Vaccyn: Extrato Padronizado em 20% de Antocianidinas

1. Geriatria
2. Ortomolecular
Agosto/Setembro de 2012
3. Nutrição/Nutrologia
Vaccyn: Extrato Padronizado em 20% de
Antocianidinas
Bilberry + Blueberry + Cranberry
Potente Ação Antioxidante Para Melhora da Visão, Memória e
Aparência da Pele do Idoso
02 Vaccyn
02 Definição, Propriedades, Doses e Posologia, Indicações, Reações Adversas e Contraindicações
03 Vaccyn: Bilberry + Blueberry + Cranberry
05 Indicações Terapêuticas Baseadas em Evidências: Tratamentos Nutracêuticos Para a Saúde Cutânea e
Ocular do Idoso
06 Indicações Terapêuticas Baseadas em Evidências: Suplementação Complementar Para a Melhora do
Desempenho Cognitivo do Idoso
07 Indicações Terapêuticas Baseadas em Evidências: Nutracêuticos Auxiliares na Saúde dos Sistemas
Cardiovascular e Metabólico em Idosos
Lançamento: Novo Extrato Padronizado em 20% de Antocianidinas Promotor da
Saúde Geral e da Pele do Idoso
Propriedade Antioxidante Potente Para Melhora da Visão, Memória e Aparência da Pele
Formulários Exclusivos de Nutracêuticos Auxiliares na Saúde dos Idosos
Vaccyn
Definição, Propriedades, Doses e Posologia, Indicações, Reações
Adversas e Contraindicações
Definição
Vaccyn é um extrato padronizado em 20% antocianidinas, composto pelos
extratos de três tipos de berries do gênero Vaccinium: Bilberry (Vaccinium
myrtillus), Blueberry (Vaccinium corymbosium) e Cranberry (Vaccinium
macrocarpon).
Propriedades
O gênero Vaccinium é um gênero que inclui diversos frutos comestíveis
(exemplo: cranberry, bilberry e blueberry), cujo consumo tem sido associado a
diversos efeitos benéficos para a saúde. Estudos mostram que uma série de
compostos funcionais foram extraídos dos frutos e sementes das plantas do
gênero Vaccinium, sendo que as antocianidinas, seu principal constituinte,
possui propriedades antioxidante, antimicrobiana e anti-inflamatória.
Johnson BJ, Lin B, Bongard JE. Genus vaccinium: medicine, cosmetics, and coatings. Recent Pat
Biotechnol. 2010 Jun 1;4(2):112-24.
Doses e Posologia
A dose usual de Vaccyn é de 1 g ao dia. Estudos também mostram o uso da
dose de antocianidinas de 20 a 40 mg, três vezes ao dia.
[No authors listed] Monograph. Vaccinium myrtillus (bilberry). Altern Med Rev. 2001 Oct;6(5):500-4.
Indicações
As antocianidinas têm sido indicadas como suplemento:
• Antioxidante geral para idosos (visão, pele e memória);
• Melhora da vasodilatação endotélio-dependente em
hipercolesterolêmicos;
• Melhora do perfil lipídico;
• Redução da inflamação;
• Redução de infecções do trato urinário.
indivíduos
Zhu Y, Xia M, Yang Y, Liu F, Li Z, Hao Y, Mi M, Jin T, Ling W. Purified anthocyanin supplementation
improves endothelial function via NO-cGMP activation in hypercholesterolemic individuals. Clin
Chem. 2011 Nov;57(11):1524-33. doi: 10.1373/clinchem.2011.167361. Epub 2011 Sep 16.
Pérez-López FR, Haya J, Chedraui P. Vaccinium macrocarpon: An interesting option for women with
recurrent urinary tract infections and other health benefits. J Obstet Gynaecol Res. 2009
Aug;35(4):630-9.
Reações Adversas e Contraindicações
Extratos de bilberry e de outros berries do gênero Vaccinium possuem
propriedades antiagregação plaquetária, e doses muito altas devem ser
usadas com precaução em pacientes com distúrbios hemorrágicos ou que
estiverem utilizando anticoagulantes ou antiplaquetários.
[No authors listed] Monograph. Vaccinium myrtillus (bilberry). Altern Med Rev. 2001 Oct;6(5):500-4.
Vaccyn: Bilberry + Blueberry + Cranberry
Indicação Terapêutica
Vaccyn ____________________ 500 mg
Duas cápsulas ao dia, sendo uma pela manhã e
uma à tarde.
Saúde do Idoso
Bilberry: Ação Antioxidante Para Saúde Cutânea e
Ocular
Vaccinium myrtillus (Bilberry) é um membro da família
Ericaceae
rico
em
flavonóides
antocianosídeos
(antocianinas).
•
Extratos de Bilberry contendo antocianosídeos têm
demonstrado fortes propriedades:
• Antioxidante,
• Estabilizante de fibras de colágeno,
• Promotoras da biossíntese de colágeno,
• Diminui a permeabilidade e fragilidade capilar,
• Inibe agregação plaquetária,
Impede a liberação e síntese de compostos pró-inflamatórios como a
histamina, prostaglandinas e leucotrienos.
[No authors listed] Monograph. Vaccinium myrtillus (bilberry). Altern Med Rev. 2001 Oct;6(5):500-4.
Blueberry: Polifenois Neuroprotetores Para Melhora
da Cognição em Idosos
Os principais componentes do blueberry (Vaccinium
corymbosium) são as antocianinas e o ácido clorogênico,
entre outros. Apresenta atividade de neuroproteção,
impedindo as mudanças relacionadas à idade, bem como
melhora a cognição em idosos.
Yang H, Jiang Y. Research progress of bioactive constituents,
absorption, metabolism, and neuroprotective effects from blueberry. Wei
Sheng Yan Jiu. 2010 Jul;39(4):525-8.
Blueberry possui alto conteúdo de polifenois, os quais
podem ser úteis como agentes farmacológicos em várias doenças
neurológicas, pois apresentam efeitos favoráveis relacionados à
neuroproteção e redução do declínio cognitivo relacionado à idade.
Giacalone M, Di Sacco F, Traupe I, Topini R, Forfori F, Giunta F. Antioxidant and neuroprotective
properties of blueberry polyphenols: a critical review. Nutr Neurosci. 2011 May;14(3):119-25.
Cranberry: Benefícios Para o Trato Urinário e
Sistemas Cardiovascular e Metabólico
Cranberry (Vaccinium macrocarpon) já se mostra
como uma opção eficaz e muito utilizada no
tratamento de infecção recorrente do trato urinário
em mulheres bem como outras condições de saúde.
Estudos sugerem que os componentes do cranberry
podem ter benefícios potenciais, incluindo efeitos
anti-infeccioso, anticancerígeno e antioxidante,
que podem ser considerados positivos para
diferentes condições relacionadas à idade. Além
disso, os componentes do cranberry podem induzir
mudanças positivas cardiovasculares e metabólicas, e podem melhorar a
atividade neuropsicológica.
Pérez-López FR, Haya J, Chedraui P. Vaccinium macrocarpon: An interesting option for women with
recurrent urinary tract infections and other health benefits. J Obstet Gynaecol Res. 2009
Aug;35(4):630-9.
Indicações Terapêuticas Baseadas em Evidências
Tratamentos Nutracêuticos Para a Saúde Cutânea e Ocular do
Idoso
Isoflavonas da soja 100% _____ 100 mg
Efeito Antirrugas em Mulheres PósTomar uma cápsula ao dia após o café
Menopausadas
da manhã.
O tratamento com 100 mg de isoflavonas da soja resultou em um aumento de
9,46% na espessura da epiderme. A quantidade de colágeno na derme foi
aumentada (86,2%), assim como o número de fibras elásticas (75,8%). O
número de vasos sanguíneos da derme também aumentou significativamente.
Accorsi-Neto A, Haidar M, Simões R, Simões M, Soares-Jr J, Baracat E. Effects of isoflavones on the
skin of postmenopausal women: a pilot study. Clinics (Sao Paulo). 2009;64(6):505-10.
Coenzima Q10 ______________ 50 mg
Prevenção do Envelhecimento
Vitamina E _________________ 50 mg
Cutâneo Com Antioxidantes
Selênio ___________________ 50 mcg
Dose diária administrada junto com uma
das principais refeições.
O tratamento oral diário com 50 mg de CoQ10 + 50 mg de Vitamina E + 50 mcg
de Selênio aumenta os níveis destes antioxidantes no estrato córneo e no
plasma, retardando o processo de envelhecimento da pele.
Passi S, De Pità O, Grandinetti M, Simotti C, Littarru GP. The combined use of oral and topical
lipophilic antioxidants increases their levels both in sebum and stratum corneum. Biofactors.
2003;18(1-4):289-97.
Luteína _______________________ 10 mg
Melhora da Visão em
Dose diária administrada junto a uma das
Pacientes com Degeneração
refeições.
Macular Relacionada à Idade
Um estudo mostrou que a luteína 10 mg/dia promove aumento da densidade
do pigmento óptico macular em pacientes com degeneração macular
relacionada à idade.
Richer S, Devenport J, Lang JC. LAST II: Differential temporal responses of macular pigment optical
density in patients with atrophic age-related macular degeneration to dietary supplementation with
xanthophylls. Optometry. 2007 May;78(5):213-9.
Indicações Terapêuticas Baseadas em Evidências
Suplementação Complementar Para a Melhora do Desempenho
Cognitivo do Idoso
Picolinato de Cromo ___________ 1.000 mcg
Melhora do Desempenho
Dose diária administrada junto ou não de uma
Cognitivo e da Função
das refeições.
Cerebral
Resultados sugerem que a suplementação com picolinato de cromo, 1.000 mcg
por dia durante 12 semanas, pode melhorar o desempenho cognitivo e a
função cerebral em idosos com risco neurodegenerativo.
Krikorian R, Eliassen JC, Boespflug EL, Nash TA, Shidler MD. Improved cognitive-cerebral function in
older adults with chromium supplementation. Nutr Neurosci. 2010 Jun;13(3):116-22.
Idebenona _______________________120 mg Tratamento da Demência e
Dose diária administrada junto ou não de uma
Perda Parcial de Memória
das refeições.
Sem Demência
A idebenona na dose diária de 120 mg, por seis meses, demonstrou melhora a
curto e longo prazo na memória e na atenção, com melhora na dicção, em
testes dinâmicos, visuais, de imaginação e na escrita de pacientes com
demência do tipo Alzheimer, demência mista e lapsos de memória não
relacionados à demência.
Voronkova KV, Meleshkov MN. Use of Noben (idebenone) in the treatment of dementia and memory
impairments without dementia. Neurosci Behav Physiol. 2009 Jun;39(5):501-6.
Creatina___________________________5 g
Pó Para Suspensão Extemporânea com Whey
Protein (aroma Shake de chocolate_______ 10 g
Melhora do Desempenho
Dissolver o conteúdo de um sachê em 200 ml de
Cognitivo em Idosos
água ou leite desnatado, agitar vigorosamente e
ingerir em seguida.
Administrar 4 vezes ao dia.
Um estudo mostrou que a suplementação de creatina (20 g ao dia) auxilia
na cognição em idosos, com efeitos significativos da suplementação de
creatina em todos os testes de memória avaliados.
McMorris T, Mielcarz G, Harris RC, Swain JP, Howard A. Creatine supplementation and cognitive
performance in elderly individuals. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2007
Sep;14(5):517-28.
Indicações Terapêuticas Baseadas em Evidências
Nutracêuticos Auxiliares na Saúde dos Sistemas Cardiovascular
e Metabólico em Idosos
Pycnogenol (Pinnus
Redução da Hipertensão e
pinaster)_______________125 mg
Outros Fatores de Risco
Cardiovascular
Dose diária administrada longe das
refeições.
Após 12 semanas de suplementação, Pycnogenol (125 mg/dia) resultou em
uma melhora no controle do diabetes, baixou os fatores de risco
cardiovascular, além de reduzir o uso de medicamento anti-hipertensivo
quando comparado ao placebo.
Zibadi S, Rohdewald PJ, Park D, Watson RR. Reduction of cardiovascular risk factors in subjects
with type 2 diabetes by Pycnogenol supplementation. Nutr Res. 2008 May;28(5):315-20.
Extrato de Pomegrante (Punica
Redução dos Fatores de Risco
granatum)___________1.000 mg
Cardiovascular em Indivíduos
Dose diária administrada após o café da
Sobrepesados
manhã.
A dose de 1.000 mg ao dia do extrato de Pomegranate reduziu de forma
significativa os níveis de TBARS, que foi correlacionado com a redução do
risco cardiovascular em indivíduos com sobrepeso.
Heber D, Seeram NP, Wyatt H, Henning SM, Zhang Y, Ogden LG, Dreher M, Hill JO. Safety and
antioxidant activity of a pomegranate ellagitannin-enriched polyphenol dietary supplement in
overweight individuals with increased waist size. J Agric Food Chem. 2007 Nov 28;55(24):10050-4.
Epub 2007 Oct 30.
Referências Bibliográficas
Zibadi S, Rohdewald PJ, Park D, Watson RR. Reduction of cardiovascular risk
factors in subjects with type 2 diabetes by Pycnogenol supplementation. Nutr
Res. 2008 May;28(5):315-20.
Heber D, Seeram NP, Wyatt H, Henning SM, Zhang Y, Ogden LG, Dreher M, Hill JO.
Safety and antioxidant activity of a pomegranate ellagitannin-enriched
polyphenol dietary supplement in overweight individuals with increased waist
size. J Agric Food Chem. 2007 Nov 28;55(24):10050-4. Epub 2007 Oct 30.
McMorris T, Mielcarz G, Harris RC, Swain JP, Howard A. Creatine supplementation
and cognitive performance in elderly individuals. Neuropsychol Dev Cogn B Aging
Neuropsychol Cogn. 2007 Sep;14(5):517-28.
Voronkova KV, Meleshkov MN. Use of Noben (idebenone) in the treatment of
dementia and memory impairments without dementia. Neurosci Behav Physiol.
2009 Jun;39(5):501-6.
Krikorian R, Eliassen JC, Boespflug EL, Nash TA, Shidler MD. Improved cognitivecerebral function in older adults with chromium supplementation. Nutr Neurosci.
2010 Jun;13(3):116-22.
Apoio Farmacotécnico
Shake Base
Pó para Suspensão Extemporânea com Whey Protein
Fase
Componentes
Função
A
Whey Protein
Veículo
18,0 g
A
Carboximetilcelulose (CMC)
Espessante
0,30 g
A
Lecitina de Soja (pó)
Emulsificante
0,15 g
®
Quantidades
para 1 sachê **
A
Dióxido de Silício Coloidal (Aerosil 200 )
Antiumectante
0,25 g
A
Sucralose
Edulcorante
0,10 g
A
Acessulfame K
Edulcorante
0,10 g
A
Benzoato de Sódio
Conservante
0,30 g
A
Aroma (pó)
Flavorizante
1,0 g
A
Corante (pó) Opcional
Corante
0,01 g
B
Nutriente funcional
Ingrediente Ativo
(x) mg
Total
~ 20 g
Modo de Preparo
Etapa-1: Triturar, tamisar e misturar geometricamente os pós em ambiente
com umidade relativa controlada FASE A;
Etapa-2: Pesar a quantidade de pó para cada dose, acondicionar em sachê de
tamanho adequado e selar;
Etapa-3: Acondicionar os sachês em caixas cartonadas e rotular.
Abstracts
Clin Chem. 2011 Nov;57(11):1524-33. doi: 10.1373/clinchem.2011.167361.
Epub 2011 Sep 16.
Purified anthocyanin supplementation improves endothelial function via
NO-cGMP activation in hypercholesterolemic individuals.
Zhu Y, Xia M, Yang Y, Liu F, Li Z, Hao Y, Mi M, Jin T, Ling W.
SourceGuangdong Provincial Key Laboratory of Food, Nutrition, and Health,
School of Public Health,SunYat-Sen University (Northern Campus),
Guangzhou, China.
Abstract
BACKGROUND: Anthocyanins have been shown to improve endothelial
function in animal models. However, whether these compounds have similar
beneficial effects in humans is largely unknown.
METHODS: In a short-term crossover study, 12 hypercholesterolemic
individuals were given oral anthocyanins (320 mg) isolated from berries or
placebo. Brachial artery flow-mediated dilation (FMD) was assessed before and
after the intervention. In a long-term intervention trial (12 weeks), 150
hypercholesterolemic individuals were given anthocyanins (320 mg/day, n = 75)
or placebo (n = 75), after which we measured FMD, plasma cGMP, and other
serum biomarkers. Another short-term intervention was conducted in the
presence of NO-cGMP inhibitors in 6 people and in a rat aortic ring model (n =
8).
RESULTS: Significant increases of FMD from 8.3% (0.6%) at baseline to 11.0%
(0.8%) at 1 h and 10.1% (0.9%) at 2 h were observed after short-term
anthocyanin consumption, concomitantly with increases of plasma anthocyanin
concentrations (P < 0.05). In the study participants who received long-term
anthocyanin intervention, compared with the control group, we observed
significant increases in the FMD (28.4% vs 2.2%), cGMP (12.6% vs -1.2%), and
HDL-cholesterol concentrations, but decreases in the serum soluble vascular
adhesion molecule-1 and LDL cholesterol concentrations (P < 0.05). The
changes in the cGMP and HDL cholesterol concentrations positively correlated
with FMD in the anthocyanin group (P < 0.05). In the presence of NO-cGMP
inhibitors, the effects of anthocyanin on endothelial function were abolished in
human participants and in a rat aortic ring model.
CONCLUSIONS: Anthocyanin supplementation improves endotheliumdependent vasodilation in hypercholesterolemic individuals. This effect involves
activation of the NO-cGMP signaling pathway, improvements in the serum lipid
profile, and decreased inflammation.
PMID:21926181[PubMed - indexed for MEDLINE]
Recent Pat Biotechnol. 2010 Jun;4(2):112-24.
Genus vaccinium: medicine, cosmetics, and coatings.
Johnson BJ, Lin B, Bongard JE.
SourceCenter for Bio/Molecular Science and Engineering, Code 6900, Naval
Research Laboratory, Washington, DC 20375, USA. [email protected]
Abstract
Vaccinium is a genus of shrubs several of which, including cranberry,
lingonberry, and blueberry, produce edible fruit. Consumption of the fruit of
these plants and juices pressed from it has long been known to have healthful
effects. A number of functional compounds have been extracted from the fruits
and seeds of these plants. Anthocyanidins and related compounds have been
reported to possess antimicrobial, antioxidant, and anti-inflammatory properties.
Extracts of the fruits have been applied to the inhibition of non-enzymatic
glycosylation in anti-aging preparations. The oil of the cranberry seed is high in
antioxidants and is a source of omega-3, -6, and -9 fatty acids making it an
attractive cosmetics component. The inhibition of tumor growth, angiogenesis,
and metastasis by extracts of these fruits has been described. Extracts of the
plants have also been applied to the development of antimicrobial paints and
coatings. Here, we provide an overview of the wide range of applications
described for various compounds from and preparations of these plants and
survey the recent patents related to those applications.
PMID:20156133[PubMed - indexed for MEDLINE]
Nutr Neurosci. 2011 May;14(3):119-25.
Antioxidant and neuroprotective properties of blueberry polyphenols: a
critical review.
Giacalone M, Di Sacco F, Traupe I, Topini R, Forfori F, Giunta F.
SourceIntensive Care Unit, Department of Surgery, University of Pisa, Pisa,
Italy.
Abstract
OBJECTIVE: The aim of this work was to highlight the effects and the possible
mechanisms of the action of blueberry polyphenols on the central nervous
system (CNS).
METHODS: An analysis was carried out, in a temporal order, of the most
important literature about this topic and the results have been correlated with
the beneficial and protective effects, mainly concerning the CNS.
DISCUSSION: Over the last 10 years an increasing scientific interest has
developed about polyphenols, which are very abundant in blueberries, as they
have been seen to produce favourable effects related to neuroprotection and
linked to a possible decrease of age-related cognitive and motor decline, as
shown by the improvement of such functions in animal models with a
supplemented diet. Such effects could not only be explained through a purely
antioxidant action but also through more complex mechanisms related to
inflammation, genic expression, and regulation of cell survival.
CONCLUSIONS: Despite the wealth of data from animal studies, there is a
relative lack of data concerning human beings, even if some positive results are
beginning to emerge. Therefore, blueberry polyphenols could become useful
pharmacological agents for various conditions including neurological diseases,
but further studies are still necessary to attain this objective.
PMID:21756533[PubMed - indexed for MEDLINE]
Wei Sheng Yan Jiu. 2010 Jul;39(4):525-8.
[Research progress of bioactive constituents, absorption, metabolism,
and neuroprotective effects from blueberry].
[Article in Chinese]
Yang H, Jiang Y.
SourceDepartment of Nutrition and Food Science, Institute of Hygiene and
Environmental Medicine, Tianjin 300050, China. [email protected]
Abstract
The main components of blueberry were anthocyanins, chlorogenic acid, citric
acid, arbutin, myricetin and its glycoside and so on. It has the activities of
neuroprotection, preventing the age-related changes of brain, cardiotonic
activity, etc. Recently, the effects of blueberry extracts on the improve function
of cognition has been attracted wide attention. This review summarizes the
active components, absorption and metabolism of blueberry, especially focuses
on neuroprotection and the mechanisms involved.
PMID:20726253[PubMed - in process]
J Obstet Gynaecol Res. 2009 Aug;35(4):630-9.
Vaccinium macrocarpon: an interesting option for women with recurrent
urinary tract infections and other health benefits.
Pérez-López FR, Haya J, Chedraui P.
SourceDepartment of Obstetrics and Gynecology, University of Zaragoza
Faculty of Medicine, Clínico Universitario de Zaragoza Hospital, Zaragoza,
Spain. [email protected]
Abstract
AIM: To review the scientific publications concerning the clinical use and
mechanism of action of the North American cranberry (Vaccinium macrocarpon)
for women with recurrent urinary tract infections (UTI) and other health
conditions.
METHODS: This is a retrospective study of published information concerning
Vaccinium macrocarpon retrieved from a PubMed and individual searches.
RESULTS: Urinary tract infections are very common in women, cause
discomfort, and may aggravate other genitourinary conditions. The available
scientific information supports a clinical benefit of Vaccinium macrocarpon in the
prevention of recurrent UTI in women. There is a non-significant reduction of
UTI associated with Vaccinium macrocarpon treatment during pregnancy. A
group of proanthocyanidins (PAC) with A-type linkages have been isolated from
Vaccinium macrocarpon which inhibit P-fimbriae synthesis and induce a
bacterial deformation, on both antibiotic-susceptible and antibiotic-resistant
uropathogenic Escherichia coli. It is plausible that cranberry PAC prevent
bacteria from adhering to the uroepithelium of the bladder, thereby blocking the
ability of E. coli to infect the urinary mucosa.
CONCLUSION: Cranberry treatment is a safe, well-tolerated supplement that
does not have significant drug interactions. Although investigations are in the
early stages, experimental and preclinical studies suggest that cranberry
components may have other potential benefits, including anti-infective,
anticancer and antioxidant effects, which may be considered as positive for
different age-related conditions. In addition, cranberry components may induce
positive cardiovascular and metabolic changes, and may improve
neuropsychological activity. These effects warrant further clinical research to
better place the role of cranberry products for women.
PMID:19751320[PubMed - indexed for MEDLINE]
Optometry. 2007 May;78(5):213-9.
LAST II: Differential temporal responses of macular pigment optical
density in patients with atrophic age-related macular degeneration to
dietary supplementation with xanthophylls.
Richer S, Devenport J, Lang JC.
SourceDepartment of Veterans Affairs, Medical Center Eye Clinic, North
Chicago, Illinois 60064-3095, USA. [email protected]
Abstract
BACKGROUND: Age-related macular degeneration (ARMD) is the leading
cause of vision loss in aging Western societies. The objective of the Lutein
Antioxidant Supplementation Trial (LAST) was to determine whether specific
dietary interventions increased macular pigment optical density (MPOD) and
visual function in patients with atrophic ARMD. The current objective of LAST II
is to discern those specific characteristics that increase MPOD, i.e., that might
differentiate a responder from a nonresponder.
METHODS: The LAST study was a prospective, 12-month, randomized,
double-masked, placebo-controlled trial conducted at an urban midwestern
Veterans Administation Hospital from August 1999 to May 2001. Ninety patients
with atrophic ARMD entered the study and were assigned randomly to 1 of 3
groups. Patients in group 1 received 10 mg lutein; in group 2, 10 mg lutein in
combination with vitamins, minerals, and antioxidants; and in group 3,
maltodextrin placebo. Changes in macular MPOD over time were evaluated.
Characteristics potentially influencing MPOD included age, weight (body mass
index), initial baseline values of macular pigment, and combining xanthophylls
with other nutrients.
RESULTS: MPOD increased with supplementation and declined slightly without
supplementation (regression slopes not equal to zero in supplemented groups,
P < 0.02). The highest increases in MPOD over time occurred in patients with
lower baseline values of MPOD. Statistically significant increases in MPOD
density were observed in the lutein group for patients with baseline MPOD
<or=0.3 optical density units and up to 0.2 optical density units in the lutein plus
antioxidant group. Further analysis found that none of the subjects' eyes in the
lowest quartile of baseline MPOD were in the lowest quartile for change in
MPOD.
CONCLUSION: Noteworthy is the observation that those individuals with lowest
MPOD, and in greatest need of supplementation, were also most likely to
benefit from either the lutein or the lutein plus antioxidant supplementation. For
those individuals who responded to supplementation, their macular pigment
optical density had not ceased to increase at 12 months' duration of
supplementation. The inference is that if a deficiency in macular pigment optical
density is accurately diagnosed, effective interventions should be able to reestablish this prophylactic barrier.
PMID:17478338[PubMed - indexed for MEDLINE]
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2007 Sep;14(5):517-28.
Creatine supplementation and cognitive performance in elderly
individuals.
McMorris T, Mielcarz G, Harris RC, Swain JP, Howard A.
SourceSchool of Sport, Exercise and Health Sciences, University of Chichester,
College Lane, Chichester, West Sussex PO19 6PE, UK. [email protected]
Abstract
The purpose of this study was to examine the effect of creatine supplementation
on the cognitive performance of elderly people. Participants were divided into
two groups, which were tested on random number generation, forward and
backward number and spatial recall, and long-term memory tasks to establish a
baseline level. Group 1 (n = 15) were given 5 g four times a day of placebo for 1
week, followed by the same dosage of creatine for the second week. Group 2 (n
= 17) were given placebo both weeks. Participants were retested at the end of
each week. Results showed a significant effect of creatine supplementation on
all tasks except backward number recall. It was concluded that creatine
supplementation aids cognition in the elderly.
PMID:17828627[PubMed - indexed for MEDLINE]
Neurosci Behav Physiol. 2009 Jun;39(5):501-6.
Use of Noben (idebenone) in the treatment of dementia and memory
impairments without dementia.
Voronkova KV, Meleshkov MN.
SourceDepartment of Neurology and Neurosurgery, Russian State Medical
University, Moscow, Russia.
Abstract
Noben (idebenone) at a dose of 120 mg per day for six months was used in the
treatment of 35 patients aged 60-86 years with Alzheimer's-type dementia,
mixed dementia, and memory impairments not reaching the stage of dementia.
Patients were assessed on the basis of data from somatic, neurological, and
psychiatric investigations, as well as neuropsychological testing and a series of
psychometric and other scales and tests, before and after treatment. Significant
improvements in patients' conditions on the MMSE were seen in patients with
mild and moderate dementia. Improvements in daily activities were obtained in
27%
of
patients.
Neuropsychological
investigations
demonstrated
improvements in short-term and long-term memory and attention, with
improvements in speech functions, performance of kinesthetic, spatial, and
dynamic praxis tests, and in visuospatial gnosis, thought, and writing. On the
CGI scale, positive treatment effects were obtained in 37% of patients, while
48% of patients remained in a stable state.
PMID:19430983[PubMed - indexed for MEDLINE]
Clinics (Sao Paulo). 2009;64(6):505-10.
Effects of isoflavones on the skin of postmenopausal women: a pilot
study.
Accorsi-Neto A, Haidar M, Simões R, Simões M, Soares-Jr J, Baracat E.
SourceGynecology Department, Federal University of São Paulo, São Paulo,
Brazil.
Abstract
OBJECTIVE: The aim of this study was to evaluate the effects of isoflavones on
the skin of postmenopausal women.
DESIGN: A prospective study was performed with 30 postmenopausal women
before and immediately after the end of treatment with 100 mg/day of an
isoflavones-rich, concentrated soy extract for six months. A skin punch was
performed in the gluteal region for sample collection before and immediately
after the treatment program. Morphometric determination of epidermal
thickness, the papillary index (wrinkling), and the amount of dermal elastic and
collagen fibers was assessed. In addition, the number of blood vessels in the
sample was also evaluated. The paired Student's t-test was used for statistical
analysis (P < 0.05).
RESULTS: Isoflavone treatment resulted in a 9.46% increase in the thickness of
the epidermis in 23 patients. In addition, the papillary index was reduced in 21
women. The papillary index was inversely proportional to skin wrinkling, i.e.,
there were a large number of papillae after treatment. The amount of collagen in
the dermis was increased in 25 women (86.2%). In 22 women (75.8%) we
observed that the number of elastic fibers increased. The number of dermal
blood vessels was significantly increased in 21 women.
CONCLUSION: Our data show that the use of a concentrated, isoflavone-rich
soy extract during six consecutive months caused significant increases in
epithelial thickness, the number of elastic and collagen fibers, as well as the
blood vessels.
PMID:19578653[PubMed - indexed for MEDLINE]
Biofactors. 2003;18(1-4):289-97.
The combined use of oral and topical lipophilic antioxidants increases
their levels both in sebum and stratum corneum.
Passi S, De Pità O, Grandinetti M, Simotti C, Littarru GP.
SourceCentro Invecchiamento Cellulare, I.D.I. (IRCCS), Rome, Italy.
[email protected]
Abstract
The concentration of Vitamin E (vit E) and ubiquinone (CoQ10), which together
with squalene (SQ), play a key role against external oxidative insult, has been
shown to decrease significantly during ageing. The aim of the present study is
to inquire the effect of the combined use of topical bio-cosmetics containing
natural active principles (including sebum-like lipid fractions, sebum and
epidermal lipophilic and hydrophilic antioxidants), and oral antioxidant
supplements on the antioxidant content of sebum and stratum corneum. We
therefore treated the face and the back of 50 female volunteers aged 21-40,
daily for two months, with a base cream containing 0.05% ubiquinone, 0.1% vit
E, and 1% squalene. In addition 50 mg of CoQ10 + 50 mg of d-RRR-alphatocopheryl acetate + 50 microg of selenium were administered orally to half of
the volunteers (Group A). Group B was represented by 25 volunteers who were
treated only topically. Every 15 days during treatment the levels of CoQ10, vit E
and SQ were verified in sebum, stratum corneum, and plasma. The daily topical
application of the cream led to a significant increase, that peaked after 60 days,
of the levels of CoQ10, d-RRR-alpha-tocopherol and SQ in the sebum (Group
B), without significantly affecting the stratum corneum or plasma concentrations
of the redox couple CoQ10H2/CoQ10 and vit E. The concomitant oral
admistration of antioxidants produced in Group A a significant increase of the
levels of CoQ10H2/CoQ10 and vit E both in plasma and stratum corneum after
15 and 30 days treatment respectively, compared to Group B. However the
sebum levels of lipophilic antioxidants and SQ did not show a significant
increase. After the treatments, the levels of CoQ10H2/CoQ10, vit E and SQ
went back to basal levels within 6-8 days in sebum, 12-16 days in the stratum
corneum, and 3-6 days in plasma. Therefore topical application of the
antioxidants was able to increase their level in sebum, while the concomitant
oral administration also affected the levels of vit E and CoQ10 in the stratum
corneum.
PMID:14695946[PubMed - indexed for MEDLINE]
Nutr Neurosci. 2010 Jun;13(3):116-22.
Improved cognitive-cerebral function in older adults with chromium
supplementation.
Krikorian R, Eliassen JC, Boespflug EL, Nash TA, Shidler MD.
SourceDepartment of Psychiatry, University of Cincinnati College of Medicine,
PO Box 670559, Cincinnati, Ohio 45267-0559, USA. [email protected]
Abstract
Insulin resistance is implicated in the pathophysiological changes associated
with Alzheimer's disease, and pharmaceutical treatments that overcome insulin
resistance improve memory function in subjects with mild cognitive impairment
(MCI) and early Alzheimer's disease. Chromium (Cr) supplementation improves
glucose disposal in patients with insulin resistance and diabetes. We sought to
assess whether supplementation with Cr might improve memory and neural
function in older adults with cognitive decline. In a placebo-controlled, doubleblind trial, we randomly assigned 26 older adults to receive either chromium
picolinate (CrPic) or placebo for 12 weeks. Memory and depression were
assessed prior to treatment initiation and during the final week of treatment. We
also performed functional magnetic resonance imaging (fMRI) scans on a
subset of subjects. Although learning rate and retention were not enhanced by
CrPic supplementation, we observed reduced semantic interference on
learning, recall, and recognition memory tasks. In addition, fMRI indicated
comparatively increased activation for the CrPic subjects in right thalamic, right
temporal, right posterior parietal, and bifrontal regions. These findings suggest
that supplementation with CrPic can enhance cognitive inhibitory control and
cerebral function in older adults at risk for neurodegeneration.
PMID:20423560[PubMed - indexed for MEDLINE]
Nutr Res. 2008 May;28(5):315-20.
Reduction of cardiovascular risk factors in subjects with type 2 diabetes
by Pycnogenol supplementation.
Zibadi S, Rohdewald PJ, Park D, Watson RR.
SourceNutritional Sciences Department, The University of Arizona, Tucson, AZ
85721, USA.
Abstract
Patients with type 2 diabetes are at considerable risk of excessive morbidity and
mortality from cardiovascular disease (CVD). We investigated the clinical
effectiveness of Pycnogenol, a flavonoid-rich dietary supplement, in reducing
antihypertensive medication use and CVD risk factors in subjects with type 2
diabetes. Forty-eight individuals were enrolled in a randomized, double-blind,
placebo-controlled trial with parallel-group design. Patients were diagnosed with
both type 2 diabetes and mild to moderate hypertension and were undergoing
treatment with angiotensin-converting enzyme (ACE) inhibitors. Subjects were
randomly assigned to receive either Pycnogenol pill (125 mg daily) or matched
placebo for 12 weeks. According to the values of blood pressure (BP) measured
at 2-week intervals, the pretrial ACE inhibitor dosage was left unchanged,
reduced by 50%, or brought back to the pretrial dosage until a stable BP was
obtained. Fasting plasma glucose, low-density lipoprotein (LDL) cholesterol,
glycosylated hemoglobin (HbA1c), serum endothelin-1, and urinary albumin
were evaluated monthly. Pycnogenol treatment achieved BP control in 58.3% of
subjects at the end of the 12 weeks with 50% reduction in individual pretrial
dose of ACE-inhibitors (P <.05). Plasma endothelin-1 decreased by 3.9 pg/mL
in Pycnogenol-treated group vs 0.5 pg/mL increase in control group (P < .001).
Mean HbA1c dropped by 0.8% in Pycnogenol-treated group (P < .05), whereas
it decreased by 0.1% in control group. Fasting plasma glucose declined by 23.7
mg/dL in Pycnogenol-treated group vs 5.7 mg/dL in control group (P < .0001).
Low-density lipoprotein cholesterol improved significantly in Pycnogenol-treated
group, declining by 12.7 mg/dL (P < .001). A significant decrease in urinary
albumin level was observed at week 8 compared with the control group (P <
.05). However, this reduction was not significant at 12th week. After 12 weeks of
supplementation, Pycnogenol resulted in improved diabetes control, lowered
CVD risk factors, and reduced antihypertensive medicine use vs controls.
PMID:19083426[PubMed - indexed for MEDLINE]