Curriculum Vitae - in der Universitätsmedizin Greifswald

Curriculum Vitae
Name:
Date of birth:
Born in:
Nationality:
Marital status:
Titus Kühne
21.09.1970
Hamburg
German
Married, one child
University studies
Electronics
1990 – 1992
1992
Medicine
1992 - 1994
1994
1994 - 1995
1995
1995 - 1998
1998
1999
Technical University of Berlin
“Vordiplom” (completion of the first part of the diploma)
Christian-Albrecht Universität zu Kiel
Physikum, Christian-Albrecht Universität zu Kiel
Université René-Descartes, Faculté de Médecine Necker-EnfantsMalades, Paris
1st Staatsexamen (state diploma), Université René-Descartes,
Faculté de Médecine Necker-Enfants-Malades, Paris
Humboldt Universität zu Berlin, Universitätsklinikum Charité,
Campus Virchow
2nd Staatsexamen (state diploma), Humboldt Universität zu Berlin,
Universitätsklinikum Charité, Campus Virchow
3rd Staatsexamen (state diploma), Humboldt Universität zu Berlin,
Universitätsklinikum Charité, Campus Virchow
Working experience abroad
1998 - 1998
Hôpital et Faculté de Médecine la Pitié-Salpêtrière, Université
Pierre & Marie Curie, Paris
1998 - 1998
Royal Brompton Hospital, National Heart & Lung Institute,
Imperial College, London
1998 - 1998
University of California, San Francisco
1998 - 1999
Faculté de Médecine Broussais, Université Pierre & Marie Curie,
Paris
Foreign Medical State Diploma
1997
1998
1999
1995
US Diploma
United States Medical Licensing Examination 1
Educational Commission for Foreign Medical Graduates 1
United States Medical Licensing Examination 2
French Diploma
DCEM 1 (equivalent to the German 1st state diploma)
Clinical qualifications
Fellowships / specialist training
1999 - 2001
University of California, San Francisco. Two-year fellowship
under the direction of Prof. Teitel, paediatric cardiology and Prof.
Higgins, radiology.
2001 - 2002
Universitätsklinikum Hamburg Eppendorf. One-year fellowship in
paediatric cardiology under the direction of Prof. Weil.
2002 - 2003
Deutsches Herzzentrum Berlin. One-year fellowship in congenital
heart diseases under the direction of Prof. Lange.
2003 - 2004
Humboldt Universität Berlin, Charité. One-year fellowship in
general paediatrics under the direction of Profs. Gaedicke and
Querfeld.
2004 - 2005
Deutsches Herzzentrum Berlin. One-year fellowship under the
direction of Prof. Berger in the paediatric cardiovascular intensive
care unit.
2005 – 2006
University Essen. Six-month fellowship under the direction of
Prof. Voit in the neonatal intensive care unit.
since Jan. 2006
Deutsches Herzzentrum Berlin, specialist training under the
direction of Prof. Berger in the cardiac catheterization laboratory.
Facharzt (specialist qualification)
11 Jan. 2006
Completion of the residency program in Paediatrics
Director
since 2004
Director of the MRI laboratory for congenital heart diseases
at the Deutsches Herzzentrum Berlin
Scientific qualifications
Doctoral theseis
01 Sep.1999
Habilitation
15 Mai 2006
Grants
University science
1999 - 2001
2000
2001
2002
2003
2002 - 2004
2003 - 2004
2003 – 2006
2005 – 2007
2006
2006
2007 – 2008
Oct. 2006
Feb. 2007
Charité, Universitätsmedizin Berlin. Topic: „In vitro und in vivo
evaluation of MRI flow analysis in patients with congenital heart
disease“
Charité, Universitätsmedizin Berlin. Topic: „Interventional
cardiovascular MRI“
Deutsche Forschungsgemeinschaft, stipend (approx. 100.000 €)
Senator Grant, University of California,
San Francisco (10,000 €)
Institutional grant, Stanford University (5,000 €)
Institutional grant, Universität Hamburg (approx. 45,000 €)
Otto-Werner Stiftung, Hamburg (approx. 5,000€)
Deutsche Forschungsgemeinschaft, stipend (approx.150,000 €)
Institutional grant, Charité, Universitätsmedizin Berlin
(app. 12,000 €)
German Federal Ministry for Science and Education (BMBF),
Competence Network for Congenital Heart Disease (approx. 7 bill.
€, 250,000 € of which for the „MRI“ project)
Deutsche Forschungsgemeinschaft, stipend (approx.160,000 €)
Institutional grant, Charité, Universitätsmedizin Berlin
(16.000 €)
German Federal Ministry for Science and Education (BMBF) and
Helmholtz society, approx. 120,000 € for the development of MRI
derived 3D-cast models of the heart
Gesellschaft zur Förderung Deutscher Kinderhezzentren,
application filed for 400,000 € for MRI hardware components,
decision pending
German Federal Ministry for Science and Education (BMBF),
Competence Network for Congenital Heart Disease (approx.
390,000 € for the „MRI“ project)
positiv votum for a 3 year “Heisenberg” stipend, Deutsche
Forschungsgemeinschaft
positiv votum for a 5 year grant „medical imaging“ of the German
Federal Ministry for Science and Education (BMBF)
Industry-sponsored science
2002 - 2006
Philips Medical Systems, NL, cooperation agreement
2002 - 2004
CR Bard/Angiomed, USA/GER, approx. 40,000 € and material
assets for the development of MRI compatible stents
2004
Biomedical Products, GER, material assets for the development of
biocompatible surfaces in valved stents
2006
Novartis, CH, approx. 60,000 € and material assets for the
development of antiproliferative therapy in endovascular implants.
Academic education
Teaching of students
2001 – 2006
More than 230 hours of teaching (lectures and training courses) of
undergraduates and graduates students at the Charité,
Universitätsmedizin Berlin.
Specialized training of physicians
2003 – 2006
More than 120 hours of teaching physicians in topics of
cardiovascular MRI (certified as „continuing medical education“)
at the „Cardiac MRI academy Berlin“
Others
Foreign languages:
Music / Dance:
English, French, Spanish
Piano / Tango Argentine
Publications
First and last authorship
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Krueger JJ, Ewert P,Yilmaz S, Gelernter D, Peters B, Pietzner K,
Bornstedt A, Schnackenburg B, Abdul-Khaliq A, Fleck E., Nagel E,
Berger F, Kuehne T. MRI guided balloon angioplasty of coarctation
of the aorta: A pilot study. Circulation 2006;113:1093-110
Kuehne T, Yilmaz S, Schulze-Neick I, Wellnhofer W, Ewert P,
Lange P. MRI guided catheterization for assessment of pulmonary
vascular resistance: in-vivo validation and clinical application in
patients with pulmonary hypertension. Heart. 2005 8;91(8):1064-9
Kuehne T, Gleason K, Saeed M, et al. Effects of combined
pulmonary stenosis and insufficiency on biventricular function in the
developing heart of growing swine. J Appl Physiol. 2005
10;99(4):1422-7
Kuehne T, Yilmaz S, Steendijk P, Moore P, Groenink M, Saaed M,
Weber O, Higgins CB, Ewert P, Fleck E, Nagel E, Schulze-Neick I,
Lange P. Magnetic resonance imaging analysis of right ventricular
pressure-volume loops: in vivo validation and clinical application in
patients with pulmonary hypertension. Circulation. 2004 Oct
5;110(14):2010-6.
Kuehne T, Weiss S, Brinkert F, Weil J, Yilmaz S, Schmitt B, Ewert
P, Lange P, Gutberlet M. Catheter visualization with resonant
markers at MR imaging-guided deployment of endovascular stents
in swine. Radiology. 2004 Dec;233(3):774-80.
Kuehne T, Yilmaz S, Meinus C, Moore P, Saeed M, Weber O,
Higgins CB, Blank T, Elsaesser E, Schnackenburg B, Ewert P,
Lange PE, Nagel E. Magnetic resonance imaging-guided
transcatheter implantation of a prosthetic valve in aortic valve
position: Feasibility study in swine. J Am Coll Cardiol. 2004 Dec
7;44(11):2247-9.
Kuehne T, Saeed M, Higgins CB, Gleason K, Krombach GA,
Weber OM, Martin AJ, Turner D, Teitel D, Moore P. Endovascular
stents in pulmonary valve and artery in swine: feasibility study of
MR imaging-guided deployment and postinterventional
assessment. Radiology. 2003 Feb;226(2):475-81.
Kuehne T, Saeed M, Gleason K, Turner D, Teitel D, Higgins CB,
Moore P. Effects of pulmonary insufficiency on biventricular
function in the developing heart of growing swine. Circulation.
2003 Oct 21;108(16):2007-13.
Kuehne T, Fahrig R, Butts K. Pair of resonant fiducial markers for
localization of endovascular catheters at all catheter orientations.
J Magn Reson Imaging. 2003 May;17(5):620-4.
Kuehne T, Saeed M, Moore P, Gleason K, Reddy G, Teitel D,
Higgins CB. Influence of blood-pool contrast media on MR imaging
and flow measurements in the presence of pulmonary arterial
stents in swine. Radiology. 2002 May;223(2):439-45.
Impact 11.3
Impact 2.3
Impact 2.2
Impact 11.3
Impact 6.5
Impact 6.7
Impact 6.5
Impact 11.3
Impact 1.8
Impact 6.5
11
Kuehne T, Saeed M, Reddy G, Akbari H, Gleason K, Turner D,
Teitel D, Moore P, Higgins CB. Sequential magnetic resonance
monitoring of pulmonary flow with endovascular stents placed
across the pulmonary valve in growing Swine. Circulation. 2001
Nov 6;104(19):2363-8.
Total
Impact 11.3
77.7
Co-authorship
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K. Norozi, J. Bahlmann, B. Raab, V. Alpers, JO. Arnhold, T.
Kuehne, K. Klimes, M. Zoege, S. Geyer, A. Wessel, R. Buchhorn.
A prospective, randomized, double-blind, placebo controlled trial of
beta blockade in patients underwent surgical corrections for
tetralogy of Fallot. Card in the Young. 2006, in press
S. Mottl-Link, T. Böttger, JJ. Krueger, U. Rietdorf, B.
Schnackenburger, P. Ewert, F. Berger, HP. Meinzer, A. Juraszek,
T. Kuehne, I. Wolf. Cast of complex congenital heart malformation
in a living patient. Circulation. 2005 Dec 13;112(24):e356
Wellnhofer E, Ewert P, Hug J, Hui W, Kretschmar O, Chavengsuk
D, Kuehne T, et al. Evaluation of new software for angiographic
determination of right ventricular volumes. Int J Cardiovasc Imag.
2005
Weiss S, Kuehne T, Brinkert B, et al. In-vivo safe catheter
visualization and slice tracking using an optically detunable
resonant marker. MRM 2004
Gutberlet M, Boeckel T, Hosten N, Kuehne T et al. Arterial switch
procedure for D-transposition of the great arteries: quantitative
midterm evaluation of
hemodynamic changes with cine MR
imaging and phase-shift velocity mapping-initial experience.
Radiology 2000
Weiss S, Schaeffter T, Brinkert F, Kuehne T, Bücker A. Approach
for Safe Visualization and Localization of Catheters during MRguided Intravascular Procedures. Zeitschrift für medizinische
Physik 2002
Hosten N, Gutberlet M, Kuehne T et al. Kardiale MR Flußmessung:
Experimentelle Validierung und Ergebnisse bei Patienten mit
operierten Herzfehlern, Röfo 1998
Krombach B, Higgins CH, Günther J, Kuehne T, Maythem S.
Anwendung von Kontrastmitteln für Kardiovaskuläre
Magnetresonanztomographische Interventionen. Röfo 2002
Weiss F, Habermann CR, Lilje C, Sasse K, Kuehne T, Weil J,
Adam G. MRI in postoperative assessment of univentricular heart
disease: correlation with echocardiography and angiography. Röfo
2002
Total
Impact 0.6
Impact 11.3
Impact 0.2
Impact 1.5
Impact 6.5
Impact 0.1
Impact 1.7
Impact 1.7
Impact 1.7
25.3
Book chapters and review articles
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Kuehne T. New Therapeutic Approaches: MRI Guided
Interventions of the Heart. Heart and Metabolism 2006, in press
Kuehne T “Interventional MRI in Congenital Heart Disease” in
Higgings CB, de Roose A: MRI and CT of the Cardiovascular
System. Lippincott Williams and Wilkins, Philadelphia 2005
Reddy G, Higgins CB, Kuehne T „Congenital Heart Disease“ in
Higgins CB: Cardiac MR Imaging. Lippincott Williams and Wilkins,
Philadelphia 2001
Manuscripts under preparation / submitted
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Mottl-Link S, , Böttge T, Kuehne T, Krueger JJ, Rietdorf U,
Schnackenburg B, Berger F, Meinzer HP, Juraszek A, , Wolf I,
Individual rapid prototyping models replicating complex congenital
heart disease in the living.
Kuehne T, Lehmkuhl H, Pietzner K, Blank T, Krüger JJ, Berger F.
Oral everolimus inhibits neointimal proliferation in
prosthetic pulmonary valved stents in pigs.
Kuehne T, Blank T, Schnackenburg B, Berger F. Development of a
MRI compatible stent for noninvasive quantification of in-stent
stenosis.
Kuehne T, Krueger JJ, Schulze-Neick I, Pietzner K,
Schnackenburg B, Abdul-Khaliq A, Berger F,. Beat-to-beat analysis
of biventricular pressure-volume loops using real-time MRI.
Klimes K, Fröhlich C, Kelte-Klöpping A, Beerbaum P, Gutberlet M,
Kuehne T. Cardiac function analysis with MRI: assessment of
measurement accuracy in a multicenter study.
Fröhlich C, Klimes K, Kelte-Klöpping A, Beerbaum P, Gutberlet M,
Kuehne T. Normal values of cardiovascular function in a healthy
pediatric and adult pupulation.
Kuehne T, Koehler U, Nagel E, Fleck E, Berger F. Anatomic
mapping of the atrial-ventricular node at high resolution MRI.