clarinetes Peter Eaton
Transcrição
clarinetes Peter Eaton
CURRICULUM VITAE Name: Eulália Fernanda Alves de Carvalho Pereira Date and place of Birth: Porto, Portugal, 7th September, 1964 Nationality: Portuguese Home Address: Rua Fernão de Magalhães, 70, rc-esq, 4400-145 V. N. Gaia, Portugal Office Address: Departamento de Química e Bioquímica, Faculdade de Ciências do Porto, Rua do Campo Alegre, 687, 4169-007 Porto, Portugal e-mail: [email protected] EDUCATION Ph.D., Chemistry, Faculdade de Ciências da Universidade do Porto, October 1996. B.Sc., Chemistry, Faculdade de Ciências da Universidade do Porto, September, 1986 (Classification: 16/20) ACADEMIC/TEACHING EXPERIENCE Assistant Professor, Departamento de Química, Faculdade de Ciências do Porto, 1996-to date Teaching Assistant, Departamento de Química, Faculdade de Ciências do Porto, 1986-1996 Demonstrator, Departamento de Química, Faculdade de Ciências do Porto, 1986 COURSES TAUGHT: Undergraduate: Graduate: General Chemistry Biological Inorganic Chemistry Inorganic Chemistry Applied Inorganic Chemistry Bioinorganic Chemistry Nanochemistry Bioinorganic Chemistry Laboratory Physical Inorganic Chemistry Materials in Chemistry and Biochemistry RESEARCH ACTIVITY: 1) Nanochemistry a) Optimization of photochemical reduction of metal complexes in several media (micelles, vesicles, liquid-crystals, etc). b) Development of new methodologies for the synthesis of non-spherical nanoparticles c) Development of new methodologies for the synthesis of core-shell nanoparticles (silica, metals, metal oxides) d) Characterization of the nanostructures by Transmission Electron Microscopy (TEM) e) Study of the interaction of nanoparticles with biomolecules f) Nanotoxicology 2) Metallosurfactants a) Synthesis of ligands and metal complexes with amphiphilic properties. b) Chemical characterization: E.A, FAB-MS, 1H and 13 C NMR, FTIR, UV-vis, electrochemistry. c) Morphological characterization: Electron microscopy (TEM, SEM and cryoSEM), Dynamic light-scattering d) Langmuir-Blodgett films e) Applications in catalysis RECENT PARTICIPATIONS IN RESEARCH PROJECTS: Principal investigator: “Metal and magnetic nanoparticles functionalized with biological molecules as bionanoprobes” PTDC/QUI/64484/2006 (finished) “Nanostructures of noble metals in organized media: technological applications” POCTI/QUI/45145/2002 (finished) “Photocatalytic Growth of Metal Nanostructures” Foundation for the Development) FLAD (Luso American Researcher: “Desenvolvimento de um novo método imunológico para o rastreio da leishmaniose canina utilizando nanoparticulas de ouro coloidal” PTDC/CVT/110732/2009 “Multifunctional Nanoparticles for Clinical Diagnosis” PTDC/CTM- NAN/109877/2009 “Sensitive and selective detection of DNA/RNA based on functionalised gold nanoparticles - application to pathogen detection; mutation detection and RNA quantification” PTDC/BIO/66514/2006 (finished) “Nanodiagnostics: gold-nanoprobes for molecular recognition - application to DNA adducts detection; pathogen detection; gene expression and RNA quantification” PTDC/SAU-BEB/66511/2006 (finished). “Design of new metallosurfactants with catalytic relevance: physico-chemical, morphological and reactivity study” POCTI/QUI/38605/2001(finished). “Synthesis, structure, properties, speciation in solution and biological studies of vanadium compounds for the treatment of diabetes.”POCTI/QUI/35368/1999 (finished). “Study of biogenic polyamines and their metal complexes.” POCTI/QUI/33199/1999 (finished). SUPERVISION OF GRADUATE STUDENTS Ph.D students: Paula Maria Leandro Garcia, 2002. Dissertation: “Amphiphilic complexes of iron(II) – morphological and physico-chemical characterization”. Departamento de Química, Faculdade de Ciências da Universidade do Porto. Maria Adelaide de Carvalho Miranda, 7/03/2011. Dissertation: “Metal nanostructures – synthesis and applications”. Departamento de Química, Faculdade de Ciências da Universidade do Porto. Pedro Correia Quaresma, 2007-2012: “NPs with a magnetic core and Au shell for detection and separation of biomolecules”. Departamento de Química, Faculdade de Ciências da Universidade do Porto. Cristina Sofia Neves, 2010-, Dissertation: " Synthesis of novel metal-quantum dot nanoparticles and their use in genetic biosensors", Programa Doutoral em Química Sustentável, REQUIMTE, UP/FCT-UNL Leonor Ricardo Soares, 2011-, Dissertation: "Nanopartículas de ouro anisométricas como sondas para identificação de polimorfismos de DNA associados a doenças metabólicas" Programa Doutoral em Química Sustentável, REQUIMTE, UP/FCT-UNL Master Students: Ana Cristina da Silva Maia, 2000. Dissertation: “Synthesis of iron(II) complexes with ligands derived from 2,2’-bipyridine and cyanide – Polarity probes for pure solvents” Departamento de Química, Faculdade de Ciências da Universidade do Porto. Inês Maria Osório, 2008. Dissertation: “Photocatalytic synthesis of asymmetric gold and silver nanoparticles”, Departamento de Química, Faculdade de Ciências da Universidade do Porto. Leonor Soares, 2009. Dissertation: “Synthesis and functionalization of metal nanoparticles with peptides”, Departamento de Química, Faculdade de Ciências da Universidade do Porto. Eliana Malheiro, 2010. Dissertation: “Kinetic effects in the morphological control of gold nanoparticles”, Departamento de Química, Faculdade de Ciências da Universidade do Porto. Armando Silva, 2010. Dissertation: “Development of methodologies for the synthesis of metal nanoparticles by green chemistry methods”, Departamento de Química, Faculdade de Ciências da Universidade do Porto. Vânia M. P. Vieira, 2011. Dissertation: "Preparação e Funcionalização de Nanopartículas Para Bioensaios." Faculdade de Ciências da Universidade do Porto. Catarina A. D. Loureiro, 2011. Dissertation: "Preparação de Nanopartículas Metálicas Funcionalizadas com Péptidos para Aplicações em Biossensores", Faculdade de Ciências da Universidade do Porto. SUPERVISION OF POST-DOCTORATE PROJECTS Dr. Pedro Quaresma, 2013-. Project: Bionanoconjugates of magnetic/gold nanoparticles and laccase for application in the detection and degradation of environmental pollutants. REQUIMTE-Departamento de Química, Faculdade de Ciências da Universidade do Porto. Dr. Inês Gomes, 2011-. Project: "Malaria Bionanodiagnosis: Gold nanoparticlebased rapid detection test for malaria parasites in clinical samples". Instituto de Medicina Molecular/REQUIMTE (Porto) Dr. Peter Jonathan Eaton, 2004-2006. Project: “AFM characterization of nanostrutures and nanostructured materials”. REQUIMTE-Departamento de Química, Faculdade de Ciências da Universidade do Porto. Dr. Sunita Arun Salunke, 2004-2007. Project: “Metallosurfactants – synthesis, characterization and aggregation properties”. REQUIMTE-Departamento de Química, Faculdade de Ciências da Universidade do Porto. Dr. Elzbieta Skiba, 2005-2006. Project: “Metal nanostructures for catalytic and biological applications”. REQUIMTE-Departamento de Química, Faculdade de Ciências da Universidade do Porto. PUBLICATIONS 1 Copper(II) complexes with 1-(2-carbamylethyl)-2-alkylimidazoles and oxyanions. M. C. R. M. P. Basto, M. J. P. Ferreira, E.F. A. C. Pereira e A. Machado Polyhedron., 1990, 9, 2035. 2 Chemical generation and decomposition of Schiff bases nickel(III) complexes with a N2O2 chromophore. Baltazar de Castro, Cristina Freire, Eulália Pereira J. Inorg. Biochem., 1991, 43, 653. 3 Decomposition of chemically and electrochemically generated Ni(III) complexes with N2O2 Schiff-base ligands.. Baltazar de Castro, Cristina Freire e Eulália Pereira J. Chem. Soc., Dalton Trans., 1994, 571. 4 Nickel complex with an asymmetric N2OS Schiff base ligand. Baltazar de Castro, Eulália Pereira e Lígia Gomes Acta Cryst., 1997, C53, 1572. 5 Synthesis, spectroscopic and electrochemical study of nickel(II) complexes with tetradentate asymmetric Schiff bases derived from salycilaldehyde and methyl 2-aminocyclopentene-dithiocarboxylate. Eulália Pereira, Lígia Gomes e Baltazar de Castro Inorg. Chim. Acta 1998, 271, 83. 6 Synthesis, spectroscopic and electrochemical study of nickel(II) and nickel(I) complexes with Schiff base ligands with a NN’OS coordination sphere. Eulália Pereira, Lígia Gomes e Baltazar de Castro J. Chem. Soc. Dalton Trans. 1998, 629. 7 Nickel complex with a tetradentate N2S2 Schiff-base ligand. Lígia Gomes, Eulália Pereira e Baltazar de Castro Acta Cryst., 1999, C55, 1061-1062 8 Study of copper(II) polyazamacrocylclic complexes by electronic absorption spectrophotometry and EPR spectroscopy. Carlos F. G. C. Geraldes, M. Paula M. Marques, Baltazar de Castro, Eulália Pereira Eur. J. Inorg. Chem., 2000, 559-565 9 Bis-(4-methyl-4’-pentyl-2,2’-bipyridyl)(dicyano)-iron(II): a versatile solvatochromic solvation probe. Paula Gameiro, Ana Maia, Eulália Pereira, Baltazar de Castro e John Burgess Trans. Met. Chem., 2000, 25, 283-286. 10 Nickel (II) complexes with N2OS and N2S2 co-ordination spheres: Reduction and spectroscopic study of the correspondent Ni (I) complexes. Lígia Gomes, Eulália Pereira, Baltazar de Castro J. Chem. Soc., Dalton Trans., 2000, 1373-1379. 11 Structural study of the interaction of vanadate with the ligand 1,2-dimethyl3-hydroxy-4-pyridinone (HDMPP) in aqueous solution. M.M.C.A.Castro, C.F.G.C.Geraldes, P. Gameiro, E. Pereira, B. Castro, M. Rangel. J. Inorg. Biochem., 2000, 80, 177-179 12 Derivatives of bis-2,2'-bipyridyl)dicyano)iron(II) with long alkyl chains Versatile solvatochromic probes that form metalloaggregates in water-rich media . Paula Gameiro, Eulália Pereira, Paula Garcia, Sónia Breia, John Burgess e Baltazar de Castro Eur. J. Inorg. Chem., 2001, 2755-2761. 13 A novel self-indicative vesicle based on a iron(II) complex. Paula Garcia, João Marques, Eulália Pereira, Paula Gameiro, Roberto Salema e Baltazar de Castro Chem.Comm., 2001, 1298-1299. 14 Characterization of the photolysis products of sec-butylcobaloximes with imidazole and benzimidazole bases. Maria Rangel, Eulália Pereira, Celeste Oliveira, Baltazar de Castro J. Organomet. Chem., 2001, 632, 85-93. 15 Cytotoxic effects of metal complexes of biogenic polyamines. I. Platinum(II) spermidine compounds: prediction of their antitumour activity. M. P. ;. Marques, T. Girão, Maria C. Pedroso de Lima, A. Gameiro, E. Pereira, P. Garcia Biochim. Biophys. Acta, 2002, 1589, 63-70. 16 Controlled Synthesis of 2-D and 3-D Dendritic Platinum Nanostructures. Y. Song, Y. Yang, C. J. Medforth, E. Pereira, A. K. Singh, H. Xu, Y. Jiang, C. J. Brinker, F. van Swol, J. A. Shelnutt J. Am. Chem. Soc. 2004, 126, 635-645. 17 Two azurins with unusual redox and spectroscopic properties isolated from the Pseudomonas chlororaphis strains DSM50083T and DSM50135. D. Pinho, S. Besson, C. D. Brondino, E. Pereira, B. De Castro e I. Moura J. Inorg. Biochem. 2004, 98, 276-286. 18 Cytotoxic Activity of Metal Complexes of Biogenic Polyamines: Polynuclear Platinum(II) Chelates. Luísa J. Teixeira, Marta Seabra, Elisa Reis, M. Teresa Girão da Cruz, M. Conceição Pedroso de Lima, Eulália Pereira, M. Adelaide Miranda e M. Paula M. Marques J. Med. Chem. 2004, 47, 2917-2925. 19 “Colorimetric detection of eukaryotic gene expression with DNA-derivatized gold nanoparticle”, P. Baptista, G. Doria, D. Henriques, E. Pereira, R. Franco, J. Biotechnol., 2005, Vol 119 (2), 111-117, DOI:10.1016/j.jbiotec.2005.02.019 20 “Mossbauer effect studies on the formation of iron oxide phases synthesized via microwave-hydrothermal route”, Bakare, P. P., Date, S. K., Khollam, Y. B., Deshpande, S. B., Potdar, H. S., Salunke-Gawali, S., Varret, F., and Pereira, E., Hyperfine Interact. 2006, 168, 1127-1132. 21 “Imaging gold nanoparticles for DNA sequence recognition in biomedical applications”, Eaton, P., Doria, G., Pereira, E., Baptista, P. V., and Franco, R., IEEE T. Nanobiosci. 2007, 6, 282-288. 22 “AFM and electron microscopy study of the unusual aggregation behavior of metallosurfactants based on iron(II) complexes with bipyridine ligands”, Garcia, P., Eaton, P., Geurts, H. P. M., Sousa, M., Gameiro, P., Feiters, M. C., Nolte, R. J. M., Pereira, E., and de Castro, B, Langmuir 2007, 23, 79517957. 23 “beta-Blockers and benzodiazepines location in SDS and bile salt micellar systems - An ESR study”, Reis, S., Moutinho, C. G., Pereira, E., de Castro, B., Gameiro, P., and Lima, J. L. F. C., J. Pharmaceut. Biomed. 2007, 45, 62-69. 24 “Synthesis, spectroscopic, electrochemical and structural characterization of Cu(II) complexes with asymmetric NN'OS coordination spheres”, Pereira, E., Gomes, L. R., Low, J. N., and de Castro, B., Polyhedron 2008, 27, 335343. 25 “Gold nanoparticles for the development of clinical diagnosis methods”, Baptista, P.; Pereira, E.; Eaton, P.; Doria, G.; Miranda, A.; Gomes, I.; Quaresma, P.; Franco, R. Anal. Bioanal. Chem. 2008, 391, 943-950. 26 “Probing Surface Properties of Cytochrome c at Au Bionanoconjugates”, Gomes, I.; Santos, N. C.; Oliveira, L. M. A.; Quintas, A.; Eaton, P.; Pereira, E.; Franco, R. J. Phys. Chem. C 2008, 112, 16340-16347. 27 “Atomic force microscopy study of the antibacterial effects of chitosans on Escherichia coli and Staphylococcus aureus”, Eaton, P.; Fernandes, J.C.; Pereira E., Pintado, M.E.; Malcata, F. X. Ultramicroscopy 2008, 108, 11281134 28 “Green photocatalytic synthesis of stable Au and Ag nanoparticles”, Quaresma, P.; Soares, L.; Contar, L.; Carvalho, P.A.; Franco, R.; Pereira, E. Green Chem. 2009, 11, 1889-1893 29 “Novel 3-hydroxy-4-pyridinonato oxidovanadium(IV) complexes to investigate structure/activity relationships”, Rangel, M.; Amorim M.J.; Nunes, A., Leite, A., Pereira, E.; de Castro, B.; Sousa, C.; Yoshikawa, Y.; Sakurai, H. J. Inorg. Biochem. 2009, 103, 496-502 30 “Superparamagnetic γ-Fe2O3@SiO2 nanoparticles: a novel support for the immobilization of [VO(acac)2]” Clara Pereira, André M. Pereira, Pedro Quaresma, Pedro B. Tavares, Eulália Pereira, João P. Araújo and Cristina Freire Dalton Trans., 2010, 39, 2842 – 2854; doi: 10.1039/b920853d 31 “Solution and biological behaviour of enrofloxacin metalloantibiotics: A route to counteract bacterial resistance?” Raúl Saraiva, Sandra Lopes, Mariana Ferreira, Florbela Novais, Eulália Pereira, Maria J. Feio and Paula Gameiro J. Inorg. Biochem., 2010, 104, 843 – 850; doi: 10.1016/j.jinorgbio.2010.03.017 32 “One-pot synthesis of triangular gold nanoplates allowing broad and fine tuning of edge length” Adelaide Miranda, Eliana Malheiro, Elzbieta Skiba, Pedro Quaresma, Patrícia A. Carvalho, Peter Eaton, Baltazar de Castro, John A. Shelnutt and Eulália Pereira Nanoscale 2010, 2, 2209-2216; doi: 10.1039/C0NR00337A 33 “New insights into the use of magnetic force microscopy to discriminate between magnetic and nonmagnetic nanoparticles” Cristina S. Neves, Pedro Quaresma, Pedro V. Baptista, Patrícia A. Carvalho, João Pedro Araújo, Eulália Pereira and Peter Eaton Nanotechnology 2010, 21, 305706 (9 p.); doi: 10.1088/0957-4484/21/30/305706 34 “Gold–silver-alloy nanoprobes for one-pot multiplex DNA detection” G. Doria, M. Larguinho, J. T. Dias, E. Pereira, R. Franco and P. V. Baptista Nanotechnology 2010, 21, 255101 doi: 10.1088/0957-4484/21/25/255101) 34 “Bionanoconjugates of tyrosinase and peptide-derivatised gold nanoparticles for biosensing of phenolic compounds” J. Cortez, E. Vorobieva, D. Gralheira, I. Osório, L. Soares, N. Vale, E. Pereira, P. Gomes, R. Franco J. Nanoparticle Res. 2011, 13, 1101–1113; doi 10.1007/s11051-010-0099-8 35 “Synthesis of gold nanocubes in aqueous solution with remarkable shapeselectivity” Adelaide Miranda, Eliana Malheiro, Peter Eaton, Patrícia A. Carvalho, Baltazar de Castro and Eulália Pereira J. Porph. Phthal. 2011, 15, 441-448; DOI No: 10.1142/S1088424611003367 36 “Gold nanoparticle-based fluorescence immunoassay for malaria antigen detection” Bassem S. S. Guirgis, Cláudia Sá e Cunha, Inês Gomes, Miguel Cavadas, Isabel Silva, Gonçalo Dória, Gregory L. Blatch, Pedro V. Baptista, Eulália Pereira, Hassan M. E. Azzazy, Maria M. Mota, Miguel Prudêncio, Ricardo Franco Anal. Bioanal. Chem. 2012, 402, 1019-27; DOI: 10.1007/s00216-011-5489-y 37 “Effect of surface coating on the biodistribution profile of gold nanoparticles in the rat.” Tiago Morais, Maria Elisa Soares, José Alberto Duarte, Leonor Soares, Sílvia Maia, Paula Gomes, Eulália Pereira, Sónia Fraga, Helena Carmo, Maria de Lourdes Bastos Eur. J. Pharm. Biopharm. 2012, 80, 18593; DOI: 10.1016/j.ejpb.2011.09.005 38 "Synthesis, characterization and antibacterial studies of a copper(II) levofloxacin ternary complex" Isabel Sousa, Vasco Claro, João Lino Pereira, Ana Luísa Amaral, Luís Cunha-Silva, Baltazar de Castro, Maria J. Feio, Eulália Pereira, Paula Gameiro J. Inorg. Biochem. 2012, 110, 64–71 39 "Controlled adsorption of cytochrome c to nanostructured gold surfaces." Inês Gomes, Maria J. Feio, Nuno C. Santo, Peter Eaton, Ana Paula Serro, Benilde Saramago, Eulália Pereira, Ricardo Franco J. Nanopart. Res. 2012, 12, 1321; DOI: 10.1007/s11051-012-1321-7 40 "Influence of the surface coating on the cytotoxicity and uptake of gold nanoparticles in human HEPG2 cells." Sónia Fraga, Helena Faria, Maria Elisa Soares, José Alberto Duarte, Leonor Soares, Eulália Pereira, Cristiana Costa-Pereira, João Paulo Teixeira, Félix Carvalho, Maria de Lourdes Bastos, Helena Carmo J. App. Toxicology 2013, 33(10), 1111-1119; DOI: 10.1002/jat.2865 41 "Europium-polyoxometalates encapsulated into silica nanoparticles: characterization and photoluminescence studies" Cristina S. Neves, Carlos M. Granadeiro, Luís Cunha-Silva, Duarte Ananias, Sandra Gago, Gabriel Feio, Patricia A. Carvalho, Peter Eaton, Salete S. Balula, Eulália Pereira Eur. J. Inorg. Chem. 2013, 2877-2886; DOI: 10.1002/ejic.201201482 42 "Synthesis, characterization and antibacterial studies of a copper(II) lomefloxacin ternary complex" Patrícia Fernandes, Isabel Sousa, Luís Cunha-Silva, Mariana Ferreira, Baltazar de Castro, Eulália F. Pereira, Maria J. Feio and Paula Gameiro J. Inorg. Biochem. 2014, 131, 21-29; DOI: dx.doi.org/10.1016/j.jinorgbio.2013.10.013 43 "Use of Gold Nanoparticles as Additives in Protein Crystallization" Diana Ribeiro, Alina Kulakova, Pedro Quaresma, Eulália Pereira, Cecília Bonifácio, Maria João Romão, Ricardo Franco, and Ana Luísa Carvalho Cryst. Growth Des. 2014 DOI: dx.doi.org/10.1021/cg4014398 44 "Star-shaped magnetite@gold nanoparticles for protein magnetic separation and SERS detection." Pedro Quaresma, Inês Osório, Gonçalo Dória, Patrícia A. Carvalho, Andre M Pereira, Judith Langer, Joao P Araujo, Isobel Pastoriza-Santos, Luis M. Liz-Marzán, Ricardo Franco, Pedro V Baptista and Eulália Pereira RSC Adv. 2013, Accepted Manuscript; DOI: 10.1039/C3RA46762G Book's Chapters: "Nanoparticles in Molecular Diagnostics" Baptista, P.V.; Doria, G.; Quaresma, P.; Cavadas, M.; Neves, C. S.; Gomes, I.; Eaton, P.; Pereira, E.; Franco, R. Nanoparticles in Molecular Diagnostics. In Nanoparticles in Translational Science and Medicine; Villaverde, A., Ed. Elsevier: London, 2011; Vol. 104, pp. 427-488 "Interactions of gold nanoparticles with proteins" Franco, R. and Pereira, E. in Encyclopedia of Metalloproteins; Kretsinger, Robert H.; Uversky, Vladimir N.; Permyakov, Eugene A., Eds. Springer: London, 2013 PATENTS: “DENDRITIC METAL NANOSTRUCTURES” US 7,374,599, B1, May 20, 2008, J. A. Shelnutt, C. Medforth, Y. Song, E. Pereira. “DENDRITIC METAL NANOSTRUCTURES” US 7,785,391, B1, Aug 31, 2010, J. A. Shelnutt, Y. Song, E. Pereira, C. J. Medforth ORGANIZATION OF SCIENTIFIC MEETINGS IV Conferência de Química Inorgânica da Sociedade Portuguesa de Química, Peniche, Portugal, 1999.