Hippocampal rhythmopathies in temporal lobe epilepsy

Invitation to Seminar Talk
Hippocampal rhythmopathies
in temporal lobe epilepsy
Liset Menéndez de la Prida
(Department of Functional and Systems Neurobiology, Instituto Cajal - CSIC)
Host: Jozsef Csicsvari
Natural rhythms of the hippocampus, including theta (4-12 Hz), gamma (40-120 Hz) and high-frequency
oscillations (150-200 Hz), play different roles in orchestrating neuronal firing during different cognitive
demands. In temporal lobe epilepsy (TLE), the most frequent form of refractory epilepsy in human, the
hippocampus produces distorted oscillations that presumably reflect the underlying alterations of circuits
and neurons. Are there common principles in the cellular processes responsible for theta, gamma and
ripple oscillations in the normal and the epileptic hippocampus? In this talk I will discuss on our recent data
aimed to identify the rules governing hippocampal rhythmopathies in TLE and their relationship with the
physiological hippocampal function. We will examine different in vitro and in vivo data from normal and
epileptic rats, as well as human data, obtained with a combination of techniques including multi-site
recordings and single-cell electrophysiology.
Thursday, March 13th 2014, 11:00am
Seminar Room, Lab Building East, Ground Floor
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