Drogenschnelltest-Gebrauchsanweisung | Dip / Multi-Dip
Transcrição
Drogenschnelltest-Gebrauchsanweisung | Dip / Multi-Dip
Drogenschnelltest-Gebrauchsanweisung | Dip / Multi-Dip Deutsch 1. Anwendungsbereich 5. Cut-offs Einstufige Sandwich-Immunoassays zur qualitativen Bestimmung verschiedener Drogen und Drogenmetaboliten im humanen Urin. Der Test ist nur für den professionellen Gebrauch vorgesehen (medizinische Fachkreise). 2. Testdurchführung 1) Entnehmen Sie den Test der Umverpackung. Bei Multitests Schutzkappe abziehen. Kühl gelagerte Tests bzw. Urinproben vorher auf Raumtemperatur bringen. 2) Tauchen Sie die Streifen ca. 10-15 Sekunden in den Urin; der Plastikrand darf den Urin nicht berühren. 3) Lesen Sie das Ergebnis nach ca. 5 Minuten ab. Nach 10 Minuten keine Ergebnisse mehr auswerten. 3. Testauswertung Im Reaktionsfeld befinden sich die Testzonen (T) der nachzuweisenden Substanzen sowie eine Kontrollzone (C). • Bei einem negativen Ergebnis, also einer drogen-freien Urinprobe, er scheint ein pinkfarbener Streifen in der Testzone (T) und ein Streifen in der Kontrollzone (C) • Bei einem positiven Ergebnis ist nur noch ein Streifen in der Kontrollzone (C) erkennbar. Ist in der Kontrollregion (C) kein Streifen erkennbar, so ist z.B. nicht genügend Urin aufgetragen worden und der Test ist ungültig! Parameter* Droge/Metabolit** AMP BAR BZD BUP COC COT DOL EDDP EtG FYL KET MDA MDMA/XTC MTD MES MET MOR/OPI MPD MQL OXY PCP PPX PCM Spice/K2 TCA THC Amphetamin Secobarbital Oxazepam Buprenorphin-β3-D-Glucuronid Benzoylecgonin Cotinin Pethidine 2-Ethylidin-1,5-Dimethyl-3,3Diphenylpyrrolidin Ethylglucuronid Fentanyl Ketamin Methylendioxyamphetamin 3,4-Methylendioxy-Metamphetamin Methadon Meskalin Methamphetamin Morphin Methylphenidat Methaqualon Oxycodon Phencyclidin Norpropoxyphen Paracetamol/Acetaminophen JWH-073/JWH-018 Nortriptylin 11-nor-Δ9-THC-9-COOH TML TZD ZAL ZOL Tramadol Trazodon Zaleplon Zolpidem verfügbare Cut-offs (ng/ml) 1000 / 500 / 300 300 / 200 300 / 200 / 100 10 / 5 600 / 300 / 200 / 100 1000 / 200 1000 100 500 10 1000 500 500 300 / 250 500 1000 / 500 / 300 2000 / 300 / 100 300 300 100 25 300 5000 50 1000 / 300 500 / 300 / 200 / 150 / 50 / 25 200 / 100 25 100 50 Einzeltest: *auf den Test gedruckte Abkürzung **Verbindung, die als Kalibrator zur Einstellung des jeweiligen Cut-Offs benutzt wurde. Negativ Positiv Ungültig Multitest: AMP BZD COC MOR THC AMP BZD COC MOR THC Negativ für BZD+MOR Ungültig Positiv für AMP+COC+THC Hinweis: Die Farbintensität der Streifen auf der Testmembran kann bei den einzelnen Parametern unterschiedlich sein. Nur wenn kein Streifen erscheint, ist der Test positiv. Positive und unklare Resultate sollten mit einer zweiten analytischen Methode bestätigt werden (z.B. GC/MS). Buprenorphin wird ab einer Tagesdosis von 2 mg zuverlässig erfasst. 4. Warnungen und Vorsichtsmaßnahmen • Nur für die in vitro Diagnose vorgesehen. • Gebrauch nur für den Fachkreis bestimmt. • Nach Ablauf des Verfalldatums den Test nicht mehr verwenden. • Urinproben können infektiös sein. Deshalb werden saubere Handhabung und sichere Aufbewahrung von verwendeten Teststreifen in geeigneten Laborabfallbehältern empfohlen. • Die Tests bei 2-30°C lagern und nicht einfrieren. • Test bei beschädigter Schutzverpackung nicht mehr verwenden. • Nach der Entnahme aus der Schutzverpackung Test sofort verwenden und nicht auf die Saugfläche greifen. 1 • Nur zum Einmalgebrauch. 6. Literatur 1) 2) 3) 4) 5) 6) 7) 8) 9) 10) 11) 12) Aniline O., Pittes, F. N., Phencyclidine (PCP): A review and perspectives. CRC Crit. Rev. Toxicol, 1982, 10, 145-177. Baselt, R.C. Disposition of Toxic Drugs and Chemicals in Man. Biomedical Publications, Davis, CA, 1982. Thomas L. eds., Labor und Diagnose, 6. ed., TH-Books Verlagsgesellschaft, Frankfurt, 2005 Urine Testing for Drugs of Abuse, National Institute on Drug. Abuse (NIDA), Research Monograph 73, 1986. Ellenhorn, M.J. and Barceloux, D.G. Medical Toxicology. Elsevier Science Publishing Company, Inc., New York, 1988. Fed. Register, Department of Health and Human Services, Mandatory Guidelines for Federal Workplace Drug Testing Programs, 53, 69, 11970-11979, 1988. Gilman, A. G., and Goodman, L. S. The Pharmacological Basis of Therapeutics, eds. MacMillan Publishing, New York NY, 1980. Gorodetzkym, C. W., Detection of Drugs of Abuse in Biological Fluids, in Martin WR(ed): Drug Addiction I, New York, Spring-Verlag, 1977. Greenblatt, D.J., Shader, R.I. Benzodiazepines in Clinical Practice. New York: Raven Press, 1974. Harvey, R.A., Champe, P.C. Lippincotts Illustrated Reviews. Pharmacology. 91-95, 1992. Hofmann F.E., A Handbook on Drug and Alcohol Abuse: The Biomedical Aspects, New York, Oxford University Press, 1983. McBay, A. J., Clin. Chem. 33, 33B-40B, 1987 Drogenschnelltest-Gebrauchsanweisung | Dip / Multi-Dip 1. Intended Use English 5. Cut-offs Single-sandwich immunoassays for qualitative determination of various drugs and drug metabolites in human urine. The test should only to be used by medical professionals. 2. Procedure of the Test 1) Remove the test from the packaging. Bring urine samples to room temperature before performing the test. 2) Immerse the strip for approximately 10 to 15 seconds in the urine; be sure that the edge of the plastic does not touch the urine. 3) Wait approximately 5 minutes before reading the results. Do not evaluate results after 10 minutes, as they are no longer valid. 3. Interpretation of the Results The test zone (T) detects drug substances found in the urine sample, the remaining zone (C) is the control zone. • With a negative result, and therefore a drug-free urine sample, a pink stripe will appear in both the test zone (T) and in the control zone (C). • With a positive result a pink stripe will only appear in the control zone (C). If the control region (C) has no distinguishable line, not enough urine has been applied and the test is invalid! If the control region (C) has no distinguishable line, not enough urine has been applied and the test is invalid! Singletest: Parameter* Drug/Metabolite** AMP BAR BZD BUP COC COT DOL EDDP EtG FYL KET MDA MDMA/XTC MTD MES MET MOR/OPI MPD MQL OXY PCP PPX PCM Spice/K2 TCA THC Amphetamine Secobarbital Oxazepam Buprenorphine-β3-D-Glucuronide Benzoylecgonine Cotinine Pethidine 2-Ethylidine-1,5-Dimethyl-3,3Diphenylpyrrolidine Ethyl glucuronide Fentanyl Ketamin Methylendioxyamphetamine 3,4-Methylendioxy-Metamphetamine Methadone Mescaline Methamphetamine Morphine Methylphenidate Methaqualone Oxycodone Phencyclidine Norpropoxyphene Paracetamol/Acetaminophen JWH-073/JWH-018 Nortriptyline 11-nor-Δ9-THC-9-COOH TML ZAL ZOL ZOL Tramadol Zaleplon Zolpidem Zolpidem available Cut-offs (ng/ml) 1000 / 500 / 300 300 / 200 300 / 200 / 100 10 / 5 600 / 300 / 200 / 100 200 1000 100 500 10 1000 500 500 300 / 250 500 1000 / 500 / 300 2000 / 300 / 100 300 300 100 25 300 5000 50 1000 / 300 500 / 300 / 200 / 150 / 50 / 25 200 / 100 100 50 50 *Abbreviation printed on test **Substance used for calibration the different cut-off levels. Negative Positive Invalid 6. Multitest: AMP BZD COC MOR THC AMP BZD COC MOR THC Negative for BZD+MOR Invalid Positive for AMP+COC+THC Note: The intensity of the color stripe on the test field can vary depending on the parameters that are being tested. It is only when no stripe appears that the test is positive. Positive results should be confirmed by an additional testing method (GC / MS). Buprenorphine will start being detected at a daily dose of 2 mg. Literatur 1) 2) 3) 4) 5) 6) 7) 8) 9) 10) 11) 12) Aniline O., Pittes, F. N., Phencyclidine (PCP): A review and perspectives. CRC Crit. Rev. Toxicol., 1982, 10, 145-177. Baselt, R.C. Disposition of Toxic Drugs and Chemicals in Man. Biomedical Publications, Davis, CA, 1982. Thomas L. eds., Labor und Diagnose, 6. ed., TH-Books Verlagsgesellschaft, Frankfurt, 2005 Urine Testing for Drugs of Abuse, National Institute on Drug. Abuse (NIDA), Research Monograph 73, 1986. Ellenhorn, M.J. and Barceloux, D.G. Medical Toxicology. Elsevier Science Publishing Company, Inc., New York, 1988. Fed. Register, Department of Health and Human Services, Mandatory Guidelines for Federal Workplace Drug Testing Programs, 53, 69, 11970-11979, 1988. Gilman, A. G., and Goodman, L. S. The Pharmacological Basis of Therapeutics, eds. MacMillan Publishing, New York NY, 1980. Gorodetzkym, C. W., Detection of Drugs of Abuse in Biological Fluids, in Martin WR(ed): Drug Addiction I, New York, Spring-Verlag, 1977. Greenblatt, D.J., Shader, R.I. Benzodiazepines in Clinical Practice. New York: Raven Press, 1974. Harvey, R.A., Champe, P.C. Lippincotts Illustrated Reviews. Pharmacology. 91-95, 1992. Hofmann F.E., A Handbook on Drug and Alcohol Abuse: The Biomedical Aspects, New York, Oxford University Press, 1983. McBay, A. J., Clin. Chem. 33, 33B-40B, 1987. 4. Warnings and Precautions • For in vitro diagnostic use only. • To be used by medical professionals only. • After the expiry date, the test is no longer valid. • Urine samples can be infectious. Therefore, clean handling and secure storage of test strips is recommended. • Store the tests between 2-30°C and be sure to not freeze the tests. • Tests with damaged packaging should not be used. • After removing the test from the protective packaging, the test should be used immediately. • For one time use only. 2 Drogenschnelltest-Gebrauchsanweisung | Dip / Multi-Dip Français 1. Domaine d’application 5. Cut-offs Ce test utilise la méthode en Sandwich-Immunoassays pour la détection qualitative de drogues et de leurs métabolites dans les urines humaines. Le test est uniquement prévu à un usage professionnel (milieux spécialisés). 2. Exécution du test 1) Retirer le test de son emballage. Les tests ainsi que les urines conservés au frais doivent être amenés à température ambiante. 2) Tremper la bandelette dans l`urine pendant 15-30 secondes; la partie en plastique ne doit pas entrer en contact avec l`urine3) 3) Lire les résultats après 5 minutes. Ne pas interpreter les résultats après 10 minutes 3. Interprétation des résultats Au niveau de la zone de réaction, se trouvent les zones de test (T) et les zones de contrôle. (C). • Pour un résultat négatif, donc réalisé sur un échantillon d’urine ne contenant pas de drogue, une ligne de couleur rose apparaîtra dans la zone de test (T) ainsi que dans la zone de contrôle (C). • Pour un résultat positif, une seule ligne apparaît dans la zone de contrôle (C). Si aucune ligne n’apparaît dans la zone de contrôle (C), cela peut provenir du fait qu’il n’y a pas assez d’urine. Le test est considéré comme non valide. Einzeltest: Paramètres* Drogues/Métabolites** AMP BAR BDZ BUP COC COT DOL EDDP EtG FYL KET MDA MDMA/XTC MTD MES MET MOR/OPI MPD MQL OXY PCP PPX PCM Spice/K2 TCA THC Amphétamine Sécobarbital Oxazépam Buprénorphine Benzoylecgonine Cotinine Péthidine 2-Ethylidin-1,5-Dimethyl-3,3Diphenylpyrrolidin Ethylglucuronide Fentanyl Kétamine Methylendioxyamphétamine 3,4-Methylendioxy-Métamphétamine Méthadone Mescaline Métamphétamine Morphine Méthylphénidate Méthaqualone Oxycodone Phencyclidine Norpropoxyphène Paracétamol/Acétaminophène JWH-073/JWH-018 Nortriptyline 11-nor-Δ9-THC-9-COOH TML TZD ZAL ZOL Tramadol Trazodon Zaleplon Zolpidem Cut-off disponibles (ng/ml) 1000 / 500 / 300 300 / 200 300 / 200 / 100 10 / 5 600 / 300 / 200 / 100 1000 / 200 1000 100 500 10 1000 500 500 300 / 250 500 1000 / 500 / 300 2000 / 300 / 100 300 300 100 25 300 5000 50 1000 / 300 500 / 300 / 200 / 150 / 50 / 25 200 / 100 25 100 50 *Abréviation figurant sur le test **Substance ayant été utilisée comme calibrateur pour le réglage des différents cut-offs. Négatif Positif Non valide 6. Multitest: AMP BZD COC MOR THC Négatif pour BZD+MOR AMP BZD COC MOR THC Non valide Positif pour AMP+COC+THC Indication: L’intensité de la couleur de la bandelette sur la membrane du test peut être différente selon les paramètres unitaires. Le test est positif seulement quand aucune ligne n’apparaît. Les résultats positifs et douteux devront être confirmés par une deuxième méthode d’analyse (par exemple GC/MS). La buprénorphine sera détectée à partir d’une dose journalière de 2mg. 4. Précautions et mesures de sécurité • Réservé uniquement à une utilisation In-vitro • Réservé à un usage professionnel. • Ne pas utiliser au-delà de la date de péremption. • Les échantillons d’urines doivent être considérés comme potentiellement infectieux. Les manipuler et procéder à l’élimination selon les règles en vigueur. • Conserver les tests à une température de 2-30°C et ne pas congeler. • Ne pas utiliser le test si son emballage est endommagé. • Utiliser immédiatement le test après ouverture de son emballage. • Réservé à une utilisation unique. 3 Bibliographie 1) Aniline O., Pittes, F. N., Phencyclidine (PCP): A review and perspectives. 2) 3) 4) 5) 6) 7) 8) 9) 10) 11) 12) CRC Crit. Rev. Toxicol, 1982, 10, 145-177. Baselt, R.C. Disposition of Toxic Drugs and Chemicals in Man. Biomedical Publications, Davis, CA, 1982. Thomas L. eds., Labor und Diagnose, 6. ed., TH-Books Verlagsgesellschaft, Frankfurt, 2005 Urine Testing for Drugs of Abuse, National Institute on Drug. Abuse (NIDA), Research Monograph 73, 1986. Ellenhorn, M.J. and Barceloux, D.G. Medical Toxicology. Elsevier Science Publishing Company, Inc., New York, 1988. Fed. Register, Department of Health and Human Services, Mandatory Guidelines for Federal Workplace Drug Testing Programs, 53, 69, 11970-11979, 1988. Gilman, A. G., and Goodman, L. S. The Pharmacological Basis of Therapeutics, eds. MacMillan Publishing, New York NY, 1980. Gorodetzkym, C. W., Detection of Drugs of Abuse in Biological Fluids, in Martin WR(ed): Drug Addiction I, New York, Spring -Verlag, 1977. Greenblatt, D.J., Shader, R.I. Benzodiazepines in Clinical Practice. New York: Raven Press, 1974. Harvey, R.A., Champe, P.C. Lippincotts Illustrated Reviews. Pharmacology. 91-95, 1992. Hofmann F.E., A Handbook on Drug and Alcohol Abuse: The Biomedical Aspects, New York, Oxford University Press, 1983. McBay, A. J., Clin. Chem. 33, 33B-40B, 1987. Drogenschnelltest-Gebrauchsanweisung | Dip / Multi-Dip 1. Uso Previsto Italiano 5. Cut-offs Il single-sandwich immunoassays è un test qualitativo immunocromatografico per rilevare rapidamente la presenza di diversi tipi di droghe d’abuso e dei loro metaboliti nell’urina umana. Il test è destinato unicamente ad uso professionale. 2. Procedura del Test 1) Rimuovere il test dall’involucro. Portare i campioni a temperatura ambiente prima di effettuare il test. 2) Immergere la striscia nel campione di urina per 10-15 secondi. Fare in modo che l’urina non venga a contatto con la finestra di controllo in plastica. 3) 3 Leggere I risultati dopo 5-10 minuti. Non leggere il risultato dopo 10 minuti. 3. Interpretazione dei Risultati La zona del test (T) rileva sostanze trovate nel campione d’urina e l’altra è la zona di controllo. • Con risultato negativo, appariranno una linea colorata (rosa) nella banda di rilevazione del test (T) e una linea colorata nell’area di controllo (C). • Con un risultato positivo è visibile una linea colorata solo nell’area di controllo (C). Se non appare nessuna banda nella zona di controllo, il test non è valido, forse per un volume di urina insufficiente. Singletest: Parametro* Droga/Metabolita** AMP BAR BZD BUP COC COT DOL EDDP EtG FYL KET MDA MDMA/XTC MTD MES MET MOR/OPI MPD MQL OXY PCP PPX PCM Spice/K2 TCA THC Amfetamina Secobarbitolo Oxazepam Buprenorfina-ß3-D-Glucoronide Benzoilecgonina Cotinina Petidina 2-Etilidina-1,5-Dimetil-3,3Definilpiralina Etilglucoronide Fentanyl Chetamina Metilendiossiamfetamina 3,4-Metilendiossimetanfetamina Metadone Mescalina Metamfetamina Morfina Metilfenidato Metaqualone Ossicodone Fenciclidina Norpropossifene Acetaminofene JWH-073/JWH-018 Nortriptilina 11-nor-Δ9-THC-9-COOH TML TZD ZAL ZOL Tramadolo Trazodon Zaleplon Zolpidem Cut-off disponibili (ng/ml) 1000 / 500 / 300 300 / 200 300 / 200 / 100 10 / 5 600 / 300 / 200 / 100 1000 / 200 1000 100 500 10 1000 500 500 300 / 250 500 1000 / 500 / 300 2000 / 300 / 100 300 300 100 25 300 5000 50 1000 / 300 500 / 300 / 200 / 150 / 50 / 25 200 / 100 25 100 50 *sigla stampata sul test **sostanza utilizzata per la calibrazione dei rispettivi Cut-off. Negativo Positivo Non valido 6. Multitest: AMP BZD COC MOR THC AMP BZD COC MOR THC Negativo per BZD+MOR Non valido Positivo per AMP+COC+THC Note: L’intensità del colore delle linee di test può variare per i diversi parametri. Il test è considerato positivo solo se non compare la linea del test. I risultati positivi e quelli non chiari devono essere ripetuti con un metodo analitico alternativo (GC/MS). La buprenorfina è rilevabile in modo attendibile con un dosaggio giornaliero di 2 mg o superiore. 4. Avvertenze e precauzioni Riferimenti Bibliografici 1) 2) 3) 4) 5) 6) 7) 8) 9) 10) 11) 12) Aniline O., Pittes, F. N., Phencyclidine (PCP): A review and perspectives. CRC Crit. Rev. Toxicol, 1982, 10, 145-177. Baselt, R.C. Disposition of Toxic Drugs and Chemicals in Man. Biomedical Publications, Davis, CA, 1982. Thomas L. eds., Labor und Diagnose, 6. ed., TH-Books Verlagsgesellschaft, Frankfurt, 2005 Urine Testing for Drugs of Abuse, National Institute on Drug. Abuse (NIDA), Research Monograph 73, 1986. Ellenhorn, M.J. and Barceloux, D.G. Medical Toxicology. Elsevier Science Publishing Company, Inc., New York, 1988. Fed. Register, Department of Health and Human Services, Mandatory Guidelines for Federal Workplace Drug Testing Programs, 53, 69, 11970-11979, 1988. Gilman, A. G., and Goodman, L. S. The Pharmacological Basis of Therapeutics, eds. MacMillan Publishing, New York NY, 1980. Gorodetzkym, C. W., Detection of Drugs of Abuse in Biological Fluids, in Martin WR(ed): Drug Addiction I, New York, Spring -Verlag, 1977. Greenblatt, D.J., Shader, R.I. Benzodiazepines in Clinical Practice. New York: Raven Press, 1974. Harvey, R.A., Champe, P.C. Lippincotts Illustrated Reviews. Pharmacology. 91-95, 1992. Hofmann F.E., A Handbook on Drug and Alcohol Abuse: The Biomedical Aspects, New York, Oxford University Press, 1983. McBay, A. J., Clin. Chem. 33, 33B-40B, 1987 • Solo per uso in vitro. • Solo per uso professionale. • Non utilizzare dopo la data di scadenza. • I campioni possono essere potenzialmente infetti. Manipolarli con le dovute precauzioni e smaltirli in modo adeguato. • Conservare e trasportare sempre a temperature comprese tra 2-30°C e assicurarsi di non congelare i test. • Non utilizzare il test se l’involucro è danneggiato. • Utilizzare il test subito dopo aver aperto l’involucro. • Monouso. 4 Drogenschnelltest-Gebrauchsanweisung | Dip / Multi-Dip Detailed list of cut-offs Alcohol The urine alcohol test strip reacts with methyl, ethyl and allyl alcohol. The following substances may interfere with test strips. Yet these substances do not normally occur in sufficient quantities in human urine, in order to influence the test: Ascorbic acid L-methyl-dopa Oxalic acid Pyrogallol Uric acid Bilirubin Methampyrone Mercaptans Peroxidase Strong oxidizing agents tosylates Tannic acid L-Dopa Amphetamine Drug - Cut-off 1000 ng/ml D-Amphetamine L-Amphetamine D-Methamphetamine L-Methamphetamine 3,4-Methylenedioxyamphetamine (MDA) 3,4-Methylenedioxymethamphetamine (MDMA) 3,4-Methylenedioxy-N-ethylamphetamine (MDEA) para-Methoxyamphetamine (PMA) Concentration (ng/ml) 1.000 100.000 >20.000 >20.000 1.250 >20.000 >100.000 625 Drug - Cut-off 500 ng/ml D-Amphetamine L-Amphetamine 3,4-Methylenedioxyamphetamine (MDA) 3,4-Methylenedioxy-N-ethylamphetamine (MDEA) Concentration (ng/ml) 500 15.000 700 12.000 Drug – Cut-off 300 ng/ml D-Amphetamine L-Amphetamine 3,4-Methylenedioxyamphetamine (MDA) 3,4-Methylenedioxy-N-ethylamphetamine (MDEA) Concentration (ng/ml) 300 >50.000 500 >20.000 Barbiturate Drug – Cut-off 300 ng/ml Secobarbital Phenobarbital Butalbital Allobarbital Alphenal Amobarbital Aprobarbital Hexobarbital Butabarbital Concentration (ng/ml) 300 300 3.000 5.000 625 600 600 >100.000 75 Drug – Cut-off 200 ng/ml Secobarbital Concentration (ng/ml) 200 Benzodiazepine Drug – Cut-off 300 ng/ml Oxazepam OH-Alprazolam Prazepam-d5 Nordiazepam 2OH-Ethylflurazepam Diazepam Trizolam Lorazepam Phenazepam 7-NH2-Clonazepam Temazepam 7-NH2-Flunizepam Bromazepam Oxazepam-Gluc a-OH-Midazolam Nitrazepam 5 Concentration (ng/ml) 300 600 >30000 300 3000 240 480 600 750 >30000 90 >30000 420 330 >30000 >30000 Drug – Cut-off 200 ng/ml Oxazepam OH-Alprazelam Prazepam-d5 Nor-Diazepam 2OH-Ethylflurazepam Diazepam Trizolam Lorazepam Phenazepam 7-NH2-Clonazepam Temazepam 7-NH2-Flunizepam Bromazepam Oxazepam-Gluc a-OH-Midazolam Nitrazepam Concentration (ng/ml) 200 400 >20000 200 2000 160 320 600 500 >20000 60 >20000 280 220 >20000 >20000 Drug – Cut-off 100 ng/ml Oxazepam OH-Alprazelam Prazepam-d5 Nor-Diazepam 2OH-Ethylflurazepam Diazepam Trizolam Lorazepam Phenazepam 7-NH2-Clonazepam Temazepam 7-NH2-Flunizepam Bromazepam Oxazepam-Gluc a-OH-Midazolam Nitrazepam Concentration (ng/ml) 100 200 >10000 100 1000 80 160 200 250 >10000 30 >10000 140 110 >10000 >10000 Buprenorphine Drug – Cut-off 10 ng/ml Buprenorphine Buprenorphine-3-β-d-glucunoride Norbuprenorphine Norbuprenorphine-3-β-d-glucunoride Concentration (ng/ml) 10 10 12,5 500 Drug – Cut-off 5 ng/ml Buprenorphine Buprenorphine-3-β-d-glucunoride Norbuprenorphine Norbuprenorphine-3-β-d-glucunoride Concentration (ng/ml) 5 5 6,25 250 Cocaine Drug – Cut-off 300 ng/ml Benzoylecgonin Kokain Ecgonin Ecgonin-Methylester Concentration (ng/ml) 300 1.000 >40.000 >100.000 Drug – Cut-off 200 ng/ml Benzoylecgonine Cocaine Ecgonine Ecgonin-Methylester Concentration (ng/ml) 200 800 >40.000 >100.000 Drug – Cut-off 100 ng/ml Benzoylecgonine Cocaine Ecgonine Ecgonin-Methylester Concentration (ng/ml) 100 300 >40.000 >100.000 Drogenschnelltest-Gebrauchsanweisung | Dip / Multi-Dip Detailed list of cut-offs Cotinine Drug – Cut-off 200 ng/ml Cotinin (-)-Nikotin Concentration (ng/ml) 200 >50.000 EDDP Drug – Cut-off 100 ng/ml 2-Ethylidene-1,5-dimethyl-3,3diphenylpyrrolidine (EDDP) Doxylamine Methadone Methadol Concentration (ng/ml) 100 >1.000.000 >10.000 >10.000 Fentanyl Drug – Cut-off 10 ng/ml Fentanyl und Metabolite Concentration (ng/ml) 10 Ketamine Drug – Cut-off 1000 ng/ml Ketamine Norketamine Phencyclidine Dextromethorphan Lidocaine Promethazine D-Amphetamine Methadone Methadol Pethidine Methampetamine 3,4-Methylenedioxymethamphetamine (MDMA) Concentration (ng/ml) 1.000 2.000 >10.000 1.000 >100.000 20.000 >100.000 25.000 50.000 12.500 12.500 >100.000 MDA-Methylendioxyamphetamin Drug – Cut-off 500 ng/ml 3,4-Methylenedioxyamphetamine (MDA) 3,4-Methylenedioxy-N-ethylamphetamine (MDEA) Concentration (ng/ml) 500 300 MDMA-Methylendioxymethamphetamin Drug - Cut-off 500 ng/ml 3,4-Methylenedioxymethamphetamine (MDMA) 3,4-Methylenedioxyamphetamine (MDA) 3,4-Methylenedioxy-N-ethylamphetamine (MDEA) D-Amphetamine D-Methamphetamine para-Methoxyamphetamine (PMA) Concentration (ng/ml) 500 1.000 300 >100.000 >100.000 5.000 Methadone Drug – Cut-off 300 ng/ml Methadone Methadol Dimenhydrinate 2-Ethylidene-1,5-dimethyl-3,3diphenylpyrrolidine (EDDP) Doxylamine Concentration (ng/ml) 300 1.000 2.500 >40.000 >40.000 Drug – Cut-off 500 ng/ml D-Methamphetamine D-Amphetamine Chloroquine (±)-Ephedrine L-Methamphetamine Mephentermin 3,4-Methylenedioxymethamphetamine (MDMA) Procaine β-Phenylethylamine Ranitidine Concentration (ng/ml) 500 >50.000 >50.000 >50.000 >50.000 >50.000 700 20.000 30.000 >50.000 Drug – Cut-off 300 ng/ml D-Methamphetamine D-Amphetamine Chloroquine (±)-Ephedrine L-Methamphetamine Mephentermine 3,4-Methylenedioxymethamphetamine (MDMA) 3,4-Methylenedioxy-N-ethylamphetamine (MDEA) Procaine β-Phenylethylamine Ranitidine Concentration (ng/ml) 300 >40.000 5.000 >100.000 10.000 50.000 1.000 10.000 35.000 35.000 35.000 Methylphenidate Drug – Cut-off 300 ng/ml Methylphenindate Ritalinic Acid Konzentration (ng/ml) 300 25 000 Methaqualone Drug – Cut-off 300 ng/ml Methaqualone Mecloqualone 3’-Hydroxymethaqualone 4’-Hydroxymethaqualone 2’-Hydroxymethaqualone Amitriptyline Carbamazepine Nortriptyline Phenytoine Primidone Theophylline Konzentration (ng/ml) 300 500 500 500 3.000 50.000 20.000 50.000 40.000 24.000 40.000 Morphine/Opiates Drug – Cut-off 2000 ng/ml Morphine Codeine Diacetylmorphine (Heroin) Ethylmorphi ne Hydromorphone Hydrocodone Merperidine 6-Monoacetylmorphine Morphine-3-β-d-glucuronide Oxycodone Oxymorphone Rifampicin Thebaine Concentration (ng/ml) 2.000 2.000 2.000 600 15.000 15.000 >100.000 5.000 10.000 >20.000 >20.000 >50.000 20.000 Methamphetamine Drug – Cut-off 1000 ng/ml D-Methamphetamine D-Amphetamine Chloroquine (+/-)-Ephedrine L-Methamphetamine 3,4-Methylenedioxyamphetamine (MDA) 3,4-Methylenedioxymethamphetamine (MDMA) 3,4-Methylenedioxy-N-ethylamphetamine (MDEA) Procaine Concentration (ng/ml) 1.000 >40.000 10.000 >100.000 15.000 >10.000 2.000 20.000 100.000 6 Drogenschnelltest-Gebrauchsanweisung | Dip / Multi-Dip Detailed list of cut-offs Pethidine Drug – Cut-off 1000 ng/ml Pethidine Drug – Cut-off 300 ng/ml Morphine Codeine Diacetylmorphine (Heroin) Ethylmorphine Hydromorphone Hydrocodone Merperidine 6-Monoacetylmorphine Morphine-3-β-d-glucuronide Oxycodone Oxymorphone Promethazine Rifampicin Thebaine Trimipramine Concentration (ng/ml) 300 300 300 300 1.500 1.500 >100.000 300 6.000 >20.000 >20.000 >250.000 25.000 2.500 >20.000 Drug – Cut-off 200 ng/ml Morphine Codeine Diacetylmorphine Ethylmorphine Hydromorphone Hydrocodone Meperidine 6-Monoacetylmorphine Morphine-3-β-d-glucuronide Oxycodone Oxymorphone Promethazine Rifampicin Thebaine Trimipramine Concentration (ng/ml) 200 200 200 200 1.000 1.000 >100.000 200 4.000 >20.000 >20.000 >250.000 16.600 1.700 >20.000 Drug – Cut-off 100 ng/ml Morphine Codeine Diacetylmorphine Ethylmorphine Hydromorphone Hydrocodone Meperidine 6-Monoacetylmorphine Morphine-3-β-d-glucuronide Oxycodone Oxymorphone Promethazine Rifampicin Thebaine Trimipramine Concentration (ng/ml) 100 100 100 100 500 500 >100.000 100 2.000 >20.000 >20.000 >250.000 8.400 8.400 >20.000 Oxycodone 7 Phencyclidine Drug – Cut-off 25 ng/ml Phencyclidine Tenocyclidine (TCP) Concentration (ng/ml) 25 3.000 Paracetamol Drug – Cut-off 5000 ng/ml Paracetamol Concentration (ng/ml) 5000 Propoxyphene Drug – Cut-off 300 ng/ml D-Propoxyphene D-Norpropoxyphene Concentration (ng/ml) 300 300 Spice/K2 Morphine Drug – Cut-off 100 ng/ml Oxycodone Oxymorphone Codeine Diacetylmorphine (Heroine) Ethylmorphine Hydrocodone Hydromorphone Merperidine 6-Monoacetylmorphine Morphine Morphine-3-beta-D-glucuronide Thebaine Concentration (ng/ml) 1000 Concentration (ng/ml) 100 500 6.000 >100.000 10.000 10.000 10.000 >100.000 >100.000 >250.000 >100.000 >100.000 Drug – Cut-off 50 ng/ml JWH 073 JWH 018 N-pentanoic acid JWH 018 4-hydroxypentyl JWH 018 N-(5-hydroxypentyl) JWH 018 N-(5-hydroxypentyl)-ß-D-glucuro-nide JWH 073 N-butyl acid JWH 073 3-hydroxybutyl metabolite JWH 122 N-pentanoic acid JWH 122 N-(4-hydroxypentyl) metabolite JWH 210 N-(5-carboxypentyl) metabolite JWH 210 N-(4-hydroxypentyl) metabolite JWH 250 N-(5-carboxypentyl) metabolite JWH 019 N-(6-hydroxyhexyl) metabolite JWH 081 N-(5-hydroxypentyl) metabolite RCS-4 N-(4-hydroxypentyl) metabolite JWH 398 N-(4-hydroxypentyl) metabolite JWH 398 N-pentanoic acid Concentration (ng/ml) 134 29 50 50 25 17 38 63 125 143 143 143 50 125 38 125 112 The following substances have a cross-reaction below 1% with the Spice/K2 Test: Substance JWH018 JWH 122 N-(5-hydroxypentyl) metabolite JWH 250 N-(5-hydroxypentyl) metabolite XLR 11 N-(4-hydroxypentyl) metabolite Substance UR-144 N-(5-hydroxypentyl) metabolite RCS-4 N-(5-carboxypentyl) metabolite JWH 398 N-(5-hydroxypentyl) metabolite UR-144 N-pentanoic acid Tricyclic Antidepressants Drug – Cut-off 1000 ng/ml Nortriptyline Amitriptyline Chlorpromazine Clomipramine Cyclobenzaprine Desipramine Diphenyldramine Doxepin Imipramin Nordoxepin Opipramol Protriptylin Perphenazin Promazine Promethazine Protryptyline Trimipramine Concentration (ng/ml) 1.000 1.000 3.500 10.000 1.500 500 20.000 1.000 800 1.000 4.000 3.000 25.000 200 40.000 3.000 2.500 Drogenschnelltest-Gebrauchsanweisung | Dip / Multi-Dip Detailed list of cut-offs Drug – Cut-off 300 ng/ml Nortriptyline Amitriptyline Chlorpromazine Clomipramine Cyclobenzaprine Desipramine Diphenyldramine Doxepin Imipramine Nordoxepine Opipramol Protriptyline Perphenazine Promazine Promethazine Protryptyline Trimipramine Tramadol Concentration (ng/ml) 300 300 1.100 3.300 500 125 7.000 300 200 300 1.250 1.000 7.000 70 12.500 1.000 800 THC (Marihuana) Drug – Cut-off 500 ng/ml 11-nor-Δ8-THC-9-COOH 11-nor-Δ9-THC-9-COOH Concentration (ng/ml) 500 500 Drug – Cut-off 300 ng/ml 11-nor-Δ8-THC-9-COOH 11-nor-Δ9-THC-9-COOH Concentration (ng/ml) 300 300 Drug – Cut-off 200 ng/ml 11-nor-Δ8-THC-9-COOH 11-nor-Δ9-THC-9-COOH 11-Hydroxy-Δ9-Tetrahydrocannabinol ∆8-Tetrahydrocannabinol ∆9-Tetrahydrocannabinol Cannabinol Cannabidiol Concentration (ng/ml) 200 200 >100.000 >80.000 >80.000 >20.000 >100.000 Drug – Cut-off 150 ng/ml 11-nor-Δ8-THC-9-COOH 11-nor-Δ9-THC-9-COOH 11-hydroxy-Δ9-Tetrahydrocannabinol ∆8-Tetrahydrocannabinol ∆9-Tetrahydrocannabinol Cannabinol Cannabidiol Concentration (ng/ml) 150 150 >100.000 80.000 80.000 >20.000 >100.000 Drug – Cut-off 50 ng/ml 11-nor-Δ8-THC-9-COOH 11-nor-Δ9-THC-9-COOH 11-hydroxy-Δ9-Tetrahydrocannabinol Δ8-Tetrahydrocannabinol ∆9-Tetrahydrocannabinol Cannabinol Cannabidiol Concentration (ng/ml) 50 50 >100.000 15.000 15.000 20.000 >100.000 Drug – Cut-off 25 ng/ml 11-nor-Δ8-THC-9-COOH 11-nor-Δ9-THC-9-COOH 11-hydroxy-Δ9-Tetrahydrocannabinol Δ8-Tetrahydrocannabinol ∆9-Tetrahydrocannabinol Cannabinol Cannabidiol Concentration (ng/ml) 25 25 >100.000 10.000 10.000 15.000 >100.000 Drug – Cut-off 200 ng/ml Tramadol Concentration (ng/ml) 200 Drug – Cut-off 100 ng/ml Tramadol N-desmethyl-tramadol O-desmethyl-tramadol Concentration (ng/ml) 100 250 10.000 Trazodone Drug – Cut-off 200 ng/ml Trazodone Trimipramine Concentration (ng/ml) 25 25000 Zaleplon Drug – Cut-off 100 ng/ml Zaleplon Concentration (ng/ml) 100 Zolpidem Drug – Cut-off 50 ng/ml Zolpidem Concentration (ng/ml) 50 With exception of the respective parameters positive reacting drugs and drug metabolites, which are listed above, all below listed compounds react negatively up to a concentration of 100 µg/ml. Acetaminophen Acetone Albumine Ampicillin Aspartam Aspirin Atropine Benzocaine ß-Phenylethylamine Chinidine Chloroquine Chlorpheniramine 4-Dimethylaminoantipyrine Dopamine (3-hydroxytyramine) (-)-Ephedrine (±)-Ephedrine Ethanol Furosemid Guaiacol Glyceryl Ether Hemoglobin Ibuprofen (±)-Isoproterenol Coffein Creatine Lidocaine L-Phenylephrin N-Methyl-Ephedrin (+)-Naproxen ((S)-6-methoxy-methyl-2-naphthaleneacetic acid) Oxalic acid Penicillin-G (Benzylpenicillin) Pheniramine Phenothiazine Procaine Ranitidine Sulindac Tyramine Vitamin C (Ascorbic acid) 8 Drogenschnelltest-Gebrauchsanweisung | Dip / Multi-Dip Contact Stephany Diagnostika Postfach 524 Bruggfeldweg 1 CH-4147 Aesch Fon +41 (0)61 601 44 24 Fax +41 (0)61 601 44 25 [email protected] www.stephany-diagnostika.ch Rev. 1 /05.03.2015 / BS Symbol Deutsch English Français Italiano CE Konformitätszeichen CE marking of conformity Conformité aux normes européennes Conformità europea Gebrauchsanweisung beachten Consult instructions for use Consulter la notice d’utilisation Consultare le istruzioni per l’uso In-vitro-Diagnostika In-vitro diagnostic Dispositif médical de diagnostic in vitro Dispoitivo medico-diagnostico in vitro Temperaturbegrenzung Temperature limitation Limites de température Limiti di temperatura Chargenbezeichnung Batch code Code du lot Codice lotto Nicht zur Wiederverwendung Do not reuse Ne pas réutiliser Non riutilizzare Verwendbar bis Use by Utiliser jusqu’au Utilizzare entro Bestellnummer Catalogue Number Référence du catalogue Riferimento di Catalogo Hersteller Manufacturer Fabricant Fabbricante Ausreichend für <n> Ansätze Sufficient for <n> tests Suffisant pour pour ”n” tests Sufficiente per ”n” saggi