONAL JOURNALS WITH PEER REVIEW BUT WITHOUT IMPACT
FACTOR
1. --ACCEPTED PAPERS IN INTERNATIONAL JOURNALS (by the end of 2007)
1. Altman M. D., Akbar A., Reddy G. S. K. K., Nalam M. N. L.., Anjum S. G., Cao H., Kairys V.,
Fernandes M. X., Chellappan S., Gilson M. K., Rana T. M, Schiffer C. A., Tidor B.; HIV-1 protease
inhibitors from inverse design in the substrate envelope exhibit subnanomolar binding to drugresistant variants; accepted for publication in J Am Chem Soc.. (IF: 7.696)
2. Castilho P. C., Weinhold T.S., Savluchinske-Feio S., Pereira P.T., Gouveia S.C., Rodrigues A.I.,
Venâncio F.; Chemical Composition and Bioactivity of Essential Oils and Extracts from Oregano
from Madeira Island, Portugal; accepted for publication in Acta Horticulturae in April 2007 (IF:
????)
3. Castilho P., Gouveia S., Rodrigues A. I; Quantification of Artemisinin and Camphor in Artemisia
Annua Extracts by 1H-NMR; accepted for publication in Phytochemical Analysis in October 2007;
XX; XXX-XXX; 2008.(IF: 1.228)
- 29 -
4. Figueira J., Rodrigues J., Russo L. and Rissanen K.; Three Ethynyl-2,5-bis(alkyloxy)benzene
Derivatives; Acta Cryst.; C64; o33-o36; 2008; doi:10.1107/S0108270107065523. (IF: 0.896)
5. Louh G. N., Lannang A. M., Mbazoa C. D., Tangmouo J. G., Komguem J., Castilho P., Ngninzeko
F.N., Qamar N., Lontsi D., Choudhary M. I., Sondengam B. L.;Polyanxanthone A, B and C, three
xanthones from the wood trunk of Garcinia polyantha Oliv; Phytochemistry; 69; 1013-1017;
2008. (IF: 2.417)
6. Pereira V., Pontes M., Câmara J.S., Marques J.C.; Simultaneous analysis of free amino acids and
biogenic amines in honey and wine samples using in loop OPA-derivatization procedure; accepted
for publication in J. Chromatogr. A, 2008; doi:10.1016/j.chroma.2007.12.014. (IF: 3.554)
7. Perestrelo R., Caldeira M., Rodrigues F., Câmara J.S.; Volatile Flavour Constituents Patterns of
Terras Madeirenses Red Wines Extracted by Dynamic Headspace Solid-Phase Microextraction;
accepted for publication in J. Sep. Science, 2008; doi: 10.1016/j.aca.2007.12.041. (IF: 2.532)
8. Rodrigues F., Caldeira M., Marques J.C., Câmara J.S.; Development of a dynamic headspace
solid-phase microextraction procedure coupled to GC-qMSD for evaluation the chemical profile in
alcoholic beverages; accepted for publication in Anal. Chimica Acta; 609; 82-104; 2008. (IF:
2.894)
9. Pontes M., Marques J.C., Câmara J.S.; Multivariate characterization of different species of
Passiflora fruits according to their volatile composition; accepted for publication in Food
Chemistry; 2008. (IF: 2.433)
10. Ornelas C., Ruiz J., Rodrigues J., Astruc D.; Visible-light Photolytic Synthesis of Multinuclear and
Dendritic Iron-Nitrile Cationic Complexes; accepted for publication in Inorg. Chem. (IF: 3.911)
SUBMITTED PAPERS (at the end of 2007)
1. Castilho, P.C., Feio, S.S.; Antimicrobial activity and composition of essential oils of Myrtus
communis growing wild in Madeira and Azores, Portugal;
submitted to Natural Product
Communication (invited submission to especial issue).
2. Komguem J., Lannang A. M., Tangmouo J.G., Castilho P.C., Kuete V., Ngounou, F. N., Devkota K.
P., Lontsi D., Sondengam B. L.; Allylation of smeathxanthone B and Cheffouxanthone;
antimicrobial activities of derivatives; submitted to Phytochemistry, October, 2007.
3. Castilho P.C., Feio S. S. , Venancio F. P., Weinhold T. S., Gouveia S. C., Pereira P. T.; Essential
Oils and Extracts from Oregano from Madeira Island, Portugal - their antimicrobial and
antioxidant activities; submitted to International Journal of Food Mibrobiology, November
2007.
4. Paixão N., Pereira V., Marques J.C., Câmara J.S.; Validation of a methodology for quantification
of low-molecular-mass polyphenols in different wines by high-performance liquid
chromatography-photodiode array detection; submitted to J. Sep Science.
5. Pereira A.C., Saraiva P.M., Câmara, J.S., Reis M.S., Marques J.C.; Differentiation of liqueur
wines using a multivariate statistical analysis of aromatic profiles; submitted to Analytical
Bioanalytical Chemistry.
6. Pereira V., Pontes M., Paixão N., Câmara J.S., Cacho J., Marques J.C.; Major volatiles obtained
from model systems simulating the Madeira wines heating; submitted to Food Chemistry;
7. Tomás H., Fernandes L.F., Calabretta A., Pereira J.A., Costa M.A., Fernandes M.H.; Osteoblastic
differentiation over an adsorbed collagen layer, over the surface of collagen gels and inside
collagen gels – a comparative study; submitted to Calcified.Tissue Int.
- 30 -
8. Tomás H., Fernandes L.F., Marques J.C., Costa M.A., Fernandes M.H.; Gel systems of collagen
type I, proteoglycans and TGF-β1 – in vitro fibrillogenesis and growth factor release; submitted to
J. Mater. Sci. Mater. M.
9. Alves N.M., Shi J., Oramas E., Santos J.L., Tomás H., Mano J.F.; Bioinspired superhydrophobic
poly(L-lactic acid) surfaces prevent the adhesion and proliferation of bone marrow derived cells;
submitted to J. Biomed. Mater. Res. Part A.
10. Santos J.L., Oramas E., Pêgo A.P., Granja P.L., Tomás H.; Low-transfection efficiency is
sufficient for in vitro osteoblastic differentiation of mesenchymal stem cells – use of PAMAM
dendrimers delivery systems; submitted to Gene Therapy.
INTERNATIONAL CONFERENCE PROCEEDINGS WITH PEER REVIEW
1.
Fernandes M., Pereira R., Albuquerque, F.M., Câmara, J.S., Marques, J.C.; Madeira Table
wines: evolution and organoleptic characterization; V World Wine Forum, La Rioga (SP), 2006.
2.
Pereira V., Perestrelo R., Câmara J. S., Ferreira A. C., Perez J. P., Marques J. C.; Effect of the
heating step in the volatile composition of Madeira Wines; 3rd Central European Congress on
Food; Sofia, Bulgaria; 2007.
3.
Pereira V., Pontes M., Paixão N., Câmara J. S., Marques J. C.; Efeito da estufagem na
composição do vinho Madeira; Actas do 8º Encontro de Química dos Alimentos, Beja, Portugal; 4
– 7 de Março, pp. 205 – 208, 2007.
4.
Perreira, C., Costa, S., Marques, J.C.; Metodologia para a Análise e Controlo de Riscos em
Empresas Industriais de Tratamento de Resíduos Sólidos Urbanos e Equiparados, II Encontro
Nacional de Riscos, Segurança e Fiabilidade, promovido pela European Safety and Reliability
Association, Lisboa, 13-15 de Novembro de 2007.
5.
Pontes M., Pereira V., Albuquerque F., Câmara J.S., Ferreira A.C., Marques J.C.; Evolution of
free amino acids in young madeira wines submited to controled heating conditions; Enologie,
Bordéus, France, 2007.
6.
Rodrigues J.; An Organometallic Approach to Molecular Electronics; Proceedings of FAME Functionalised Advanced Materials and Engineering of Hybrids and Ceramics, EU FP6 Network of
Excellence, Funchal, Portugal, 247-284, 2007.
7.
Sousa, J.A., Reynolds, A.P., Delgado, I.S., Marques, J.C., Teixeira, L.M., Jesus, C.G.; Estudo
comparativo de diferentes métodos na avaliação de incertezas de medição em metrologia
química; 2ª Conferência Nacional de Metrologia, Metrologia e Inovação, Funchal, 3-4 Outubro
2007-11-15.
ABSTRACTS IN SCIENTIFIC MEETINGS
ORAL COMMUNICATIONS
1. Caldeira M., Antunes M., Aveiro F., Castilho P., Rocha S.M., Câmara J.S.; Cancer volatile
biomarker profile in biological fluids by headspace solid-phase microextraction-gas
chromatograph-mass spectrometry; V Encontro Nacional de Cromatografia; Aveiro, Portugal,
Dezembro 2007, page 25-26.
2. Caldeira M., Antunes M., Aveiro F., Castilho P., Rocha S.M., Câmara J.S.; Establishment of
volatile biomarker profile in blood and urine of individual with oncologic pathologies; 31st
International Symposium on Capillary Chromatography & Electrophoresis; Albuquerque, New
Mexico USA. November 2007.
3. Caldeira M., Rodrigues F., Perestrelo R., Marques J.C., Câmara J.S.; Dynamic Headspace SolidPhase Microextraction Procedure Coupled to GC-qMS for Evaluation of the Chemical Profile in
- 31 -
Alcoholic Beverages; ExTech®2007Ninth International Symposium on Advances in Extraction
Technologies, Älesund, Norway. June 2007, page 48-49.
4. Castilho P.C., Nunes D.M., Marques, J.C.; Extracção e Caracterização de subprodutos da
Graínha de uva: óleo vegetal e polifenóis; Jornadas do projecto ANTIVINMAC 05/MAC/2.3/M28
Sala Senado Piso –2 Campus da Penteada, Universidade da Madeira, 2 e 3 de Fevereiro de 2007.
5. Castilho P.C., Weinhold T.S., Feio S., Venâncio F.; Chemical Composition and Bioactivity of
Essential Oils and Extracts from Oregano from Madeira Island, Portugal; 1st International
Medicinal and Aromatic Plants Conference in Culinary Herbs, Antalya, Turkey, 29th April – 04th
May 2007.
6. Castilho P.C.; Valorisation of Essential Oils by Chemical and Biotechnological Modification of Key
Components; Keynote lecture KL02, 38th International Symposium on Essential Oils (ISEO), Graz,
Austria, page 5, 9th - 12th September 2007.
7. Costa M.C., Castilho P.C., Correia D.; O Espaço Biológico das Lactonas Sesquiterpénicas;
Workshop de Produtos Naturais, Funchal, Portugal, 26 – 28 July, page 25, 2007.
8. Csók Z., Gandum C., Mesquita J., Rodrigues J., Robalo M., Russo L., Natinnen K., Rissanen K.;
Syntheses, Characterization and Crystal Structures of Some Novel Organometallic Complexes
Based on 1,3-Dicyanobenzene; 2nd Materials Line Meeting/CQM, Funchal, Portugal, January 26th,
2007.
9. Czardybon W., Rodrigues J., Rissanen K.; Novel Group of Metallomolecular Pd(II) and Au (II)
Wires; 2nd Materials Line Meeting/CQM, Funchal, Portugal, January 26th, 2007.
10. Figueira J., Vertilib V., Rodrigues J., Rissanen K.; Novel Polarised Molecular Wires Based on
Transition Metal Complexes of di(4-pyridyl)heterocycles Spacers Bridging Ligands; 2nd Materials
Line Meeting/CQM, Funchal, Portugal, January 26th, 2007.
11. Gouveia S.C., Castilho P.C, Murkovic M.; Novos métodos de avaliação da actividade antioxidante
de extractos de plantas; Workshop de Produtos Naturais, Funchal, Portugal, 26 – 28 July, page
21, 2007.
12. Kairys V., Fernandes M.X.; SitCon: Binding Site Residue Conservation Visualization and Protein
Sequence-to-Function Tool; 2nd Materials Line Meeting/CQM, Funchal, Portugal, January 26th,
2007.
13. Kairys V., Gilson M.K., Fernandes M.X.; Protein-ligand docking with some applications; 9th
International Conference-Scool "Advanced Materials and Technologies”; Palanga, Lithuania,
August 27-31, page 24, 2007.
14. Oliveira L., Caldeira M., Rodrigues F., Perestrelo R., Marques J.C., Câmara J.S.; Evaluation of
the volatile composition of whiskeys by different extraction methods. Identification of the main
odorants; 8º Encontro de Química dos Alimentos, Beja, Março 2007.
15. Pereira V., Pontes M., Paixão N., Câmara J.S., Marques J.C.; Typical volatiles obtained from
model systems simulating the Madeira wines heating; ExTech®2007 Ninth International
Symposium on Advances in Extraction Technologies; Älesund, Norway; June 3-6, page 88, 2007.
16. Pereira, C., Costa, S., Marques, J.C.; Metodologia para a Análise e Controlo de Riscos em
Empresas Industriais de Tratamento de Resíduos Sólidos Urbanos e Equiparados, II Encontro
Nacional de Riscos, Segurança e Fiabilidade; promovido pela European Safety and Reliability
Association, Lisboa, 13-15 de Novembro de 2007.
17. Perestrelo R., Câmara J.S., Nogueira J.N.F.; Development and optimization of a sensitive
method by Stir Bar Sportive Extraction for analysis of fatty acids ethyl esters in wines; In Vino
Analytica Scientia, Melbourne, Australia. July 2007.
18. Rodrigues J.; An Organometallic Approach to Molecular Electronics; FAME - Functionalised
Advanced Materials and Engineering of Hybrids and Ceramics, EU FP6 Network of Excellence,
- 32 -
Funchal, Portugal, September 30-October 5, 2007, (Plenary Talk).
19. Sousa I., Kairys V., Padrón J., Fernandes M.X.; Elucidation of mechanisms of action of molecules
with anti-cancer activity using protein-ligand docking; II Meeting of the Young Biomedical
Investigators of the Macaronesia, Lanzarote, Spain, November 10-13, 2007.
20. Sousa I., Kairys V., Padrón J., Fernandes M.X.; Identification of molecular targets in anti-cancer
therapy using protein-ligand docking; Natural Products Workshop, Funchal, Portugal, July 26-28,
2007.
21. Sousa, J.A., Reynolds, A.P., Delgado, I.S., Marques, J.C., Teixeira, L.M., Jesus, C.G.; Estudo
comparativo de diferentes métodos na avaliação de incertezas de medição em metrologia
química; 2ª Conferência Nacional de Metrologia, Metrologia e Inovação, Funchal, 3-4 Outubro
2007-11-15.
22. Weinhold T., Gouveia S.C., Castilho P.C., Póvoa O.; Composição e bioactividade de óleos
essenciais e extractos de Mentha cervina e Mentha pulegium; Workshop de Produtos Naturais,
Funchal, Portugal, 26 – 28 July, page 24, 2007.
POSTER COMMUNICATIONS
1. Alves C.S., Kairys V., Fernandes, M.X.; Conformational dynamics of the cell-penetrating
peptide, Pep-1, in membrane model systems: a Brownian dynamics simulation; European
Conference on Synthetic Biology; Sant Feliu de Guixols, Spain; November 24-29, 2007.
2. Gomes C., Castilho P.C.; Natural Sources of Shikimic Acid and its Quantification in Pteridium
aquilinum By RP-HPLC-DAD; Phytochemical Society of Europe Young Scientist Meeting, Gargnano,
Italy 6-9 June 2007.
3. Caldeira M., Rodrigues F., Luís C., Perestrelo R., Marques J.C., Câmara J.S.; Identification of
compounds with antioxidant potencial in several plants; V Encontro Nacional de Cromatografia.
Aveiro, Portugal, Dezembro de 2007.
4. Caldeira M., Rodrigues F., Marques J.C., Câmara J.S.; Characterization of the volatile
composition in commercial beers using HS-SPME-GC-qMS; V Encontro Nacional de Cromatografia.
5. Castilho P. C., Gouveia S.; Studies on Artemisia annua essential oils: composition, bioactivity and
safety aspects; 38th International Symposium on Essential Oils (ISEO), Graz, Austria, 9th - 12th
September 2007, page 159.
6. Castilho P.C.; Composition of the volatiles from flowers of Bystropogon maderensis Webb by
SPME; International Congress and 55th Annual Meeting of the Society for Medicinal Plant
Research Graz, Austria, 2nd - 6th September 2007.
7. Coelho E., Perestrelo R., Câmara J.S., Coimbra M.A., Nogueira J.M.F., Rocha S.M.; Optimization
of the stir bar sorptive extraction with liquid desorption for the quantification of volatile
compounds. application to sparkling wines; V Encontro Nacional de Cromatografia. Aveiro,
Portugal; Dezembro de 2007.
8. Czardybon W., Figueira J., Mesquita J., Rodrigues J., Russo L.,, Rissanen K.; Synthesis and
Characterization of a Family of Pd(II) Metallomolecular Wires Based in 1,4-Bis(ethynyl)-2,5bis(alkoxy)benzene Organic Spacers; Trends in Nanoscience 2007; Kloster Irsee, Germany,
February 24-28, P6, 2007.
9. Figueira J., Mesquita J., Rodrigues J., Rissanen K.; New Metallomolecular Wires Based in
Oligothiophene Bridging Systems - A systematic Study; European School on NanoSciences and
Nanotechnologies; Grenoble, France, 26 August - 14 September, 2007.
10. Figueira J., Mesquita J., Rodrigues J., Rissanen K; New OPE and OTE Ruthenium
Metallomolecular Wires; 7ª Conferência de Química Inorgânica; Fátima, Portugal, 30 Novembro-1
- 33 -
de Dezembro, P55, page 87, 2007.
11. Figueira J., Vertlib V., Rodrigues J., K . Nattinen K., Rissanen K.; New Metallomolecular Wires
Based in Oligothiophene Bridging Systems - A systematic Study; NanoScience Days 2007;
Jyvaskyla, Finland, 25-26 October, P32, page A10, 2007.
12. Gouveia S., Camacho E., Weinhold T., Castilho P.C., Luna-Herrera J.; Antimicobacterial and
antioxidant activity of Helichrysum devium Johns. from Madeira Archipelago; International
Congress and 55th Annual Meeting of the Society for Medicinal Plant Research Graz, Austria, 2nd
- 6th September 2007.
13. Gouveia S., Câmara J.S., Castilho P.C.; Solid-phase microextraction of volatile compounds from
Laurobasidium lauri from Madeira Archipelago; 38th International Symposium on Essential Oils.
Graz, Áustria. Setembro 2007.
14. Luís C., Caldeira M., Rodrigues F., Marques J.C., Câmara J.S.; Screening of the volatile profile
in medicinal plants: Mentha piperita and Mentha spicata; V Encontro Nacional de Cromatografia.
15. Luís C., Caldeira M., Rodrigues F., Marques J.C., Câmara J.S.; Screening of the Volatile
Composition of Four Medicinal Plants by HS-SPME-GC-qMS: Thymus Vulgaris, Mentha Spicata,
Mentha Piperita and Rosemary; 31st International Symposium on Capillary Chromatography &
Electrophoresis. Albuquerque, New Mexico USA. November, 2007.
16. Meli A.L., Ngninzeko F.N, Castilho P.C., Wansi J.D., Kuete V., Lontsi D., Beng V.P., Choudhary
M.I., Sondengam B.L.; Securidacaxanthones B and C, xanthones from Securidaca
longepedunculata (Polygalaceae); International Congress and 55th Annual Meeting of the Society
for Medicinal Plant Research Graz, Austria, 2nd - 6th September 2007.
17. Paixão N., Gouveia C., Silva C., Gouveia C., Caboz J., Marques J.C., Câmara J.S.; Comparative
study of polyphenolic contents in several drinks; 8º Encontro de Química dos Alimentos, Beja,
Março, page 321-324, 2007.
18. Paixão N., Pereira V., Marques J.C., Câmara J.S.; Comparative Evaluation of Phenolic
Composition in Red, White and Rosé Wines by RP-HPLC-DAD; 31st International Symposium on
High Performance Liquid Phase Separations and Related Techniques. Ghent, Belgium. June, page
783, 2007.
19. Paixão N., Pereira V., Marques J.C., Câmara J.S.; Determination of Antioxidant Capacity by
different methods. Correlation with Phenolic Content of Madeira Table Wine; In Vino Analytica
Scientia, Melbourne, Australia. July 2007.
20. Paixão N., Pereira V., Marques J.C., Câmara J.S.; Determination of (-)-Epicatechin and TransResveratrol in Madeira Table Wines using HPLC-DAD; 31st International Symposium on High
Performance Liquid Phase Separations and Related Techniques. Ghent, Belgium. June, page 802,
2007.
21. Paixão N., Pereira V., Perez J.P., Marques J.C., Conde J.E., Câmara J.S.; Determination Of
Polyphenols Content In Madeira Table Wines By Rp-Hplc With Diode Array Detection;
ExTech®2007 Ninth International Symposium on Advances in Extraction Technologies, Älesund,
Norway. June, page 182, 2007.
22. Paixão N., Perestrelo R., Pereira V., Marques J.C., Conde J.E., Câmara J.S.; Relationship
between Antioxidant Capacity and Phenolic Content of Madeira Table Wines; 8º Encontro de
Química dos Alimentos, Beja, Março 2007, page 235-238.
23. Pereira A.C., Pontes M., Pereira V., Câmara J.S., Marques J.C.;. Volatile Profile of Madeira
Liquer wines of different harvests; EUROanalysis XIV, Antwerp, Belgium. September, page 510,
2007.
24. Pereira A.C., Pontes M., Pereira V., Câmara J.S., P.M. Saraiva, Marques J.C.; Differentiation
between Wine Varieties from Madeira and Canary Islands; EUROanalysis XIV, Antwerp, Belgium.
- 34 -
September, page 511, 2007.
25. Pereira A.C., Saraiva P.M., Câmara J.S., Reis M.S., Marques J.C.; Multivariate statistical analysis
of major volatiles found in Madeira wines; V Encontro Nacional de Cromatografia. Aveiro,
Portugal, Dezembro de 2007.
26. Pereira V., Pita C., Gonçalves F., Quintal M., Cabral N., Marques J.C., Câmara J.S.;
Determination of (-)-epicatechin and trans-resveratrol in Terras Madeirenses red wines using
HPLC-DAD; V Encontro Nacional de Cromatografia. Aveiro, Portugal, Dezembro de 2007.
27. Pereira V., Pontes M., Câmara J.S., Marques J.C.; Amino Acids and Biogenic Amines in Madeira
Wines Submitted to Estufagem; 31st International Symposium on High Performance Liquid Phase
Separations and Related Techniques. Ghent, Belgium. June, page 786, 2007.
28. Pereira V., Pontes M., Câmara J.S., Marques J.C.; Validation of an HPLC method for the
simultaneous determination of amino acids and biogenic amines. Application to wines and honey
samples; V Encontro Nacional de Cromatografia. Aveiro, Portugal, Dezembro de 2007.
29. Pereira V., Pontes M., Paixão N., Câmara J.S., Marques J.C.; Efeito da Estufagem na Composição
do Vinho Madeira; 8º Encontro de Química dos Alimentos, Beja, Março, page 205-208, 2007.
30. Pereira V., Pontes M., Paixão N., Câmara J.S., Marques J.C.; Evaluation of the phenolic
composition and antioxidant capacity of Madeira Wines submitted to the ageing process
Estufagem; In Vino Analytica Scientia, Melbourne, Australia. July 2007.
31. Perestrelo R., Caldeira M., Rodrigues F., Marques J.C., Câmara J.S.; Dynamic headspace solidphase microextraction gas chromatography- mass spectrometry in the evaluation of the aroma
profile of Enxurros and Rocha Branca wines; In Vino Analytica Scientia, Melbourne, Australia. July
2007.
32. Perestrelo R., Caldeira M., Rodrigues F., Oliveira L., Pereira V., Marques J.C., Câmara J.S.;
Behaviour of volatile composition during the heating process of TNM red wines; 8º Encontro de
Química dos Alimentos, Beja, Março 2007, page 543-546.
33. Perestrelo R., Caldeira M., Rodrigues F., Sousa I., Marques J.C., Câmara J.S.; Characterisation
of the volatile composition of Madeira red wines by dynamic headspace solid-phase
microextraction-gas chromatography-ion trap mass spectrometry; ExTech®2007 Ninth
International Symposium on Advances in Extraction Technologies, Älesund, Norway. June, page
180-181, 2007.
34. Perestrelo R., Caldeira M., Rodrigues F., Sousa I., Marques J.C., Câmara J.S.; Headspace SolidPhase Microextraction as a Tool for Characterisation of Vinho Regional Terras Madeirenses; 6º
Encontro da Divisão de Química Analítica. Lisboa, IST. Março, page 88, 2007.
35. Perestrelo R., Câmara J.S., Nogueira J.M.F.; Characterization of the volatile compounds in
Madeira wines using bar sorptive extraction; V Encontro Nacional de Cromatografia. Aveiro,
Portugal; Dezembro de 2007.
36. Perestrelo R., Coelho E., Rocha S.M., Delgadillo I., Coimbra M.A., Câmara J.S., Nogueira J.M.F.;
Comparison of potentialities of stir bar sorptive extraction and solid-phase microextraction for
quantification of ethyl esters and acetates in wines; 3rd International Symposium on Recent
Advances in Food Analysis. Prague, República Checa, page 369, November 2007.
37. Perestrelo R., Luís C., Caldeira M., Rodrigues F., Marques J.C., Câmara J.S.; Estimation of
phenolic compounds and volatile composition of Ruta Chalepensis; V Encontro Nacional de
Cromatografia. Aveiro, Portugal, Dezembro de 2007.
38. Perestrelo R., Luís C., Caldeira M., Rodrigues F., Marques J.C., Câmara J.S.; Characterization of
Madeira Island endemic medicinal plant Ruta Chalepensis by HS-SPME-GC-qMS, HPLC-DAD and UVVIS; 31st International Symposium on Capillary Chromatography & Electrophoresis. Albuquerque,
New Mexico USA. November, 2007.
- 35 -
39. Pontes M., Marques J.C., Câmara J.S.; Dynamic headspace solid-phase microextraction-gas
chromatography–quadrupole masss spectrometry analysis of the volatile compounds in Dwarf
Cavendish banana; 31st International Symposium on Capillary Chromatography & Electrophoresis.
Albuquerque, New Mexico USA. November, 2007.
40. Pontes M., Marques J.C., Câmara J.S.; Evaluation of the volatile composition of honey by solidphase microextraction and gas chromatography-mass spectrometry; V Encontro Nacional de
Cromatografia. Aveiro, Portugal, Dezembro de 2007.
41. Pontes M., Marques J.C., Câmara J.S.; Screening of honey volatile compounds by HS-SPME/GCqMS; ExTech®2007 Ninth International Symposium on Advances in Extraction Technologies,
Älesund, Norway. June, page 183, 2007.
42. Pontes M., Paixão N., Marques J.C., Câmara J.S.; Determination of Total Phenolic, Flavonoids
and antioxidant capacity of Portuguese Honeys; EUROanalysis XIV, Antwerp, Belgium. September,
page 442, 2007.
43. Pontes M., Paixão N., Marques J.C., Câmara J.S.; The Contribution of SPME in the
differentiation of Passion Fruit species; EUROanalysis XIV, Antwerp, Belgium. September, page
514, 2007.
44. Pontes M., Pereira V., Albuquerque F., Câmara J.S., Ferreira A.C.S., Marques J.C.; Evolution of
Free Amino Acids in Young Madeira Wines Submited to Controled Heating Conditions; ŒNO 2007,
8th International Enology Symposium, Bordeaux, France. June, 2007.
45. Pontes M., Pereira V., Marques J.C., Câmara J.S.; Evaluation of Amino Acids and Biogenic
Amines content in Portuguese Honeys by RP-HPLC with fluorescence detection; 31st International
Symposium on High Performance Liquid Phase Separations and Related Techniques. Ghent,
Belgium. June, page 784, 2007.
46. Rosenberger M., Pereira V., Câmara J.S., Marques J.C.; Optimisation of the Extraction
Procedure Used for the Determination of Ethyl Carbamate in Madeira Wines; 8º Encontro de
Química dos Alimentos, Beja, Março, page 487-490, 2007.
47. Santos J.L., Oliveira, H., Oramas E.G., Pego A.P., Granja P.L., Tomás H; Gene Therapy Platform
For Bone Regeneration Using Dendrimers and Osteogenic Plasmids Systems; Gordon Research
Conference-BIOMATERIALS: BIOCOMPATIBILITY/TISSUE ENGINEERING, Holderness School,
Holderness, NH , USA; 22-27 July, 2007.
48. Santos J.L., Oramas E.G., Pego A.P., Granja P.L., Tomás H.; In vitro gene delivery studies using
polyamidoamine dendrimers: physicochemical characterization of dendriplexes and transfection
efficiency evaluation; 3rd Marie Curie Cutting Edge InVENTS Conference, Funchal, Portugal; 4-8
June, 2007.
49. Santos J.L., Oramas E.G., Pego A.P., Granja P.L., Tomás H.; Polyamidoamine Dendrimer vectors
for gene delivery: physicochemical characterization and transfection efficiency evaluation; 8th
Advanced Summer Course in Cell Materials-Interactions; Instituto de Engenharia Biomédica,
Porto, Portugal; 18-22 June, 2007.
50. Weinhold T. S., Gouveia S. C., Castilho P. C., O. Póvoa; Evaluation of the free radical scavenging
capacity (RSC) of extracts and essential oils from Mentha cervina and Mentha pulegium;
Phytochemical Society of Europe Young Scientist Meeting, Gargnano, Italy 6-9 June 2007.
SCIENCE DIVULGATION COMMUNICATIONS
1. Tomás, H.; A Química é Divertida, Doze anos de promoção da Química na Madeira; Química
(Boletim da Sociedade Portuguesa de Química); 104, 51-52, 2007.
POPULAR PRESS ARTICLES AND NEWSPAPER INTERVIEWS
- 36 -
1. Fernandes C.; Argilas de Porto Santo Valorizadas; in Diário de Notícias (Madeira). Newspaper
interview. 15 of July 2007.
7. Funding
Since its creation in 2004, CQM had the support of several institutions (see main supporters). FCT was
one of the most important supporters with CQM receiving a budget proportional to the classification
obtained in the previous evaluation and to the number of Ph.D. members (Pluri-annual Programme:
€36.457 in 2007).
From 2004 until the end of 2007, including: national projects funded by FCT, AdI and other financial
sources; international projects in the scope of the program INTERREG IIIB; FCT grants and pluri-annual
Programme, the CQM budget totalised a value ca. of €3.271.000 (a total amount that considers the
budget of all partners involved), besides its involvement in the two national networks of NMR and MS
(that correspond to a total budget of €9.800.000). From these amounts (that includes the Pluri-annual
Programme), about €2.484.000 were directly managed by CQM members and applied in UMa research
activities.
From Figure 4, which shows the distribution of CQM financial resources by source in the period 20042007, we can conclude that the income managed by CQM came mainly from FCT (Human Resources, reequipment projects, national projects and Pluri-annual programme) with a percentage of 76%. Even if,
during the period 2004-2007, the support received through the Pluri-annual Programme only represents
ca. 3% of the total budget managed by CQM, this support was undoubtedly fundamental for the normal
running of research activities.
Figure 4. Distribution of CQM funding by source, from 2004 till the end of 2007 (amount
managed by CQM only).
- 37 -
8. Main supporters
The research unit receives financial support from:
Other supports:
- 38 -
9. Annexes
- 39 -
3º Encontro Anual
Linha de Materiais
http://cqm.uma.pt 10:30h‐16.30h, 25 Janeiro 2008 Edifício da Penteada, Anf 6 9000‐390 Funchal Os investigadores da Linha de Materiais do CQM apre‐
sentarão os avanços mais recentes dos projectos de in‐
vestigação em curso, nas áreas de Nanomateriais para aplicações Biomédicas e Optoelectrónicas e Design de Fármacos. Incentivamos especialmente a participação dos alunos de Química e Bioquímica. O número de participantes é limitado e a inscrição é obrigatória. Informação e inscrições
E-mail: [email protected]
Fax: 291 705 149
Web: http://cqm.uma.pt
Apoios
JORNADAS DO PROJECTO
ANTIVINMAC
Determinação do potencial antioxidante,
aminoácidos e aminas biogénicas em vinhos de
ANTIVINMAC
castas comuns a Canárias, Açores e Madeira
05/MAC/2.3/M28
PROGRAMA
1 DE FEVEREIRO
Piso - 2
2 DE FEVEREIRO
Sala Senado
Universidade da Madeira – Campus Universitário da Penteada
1, 2 e 3 de FEVEREIRO de 2007
Reunião Geral do Projecto ANTIVINMAC
9:30 Sessão de abertura
Presenç
Presença do presidente do IVBTAM (Eng. Paulo Rodrigues) e Dr. Carlos
Estudante (Gestor Regional do INTERREG)
9:45 José
José Câmara
10:00 Juan Jesus
10:30 Sílvia Rocha
Apresentaç
Apresentação do Projecto Antivinmac
Trazabilidad en la industria vitiviní
vitivinícola
O potencial enoló
enológico e bioló
biológico da Vitis vinifera L.
11:00 Coffee Break
11:15 Juan Pedro
11:45 Francisco Albuquerque
Aminas bió
biógenas en vinos
A importância da enologia nos Vinhos Madeira
12:10 Vanda Pereira
Aná
Análise e ciné
cinética de formaç
formação do 55-hidroximetilfurfural nos Vinho Madeira
14:30 José
José C. Marques
Valorizar o Vinho Madeira pela investigaç
investigação
14:45 José
José Elias
Aplicaciones prá
prácticas del aná
análisis de pará
parámetros no convencionales en vinos
15:15 Carlota Ferreira
15:45 Maria Álvares
16:15 Neuza Paixão
Vitivinicultura na Madeira
O ressurgimento da vitivinicultura na ilha do Pico
Avaliaç
Avaliação do teor de polifenó
polifenóis nos vinhos de Mesa Terras Madeirenses e nos
vinhos de Caná
Canárias
16:30 Coffe Break
16:45 Paula Castilho
Extracç
Extracção e caracterizaç
caracterização de subprodutos da grainha de uva: óleo vegetal e
polifenó
polifenóis
17:10 Michael Murkovic
Polyphenols in Foods
18:00 Prova de Vinhos Madeira Açores e Caná
Canárias
3 DE FEVEREIRO
APOIOS
Visita Guiada a Produtores de Vinho Madeira
IVBAM

Relatório de Actividades 2007 - Centro de Química da Madeira

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