COMUNICAÇÃO TÉCNICA Nº 173774 Production of O/W

COMUNICAÇÃO TÉCNICA
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Nº 173774
Production of O/W emulsion employing microfluidic systems
Bianca Oliveira Agio
H. Cobas-Gomez
L.K.Rincon-Ardila
J.G. Silva
Adriano Marim de Oliveira
Mario Ricardo Gongora-Rubio
Resumo aspresentado no 14, BRAZILIAN MRS MEETING,
Rio de Janeiro, 2015.
A série “Comunicação Técnica” compreende trabalhos elaborados por técnicos do IPT, apresentados em
eventos, publicados em revistas especializadas ou quando seu conteúdo apresentar relevância pública.
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Instituto de Pesquisas Tecnológicas do Estado de São Paulo
S/A - IPT
Av. Prof. Almeida Prado, 532 | Cidade Universitária ou
Caixa Postal 0141 | CEP 01064-970
São Paulo | SP | Brasil | CEP 05508-901
Tel 11 3767 4374/4000 | Fax 11 3767-4099
www.ipt.br
Production of O/W emulsion employing microfluidic
systems.
B.O. Agio1, H. Cobas-Gomez2, L. K. Rincon-Ardila1, J. G. Silva1, A. M. Oliveira1 &
M.R. Gongora-Rubio1
1
Instituto de Pesquisas Tecnológicas do Estado de São Paulo (IPT), Núcleo de
Bionanomanufatura, Av. Prof. Almeida Prado, 532, 05508-901, São Paulo, Brazil
2
Escola Politécnica da USP, Cidade Universitária
Abstract:
The nanoencapsulation process of solids or liquids with polymeric coating is one of the most
used techniques in the pharmaceutical area. Among the various nanocapsule fabrication
process, the method of emulsion-diffusion occurs by diffusion of solvent from an initial
solution formed by polymer, solvent and non-solvent. The aim of this work is to test various
microfluidic mixers, with various lengths, with a standard formulation for obtaining adequate
emulsions for the recommended nanoencapsulation process, in the size range required. The
standart formulation uses two solutions: an organic phase composed of PCL, Pluronic-127,
GTCC and ethyl acetate, and aqueous phase composed of Tween 20, ethyl acetate and
distilled water. The mixing of the phases is obtained by a microfluidic device that performs
the process along a series of microchannels to produce the emulsion. This technique displays
high efficiency in a low residence time. Size measurements were made, by the dynamic light
scattering method of the samples obtained using various microfluidic devices for mixing. The
retrieved diameters were between 374,1 nm and 1777 nm with polydispersity index between
0,117 and 0,541.
Acknowledgments
FINEP – Agência Brasileira de Inovação, CNPq
References
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